CN103725714A - 一种中国被毛孢菌粉生产方法 - Google Patents
一种中国被毛孢菌粉生产方法 Download PDFInfo
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- CN103725714A CN103725714A CN201210389147.5A CN201210389147A CN103725714A CN 103725714 A CN103725714 A CN 103725714A CN 201210389147 A CN201210389147 A CN 201210389147A CN 103725714 A CN103725714 A CN 103725714A
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- 239000000843 powder Substances 0.000 title claims abstract description 78
- 241001248610 Ophiocordyceps sinensis Species 0.000 title claims abstract description 32
- 230000001580 bacterial effect Effects 0.000 title claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 15
- 238000000855 fermentation Methods 0.000 claims description 88
- 230000004151 fermentation Effects 0.000 claims description 88
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 80
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 40
- 239000008103 glucose Substances 0.000 claims description 40
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 40
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 40
- 239000001888 Peptone Substances 0.000 claims description 39
- 108010080698 Peptones Proteins 0.000 claims description 39
- 235000019319 peptone Nutrition 0.000 claims description 39
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 210000000582 semen Anatomy 0.000 claims description 28
- 235000010749 Vicia faba Nutrition 0.000 claims description 27
- 240000006677 Vicia faba Species 0.000 claims description 27
- 235000002098 Vicia faba var. major Nutrition 0.000 claims description 27
- 229940041514 candida albicans extract Drugs 0.000 claims description 27
- 239000012138 yeast extract Substances 0.000 claims description 27
- 230000002538 fungal effect Effects 0.000 claims description 19
- 239000013589 supplement Substances 0.000 claims description 18
- 235000015099 wheat brans Nutrition 0.000 claims description 13
- 229920001817 Agar Polymers 0.000 claims description 12
- 239000008272 agar Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 5
- 238000000034 method Methods 0.000 abstract description 8
- 235000015097 nutrients Nutrition 0.000 abstract description 5
- 238000009655 industrial fermentation Methods 0.000 abstract description 2
- 238000009776 industrial production Methods 0.000 abstract description 2
- 239000001963 growth medium Substances 0.000 abstract 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- 241000190633 Cordyceps Species 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 241000255789 Bombyx mori Species 0.000 description 3
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 241000330899 Hepialus Species 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 229960005305 adenosine Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- LBPACUJFGRCWDF-UHFFFAOYSA-L Cl[Mg]Cl.[Na] Chemical compound Cl[Mg]Cl.[Na] LBPACUJFGRCWDF-UHFFFAOYSA-L 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 239000011790 ferrous sulphate Substances 0.000 description 2
- 235000003891 ferrous sulphate Nutrition 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- CNFDGXZLMLFIJV-UHFFFAOYSA-L manganese(II) chloride tetrahydrate Chemical compound O.O.O.O.[Cl-].[Cl-].[Mn+2] CNFDGXZLMLFIJV-UHFFFAOYSA-L 0.000 description 2
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000006052 feed supplement Substances 0.000 description 1
- 238000012262 fermentative production Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000027272 reproductive process Effects 0.000 description 1
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CN201210389147.5A CN103725714B (zh) | 2012-10-16 | 2012-10-16 | 一种中国被毛孢菌粉生产方法 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105670942A (zh) * | 2016-03-15 | 2016-06-15 | 江苏神华药业有限公司 | 一种快速深层液态发酵生产中国被毛孢菌粉的方法 |
CN106190866A (zh) * | 2016-08-11 | 2016-12-07 | 青海珠峰冬虫夏草工程技术研究有限公司 | 一种冬虫夏草发酵废液的再利用方法 |
CN106434388A (zh) * | 2016-11-30 | 2017-02-22 | 青海珠峰冬虫夏草工程技术研究有限公司 | 一种能辅助降血糖的中国被毛孢菌粉的生产方法 |
CN106754401A (zh) * | 2016-11-22 | 2017-05-31 | 青海珠峰冬虫夏草工程技术研究有限公司 | 一种中国被毛孢菌的生产方法 |
CN109355204A (zh) * | 2018-11-28 | 2019-02-19 | 马兰 | 一种发酵生产冬虫夏草菌丝体粉的方法 |
CN110342991A (zh) * | 2019-05-10 | 2019-10-18 | 宁夏西麒麟生物科技有限公司 | 来源于发酵冬虫夏草的有机肥 |
CN112617015A (zh) * | 2020-12-15 | 2021-04-09 | 青海珠峰冬虫夏草工程技术研究有限公司 | 含中国被毛孢培养物的饲料添加剂组合物及其制备方法 |
CN112795493A (zh) * | 2021-04-02 | 2021-05-14 | 青海珠峰冬虫夏草原料有限公司 | 一种提高发酵冬虫夏草菌丝体产量的方法 |
CN116333963A (zh) * | 2021-12-23 | 2023-06-27 | 江苏神华药业有限公司 | 一种中国被毛孢的快速深层液态发酵培养方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102220249A (zh) * | 2011-06-13 | 2011-10-19 | 杭州柯氏生物科技有限公司 | 一种中国被毛孢的生产方法 |
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2012
- 2012-10-16 CN CN201210389147.5A patent/CN103725714B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102220249A (zh) * | 2011-06-13 | 2011-10-19 | 杭州柯氏生物科技有限公司 | 一种中国被毛孢的生产方法 |
Non-Patent Citations (1)
Title |
---|
赵怡红 等: "不同豆类氮源对北冬虫夏草生长影响的研究", 《青海师范大学学报(自然科学版)》, no. 2, 31 December 2009 (2009-12-31), pages 52 - 55 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105670942A (zh) * | 2016-03-15 | 2016-06-15 | 江苏神华药业有限公司 | 一种快速深层液态发酵生产中国被毛孢菌粉的方法 |
CN106190866A (zh) * | 2016-08-11 | 2016-12-07 | 青海珠峰冬虫夏草工程技术研究有限公司 | 一种冬虫夏草发酵废液的再利用方法 |
CN106190866B (zh) * | 2016-08-11 | 2019-09-20 | 青海珠峰冬虫夏草工程技术研究有限公司 | 一种冬虫夏草发酵废液的再利用方法 |
CN106754401A (zh) * | 2016-11-22 | 2017-05-31 | 青海珠峰冬虫夏草工程技术研究有限公司 | 一种中国被毛孢菌的生产方法 |
CN106434388A (zh) * | 2016-11-30 | 2017-02-22 | 青海珠峰冬虫夏草工程技术研究有限公司 | 一种能辅助降血糖的中国被毛孢菌粉的生产方法 |
CN109355204A (zh) * | 2018-11-28 | 2019-02-19 | 马兰 | 一种发酵生产冬虫夏草菌丝体粉的方法 |
CN110342991A (zh) * | 2019-05-10 | 2019-10-18 | 宁夏西麒麟生物科技有限公司 | 来源于发酵冬虫夏草的有机肥 |
CN112617015A (zh) * | 2020-12-15 | 2021-04-09 | 青海珠峰冬虫夏草工程技术研究有限公司 | 含中国被毛孢培养物的饲料添加剂组合物及其制备方法 |
CN112795493A (zh) * | 2021-04-02 | 2021-05-14 | 青海珠峰冬虫夏草原料有限公司 | 一种提高发酵冬虫夏草菌丝体产量的方法 |
CN112795493B (zh) * | 2021-04-02 | 2023-07-07 | 青海珠峰冬虫夏草原料有限公司 | 一种提高发酵冬虫夏草菌丝体产量的方法 |
CN116333963A (zh) * | 2021-12-23 | 2023-06-27 | 江苏神华药业有限公司 | 一种中国被毛孢的快速深层液态发酵培养方法 |
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Address after: 810012 Qinghai province Xining Biotechnology Industrial Park by two Road No. 16 Applicant after: Qinghai Zhufeng Aweto Pharmaceutical Industry Co., Ltd. Address before: 810012 Qinghai Xining economic and Technological Development Zone, East New Road No. 19 Applicant before: Qinghai Zhufeng Aweto Pharmaceutical Industry Co., Ltd. |
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Address after: 810012 Qinghai province Xining Biotechnology Industrial Park by two Road No. 16 Patentee after: Qinghai Mount Everest caterpillar fungus Pharmaceutical Group Co., Ltd. Address before: 810012 Qinghai province Xining Biotechnology Industrial Park by two Road No. 16 Patentee before: Qinghai Zhufeng Aweto Pharmaceutical Industry Co., Ltd. |
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Effective date of registration: 20170726 Address after: 810000 Xining biological science and Technology Industrial Park, No. two, No. 16, Qinghai Patentee after: Qinghai Mount Everest Cordyceps Engineering Technology Co., Ltd. Address before: 810012 Qinghai province Xining Biotechnology Industrial Park by two Road No. 16 Patentee before: Qinghai Mount Everest caterpillar fungus Pharmaceutical Group Co., Ltd. |
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Effective date of registration: 20180112 Address after: 850000 Lhasa City, Tibet autonomous region, Lhasa City, Liu Wu new area, Hai Liang two period 1 Building 1 unit 1002 room Patentee after: Tibet Zhao Kang health management Co., Ltd. Address before: 810000 Xining biological science and Technology Industrial Park, No. two, No. 16, Qinghai Patentee before: Qinghai Mount Everest Cordyceps Engineering Technology Co., Ltd. |
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Effective date of registration: 20180322 Address after: 850000 Lhasa City, Tibet, Liu Wu New District, Liu Wu building, 11 floor Patentee after: Tibet KANGYI trillion Cordyceps biotechnology limited company products Address before: 850000 Lhasa City, Tibet autonomous region, Lhasa City, Liu Wu new area, Hai Liang two period 1 Building 1 unit 1002 room Patentee before: Tibet Zhao Kang health management Co., Ltd. |
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