CN103649078B - 取代的苯基化合物 - Google Patents
取代的苯基化合物 Download PDFInfo
- Publication number
- CN103649078B CN103649078B CN201280033988.0A CN201280033988A CN103649078B CN 103649078 B CN103649078 B CN 103649078B CN 201280033988 A CN201280033988 A CN 201280033988A CN 103649078 B CN103649078 B CN 103649078B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- protecting group
- compounds
- pyrrolidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CNC1C(*)C1 Chemical compound CNC1C(*)C1 0.000 description 4
- MJHLFDZNTKULCZ-UHFFFAOYSA-N O=C1NC=Cc2cc(OC3CNCC3)ccc12 Chemical compound O=C1NC=Cc2cc(OC3CNCC3)ccc12 MJHLFDZNTKULCZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305892 | 2011-07-08 | ||
| EP11305892.9 | 2011-07-08 | ||
| PCT/EP2012/062202 WO2013007502A1 (en) | 2011-07-08 | 2012-06-25 | Substituted phenyl compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103649078A CN103649078A (zh) | 2014-03-19 |
| CN103649078B true CN103649078B (zh) | 2015-08-19 |
Family
ID=46397237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280033988.0A Active CN103649078B (zh) | 2011-07-08 | 2012-06-25 | 取代的苯基化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8785642B2 (enExample) |
| EP (1) | EP2729463B1 (enExample) |
| JP (1) | JP6030644B2 (enExample) |
| KR (1) | KR101959711B1 (enExample) |
| CN (1) | CN103649078B (enExample) |
| AU (1) | AU2012283335B2 (enExample) |
| BR (1) | BR112014000279B1 (enExample) |
| CA (1) | CA2837150C (enExample) |
| HU (1) | HUE025936T2 (enExample) |
| IL (1) | IL230312A (enExample) |
| MX (1) | MX352295B (enExample) |
| MY (1) | MY161361A (enExample) |
| RU (1) | RU2592696C2 (enExample) |
| WO (1) | WO2013007502A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250036929A (ko) | 2022-08-01 | 2025-03-14 | 발로 헬스, 인코포레이티드 | 6-치환된-1-(2h)-아이소퀴놀리논 및 중간체 화합물의 제조 방법 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732245A (en) * | 1970-11-04 | 1973-05-08 | Hoffmann La Roche | Process and intermediates for the preparation of indoles from ortho-nitrotoluenes |
| CN101910123A (zh) * | 2007-12-26 | 2010-12-08 | 塞诺菲-安万特股份有限公司 | 6-取代的-1-(2h)-异喹啉酮的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ565668A (en) | 2005-07-26 | 2010-09-30 | Sanofi Aventis | Piperidinyl-substituted isoquinolone derivatives as RHO-kinase inhibitors |
| TW200738682A (en) | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| GB0605766D0 (en) * | 2006-03-22 | 2006-05-03 | Ucb Sa | Process |
| RU2455302C2 (ru) | 2006-12-27 | 2012-07-10 | Санофи-Авентис | ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| TW200938542A (en) * | 2008-02-01 | 2009-09-16 | Irm Llc | Compounds and compositions as kinase inhibitors |
-
2012
- 2012-06-25 MY MYPI2013004203A patent/MY161361A/en unknown
- 2012-06-25 BR BR112014000279-7A patent/BR112014000279B1/pt active IP Right Grant
- 2012-06-25 JP JP2014517625A patent/JP6030644B2/ja active Active
- 2012-06-25 KR KR1020147003093A patent/KR101959711B1/ko active Active
- 2012-06-25 CN CN201280033988.0A patent/CN103649078B/zh active Active
- 2012-06-25 CA CA2837150A patent/CA2837150C/en active Active
- 2012-06-25 RU RU2014104378/04A patent/RU2592696C2/ru active
- 2012-06-25 AU AU2012283335A patent/AU2012283335B2/en active Active
- 2012-06-25 MX MX2013014350A patent/MX352295B/es active IP Right Grant
- 2012-06-25 HU HUE12730498A patent/HUE025936T2/en unknown
- 2012-06-25 EP EP12730498.8A patent/EP2729463B1/en active Active
- 2012-06-25 WO PCT/EP2012/062202 patent/WO2013007502A1/en not_active Ceased
- 2012-06-27 US US13/534,698 patent/US8785642B2/en active Active
-
2014
- 2014-01-02 IL IL230312A patent/IL230312A/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732245A (en) * | 1970-11-04 | 1973-05-08 | Hoffmann La Roche | Process and intermediates for the preparation of indoles from ortho-nitrotoluenes |
| CN101910123A (zh) * | 2007-12-26 | 2010-12-08 | 塞诺菲-安万特股份有限公司 | 6-取代的-1-(2h)-异喹啉酮的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8785642B2 (en) | 2014-07-22 |
| CA2837150C (en) | 2019-04-02 |
| JP6030644B2 (ja) | 2016-11-24 |
| CA2837150A1 (en) | 2013-01-17 |
| CN103649078A (zh) | 2014-03-19 |
| EP2729463B1 (en) | 2015-07-29 |
| MX2013014350A (es) | 2014-01-31 |
| EP2729463A1 (en) | 2014-05-14 |
| KR101959711B1 (ko) | 2019-03-19 |
| RU2014104378A (ru) | 2015-08-20 |
| HUE025936T2 (en) | 2016-05-30 |
| KR20140047115A (ko) | 2014-04-21 |
| AU2012283335A1 (en) | 2014-01-16 |
| BR112014000279B1 (pt) | 2020-11-24 |
| AU2012283335B2 (en) | 2016-09-01 |
| HK1192246A1 (en) | 2014-08-15 |
| BR112014000279A2 (pt) | 2016-08-23 |
| MX352295B (es) | 2017-11-17 |
| WO2013007502A1 (en) | 2013-01-17 |
| JP2014518230A (ja) | 2014-07-28 |
| US20130012711A1 (en) | 2013-01-10 |
| MY161361A (en) | 2017-04-14 |
| RU2592696C2 (ru) | 2016-07-27 |
| IL230312A (en) | 2016-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |