CN103649106B - 用于治疗神经退行性和缺血性脑疾病的化合物和药学组合 - Google Patents

用于治疗神经退行性和缺血性脑疾病的化合物和药学组合 Download PDF

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CN103649106B
CN103649106B CN201280032375.5A CN201280032375A CN103649106B CN 103649106 B CN103649106 B CN 103649106B CN 201280032375 A CN201280032375 A CN 201280032375A CN 103649106 B CN103649106 B CN 103649106B
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pcb
ifn
seq
peptide
epo
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CN103649106A (zh
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G·彭顿罗尔
A·劳彼兹阿苏亚加
J·马林普赖达
E·彭顿阿里亚斯
E·罗德里格斯希门尼斯
A·穆萨奇奥拉萨
V·A·贝萨达佩雷斯
G·L·帕多安德鲁
L·J·冈萨雷斯洛佩斯
N·帕翁富恩特斯
G·E·吉伦涅托
P·A·洛佩斯绍拉
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Centro de Ingenieria Genetica y Biotecnologia CIGB
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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CN201280032375.5A 2011-07-01 2012-06-29 用于治疗神经退行性和缺血性脑疾病的化合物和药学组合 Active CN103649106B (zh)

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CU2011000146A CU23963B1 (es) 2011-07-01 2011-07-01 Composiciones farmacéuticas a partir de derivados de la c-ficocianina y combinaciones con interferones del tipo i para el tratamiento de enfermedades cerebrales isquémicas y neurodegenerativas
CU2011/0146 2011-07-01
PCT/CU2012/000003 WO2013004203A1 (es) 2011-07-01 2012-06-29 Compuestos y combinaciones farmacéuticas para el tratamiento de enfermedades cerebrales isquemicas y neurodegenerativas

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Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
EP3013355B1 (en) * 2013-06-25 2019-08-07 ICM - Institut du Cerveau et da la Moelle Epinière Il-2 for use in treating alzheimer disease and related disorders
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
RU2613765C1 (ru) * 2016-01-26 2017-03-21 Федеральное государственное автономное образовательное учреждение высшего образования "Северо-Восточный федеральный университет им. М.К.Аммосова" Способ лечения спиноцеребеллярной атаксии
CN108752445B (zh) * 2018-06-20 2021-04-30 广东药科大学 一种螺旋藻蛋白的制备工艺及其神经保护用途
KR102152407B1 (ko) * 2019-02-26 2020-09-07 (주)나우코스 스피루리나에서 유래한 파이코시아노블린 및 이의 유도체를 유효성분으로 포함하는 화장료 조성물
KR20210091664A (ko) 2020-01-14 2021-07-22 경북대학교 산학협력단 중간엽 줄기세포 유래 단백질을 포함하는 소뇌성운동실조증의 치료 예후를 예측하기 위한 바이오마커, 및 이를 이용한 소뇌성운동실조증의 치료용 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709855A (en) 1995-09-22 1998-01-20 Bockow; Barry I. Compositions of spirulina algae and omega fatty acids for treatment of inflammation and pain
US20040110938A1 (en) * 2000-02-24 2004-06-10 Parekh Rajesh Bhikhu Proteins, genes and their use for diagnosis and treatment of schizophrenia
US7025965B1 (en) * 2003-02-12 2006-04-11 Pharma Chemie, Inc. Method of use and dosage composition of bluegreen algae extract for inflammation in animals
PL1608400T3 (pl) * 2003-03-28 2010-11-30 Faron Pharmaceuticals Oy Podwyższanie poziomu adenozyny przez indukowaną przez cytokiny ekspresję CD73
CU23581A1 (es) * 2005-10-28 2010-10-30 Ct Ingenieria Genetica Biotech Interferon alfa y c-ficocianina para el tratamiento de enfermedades autoinmunes, alérgicas y cáncer
HRP20110771T1 (hr) * 2006-06-27 2011-11-30 Nutratec S.R.L. Pripravak od cvjetova aphanizomenona, njegovi ekstrakti i pročišćene komponente za tretman neuroloških i neurodegenerativnih poremećaja te raspoloženja
EP3597188A1 (en) * 2006-11-13 2020-01-22 PCB Associates, Inc. An isolated phycobilin for use in a method for prophylaxis or treatment of a medical condition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Bilin Attachment Sites in the a! and /3 Subunits of B-Phycoerythrin;Daniel J. Lundell;《THE JOURNAL OF BIOLOGICAL CHEMIST》;19841231;第259卷(第9期);pp. 5472-5480 *
Chromopeptides from C-phycocyanin. Structure and linkage of a phycocyanobilin bound to the .beta. subunit;J. Clark Lagarias , Alexander N. Glazer , Henry Rapoport;《J. Am. Chem. Soc》;19791231;第101卷(第17期);pp 5030–5037 *
In Vitro Attachment of Bilins to Apophycocyanin. 111. PROPERTIES OF THE PHYCOERYTHROBILIN ADDUCT;David M. Arciero;《J Biol Chem.》;19881205;第263卷(第34期);18358-18363 *

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CA2838496A1 (en) 2013-01-10
EP2733149A1 (en) 2014-05-21
IN2014CN00510A (enExample) 2015-04-03
KR20140078601A (ko) 2014-06-25
US9518085B2 (en) 2016-12-13
CU20110146A7 (es) 2013-02-26
BR112013033970A2 (pt) 2017-02-14
CU23963B1 (es) 2013-12-11
ZA201309554B (en) 2014-08-27
DK2733149T3 (en) 2016-11-28
JP2014520764A (ja) 2014-08-25
CA2838496C (en) 2020-01-07
CN103649106A (zh) 2014-03-19
MX2013015206A (es) 2014-02-20
AR087034A1 (es) 2014-02-05
ES2601887T3 (es) 2017-02-16
US20140356319A1 (en) 2014-12-04
SI2733149T1 (sl) 2017-01-31
BR112013033970B1 (pt) 2022-10-18
WO2013004203A1 (es) 2013-01-10
KR101987978B1 (ko) 2019-06-11
JP6023803B2 (ja) 2016-11-09
MX345534B (es) 2017-02-03
EP2733149B9 (en) 2019-05-15
RU2014103246A (ru) 2015-08-10
EP2733149B1 (en) 2016-09-28
AU2012280776A1 (en) 2014-01-23
RU2569302C2 (ru) 2015-11-20
US20170119733A1 (en) 2017-05-04
AU2012280776B2 (en) 2016-07-14

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