CN103565698B - Alpinia nutaus extract with activity of fighting against senium and its preparation method and application - Google Patents
Alpinia nutaus extract with activity of fighting against senium and its preparation method and application Download PDFInfo
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- CN103565698B CN103565698B CN201310557274.6A CN201310557274A CN103565698B CN 103565698 B CN103565698 B CN 103565698B CN 201310557274 A CN201310557274 A CN 201310557274A CN 103565698 B CN103565698 B CN 103565698B
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Abstract
The invention discloses a kind of Alpinia nutaus extract with activity of fighting against senium and its preparation method and application, comprise following steps: (1) adopts volumetric concentration to be that the methanol solution of 45-55% is to the Alpinia nutaus powder reflux, extract, after oven dry, filter to obtain supernatant, repeat aforesaid operations 2-3 time; (2) mixed by step (1) gained supernatant, adopt normal butane extraction, extract adopts vacuum concentration, obtains paste; (3) at the temperature of 25-35 DEG C, deionized water is added in described paste, dissolve, filter, collect filtrate, vacuum concentration, dry, to obtain final product.The Alpinia nutaus extract working substance content that preparation method of the present invention obtains is high, and stable performance, can be added in multiple skin-protection product, play senile-resistant efficacy.
Description
Technical field
The present invention relates to cosmetic field, particularly relate to a kind of Alpinia nutaus extract with activity of fighting against senium and its preparation method and application.
Background technology
Aging is the inexorable law of any biological life process, and along with becoming increasingly conspicuous of the problem of an aging population in world wide, defying age field has become the focus of global concern.The one of the main reasons of skin aging is that the structure of skin corium there occurs change.The reason of dermis of skin structural change is caused to have a variety of, wherein, due to some extraneous factor effects, swash intravital matrix metalloproteinase (MMPs), collagen protein and the elastin laminin that can cause supporting in dermis of skin skin texture are excessively degraded, thus make skin occur shrinkage, the senile symptom such as nonelastic.Secondly, with advancing age, interior free yl is too much, and the ability that human body repairs free radical declines thereupon, causes cell damage.Or outside environmental elements such as ionizing radiation, oxidative environment, pollution etc. often can induce generation and the accumulation of abnormal free radical; and the accumulation of a large amount of free radical; then will produce random damage to many biomacromolecules and cell; thus cause apoptosis; and then making skin occur wrinkle, drying is nonelastic waits senile symptom.
In order to resist aging, people maintain the form of skin usually by several method.1, sheep placental extract isoreactivity material is injected.This kind of method energy reduce wrinkle fast, reaches the effect that people pursue the youth fast.But this method exists the problem of somewhat expensive, have side effects in addition and cause the risk of skin allergy, abscess.2, make to apply some make up.A lot of cosmetics declare to have anti crease and anti senile prepared old effect on the market, but a lot of cosmetics employ the raw material of a large amount of chemosynthesis, and there is zest, its safety is also still to be tested.
Alpinia nutaus, another name shellflower, is under the jurisdiction of Zingiberaceae Rhizoma Zingiberis Recens subfamily Rhizoma Zingiberis Recens race Alpinia shellflower subgenus.Be distributed widely in China southeast to various places, the west and south.Main chemical compositions is the compound such as volatile oil, flavonoid (as Alpinetin, rutin).
Alpinetin
Molecular formula: C
16h
14o
4;
Molecular weight: 270.27996;
Chemical classification: Flavonoids flavonoid;
Pharmacological action: have the effect such as antibacterial, antioxidation, anticancer, antithrombotic, blood pressure lowering, blood fat reducing, blood sugar lowering, emesis, analgesia.
Rutin
Molecular formula: C
27h
30o
16;
Molecular weight: 610.51;
Chemical classification: Flavonoids flavonoid.
Rutin has extremely strong Absorption to ultraviolet and X-ray, and as natural sun-screening agents, add the rutin of 10%, ultraviolet absorbance is up to 98%.Rutin can clearly scavenger cell produce reactive oxygen free radical, and to the clearance rate of Oi (ultra-oxygen anion free radical) up to 78.1%, be far longer than the effect of vitamin E (12.7%), and to OH(hydroxyl radical free radical) scavenging action be also greater than vitamin E.
At present Alpinia nutaus research is mainly concentrated on component and effect, all corresponding record is not retrieved to Alpinia nutaus extracting method or patent application.
Summary of the invention
Based on this, be necessary for the problems referred to above, Alpinia nutaus extract with activity of fighting against senium that a kind of working substance content is high and its preparation method and application is provided.
For realizing above-mentioned technical purpose, concrete scheme is as follows:
There is a preparation method for the Alpinia nutaus extract of activity of fighting against senium, comprise following steps:
(1) adopt volumetric concentration be the methanol solution of 45-55% to the Alpinia nutaus powder reflux, extract, after drying, filter to obtain supernatant, repeat aforesaid operations 2-3 time;
(2) mixed by step (1) gained supernatant, adopt normal butane extraction, extract adopts vacuum concentration, obtains paste;
(3) at the temperature of 25-35 DEG C, deionized water is added in described paste, dissolve, filter, collect filtrate, vacuum concentration, dry, to obtain final product; Described Alpinia nutaus powder be by the moon peach seeds, one or both pulverizing in moon Folium Persicae form.The dissolving using ultrasonic generator of above-mentioned paste, can the process of accelerate dissolution, improves dissolved efficiency.
Wherein in some embodiments, described Alpinia nutaus powder be by weight ratio be 1-3:1 the moon peach seeds and the moon Folium Persicae pulverize form.
Wherein in some embodiments, the weight of described methanol solution is 2-10 times of described Alpinia nutaus powder; The weight of described normal butane is 2-5 times of described supernatant; The weight of described deionized water is described paste 2-5 times.
Wherein in some embodiments, described Alpinia nutaus powder is 30-40 order.
Wherein in some embodiments, in described step (1), the parameter of reflux, extract, process is extract 4-8 hour at the temperature of 60-70 DEG C.
Present invention also offers the Alpinia nutaus extract with activity of fighting against senium obtained by above-mentioned preparation method.
Present invention also offers the above-mentioned Alpinia nutaus extract with activity of fighting against senium and prepare the application in cosmetics.
Wherein in some embodiments, described State of cosmetics comprises cream frost, emulsion, water preparation.
Present invention also offers a kind of cosmetics, it includes the Alpinia nutaus extract foregoing with activity of fighting against senium.
Present invention also offers a kind of skin cream, include the component of following percentage by weight: the Alpinia nutaus extract foregoing with activity of fighting against senium: 1.8-2.2%; Aliphatic acid polyethenoxy ether glucoside: 1.6-2.0%; Glyceryl stearate/PEG-100 stearate: 1.3-1.7%; Cetearyl alcohol: 1.8-2.2%; Caprylic/capric triglyceride: 2.8-3.2%; Isopropyl myristate: 2.8-3.2%; Squalane: 1.8-2.2%; Butyrospermum Parkii Oil: 0.4-0.6%; HANSHENGJIAO: 0.1-0.2%; Glycerol: 5-7%; Polyacrylamide/C13-14 isoparaffin/Alpinia nutaus alcohol polyethers-7:0.1-0.2%; Phenoxyethanol/Sensiva SC50: 0.5-0.6%; Deionized water: surplus.
The present invention relative to the advantage of prior art and beneficial effect is:
The present invention is by the great many of experiments of inventor and the preferred various conditions of preparation method of experience, obtain the preparation method of optimization, adopt the Alpinia nutaus extract that preparation method of the present invention obtains, working substance content is high, properties of product are stablized, can be added in multiple skin-protection product, as cream frost, emulsion, water preparation etc.The present invention can improve SOD activity, removes DPPH free radical, plays antioxidation, can enter skin corium, promotes the synthesis of collagen protein, recovers the elasticity of skin, reduces the generation of microgroove, plays antidotal effect.
Detailed description of the invention
The following Components Name occurred in embodiment is INCI(InternationalNomenclatureCosmeticIngredient, i.e. international cosmetic raw material name) title of defined: glyceryl stearate/PEG-100 stearate, caprylic/capric triglyceride, polyacrylamide/C13-14 isoparaffin/Alpinia nutaus alcohol polyethers-7, phenoxyethanol/Sensiva SC50.
Embodiment 1
There is a preparation method for the Alpinia nutaus extract of activity of fighting against senium, comprise following steps:
(1) collect the fresh moon Folium Persicae and the moon peach seeds, ovendry power is broken to 40 orders respectively, by weight 2:1 mixing, obtained Alpinia nutaus powder;
(2) adopt volumetric concentration be 50% methanol solution at the temperature of 60 DEG C, 7 hours reflux extractions are carried out to Alpinia nutaus powder, filter to obtain supernatant, repeat aforesaid operations 3 times, the weight of wherein said methanol solution is 10 times of described Alpinia nutaus powder;
(3) mixed by step (2) gained supernatant, adopt normal butane extraction, extract adopts vacuum concentration to 1/2 of described supernatant weight, and obtain paste, the weight of wherein said normal butane is 5 times of described supernatant;
(4) at the temperature of 30 DEG C, deionized water is added in described paste, put into supersonic generator and dissolve, filter, collect filtrate, be concentrated in vacuo to volume when being reduced to 1/3, dry, obtain, the weight of wherein said deionized water is described paste 5 times.
The Alpinia nutaus extract with activity of fighting against senium of embodiment 1 gained is applied in skin cream, specific as follows:
Preparation technology:
1, A heat phase to 80 DEG C is dissolved, for subsequent use;
2, by B heat phase to 80 DEG C, homogenizing 2 minutes;
3, A is added to B phase, is incubated 75 DEG C and stirs 30 minutes;
4, after temperature is down to 65 DEG C, add C phase, stir;
5, D phase is dissolved in advance;
6, after temperature is down to 45 DEG C, add D phase, stir;
7, after D phase stirs, add E phase, stir 10 minutes.
Adopt the skin cream prepared by embodiment 1, through 40 ages be 30-40 year and the darker women of face's colour of skin after 30 days on probation (every day sooner or later each use 1 time), have 39 trier's facial skins obviously to polish, compact, microgroove obviously reduces, and face moistens flexible.There is 1 trier's facial skin without significant change.Result is used to show that the skin cream being added with Alpinia nutaus extract prepared by embodiment 1 has good anti-aging effects.
Embodiment 2
There is a preparation method for the Alpinia nutaus extract of activity of fighting against senium, comprise following steps:
(1) collect fresh moon Folium Persicae, dry, be crushed to 30 orders;
(2) adopt volumetric concentration be 45% methanol solution at the temperature of 65 DEG C, 8 hours reflux extractions are carried out to moon Folium Persicae powder, filter to obtain supernatant, repeat aforesaid operations 2 times, the weight of wherein said methanol solution is 2 times of described Alpinia nutaus powder;
(3) mixed by step (2) gained supernatant, adopt normal butane extraction, extract adopts vacuum concentration to 1/2 of described supernatant weight, and obtain paste, the weight of wherein said normal butane is 2 times of described supernatant;
(4) at the temperature of 25 DEG C, deionized water is added in described paste, put into supersonic generator and dissolve, filter, collect filtrate, be concentrated in vacuo to volume when being reduced to 1/3, dry, obtain, the weight of wherein said deionized water is 2 times of described paste.
Embodiment 3
There is a preparation method for the Alpinia nutaus extract of activity of fighting against senium, comprise following steps:
(1) collect fresh moon peach seeds, dry, be crushed to 35 orders;
(2) adopt volumetric concentration be 55% methanol solution at the temperature of 70 DEG C, 4 hours reflux extractions are carried out to Alpinia nutaus seed powder, filter to obtain supernatant, repeat aforesaid operations 3 times, the weight of wherein said methanol solution is 5 times of described Alpinia nutaus seed powder;
(3) mixed by step (2) gained supernatant, adopt normal butane extraction, extract adopts vacuum concentration to 1/2 of described supernatant weight, and obtain paste, the weight of wherein said normal butane is 3.5 times of described supernatant;
(4) at the temperature of 35 DEG C, deionized water is added in described paste, put into supersonic generator and dissolve, filter, collect filtrate, be concentrated in vacuo to volume when being reduced to 1/3, dry, obtain, the weight of wherein said deionized water is 3.5 times of described paste.
Comparative example 1
A preparation method for Alpinia nutaus extract, comprises following steps:
(1) collect the fresh moon Folium Persicae and the moon peach seeds, dry respectively and be crushed to 20 orders, mixing by the weight ratio of 1:1, obtained Alpinia nutaus powder;
(2) adopt volumetric concentration be 70% methanol solution 9 hours reflux extractions are carried out at 50 DEG C to Alpinia nutaus powder, filter to obtain supernatant, repeat aforesaid operations 4 times, the weight of described methanol solution is 12 times of described Alpinia nutaus powder;
(3) mixed by step (2) gained supernatant, adopt normal butane extraction, extract adopts vacuum concentration to 1/2 of described supernatant weight, and obtain paste, the weight of described normal butane is 8 times of described supernatant;
(4) added in described paste by deionized water at 40 DEG C, put into supersonic generator and dissolve, filter, collect filtrate, be concentrated in vacuo to volume when being reduced to 1/3, dry, obtaining final product, the weight of wherein said deionized water is 8 times of described paste.
Comparative example 2
Comparative example 2 is a kind of preparation method of Alpinia nutaus extract, the alcoholic solution being 50% except employing volumetric concentration in step (2) extracts Alpinia nutaus powder, and employing volumetric concentration is the alcoholic solution extraction supernatant of 50% in step (3), all the other processing steps are identical with embodiment 1 with parameter.
The general flavone content of Alpinia nutaus extract in embodiment 1-3 and comparative example 1,2:
In Alpinia nutaus extract, antidotal main active is Alpinetin and rutin, both flavone compounds, this experiment measures the general flavone content of Alpinia nutaus extract in each embodiment and comparative example according to " wild Dendrocalamus giganteus Munro Folium Bambosae flavone content and Antioxidative Activity Determination experiment thereof " method that [western forest-science] the 42nd volume the 2nd is interim, show that the Alpinia nutaus extract flavone content that embodiment 1 obtains is 9.67 ‰, the Alpinia nutaus extract flavone content that embodiment 2 obtains is 7.51 ‰, the Alpinia nutaus extract flavone content that embodiment 3 obtains is 6.21 ‰, the Alpinia nutaus extract flavone content that comparative example 1 obtains is 2.20 ‰, the Alpinia nutaus extract flavone content that comparative example 2 obtains is 1.85 ‰.As can be seen from data result, the Alpinia nutaus extract flavone content that the Alpinia nutaus extract flavone content that embodiment 1,2,3 obtains obtains apparently higher than comparative example 1,2.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (6)
1. there is a preparation method for the Alpinia nutaus extract of activity of fighting against senium, it is characterized in that, comprise following steps:
(1) adopt volumetric concentration be the methanol solution of 45-55% to the Alpinia nutaus powder reflux, extract, after drying, filter to obtain supernatant, repeat aforesaid operations 2-3 time;
(2) mixed by step (1) gained supernatant, adopt normal butane extraction, extract adopts vacuum concentration, obtains paste;
(3) at the temperature of 25-35 DEG C, deionized water is added in described paste, dissolve, filter, collect filtrate, vacuum concentration, dry, to obtain final product;
Described Alpinia nutaus powder be by weight ratio be 1-3:1 the moon peach seeds and the moon Folium Persicae pulverize form;
Described Alpinia nutaus powder is 30-40 order;
The weight of described methanol solution is 2-10 times of described Alpinia nutaus powder; The weight of described normal butane is 2-5 times of described supernatant; The weight of described deionized water is described paste 2-5 times;
In described step (1), the parameter of reflux, extract, process is extract 4-8 hour at the temperature of 60-70 DEG C.
2. the Alpinia nutaus extract with activity of fighting against senium according to claim 1 obtained by preparation method.
3. the Alpinia nutaus extract with activity of fighting against senium according to claim 2 is preparing the application in cosmetics.
4. the Alpinia nutaus extract with activity of fighting against senium according to claim 3 is preparing the application in cosmetics, and it is characterized in that, described State of cosmetics comprises cream frost, emulsion, water preparation.
5. cosmetics, is characterized in that, include the Alpinia nutaus extract with activity of fighting against senium according to claim 2.
6. a skin cream, is characterized in that, is made up of the component of following percentage by weight: the Alpinia nutaus extract with activity of fighting against senium according to claim 2: 1.8-2.2%; Aliphatic acid polyethenoxy ether glucoside: 1.6-2.0%; Glyceryl stearate/PEG-100 stearate: 1.3-1.7%; Cetearyl alcohol: 1.8-2.2%; Caprylic/capric triglyceride: 2.8-3.2%; Isopropyl myristate: 2.8-3.2%; Squalane: 1.8-2.2%; Butyrospermum Parkii Oil: 0.4-0.6%; HANSHENGJIAO: 0.1-0.2%; Glycerol: 5-7%; Polyacrylamide/C13-14 isoparaffin/Alpinia nutaus alcohol polyethers-7:0.1-0.2%; Phenoxyethanol/Sensiva SC50: 0.5-0.6%; Deionized water: surplus.
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| CN114191519A (en) * | 2021-12-10 | 2022-03-18 | 佛山市连艺生物科技有限公司 | Application of alpinia japonica alcohol extract in preparation of ultraviolet light aging resistant medicine |
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| 生物类黄酮的研究与应用综述;陈春刚等;《安徽农业科学》;20061231;第34卷(第13期);2949-2951 * |
| 艳山姜叶的生物活性;怡悦;《国外医学 中医中药分册》;20021231;第24卷(第05期);313 * |
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