CN103550514B - 一种治疗慢性反流性肾病的中药 - Google Patents
一种治疗慢性反流性肾病的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗慢性反流性肾病的中药，由以下重量配比的药材制备而成：毛连14份、手参12份、水茄10份、金鸡脚10份、刺芫荽8份、骆驼蓬8份、假茶辣12份、猪肚子14份、崖姜14份、凤眼草16份、南天仙子12份、素馨花10份、鸡脚参14份、惊风草12份、一匹草10份、叶下珠14份。临床实验证明，本发明能够安全有效治疗慢性反流性肾病。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗慢性反流性肾病的中药。
背景技术
慢性反流性肾病(chronicrefluxnephropathy)，以往称为“慢性萎缩性肾盂肾炎”，是间质性肾病的一种。以肾表面的不规则粗大瘢痕、受累肾盏杵状肥大和扩张变形、受累皮质萎陷退缩、膀胱输尿管反流(VUR)为特征。在探测到瘢痕时VUR可能不明确，或VUR已经消失。部分病例的特征是反复尿路感染(UTI)，由于瘢痕形成的程度不同，肾损害可为局限性和弥漫性。慢性反流性肾病的病因是膀胱输尿管反流。膀胱输尿管反流是尿液通过不健全的膀胱输尿管连接处的反流生理情况下，输尿管最后一段的活瓣机制的解剖功能完整性能防止这种反流。
但是对于慢性反流性肾病目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
毛连【来源】毛茛科侧金盏花属植物四川侧金盏，以全草入药。夏季采收，洗净，阴干。【功能主治】清热燥湿，镇静。用于痈肿疮毒，目赤肿痛，呕吐泻痢，心悸不眠，癫痫。
手参【来源】为兰科手参属植物手参的块根。秋季采挖，去茎叶及须根，洗净，放入开水锅内煮至无心白为度，捞出晒干。【功能主治】补肾益精，理气止痛。病后体弱，神经衰弱，咳嗽，阳痿，久泻，白带，跌打损伤，淤血肿痛。
水茄【来源】茄科茄属植物水茄，以根入药。全年可采，洗净晒干。【功能主治】散瘀，通经，消肿，止痛，止咳。根：用于跌打瘀痛，腰肌劳损，胃痛，牙痛，闭经，久咳。鲜叶：捣烂外敷可治无名肿毒。
金鸡脚【来源】水龙骨科假密网蕨属植物金鸡脚，以全草入药。夏秋采收，洗净鲜用或晒干。【功能主治】祛风清热，利湿解毒。用于小儿惊风，感冒咳嗽，小儿支气管肺炎，咽喉肿痛，扁桃体炎，中暑腹痛，痢疾，腹泻，泌尿系感染，筋骨疼痛；外用治痈疖，疔疮，毒蛇咬伤。
刺芫荽【来源】伞形科刺芫荽属植物刺芫荽，以全草入药。夏秋采，阴干或鲜用。【功能主治】疏风解热，健胃。用于感冒，麻疹内陷，气管炎，肠炎，腹泻，急性传染性肝炎；外用治跌打肿痛。
骆驼蓬【来源】蒺藜科骆驼蓬属植物骆驼蓬PeganumharmalaL.，以全草及种子入药。夏秋采全草，种子成熟时采，晒干或鲜用。【功能主治】宣肺止咳，祛风湿，解毒。子：咳嗽气喘。全草：外用治无名肿毒，风湿性关节炎。
假茶辣【来源】楝科浆果楝属植物灰毛浆果楝.，以根、叶入药。根全年可采，切片晒干。叶夏秋采，鲜用或阴干。【功能主治】清热解毒，行气通便，截疟。用于感冒，发热不退，疟疾，大便秘结，腹痛，痢疾，风湿关节痛；外用治小儿皮炎，皮肤瘙痒，烧烫伤。
猪肚子【来源】菊科蟹甲草属植物羽裂蟹甲草以地下块茎入药。秋末苗枯后采挖，洗净晒干。【功能主治】祛风，化痰，平肝。用于头痛眩晕，风湿疼痛，偏瘫，咳嗽痰多。
崖姜【来源】蕨类水龙骨科崖姜属植物崖姜，以根状茎入药。春夏采集，去毛，洗净切片，晒干。【功能主治】祛风除湿，舒筋活络。用于风湿疼痛，跌打损伤，骨折，中耳炎。
凤眼草【来源】本品为苦木科植物臭椿的果实。秋末采果，晒干。【功能主治】清热利尿，止痛，止血。用于胃痛，便血，尿血；外用治阴道滴虫。
南天仙子【来源】爵床科水蓑衣属植物岩水蓑衣的种子。【功能主治】镇痉止痛。用于癫狂，抽搐，哮喘，胃痛。外用治痈肿，恶疮。
素馨花【来源】木犀科茉莉花属植物素馨花.以全株入药。全年可采，晒干或鲜用。【功能主治】行气调经止痛，清热散结。用于胃痛，肝炎，月经不调，痛经，带下，口腔炎，皮肤搔痒，睾丸炎，乳腺炎，淋巴结结核。
鸡脚参【来源】唇形科鸡脚参属植物鸡脚参，以根入药。夏秋采收，洗净晒干。【功能主治】祛风利尿，镇痛化积，接骨生肌。用于食积，脉管炎，肾炎，膀胱炎，尿路结石，风湿痛；外用治跌打损伤，骨折。
惊风草【来源】毛茛科白蓬草属植物惊风草的全草。夏秋采集，洗净晒干。【功能主治】清热解毒，定惊，消积。用于小儿肺炎，小儿惊风，小儿疳积。
一匹草【来源】兰科卷瓣兰属植物梳帽卷瓣兰CirrhopetalnmandersoniiHook.f.，以全草入药。四季可采，鲜用或晒干。【功能主治】祛风除湿，活血，止咳，消食积。用于跌打损伤，妇女体虚，小儿咳嗽，百日咳。
叶下珠【来源】为大戟科油柑属植物叶下珠PhyllanthusurinariaL.，以全草入药。夏秋采集全草，去杂质，晒干。【功能主治】清热利尿，明目，消积。用于肾炎水肿，泌尿系感染、结石，肠炎，痢疾，小二疳积，眼角膜炎，黄疸型肝炎；外用治青竹蛇咬伤。
发明内容
本发明旨在提供一种治疗慢性反流性肾病的中药，通过选择合适的药材及其配比，达到安全有效治愈慢性反流性肾病的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗慢性反流性肾病的中药，其特征在于，由以下重量配比的药材制备而成：毛连14份、手参12份、水茄10份、金鸡脚10份、刺芫荽8份、骆驼蓬8份、假茶辣12份、猪肚子14份、崖姜14份、凤眼草16份、南天仙子12份、素馨花10份、鸡脚参14份、惊风草12份、一匹草10份、叶下珠14份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2008年6月-2011年9月间共收集95例慢性反流性肾病的门诊患者，年龄21-60岁，病程1-5年。随机分为：治疗组75例，空白组20例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(％) |
| 治疗组 | 75 | 16(21.3％) | 38(50.7％) | 21(28％) | 0 | 72％ |
| 空白组 | 20 | 0 | 5(25％) | 15(75％) | 0 | 25％ |
可见，本发明制得的药物能够安全有效治慢性反流性肾病。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：毛连14克、手参12克、水茄10克、金鸡脚10克、刺芫荽8克、骆驼蓬8克、假茶辣12克、猪肚子14克、崖姜14克、凤眼草16克、南天仙子12克、素馨花10克、鸡脚参14克、惊风草12克、一匹草10克、叶下珠14克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗慢性反流性肾病。口服，每日分早晚两次服用。
具体实施例2
称取：毛连14克、手参12克、水茄10克、金鸡脚10克、刺芫荽8克、骆驼蓬8克、假茶辣12克、猪肚子14克、崖姜14克、凤眼草16克、南天仙子12克、素馨花10克、鸡脚参14克、惊风草12克、一匹草10克、叶下珠14克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗慢性反流性肾病。口服，每日分早晚两次服用。
具体实施例3
称取：毛连14克、手参12克、水茄10克、金鸡脚10克、刺芫荽8克、骆驼蓬8克、假茶辣12克、猪肚子14克、崖姜14克、凤眼草16克、南天仙子12克、素馨花10克、鸡脚参14克、惊风草12克、一匹草10克、叶下珠14克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗慢性反流性肾病。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗慢性反流性肾病的中药，其特征在于，由以下重量配比的药材制备而成：毛连14份、手参12份、水茄10份、金鸡脚10份、刺芫荽8份、骆驼蓬8份、假茶辣12份、猪肚子14份、崖姜14份、凤眼草16份、南天仙子12份、素馨花10份、鸡脚参14份、惊风草12份、一匹草10份、叶下珠14份。
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1343504A (zh) * | 2000-09-15 | 2002-04-10 | 孔文舟 | 治疗肾病的药物组合物及其制备方法 |
| CN1973864A (zh) * | 2006-08-31 | 2007-06-06 | 胡瑞 | 一种治疗血尿及肾盂肾炎的药物组合物及其制备方法 |
| CN102451458A (zh) * | 2010-10-27 | 2012-05-16 | 赵传利 | 一种治疗慢性肾盂肾炎的中药配方 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1343504A (zh) * | 2000-09-15 | 2002-04-10 | 孔文舟 | 治疗肾病的药物组合物及其制备方法 |
| CN1973864A (zh) * | 2006-08-31 | 2007-06-06 | 胡瑞 | 一种治疗血尿及肾盂肾炎的药物组合物及其制备方法 |
| CN102451458A (zh) * | 2010-10-27 | 2012-05-16 | 赵传利 | 一种治疗慢性肾盂肾炎的中药配方 |
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