WO2015078357A1

WO2015078357A1 - Medicament for treatment of renal failure and preparation method therefor

Info

Publication number: WO2015078357A1
Application number: PCT/CN2014/092164
Authority: WO
Inventors: 刘明杰
Original assignee: 刘明杰
Priority date: 2013-11-27
Filing date: 2014-11-25
Publication date: 2015-06-04
Also published as: CN104800626A; CN103656276B; CN103656276A; CN104758699A

Abstract

A medicament for treatment of renal failure and a preparation method therefor. Shiraia bambusicola, Fossilia ossis Mastodi, Angelica pubescens, dried tangerine peel, Hedyotis diffusa, Gynostemma pentaphyllum, and Bauhinia championii seed are used as active ingredients, while Lophatherum gracile, Glycyrrhiza uralensis, smoked Prunus mume seed, Pseudostellaria heterophylla, Pueraria lobata Ohwi、lotus leaf, Citrus medica var. sarcodactylis, Leonurus Artemisia, Andrographis paniculata, Gardenia jasminoides, Bambusae Caulis in Taeniam, papaya, and processed Rehmannia glutinosa are used as excipients. With the traditional Chinese medicine principles that kidneys are the congenital foundation and that kidneys rule water, kidney vital energy is cultivated and kidney fluids are regulated for differentiation and treatment of renal failure. Side effects are mitigated, great efficacy is provided, and patient suffering is alleviated.

Description

Medicine for treating renal failure and preparation method thereof

Technical field

The invention relates to a traditional Chinese medicine and a preparation method thereof, in particular to a medicine for treating renal failure and a preparation method thereof.

Background technique

Renal failure, nephrotic syndrome, can be caused by a variety of causes, with increased glomerular basement membrane permeability, characterized by a large number of proteinuria, hypoproteinemia, high edema, hyperlipidemia and other metabolic disorders. Group of clinical syndromes.

Nephrotic syndrome is divided into three major categories: primary, secondary and hereditary. Primary nephrotic syndrome belongs to primary glomerular disease. It is a common clinical condition with multiple pathological types. The current treatment is relatively simple. The available drugs are also relatively simple. And by a large part of the patient. There is a high probability of recurrence and recurrence after treatment. The pain caused to the patient is very large. The existing treatment methods for nephrotic syndrome are single, and the therapeutic drugs used have large side effects, and there is an urgent need for a drug with small side effects, obvious curative effect and relatively low cost to alleviate the patient's pain.

Summary of the invention

The object of the present invention is to provide a medicine for treating renal failure which has small side effects, high curative effect, and can alleviate the pain of a patient, and a preparation method thereof.

The medicine for treating renal failure according to the present invention comprises the following medicine for re-treatment of renal failure, which comprises the following components by weight: bamboo flower 15-55, keel 15-25, solo 15-25, tangerine peel 15-25, white flower Hedyotis grass 15-45, Gynostemma pentaphyllum 15-25, wood waist son 15-35, light bamboo leaf 5-15, licorice 25-75, ebony 5-15, Pseudostellariae 5-35, Gehua 5-15, lotus leaf 5- 15, bergamot 5-15, Motherwort 5-15, Andrographis paniculata 5-15, Gardenia 5-15, Bamboo Ru 15-55, Papaya 5-15, Rehmannia 15-35.

As a further improvement of the present invention, the parts by weight of the above components are as follows: bamboo flower 35-55, keel 15-25, solo 15-25, dried tangerine peel 15-25, Hedyotis diffusa 35-45, Gynostemma pentaphyllum 15-25, Wood waist 15-25, light bamboo leaves 5-15, licorice 55-75, ebony 5-15, Pseudostellariae 5-15, Gehua 5-15, lotus leaf 5-15, bergamot 5-15, motherwort 5-15, Andrographis paniculata 5-15, medlar 5-15, bamboo ruth 35-55, papaya 5-15, mature land 30-35.

The preparation method of the above medicine for treating renal failure includes the following steps in sequence:

A) Soak the bamboo flower, licorice, ebony, lotus leaf, bergamot, solitary, motherwort, andrographis, medlar, bamboo and radix in the above proportions in warm water of 20-30 °C for 4-6 hours, the weight of warm water The number is 800-1200; then put into a casserole to boil and boil for 10-20 minutes, then add light bamboo leaves, kudzu, tangerine peel, turn to low heat to keep boiling and continue to cook for 20-30 minutes, filter after natural cooling. Slag, get the No. 1 liquid; soak the keel, Pseudostellariae, papaya and wood waist into warm water 100-200 parts by weight of warm water for 4-6 hours, the temperature of warm water is 20-30 °C, then the keel, Prince The ginseng, papaya, wooden waist and its soaking liquid are put into the casserole, heated until the water boils, and further decocted for 50 minutes, the drug residue is filtered off, and the second liquid is obtained after natural cooling.

B) Mix the above-mentioned first drug solution No. 2 and the second drug solution into a casserole, heat it to boiling, add Hedyotis diffusa and Gynostemma pentaphyllum, keep boiling for more than 35 minutes, and naturally cool to obtain the treatment of renal failure. drug.

Bamboo flower, also known as bamboo yellow, Tianzhu flower, light bamboo flower, etc. belong to the fungi community, Ascomycete subphylum, nucleobacteria, Phaeodonta, Pleurotus, and Fungi. Born in the decay or decaying bamboo forest, the medicinal part is the sub-seat of the fungus bamboo yellow. It has the effects of antitussive and phlegm, qi and pain, and shock.

The keel is a fossil of bones of ancient mammals such as elephants, rhinos, and three-toed horses. The main function: the town is shocked and calmed, the sweat is solid, the bleeding is stopped, and the muscles are sore.

It is the dry root of the genus Umbelliferae, the spleen, bitter, lukewarm, used for wind and cold dampness; waist and knee pain; less yin and wind headache, headache and toothache. Modern research, anti-inflammatory, analgesic and sedative effects; inhibition of platelet aggregation; and antihypertensive effect, but not persistent; containing citrus lactone, xanthotoxin and other photosensitizing and anti-tumor effects.

Chenpi, alias: orange peel, expensive old, red skin, yellow orange peel, wide orange peel, new skin, orange peel, wide dried tangerine peel. It is the mature peel of the citrus plant orange and its cultivar. Regulate qi and spleen, dampness and phlegm. It is used for chest fullness, less vomiting and diarrhea, and more cough.

Hedyotis diffusa, scientific name: Hedyotis diffusa, is a plant of the genus Valeriana, commonly used in the treatment of lung heat and cough, sore throat, intestinal fistula, swollen sores, snake bites and so on.

Gynostemma pentaphyllum, the whole grass of the genus Gynostemma. Also known as paradise grass, evangelical grass, super ginseng, the bottom of the pot, the roots of the roots, the seven-leaf gall, the five-leaf ginseng and the seven-leaf ginseng. Taste bitter; slightly sweet; cool. Indications: physical weakness; deficiency of labor; leukopenia; hyperlipidemia; viral hepatitis; chronic gastroenteritis; chronic bronchitis.

The wooden waist is the seed of the tropical plant Jiulong. Sexual, sweet, and awkward. Indications: Insomnia and more dreams, children scared, stubborn rheumatism and so on.

Light bamboo leaves, a perennial herb, 40-90 cm high. Rhizome is short and hard. Not to be called scutellaria, pheasant rice grass, bamboo grass. Root medicinal, with cooling, antipyretic, diuretic and oxytocin effects.

Licorice, prescription name: licorice, grass, raw licorice, valerian, licorice, grass tips, licorice tips, grass tips. For the dicotyledonous Leguminosae licorice Glycyrrhiza uralensis Fisch., licorice G. inflataBat., or G. glabra L. roots and rhizomes. Indications to clear away heat and detoxification, phlegm and cough, abdominal abdomen and so on.

Wumei, alias sour plum, yellow abalone, He Hanmei, dried branch plum, is a near mature fruit of the deciduous tree plant Prunus mume of Rosaceae, which is smoked by pyrotechnics. According to modern research, ebony contains more potassium and less sodium. Therefore, it is necessary to take long-term use of potassium-sparing diuretics. The plum contains a variety of organic acids, which have the effect of improving liver function. Therefore, patients with liver disease should eat. It.

Taizishen, also known as baby ginseng and ginseng. It is the root of the perennial herbaceous plant of the Dianthus family. Sweet, slightly bitter, lukewarm. Tonic medicine, qi medicine. Indications: Replenishing spleen and lung, benefiting Qi and fluid.

Gehua, a dried flower of the leguminous plant Puerarialobata (Willd.) Ohwi. It has the functions of clearing heat, detoxifying, protecting liver, nourishing the skin and tonifying the kidney.

Lotus leaf, prescription name: lotus leaf, lotus leaf, fresh lotus leaf, dry lotus leaf, lotus leaf charcoal, etc. It is the dry leaf of the lotus plant lily. It has the effects of eliminating heat and dampness, strengthening the spleen and promoting yang, and relieving blood stasis.

The bergamot, also known as the nine-clawed wood, the five-finger orange, the bergamot, is the fruit of the genus Citrus medica L.var.sarcodactylis Swingle. Xin, bitter, sweet, warm, non-toxic; into the liver, spleen, stomach three meridians, rational gasification, vomiting and swelling, Shugan Jianpi, and the stomach more medicinal functions.

Motherwort, the whole grass of the motherwort of the Labiatae family. The roots, stems, flowers, leaves, and reals of Motherwort are all used as medicines. Bitter, Xin, slightly cold. Go to the liver, pericardium. Indications: blood circulation, diuretic swelling. Andrographis paniculata, the whole grass or leaf of Andrographis paniculata (Burm.f.) Nees. Also known as Chunlian Qiu Liu, I saw hi, nucleus lotus, bitter grass, golden vanilla, golden ear hook, Indian grass, bitter grass and so on. It has the effects of clearing away heat and detoxifying, reducing inflammation, reducing swelling and relieving pain.

The scorpion, alias Huang Zizi, Hawthorn, and White Stork, is the fruit of the scorpion of the Rubiaceae plant. At present, the fruit of scorpion is a traditional Chinese medicine, which is the first batch of medicine and food resources promulgated by the Ministry of Health. It has the functions of protecting liver, choleretic, antihypertensive, sedative, hemostasis and swelling. It is commonly used in the treatment of jaundice hepatitis, contusion, hypertension, diabetes and other diseases in Chinese medicine.

Zhuru, also known as bamboo skin, green bamboo Ru, light bamboo skin Ru. Is a gramineous plant, green stalk bamboo, big head bamboo or A dry intermediate layer of stalks of light bamboo. Contains lignin and cellulose. Slightly cold, sweet. Traditional Chinese medicine is often used for lung heat cough, phlegm and irritability, convulsions.

Papaya, a dried near-mature fruit of the Rosaceae plant Chaenomeles speciosa (Sweet Nakai.). Sexual taste: sour, warm. Liver, spleen. Indications: Pinggan Shujin, and stomach and dampness. It is used for wet warts, waist and knee joints, soreness, vomiting and diarrhea, and athlete's foot edema.

Rehmannia, the root of the plant of the genus Scrophulariae (Rehmannia glutinosa), also known as Rehmannia glutinosa, is processed and processed. It has the effect of nourishing blood and nourishing yin. It can be used for blood deficiency, sallowness, dizziness, palpitations, insomnia, irregular menstruation, uterine bleeding, etc. It can also be used for hot flash steaming, night sweats, nocturnal emission, and thirst quenching.

The medicine for treating renal failure according to the invention is bamboo flower, keel, Duhuo, tangerine peel, Hedyotis diffusa, Gynostemma pentaphyllum, and wood waist, and the main medicines are light bamboo, licorice, ebony, ginseng, geranium, lotus leaf, bergamot and motherwort. , Andrographis paniculata, medlar, bamboo ru, papaya, and rehmannia are auxiliary drugs. The principle of kidney medicine is the essence of the kidney, the principle of kidney water transport, kidney water, syndrome differentiation and treatment of renal failure, small side effects and high curative effect. Can alleviate the patient's illness.

detailed description

Example 1:

Preparation of the preparation, the following preparation methods for the preparation of the following parts by weight: bamboo flower 15-55, keel 15-25, solo 15-25, tangerine peel 15-25, Hedyotis diffusa 15-45, Gynostemma 15-25, wooden waist 15 —35, light bamboo leaves 5-15, licorice 25-75, ebony 5-15, ginseng ginseng 5-35, geisha 5-15, lotus leaf 5-15, bergamot 5-15, motherwort 5-15, andrographis paniculata 5- 15. Scorpion 5-15, Zhuru 15-55, papaya 5-15, and mature land 15-35. The content of the above specific components can be adjusted within the above range depending on the characteristics of the adapted condition and the source of the raw material.

The method of administration is as follows: the above-mentioned medicine for treating renal failure is divided into one dose per 50 grams, taken three times a day, one oral dose per administration, and one treatment every 15 days.

Patient Wang Ms., 31 years old. The whole person is mentally exhausted, his face is slim, his body is thin, and his physical condition is very poor. The test results report showed: serum creatinine 716 μmol / L, urine protein ++, blood uric acid 502.7umol / L, urea nitrogen 28.2mmol / L. B-ultrasound showed that the patient's kidneys had shrunk, the left kidney was 7.5 cm, and the right kidney was 7.9 cm. The comprehensive diagnosis results of the indicators are: middle and advanced uremia, kidney atrophy, hyperuricemia. According to the patient's kidney examination index, the degree of kidney damage of the patient is determined. After one month of treatment with the drug of this embodiment, the spirit is sufficient, the color is good, the walking is strong, the amount of rice is increased, and the sleep is normal. Serum creatinine decreased to 324umol/L, blood uric acid decreased to 436 micromolar, and urea nitrogen decreased to 18.5. After the second month, creatinine decreased by 85umol/L and urea nitrogen decreased by 5mmol/L. Both carbon dioxide binding and blood uric acid reached normal levels. After the third month, most of the indicators were normal. The condition is now stable. The physical condition has improved significantly and I can do farm work.

Example 2:

Prepare the medicine, prepare the following parts by weight: bamboo flower 35-55, keel 15-25, solo 15-25, dried tangerine peel 15-25, Hedyotis diffusa 35-45, Gynostemma pentaphyllum 15-25, wooden waist 15-25, Light bamboo leaves 5-15, licorice 55-75, ebony 5-15, ginseng ginseng 5-15, geisha 5-15, lotus leaf 5-15, bergamot 5-15, motherwort 5-15, andrographis paniculata 5-15 Sub 5-15, Zhuru 35-55, papaya 5-15, and mature land 30-35. The content of the above specific components can be adjusted within the above range depending on the characteristics of the adapted condition and the source of the raw material.

The preparation method and administration method are the same as those in Example 1.

Patient Hou Moumou, male, 34 years old. In the past 5 years, the patient has no obvious cause of recurrent urinary frequency, urinary pain, urgency and other urinary tract irritation and waist discomfort, accompanied by fever, aversion to cold, dizziness and fatigue, and increased nocturia. In the examination, he was mentally tired, loss of appetite, nausea, vomiting, and sometimes patients with upper or lower abdominal pain. The left kidney area and the ribs were positive for slamming. Laboratory and auxiliary examination: elevated white blood cells, proteinuria +++, urinary occult blood ++, double kidney b-examination of kidney size. The drug treatment of the present embodiment is used to assist acupuncture treatment. After 6 days, the renal blood perfusion began to increase, the glomerular filtration rate increased gradually, the urinary creatinine excretion gradually increased, and serum creatinine gradually began to decline. After 10 days of treatment, he was discharged. After tracking the return visit for two months, the patient's condition did not repeat and the condition was good. It is recommended to review it after six months.

Example 3:

Preparation, prepare the following parts by weight: bamboo flower 35, keel 15, 独活 15, 皮皮15, Hedyotis diffusa 35, Gynostemma 15, wood waist 25, light bamboo leaves 5, licorice 55, ebony 5, Taizishen 15, Gehua 15, Lotus Leaf 5, Bergamot 5, Motherwort 5, Andrographis 5, Scorpion 5, Zhuru 35, Papaya 5, Rehmannia 30.

The patient is in a certain, male, Shanxi. I felt nausea and fatigue for more than a year. I felt that it was work. It was caused by excessive pressure and was not taken care of. However, a month later, there were a series of symptoms such as dizziness, headache, anorexia, and chest tightness. Go to the hospital for examination, serum creatinine 490umol / L, blood pressure 230 / 170mmHg, using the drug treatment of Example 2, after the first phase of treatment for one and a half months. The patient's mental strength gradually recovered, renal function recovered significantly, and blood creatinine was controlled to 400umol/L. Appetite recovery. The result of the consultation again. Decided to use the drug treatment of this example, replenishing spleen and lung, replenishing qi and fluid, increasing the patient's ability to resist viruses, supplementing the kidney and strengthening his muscles and bones. After the second phase of 2 courses, the renal function gradually recovered, and the serum creatinine 200umol/L was reviewed. about. After the patient was discharged from the hospital, it is recommended to continue taking two courses of medication and review it six months later.

According to the statistics of clinical trials, 50 patients with renal failure caused by various reasons were selected, 32 were cured, 15 were obviously improved, 2 were invalid, 1 was transferred, the comprehensive cure rate was 64%, and the effective rate was 94%.

Claims

The medicine for treating renal failure is characterized by comprising the following components by weight: bamboo flower 15-55, keel 15-25, solo 15-25, dried tangerine peel 15-25, Hedyotis diffusa 15-45, Gynostemma pentaphyllum 15-25, Wood waist 15-35, light bamboo leaves 5-15, licorice 25-75, ebony 5-15, ginseng ginseng 5-35, geisha 5-15, lotus leaf 5-15, bergamot 5-15, motherwort 5-15, Andrographis paniculata 5-15, medlar 5-15, bamboo rug 15-55, papaya 5-15, mature land 15-35.
The medicine for treating renal failure according to claim 1, characterized in that the parts by weight of each component are as follows: bamboo flower 35-55, keel 15-25, solo 15-25, tangerine peel 15-25, Hedyotis diffusa 35- 45, Gynostemma 15-25, wood waist 15-25, light bamboo leaves 5-15, licorice 55-75, ebony 5-15, Pseudostellariae 5-15, Gehua 5-15, lotus leaf 5-15, bergamot 5 15. Motherwort 5-15, Andrographis paniculata 5-15, Gardenia 5-15, Bamboo Ru 35-55, Papaya 5-15, Rehmannia 30-35.
The method for preparing a drug for treating renal failure according to claim 1 or 2, characterized by comprising the steps of:

A) Soak the bamboo flower, licorice, ebony, lotus leaf, bergamot, solitary, motherwort, andrographis, medlar, bamboo and radix in the above proportions in warm water of 20-30 °C for 4-6 hours, the weight of warm water The number is 800-1200; then put into a casserole to boil and boil for 10-20 minutes, then add light bamboo leaves, kudzu, tangerine peel, turn to low heat to keep boiling and continue to cook for 20-30 minutes, filter after natural cooling. Slag, get the No. 1 liquid; soak the keel, Pseudostellariae, papaya and wood waist into warm water 100-200 parts by weight of warm water for 4-6 hours, the temperature of warm water is 20-30 °C, then the keel, Prince The ginseng, papaya, wooden waist and its soaking liquid are put into the casserole, heated until the water boils and further decocted for 50 minutes, the drug residue is filtered off, and the second liquid is obtained after natural cooling;

B) Mix the above-mentioned first drug solution No. 2 and the second drug solution into a casserole, heat it to boiling, add Hedyotis diffusa and Gynostemma pentaphyllum, keep boiling and continue to cook for 35 minutes. After natural cooling, the treatment of renal failure is obtained. Exhausted drugs.