Summary of the invention
For above-mentioned situation, technical problem solved by the invention is to provide a kind of granatum Chinese yam dispersible tablet and preparation method of invigorating the spleen to arrest diarrhea, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of granatum Chinese yam dispersible tablet, comprise following parts by weight ingredient: red granatum 100-300 part, Chinese yam 100-300 part, honeysuckle 80-120 part, vitamin C 1.75-3.75 part, vitamin A 0.01-0.02 part, zinc gluconate 0.15-0.35 part, microcrystalline cellulose 40-60 part, haw thorn extract 0.12-0.32 part, American ginseng extract 0.12-0.32 part, sweet mellow wine 100-170 part, chitosan oligosaccharide 1.2-3.2 part, Thick many candies 1.2-3.2 part, Sucralose 10-15 part, superfine silica gel powder 10-50 part, carboxymethyl cellulose 3-5 part, sodium carboxymethyl starch 55-80 part, dolomol 4-6 part, Purified Water q. s, 75% concentration ethanol is appropriate.
As preferably, described a kind of granatum Chinese yam dispersible tablet, comprise following parts by weight ingredient: red granatum 200 parts, Chinese yam 200 parts, honeysuckle 100 parts, vitamin C 2.75 parts, vitamin A 0.015 part, zinc gluconate 0.25 part, microcrystalline cellulose 50 parts, haw thorn extract 0.22 part, American ginseng extract 0.22 part, 135 parts, sweet mellow wine, chitosan oligosaccharide 2.2 parts, Thick many candies 2.2 parts, Sucralose 12.5 parts, superfine silica gel powder 30 parts, carboxymethyl cellulose 4 parts, sodium carboxymethyl starch 67.5 parts, dolomol 5 parts, Purified Water q. s, 75% concentration ethanol is appropriate.
A preparation method for granatum Chinese yam dispersible tablet, comprises the following steps:
(1) get after fresh Chinese yam is cleaned and soak 15-20min in the vitamin C aqueous solution of 0.1%, Chinese yam after immersion is put in freeze drier and carries out freeze drying, first open refrigerator to freeze, be chilled to raw material Chinese yam temperature within the scope of-20 to-30 DEG C, and maintain 8-10h drying, then vacuum is opened, and be heated to 95-100 DEG C, continue dry 1-3h, the solid matter that above-mentioned freeze drying obtains is pulverized, obtained Chinese yam freeze-dried powder, for subsequent use;
(2) get the red granatum of raw material, honeysuckle is cleaned, the 4-5 times amount purified water adding above-mentioned raw materials gross weight decocts 2-2.5h within the scope of 90-100 DEG C, filter, the purified water that the dregs of a decoction after filtration add 2-4 times amount is decocted 1-1.5h within the scope of 90-100 DEG C, filter, filter residue is discharged, merge twice filtrate, and carry out being concentrated into the gamma amylase adding 1-2 ‰ when proportion is 1-1.5, at 35-45 DEG C of scope inside holding 5-10h, filter after finally boiling 25-35min, obtain mixed extract, for subsequent use;
(3) be uniformly mixed by gained mixed extract in step (1) gained Chinese yam freeze-dried powder and step (2), mixer speed is 50-75r/min, and the time is 10-15min, obtains mixture I, for subsequent use;
(4) adding ethanol to gained mixture I in step (3) makes determining alcohol reach 75%, filter after leaving standstill 8-16h, impurity is discharged, at temperature 40-60 DEG C after recovery ethanol, under vacuum 0.58-0.68MPa condition, Vacuum Concentration reaches 50-70% to dry substance, carry out vacuum drying again, within the scope of baking temperature 40-60 DEG C, obtain dry extract, for subsequent use;
(5) add after step (4) gained dry extract being pulverized vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, haw thorn extract, American ginseng extract, sweet mellow wine, chitosan oligosaccharide, Thick many candies, Sucralose, superfine silica gel powder mixing machine mixing make particle, rotating speed is 10-15r/min, time is 6-8min, by mixing after particle 50-60 DEG C of scope inner drying to water content between 1-3%, for subsequent use;
(6) add sodium carboxymethyl starch, dolomol mixing to gained particle in step (5), tabletted, obtains granatum Chinese yam dispersible tablet.
Get in described step (1) after fresh Chinese yam is cleaned and soak 20min in the vitamin C aqueous solution of 0.1%, Chinese yam after immersion is put in freeze drier and carries out freeze drying, first open refrigerator to freeze, be chilled to raw material Chinese yam temperature dry for maintaining 8h when-26 DEG C, then vacuum is opened, and continue dry 2.5h when being heated to 95 DEG C, the solid matter that above-mentioned freeze drying obtains is pulverized, obtained Chinese yam freeze-dried powder.
Get the red granatum of raw material in described step (2), honeysuckle is cleaned, the 6 times amount purified water adding above-mentioned raw materials gross weight decoct 2h under 90 DEG C of conditions, filter, the purified water that the dregs of a decoction after filtration add 3 times amount is decocted 1.5h under 90 DEG C of conditions, filters, filter residue is discharged, merge twice filtrate, and carry out being concentrated into the gamma amylase adding 2 ‰ when proportion is 1, under 45 DEG C of conditions, be incubated 6h, filter after finally boiling 35min, obtain mixed extract.
In sum, beneficial effect of the present invention:
The present invention has invigorating the spleen to arrest diarrhea, is applicable to baby diarrhea.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described gained technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on gained embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A kind of granatum Chinese yam dispersible tablet, comprises following parts by weight ingredient: red granatum 100 parts, Chinese yam 100 parts, honeysuckle 80 parts, vitamin C 1.75 parts, vitamin A 0.01 part, zinc gluconate 0.15-0.35 part, microcrystalline cellulose 40 parts, haw thorn extract 0.12 part, American ginseng extract 0.12 part, 100 parts, sweet mellow wine, chitosan oligosaccharide 1.2 parts, Thick many candies 1.2 parts, Sucralose 10 parts, superfine silica gel powder 10 parts, carboxymethyl cellulose 3 parts, sodium carboxymethyl starch 55 parts, dolomol 4 parts, Purified Water q. s, 75% concentration ethanol are appropriate.
A preparation method for granatum Chinese yam dispersible tablet, comprises the following steps:
(1) get after fresh Chinese yam is cleaned and soak 15-20min in the vitamin C aqueous solution of 0.1%, Chinese yam after immersion is put in freeze drier and carries out freeze drying, first open refrigerator to freeze, be chilled to raw material Chinese yam temperature within the scope of-20 to-30 DEG C, and maintain 8-10h drying, then vacuum is opened, and be heated to 95-100 DEG C, continue dry 1-3h, the solid matter that above-mentioned freeze drying obtains is pulverized, obtained Chinese yam freeze-dried powder, for subsequent use;
(2) get the red granatum of raw material, honeysuckle is cleaned, the 4-5 times amount purified water adding above-mentioned raw materials gross weight decocts 2-2.5h within the scope of 90-100 DEG C, filter, the purified water that the dregs of a decoction after filtration add 2-4 times amount is decocted 1-1.5h within the scope of 90-100 DEG C, filter, filter residue is discharged, merge twice filtrate, and carry out being concentrated into the gamma amylase adding 1-2 ‰ when proportion is 1-1.5, at 35-45 DEG C of scope inside holding 5-10h, filter after finally boiling 25-35min, obtain mixed extract, for subsequent use;
(3) be uniformly mixed by gained mixed extract in step (1) gained Chinese yam freeze-dried powder and step (2), mixer speed is 50-75r/min, and the time is 10-15min, obtains mixture I, for subsequent use;
(4) adding ethanol to gained mixture I in step (3) makes determining alcohol reach 75%, filter after leaving standstill 8-16h, impurity is discharged, at temperature 40-60 DEG C after recovery ethanol, under vacuum 0.58-0.68MPa condition, Vacuum Concentration reaches 50-70% to dry substance, carry out vacuum drying again, within the scope of baking temperature 40-60 DEG C, obtain dry extract, for subsequent use;
(5) add after step (4) gained dry extract being pulverized vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, haw thorn extract, American ginseng extract, sweet mellow wine, chitosan oligosaccharide, Thick many candies, Sucralose, superfine silica gel powder mixing machine mixing make particle, rotating speed is 10-15r/min, time is 6-8min, by mixing after particle 50-60 DEG C of scope inner drying to water content between 1-3%, for subsequent use;
(6) add sodium carboxymethyl starch, dolomol mixing to gained particle in step (5), tabletted, obtains granatum Chinese yam dispersible tablet.
Embodiment 2
A kind of granatum Chinese yam dispersible tablet, comprises following parts by weight ingredient: red granatum 200 parts, Chinese yam 200 parts, honeysuckle 100 parts, vitamin C 2.75 parts, vitamin A 0.015 part, zinc gluconate 0.25 part, microcrystalline cellulose 50 parts, haw thorn extract 0.22 part, American ginseng extract 0.22 part, 135 parts, sweet mellow wine, chitosan oligosaccharide 2.2 parts, Thick many candies 2.2 parts, Sucralose 12.5 parts, superfine silica gel powder 30 parts, carboxymethyl cellulose 4 parts, sodium carboxymethyl starch 67.5 parts, dolomol 5 parts, Purified Water q. s, 75% concentration ethanol are appropriate.
A preparation method for granatum Chinese yam dispersible tablet, comprises the following steps:
(1) get after fresh Chinese yam is cleaned and soak 15-20min in the vitamin C aqueous solution of 0.1%, Chinese yam after immersion is put in freeze drier and carries out freeze drying, first open refrigerator to freeze, be chilled to raw material Chinese yam temperature within the scope of-20 to-30 DEG C, and maintain 8-10h drying, then vacuum is opened, and be heated to 95-100 DEG C, continue dry 1-3h, the solid matter that above-mentioned freeze drying obtains is pulverized, obtained Chinese yam freeze-dried powder, for subsequent use;
(2) get the red granatum of raw material, honeysuckle is cleaned, the 4-5 times amount purified water adding above-mentioned raw materials gross weight decocts 2-2.5h within the scope of 90-100 DEG C, filter, the purified water that the dregs of a decoction after filtration add 2-4 times amount is decocted 1-1.5h within the scope of 90-100 DEG C, filter, filter residue is discharged, merge twice filtrate, and carry out being concentrated into the gamma amylase adding 1-2 ‰ when proportion is 1-1.5, at 35-45 DEG C of scope inside holding 5-10h, filter after finally boiling 25-35min, obtain mixed extract, for subsequent use;
(3) be uniformly mixed by gained mixed extract in step (1) gained Chinese yam freeze-dried powder and step (2), mixer speed is 50-75r/min, and the time is 10-15min, obtains mixture I, for subsequent use;
(4) adding ethanol to gained mixture I in step (3) makes determining alcohol reach 75%, filter after leaving standstill 8-16h, impurity is discharged, at temperature 40-60 DEG C after recovery ethanol, under vacuum 0.58-0.68MPa condition, Vacuum Concentration reaches 50-70% to dry substance, carry out vacuum drying again, within the scope of baking temperature 40-60 DEG C, obtain dry extract, for subsequent use;
(5) add after step (4) gained dry extract being pulverized vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, haw thorn extract, American ginseng extract, sweet mellow wine, chitosan oligosaccharide, Thick many candies, Sucralose, superfine silica gel powder mixing machine mixing make particle, rotating speed is 10-15r/min, time is 6-8min, by mixing after particle 50-60 DEG C of scope inner drying to water content between 1-3%, for subsequent use;
(6) add sodium carboxymethyl starch, dolomol mixing to gained particle in step (5), tabletted, obtains granatum Chinese yam dispersible tablet.
Embodiment 3
A kind of granatum Chinese yam dispersible tablet, comprises following parts by weight ingredient: red granatum 300 parts, Chinese yam 300 parts, honeysuckle 120 parts, vitamin C 3.75 parts, vitamin A 0.02 part, zinc gluconate 0.35 part, microcrystalline cellulose 60 parts, haw thorn extract 0.32 part, American ginseng extract 0.32 part, 170 parts, sweet mellow wine, chitosan oligosaccharide 3.2 parts, Thick many candies 3.2 parts, Sucralose 15 parts, superfine silica gel powder 50 parts, carboxymethyl cellulose 5 parts, sodium carboxymethyl starch 80 parts, dolomol 6 parts, Purified Water q. s, 75% concentration ethanol are appropriate.
A preparation method for granatum Chinese yam dispersible tablet, comprises the following steps:
(1) get after fresh Chinese yam is cleaned and soak 15-20min in the vitamin C aqueous solution of 0.1%, Chinese yam after immersion is put in freeze drier and carries out freeze drying, first open refrigerator to freeze, be chilled to raw material Chinese yam temperature within the scope of-20 to-30 DEG C, and maintain 8-10h drying, then vacuum is opened, and be heated to 95-100 DEG C, continue dry 1-3h, the solid matter that above-mentioned freeze drying obtains is pulverized, obtained Chinese yam freeze-dried powder, for subsequent use;
(2) get the red granatum of raw material, honeysuckle is cleaned, the 4-5 times amount purified water adding above-mentioned raw materials gross weight decocts 2-2.5h within the scope of 90-100 DEG C, filter, the purified water that the dregs of a decoction after filtration add 2-4 times amount is decocted 1-1.5h within the scope of 90-100 DEG C, filter, filter residue is discharged, merge twice filtrate, and carry out being concentrated into the gamma amylase adding 1-2 ‰ when proportion is 1-1.5, at 35-45 DEG C of scope inside holding 5-10h, filter after finally boiling 25-35min, obtain mixed extract, for subsequent use;
(3) be uniformly mixed by gained mixed extract in step (1) gained Chinese yam freeze-dried powder and step (2), mixer speed is 50-75r/min, and the time is 10-15min, obtains mixture I, for subsequent use;
(4) adding ethanol to gained mixture I in step (3) makes determining alcohol reach 75%, filter after leaving standstill 8-16h, impurity is discharged, at temperature 40-60 DEG C after recovery ethanol, under vacuum 0.58-0.68MPa condition, Vacuum Concentration reaches 50-70% to dry substance, carry out vacuum drying again, within the scope of baking temperature 40-60 DEG C, obtain dry extract, for subsequent use;
(5) add after step (4) gained dry extract being pulverized vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, haw thorn extract, American ginseng extract, sweet mellow wine, chitosan oligosaccharide, Thick many candies, Sucralose, superfine silica gel powder mixing machine mixing make particle, rotating speed is 10-15r/min, time is 6-8min, by mixing after particle 50-60 DEG C of scope inner drying to water content between 1-3%, for subsequent use;
(6) add sodium carboxymethyl starch, dolomol mixing to gained particle in step (5), tabletted, obtains granatum Chinese yam dispersible tablet.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or essential characteristic, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and in each embodiment, gained technical scheme also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.