CN1036009C - 2-噻吩基咪唑并[2，1-b]苯并噻唑-3-乙酸衍生物，其制备方法及其药用 - Google Patents

2-噻吩基咪唑并[2，1-b]苯并噻唑-3-乙酸衍生物，其制备方法及其药用 Download PDF

Info

Publication number
CN1036009C
CN1036009C CN93121519A CN93121519A CN1036009C CN 1036009 C CN1036009 C CN 1036009C CN 93121519 A CN93121519 A CN 93121519A CN 93121519 A CN93121519 A CN 93121519A CN 1036009 C CN1036009 C CN 1036009C
Authority
CN
China
Prior art keywords
formula
benzothiazole
compound
imidazo
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93121519A
Other languages
English (en)
Chinese (zh)
Other versions
CN1096029A (zh
Inventor
M·塞夫林
C·莫雷尔
M·曼加尼
P·乔治
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SYNTHETIC LABORATORY CORP
Synthelabo SA
Original Assignee
SYNTHETIC LABORATORY CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SYNTHETIC LABORATORY CORP filed Critical SYNTHETIC LABORATORY CORP
Publication of CN1096029A publication Critical patent/CN1096029A/zh
Application granted granted Critical
Publication of CN1036009C publication Critical patent/CN1036009C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Weting (AREA)
  • Diffracting Gratings Or Hologram Optical Elements (AREA)
CN93121519A 1992-12-30 1993-12-29 2-噻吩基咪唑并[2，1-b]苯并噻唑-3-乙酸衍生物，其制备方法及其药用 Expired - Fee Related CN1036009C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9215889 1992-12-30
FR9215889A FR2699921B1 (fr) 1992-12-30 1992-12-30 Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.

Publications (2)

Publication Number Publication Date
CN1096029A CN1096029A (zh) 1994-12-07
CN1036009C true CN1036009C (zh) 1997-10-01

Family

ID=9437257

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93121519A Expired - Fee Related CN1036009C (zh) 1992-12-30 1993-12-29 2-噻吩基咪唑并[2，1-b]苯并噻唑-3-乙酸衍生物，其制备方法及其药用

Country Status (18)

Country Link
US (1) US5418248A (en, 2012)
EP (1) EP0605295A1 (en, 2012)
JP (1) JPH06234770A (en, 2012)
KR (1) KR0140846B1 (en, 2012)
CN (1) CN1036009C (en, 2012)
AU (1) AU666790B2 (en, 2012)
CA (1) CA2112555A1 (en, 2012)
CZ (1) CZ282959B6 (en, 2012)
FI (1) FI935915A7 (en, 2012)
FR (1) FR2699921B1 (en, 2012)
HU (1) HUT70409A (en, 2012)
IL (1) IL108225A (en, 2012)
NO (1) NO934881L (en, 2012)
NZ (1) NZ250579A (en, 2012)
PL (1) PL301680A1 (en, 2012)
SK (1) SK149393A3 (en, 2012)
TW (1) TW257764B (en, 2012)
ZA (1) ZA939760B (en, 2012)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006724A1 (fr) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Agonistes du recepteur du glutamate metabotropique
EP2218464A1 (en) * 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895863A (en) * 1987-10-20 1990-01-23 Roussel Uclaf Novel imidazo[2,1-B]benzothiazoles
US4968708A (en) * 1988-06-22 1990-11-06 Nikken Chemicals Co., Ltd. Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4896863A (en) * 1988-05-26 1990-01-30 Tim Riplinger System having material dispensing and wind up device with guide
EP0524055A1 (fr) * 1991-07-19 1993-01-20 Synthelabo Dérivés d'imidazo[2,1-b]benzothiazole-3-acétamide, leur préparation et leur application en thérapeutique
PT884319E (pt) * 1992-03-12 2004-09-30 Smithkline Beecham Plc N-¬(1-n-butil-4-piperidil)metil|-3,4-di-hidro-2h-¬1,3|oxazino¬3,2-a|indole-10-carboxamida ou um seu sal farmaceuticamente aceitavel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895863A (en) * 1987-10-20 1990-01-23 Roussel Uclaf Novel imidazo[2,1-B]benzothiazoles
US4968708A (en) * 1988-06-22 1990-11-06 Nikken Chemicals Co., Ltd. Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same

Also Published As

Publication number Publication date
ZA939760B (en) 1994-08-18
IL108225A0 (en) 1994-04-12
FR2699921B1 (fr) 1995-02-10
US5418248A (en) 1995-05-23
FI935915L (fi) 1994-07-01
NZ250579A (en) 1995-07-26
CZ291893A3 (en) 1994-07-13
CN1096029A (zh) 1994-12-07
EP0605295A1 (fr) 1994-07-06
JPH06234770A (ja) 1994-08-23
IL108225A (en) 1997-04-15
FI935915A0 (fi) 1993-12-29
KR0140846B1 (ko) 1998-06-15
HU9303785D0 (en) 1994-04-28
NO934881D0 (no) 1993-12-29
HUT70409A (en) 1995-10-30
TW257764B (en, 2012) 1995-09-21
FI935915A7 (fi) 1994-07-01
CA2112555A1 (en) 1994-07-01
NO934881L (no) 1994-07-01
PL301680A1 (en) 1994-07-11
AU5276293A (en) 1994-07-14
AU666790B2 (en) 1996-02-22
SK149393A3 (en) 1995-02-08
CZ282959B6 (cs) 1997-11-12
KR940014415A (ko) 1994-07-18
FR2699921A1 (fr) 1994-07-01

Similar Documents

Publication Publication Date Title
EP2459565B1 (en) Saxitoxin derivatives, methods and compositions for studying, imaging, and treating pain
CN101827848B (zh) 作为IGF-1R抑制剂用于治疗癌症的2-[(2-{苯基氨基}-1H-吡咯并[2,3-d]嘧啶-4-基)氨基]苯甲酰胺衍生物
CN1187367C (zh) 具有麻醉剂活性的3α－羟基－3β－甲氧基甲基－21－杂环取代的类固醇
CN1052005C (zh) 咪唑并吡啶、其制法和药用
CN101072779B (zh) 2,4(4,6)嘧啶衍生物
CN1083448C (zh) 1-苯基-4-苄基哌嗪化合物多巴胺受体亚型的特异性配体(d4)
CN101796053A (zh) 用作食欲素受体拮抗剂的哌啶衍生物
CN1440292A (zh) 吡啶并[2,3－d]嘧啶和嘧啶并[4,5－d]嘧啶核苷
CN105189484A (zh) Cxcr7拮抗剂
WO1999028320A1 (fr) Derives de 2-aryl-8-oxodihydropurine, procede de production de ces derives, compositions medicales contenant ces derives, et intermediaires de ces derives
JP2010531849A (ja) オレキシン受容体アンタゴニストとしてのイミダゾ［１，２−ｃ］ピリミジン−２−イルメチルピペリジン誘導体
CN1069643C (zh) 抑制巨细胞病毒的二氮杂萘及其类似物
BR112012009310B1 (pt) composto derivados de 2-oxo-1-pirrolidinil imidazotiadiazol, uso dos mesmos e composição farmacêutica compreendendo os mesmos
CN1844096A (zh) 一种米格列奈钙的制备及质量控制方法
CN86103615A (zh) 尿嘧啶衍生物转化成胞嘧啶衍生物的方法
KR20240128987A (ko) Flt3의 억제제로서의 피라진 화합물
CN1140174A (zh) 哌啶衍生物，它们的制备方法及其在治疗中的应用
HUE026889T2 (en) 2-Oxo-1-imidazolidinyl derivatives imidazotiadiazol
CN1034575C (zh) 选择性腺苷受体剂的制备方法
CN1036009C (zh) 2-噻吩基咪唑并[2，1-b]苯并噻唑-3-乙酸衍生物，其制备方法及其药用
CN1313766A (zh) 新的切割dna的抗肿瘤剂
CN1199338A (zh) 作为多巴胺受体的配体的新的稠合异喹啉
CN104109143A (zh) 一类褪黑激素(mt1-mt2)受体激动剂及其制备方法与用途
CN1393446A (zh) 稠合吡唑化合物
CN1083476A (zh) 喹啉衍生物的富马酸盐

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee