BR112014000279A2 - "composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i)". - Google Patents

"composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i)".

Info

Publication number
BR112014000279A2
BR112014000279A2 BR112014000279A BR112014000279A BR112014000279A2 BR 112014000279 A2 BR112014000279 A2 BR 112014000279A2 BR 112014000279 A BR112014000279 A BR 112014000279A BR 112014000279 A BR112014000279 A BR 112014000279A BR 112014000279 A2 BR112014000279 A2 BR 112014000279A2
Authority
BR
Brazil
Prior art keywords
formula
compound
preparation process
preparation
substituted phenyl
Prior art date
Application number
BR112014000279A
Other languages
English (en)
Other versions
BR112014000279B1 (pt
Inventor
Simon Dr Gessler
Theo Dr Wollmann
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112014000279A2 publication Critical patent/BR112014000279A2/pt
Publication of BR112014000279B1 publication Critical patent/BR112014000279B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

resumo patente de invenção: "compostos de fenila substituídos". a presente invenção refere-se a novos compostos de fenila substituídos de fórmula vi (vi) e a um processo para produzi-los. os compostos podem ser usados como intermediários para a produção de derivados de 1-(2h)-isoquinolinona substituída na posição 6.
BR112014000279-7A 2011-07-08 2012-06-25 composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i) BR112014000279B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11305892 2011-07-08
EP11305892.9 2011-07-08
PCT/EP2012/062202 WO2013007502A1 (en) 2011-07-08 2012-06-25 Substituted phenyl compounds

Publications (2)

Publication Number Publication Date
BR112014000279A2 true BR112014000279A2 (pt) 2016-08-23
BR112014000279B1 BR112014000279B1 (pt) 2020-11-24

Family

ID=46397237

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014000279-7A BR112014000279B1 (pt) 2011-07-08 2012-06-25 composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i)

Country Status (15)

Country Link
US (1) US8785642B2 (pt)
EP (1) EP2729463B1 (pt)
JP (1) JP6030644B2 (pt)
KR (1) KR101959711B1 (pt)
CN (1) CN103649078B (pt)
AU (1) AU2012283335B2 (pt)
BR (1) BR112014000279B1 (pt)
CA (1) CA2837150C (pt)
HK (1) HK1192246A1 (pt)
HU (1) HUE025936T2 (pt)
IL (1) IL230312A (pt)
MX (1) MX352295B (pt)
MY (1) MY161361A (pt)
RU (1) RU2592696C2 (pt)
WO (1) WO2013007502A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024030854A1 (en) 2022-08-01 2024-02-08 Valo Health, Inc. Process for preparing 6-substituted-1-(2h)-isoquinolinones and intermediate compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732245A (en) * 1970-11-04 1973-05-08 Hoffmann La Roche Process and intermediates for the preparation of indoles from ortho-nitrotoluenes
EP1910333B1 (en) 2005-07-26 2013-05-22 Sanofi Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors
TW200738682A (en) 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives
GB0605766D0 (en) * 2006-03-22 2006-05-03 Ucb Sa Process
CA2673916C (en) 2006-12-27 2015-02-17 Sanofi-Aventis Substituted isoquinolone and isoquinolinone derivatives as inhibitors of rho-kinase
EP2240441B1 (en) * 2007-12-26 2015-06-03 Sanofi Process for the preparation of 6-substituted-1-(2h)-isoquinolinones
TW200942537A (en) * 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors

Also Published As

Publication number Publication date
AU2012283335A1 (en) 2014-01-16
MX2013014350A (es) 2014-01-31
MX352295B (es) 2017-11-17
HK1192246A1 (en) 2014-08-15
KR20140047115A (ko) 2014-04-21
CN103649078A (zh) 2014-03-19
WO2013007502A1 (en) 2013-01-17
IL230312A (en) 2016-08-31
EP2729463B1 (en) 2015-07-29
CN103649078B (zh) 2015-08-19
EP2729463A1 (en) 2014-05-14
BR112014000279B1 (pt) 2020-11-24
CA2837150C (en) 2019-04-02
HUE025936T2 (en) 2016-05-30
MY161361A (en) 2017-04-14
RU2592696C2 (ru) 2016-07-27
CA2837150A1 (en) 2013-01-17
JP6030644B2 (ja) 2016-11-24
US20130012711A1 (en) 2013-01-10
KR101959711B1 (ko) 2019-03-19
US8785642B2 (en) 2014-07-22
AU2012283335B2 (en) 2016-09-01
JP2014518230A (ja) 2014-07-28
RU2014104378A (ru) 2015-08-20

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BR112014000279A2 (pt) "composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i)".
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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/06/2012, OBSERVADAS AS CONDICOES LEGAIS.