CN103688151B - 用于检测和定量组织中的靶分子的方法 - Google Patents

用于检测和定量组织中的靶分子的方法 Download PDF

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CN103688151B
CN103688151B CN201280026907.4A CN201280026907A CN103688151B CN 103688151 B CN103688151 B CN 103688151B CN 201280026907 A CN201280026907 A CN 201280026907A CN 103688151 B CN103688151 B CN 103688151B
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tissue
molecule
tissue homogenate
signal
standard
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CN103688151A (zh
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乔纳森·斯陶贝尔
大卫·博内尔
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Imabiotech
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2866—Grinding or homogeneising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N2001/2893—Preparing calibration standards

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
CN201280026907.4A 2011-05-31 2012-05-29 用于检测和定量组织中的靶分子的方法 Active CN103688151B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1154731A FR2976076B1 (fr) 2011-05-31 2011-05-31 Procede de detection et de quantification d'une molecule cible dans un tissu
FR1154731 2011-05-31
PCT/FR2012/051205 WO2012164221A1 (fr) 2011-05-31 2012-05-29 Procede de detection et de quantification d'une molecule cible dans un tissu

Publications (2)

Publication Number Publication Date
CN103688151A CN103688151A (zh) 2014-03-26
CN103688151B true CN103688151B (zh) 2016-05-18

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US (1) US10132796B2 (https=)
EP (1) EP2715310B1 (https=)
JP (1) JP6170911B2 (https=)
KR (1) KR102004350B1 (https=)
CN (1) CN103688151B (https=)
AU (1) AU2012264458B2 (https=)
CA (1) CA2837153C (https=)
DK (1) DK2715310T3 (https=)
ES (1) ES2922478T3 (https=)
FR (1) FR2976076B1 (https=)
IN (1) IN2013MN02451A (https=)
WO (1) WO2012164221A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11959838B2 (en) 2015-11-06 2024-04-16 Ventana Medical Systems, Inc. Representative diagnostics

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ES2693037T3 (es) * 2013-02-25 2018-12-07 Imabiotech Método para evaluar la acción selectiva de una molécula de interés por un tejido
CN103336128A (zh) * 2013-06-08 2013-10-02 天津药物研究院 一种检测小分子多肽类药物组织分布的方法
KR101996666B1 (ko) * 2016-05-02 2019-07-04 주식회사 엘지화학 정량 분석 방법
JP7010373B2 (ja) 2018-05-30 2022-01-26 株式会社島津製作所 スペクトルデータ処理装置及び分析装置
CN115836210A (zh) * 2020-02-27 2023-03-21 Lsk 技术公司 使用光学反应表征来自感兴趣区域的化验的系统和方法
WO2021175842A1 (en) 2020-03-02 2021-09-10 Universiteit Maastricht Quality control standards for mass spectrometry imaging
CN115326915A (zh) * 2022-08-01 2022-11-11 中央民族大学 一种植物组织微阵列maldi-msi高通量分析方法

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AU2003272924B2 (en) * 2002-10-04 2008-05-15 Protosera Inc. Plate for mass spectrometry, process for preparing the same and use thereof
US20040096907A1 (en) * 2002-11-06 2004-05-20 Bernd Bohrmann Quantification of beta amyloid
JP2005181011A (ja) * 2003-12-17 2005-07-07 Yoshio Yamauchi タンパク質解析方法
JP4547173B2 (ja) 2004-03-17 2010-09-22 シスメックス株式会社 糖尿病診療支援システム
WO2007000669A2 (en) 2005-06-07 2007-01-04 Centre National De La Recherche Scientifique (Cnrs) Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections
EP2163900A1 (en) 2008-09-04 2010-03-17 Commissariat A L'energie Atomique New method of imaging by mass spectrometry and new mass tag associated trityl derivatives
WO2010041459A1 (ja) * 2008-10-08 2010-04-15 積水メディカル株式会社 薬物代謝物の定量分析方法及び分析装置
WO2011073740A1 (en) 2009-12-15 2011-06-23 Centre National De La Recherche Scientifique (Cnrs) Matrices for mass spectrometry imaging
FR2973112B1 (fr) 2011-03-21 2018-05-25 Imabiotech Procede de detection et de quantification d'une molecule cible dans un echantillon
EP2767832A1 (en) 2013-02-18 2014-08-20 Imabiotech Photo or chemolabile conjugates for molecules detection
ES2693037T3 (es) 2013-02-25 2018-12-07 Imabiotech Método para evaluar la acción selectiva de una molécula de interés por un tejido

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Elemental imaging mass spectrometry of thin sections of tissues and analysis of brain proteins in gels by laser ablation inductively coupled plasma mass spectrometry;J.Sa.Becker 等;《phys. stat. sol.(c)》;20070509;第4卷(第6期);第1777页第5-9行，第1777-1779页"2 Experimental"，第1779页"3.1 Reproducibility studies of imaging mass spectrometry by LA-ICP-MS"，第1780页第12-14行，图4 *
Qualitative and quantitative analysis of low molecular weight compounds by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry using ionic liquid matrices;Masoud Zabet-Moghaddam 等;《RAPID COMMUNICATIONS IN MASS SPECTROMETRY》;20041231;第18卷(第2期);141-148 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11959838B2 (en) 2015-11-06 2024-04-16 Ventana Medical Systems, Inc. Representative diagnostics

Also Published As

Publication number Publication date
CA2837153A1 (fr) 2012-12-06
CN103688151A (zh) 2014-03-26
WO2012164221A1 (fr) 2012-12-06
FR2976076A1 (fr) 2012-12-07
JP2014520259A (ja) 2014-08-21
EP2715310A1 (fr) 2014-04-09
US10132796B2 (en) 2018-11-20
AU2012264458A1 (en) 2014-01-09
AU2012264458B2 (en) 2015-09-24
CA2837153C (fr) 2019-06-25
KR102004350B1 (ko) 2019-07-26
IN2013MN02451A (https=) 2015-04-17
JP6170911B2 (ja) 2017-07-26
ES2922478T3 (es) 2022-09-15
KR20140051187A (ko) 2014-04-30
DK2715310T3 (da) 2022-07-25
EP2715310B1 (fr) 2022-04-27
US20140106391A1 (en) 2014-04-17
FR2976076B1 (fr) 2015-02-27

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