CN103656276B

CN103656276B - Medicine for the treatment of renal failure and preparation method thereof

Info

Publication number: CN103656276B
Application number: CN201310609736.4A
Authority: CN
Inventors: 刘明杰; 孟琴
Original assignee: WEIFANG INSTITUTE OF MODERN RHEUMATOLOGY
Current assignee: WEIFANG INSTITUTE OF MODERN RHEUMATOLOGY
Priority date: 2013-11-27
Filing date: 2013-11-27
Publication date: 2015-08-26
Anticipated expiration: 2033-11-27
Also published as: CN103656276A; WO2015078357A1; CN104800626A; CN104758699A

Abstract

The present invention relates to a kind of Chinese medicine and preparation method thereof, especially a kind of medicine for the treatment of renal failure and preparation method thereof.The present invention with bamboo, Os Draconis, Radix Angelicae Pubescentis, Pericarpium Citri Reticulatae, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, climbing entada seed for principal agent thing, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, Radix Glycyrrhizae, Fructus Mume, Radix Pseudostellariae, Flos puerariae lobatae, Folium Nelumbinis, Fructus Citri Sarcodactylis, Herba Leonuri, Herba Andrographis, Fructus Gardeniae, Caulis Bambusae In Taenia, Fructus Chaenomelis, Radix Rehmanniae Preparata are accessory drugs, from the principle that Kidney Theory in TCM is the foundation of acquired constitution, the main water transport of kidney, support the gas of kidney, row kidney water, Coryza Treated by Syndrome Differentiation renal failure, side effect is little, curative effect is high, can alleviate patient's slight illness.

Description

Medicine for the treatment of renal failure and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine and preparation method thereof, especially a kind of medicine for the treatment of renal failure and preparation method thereof.

Background technology

Renal failure and nephrotic syndrome, can be caused by Different types of etiopathogenises, increases with glomerular basement membrane permeability, shows as one group of clinical syndrome that High-grade Proteinuria, hypoproteinemia, treating serious edema caused, hyperlipemia and other metabolism disorders are feature.

Nephrotic syndrome is divided into constitutional, Secondary cases and heritability three major types, and primary nephrotic syndrome belongs to primary glomerulopathy, and having multiple histological type to form is a kind of common clinical disease.Current treatment means is more single.Available drugs is also more single.And by a big chunk patient.After treatment, recurrence is very high with probability repeatedly.The misery caused to patient is very large.Existing Therapy of Nephrotic Syndrome means are single, and medicine toxic and side effects used is large, be now badly in need of that a kind of side effect is little, curative effect obviously and cost can alleviate the medicine of patient's slight illness relatively less.

Summary of the invention

The object of this invention is to provide that a kind of side effect is little, curative effect is high, the medicine that can alleviate the treatment renal failure of patient's slight illness and preparation method thereof.

The medicine for the treatment of renal failure of the present invention comprises the medicine of heavily treating renal failure as follows, it is characterized in that the composition comprising following parts by weight: bamboo 15-55, Os Draconis 15-25, Radix Angelicae Pubescentis 15-25, Pericarpium Citri Reticulatae 15-25, Herba Hedyotidis Diffusae 15-45, Herb Gynostemmae Pentaphylli 15-25, climbing entada seed 15-35, Herba Lophatheri 5-15, Radix Glycyrrhizae 25-75, Fructus Mume 5-15, Radix Pseudostellariae 5-35, Flos puerariae lobatae 5-15, Folium Nelumbinis 5-15, Fructus Citri Sarcodactylis 5-15, Herba Leonuri 5-15, Herba Andrographis 5-15, Fructus Gardeniae 5-15, Caulis Bambusae In Taenia 15-55, Fructus Chaenomelis 5-15, Radix Rehmanniae Preparata 15-35.

As a further improvement on the present invention, the ratio of weight and number of above-mentioned each composition is as follows: bamboo 35-55, Os Draconis 15-25, Radix Angelicae Pubescentis 15-25, Pericarpium Citri Reticulatae 15-25, Herba Hedyotidis Diffusae 35-45, Herb Gynostemmae Pentaphylli 15-25, climbing entada seed 15-25, Herba Lophatheri 5-15, Radix Glycyrrhizae 55-75, Fructus Mume 5-15, Radix Pseudostellariae 5-15, Flos puerariae lobatae 5-15, Folium Nelumbinis 5-15, Fructus Citri Sarcodactylis 5-15, Herba Leonuri 5-15, Herba Andrographis 5-15, Fructus Gardeniae 5-15, Caulis Bambusae In Taenia 35-55, Fructus Chaenomelis 5-15, Radix Rehmanniae Preparata 30-35.

The preparation method of the medicine of above-mentioned treatment renal failure, comprises the following steps that order is carried out:

A) bamboo, Radix Glycyrrhizae, Fructus Mume, Folium Nelumbinis, Fructus Citri Sarcodactylis, Radix Angelicae Pubescentis, Herba Leonuri, Herba Andrographis, Fructus Gardeniae, Caulis Bambusae In Taenia, Radix Rehmanniae Preparata are put into according to the above ratio in the warm water of 20-30 DEG C and soak 4-6 hour, the parts by weight of warm water are 800-1200; Then drop into after marmite is heated to seethe with excitement and decoct 10-20 minute, then add Herba Lophatheri, Flos puerariae lobatae, Pericarpium Citri Reticulatae, turn little fire and keep a fluidized state to continue to decoct 20-30 minute, filtering medicinal residues after natural cooling, obtain a medicinal liquid; Os Draconis, Radix Pseudostellariae, Fructus Chaenomelis, climbing entada seed are dropped into respectively in the warm water of warm water 100-200 weight portion and soak 4-6 hour, the temperature of warm water is 20-30 DEG C, then Os Draconis, Radix Pseudostellariae, Fructus Chaenomelis, climbing entada seed and immersion liquid thereof are dropped into marmite together, be heated to water boiling and continue decoction 50 minutes, filtering medicinal residues, obtain No. two medicinal liquids after natural cooling.

B) by above gained medicinal liquid, No. two medicinal liquid mix homogeneously, enter after marmite is heated to boiling and add Herba Hedyotidis Diffusae and Herb Gynostemmae Pentaphylli, keep fluidized state to continue decoction 35 minutes, after natural cooling, obtain the medicine of described treatment renal failure.

Bamboo has another name called that Concretio silicea Bambusae seu schizostachyi, Concretio silicea Bambusae seu schizostachyi, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle etc. belong to mycota, Ascomycotina, gang pyrenomycetes, Hypocreales, Hypocreaceae, Concretio silicea Bambusae seu schizostachyi belong to fungus.Be born in the bamboo grove decaying or be about to decay, medicinal part is the Stroma of Fungus Zhuhuang more.There is relieving cough and reducing sputum, regulating QI to relieve pain, relieving convulsion effect.

Os Draconis be ancient times mammal as if the fossil of skeleton of class, rhinoceros class, Hippocampal cortex etc.Main function: tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.

Radix Angelicae Pubescentis is the dry root of samphire Angelica pubescens, pungent, bitter, and tepor, for anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache.Modern study, Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation; Inhibitory action is had to platelet aggregation; And it is not have hypotensive effect, but lasting; Contained bergapten, xanthotoxin etc. have photosensitive and antitumor action.

Pericarpium Citri Reticulatae, another name: Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, extensively Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis.For the mature peel of rutaceae orange and variety thereof.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Herba Hedyotidis Diffusae, formal name used at school: Hedyotis diffusa is the plant of Rubiaceae cerastium, the traditional Chinese medical science conventional treatment dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom etc.

Herb Gynostemmae Pentaphylli is the herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli.Also known as paradise is careless, Gospel is careless, Chao Rencan, Herb Gynostemmae Pentaphylli, Herba Gynostemmatis, Herba Gynostemmatis, Pentapanax and gynostemma pentaphyllum makino etc.Bitter in the mouth; Micro-sweet; Cool in nature.Cure mainly: body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.

Climbing entada seed is the seed of tropical plants Caulis Bauhihiae Championii.Property flat, sweet in the mouth, puckery.Cure mainly: insomnia and dreamful sleep, children's's scaring, obstinate rheumatism etc.

Herba Lophatheri is herbaceos perennial, high 40-90cm.Root stock tubbiness, hard.Another name is broken GUCAO, Gallus jabouillei rice is careless, bamboo grass.Root is medicinal, has refrigerant, antipyretic, diuresis and the effect of hastening parturition.

Radix Glycyrrhizae, prescription name: Radix Glycyrrhizae, SHENGCAO, Radix Glycyrrhizae, Radix Glycyrrhizae Preparata, Radix Glycyrrhizae Preparata, the careless tip, Radix Glycyrrhizae uralensis, the SHENGCAO tip etc.For dicotyledon pulse family Leguminosae Radix Glycyrrhizae GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. G.inflataBat., or the root and rhizome of Glycyrrhiza glabra L. G.glabraL.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.

Fructus Mume, another name dark plum, yellow son, conjunction Chinese prunus mume (sieb.) sieb.et zucc., dry branch prunus mume (sieb.) sieb.et zucc., be the almost ripe fruit of rosaceae plant deciduous tree prunus mume (sieb.) sieb.et zucc. Prunus mume, smoke form through pyrotechnics.According to modern study, many and less containing sodium containing potassium in Fructus Mume, therefore, need long-term taking to arrange potassium diuretic person and should eat it; Containing multiple organic acid in Fructus Armeniacae Mume, be improved the effect of liver function, therefore hepatopath should eat it.

Radix Pseudostellariae, has another name called Radix Ginseng, Tong Can.For the tuber of Caryophyllaceae herbaceos perennial pseudostellaria heterophylla.Sweet, micro-hardship, tepor.Qi-restoratives medicine, Qi-tonifying drug.Cure mainly: mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid.

Flos puerariae lobatae is the dried floral of leguminous plant Pueraria lobota Puerarialobata (Willd.) Ohwi.There is the effect of heat clearing away, removing toxic substances, hepatoprotective, skin care, the kidney invigorating.

Folium Nelumbinis, prescription name: Folium Nelumbinis, Folium Nelumbinis, new lotus leaf, dry Folium Nelumbinis, burnt FOLIUM NELUMBINIS etc.It is the dried leaves of nymphaeaceae plant lotus.There is summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, effect of dissipating blood stasis hemostasis.

Fructus Citri Sarcodactylis, has another name called: nine pawl wood, the five fingers Fructus Citri tangerinae, Fructus Citri Sarcodactylis, is the fruit of rutaceae Fructus Citri Sarcodactylis Citrusmedica L.var.sarcodactylis Swingle.Pungent, bitter, sweet, warm, nontoxic; Enter liver, spleen, stomach three warp, have activating QI to eliminate phlegm, preventing or arresting vomiting relieving distension, the liver soothing and the spleen invigorating, the more kinds of medicinal function of stomach function regulating.

Herba Leonuri is the herb of labiate Herba Leonuri.The root of Herba Leonuri, stem, flower, leaf, reality, and be all used as medicine, can with using.Bitter, pungent, be slightly cold.Return liver, pericardium channel.Cure mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.

Herba Andrographis is herb or the leaf of acanthaceous plant Herba Andrographis (Andrographis paniculata (Burm.f.) Nees).Have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.There are heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.

Fructus Gardeniae, another name Yellow Fructus Gardeniae, Fructus Gardeniae, white toad are the fruits of Maguireothamnus speciosus Fructus Gardeniae.At present, the fruit of Fructus Gardeniae is Chinese medicine, and the l belonging to Ministry of Public Health promulgation criticizes medicine-food two-purpose resource, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.The diseases such as treatment icterohepatitis, bruise, hypertension, diabetes are usually used at tcm clinical practice.

Caulis Bambusae In Taenia, have another name called bamboo skin, QINGZHU is eaten, and phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle skin is eaten.It is the dry intermediate layer of stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.Containing lignin, cellulose.Cold nature, sweet in the mouth.The traditional Chinese medical science is usually used in for cough due to lung-heat, and expectorant is yellow and febrile disease is irritated, palpitation with fear.

Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria (Chaenomeles speciosa (Sweet) Nakai.).Nature and flavor: acid, temperature.Return liver, spleen channel.Cure mainly: suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.

Radix Rehmanniae Preparata, is the tuber of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmannia glutinosa), has another name called Radix Rehmanniae Preparata or throw oneself on the ground, forming through Processing methods.There is YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, diseases such as also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, quench one's thirst.

The medicine for the treatment of renal failure of the present invention, with bamboo, Os Draconis, Radix Angelicae Pubescentis, Pericarpium Citri Reticulatae, Herba Hedyotidis Diffusae, Herb Gynostemmae Pentaphylli, climbing entada seed for principal agent thing, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, Radix Glycyrrhizae, Fructus Mume, Radix Pseudostellariae, Flos puerariae lobatae, Folium Nelumbinis, Fructus Citri Sarcodactylis, Herba Leonuri, Herba Andrographis, Fructus Gardeniae, Caulis Bambusae In Taenia, Fructus Chaenomelis, Radix Rehmanniae Preparata are accessory drugs, from the principle that Kidney Theory in TCM is the foundation of acquired constitution, the main water transport of kidney, support the gas of kidney, row kidney water, Coryza Treated by Syndrome Differentiation renal failure, side effect is little, curative effect is high, can alleviate patient's slight illness.

Detailed description of the invention

Embodiment 1:

Standby medicine, the composition preparation method preparing following parts by weight is as follows: bamboo 15-55, Os Draconis 15-25, Radix Angelicae Pubescentis 15-25, Pericarpium Citri Reticulatae 15-25, Herba Hedyotidis Diffusae 15-45, Herb Gynostemmae Pentaphylli 15-25, climbing entada seed 15-35, Herba Lophatheri 5-15, Radix Glycyrrhizae 25-75, Fructus Mume 5-15, Radix Pseudostellariae 5-35, Flos puerariae lobatae 5-15, Folium Nelumbinis 5-15, Fructus Citri Sarcodactylis 5-15, Herba Leonuri 5-15, Herba Andrographis 5-15, Fructus Gardeniae 5-15, Caulis Bambusae In Taenia 15-55, Fructus Chaenomelis 5-15, Radix Rehmanniae Preparata 15-35.Above-mentioned concrete component content can adjust in above-mentioned scope according to the feature and raw-material source adapting to disease.

Instructions of taking is as follows: the medicine of above-mentioned treatment renal failure being divided into every 50 grams is portion, and take for three times every day, oral each portion, every 15 days is a course for the treatment of.

Patient Mrs Wang, 31 years old.Whole individual spirit is tired standby, and with a haggard face, emaciated physique, health is very poor.Result of laboratory test report show: serum creatinine 716 μm of ol/L, urine protein ++, blood uric acid 502.7umol/L, blood urea nitrogen 28.2mmol/L.B ultrasonic shows: two kidneys atrophy of patient, left kidney 7.5CM, right kidney 7.9CM.Comprehensive indices diagnostic result is: uremia's middle and advanced stage, two renal atrophy, hyperuricemia.According to kidneys of patients Index for examination, the patient renal extent of damage is judged, after adopting the Drug therapy one month of the present embodiment, its spirit foot, complexion might as well, walk all energetically, appetite increases, and sleep also normal, blood test creatinine has dropped to 324umol/L, blood uric acid drops to 436 micromoles, and blood urea nitrogen drops to 18.5.After second month, 85umol/L has fallen again in creatinine, and 5mmol/L has fallen in blood urea nitrogen.CO2 combining power, CO2 CP and blood uric acid all reach normal index, and after the 3rd month, majority parameters trend is in normally.Present stable disease.Physical condition is clearly better, and can do farm work.

Embodiment 2:

Standby medicine, prepares the composition of following parts by weight: bamboo 35-55, Os Draconis 15-25, Radix Angelicae Pubescentis 15-25, Pericarpium Citri Reticulatae 15-25, Herba Hedyotidis Diffusae 35-45, Herb Gynostemmae Pentaphylli 15-25, climbing entada seed 15-25, Herba Lophatheri 5-15, Radix Glycyrrhizae 55-75, Fructus Mume 5-15, Radix Pseudostellariae 5-15, Flos puerariae lobatae 5-15, Folium Nelumbinis 5-15, Fructus Citri Sarcodactylis 5-15, Herba Leonuri 5-15, Herba Andrographis 5-15, Fructus Gardeniae 5-15, Caulis Bambusae In Taenia 35-55, Fructus Chaenomelis 5-15, Radix Rehmanniae Preparata 30-35.Above-mentioned concrete component content can adjust in above-mentioned scope according to the feature and raw-material source adapting to disease.

Preparation method and instructions of taking are with embodiment 1.

Patient marquis so-and-so, man, 34 years old.Over 5 years there is the urinary tract infection symptoms such as frequent micturition dysurea urgent micturition and chronic problem and increase with heating, aversion to cold, dizzy weak, nocturia in patient repeatedly without obvious inducement.Mental weariness during admission examination, inappetence, Nausea and vomiting, patient is middle upper abdomen or full abdomen pain sometimes, Zuo Shen district and the costispinal angle knocking positive.Laboratory and auxiliary examination: leukocyte raises, albuminuria +++, urine is occulted blood ++, two kidney b is super checks two inequality in size of kidneys.Adopt the Drug therapy assistance of acupuncture treatment of the present embodiment.After 6 days, patient's renal blood perfusion starts to increase, and glomerular filtration rate improves gradually, and urine creatine excretion increases gradually, and serum creatinine starts to decline gradually.Treat after 10 days, leave hospital.Follow the tracks of return visit two months, conditions of patients does not occur repeatedly, in good condition.Advise checking after six months.

Embodiment 3:

Standby medicine, prepares the composition of following parts by weight: bamboo 35, Os Draconis 15, Radix Angelicae Pubescentis 15, Pericarpium Citri Reticulatae 15, Herba Hedyotidis Diffusae 35, Herb Gynostemmae Pentaphylli 15, climbing entada seed 25, Herba Lophatheri 5, Radix Glycyrrhizae 55, Fructus Mume 5, Radix Pseudostellariae 15, Flos puerariae lobatae 15, Folium Nelumbinis 5, Fructus Citri Sarcodactylis 5, Herba Leonuri 5, Herba Andrographis 5, Fructus Gardeniae 5, Caulis Bambusae In Taenia 35, Fructus Chaenomelis 5, Radix Rehmanniae Preparata 30.

Preparation method and instructions of taking are with embodiment 1.

Patient is in so-and-so, male, people from Shanxi.One year over panesthesia to feel sick, weak, felt at that time be operating pressure excessive caused by, be not also present to the mind.But, after one month, just there is dizziness, headache, anorexia, a series of symptom such as uncomfortable in chest.Check to hospital, the Drug therapy of serum creatinine 490umol/L, blood pressure 230/170mmHg, employing embodiment 2, through the treatment of first stage one and a half months.Patient's spirit muscle power is recovered gradually, and renal function obviously recovers, and checks that serum creatinine controls to 400umol/L.Appetite is recovered.Again to hold a consultation result.Determine to adopt the Drug therapy of the present embodiment, mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid, increase the antiviral ability of patient, supplement kidney qi its muscles and bones strong, after 2 courses for the treatment of of second stage, renal function recovers gradually, check serum creatinine about 200umol/L.Rear patient leaves hospital voluntarily, suggestion continue to take two the course for the treatment of medicine, check after six months.

Through clinic trial statistics, choose person having renal failure 50 people that a variety of causes causes, cure 32 people, have clear improvement 15 people, invalid 2 people, and transfer from one hospital to another 1 people, and comprehensive cure rate is 64%, and effective percentage is 94%.

Claims

1. treat the medicine of renal failure, it is characterized in that being made up of the composition of following parts by weight: bamboo 15-55, Os Draconis 15-25, Radix Angelicae Pubescentis 15-25, Pericarpium Citri Reticulatae 15-25, Herba Hedyotidis Diffusae 15-45, Herb Gynostemmae Pentaphylli 15-25, climbing entada seed 15-35, Herba Lophatheri 5-15, Radix Glycyrrhizae 25-75, Fructus Mume 5-15, Radix Pseudostellariae 5-35, Flos puerariae lobatae 5-15, Folium Nelumbinis 5-15, Fructus Citri Sarcodactylis 5-15, Herba Leonuri 5-15, Herba Andrographis 5-15, Fructus Gardeniae 5-15, Caulis Bambusae In Taenia 15-55, Fructus Chaenomelis 5-15, Radix Rehmanniae Preparata 15-35.