CN103702991A - 用作jak抑制剂的吡啶-2(1h)-酮衍生物 - Google Patents

用作jak抑制剂的吡啶-2(1h)-酮衍生物 Download PDF

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Publication number
CN103702991A
CN103702991A CN201280036953.2A CN201280036953A CN103702991A CN 103702991 A CN103702991 A CN 103702991A CN 201280036953 A CN201280036953 A CN 201280036953A CN 103702991 A CN103702991 A CN 103702991A
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group
branched
cycloalkyl
alkyl
hydrogen atom
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P·R·伊斯特伍德
J·巴赫塔纳
L·M·帕格斯圣塔卡纳
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Almirall SA
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280036953.2A 2011-08-01 2012-07-23 用作jak抑制剂的吡啶-2(1h)-酮衍生物 Pending CN103702991A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11382263A EP2554544A1 (en) 2011-08-01 2011-08-01 Pyridin-2(1h)-one derivatives as jak inhibitors
EP11382263.9 2011-08-01
US201161556948P 2011-11-08 2011-11-08
US61/556,948 2011-11-08
PCT/EP2012/064426 WO2013017461A1 (en) 2011-08-01 2012-07-23 Pyridin-2(1h)-one derivatives as jak inhibitors

Publications (1)

Publication Number Publication Date
CN103702991A true CN103702991A (zh) 2014-04-02

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CN201280036953.2A Pending CN103702991A (zh) 2011-08-01 2012-07-23 用作jak抑制剂的吡啶-2(1h)-酮衍生物

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Country Link
US (1) US9034311B2 (enExample)
EP (2) EP2554544A1 (enExample)
JP (1) JP2014521673A (enExample)
KR (1) KR20140044865A (enExample)
CN (1) CN103702991A (enExample)
AR (1) AR087355A1 (enExample)
AU (1) AU2012292276A1 (enExample)
BR (1) BR112014002245A2 (enExample)
CA (1) CA2839805A1 (enExample)
CL (1) CL2014000203A1 (enExample)
CO (1) CO6852079A2 (enExample)
CR (1) CR20140031A (enExample)
EA (1) EA201400182A1 (enExample)
GT (1) GT201400017A (enExample)
MX (1) MX2014000635A (enExample)
PE (1) PE20141409A1 (enExample)
PH (1) PH12014500103A1 (enExample)
UY (1) UY34212A (enExample)
WO (1) WO2013017461A1 (enExample)
ZA (1) ZA201309187B (enExample)

Cited By (1)

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CN107735091A (zh) * 2015-06-22 2018-02-23 爱维斯健有限公司 包含伊马替尼作为活性成分的用于预防和治疗干眼病的药物组合物

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EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
LT3177612T (lt) 2014-08-04 2022-06-10 Nuevolution A/S Pirimidino dariniai, pakeisti pasirinktinai kondensuotu heterociklilu, tinkami uždegiminių, metabolinių, onkologinių ir autoimuninių ligų gydymui
US10059689B2 (en) * 2014-10-14 2018-08-28 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
EA202092442A3 (ru) 2016-06-07 2021-08-31 Джакобио Фармасьютикалс Ко., Лтд. Новые гетероциклические производные, применимые в качестве ингибиторов shp2
AU2017378398B2 (en) * 2016-12-14 2023-02-02 Bt Bidco, Inc. Treatment of a disease of the gastrointestinal tract with a JAK inhibitor and devices
AU2018239542C1 (en) 2017-03-23 2021-02-11 Jacobio Pharmaceuticals Co., Ltd. Novel heterocyclic derivatives useful as SHP2 inhibitors
CA3076276C (en) * 2017-09-21 2022-10-25 Beijing Scitech-Mq Pharmaceuticals Limited 2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof
KR102808367B1 (ko) 2017-11-06 2025-05-14 브리스톨-마이어스 스큅 컴퍼니 Hpk1 억제제로서 유용한 이소푸라논 화합물
CN110372664A (zh) * 2018-04-13 2019-10-25 华东理工大学 选择性jak2抑制剂及其应用
US12030875B2 (en) 2018-09-07 2024-07-09 PIC Therapeutics, Inc. EIF4E inhibitors and uses thereof
US20210393623A1 (en) 2018-09-26 2021-12-23 Jacobio Pharmaceuticals Co., Ltd. Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
US20220372135A1 (en) 2019-09-27 2022-11-24 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
MX2022007265A (es) 2019-12-20 2022-09-09 Nuevolution As Compuestos activos frente a receptores nucleares.
TWI872177B (zh) 2019-12-20 2025-02-11 丹麥商紐韋盧森公司 對核受體具有活性之化合物
AU2021230289A1 (en) 2020-03-03 2022-09-29 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
US11780843B2 (en) 2020-03-31 2023-10-10 Nuevolution A/S Compounds active towards nuclear receptors
US11613532B2 (en) 2020-03-31 2023-03-28 Nuevolution A/S Compounds active towards nuclear receptors
CA3177830A1 (en) 2020-05-13 2021-11-18 Maria BECONI Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
CN118019739A (zh) 2021-08-25 2024-05-10 皮克医疗公司 Eif4e抑制剂及其用途
JP2024534127A (ja) 2021-08-25 2024-09-18 ピク セラピューティクス， インコーポレイテッド ｅＩＦ４Ｅ阻害剤及びその使用
KR102503968B1 (ko) 2022-09-22 2023-02-28 이진석 실꼬리 절단장치 및 그를 구비하는 양말 편직기

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WO2010085684A1 (en) * 2009-01-23 2010-07-29 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
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