CN103721222B - A kind of medicine for the treatment of endometriosis and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of medicine for the treatment of endometriosis and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as Caulis Sargentodoxae, Radix Rhapontici, Fructus Crataegi, Carapax Trionycis, Herba Artemisiae Anomalae, Hirudo, Radix Xylosmae japonici, Radix Achyranthis Bidentatae, Herba Kalimeridis, medicine of the present invention has warming middle-JIAO by cold, nourishing YIN and supplementing blood, effect of promoting blood circulation and stopping pain, be used for the treatment of endometriosis instant effect, good effect, do not recur.

Description

A kind of medicine for the treatment of endometriosis and preparation method thereof

Technical field

The present invention relates to a kind of medicine being used for the treatment of endometriosis and preparation method thereof, belong to the field of Chinese medicines.

Technical background

When the endometrial tissue with growth function appears at other positions of health beyond cavity of uterus lining mucosa, be called endometriosis.Endometrium growth under gonadal hormone impact of heterotopic partial, develops or disappears.Ectopic Endometrium can grow at the position away from uterus, as groin, umbilicus, lung, diaphragm etc., but most pathological changes appears at the peritoneum face of pelvic cavity internal genitalia and its adjacent organs, often be called endometriosis of pelvis clinically, if endometrium occurs and grows when myometrium, be called adenomyosis.The former is called external type endometriosis by the past, and the latter is called inherent type endometriosis, because both cause of disease, epidemiologic feature and symptom are all different, therefore should distinguish and treats.Endometriosis is a kind of common and perplexing gynaecopathia.This disease is generally detected in the women of childbearing age, in the majority with 30 ~ 40 years old women, without morbidity before initial stage, post menopausal endometriotic tissues can absorb gradually in atrophy, gestation or can ovarian function be suppressed with gonadal hormone, this sick development of temporary transient prevention, Fructus Psoraleae Endometriosis is a kind of sex hormone-dependent disease.Its sickness rate constantly increases, and in sexual maturity women, the incidence rate of Endometriosis is 1% ~ 15%.At present, western medicine endometriosis poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating endometriosis in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment endometriosis, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating endometriosis.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Caulis Sargentodoxae selected by medicine of the present invention, Radix Rhapontici, Fructus Crataegi, Carapax Trionycis, Herba Artemisiae Anomalae, Hirudo, Radix Xylosmae japonici, Radix Achyranthis Bidentatae, Herba Kalimeridis, Semen Coicis, Rhizoma Zingiberis, Rhizoma Chuanxiong, Rhizoma Corydalis, Endothelium Corneum Gigeriae Galli, Fructus Foeniculi, Herba Lycopodii, Rhizoma Curculiginis, Rhizoma Corydalis, Spina Gleditsiae, Cortex Lycii, Herba Patriniae, Fructus Toosendan, Colla Corii Asini, Squama Manis, Oletum Trogopterori, Radix Pseudostellariae, Flos abelmoschi manihot, Pollen Typhae, Aspongopus, Testis et penis callorhini, Semen Litchi, Fructus Evodiae, Fructus Hordei Germinatus, Semen Sinapis Albae, arnebia medicinal carries out combining, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating endometriosis.Caulis Sargentodoxae is wherein selected to be that flat, enter liver, large intestine two warp, relieve internal heat eliminating carbuncle, promoting blood circulation to remove obstruction in the collateral, the function of wind dispelling insecticide, controls acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition because its nature and flavor are bitter, worm pain, injury from falling down.Select Radix Rhapontici to be because its nature and flavor hardship is salty-cold, enter stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of stimulating milk secretion, control the swollen pain of breast, galactostasis, toxic-heat and blood stasis, arthralgia.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.Carapax Trionycis is selected to be because its nature and flavor are salty, flat, enter liver, spleen channel, have replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, the function of hard masses softening and resolving, control consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly ， mass in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, little Jing Epilepsy.Select Herba Artemisiae Anomalae to be because its nature and flavor are bitter, temperature, enter the heart, spleen channel, have removing blood stasis to stimulate the menstrual flow, the function of healing up sore and subduing swelling, controls amenorrhea and mass in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.Select Hirudo to be because the salty hardship of its nature and flavor, flat, poisonous, enter liver, urinary bladder channel, have removing blood stasis, removing blood stasis, the function of stimulating the menstrual flow, control blood-retention ， mass in the abdomen, gather, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Radix Xylosmae japonici is selected to be because its nature and flavor are put down, bitter, subcutaneous ulcer of harnessing the Yellow River, edema, pulmonary tuberculosis.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid, flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury, ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Herba Kalimeridis is selected to be that enter positive bright blood system, have removing heat from blood, heat clearing away, dampness removing, the function of removing toxic substances, controls haematemesis, epistaxis, dysentery, wound hemorrhage, malaria, jaundice, edema, stranguria with turbid discharge, pharyngalgia, sore throat, hemorrhoid, carbuncle, erysipelas, venom because its nature and flavor are pungent, cool.Semen Coicis is selected to be that cool, enter spleen, lung, kidney channel, have spleen invigorating, tonifying the lung, heat clearing away, the function of dampness removing, controls and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea because its property slightly sweet flavor.Select Rhizoma Zingiberis to be that heat, enters spleen, stomach, lung meridian because its nature and flavor are pungent, have warming middle-JIAO by cold, the function that recuperating depleted YANG is promoted blood circulation, controls trusted subordinate's cold type of pain, vomits and diarrhoea, cold extremities faint pulse, and cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, and yang deficiency is told, be defeated in battle, hematochezia.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Rhizoma Corydalis is selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Select Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, control stagnant, the function of strengthening the spleen and stomach, control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Select Fructus Foeniculi to be that temperature, returns liver,kidney,spleen, stomach warp, have dispersing cold for relieving pain, the function of regulating qi-flowing for harmonizing stomach because its nature and flavor are pungent, control colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, distension and fullness in the abdomen, lack of appetite and vomiting, hydrocele of testis.Select Herba Lycopodii to be because its nature and flavor toil, temperature, enters liver, stomach, kidney three warp, has expelling wind and cold, and dehumidifying detumescence, the function of relaxing muscles and tendons to promote blood circulation, controls anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, edema, traumatic injury.Select Rhizoma Curculiginis to be because its nature and flavor are pungent, temperature, poisonous, enter kidney, Liver Channel, have the kidney warming sun, the function of strengthening bone and muscle, controls sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula.Rhizoma Corydalis is selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Select Spina Gleditsiae to be that temperature, searches wind, draw out pus by applying a plaster to the affected part because its nature and flavor are pungent, detumescence, the function of evacuation of pus, controls carbuncle, sore, leprosy, tinea skin ulcer, placenta retention.Optionally Cortex Lycii is because its nature and flavor are sweet, cold, and enter lung, liver, kidney channel, have heat clearing away, the function of removing heat from blood, control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Herba Patriniae is selected to be that flat, enter liver, stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of evacuation of pus removing blood stasis with potent drugs, controls acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain, carbuncle scabies because its nature and flavor are bitter.Select Fructus Toosendan to be because its nature and flavor are bitter, cold, poisonous, enter liver, stomach, small intestine meridian, have wet down heat, clearing away liver-fire, pain relieving, the function of parasite killing, controls epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.Select Colla Corii Asini to be that flat, enter lung, liver, kidney channel, have nourishing YIN and supplementing blood, antiabortive function, controls blood deficiency, cough due to consumptive disease because its nature and flavor are sweet, haematemesis, epistaxis, to have blood in stool, menoxenia, metrorrhagia, vaginal bleeding during pregnancy.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of stimulating milk secretion of stimulating the menstrual flow, control carbuncle skin ulcer and swell, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external is stopped blooding.Select Oletum Trogopterori to be because its property bitter but sweet flavor, temperature, enters liver, spleen channel, and raw by the function having promoting the circulation of blood pain relieving, control all pains of trusted subordinate's vim and vigour, women's amenorrhea, postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite, stir-fry is stopped blooding, and control metrorrhagia, menorrhagia, leucorrhea with bloody discharge is without cease.Radix Pseudostellariae is selected to be that tepor, enters the heart, spleen, lung three warp, have the function of tonifying the lung, spleen invigorating, control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus order antiperspirant, metal fatigue because its nature and flavor sweetness and bitterness.Select Flos abelmoschi manihot to be because the sweet cunning of its nature and flavor, cold, have removing toxic substances, the function of detumescence, controls gonorrhea, leucorrhea with red and white discharge.Select Pollen Typhae to be because its nature and flavor are sweet arduous, cool, enter liver, heart channel, have cooling blood for hemostasis, the function of activating blood circulation and dissipating blood stasis, raw with controlling amenorrhea stomachache, postpartum stagnation is had a pain, and falls that to flutter blood vexed, furuncle toxic swelling, fries black emesis blood, epistaxis, metrorrhagia, rush down blood, hematuria, dysentery, leukorrhagia, external treatment congenital deformity of the tongue, aphtha, Ting discharging ear, hemorrhage in ear, uncontrolled urination is itched.Select Aspongopus to be because its nature and flavor are salty, temperature, enter liver, kidney channel, have regulating QI to relieve pain, the function of warming middle-JIAO tonifying YANG, control the chest and diaphragm stagnation of QI, gastralgia painful abdominal mass is vexed, spleen-kidney deficiency, and waist knee joint is miserable, sexual impotence.Select Testis et penis callorhini to be because its nature and flavor are salty, heat, enters liver, kidney channel, has warming the kidney tonifying YANG, and benefit essence mends the function of marrow, and control deficient impairment caused by overstrain, sexual impotence essence declines, waist knee flaccidity.Select Semen Litchi to be because its property sweet-puckery flavor, temperature, enter liver, kidney channel, have warming middle-JIAO, regulate the flow of vital energy, the function of pain relieving, controls gastric abscess, colicky, women's pricking caused by the stagnation of QI and blood.Select Fructus Evodiae to be because its nature and flavor are worked hard, temperature, poisonous, enter liver, stomach warp, have warming middle-JIAO, pain relieving, regulate the flow of vital energy, the function of dampness, stopping vomiting is against acid regurgitation, and headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.Fructus Hordei Germinatus is selected to be that tepor, enters spleen, stomach warp, have and help digestion because its nature and flavor are sweet, and in, the function of the therapeutic method to keep the adverse QI flowing downwards, control food stagnation and do not disappear, distension and fullness in the abdomen, inappetence, vomiting is had loose bowels, and mammary swelling does not disappear.Select Semen Sinapis Albae to be that temperature, enters lung, stomach warp, have promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, the function of removing obstruction in the collateral to relieve pain, control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain because its nature and flavor are pungent, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Radix Arnebiae (Radix Lithospermi) is selected to be because its nature and flavor earnestly, are trembled with fear, entered percardium, Liver Channel, have removing heat from blood, invigorate blood circulation, the function of heat-clearing and toxic substances removing, control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Caulis Sargentodoxae 5-15 gram of Radix Rhapontici 10-20 Keshan short, bristly hair or beard 10-20 gram

Carapax Trionycis 10-20 gram of Herba Artemisiae Anomalae 5-15 gram of Hirudo 10-20 gram

The Radix Xylosmae japonici 10-20 gram of blue 5-15 gram of Radix Achyranthis Bidentatae 10-20 Rana nigromaculata

Semen Coicis 5-15 gram of Rhizoma Zingiberis 5-15 gram of Rhizoma Chuanxiong 5-15 gram

Rhizoma Corydalis 10-20 gram of Endothelium Corneum Gigeriae Galli 5-15 gram of Fructus Foeniculi 5-15 gram

Herba Lycopodii 5-15 gram of Rhizoma Curculiginis 3-9 gram of Rhizoma Corydalis 3-9 gram

Spina Gleditsiae 3-9 gram of Cortex Lycii 25-35 gram of Herba Patriniae 5-15 gram

Fructus Toosendan 10-20 gram of Colla Corii Asini 15-25 gram of Squama Manis 20-30 gram

Oletum Trogopterori 5-15 gram of Radix Pseudostellariae 5-15 gram of Flos abelmoschi manihot 3-9 gram

Pollen Typhae 8-15 gram of Aspongopus 10-20 gram of Testis et penis callorhini 5-15 gram

Semen Litchi 5-15 gram of Fructus Evodiae 3-9 gram of Fructus Hordei Germinatus 3-9 gram

Semen Sinapis Albae 5-15 gram of Radix Arnebiae (Radix Lithospermi) 10-20 gram

Preferable amount is

Caulis Sargentodoxae 10 grams of Radix Rhapontici 15 Keshan short, bristly hair or beards 15 grams

Carapax Trionycis 15 grams of Herba Artemisiae Anomalaes 10 grams of Hirudos 15 grams

Blue 10 grams of Radix Xylosmae japonici 15 grams of Radix Achyranthis Bidentatae 15 Rana nigromaculata

Semen Coicis 10 grams of Rhizoma Zingiberiss 10 grams of Rhizoma Chuanxiongs 10 grams

Rhizoma Corydalis 15 grams of Endothelium Corneum Gigeriae Galli 10 grams of Fructus Foeniculi 10 grams

Herba Lycopodii 10 grams of Rhizoma Curculiginises 6 grams of Rhizoma Corydalis 6 grams

Spina Gleditsiae 6 grams of Cortex Lycii 30 grams of Herba Patriniaes 10 grams

Fructus Toosendan 15 grams of Colla Corii Asini 20 grams of Squama Maniss 25 grams

Oletum Trogopterori 10 grams of Radix Pseudostellariaes 10 grams of Flos abelmoschi manihots 6 grams

Pollen Typhae 10 grams of Aspongopuss 15 grams of Testis et penis callorhinis 10 grams

6 grams, Semen Litchi 10 grams of Fructus Evodiaes 6 grams of Fructus Hordei Germinatus

Semen Sinapis Albae 10 grams of Radix Arnebiae (Radix Lithospermi)s 15 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Caulis Sargentodoxae: be soaked in water, cleans spare, runs through, and section, dries;

2, Radix Rhapontici: pick clean impurity, unhairing is cleaned, and runs through, and section, dries;

3, Fructus Crataegi: pick clean impurity, sieve enucleation;

4, Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;

5, Herba Artemisiae Anomalae: pick clean impurity, remove root, uses water edulcoration, slightly soaks, cutting, dry;

6, Hirudo: clean, vexed soft, cutting, dries;

7, Radix Xylosmae japonici: after autumn take root, cleans, and section, dries;

8, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

9, Herba Kalimeridis: summer, autumn gather, using fresh herb or dry;

10, Semen Coicis: get crude drug, removing residual cot, impurity;

11, Rhizoma Zingiberis: pick clean impurity, be soaked in water 3-6 hour, pulls out, cuts into slices or dice, dry after moistening;

12, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;

13, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

14, Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;

15, Fructus Foeniculi: get crude drug, removing impurity;

16, Herba Lycopodii: sieve dedust bits, pick clean impurity, be cut into segment;

17, Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, puts micro-stir-fry in pot and, to dry, take out, dry, every Rhizoma Curculiginis 100 jin, with yellow wine 10-20 jin;

18, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

19, Spina Gleditsiae: pick decontamination, is soaked in water, and runs through rear section, dries;

20, Cortex Lycii: pick decontamination and core, slightly wash, cutting, dry;

21, Herba Patriniae: get crude drug, removing impurity, with Water spray, slightly dries in the air, and cutting is dry;

22, Fructus Toosendan: pick decontamination, cleans, and dries, grating or cleave in two;

23, Colla Corii Asini: smash use to pieces;

24, Squama Manis: get the Squama Manis sheet picking clean, separately size, separately puts sand in pot and makes popular, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;

25, Oletum Trogopterori: pick clean impurity, smashes or sieves dedust bits;

26, Radix Pseudostellariae: extract fibrous root, dry;

27, Flos abelmoschi manihot: pick clean impurity, dry;

28, Pollen Typhae: rub broken caking, sieve, removing impurity;

29, Aspongopus: pick clean impurity, sieve removes earth, or uses with the micro-stir-fry of slow fire;

30, Testis et penis callorhini: catch buck when coastal ice cube cracking in spring, extract genitals, put cool place and locate air-dry;

31, Semen Litchi: get crude drug, removing impurity, the used time smashs to pieces;

32, Fructus Evodiae: get crude drug, removing fruit stem, branch and impurity, sieve removes chip;

33, Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put micro-stir-fry extremely yellow in pot, taking-up cools;

34, Semen Sinapis Albae: former medicine is winnowed with a dustpan most impurity, and fry to buff, micro-have fragrance and get final product;

35, Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries.

Two, prepare

1, by the Caulis Sargentodoxae of described weight, Radix Rhapontici, Fructus Crataegi, Carapax Trionycis, Herba Artemisiae Anomalae, Hirudo, Radix Xylosmae japonici, Radix Achyranthis Bidentatae, Herba Kalimeridis, Semen Coicis, Rhizoma Zingiberis, Rhizoma Chuanxiong, Rhizoma Corydalis, Endothelium Corneum Gigeriae Galli, Fructus Foeniculi, Herba Lycopodii, Rhizoma Curculiginis, Rhizoma Corydalis, Spina Gleditsiae, Cortex Lycii, Herba Patriniae, Fructus Toosendan, Colla Corii Asini, Squama Manis, Oletum Trogopterori, Radix Pseudostellariae, Flos abelmoschi manihot, Pollen Typhae, Aspongopus, Testis et penis callorhini, Semen Litchi, Fructus Evodiae, Fructus Hordei Germinatus, Semen Sinapis Albae, arnebia medicinal decocts with water secondary, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.

2, add water the medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 40 minutes, filter and to obtain second time decoction liquor.

3, by twice decoction liquor mixing and stirring, 6 doses are divided into take.

Medicine of the present invention has warming middle-JIAO by cold, nourishing YIN and supplementing blood, effect of promoting blood circulation and stopping pain, and treatment endometriosis instant effect, short treating period, do not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy endometriosis of the present invention

1, physical data

Accept endometriosis patients totally 207 examples for medical treatment.

2, diagnostic criteria

According to the difference of diseased region, and occur different symptoms, modal symptom is described below:

(1) dysmenorrhea and chronic hypogastralgia

Patient with the dysmenorrhea of Secondary cases, gradual aggravation for feature, based on hypogastric region and rectal tenesmus pain, can in premenstrual 1 ~ 2 day of the moon, disappear after menstruation, pain is from lumbosacral region, abdominal part, be radiated to vagina, perineum, anus or thigh, the degree of pain is relevant with the position of dystopy stove, but be not directly proportional to the size of focus, less dystopy tuberosity as jarjavay's ligaments position can cause the insufferable pain of patient, and larger ovarian endometrial cyst symptom is lighter or asymptomatic.The patient of 25% can painless warp, and 20% ~ 30% endometriosis patients has chronic hypogastralgia.

(2) menoxenia

The endometriosis patient of 15% can have menorrhagia, menostaxis or drop hemorrhage.Be due to ovary destroy by implantatior cyst, or ovary adhesion parcel cause ovarian dysfunction and cause menoxenia; Simultaneously patient is often associated with hysteromyoma or endometrioma also can cause menorrhagia or menostaxis etc.

(3) infertile

Endometriosis patients is often accompanied infertile, and has become one of infertile major reason.

(4) sexual anhedonia

The endometriosis patients of about 30% often tells sexual anhedonia.Many caused by mechanical irritation.Betide the endometriosis of douglas cul-de-sac, Rectovaginal septum, make surrounding tissue swelling, fibrosis, during sexual intercourse, make uterine contraction upwards ascending and pain occurs.The degree of sexual anhedonia is relevant with the position of endometriosis, as the dystopy tuberosity at sacral ligaments position, low fixing after metrosynizesis, the degree aggravation of the Tao Shi chamber person's of closing sexual anhedonia.

(5) bowel symptoms

If when Endometriosis focus is positioned near douglas cul-de-sac and rectum, in menstrual phase because focus is congested, edema, stimulation rectum causes rectal tenesmus and just frequency or defecation bitterly, also can occur constipation or diarrhoea.If focus invades rectal wall, and can cause stenosis of bowel or intestinal obstruction to when enteric cavity is outstanding or focus is larger.If it is comparatively dark that a few patients focus invades intestinal wall, reach muscle layer person, because local intestinal mucosa is congested, periodically stool band blood can appear in edema, not focus is invaded caused by intestinal mucosa.

(6) urinary Tract Symptoms

If when endometriosis focus is positioned at bladder and ureter, patient can have periodically frequent micturition, dysurea and hematuria.Endometriosis focus is rare at ureter, the Ureteric Obstruction slowly carried out many due to endometriosis of pelvis cause pelvic circumference tissue adhesion or larger endometrial implantatior cyst extruding, cause the distortion of ureter cicatrix, narrow or block.Because ureteral obstruction can form hydronephrosis and the repressive renal atrophy of Secondary cases.

(7) other position endometriosis symptoms

If when endometriosis plantation and growth occur at health other positions, all increase at diseased region generating period pain, hemorrhage and block thing, as focus betide umbilical part, stomach wall wound and external genital time.If when focus involves lung, pleura or diaphragmatic pleura, repeat catamenial pneumothorax occurs at intermenstrual period, when involving pulmonary parenchyma, premenstrual spitting of blood, dyspnea and (or) chest pain can be occurred.The endometriosis of brain is very rare, if occurred, can occur the headache of typical recurrent and nerve afunction phenomenon.

(8) acute abdomen symptom

Few ovaries endometrial implantatior cyst, in the moon, premenstrual or menstrual phase increases due to intraluminal pressure, cyst wall occurs and wears out, if cut is less, overflow is few, and stomachache can be alleviated gradually; If cut is comparatively large, capsule content overflows into abdominal cavity in a large number, then cause acute abdomen symptom, is the new problem of current department of obstetrics and gynecology neck threshold significant.Usually be misdiagnosed as torsion of the pedicle of ovarian cyst, ectopic pregnancy, appendicitis, diffuse peritonitis and row emergency operation, in art, just turn out to be Rupture of Ovarian Endometrioma.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 10 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: endometriosis transference cure, observe 1 year without bounce-back person;

Take a turn for the better: endometriosis symptom is obviously improved, and body constitution progressively strengthens;

Invalid: endometriosis symptom, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy endometriosis patients 207 example of the present invention, effective 194 examples of result, obvious effective rate is 93.72%, and take a turn for the better 10 examples, and improvement rate is 4.83%, and invalid 3 examples, total effective rate is 98.55%.

Claims (3)

1. treat a medicine for endometriosis, it is characterized in that: it is made up of the crude drug in following weight range:

Caulis Sargentodoxae 5-15 gram of Radix Rhapontici 10-20 Keshan short, bristly hair or beard 10-20 gram

Carapax Trionycis 10-20 gram of Herba Artemisiae Anomalae 5-15 gram of Hirudo 10-20 gram

The Radix Xylosmae japonici 10-20 gram of blue 5-15 gram of Radix Achyranthis Bidentatae 10-20 Rana nigromaculata

Semen Coicis 5-15 gram of Rhizoma Zingiberis 5-15 gram of Rhizoma Chuanxiong 5-15 gram

Rhizoma Corydalis 10-20 gram of Endothelium Corneum Gigeriae Galli 5-15 gram of Fructus Foeniculi 5-15 gram

Herba Lycopodii 5-15 gram of Rhizoma Curculiginis 3-9 gram of Rhizoma Corydalis 3-9 gram

Spina Gleditsiae 3-9 gram of Cortex Lycii 25-35 gram of Herba Patriniae 5-15 gram

Fructus Toosendan 10-20 gram of Colla Corii Asini 15-25 gram of Squama Manis 20-30 gram

Oletum Trogopterori 5-15 gram of Radix Pseudostellariae 5-15 gram of Flos abelmoschi manihot 3-9 gram

Pollen Typhae 8-15 gram of Aspongopus 10-20 gram of Testis et penis callorhini 5-15 gram

Semen Litchi 5-15 gram of Fructus Evodiae 3-9 gram of Fructus Hordei Germinatus 3-9 gram

Semen Sinapis Albae 5-15 gram of Radix Arnebiae (Radix Lithospermi) 10-20 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Caulis Sargentodoxae 10 grams of Radix Rhapontici 15 Keshan short, bristly hair or beards 15 grams

Carapax Trionycis 15 grams of Herba Artemisiae Anomalaes 10 grams of Hirudos 15 grams

Blue 10 grams of Radix Xylosmae japonici 15 grams of Radix Achyranthis Bidentatae 15 Rana nigromaculata

Semen Coicis 10 grams of Rhizoma Zingiberiss 10 grams of Rhizoma Chuanxiongs 10 grams

Rhizoma Corydalis 15 grams of Endothelium Corneum Gigeriae Galli 10 grams of Fructus Foeniculi 10 grams

Herba Lycopodii 10 grams of Rhizoma Curculiginises 6 grams of Rhizoma Corydalis 6 grams

Spina Gleditsiae 6 grams of Cortex Lycii 30 grams of Herba Patriniaes 10 grams

Fructus Toosendan 15 grams of Colla Corii Asini 20 grams of Squama Maniss 25 grams

Oletum Trogopterori 10 grams of Radix Pseudostellariaes 10 grams of Flos abelmoschi manihots 6 grams

Pollen Typhae 10 grams of Aspongopuss 15 grams of Testis et penis callorhinis 10 grams

6 grams, Semen Litchi 10 grams of Fructus Evodiaes 6 grams of Fructus Hordei Germinatus

Semen Sinapis Albae 10 grams of Radix Arnebiae (Radix Lithospermi)s 15 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Caulis Sargentodoxae: be soaked in water, cleans spare, runs through, and section, dries;

(2) Radix Rhapontici: pick clean impurity, unhairing is cleaned, and runs through, and section, dries;

(3) Fructus Crataegi: pick clean impurity, sieve enucleation;

(4) Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;

(5) Herba Artemisiae Anomalae: pick clean impurity, remove root, uses water edulcoration, slightly soaks, cutting, dry;

(6) Hirudo: clean, vexed soft, cutting, dries;

(7) Radix Xylosmae japonici: after autumn take root, cleans, and section, dries;

(8) Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

(9) Herba Kalimeridis: summer, autumn gather, using fresh herb or dry;

(10) Semen Coicis: get crude drug, removing residual cot, impurity;

(11) Rhizoma Zingiberis: pick clean impurity, be soaked in water 3-6 hour, pulls out, cuts into slices or dice, dry after moistening;

(12) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;

(13) Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

(14) Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;

(15) Fructus Foeniculi: get crude drug, removing impurity;

(16) Herba Lycopodii: sieve dedust bits, pick clean impurity, be cut into segment;

(17) Rhizoma Curculiginis: get clean Rhizoma Curculiginis yellow wine and mix thoroughly, after running through, puts micro-stir-fry in pot and, to dry, take out, dry, every Rhizoma Curculiginis 100 jin, with yellow wine 10-20 jin;

(18) Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

(19) Spina Gleditsiae: pick decontamination, is soaked in water, and runs through rear section, dries;

(20) Cortex Lycii: pick decontamination and core, slightly wash, cutting, dry;

(21) Herba Patriniae: get crude drug, removing impurity, with Water spray, slightly dries in the air, and cutting is dry;

(22) Fructus Toosendan: pick decontamination, cleans, and dries, grating or cleave in two;

(23) Colla Corii Asini: smash use to pieces;

(24) Squama Manis: get the Squama Manis sheet picking clean, separately size, separately puts sand in pot and makes popular, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;

(25) Oletum Trogopterori: pick clean impurity, smashes or sieves dedust bits;

(26) Radix Pseudostellariae: extract fibrous root, dry;

(27) Flos abelmoschi manihot: pick clean impurity, dry;

(28) Pollen Typhae: rub broken caking, sieve, removing impurity;

(29) Aspongopus: pick clean impurity, sieve removes earth, or uses with the micro-stir-fry of slow fire;

(30) Testis et penis callorhini: catch buck when coastal ice cube cracking in spring, extract genitals, put cool place and locate air-dry;

(31) Semen Litchi: get crude drug, removing impurity, the used time smashs to pieces;

(32) Fructus Evodiae: get crude drug, removing fruit stem, branch and impurity, sieve removes chip;

(33) Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put micro-stir-fry extremely yellow in pot, taking-up cools;

(34) Semen Sinapis Albae: former medicine is winnowed with a dustpan most impurity, and fry to buff, micro-have fragrance and get final product;

(35) Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;

(2) prepare

(1) by the Caulis Sargentodoxae of described weight, Radix Rhapontici, Fructus Crataegi, Carapax Trionycis, Herba Artemisiae Anomalae, Hirudo, Radix Xylosmae japonici, Radix Achyranthis Bidentatae, Herba Kalimeridis, Semen Coicis, Rhizoma Zingiberis, Rhizoma Chuanxiong, Rhizoma Corydalis, Endothelium Corneum Gigeriae Galli, Fructus Foeniculi, Herba Lycopodii, Rhizoma Curculiginis, Rhizoma Corydalis, Spina Gleditsiae, Cortex Lycii, Herba Patriniae, Fructus Toosendan, Colla Corii Asini, Squama Manis, Oletum Trogopterori, Radix Pseudostellariae, Flos abelmoschi manihot, Pollen Typhae, Aspongopus, Testis et penis callorhini, Semen Litchi, Fructus Evodiae, Fructus Hordei Germinatus, Semen Sinapis Albae, arnebia medicinal decocts with water secondary, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container,

(2) add water the medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 40 minutes, filter and to obtain second time decoction liquor;

(3) by twice decoction liquor mixing and stirring, 6 doses are divided into take.