CN103627711B - 胰岛素样生长因子重组乳酸菌及其应用 - Google Patents
胰岛素样生长因子重组乳酸菌及其应用 Download PDFInfo
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- CN103627711B CN103627711B CN201310716773.5A CN201310716773A CN103627711B CN 103627711 B CN103627711 B CN 103627711B CN 201310716773 A CN201310716773 A CN 201310716773A CN 103627711 B CN103627711 B CN 103627711B
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- acid bacteria
- rhigf
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Abstract
Description
顺式作用元件 | 优化后 | 优化前 |
结合位点(GGTAAG) | 0 | 1 |
结合位点(GGTGAT) | 0 | 0 |
PolyA(AATAAA) | 0 | 1 |
PolyA(ATTAAA) | 0 | 0 |
不稳定序列(ATTTA) | 0 | 0 |
PolyT(TTTTTT) | 0 | 0 |
PolyA(AAAAAAA) | 0 | 0 |
优化后 | 优化前 | |
最大同向重复序列 | None | Size:8 Distance:116 Frequency:2 |
最大反向重复序列 | None | None |
最大对向重复序列 | None | None |
Claims (10)
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CN201310716773.5A CN103627711B (zh) | 2013-12-23 | 2013-12-23 | 胰岛素样生长因子重组乳酸菌及其应用 |
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CN201310716773.5A CN103627711B (zh) | 2013-12-23 | 2013-12-23 | 胰岛素样生长因子重组乳酸菌及其应用 |
Publications (2)
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CN103627711A CN103627711A (zh) | 2014-03-12 |
CN103627711B true CN103627711B (zh) | 2016-01-06 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103911338A (zh) * | 2014-03-27 | 2014-07-09 | 浙江中医药大学 | 基于原核密码子偏好性构建高表达igf-1基因的工程菌 |
CN106366201A (zh) * | 2016-09-20 | 2017-02-01 | 南京农业大学 | 融合蛋白damp4‑igf‑1的基因序列、载体、重组菌株、重组蛋白及其制备方法 |
CN112831516A (zh) * | 2021-02-08 | 2021-05-25 | 青岛海华莱康生物医药技术有限公司 | 一种表达glp-1样因子的重组菌及应用 |
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2013
- 2013-12-23 CN CN201310716773.5A patent/CN103627711B/zh active Active
Non-Patent Citations (2)
Title |
---|
Gao G等.Functional expression of mouse insulin-like growth factor-I with food-grade vector in Lactococcus lactis NZ9000.《Lett Appl Microbiol》.2012,第54卷(第5期),摘要. * |
Insulin-Like Growth Factor-I Signaling Regulates miRNA Expression in MCF-7 Breast Cancer Cell Line;Elizabeth C. Martin等;《PLOS ONE》;20121130;全文 * |
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