CN103610897A - Traditional Chinese medicine composition with effects of treatment, cough relieving and phlegm expelling, preparation method and application thereof - Google Patents
Traditional Chinese medicine composition with effects of treatment, cough relieving and phlegm expelling, preparation method and application thereof Download PDFInfo
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- CN103610897A CN103610897A CN201310480018.1A CN201310480018A CN103610897A CN 103610897 A CN103610897 A CN 103610897A CN 201310480018 A CN201310480018 A CN 201310480018A CN 103610897 A CN103610897 A CN 103610897A
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Abstract
The present invention belongs to the technical field of medicine, specifically discloses a traditional Chinese medicine composition with effects of treatment, cough relieving and phlegm expelling, and concurrently provides a preparation method and an application of the traditional Chinese medicine composition. Results of a lot of research tests performed by technical staffs show that a significant cough relieving and phlegm expelling pharmacological effect is provided when 60-120 g of white mulberry root bark, 60-120 g of ansu apricot seed, 80-160 g of chekiang fritillary bulb, 10-20 g of licorice root and 30-60 g of thinleaf milkwort root are adopted, and the bulk drug formula is prepared according to a ratio of white mulberry root bark to ansu apricot seed to chekiang fritillary bulb to licorice root to thinleaf milkwort root of 6:6:8:1:3.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine composition of eliminating phlegm and stopping cough and preparation method and application of said composition for the treatment of.
Background technology
Coughing, coughing up phlegm is two common large symptoms of respiratory system disease, more may not develop into emphysema, bronchiectasis, pulmonary heart disease etc. for a long time, and in etiological treatment, reasonably application cough medicine and expectorant are very important in time.In children, most of expelling phlegm for arresting cough medicine is selected chemical medicine, causes children addiction, and dependency is very strong, and life-time service causes drug resistance.The present invention studies a kind of Chinese medicine preparation, and the effect for the treatment of eliminating phlegm and stopping cough is remarkable, can not cause the problem of children addiction simultaneously.
Cortex Mori is the root bark of moraceae plants Mulberry, and main effect is eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.Semen Armeniacae Amarum is rosaceous plant Prunus armeniaca L.var.ansu Maxim., and the mature fruit of gathering summer, removes sarcocarp and nucleocapsid, takes out seed, dries.Attending effectiveness is sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.Bulbus Fritillariae Thunbergii is the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii, and effect is heat clearing away expelling phlegm for arresting cough, vanishing sputum and dispelling knot.Contained alkaloid has obvious antitussive effect.In addition also have the central inhibitory actions such as calmness, analgesia.Radix Glycyrrhizae is the root and rhizome of herbaceos perennial Radix Glycyrrhizae, and main effect is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Radix Polygalae is the dry root of milk wort Radix Polygalae and ovum leaf Radix Polygalae.Effect is the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminates the phlegm, and detumescence.The insomnia and dreamful sleep causing for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.The crude drug prescription of Chinese medicine composition of the present invention consists of Cortex Mori, Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae and Radix Polygalae, research worker of the present invention is preferentially tested according to test simultaneously, determine the prescription consumption of this traditional Chinese medicinal composition raw materials, make Chinese medicine composition reach the effect of effective eliminating phlegm and stopping cough.
Summary of the invention
Research worker of the present invention is by test, through a large amount of crude drug component screenings, finally determine and form prescription by Cortex Mori, Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae and Radix Polygalae Chinese medicine of the five flavours, simultaneously by optimization test, determined the significant crude drug prescription of this prescription pharmacological action amount ranges.
The crude drug prescription scope of this discovery Chinese medicine composition is Cortex Mori 60-120g, Semen Armeniacae Amarum 60-120g, Bulbus Fritillariae Thunbergii 80-160g, Radix Glycyrrhizae 10-20g, Radix Polygalae 30-60g.
Traditional Chinese medicinal composition raw materials prescription Chinese crude drug ratio of the present invention is Cortex Mori: Semen Armeniacae Amarum: Bulbus Fritillariae Thunbergii: Radix Glycyrrhizae: Radix Polygalae=6: 6: 8: 1: 3.
Chinese medicine composition of the present invention has the pharmacological action of eliminating phlegm and stopping cough.
The present invention is achieved through the following technical solutions:
The screening test of crude drug prescribed dose:
By Cortex Mori: Semen Armeniacae Amarum: Bulbus Fritillariae Thunbergii: Radix Glycyrrhizae: Radix Polygalae is tested as follows for the prescription ratio sequence design of screening:
(1) animal health Kunming mouse, male and female half and half, body weight 20 ± 2g.
(2) Chinese medicine composition configures according to different proportion, and each prescription decocts, filters, merging, concentrating under reduced pressure become extractum, standby.
1. cough-relieving test
Get Kunming mouse, be divided at random 2 groups, i.e. blank group, Chinese medicine composition group, 10 every group, according to corresponding dosed administration, last administration 1 hour, in desktop, injects cotton balls with syringe by 28% ammonia 2ml by 500ml beaker back-off, be placed in the beaker of back-off, after 30 seconds, take out cotton swab, put into respectively mice, observe the coughre flex of mice, record from put into mice to time of mice generation coughre flex be the cough number of times of cough latent period and 3 minutes mices.
2. the test of reducing phlegm
Get Kunming mouse, be divided at random 2 groups, i.e. blank group, Chinese medicine composition group, 10 every group, according to corresponding dosed administration, last administration, after 30 minutes, is only injected 1% phenol red liquid 0.25ml/ to mouse peritoneal.After 30 minutes, put to death mice, separated trachea, uses 5%NaHCO
3solution rinses trachea 3 times, each 0.5ml.Get flushing liquor 1ml, add dehydrated alcohol 2ml, shake up latter centrifugal 2 minutes, get supernatant and measure absorption value at 721 spectrophotometer 558nm places.
3. statistical method
Application SPSS13.0 software kit carries out statistical procedures.Mean ± standard deviation for data acquisition
represent, between group, relatively adopt variance analysis.
Table 1 different proportion prescription compages thing causes the impact of coughing mouse cough incubation period and cough number of times on strong aqua ammonia
Note: compare with blank group,
※p < 0.05,
※ ※p < 0.01.
Table 2 different proportion prescription compages thing is on the phenol red impact of mice trachea excretion
Note: compare with blank group,
※p < 0.05,
※ ※p < 0.01.
Result of the test shows, Chinese medicine composition group can extend mice ammonia draws and cough incubation period and reduce cough number of times, with the comparison of blank group, has significant difference, in Table 1.Meanwhile, Chinese medicine composition group all can promote that the excretion of mice trachea is phenol red, with the comparison of blank group, has significant difference, in Table 2.From result of the test, in prescribed dose ratio screening, when Cortex Mori: Semen Armeniacae Amarum: Bulbus Fritillariae Thunbergii: Radix Glycyrrhizae: Radix Polygalae=6: 6: 8: 1: in the time of 3, the pharmacological action of Chinese medicine composition is the most remarkable.
Preparation method test:
According to Cortex Mori: Semen Armeniacae Amarum: Bulbus Fritillariae Thunbergii: Radix Glycyrrhizae: Radix Polygalae=6: 6: 8: 1: 3 ratio takes medical material, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains drug extract.
Below according to Cortex Mori: Semen Armeniacae Amarum: Bulbus Fritillariae Thunbergii: Radix Glycyrrhizae: Radix Polygalae=6: 6: 8: 1: 3 ratio is carried out medicine configuration, extract 3 times, merge extractive liquid,, concentrating under reduced pressure, obtains extractum, with extractum, carries out following pharmacological testing:
1. animal
Healthy Kunming mouse, male and female half and half, body weight 20 ± 2g; Wistar rat, male and female half and half, body weight 260 ± 20g.
2. couple SO
2cause the impact of coughing mice
Get Kunming mouse, be divided at random two groups, i.e. blank group, Chinese medicine composition group, 10 every group, dosage is 4g/kg, and be administered once every day, and administration is 7 days altogether, and after last administration 1 hour, mice is put into the wide mouthed bottle of 500ml, pass into SO
26ml, draws and coughs altogether, observes and record the cough latent period of mice and the number of times of cough in 3 minutes, in Table 3.
Table 3 medicine is to SO
2cause the impact of coughing mouse cough incubation period and cough number of times
Note: compare with blank group,
※p < 0.05.
3. the impact on rat expectoration amount
Get Wistar rat, male and female half and half, are divided into two groups at random, i.e. blank group, and Chinese medicine composition group, 10 every group, dosage is 4g/kg, administration every day 1 time, administration is 7 days altogether.Before test, fasting be can't help water 12 hours, after last administration 30 minutes, with pentobarbital sodium 30mg/kg, anaesthetize, dorsal position is fixed, and cuts off neck center skin, separated trachea, among thyroid cartilage lower edge hits exactly two cartilaginous rings, with injection needle, prick an aperture, then insert one, the capillary tube of the known weight G1 of diameter 0.5ml, be about 10cm.Make capillary glass-tube just contact trachea portion surface, to absorb the sputum in trachea, if a glass-tube is filled, change a glass-tube at once, collect the rat expectoration amount of 60 minutes, then with electronic scale weighing, collect the weight G2 of the glass-tube of sputum, G2-G1 is the rat expectoration amount of 60 minutes, calculate the drain mg number of 60min/100g as the index of eliminating the phlegm, in Table 4.
The impact of table 4 on rat expectoration amount
Note: compare with blank group,
※ ※p < 0.01.
Result of the test shows, Chinese medicine composition of the present invention can extend mice SO
2draw and cough incubation period and reduce cough number of times, with the comparison of blank group, all p < 0.05, has significant difference; Chinese medicine composition of the present invention can promote the expectoration amount of rat, and with the comparison of blank group, p < 0.01, has significant difference.By the observation to test, Chinese medicine composition of the present invention is to strong aqua ammonia, SO
2cause incubation period and cough number of times and the impact on the phenol red excretion amount of mice trachea, Hair of Rat glass tubing expectoration amount of coughing mice, result shows, the effect that Chinese medicine composition of the present invention has cough-relieving, reduces phlegm.
The specific embodiment
Embodiment 1
Take Cortex Mori 60g, Semen Armeniacae Amarum 60g, Bulbus Fritillariae Thunbergii 80g, Radix Glycyrrhizae 10g, Radix Polygalae 30g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 2
Take Cortex Mori 120g, Semen Armeniacae Amarum 120g, Bulbus Fritillariae Thunbergii 160g, Radix Glycyrrhizae 20g, Radix Polygalae 60g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 3
Take Cortex Mori 60g, Semen Armeniacae Amarum 70g, Bulbus Fritillariae Thunbergii 80g, Radix Glycyrrhizae 20g, Radix Polygalae 60g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 4
Take Cortex Mori 70g, Semen Armeniacae Amarum 80g, Bulbus Fritillariae Thunbergii 90g, Radix Glycyrrhizae 10g, Radix Polygalae 50g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 5
Take Cortex Mori 80g, Semen Armeniacae Amarum 90g, Bulbus Fritillariae Thunbergii 100g, Radix Glycyrrhizae 20g, Radix Polygalae 60g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 6
Take Cortex Mori 90g, Semen Armeniacae Amarum 100g, Bulbus Fritillariae Thunbergii 110g, Radix Glycyrrhizae 10g, Radix Polygalae 40g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 7
Take Cortex Mori 100g, Semen Armeniacae Amarum 110g, Bulbus Fritillariae Thunbergii 120g, Radix Glycyrrhizae 15g, Radix Polygalae 60g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 8
Take Cortex Mori 90g, Semen Armeniacae Amarum 90g, Bulbus Fritillariae Thunbergii 120g, Radix Glycyrrhizae 15g, Radix Polygalae 45g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 9
Take Cortex Mori 110g, Semen Armeniacae Amarum 120g, Bulbus Fritillariae Thunbergii 130g, Radix Glycyrrhizae 20g, Radix Polygalae 30g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 10
Take Cortex Mori 120g, Semen Armeniacae Amarum 120g, Bulbus Fritillariae Thunbergii 140g, Radix Glycyrrhizae 10g, Radix Polygalae 60g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 11
Take Cortex Mori 120g, Semen Armeniacae Amarum 120g, Bulbus Fritillariae Thunbergii 140g, Radix Glycyrrhizae 10g, Radix Polygalae 60g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 12
Take Cortex Mori 120g, Semen Armeniacae Amarum 120g, Bulbus Fritillariae Thunbergii 150g, Radix Glycyrrhizae 15g, Radix Polygalae 35g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 13
Take Cortex Mori 110g, Semen Armeniacae Amarum 100g, Bulbus Fritillariae Thunbergii 160g, Radix Glycyrrhizae 15g, Radix Polygalae 55g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 14
Take Cortex Mori 100g, Semen Armeniacae Amarum 120g, Bulbus Fritillariae Thunbergii 130g, Radix Glycyrrhizae 10g, Radix Polygalae 45g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Embodiment 15
Take Cortex Mori 105g, Semen Armeniacae Amarum 125g, Bulbus Fritillariae Thunbergii 145g, Radix Glycyrrhizae 15g, Radix Polygalae 35g, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
Claims (5)
1. treat a Chinese medicine composition for eliminating phlegm and stopping cough, its crude drug consists of Cortex Mori 60-120g, Semen Armeniacae Amarum 60-120g, Bulbus Fritillariae Thunbergii 80-160g, Radix Glycyrrhizae 10-20g, Radix Polygalae 30-60g.
2. Chinese medicine composition as claimed in claim 1, crude drug forms and is preferably Cortex Mori: Semen Armeniacae Amarum: Bulbus Fritillariae Thunbergii: Radix Glycyrrhizae: Radix Polygalae=6: 6: 8: 1: 3.
3. Chinese medicine composition as claimed in claim 2, its preparation method comprises the steps: according to Cortex Mori: Semen Armeniacae Amarum: Bulbus Fritillariae Thunbergii: Radix Glycyrrhizae: Radix Polygalae=6: 6: 8: 1: 3 ratio takes medical material, decoct with water 3 times, amount of water is 10 times of medical material total amount for the first time, decocts 2 hours; For the second time and for the third time amount of water is 8 times of medical material total amount, decocts 1 hour, merges the decocting liquid of three times, filters, and obtains filtrate, is evaporated to every milliliter contained 3g, obtains compositions extractum.
4. a Chinese medicine composition for the treatment of eliminating phlegm and stopping cough, is mainly used in antitussive action.
5. a Chinese medicine composition for the treatment of eliminating phlegm and stopping cough, is mainly used in phlegm-dispelling functions.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596219A (en) * | 2017-09-07 | 2018-01-19 | 成都兴倍加生物科技有限责任公司 | A kind of new medicine composition for cough-relieving apophlegmatic and preparation method thereof |
| CN115089657A (en) * | 2022-08-03 | 2022-09-23 | 许田 | Traditional Chinese medicine composition for treating atopic dermatitis, preparation method and application thereof |
-
2013
- 2013-10-15 CN CN201310480018.1A patent/CN103610897A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596219A (en) * | 2017-09-07 | 2018-01-19 | 成都兴倍加生物科技有限责任公司 | A kind of new medicine composition for cough-relieving apophlegmatic and preparation method thereof |
| CN115089657A (en) * | 2022-08-03 | 2022-09-23 | 许田 | Traditional Chinese medicine composition for treating atopic dermatitis, preparation method and application thereof |
| CN115089657B (en) * | 2022-08-03 | 2023-09-15 | 许田 | Traditional Chinese medicine composition for treating atopic dermatitis, preparation method and application thereof |
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