CN103721140A - Traditional Chinese medicine preparation for treating bronchiectasia and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating bronchiectasia. The preparation comprises the following raw material medicines in parts by weight: 10-20 parts of Platycodon grandiflorum, 10-20 parts of apricot, 10-20 parts of Rhizoma Pinellinae Praeparata, 10-20 parts of Thunberg Fritillary Bulb, 10-20 parts of radix scrophulariae, 10-20 parts of the root bark of white mulberry, 10-20 parts of scutellaria baicalensis, 10-20 parts of circium japonicum, 10-20 parts of herba cepbalanoplosis segeti, 10-20 parts of radix stemonae, 10-20 parts of liquorice, 10-20 parts of burdock, 10-20 parts of dried radix rehmanniae, 10-20 parts of rhizoma polygonati, 10-20 parts of dogwood, 10-20 parts of salviae miltiorrhizae and 10-20 parts of white paeony root. The traditional Chinese medicine preparation has the effects of performing immunoregulation, resisting fibrosis, inhibiting mucus secretion and promoting peristalsis of stomach intestine; according to the diseased organs, the lung is considered seriously, and adjacent organs such as the spleen, liver, kidney and large intestine are considered. A patient suffering from bronchiectasia has the symptoms such as repeated cough, expectoration and hemoptysis, and the labor capacity and living quality of the patient are severely influenced. The traditional Chinese medicine preparation has an obvious effect of treating the symptoms such as expectoration and hemoptysis of the patient suffering from bronchiectasia and is an effective and low-cost preparation, and the living quality of the patient can be improved.

Description

A kind of bronchiectasic Chinese medicine preparation and preparation method thereof for the treatment of

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of bronchiectasic Chinese medicine preparation and preparation method thereof for the treatment of.

Background technology

Bronchiectasis (bronchiectasis) refers to that near-end median size bronchus is due to the destruction of muscle and the elastic component of tube wall, causes its tube chamber to form abnormal, irreversibility expansion, distortion.Primary disease majority is acquired, is more common in child and youth.Mostly be secondary to after acute and chronic respiratory tract infection and bronchial obstruction, patient has the medical histories such as young measles, pertussis or bronchopneumonia more.Clinical manifestation is mainly chronic cough, coughs a large amount of purulent sputums or repeatedly spit blood.

Bronchiectasic Etiological is Bronchi-pulmonary tissue infection and bronchial obstruction.Bronchiectasis may be also that congenital development obstacle and inherited genetic factors cause, but more rare.Separately have an appointment 30% bronchiectasis disease because of not bright, may hereditaryly with body, immune lose the factors such as unbalance or anatomic defect relevant.

Common virus and antibacterial infect and make that bronchial tube transmucosal is congested, edema, and block of secretion makes tube chamber narrow and small, cause inadequate drainage and increase the weight of to infect, and both influence each other, and impel bronchiectasic generation and development.Child's pertussis, measles, bronchopneumonia are the modal reasons of bronchiectasis due to Bronchi-pulmonary tissue infection.Because child's bronchus tube chamber is thin, tube wall is weak, easily blocks, and repeated infection destroys each layer tissue of bronchial wall, makes elasticity attenuation, or lung fibrosis around bronchioles, and tractive tube wall causes bronchus distortion expansion.Fibrous tissue tractive after the chronic infection of lung tissue or tuberculose focus healing, also can form bronchiectasis.In addition, tumor, foreign body suck or the lymph node of the outer enlargement of pipe is oppressed, and also can cause far-end Bronchi-pulmonary tissue infection and cause bronchiectasis.

Damaged and the inherited genetic factors of the congenital growth of bronchus is the congenital dysplasia of bronchus 1., as tracheobronchomegaly, may be that congenital connective tissue is abnormal, the expansion of tube wall due to weak.2. because of achondroplasia or elastic fiber deficiency, cause local tube wall weakness or elasticity poor, often, with sinusitis and situs inversus viscerum (dextrocardia), be called as Kartagener syndrome, often accompany bronchiectasis.3. the pulmonary cystic fibrosis relevant with inherited genetic factors and heritability α1 antitrypsin deficiency disease, all can have the retention of bronchus thick secretions, causes obstruction, pulmonary atelectasis and infection, brings out bronchiectasis.

Body's immunity imbalance bronchiectasis may be lacked of proper care relevantly with body's immunity, and humoral immune defect more easily occurs than cellular immunity deficiency.Humoral immune defect person, owing to lacking IgA and/or IgG antibody in its trachea-bronchia secretions, easily causes repeatedly virus or antibacterial to infect.In addition, found that at present the immune correlated diseases such as rheumatoid arthritis, Crohn disease, ulcerative colitis, systemic lupus erythematosus (sle), bronchial asthma and panbronchiolitis can be simultaneously with bronchiectasis.

Bronchiectasis can betide any age, but take teenager as common.Most patients once had measles, pertussis or bronchopneumonia protracted course of disease medical history children in year, and some bronchiectasis patients may be with chronic sinusitis or familial immunity defect medical history.

Bronchiectasic symptom: typical symptom is chronic cough, a large amount of purulent sputum and repeatedly spits blood.1, chronic cough, a large amount of purulent sputum, relevant with Body Position Change, this is because bronchiectasis position secretions stores up, while changing position, secretions stimulates bronchial mucosa to cause cough and expectoration.Being everlasting, rise morning or lie in bed night cough, expectoration amount while rotating position increase.While infecting acute attack, yellow green purulent sputum showed increased, can reach hundreds of milliliters every day, and as expectorant frowziness, prompting is associated with anaerobic infection.Sputum collecting standing rear feature that occurs layering in vial during infection: upper strata is foam, lower outstanding purulence composition, middle level is muddy mucus, lower floor is slough precipitate.The commonly encountered diseases substance that causes infection is Pseudomonas aeruginosa, staphylococcus aureus, hemophilus influenza, streptococcus pneumoniae and moraxelle catarrhalis.2, repeatedly spit blood.50%～70% patient has the spitting of blood of varying degree, spitting of blood varying degree, and spitting of blood amount and coincident with severity degree of condition, extent of disease are sometimes inconsistent.Some patients were, repeatedly to spit blood as unique symptom, without symptoms such as coughing, vomica, is called " dry bronchiectasis " at ordinary times clinically, and its bronchiectasis multidigit is in the good position of drain.3, recurrent pulmonary infection is characterized in that pneumonia protracted course of disease occur same lung section repeatedly.Due to often being spread by upper respiratory tract infection, there is the symptoms such as heating, cough aggravation, amount of expectoration increase, uncomfortable in chest, chest pain downwards.4, chronic infection poisoning symptom repeatedly secondary infection can have whole body poisoning symptom, as heating, weak, loss of appetite, become thin, anemia etc., can there is tachypnea and cyanosis in severe patient.Serious symptom bronchiectasis patient is due to bronchus around lung tissue suppurative inflammation and lung fibrosis widely, can concurrent obstructive emphysema, pulmonary heart disease, then there is corresponding symptom.

In addition, due to the lasting inflammatory reaction of bronchus, can there is reversible airflow obstruction and airway hyperreactivity in some patients were, show as pant, dyspnea and cyanosis.Bronchiectasis sign: early stage or dry bronchiectasis can be without abnormal physical signs of lung; the heavy or secondary infection of pathological changes often audible and pectus, back is fixed and the lasting thick moist sound of limitation; audible and wheezing sound sometimes, part chronic patients is with drumstick finger (toe).While there is the complication such as emphysema, pulmonary heart disease, there is corresponding sign.

Generally speaking, bronchiectasis is that the destructiveness on dissecting changes, is irreversible, so the target of Drug therapy is the progress of controlling symptom and delaying disease.Bronchiectasis is secondary to other diseases conventionally, so reply protopathy is treated in time, the sinusitis being combined etc. should thoroughly be treated., should strengthen Supporting Therapy, reasonable arrangement rest according to the state of an illness herein, should avoid suffering from cold, advice smoking cessation, preventing respiratory tract infection.

Infection control is the primary treatment measure of bronchiectasis acute infection period.According to the state of an illness, with reference to antibacterial culturing and drug sensitivity test result, select antibacterials, expectorant cultivation results out before or expectorant cultivate when negative, antibiotic can be selected following empirical scheme.Light disease person can select oral ampicillin or amoxicillin 0.5g, every day 4 times, or first and second in generation cephalosporin; While there is charrin disease, can select oral quinolones; Patient with severe symptoms, often needs combined with intravenous medication.If any anaerobe mixed infection, add with metronidazole (metronidazole) or tinidazole.Repeatedly show effect acute lower respiratory infection or massive hemoptysis, extent of disease is confined to a side lung, is no more than 2 lobes of the lung, and wayward through Drug therapy, systemic conditions is good, can make lung section or pulmonary lobectomy according to extent of disease.As lighter in pathological changes, and symptom is not obvious, or pathological changes more extensively involves bilateral pulmonary, or with serious Respiratory Function Impairments person, unsuitable operative treatment.

Product and medicine are not a lot of in the market, but for doctor trained in Western medicine, great majority are selected antibiotic therapy or the excision pathological changes lobe of the lung, the one, and price comparison is expensive, and effect is also not obvious, easily causes secondary infection.To patient, bring very large financial burden, to physical function, bring certain side effect; For the pure Chinese medicine on market, drug effect is slow, and formula compatibility does not have specific aim, unstable again.Needs of patients has a kind of life-time service, effective, is free from side effects again, and cheap Chinese herbal medicine formula preparation solves the problems referred to above.

Summary of the invention

Technical problem to be solved by this invention is, this patient recurrent cough, expectoration, spitting of blood have had a strong impact on patient's work capacity and quality of life.For this disease, doctor trained in Western medicine great majority are selected antibiotic therapy or the excision pathological changes lobe of the lung at present.The one, price comparison is expensive, and effect is also not obvious; The 2nd, easily cause secondary infection.To patient, bring very large financial burden, to physical function, bring certain side effect; For the pure Chinese medicine on market, drug effect is slow, and formula compatibility does not have specific aim, unstable again.The present invention can both pay attention to pulmonary lesion to effects such as immunomodulating, fibrosis, the secretion of inhibition mucus, short digestive tract powers from pathological changes internal organs, more take adjacent dirty spleen, liver, kidney, large intestine into account.Chinese medicine preparation of the present invention is to bronchiectasis patient expectoration, and hemoptysis symptom has significant therapeutic effect, and is a kind of effectively inexpensive preparation, improves patient's quality of life.

For solving the problems of the technologies described above, the invention provides a kind of bronchiectasic Chinese medicine preparation for the treatment of, described in it, in preparation, the parts by weight of various crude drug are: 10～20 parts of Radix Platycodoniss, 10～20 parts, Semen Armeniacae Amarum, 10～20 parts of Rhizoma Pinelliae Preparatum, 10～20 parts of Bulbus Fritillariae Thunbergii, 10～20 parts of Radix Scrophulariaes, 10～20 parts of Cortex Mori, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Cirsii Japonicis, 10～20 parts of Herba Cirsiis, 10～20 parts of the Radixs Stemonae, 10～20 parts, Radix Glycyrrhizae, 10～20 parts of Fructus Arctiis, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas.

The bronchiectasic Chinese medicine preparation of described treatment, described in it, in preparation, the parts by weight of various crude drug can be: 10～15 parts of Radix Platycodoniss, 10～15 parts, Semen Armeniacae Amarum, 10～15 parts of Rhizoma Pinelliae Preparatum, 10～15 parts of Bulbus Fritillariae Thunbergii, 10～15 parts of Radix Scrophulariaes, 10～15 parts of Cortex Mori, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Cirsii Japonicis, 10～20 parts of Herba Cirsiis, 10～20 parts of the Radixs Stemonae, 10～20 parts, Radix Glycyrrhizae, 10～20 parts of Fructus Arctiis, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas.

The bronchiectasic Chinese medicine preparation of described treatment, described in it, in preparation, the parts by weight of various crude drug can also be: 10～20 parts of Radix Platycodoniss, 10～20 parts, Semen Armeniacae Amarum, 10～20 parts of Rhizoma Pinelliae Preparatum, 10～20 parts of Bulbus Fritillariae Thunbergii, 10～20 parts of Radix Scrophulariaes, 10～20 parts of Cortex Mori, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Cirsii Japonicis, 10～15 parts of Herba Cirsiis, 10～15 parts of the Radixs Stemonae, 10～15 parts, Radix Glycyrrhizae, 10～15 parts of Fructus Arctiis, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Rhizoma Polygonatis, 10～15 parts of Fructus Corni, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of the Radix Paeoniae Albas.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of bronchiectasic Chinese medicine preparation, and the process for producing granula of described Chinese medicine preparation comprises the following steps:

A. described crude drug is put into pulverizer grinding and sieving,

B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;

C. get again the medicinal residues after above-mentioned ethanol extraction, add water heating and refluxing extraction 2 times;

D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying are dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.

In described step a, described crude drug can be put into after pulverizer is pulverized and cross 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves standby.

In described step b, particulate matter remaining after sieving can be put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution be merged standing; In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing.

In described steps d, above-mentioned two kinds of extracting solution can be merged to 1.38 filtrate when concentrating under reduced pressure relative density is 70 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of bronchiectasic Chinese medicine preparation again, the preparation process of the oral solutions of described Chinese medicine preparation is: all raw materials are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; Above-mentioned two kinds of extracting solution are merged, and it is concentrated that recovery ethanol is put into concentrator, adds dextrin and be in harmonious proportion, bottling.

Above-mentioned steps reclaims after ethanol decompression and puts into concentrator when concentrated, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

The bronchiectasic Chinese medicine preparation of described treatment, the dosage form for the treatment of bronchiectasic Chinese medicine preparation described in it can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plaster or cream.

This patient recurrent cough, expectoration, spitting of blood, had a strong impact on patient's work capacity and quality of life.The present invention can both pay attention to this dirty lung to effects such as immunomodulating, fibrosis, the secretion of inhibition mucus, short digestive tract powers from pathological changes internal organs, more take adjacent dirty spleen, liver, kidney, large intestine into account.Chinese medicine preparation of the present invention is to bronchiectasis patient expectoration, and hemoptysis symptom has significant therapeutic effect, and is a kind of effectively inexpensive preparation, improves patient's quality of life.This technology has convenient drug administration, through patient part, the advantage such as targeting is strong, and medicament is easy to manufacture, with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, without any side effects, easy to use, after curing, be difficult for recurrence, and cheap, easy to use, can create good social value and economic interests.

The specific embodiment

Bronchiectasis (being called for short an expansion) is common chronic bronchial disease, refer to that diameter is greater than the medium sized proximal bronchus of 2mm because muscle and the Elastic tissue of tube wall are destroyed the abnormal expansion causing, cardinal symptom is chronic cough, cough a large amount of purulent sputums and (or) repeatedly spit blood, patient has the medical histories such as young measles, pertussis or bronchopneumonia more.Bronchiectasis belongs to the categories such as Chinese medicine " cough " " hemoptysis ", " lung abscess ".In recent years, a lot of traditional Chinese medical science scholars have carried out comparatively deep research to its etiology and pathogenesis and method for the treatment of, have obtained gratifying achievement.

Etiology and pathogenesis: one, acute attack stage pathogen and pathology of tcm.1, burning hot.Liver-fire invading the lung is the key factor that morbidity is expanded in impact in acute stage, can be divided into excess-fire, asthenic fire.Irritability is prosperous in the spring, autumn-dryness disease impairing the lung or pathogenic fire derived from stagnation of liver-QI, and liverzang-fire attacking lung, the liver-fire perverse and unreasonable manner insult lung lung network of all can burning causes spitting of blood; < < Jing Yue's complete work > > blood disorder is said: " all blood disorders of controlling; must know that it wants, and blood moving by, fire gas ear only only; have fire without fire therefore look into fiery person but look into it, the person that looks into gas but look into its deficiency of vital energy QI excess ".Excess-fire is worked as to clearing away heat-fire, and asthenic fire is worked as nourishing YIN to lower pathogenic fire; Hyperactivity of fire caused by deficiency of YIN is asthenic fire, and gas fire is contained prosperous, and liquid consumption is hindered in lung-dryness syndrome due to deficiency of YIN or prolonged illness or calentura Tianjin, and the deficiency of YIN is hyperactivity of fire, or the plain body deficiency of YIN, deficiency-fire produced in the interior, the absurd row of forcing blood and cause hemorrhage.Wang Shi thinks lung being a delicate viscus, preferring moisture to dryness, and bronchiectasis is many, and because with the passing of time being invaded by exogenous pathogen does not heal, pathogen is amassed in lung, and strongly fragrant heat-transformation of a specified duration, decocts body fluid in lung, causes body fluid deficiency liquid consumption, hyperactivity of fire caused by deficiency of YIN, the lung network of burning, forcing blood is excessive and cause.

2, expectorant heat.Exopathogen is violated lung, and lung loses Xuan Fasu and falls, and regulating fluid apssage is unfavorable, and gas is cloth Tianjin not, raw in phlegm-damp, on note in lung, i.e. " the spleen being the source of producing phlegm, the lung being the utensil for storing phlegm ", spleen is source of generating QI and blood, and the pivot of rising and falling of QI is liked dry evil wet, pneumonopathy and spleen, illness of child viscera affecting mother one, dysfunction of the spleen in transportation, the defeated cloth imbalance of body fluid, raw in phlegm-damp, or the pungent savoury of surfeit, interior-heat is decocted bright body fluid, and poly-liquid is expectorant, stagnation of phlegm-damp in middle-JIAO, of a specified duration Yu Huare, the expectorant hot smoking lung network that burns, the absurd row of forcing blood and cause primary disease.Shi Shi " think that expectorant is the product of bronchitis, closely related with Chinese medicine " lung-heat ", and think that the expectorant source of primary disease mainly contains four ends: dysfunction of the spleen in transportation, raw in phlegm-damp; Hyperactivity of fire caused by deficiency of YIN, Tianjin refining expectorant burns; Pathogenic fire derived from stagnation of liver-QI, strongly fragrant in phlegm-fire; Element body is not enough, being invaded by exogenous pathogen.

3, blood stasis.The common machine that stays the stasis of blood in expand developing, various middle because burning hot expectorant is empty, cause burn lung network or disorder of QI movement, the deficiency of vital energy lose take the photograph all can the hyperamization stasis of blood disease, as vomit the thick expectorant of a large amount of Huangs, its taste is stench, take that get up morning or when night is sleeping as many, uncomfortable in chest, spitting of blood color is dim red, or bloody sputum, or squamous and dry skin, or cyanosis of the lips and nails, dim complexion, there is ecchymosis on red tongue or limit, and at the bottom of tongue, vein is tortuous etc.

Two, catabasis pathogen and pathology of tcm.Bronchiectasis is many because with the passing of time being invaded by exogenous pathogen does not heal, and pathogen is stayed in lung, and strongly fragrant heat-transformation of a specified duration, decocts body fluid in lung, causes body fluid deficiency liquid consumption, course of disease delay, and prolonged illness impairment of YIN, hyperactivity of fire caused by deficiency of YIN, the lung network of burning, forcing blood is excessive and cause.Due to YIN-deficiency of the lung and kidney, cloudy without made, hyperactivity of deficient fire causes primary disease recurrence.Catabasis is main mainly with lung, spleen, deficiency of kidney-QI, and the deficiency of the lung is basic for it." if think, natural endowment is not enough, or prolonged illness strain, all can occur the card of lung qi Yin bivacuity, and the deficiency of the lung easily recruits heresy to invade, thereby makes disease repeatedly, a little less than common shape body slimming, often has the diseases such as inability to breathe regularly due to shortness of breath, dyspnea with rapid and short breath, therefore that the deficiency of the lung is primary disease is basic for Cao Shi.Lung governing regulation of water passages, if insufficiency of lung-QI, the miopragia of regulating fluid apssage.Water liquid stops gathering in lung system, with abnormal rising of lung-QI, and occurs expectoration; Heresy is stopped up in lung.Strongly fragrant and heat-transformation, stops up in expectorant heat, and refining liquid is expectorant, and expectorant yellow skin is thick; If injury of blood vessel of the lung by heat, network blood trouble is overflow, and can cause spitting of blood; Outside blood oozing from the body openings or subcuta neous tissue arteries and veins, form blood stasis." think that the generation of primary disease and physical factors are closely related, patient belongs to the body of insufficiency of lung-QI, deficiency of lung-YIN or deficiency of both QI and YIN to Zhu Shi more.Insufficiency of lung-QI, declares respectful not normal persistent cough, and gas not cloth Jin Zejin is polymerized to expectorant; Deficiency of lung-YIN, lung loses to moisten supports the few expectorant of dry cough, body fluid deficiency hyperactivity of fire and network wound spitting of blood ".If disease further develops, or illness of child viscera affecting mother one and lung spleen be with sick, or the kidney usually involved in chronic disease and deficiency of both the lung and kidney all can make the symptom of coughing, spit, spitting blood increase the weight of.Because of lung, this is tender dirty again, and innate deficiency is subject to exopathogen invasion and attack further.Exopathogen is violated lung often can lure bronchiectasis acute attack into, wherein especially with wind heat, wind and cold, that lung is violated in wind-dryness is the most common.Shi Shi thinks the spleen being the source of producing phlegm, especially the source of vital function.Temper is healthy and vigorous, and native metallographic is raw, and healthy energy is vigorous, and lung qi enriches, heresy diseases caused by exogenous pathogenic factor not.In addition, the insufficiency of the spleen wood insult that is subject to, because liverzang-fire attacking lung is easy to cause spitting of blood, therefore " seeing the disease of liver, knowing the liver disease will be transmitted into the spleen, in the ban tonifying the spleen ".Therefore, it is its mark that Shi Shi proposes phlegm-heat accumulated in the lung, and insufficiency of the spleen mistake fortune is it, and insufficiency of the spleen lung-heat is the important pathogenesis of primary disease.Hong Guangxiang thinks that primary disease basic pathogenesis is deficiency in origin and excess in superficiality, and asthenia of pulmonosplenic qi is this, expectorant, the stasis of blood, hot for marking, and opinion " control expectorant and first control spleen ", invigorating the spleen for dissipating phlegm, with exhausted the source of producing phlegm, is paid attention to warm logical, using warming and heat-clearing simultaneously.

Method for the treatment of research: primary disease deteriorated case transforms more, the state of an illness easily repeatedly, comparatively keep in check by treatment.Along with to primary disease research progressively deeply, emerged in large numbers many new method for the treatment of, but sum up mainly by through the treatment of proved recipe plus-minus, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs and treatment by stages several.

From domestic nearly ten She's year Chinese medicine Research Literatures, the tcm clinical practice worker in this field controls existing more exploration and research to the pathogenesis card of primary disease at present, when primary disease acute attack, paying attention to strongly fragrant in being invaded by exogenous pathogen, phlegm-damp, liverzang-fire attacking lung, expectorant heat, to stay the stasis of blood be trouble, more pay attention to deficiency in origin and excess in superficiality, deficiency in origin aspect stress " insufficiency of pectoral QI, temper virtual loss; from acute attack to catabasis evolution process, pay attention to lapsing to of the expectorant cloudy wound of heat.From pathological changes internal organs, both paid attention to this dirty lung, more take adjacent dirty spleen, liver, kidney, large intestine into account.In method for the treatment of, various places expert is in conjunction with exploration to primary disease pathogenesis rule, mostly adopts from intending doing plus-minus treatment through proved recipe and according to change of illness state is suitable, and also with good grounds primary disease feature is carried out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs by stage of attack and catabasis.In a word, fully demonstrated the characteristic that Syndrome Differentiation of Chinese Medicine is controlled, both emphasized that individuation opinion controlled, propose again general character card and controlled rule, both pay attention to stage and distinguished and control, and also had whole dynamically distinguishing to control characteristic simultaneously, for the bronchiectasic clinical research of Chinese medicine provides useful inspiration.

Radix Platycodonis: bitter in the mouth; Pungent; Property is put down.Lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.Radix Platycodonis is China tradition parts of generic medicinal plants, and the functions such as effect has lung qi dispersing, eliminates the phlegm, sore-throat relieving, evacuation of pus, cure mainly the symptoms such as cough with copious phlegm, laryngopharynx swelling and pain.Medicine-food two-purpose, demand is larger.< < property of medicine opinion > >: control the inferior dysentery, removing blood stasis, removes pneumatosis, removing food stagnancy is poly-, sputum, main lung-heat tachypnea is coughed contrary, except cold type of pain in abdomen, main attacked by pestiferous factors and pediatric epilepsy scared.< < Japan hanako materia medica > >: lower all gas, stop cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, mends five kinds of over strain, foster the spirit of nobility, evil removing is warded off temperature, tonify deficiency expectorant, broken lump in the abdomen, the evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat.

Semen Armeniacae Amarum: hardship, tepor; The bitter warm lung qi dispersing of Semen Armeniacae Amarum, loosening bowel to relieve constipation, is only suitable for the trouble of the excess syndromes such as ailment said due to cold or exposure, dryness of the intestine.All the moon loses, stagnated fire person, and unsuitable single medicinal material is for oral administration for a long time.As the disease taboo single medicinal materials such as pulmonary tuberculosis, bronchitis, chronic enteritis, dry cough without phlegm take for a long time.There is the effects such as lung moistening, cough-relieving, laxation, the diseases such as dry cough without phlegm, chronic cough of deficiency lung are had to certain mitigation.The nutritional labelings such as Semen Armeniacae Amarum rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum.Wherein the content of carotene is only second to Fructus Mangifera Indicae in fruit, and people are called anticancer fruit by Semen Armeniacae Amarum.Semen Armeniacae Amarum contains abundant fatty oil, has the effect that reduces cholesterol, and therefore, Semen Armeniacae Amarum has good effect to control cardiovascular system diseases; Chinese medicine theory thinks, Semen Armeniacae Amarum has the effect of promoting the production of body fluid to quench thirst, lung moistening Dingchuan, is usually used in the dryness of the lung patient's health care and the treatment such as breath with cough.

Rhizoma Pinelliae Preparatum: the Rhizoma Pinelliae is the tuber of the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.).Because it is poisonous, mostly be and concoct rear use.Cure mainly drying dampness to eliminate phlegm.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.Rhizoma Pinelliae Preparatum has the effect of drying dampness to eliminate phlegm, and Rhizoma Pinelliae Preparatum has the effect for the treatment of dry laryngopharynx, abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, and all blood disorders and deficiency of YIN cough caused by dryness, Tianjin are hindered thirster and avoided the instructions about how to take medicine Rhizoma Pinelliae, the careful instructions about how to take medicine Rhizoma Pinelliae of anemia of pregnant woman.

Bulbus Fritillariae Thunbergii, latin name Bulbus Fritillariae Thunbergii.Bitter in the mouth; Cold in nature.Gui Jing: return lung; Heart channel.Removing heat-phlegm; Dissipating depression of QI eliminating stagnation.For wind heat, scorching or phlegm-heat cough.This product merit is partial to hardship like Bulbus Fritillariae Cirrhosae and is let out.Control cough due to pathogenic wind-heat, Chang Peiwu Folium Mori, Radix Peucedani etc.Control phlegm-heat cough, Chang Peiwu Fructus Trichosanthis, the Rhizoma Anemarrhenae etc.Antitussive: peimine and peiminine 4mg/kg gavage, mice ammonia is drawn and coughed inhibitory action, 4mg/kg subcutaneous injection draws to cough to electricity irritation anesthetized cat superior laryngeal nerve also antitussive effect.The positive > > of < < book on Chinese herbal medicine: great order lung abscess lung withers, cough with asthma is spitted blood, and mental disorder, falls most in epistaxis, kind relieving stagnation, the pain that relieves the pain, relieving distension is full, clearing away liver-fire, cloudy knowledge, except seasonal epidemic pathogens dysphoria with smothery sensation, jaundice stranguria with urinary obstruction, the hematuria of having blood in stool; Relieving heat toxin, kills parasites and treats sore throat, scrofula, and acute mastitis carbuncle on the back, all carbuncle and ulcer toxic swellings, damp and hot malignant boil, anal fistula, incised wound is hemorrhage, burn pain, than Bulbus Fritillariae Cirrhosae, the merit of falling clearly, not less than several times.

Radix Scrophulariae sweet in the mouth, hardship, one-tenth; Cold nature.Return lung, stomach, kidney channel.Can join the army by pathogenic warmth, the pericardium that caves in, maculae caused by violent heat pathogen, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.Cure mainly: epidemic febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency not awake, Tianjin hinder constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore.Radix Scrophulariae: both equal energy clearing away heat and cooling blood of Radix Rehmanniae, YIN nourishing and the production of body fluid promoting, enters nutrient blood with controlling heat, consumption of YIN caused by febrile disease, the cards such as yin asthenia generating intrinsic heat, Chang Xiangxu is for using.But Radix Scrophulariae eliminating fire and detoxication power is stronger, therefore laryngopharynx swelling and pain, phlegm-fire scrofula is multiplex; Radix Rehmanniae clearing away heat and cooling blood power is larger, therefore heat in blood is hemorrhage, interior-heat is quenched one's thirst multiplex.Antibacterial action in vitro, Radix Scrophulariae has inhibitory action to trichophyton mentagrophytes, acrothesium floccosum and ulotrichy microspore tinea bacterium. and Radix Scrophulariae water logging agent (1: 3) also has inhibitory action to Austria Du big belly microspore tinea bacterium in vitro. and experiment shows: the inhibitory effect beguine of Radix Scrophulariae leaf is strong, wherein particularly evident to staphylococcus aureus. the positive > > of < < book on Chinese herbal medicine: Radix Scrophulariae, this thing bitter in the mouth and sweet, hardship can be relieved inflammation or internal heat, sweet energy YIN nourishing, with its sweet in the mouth, therefore falling property is also slow.< < book on Chinese herbal medicine > > says that it only enters kidney channel, and does not know that it walks lungs especially, therefore can move back the fire that unrooted swims, loose whole body expectorant stagnation of pathogenic heat carbuncle.

Cortex Mori is the root bark of moraceae plants Mulberry Morus alba L..Main product in Anhui, the ground such as Henan, Zhejiang, Jiangsu, Hunan.Effect: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.< < property of medicine opinion > >: make, flat.Can control lung qi dyspnea with fullness of the chest, aqueous vapor edema, main wound is exhausted, dredging water passages, the aqueous vapor that disappears, the headache of asthenia exopathogenic heat, interior tonifying for the deficiency.< < Japan hanako materia medica > >: temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards.Expectorant is quenched the thirst, sharp intestine and small intestine, and appetizing, lower food, kills abdomen and hides worm, and only cholera is vomited and diarrhoea.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect.< < Bencao Jingshu > >: Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.Radix Scutellariae has antiallergic action and antiinflammatory action: the contained baicalin of Radix Scutellariae and baicalin can obviously suppress the anaphylaxis contractile response that sensitized guinea pig rat small intestine in vitro and isolated tracheal produce antigen, to the passive general allergy of Cavia porcellus and mice and Cavia porcellus passivity skin allergic reaction, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, most evidences, and the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and due to being combined with multiple poisonous substance.10 milligrams of LD50 that can improve strychnine of baicalin reach 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

Radix Cirsii Japonici: latin name Herba seu Radix Cirsii Japonici.Cool in nature, sweet in the mouth, hardship, nontoxic.GUIXIN, Liver Channel.Function is controlled haematemesis, epistaxis, hematuria, stranguria with blood, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, acute appendicitis, carbuncle and ulcer toxic swelling, furuncle.The infusion of pharmacology Radix Cirsii Japonici, ethanol one infusion and alcohol leaching liquid, test in anesthetized animals such as Canis familiaris L., cat and rabbits, proves hypotensive activity.The same test of Herba Cirsii, proves that the more remarkable and lasting large and small Ji of hypotensive activity function all has heat-clearing and toxic substances removing, antiinflammatory, hemostasis and the effect that recovers liver function, promotion liver cell regeneration, be applicable to acute calenture struvite hemorrhage, yellow cellulitis, hepatitis, pyretic stranguria, hematuria etc.When antibacterial action root decoct or 1: 4000 concentration of herb distillate, can suppress the growth of human-like poisonous tulase in vitro. ethanol preserved material has inhibitory action to mycobacterium hominis at 1: 3000 o'clock. and the Mlc of water decoction is large than the concentration of ethanol preserved material. and Chinese medicine thinks that Radix Cirsii Japonici nature and flavor are sweet, cool, has the effect of removing heat from blood, hemostasis, blood stasis dispelling, subduing inflammation.According to the study, Radix Cirsii Japonici can reduce blood pressure, and tulase etc. is had to better inhibitory action.

Herba Cirsii: Latin literary fame: Herba Cirsii Setosi, has another name called field thistle (formal name used at school: Cirsium setosum) be the plant of Compositae Cirsium.Sweet, bitter, cold.GUIXIN, Liver Channel.Function with cure mainly: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, to spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.Decoct has certain inhibitory action to Hemolytic streptococcus, streptococcus pneumoniae and diphtheria corynebacterium in vitro.Ethanol preserved material has inhibitory action to mycobacterium hominis at 1: 30000 o'clock, but water decoction is larger more than 300 times than this to the Mlc of tulase.< < Tang materia medica > >: large and small Ji all can removing blood stasis, but Radix Cirsii Japonici holds concurrently and treats carbuncle, and the special main blood of Herba Cirsii can not be subsided a swelling also.< < book on Chinese herbal medicine is asked former > >: Radix Cirsii Japonici, Herba Cirsii two taste roots, leaf, and all bitter sweet gas is flat, can rise and can fall, and energy removing blood stasis, can stop blooding again.Herba Cirsii is sweet flat victory, very bitter, specially to bring down a fever, is tired of, make the clear and blood of fire return through, be to protect blood to be removing heat from blood.

Radix Stemonae nature and flavor are sweet, bitter, tepor.Return lung meridian.Cure mainly nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.For new chronic cough, cough, pulmonary tuberculosis cough, pertussis; Outward for head louse, body louse, enterobiasis, pudendum Pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.< < Bencao Jingshu > >: Radix Stemonae, < < another name for Sichuan Province this > > cloud is slightly cold, the sub-> > speech of < < solar corona is bitter, and < < herbal classic > > speech tepor person mistake also.Bitter and under let out, therefore kind, fall, lung qi rises to breathe heavily and coughs, and controls cough with dyspnea therefore kind.The loose lung-heat of energy, therefore the main lung moistening of < < property of medicine opinion > >.Its property is longer than parasite killing, passes corpse and steams labor, often has worm, therefore also lead it.Infantile malnutrition with fever has worm, and ascarid, proglottid of tapeworm, pinworm, all can kill it.Radix Stemonae bitter in the mouth, the weak people of insufficiency of the spleen stomach should hold concurrently and protect the same use of spleen peace stomach medicine, the multitudinous gas that do not injure one's stomach.

Radix Glycyrrhizae sweet in the mouth, property is flat, nontoxic.Function cures mainly: treating disorders in five ZANG-organs six internal organs cold and heat pathogen, and hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, the ripe use exterior cold of fall apart, goes pharyngalgia, except pathogenic heat, delays healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.Radix Glycyrrhizae property is flat, and sweet in the mouth, returns 12 warps.Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency removing toxic substances, mediation hundred medicines.Clinical practice divides " raw using " and " processed with honey " not.Raw with curing mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and large loose stool is thin, weak heating and cough, cardiopalmus etc.Can coordinating the actions of various ingredients in a prescription.

Fructus Arctii, Latin formal name used at school: Fructus Arctii, acrid in the mouth; Bitter; Cold in nature.Return lung; Stomach warp.For Compositae biennial herb plant Fructus Arctii (formal name used at school: dry mature fruit Arctium lappa L.).Have another name called Fructus Arctii, FRUCTUS ARCTII, evil reality etc.The infructescence of gathering during fruit maturation autumn, dries, and lays fruit, removes impurity, then dries.Raw using or stir-fry use, the used time smashs to pieces.Can control anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; Sore swollen toxin and mumps etc.Raw with can loosening bowel to relieve constipation, pyretic toxicity red swelling and pain of throat, has constipation with heat retention concurrently especially suitable.There is dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, the effect of removing toxic substances and promoting subsidence of swelling.Belong to wind-heat-dispersing medicinal in diaphoretic medicine.Modern study, Fructus Arctii also can be used for preventing and treating diabetic nephropathy; The arctigenin that Fructus Arctii fruit generates through hydrolysis containing arctigenin has active anticancer.< < property of medicine opinion > >: except all wind, remove erysipelas, main improving eyesight, Li Yaojiao, again loose all tuberositys, muscles and bones dysphoria with smothery sensation poison.

Fructus Corni, cures mainly pathogen cold and heat under the heart, and warming middle-JIAO, by cold warm numbness, goes three worms, the merit that for a long time clothes have been made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stopped dribbling urination; Take for a long time improving eyesight, brute force all the year round.Fructus Corni, has another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., is the conventional rare Chinese medicine of China, and applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties use that medical science is liked.Zhang Zhongjing be take Fructus Corni and has been formulated " JINGUI SHENQI WAN " as monarch.According to chemical analysis, Fructus Corni contains the effective ingredient such as cornin, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin that physiologically active is stronger, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is Herba indigoferae Pseudotinctoriae conventional in tcm clinical practice.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. < < detailed outline > > carries: Radix Salviae Miltiorrhizae, press the sensible opinion of < < married woman > > cloud, SIWU TANG is controlled gynecopathy, pay no attention to antenatal puerperal, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls, stops metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

The Radix Paeoniae Alba, clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control that the stagnant amenorrhea of the stasis of blood, hernia abdominal mass gather, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.The Radix Paeoniae Alba minute excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between are use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, minute excess-heat that can purify the blood, can control fever due to yin deficiency again; And the Radix Paeoniae Alba can only, for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.< < herbal classic > >: main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.

Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, the interior-heat disease such as quench one's thirst.Very effective in cure for diabetes.Stir-baked RHIZOMA POLYGONATI with yellow rice wine claims again to process Rhizoma Polygonati.For steaming rear section with adjuvants such as wine and Semen sojae atricolors, clean Rhizoma Polygonati dries the person of being used as medicine.Have the merit of the meridians of escaping concurrently.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, and blood fat reducing, atherosclerosis, slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough of YIN-deficiency of the lung and kidney etc.For weakness of the spleen and stomach.Both tonifying spleen-yin, strengthening the spleen gas again, for deficiency of kidney essence, obtain dizzy, soreness of the waist and knees, early whitening of beard and hair and quenching one's thirst etc.Rhizoma Polygonati strengthening bone and muscle, beneficial marrow, bleaches and sends out; The cough expectorant being suitable for due to lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.With respect to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, and all right yin nourishing is used for treating yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect, every blood system to have the people of thermal burn the moon to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., can often take.If want to treat epidemic febrile disease, can do qingying decoction with the Radix Rehmanniae; If the later stage for the treatment of epidemic febrile disease, because She's heat does not also disappear to the greatest extent, should be used for boiling QINGHAOBIEJIATANG the Radix Rehmanniae; In addition, for heat in blood poison, contain, macule purple is black, and the serious heat of epidemic febrile disease enters the symptom of nutrient blood, can take the Sisheng Wan that the Radix Rehmanniae is made; The general YIN nourishing and the production of body fluid promoting of wanting treats that interior-heat quenches one's thirst with constipation, should eat the once liquid soup that the Radix Rehmanniae boils.

Process for producing granula of the present invention is: get raw material Radix Platycodonis 1000g, Semen Armeniacae Amarum 1000g, Rhizoma Pinelliae Preparatum 1000g, Bulbus Fritillariae Thunbergii 1000g, Radix Scrophulariae 1000g, Cortex Mori 1000g, Radix Scutellariae 1000g, Radix Cirsii Japonici 1000g, Herba Cirsii 1000g, Radix Stemonae 1000g, Radix Glycyrrhizae 1000g, Fructus Arctii 1000g, Radix Rehmanniae 1000g, Rhizoma Polygonati 1000g, Fructus Corni 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Paeoniae Alba 1000g.Get in the water that described crude drug adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid,, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, stand for standby use, becomes component 1; The medicinal residues that water extraction is crossed are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, stand for standby use, becomes component 2; Above-mentioned two kinds of component pastes are condensed into pasty state, add after Mel or dextrin are in harmonious proportion and put into granulator, after granulating, with ultraviolet disinfection, then pack.

The preparation method of pill of the present invention is: get raw material Radix Platycodonis 1200g, Semen Armeniacae Amarum 1300g, Rhizoma Pinelliae Preparatum 1100g, Bulbus Fritillariae Thunbergii 1300g, Radix Scrophulariae 1200g, Cortex Mori 1200g, Radix Scutellariae 1300g, Radix Cirsii Japonici 1200g, Herba Cirsii 1200g, Radix Stemonae 1300g, Radix Glycyrrhizae 1300g, Fructus Arctii 1300g, Radix Rehmanniae 1100g, Rhizoma Polygonati 1200g, Fructus Corni 1300g, Radix Salviae Miltiorrhizae 1300g, Radix Paeoniae Alba 1300g.Drop into pulverizer and be ground into fine powder, granularity is 100～120 orders; Sieve, unsifted coarse granule adds 20 liters, water and soaks 45 minutes, and heated and boiled 35 minutes, filters filtrate for later use; Filtering residue adds water and heats for the second time, boils 35 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 45 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, put into after 80 ℃ of oven dry of baking oven cooling, and the fine powder sieving; Add Mel mediation and be twisted into pill.

The preparation method of oral solutions of the present invention: by all raw material Radix Platycodonis 1300g, Semen Armeniacae Amarum 1300g, Rhizoma Pinelliae Preparatum 1100g, Bulbus Fritillariae Thunbergii 1300g, Radix Scrophulariae 1200g, Cortex Mori 1200g, Radix Scutellariae 1300g, Radix Cirsii Japonici 1200g, Herba Cirsii 1200g, Radix Stemonae 1300g, Radix Glycyrrhizae 1300g, Fructus Arctii 1300g, Radix Rehmanniae 1100g, Rhizoma Polygonati 1300g, Fructus Corni 1300g, Radix Salviae Miltiorrhizae 1200g, Radix Paeoniae Alba 1200g.Put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, merges standing by 2 extracting solution; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; Above-mentioned two kinds of extracting solution are merged to the concentrated dextrin that adds and be in harmonious proportion, bottling.Above-mentioned steps reclaims after ethanol decompression and puts into concentrator when concentrated, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

Pharmacology's toxicity test

One, skin irritation test

1, experimental technique

Guinea pig back spinal column both sides are evenly coated depilatory, make approximately 20 square centimeters of unhairing scopes.Clean depilatory returns cage to observe 24 hours, and every group of Cavia porcellus is coated with respectively the present invention's honey refining pill 4,8 and 12g, and respectively containing crude drug 92mg, 184mg and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment finishes, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin are done pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity activity, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast more also no significant difference of word.

Results suggest, Chinese medicine preparation of the present invention, without local irritant effect, also has no general toxicity performance.Show that Chinese medicine preparation of the present invention is used safety.

Two, animal acute toxicity test research:

Tablet of the present invention, through trial test, can not be measured LD50, therefore measure maximum dosage-feeding.Adopt rectally approach, the maximum dosage-feeding on the one that records mice is 62.7g/kg (in medicated powder), be about 1567.5 times (people is in 60kg) intending clinical people's consumption, the maximum dosage-feeding 62.7g/kg (in medicated powder) on the one of rat, is about and intends 1567.5 times of clinical people's consumption.The equal Continuous Observation of laboratory animal one week, its outward appearance sign, the mental status, diet, drinking-water, feces etc. are showed no obvious abnormalities.When experiment finishes, animal is healthy survival all, and body weight increases.

Three, long-term toxicity test for animals research:

It is high that medicine of the present invention is established in this test, in, low dose group and substrate matched group, blank group, adopt rectally approach to give rat, dosage is respectively 3.2, 2.4 and 1.6g/kg (in medicated powder), be equivalent to intend 80 of clinical patient consumption [0.04g (medicated powder)/kg], 60 and 40 times, successive administration 2 months, in administration process, the body weight of each administration group and matrix group rat, dietary amount, outward appearance sign, behavioral activity, the mental status, hair color, feces character and the comparison of blank group, no significant difference (P > 0.05), the weight of animals increasing value and Main Organ Coefficients and blank group comparing difference be remarkable (P > 0.05) not, hematology and the indivedual indexs of blood parameters check result administration group and blank group comparing difference be (P < 0.05) significantly, but convalescent period finishes rear discrepant hematology and blood parameters has all recovered normal, other indexs and blank comparing difference be remarkable (P > 0.05) not, administration phase and convalescent period histological examination high dose group animal main organs and blank group relatively have no notable difference, having no slowness toxicity occurs.。

Clinical trial:

Bronchiectasis is clinical common chronic respiratory tract disease, and patient recurrent cough, expectoration, spitting of blood have had a strong impact on patient's work capacity and quality of life.This research, by observing the therapeutical effect of Long-term Oral Chinese medicine preparation to the bronchiectasis patient of follow-up, is intended to find a kind of effectively inexpensive approach to improve patient's clinical symptoms, improves patient's quality of life.

Description of test: two groups of patient diagnosis are clear and definite, before treatment, indices is similar.Be bronchiectasis patient.Voluntary participation.Matched group: 12 examples give oral erythromycin 0.125mg, every day 3 times, ambroxol 30mg, every day 3 times, 2 of Asmetons, every day 3 times, 52 weeks courses for the treatment of.Treatment group 12 examples, use Chinese medicine preparation of the present invention, and side uses: Radix Platycodonis 12g, Semen Armeniacae Amarum 13g, Rhizoma Pinelliae Preparatum 11g, Bulbus Fritillariae Thunbergii 13g, Radix Scrophulariae 12g, Cortex Mori 12g, Radix Scutellariae 13g, Radix Cirsii Japonici 12g, Herba Cirsii 13g, Radix Stemonae 12g, Radix Glycyrrhizae 13g, Fructus Arctii 14g, Radix Rehmanniae 11g, Rhizoma Polygonati 12g, Fructus Corni 13g, Radix Salviae Miltiorrhizae 13g, Radix Paeoniae Alba 13g.

Result treatment group and matched group comparison, amount of expectoration obviously reduces, treatment group before treatment with treatment after 8 weeks amounts of expectoration reduce difference and matched group relatively have a notable difference (P < 0.001).Have no adverse reaction.

Clinical data

One, entering to organize case is in May, 2009-2012 year May, the bronchiectasis patient that classic clinical symptoms and pulmonary's high resolution ct confirm.When selected without heating, asthma, spitting of blood, chest pain symptom, wherein to Macrolide and theophylline allergy sufferers, gestation person's age of sucking, hepatic and kidney function obstacle person, can not the person of following up a case by regular visits to all give eliminating.Totally 22 examples, are follow-up patient, male 15 examples wherein, female's 7 examples, age 32-67 year, the median age 46 years old.

Be divided into treatment group and matched group, treatment group 12 examples, male 9 examples, female's 3 examples, age 32-66 year, the median age 48 years old, course of disease 3-10, Median duration of symptoms 6 years, the aggravation emergency treatment of past 1 year and number of times 1-4 time of being in hospital.

Matched group 10 examples, male 6 examples, female's 4 examples, age 34-67 year, the median age 50 years old, course of disease 5-11, Median duration of symptoms 7 years, the aggravation emergency treatment of past 1 year and number of times 1-4 time of being in hospital.Before treatment, all patient's routine blood tests, hepatic and renal function are all normal.

Two, therapeutic scheme

Voluntary according to patient, be divided into treatment group and matched group, treatment group is administration after informed consent.Matched group: 12 examples give oral erythromycin 0.125mg, every day 3 times, ambroxol 30mg, every day 3 times, 2 of Asmetons, every day 3 times, 52 weeks courses for the treatment of.Treatment group 12 examples, use Chinese medicine preparation of the present invention, and side uses: Radix Platycodonis 12g, Semen Armeniacae Amarum 13g, Rhizoma Pinelliae Preparatum 11g, Bulbus Fritillariae Thunbergii 13g, Radix Scrophulariae 12g, Cortex Mori 12g, Radix Scutellariae 13g, Radix Cirsii Japonici 12g, Herba Cirsii 13g, Radix Stemonae 12g, Radix Glycyrrhizae 13g, Fructus Arctii 14g, Radix Rehmanniae 11g, Rhizoma Polygonati 12g, Fructus Corni 13g, Radix Salviae Miltiorrhizae 13g, Radix Paeoniae Alba 13g.Equal 52 weeks of the course for the treatment of.During treatment as occur acute exacerbation, the treatment such as give conventional antiinflammatory, eliminate the phlegm continues above-mentioned treatment simultaneously.In the 2nd week, the 8th week, the 26th week, the 52nd week, accept routine blood test, hepatic and renal function inspection, and record every 24h amount of coughing up phlegm of the 2nd week, the 8th week and get its average, record viewing duration emergency treatment and the number of times of being in hospital.

Three, statistical procedures

Measurement data is done t check in group, between group.

Result:

1, clinical efficacy

Table 1 shows that treatment group the 2nd week, the 8th week amount of expectoration after treatment obviously reduces before treating, and especially more obvious after 8 weeks in treatment, the equal < 0.001 of P value, has statistical significance.

Before and after table 1 treatment group patient treatment, amount of expectoration is improved relatively

Time	n	Amount of expectoration (ml/d)
			Before treatment	12	57.72±15.35
Latter the 2nd week for the treatment of	12	33.25±12.43*
			Latter the 8th week for the treatment of	12	18.74±7.56*

With the front relatively * P for the treatment of < 0.05

2. table 2 shows that matched group the 2nd week amount of expectoration after treatment has minimizing, but P value > 0.05, not statistically significant.And 8 weeks rear amounts of expectoration for the treatment of also have more obviously minimizing, P value < 0.05, has statistical significance.

Before and after table 2 matched group patient treatment, amount of expectoration is improved relatively

Time	n	Amount of expectoration (ml/d)
			Before treatment	10	56.82±16.75
Latter the 2nd week for the treatment of	10	46.23±13.23*
			Latter the 8th week for the treatment of	10	37.44±10.54*

With the front relatively * P for the treatment of < 0.05

3. table 3 shows treatment group before treatment and the comparison that improves difference and matched group of 2 weeks, 8 weeks amounts of expectoration after treatment, has notable difference, P value < 0.001.

Before and after table 3 liang group patient treatment, amount of expectoration is improved the comparison of difference

Two, emergency treatment, the number of times of being in hospital

In treatment group 12 example 52 weeks, without being in hospital, there are 2 examples because of heating emergency treatment each 1 time.In matched group 10 examples, there is 1 example to be in hospital 3 times because of spitting of blood repeatedly, have 2 examples because of heating, the amount of vomicaing showed increased respectively 1 time in hospital.

Three, untoward reaction

In treatment group, there is the slight gastrointestinal reaction of 1 example, but transference cure after a week.All the other all occur without obvious adverse reaction.

Discuss:

Bronchiectasis is bronchial chronic irreversibility pyogenic infection disease, often because resident micropopulation repeated infection and influencing each other of bronchial obstruction in air flue cause carrying out property of bronchus destruction, severe patient Complicated with Pulmonary cardiopathia, respiratory failure.This group studies show that the Chinese medicine preparation of continuous 52 weeks has good therapeutic effect to bronchiectasis, and patient's amount of expectoration is improved obviously, and the number of times of being in hospital reduces, and emergency treatment number of times reduces, and relatively has obvious curative effect with matched group.

Specific embodiment 1: Wang, man, 32 years old, main suit when in February, 2009 is medical: as a child must cross pertussis.The head of a family does not note.After growing up, expectoration is obvious, and position chanP is obvious, and majority is green stench thick sputum.But without hemoptysis phenomenon.Easy pulmonary infection, easy catching a cold, weak, body is thin, and liver-fire is vigorous, and buccal is crimson.Feel the pulse: dysfunction of the spleen in transportation, raw in phlegm-damp; Hyperactivity of fire caused by deficiency of YIN, Tianjin refining expectorant burns; Pathogenic fire derived from stagnation of liver-QI, strongly fragrant in phlegm-fire; Element body is not enough, being invaded by exogenous pathogen.External application or take medicine orally treatment by Chinese herbs, symptom slightly alleviates, but increases the weight of while meeting anxious state of mind.Use following Drug therapy:

Side uses: Radix Platycodonis 12g, Semen Armeniacae Amarum 13g, Rhizoma Pinelliae Preparatum 11g, Bulbus Fritillariae Thunbergii 13g, Radix Scrophulariae 12g, Cortex Mori 12g, Radix Scutellariae 13g, Radix Cirsii Japonici 12g, Herba Cirsii 13g, Radix Stemonae 12g, Radix Glycyrrhizae 13g, Fructus Arctii 14g, Radix Rehmanniae 11g, Rhizoma Polygonati 12g, Fructus Corni 13g, Radix Salviae Miltiorrhizae 13g, Radix Paeoniae Alba 13g.50 weeks courses for the treatment of.

Treat January, expectoration phenomenon obviously reduces, and position chanP obviously just has productive cough to go out.Liver-fire is calmed down, and face starts ruddy, uses we to continue one month, and expectoration phenomenon continues to reduce, and body weight gain suppresses bacillus pyocyaneus and is attached to respiratory mucosa.Suppress vascular smooth muscle cell proliferation and migration, protection blood vessel inner skin cell function, inflammation-inhibiting cell in the infiltration of blood vessel wall and the expression of inflammation-inhibiting cytokine and somatomedin; therefore have certain effect to suppressing pulmonary vascular reconstruct, may delay the process of Complicated with Pulmonary arterial hypertension, pulmonary heart disease.Take medicine 50 weeks, expectoration phenomenon disappears, and follows up a case by regular visits to 3 years without recurrence.

Specific embodiment 2: money, female, 41 years old, because spitting of blood is repeatedly in hospital 3 times, easy catching a cold, had heating, the amount of vomicaing showed increased and is in hospital, goes various big hospital to treat.Bed throughout the year.Patient recurrent cough, expectoration, spitting of blood, had a strong impact on patient's work capacity and quality of life.Patient belongs to the body of insufficiency of lung-QI, deficiency of lung-YIN or deficiency of both QI and YIN more.Insufficiency of lung-QI, declares respectful not normal persistent cough, and gas not cloth Jin Zejin is polymerized to expectorant; Deficiency of lung-YIN, lung loses to moisten supports the few expectorant of dry cough, body fluid deficiency hyperactivity of fire and network wound spitting of blood ".If disease further develops, or illness of child viscera affecting mother one and lung spleen be with sick, or the kidney usually involved in chronic disease and deficiency of both the lung and kidney all can make the symptom of coughing, spit, spitting blood increase the weight of.Because of lung, this is tender dirty again, and innate deficiency is subject to exopathogen invasion and attack further.Exopathogen is violated lung often can lure bronchiectasis acute attack into, wherein especially with wind heat, wind and cold, wind-dryness, violates lung the most common feeling the pulse: the empty loss of body, dysfunction of the spleen in transportation, and raw in phlegm-damp; Hyperactivity of fire caused by deficiency of YIN, Tianjin refining expectorant burns; Pathogenic fire derived from stagnation of liver-QI, strongly fragrant in phlegm-fire; Element body is not enough, being invaded by exogenous pathogen.Use following Drug therapy.

Side uses: Radix Platycodonis 14g, Semen Armeniacae Amarum 13g, Rhizoma Pinelliae Preparatum 11g, Bulbus Fritillariae Thunbergii 13g, Radix Scrophulariae 12g, Cortex Mori 12g, Radix Scutellariae 13g, Radix Cirsii Japonici 12g, Herba Cirsii 13g, Radix Stemonae 12g, Radix Glycyrrhizae 13g, Fructus Arctii 13g, Radix Rehmanniae 14g, Rhizoma Polygonati 14g, Fructus Corni 13g, Radix Salviae Miltiorrhizae 13g, Radix Paeoniae Alba 14g.52 weeks courses for the treatment of.

Treat January, expectoration phenomenon obviously reduces, and hemoptysis phenomenon is stopped.Position chanP obviously just has productive cough to go out.Liver-fire is calmed down, and face starts ruddy, uses we to continue one month, and expectoration phenomenon continues to reduce, body weight gain, and immunity improves, no longer easy to catch cold.Hemoptysis no longer occurs.Can be engaged in simple work.Do not need bed.Take medicine 50 weeks, expectoration phenomenon disappears, and health starts health, work, and also no longer expectoration of work.Follow up a case by regular visits to and without hemoptysis, be in hospital for 3 years.

Claims (10)

1. treat bronchiectasic Chinese medicine preparation for one kind, it is characterized in that, in described preparation, the parts by weight of various crude drug comprise: 10～20 parts of Radix Platycodoniss, 10～20 parts, Semen Armeniacae Amarum, 10～20 parts of Rhizoma Pinelliae Preparatum, 10～20 parts of Bulbus Fritillariae Thunbergii, 10～20 parts of Radix Scrophulariaes, 10～20 parts of Cortex Mori, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Cirsii Japonicis, 10～20 parts of Herba Cirsiis, 10～20 parts of the Radixs Stemonae, 10～20 parts, Radix Glycyrrhizae, 10～20 parts of Fructus Arctiis, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas.

2. treat according to claim 1 bronchiectasic Chinese medicine preparation, it is characterized in that, in described preparation, the parts by weight of various crude drug are: 10～15 parts of Radix Platycodoniss, 10～15 parts, Semen Armeniacae Amarum, 10～15 parts of Rhizoma Pinelliae Preparatum, 10～15 parts of Bulbus Fritillariae Thunbergii, 10～15 parts of Radix Scrophulariaes, 10～15 parts of Cortex Mori, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Cirsii Japonicis, 10～20 parts of Herba Cirsiis, 10～20 parts of the Radixs Stemonae, 10～20 parts, Radix Glycyrrhizae, 10～20 parts of Fructus Arctiis, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas.

3. treat according to claim 1 bronchiectasic Chinese medicine preparation, it is characterized in that, in described preparation, the parts by weight of various crude drug are: 10～20 parts of Radix Platycodoniss, 10～20 parts, Semen Armeniacae Amarum, 10～20 parts of Rhizoma Pinelliae Preparatum, 10～20 parts of Bulbus Fritillariae Thunbergii, 10～20 parts of Radix Scrophulariaes, 10～20 parts of Cortex Mori, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Cirsii Japonicis, 10～15 parts of Herba Cirsiis, 10～15 parts of the Radixs Stemonae, 10～15 parts, Radix Glycyrrhizae, 10～15 parts of Fructus Arctiis, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Rhizoma Polygonatis, 10～15 parts of Fructus Corni, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of the Radix Paeoniae Albas.

4. as described in any one in claim 1～3, treat a preparation method for bronchiectasic Chinese medicine preparation, it is characterized in that, the process for producing granula of described Chinese medicine preparation comprises the following steps:

A. described crude drug is put into pulverizer grinding and sieving,

B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;

C. get again the medicinal residues after above-mentioned ethanol extraction, add water heating and refluxing extraction 2 times;

D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying are dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.

5. treat according to claim 4 the preparation method of bronchiectasic Traditional Chinese medicine preparation capsule agent, it is characterized in that, in described step a, described crude drug is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves standby.

6. treat according to claim 4 the preparation method of bronchiectasic Traditional Chinese medicine preparation capsule agent, it is characterized in that, in described step b, particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing.

7. treat according to claim 4 the preparation method of bronchiectasic Traditional Chinese medicine preparation capsule agent, it is characterized in that, in described steps d, above-mentioned two kinds of extracting solution are merged, 1.38 filtrate when concentrating under reduced pressure relative density is 70 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.60, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.

One kind as any one in claim 1～3 state treatment bronchiectasic Chinese medicine preparation preparation method, it is characterized in that, the preparation process of the oral solutions of described Chinese medicine preparation is: all raw materials are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; Above-mentioned two kinds of extracting solution are merged, and it is concentrated that recovery ethanol is put into concentrator, adds dextrin and be in harmonious proportion, bottling.

9. preparation method according to claim 8, is characterized in that, above-mentioned steps reclaims after ethanol decompression and puts into concentrator when concentrated, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

10. according to treating bronchiectasic Chinese medicine preparation described in any one in claim 1～9, it is characterized in that, the dosage form of the bronchiectasic Chinese medicine preparation of described treatment is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plaster or cream.