CA2837150C - Substituted phenyl compounds - Google Patents

Substituted phenyl compounds Download PDF

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Publication number
CA2837150C
CA2837150C CA2837150A CA2837150A CA2837150C CA 2837150 C CA2837150 C CA 2837150C CA 2837150 A CA2837150 A CA 2837150A CA 2837150 A CA2837150 A CA 2837150A CA 2837150 C CA2837150 C CA 2837150C
Authority
CA
Canada
Prior art keywords
compound
formula
protecting group
pyrrolidine
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2837150A
Other languages
English (en)
French (fr)
Other versions
CA2837150A1 (en
Inventor
Simon Gessler
Theo Wollmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of CA2837150A1 publication Critical patent/CA2837150A1/en
Application granted granted Critical
Publication of CA2837150C publication Critical patent/CA2837150C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
CA2837150A 2011-07-08 2012-06-25 Substituted phenyl compounds Active CA2837150C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11305892 2011-07-08
EP11305892.9 2011-07-08
PCT/EP2012/062202 WO2013007502A1 (en) 2011-07-08 2012-06-25 Substituted phenyl compounds

Publications (2)

Publication Number Publication Date
CA2837150A1 CA2837150A1 (en) 2013-01-17
CA2837150C true CA2837150C (en) 2019-04-02

Family

ID=46397237

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2837150A Active CA2837150C (en) 2011-07-08 2012-06-25 Substituted phenyl compounds

Country Status (14)

Country Link
US (1) US8785642B2 (enExample)
EP (1) EP2729463B1 (enExample)
JP (1) JP6030644B2 (enExample)
KR (1) KR101959711B1 (enExample)
CN (1) CN103649078B (enExample)
AU (1) AU2012283335B2 (enExample)
BR (1) BR112014000279B1 (enExample)
CA (1) CA2837150C (enExample)
HU (1) HUE025936T2 (enExample)
IL (1) IL230312A (enExample)
MX (1) MX352295B (enExample)
MY (1) MY161361A (enExample)
RU (1) RU2592696C2 (enExample)
WO (1) WO2013007502A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250036929A (ko) 2022-08-01 2025-03-14 발로 헬스, 인코포레이티드 6-치환된-1-(2h)-아이소퀴놀리논 및 중간체 화합물의 제조 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732245A (en) 1970-11-04 1973-05-08 Hoffmann La Roche Process and intermediates for the preparation of indoles from ortho-nitrotoluenes
PT1910333E (pt) * 2005-07-26 2013-08-01 Sanofi Sa Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase
TW200738682A (en) 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives
GB0605766D0 (en) * 2006-03-22 2006-05-03 Ucb Sa Process
JP5421783B2 (ja) 2006-12-27 2014-02-19 サノフイ Rhoキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体
KR20100103646A (ko) * 2007-12-26 2010-09-27 사노피-아벤티스 6­치환된­1­(2h)­이소퀴놀리논의 제조 방법
TW200942537A (en) * 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors

Also Published As

Publication number Publication date
HUE025936T2 (en) 2016-05-30
IL230312A (en) 2016-08-31
AU2012283335B2 (en) 2016-09-01
MY161361A (en) 2017-04-14
CN103649078A (zh) 2014-03-19
US20130012711A1 (en) 2013-01-10
EP2729463A1 (en) 2014-05-14
EP2729463B1 (en) 2015-07-29
KR101959711B1 (ko) 2019-03-19
WO2013007502A1 (en) 2013-01-17
BR112014000279A2 (pt) 2016-08-23
MX352295B (es) 2017-11-17
JP2014518230A (ja) 2014-07-28
KR20140047115A (ko) 2014-04-21
RU2592696C2 (ru) 2016-07-27
CA2837150A1 (en) 2013-01-17
US8785642B2 (en) 2014-07-22
CN103649078B (zh) 2015-08-19
MX2013014350A (es) 2014-01-31
RU2014104378A (ru) 2015-08-20
JP6030644B2 (ja) 2016-11-24
BR112014000279B1 (pt) 2020-11-24
AU2012283335A1 (en) 2014-01-16
HK1192246A1 (en) 2014-08-15

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