KR20050114929A - Composition for treating and preventing constipation - Google Patents

Abstract

The present invention is a composition for the treatment and prevention of constipation, which contains Sukji Hwang, Cheonggung and Angelica mixed extract and Cha-Phi powder as main ingredients, and may contain herbal medicines, food ingredients, vitamins, minerals and other food additives as auxiliary ingredients. The composition of the invention can be used in medicines and nutraceuticals.

Description

Composition for treating and preventing constipation

The present invention relates to a composition for the treatment and prevention of constipation, containing Sukjiwang, Cheongung and Angelica mixed extract and Cha bark powder as main components having the therapeutic and prophylactic activity of constipation.

Recently, more people are complaining of constipation due to various factors such as lack of dietary fiber due to increased consumption of meat and fast food due to westernization of diet and stress due to industrialization.

Constipation is defined as constipation when medically referred to as less than three times a week or less than 30 g per day. In normal conditions, after 24 hours of food intake is excreted in feces, but people with constipation, even if you see the stool once a few days or every day, the amount of the intestinal dwelling of the ingested food is longer.

There are many causes of constipation, such as decreased bowel movements due to manure in the morning, lack of dietary fiber due to westernization of diet, low basic physical strength and abs due to lack of exercise, diet and drug addiction due to overdose. have.

Constipation, which is said to be the source of all kinds of illnesses, has no appetite and always has a bloated abdomen, and the toxins of unexcreted stools are absorbed into the blood through the intestine to promote skin aging, headaches, acne, and skin rashes. This appears, if constipation is severe causes of hemorrhoids, such as breakage of the teeth at the time of defecation and escape of dentifrice, and toxins in the shift to colon cancer. In addition, if constipation persists, cholesterol or fat, which should be released into the body, may remain in the body, leading to atherosclerosis or cholelithiasis, and further, high blood pressure and cardiac hypertrophy, which may worsen heart disease. In addition, constipation is an important disease that requires active prevention and treatment because it causes various serious secondary diseases such as stroke, immune deficiency, vision disorder, mental illness (depression).

To this end, various medicines and functional foods have been sold for the treatment and improvement of constipation, but most of the medicines are used during pregnancy with side effects such as abdominal pain and diarrhea by using irritating agents containing anthraquinone derivatives such as senna and rhubarb. However, there is a problem in continuous taking, and even in the case of functional foods are not scientifically proven to be effective enough to solve the fundamental problem of constipation improvement is the situation that the reliability of the product is falling.

Therefore, the present inventors have studied the composition for the treatment and prevention of constipation effectively and safely through the scientific effect on constipation using the herbal medicines Sujihwang, Cheonggung, Angelica and Cha-eung, which are traditionally used for a long time and have been verified for their safety. .

Sukjihwang that are steamed and then processing the rhizome of Rehmannia dried in the sun, the taste is sweet and slightly warm nature, the efficacy of the blood (Deut mingyo and information boseop, hyangyak Dictionary, Younglim four, pp908-909, 1998).

Cnidium officinale is a perennial herb, 30-60 cm high, tastes sour and warm. The components are known as cinidilide, ligustilide, neocinidilide, butylphthalide, sedanonic acid and the like. As a pharmacological effect, it was recognized that there is an inhibitory effect on the cerebrum in a small amount, and it shows a slight effect on the heart, and directly expands microvascular vessels, and when a large amount is used, the blood pressure drops and a small amount increases the blood pressure. In addition, a small amount of the firmament, but the number to shrink the uterus, rather than in bulk is thereby expand the uterus (New mingyo and information boseop, hyangyak Dictionary, Younglim four, pp418-419, 1998).

Angelica is the root of the Angelica gigas and Angelica, sweet and sour taste, warm, blood-repellent action, cold effect on the limbs and lower back, menstrual disorders, menstrual pain, hysteria, menopausal disorders, headache, anemia, etc. It strengthens the body's metabolism and endocrine function, and improves blood circulation, so it is good for people with weak constitution, poor pregnancy, and weak heart (Shin Folk and Jung Bo-seop, Yakdae Dictionary , Younglimsa) , pp 407-408, 1998).

Chasons are seeds of plantain or cohort related plants. Chajeonjapi is put into its shell taste, nature has an effect on the heel against diuretic and arthritis (new mingyo and information boseop, hyangyak Dictionary, Younglim four, pp1005-1006, 1998).

Accordingly, the present inventors have completed the present invention by confirming that the composition consisting of Sukji Hwang, Cheongung and Angelica mixed extract and cha-chae blood and the like during the search for substances effective in treating and improving constipation are effective in constipation.

Accordingly, it is an object of the present invention to provide a composition for the treatment and prevention of constipation containing Sukji Hwang, Cheonggung and Angelica mixed extract and Cha bark powder as a main component.

In addition, the composition of the present invention can be useful in the treatment and prevention of constipation as a medicine or health functional food prepared by various formulations, such as pills, tablets, powders, granules, capsules for improving intestinal function and relieve constipation.

In order to achieve the above object, it provides a composition for the treatment and prevention of constipation containing Sukji Hwang, Cheonggung and Angelica mixed extract and chaff blood powder as a main component.

The constituent ratios of Sukji sulfur, Cheongung, Angelica, and chaff bark, which are the main components in the composition, contain 12-50% of Sukji sulfur, 7-30% of cheonggung, 10-40%, Chagongpi of 5-20%, based on dry weight. do.

In addition, as an auxiliary component of the composition, including cellulose, such as cha jeonja blood, Garcinia cambogia extract, kelp, black beans, perilla, chitosan, Angelica, propolis, pine needles, yeast, Seokchangpo, jujube, astronomical dong, baekbokyeong, vitamins, minerals or other Appropriate amount of the approved food additives, etc. may be included.

Sukjihwang of the present invention is effective in addictive constipation when taken with broth boiled pork, Angelica has the effect of releasing constipation, chaeun blood is largely expanded to excrete impurities attached to the barrier to remove old feces Excretize clean, so the amount of stools increases. It also acts on the intestinal wall, promoting peristalsis, reviving the movement rhythm of the large intestine, and maintaining the size of the sides suitable for excretion.

Hereinafter, the present invention will be described in detail.

In order to prepare the extract of Sukji sulfur, Cheonggung and Angelica, which are the main components of the present invention, first, after drying, grinding Sukjihwang, Cheonggung and Angelica, powdering them, mixing them according to their mixing ratios, and then about 3 to 3 weights of each dry weight. 20 times, preferably about 3 to 5 times the volume of water, lower alcohols such as ethanol, methanol and butanol or a mixed solvent having a mixing ratio of about 1: 0.1 to 1:10, preferably 20 Extraction method such as hot water extraction, cold extraction, reflux extraction or ultrasonic extraction for about 0.5 hours to 2 days, preferably 3 hours to 1 day at an extraction temperature of from 100 to 100 ° C., preferably 70 to 100 ° C., preferably Is extracted by hot water extraction 1 to 5 times, preferably 2 to 3 times in succession and filtered under reduced pressure, and the filtrate extract is 1 to 48 hours at minus 4 to 70 ℃, preferably minus 40 ℃ In the meantime, it is preferable to rapidly freeze for 10 to 20 hours, vacuum-dried for 35 hours or more under a pressure of 0.23 Torr or less, and then pulverize to prepare a mixture extract of Sukji Hwang, Cheonggung and Angelica of the present invention. In addition, it is possible to prepare the composition of the present invention by mixing the chaff powder.

Garcinia Cambosia Extract, 2 to 8 parts by weight, and L-Carnitine (L-Carnitine) 0.4 to 1.6 based on 100 parts by weight of the composition as an auxiliary ingredient in the composition of the present invention prepared by the above manufacturing process The parts by weight may be mixed.

The present invention provides a pharmaceutical composition effective for the treatment and prevention of constipation containing Sukji Hwang, Cheonggung and Angelica mixed extract obtained by the above production method and chaff blood powder as a main component.

A pharmaceutical composition effective for the treatment and prevention of constipation containing Sukjihwang, Cheongung and Angelica mixed extract of the present invention and chaff skin powder as a main component, 0.1 to 80% by weight, preferably 1.0 to 50% by weight of the main component relative to the total weight of the composition Contains%

Pharmaceutical dosage forms of the compositions of the present invention may be used in the form of their pharmaceutically acceptable salts, and may be used alone or in combination with other pharmaceutically active fractions, as well as in any suitable collection.

The composition containing Sukji sulfur, Cheongung and Angelica mixed extract of the present invention and the chaff powder as a main component may further include a suitable carrier, excipient or diluent commonly used in the manufacture of a pharmaceutical composition. Carriers, excipients and diluents that may be included in the composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, Methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.

The compositions according to the invention can be used in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral formulations, external preparations, suppositories or sterile injectable solutions, respectively, according to conventional methods. have. Specifically, it may be formulated using diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, surfactants, etc. that are commonly used when formulated. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and such solid preparations include at least one excipient such as starch, calcium carbonate, sucrose in the composition. ) Or lactose, gelatin and the like can be mixed. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Oral liquid preparations include suspensions, solvents, emulsions, and syrups.In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories. As the non-aqueous solvent and suspending agent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate and the like can be used. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.

The amount of the composition containing Sookjihwang, Cheonggung and Angelica mixed extract and chaff blood powder as a main component may vary depending on the age, sex and weight of the patient, but generally in an amount of 0.01 to 500 mg / kg, preferably 0.1 to 100 An amount of ˜200 mg / kg may be administered once to several times daily. In addition, the dosage of the composition may be increased or decreased depending on the route of administration, type and severity of disease, sex, weight, age, and the like. Therefore, the above dosage does not limit the scope of the present invention in any aspect.

The composition of the present invention can be administered to mammals such as rats, mice, livestock, humans, etc. by various routes. All modes of administration can be expected, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intrauterine dural or intracerebroventricular injection.

The composition itself containing Sukji Hwang, Cheonggung and Angelica mixed extract of the present invention and the chaff blood powder as the main component has almost no toxicity and side effects, and therefore can be used with confidence even for long-term administration.

The present invention provides a health functional food comprising a composition containing food extracts of Sukji, cheongung, and Angelica gigas, and Cha bark powder as main ingredients, and a food supplement acceptable additive.

The composition of the present invention can be used in a variety of food and beverages for the prevention and improvement of constipation. Foods to which the composition of the present invention can be added include various foods, for example, candy, chocolate, beverages, gums, teas, vitamin complexes, health functional foods, and the like, and powders, granules, tablets, capsules or beverages. Available in form.

At this time, the amount of the composition in the food or beverage, in the case of the health functional food composition of the present invention can generally be added to 0.01 to 50% by weight, preferably 0.1 to 20% by weight of the total functional food composition, In the case of 0.02 to 10 g, preferably 0.3 to 1 g, based on 100 ml.

The health functional beverage composition of the present invention is not particularly limited in the liquid component except for containing the composition as an essential ingredient in the indicated ratio, and may contain various flavors or natural carbohydrates, etc. as additional ingredients, as in general beverages. . Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; Polysaccharides such as dextrin, cyclodextrin and the like; Conventional sugars such as and sugar alcohols such as xylitol, sorbitol, erythritol. The proportion of such natural carbohydrates is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention.

Other flavors may be advantageously used natural flavors (tautin, stevia extracts (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.). The composition of the present invention is a variety of nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese, chocolate), pectic acid and salts thereof, alginic acid and salts thereof , Organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, etc. Other compositions of the present invention may include natural fruit juices and fruit juice beverages and vegetable beverages. The components may be used independently or in combination The ratio of these additives is not critical but is zero per 100 parts by weight of the composition of the present invention. It is generally selected from the range of about 20 parts by weight.

The present invention is described in more detail based on the following examples and experimental examples, but the present invention is not limited to the examples or experimental examples.

Example 1 Preparation of Extract of Main Ingredient

Sukjihwang (10 kg), Cheongung (6 kg), Angelica (1 kg) were mixed, 10 times weight of water was poured and heated to extract hot water at 100 ° C for 3 hours, and then rapidly frozen at -40 ° C for 15 hours. And, under a pressure of 0.23 Torr or less and vacuum dried for more than 35 hours and then pulverized to prepare the main components of the present invention Sukjihwang, Cheonggung and Angelica mixed extract (12.4 kg) (see Fig. 1).

Example 2. Preparation of Composition

The composition was prepared by mixing the chaff blood powder (4 kg) evenly with the main component (12.4 kg) prepared in Example 1.

Example 3. Preparation of Pills

A suitable amount of rice flour and soy flour in the composition prepared in Example 2 was mixed and tableted according to a conventional pill manufacturing method to prepare a pill.

Example 4. Preparation of Product

The composition prepared in Example 2 was packaged in a single dose (4.0 g) unit in an aluminum pack to prepare a product for the treatment and prevention of constipation.

Experimental Example 1. Clinical Experiment

In order to determine the effect on the constipation of the composition prepared in Example 2 was carried out the following experiment.

Forty-five test takers and office workers with constipation symptoms were studied. Five placebo-administered groups were used as controls. A questionnaire was conducted regarding the change in constipation symptoms while taking 4.0 g of the composition of the present invention on an empty stomach for breakfast, lunch and dinner for 30 days.

According to a questionnaire survey on constipation symptoms after taking the composition of the present invention, only 20% of the respondents answered that they had stool once a day before taking the composition, whereas 60% of the total respondents showed the stool once a day after taking the composition. In addition, the time required for stool reduction also decreased from an average of 15 minutes to 7 minutes before taking. Fecal pain during defecation Most respondents reported little or no pain less than once a month, and 60% of respondents felt that they had remnants 2-3 times a month, whereas most respondents after taking Responsiveness disappeared. In addition, the frequency of difficulty during defecation was also reduced to less than once or 2-3 times a month to confirm the significant constipation improvement effect of the composition of the present invention (see Figure 2a to 2e).

The composition containing Sukji Hwang, Cheonghung and Angelica mixed extract of the present invention and Cha-Phi powder as main components and containing Cha-P-P powder, Garcinia cambogia extract and L-carnitine as auxiliary components can be administered in the following formulations, It is only illustrative of the present invention, and the content of the present invention is not limited thereto.

Formulation Example 1 Preparation of Injection

100 mg of the composition of Example 2

Sodium Metabisulfite 3.0 mg

Methylparaben 0.8 mg

Propylparaben 0.1 mg

Appropriate sterile distilled water for injection

The above ingredients are mixed and prepared in a conventional manner to have a final volume of 2 ml, and then filled into 2 ml ampoules and sterilized to prepare an injection.

Formulation Example 2 Preparation of Tablet

200 mg of the composition of Example 2

Lactose 100 mg

Starch 100 mg

Magnesium stearate proper amount

A tablet is prepared by mixing and tableting the above components according to a conventional tablet manufacturing method.

Formulation Example 3 Preparation of Capsule

100 mg of the composition of Example 2

Lactose 50 mg

Starch 50 mg

Talc 2 mg

Magnesium stearate appropriate amount

According to a conventional capsule preparation method, the above ingredients were mixed and filled into gelatin capsules to prepare capsules.

Formulation Example 4 Preparation of Liquid

1000 mg of the composition of Example 2

20 g of sugar

20 g of isomerized sugar

Lemon flavor

Purified water was added to adjust the total volume to 1000 ml. According to the conventional method for preparing a liquid, the above components were mixed, and then filled into a brown bottle and sterilized to prepare a liquid.

Formulation Example 5 Preparation of Healthy Food

1000 mg of the composition of Example 2

Vitamin mixture proper amount

Vitamin A Acetate 1.0 mg

Vitamin B ₁ 0.13 mg

Vitamin B ₂ 0.15 mg

Vitamin B ₆ 0.5 mg

0.2 μg of vitamin B ₁₂

Vitamin C 10 mg

10 μg biotin

Nicotinic Acid 1.7 mg

Folate 50 ㎍

Calcium Pantothenate 0.5mg

Mineral mixture

Ferrous Sulfate 1.75 mg

Zinc Oxide 0.82 mg

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Dibasic calcium phosphate 55 mg

Potassium Citrate 90 mg

Calcium Carbonate 100 mg

Magnesium chloride 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixtures is mixed with a component suitable for a health food in a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional health food manufacturing method. The granules may be prepared and used for preparing a health food composition according to a conventional method.

Formulation Example 6 Preparation of Healthy Drink

1000 mg of the composition of Example 2

Citric acid 1000 mg

100 g oligosaccharides

Plum concentrate 2 g

1 g of taurine

Add 900 ml of purified water

After mixing the above components in accordance with the conventional healthy beverage production method, and stirred and heated at 85 ℃ for about 1 hour, the resulting solution is filtered and obtained in a sterilized 2 L container, sealed sterilized and stored in the refrigerator and then Used to prepare the healthy beverage composition of the invention.

As described above, the composition containing the medicinal extract of Sukji Hwang, Cheonggung and Angelica of the present invention and the chaff blood powder as the main components have an excellent effect on the improvement of constipation symptoms, weight loss, etc., as a composition for the treatment and prevention of constipation Can be used in nutraceuticals.

1 is a view showing a manufacturing process of the lyophilized composition of the present invention,

Figure 2a is a diagram showing the constipation period of the clinical trial subjects,

Figure 2b is a diagram showing the number of bowel movements of the clinical trial subjects before, after taking the composition of the present invention,

Figure 2c is a diagram showing the time required for bowel movement before and after the composition of the present invention,

Figure 2d is a diagram showing the frequency of pain during defecation before and after taking the composition of the present invention,

Figure 2e is a diagram showing the residual feeling of bowel movement before and after taking the composition of the present invention.

Claims (6)

Pharmaceutical composition for the treatment and prevention of constipation containing Sukjihwang, Cheonggung and Angelica mixed extract and Cha bark powder as essential ingredients. According to claim 1, wherein the composition of the main components of the ripening sulfur, cheonggung, donkey and tea bark contains 12 to 50%, sootung 7 to 30%, Angelica 10 to 40% and chaff bark 5 to 20% based on the dry weight Pharmaceutical composition, characterized in that. The method according to claim 1, wherein 2 to 8 parts by weight of Garcinia Cambosia Extract (Garcinia Cambosia Extract) and 0.4 to 1.6 parts by weight of L-Carnitine are used as auxiliary ingredients in the mixture of Sookji Hwang, Cheongung and Angelica gigas and Cha bark powder. Pharmaceutical composition, characterized in that. The method according to claim 1, wherein the composition is mixed with 12 to 50% by weight of Sukji sulfur, 7 to 30% by weight and Angelica 10 to 40% by weight, followed by hot water extraction, and then obtained by rapid freezing and vacuum drying Pharmaceutical composition, characterized in that the mixture is prepared by mixing 5 to 20% by weight of chaff powder. A health functional food comprising a composition containing a medicinal herb, cheonggung and tangunggi extract of claim 1 and chaff bark powder as main ingredients, and a food supplement acceptable additive, which are effective for the prevention and improvement of constipation. The health functional food of Claim 5 which is a health drink.