CN103705802B - 一种治疗中耳炎的药物组合物及其应用 - Google Patents
一种治疗中耳炎的药物组合物及其应用 Download PDFInfo
- Publication number
- CN103705802B CN103705802B CN201410000826.8A CN201410000826A CN103705802B CN 103705802 B CN103705802 B CN 103705802B CN 201410000826 A CN201410000826 A CN 201410000826A CN 103705802 B CN103705802 B CN 103705802B
- Authority
- CN
- China
- Prior art keywords
- parts
- otitis media
- pharmaceutical composition
- treatment
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 21
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 19
- 206010033078 Otitis media Diseases 0.000 title claims abstract description 17
- 210000000582 semen Anatomy 0.000 claims abstract description 23
- 206010033081 Otitis media chronic Diseases 0.000 claims abstract description 15
- 201000010354 chronic purulent otitis media Diseases 0.000 claims abstract description 15
- 241000628997 Flos Species 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 10
- 239000008187 granular material Substances 0.000 claims description 9
- 238000009472 formulation Methods 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 2
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- 229960001699 ofloxacin Drugs 0.000 abstract description 6
- 201000010099 disease Diseases 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000000706 filtrate Substances 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 6
- 210000000959 ear middle Anatomy 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 229920001353 Dextrin Polymers 0.000 description 4
- 239000004375 Dextrin Substances 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 235000019425 dextrin Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 239000003221 ear drop Substances 0.000 description 3
- 229940047652 ear drops Drugs 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 2
- 244000192528 Chrysanthemum parthenium Species 0.000 description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- 241001278898 Glycyrrhiza inflata Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 208000033809 Suppuration Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000024035 chronic otitis media Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 235000008384 feverfew Nutrition 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000003454 tympanic membrane Anatomy 0.000 description 2
- 241000092665 Atractylodes macrocephala Species 0.000 description 1
- 241000304886 Bacilli Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000131317 Capitulum Species 0.000 description 1
- 235000009604 Chrysanthemum X morifolium Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 244000077995 Coix lacryma jobi Species 0.000 description 1
- 235000007354 Coix lacryma jobi Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- 241001135871 Gentiana scabra Species 0.000 description 1
- 241001071804 Gentianaceae Species 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000878128 Malleus Species 0.000 description 1
- 208000010315 Mastoiditis Diseases 0.000 description 1
- 235000012629 Mentha aquatica Nutrition 0.000 description 1
- 208000025690 Otorhinolaryngologic disease Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 240000000275 Persicaria hydropiper Species 0.000 description 1
- 235000017337 Persicaria hydropiper Nutrition 0.000 description 1
- 241000219050 Polygonaceae Species 0.000 description 1
- 235000004442 Polygonum persicaria Nutrition 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000057271 Prunus humilis Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 201000002014 Suppurative Otitis Media Diseases 0.000 description 1
- 241000256856 Vespidae Species 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 244000144987 brood Species 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000012074 hearing test Methods 0.000 description 1
- 208000022760 infectious otitis media Diseases 0.000 description 1
- 230000003447 ipsilateral effect Effects 0.000 description 1
- 210000002331 malleus Anatomy 0.000 description 1
- 210000001664 manubrium Anatomy 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 201000004478 non-suppurative otitis media Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 208000025301 tympanitis Diseases 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Abstract
Description
Claims (5)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410000826.8A CN103705802B (zh) | 2014-01-02 | 2014-01-02 | 一种治疗中耳炎的药物组合物及其应用 |
CN201510743767.8A CN105194444A (zh) | 2014-01-02 | 2014-01-02 | 一种制备治疗中耳炎的药物组合物胶囊制剂的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410000826.8A CN103705802B (zh) | 2014-01-02 | 2014-01-02 | 一种治疗中耳炎的药物组合物及其应用 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510743767.8A Division CN105194444A (zh) | 2014-01-02 | 2014-01-02 | 一种制备治疗中耳炎的药物组合物胶囊制剂的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103705802A CN103705802A (zh) | 2014-04-09 |
CN103705802B true CN103705802B (zh) | 2015-09-30 |
Family
ID=50399389
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510743767.8A Withdrawn CN105194444A (zh) | 2014-01-02 | 2014-01-02 | 一种制备治疗中耳炎的药物组合物胶囊制剂的方法 |
CN201410000826.8A Expired - Fee Related CN103705802B (zh) | 2014-01-02 | 2014-01-02 | 一种治疗中耳炎的药物组合物及其应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510743767.8A Withdrawn CN105194444A (zh) | 2014-01-02 | 2014-01-02 | 一种制备治疗中耳炎的药物组合物胶囊制剂的方法 |
Country Status (1)
Country | Link |
---|---|
CN (2) | CN105194444A (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104840732A (zh) * | 2015-06-02 | 2015-08-19 | 岳兵兵 | 一种治疗中耳炎的中药剂及制法 |
CN105169353A (zh) * | 2015-10-23 | 2015-12-23 | 王景明 | 一种治疗分泌性中耳炎的中药 |
CN105596599A (zh) * | 2016-01-25 | 2016-05-25 | 济南星懿医药技术有限公司 | 治疗中耳炎的药物组合物及其制备方法 |
CN105878507A (zh) * | 2016-05-19 | 2016-08-24 | 张湛曼 | 一种治疗中耳炎的中药组合物凝胶及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1320433A (zh) * | 2000-04-25 | 2001-11-07 | 张占军 | 一种治疗鼻炎、鼻窦炎散剂的制作方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1098302A (zh) * | 1993-08-02 | 1995-02-08 | 王敬忠 | 治疗中耳炎的中药制剂 |
CN101468151A (zh) * | 2007-12-24 | 2009-07-01 | 王月 | 一种治疗中耳炎的中药制剂 |
-
2014
- 2014-01-02 CN CN201510743767.8A patent/CN105194444A/zh not_active Withdrawn
- 2014-01-02 CN CN201410000826.8A patent/CN103705802B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1320433A (zh) * | 2000-04-25 | 2001-11-07 | 张占军 | 一种治疗鼻炎、鼻窦炎散剂的制作方法 |
Non-Patent Citations (2)
Title |
---|
中医治疗慢性化脓性中耳炎概况;赵虹;《云南中医杂志》;19911231;第12卷(第1期);第43页 * |
中医辨证论治及中西医结合治疗慢性化脓性中耳炎;罗克强;《中国中西医结合耳鼻咽喉科杂志》;20041231;第12卷(第6期);第306页 * |
Also Published As
Publication number | Publication date |
---|---|
CN105194444A (zh) | 2015-12-30 |
CN103705802A (zh) | 2014-04-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103705802B (zh) | 一种治疗中耳炎的药物组合物及其应用 | |
CN103961422A (zh) | 用于治疗鼻炎的组合药物 | |
CN101537141A (zh) | 一种清热解毒、疏风消肿、利咽通窍的药物组合 | |
CN104173546A (zh) | 治疗鼻炎的中药水 | |
CN103989906A (zh) | 一种治疗甲状腺癌、淋巴癌的药物组合物 | |
CN1320895C (zh) | 治疗鼻炎的鼻腔给药的中药制剂 | |
CN102274353B (zh) | 治疗溃疡的中药制剂 | |
CN104491806A (zh) | 一种治疗过敏性鼻炎的外用中药药物 | |
CN103127465B (zh) | 一种治疗乳腺增生中药 | |
CN108066588B (zh) | 一种治疗鼻炎的中药组合物、外用贴剂及其制备方法 | |
CN105327103A (zh) | 一种治疗鼻炎、鼻窦炎的药物组合物及其制备方法 | |
CN104383475A (zh) | 一种用于治疗冻疮的中药制剂 | |
CN105412766A (zh) | 一种治疗慢性腹泻的药物组合物 | |
CN105125682A (zh) | 一种用于治疗面瘫的药物制剂 | |
CN105396105A (zh) | 一种制备防治小儿反复感冒的中药组合物的方法 | |
CN105395633A (zh) | 一种应用于化脓性中耳炎的外用涂剂及制备方法 | |
CN105362999A (zh) | 一种防治小儿反复感冒的中药制剂及其制备方法 | |
CN104840823A (zh) | 一种治疗中耳炎的中药制剂及制法 | |
CN104840822A (zh) | 治疗中耳炎的中药组合物 | |
CN104257875A (zh) | 用于妇女急性乳腺炎护理的外用中药组合物 | |
CN104587035A (zh) | 一种治疗口腔溃疡的药物组合物及其制备方法 | |
CN103316218B (zh) | 一种治疗黄水疮的外用药物及应用 | |
CN104825884A (zh) | 一种治疗鼻窦炎的中药方剂 | |
CN104162046A (zh) | 一种用于治疗幼女性阴道炎的中药 | |
CN103908617B (zh) | 一种治疗复发性口腔溃疡的药液 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Xu Xiaoli Inventor before: Liu Xuejian |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LIU XUEJIAN TO: XU XIAOLI |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information |
Inventor after: Xu Xiaoli Inventor after: Yang Peizhen Inventor before: Xu Xiaoli |
|
COR | Change of bibliographic data | ||
CB03 | Change of inventor or designer information |
Inventor after: Xu Xiaoli Inventor after: Yang Peizhen Inventor after: Hu Yanxia Inventor before: Xu Xiaoli Inventor before: Yang Peizhen |
|
TR01 | Transfer of patent right |
Effective date of registration: 20170526 Address after: 226000, 9 Jiangsu Road, Binjiang fine chemical industry zone, Nantong, Jiangsu, Qidong Patentee after: Nantong Finc Pharmaceutical Chemical Co., Ltd. Address before: 266200 Jimo, Qingdao, the Yellow River, No. two, No. Road, building 25, building 182 Patentee before: Wang Xueyan |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150930 Termination date: 20190102 |