CN103550659B - 一种治疗腹型偏头痛综合征的中药 - Google Patents
一种治疗腹型偏头痛综合征的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗腹型偏头痛综合征的中药，由以下重量配比的药材制备而成：山大颜10份、垂果南芥14份、草金杉14份、穿耳菝葜8份、臭矢菜12份、苍山黄堇10份、刺藜12份、川鄂山茱萸8份、长隔距兰14份、春砂花12份、陈壶卢瓢10份、叉枝鸦葱8份、慈竹花8份、逼血雷12份、博落回14份、崩疮药12份、大夜关门10份、厚叶子树11份。临床实验证明，本发明能够安全有效治疗腹型偏头痛综合征。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗腹型偏头痛综合征的中药。
背景技术
腹型偏头痛综合征临床表现为发作性腹痛，持续数分钟或数日。腹痛与偏头痛可同时出现，或腹痛时无偏头痛，或腹痛与偏头痛交替发生。发病时可伴有发热、寒战、恶心、呕吐及/或腹泻，多汗、皮肤苍白或暗红色，同时有疲乏感。有时易误诊为胃肠炎、胰腺炎、阑尾炎等，但经检查腹内无器质性病变。本病发作间歇期内一切正常。
对于腹型偏头痛综合征目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
山大颜【来源】为茜草科九节属植物九节Psychotria rubra （Lour.） Poir.，以根、叶入药。全年采集，鲜用或洗净切片晒干。【功能主治】清热解毒，消肿拔毒。根、叶：白喉，扁桃体炎，咽喉炎，痢疾，肠伤寒，胃痛，风湿骨痛；叶：外用治跌打肿痛，外伤出血，毒蛇咬伤，疮疡肿毒，下肢溃疡。
垂果南芥【来源】为十字花科植物垂果南芥的果实。秋季采收，晒干酒炒。【功能主治】清热，解毒，消肿。治疮痈肿毒。
草金杉【来源】为菊科植物自背苇谷草的全草。夏、秋季采，洗净，晒干或鲜用。【功能主治】清热解毒，利水通淋。治疳积
穿耳菝葜【来源】百合科穿耳菝葜Smilax perfoliata Lour.，以根状茎入药。【功能主治】健脾益胃，强筋壮骨。治风湿腰痛。
臭矢菜【来源】白花菜科臭矢菜Cleome vircosa L.，以全草入药。【功能主治】散瘀消肿，去腐生肌。跌打肿痛，劳伤腰痛：鲜全草捣烂，酒炒外敷。
苍山黄堇【来源】为罂粟科植物苍山黄堇的全草。春、夏季采收，洗净，晒干或鲜用。【功能主治】清热解毒。主肝炎；肺炎；痈肿疮疖；毒蛇咬伤。
刺藜【来源】为藜科植物刺藜的全草。夏、秋季收割全草，除去杂质，洗净晒干。【功能主治】活血；调经；祛风止痒。主月经过多；痛经；闭经；过敏性皮炎；等麻疹。
川鄂山茱萸【来源】为山茱萸科植物川鄂山茱萸的果实。秋季果熟果分批采摘，将鲜果置沸水中煮10-15min，及时捞出浸入冷水，趁热挤出种子，取果肉晒干或烘干即成。【功能主治】补肝益肾；收敛固脱。主肝肾亏虚；头晕目眩；耳聋耳鸣；腰膝酸软；遗精；尿频；体虚多汗。
长隔距兰【来源】兰科长隔距兰Sarcanthus elongatus Rolfe，以全草入药。【功能主治】舒筋活络，祛痰止咳。
春砂花【来源】为姜科植物阳春砂的花朵及花序梗。【功能主治】利肺快膈，调中和胃。宽胸理气，化痰，治喘咳。
陈壶卢瓢【来源】为葫芦科植物葫芦瓠瓜和小葫芦的老熟果实果壳。葫芦和瓠瓜：秋末冬初采取老熟果实，切开，除去瓤心种子，打碎，晒干。【功能主治】利水；消肿。主水肿；膨胀。
叉枝鸦葱【来源】菊科叉枝鸦葱Scorzonera divaricata Turcz.，以鲜植物汁液入药。【功能主治】消肿散结。主治瘊子。
慈竹花【来源】为禾本科植物慈竹的花，植物形态详慈竹叶条。【功用主治】治痨伤吐血：鲜慈竹花半斤，鲜黄桷树寄生半斤，炖黄牛肉或杀口肉服。
逼血雷【来源】马兜铃科马兜铃属植物管花马兜铃Aristolochia tubiflora Dunn，以根入药。冬季采挖，洗净切段，晒干或鲜用。【功能主治】清热解毒，止痛。用于胃痛；外用治毒蛇咬伤。
博落回【来源】罂粟科博落回属植物博落回Macleaya cordata （Willd.） R. Brown，以全草入药。秋季采收，晒干。【功能主治】祛风解毒，散瘀消肿。用于跌打损伤，风湿关节痛，痈疖肿毒，下肢溃疡。
崩疮药【来源】为野牡丹科植物柏拉木的根、叶。秋、冬季挖取根部，洗净，切片，晒干，秋季采叶，鲜用或晒干研粉备用。【功能主治】收敛止血；清热解毒。主产后流血不止；月经过多；肠炎；腹泻；风湿骨痛；肝硬化；疮疡肿毒；烫火伤；跌打肿痛；外伤出血；湿疹；疥癞。
大夜关门【来源】为豆科羊蹄甲属植物多脉羊蹄甲Bauhinia pernervosa L.Chen，以根和叶入药。秋季挖根；夏日采叶，洗净晒干。【功能主治】补肾固精，止咳，止血。根：遗精，遗尿，咳嗽，血崩。叶：脱肛，子宫脱垂。
厚叶子树【来源】黄杨科野扇花属植物云南野扇花Sarcococca hookeriana Baill.，以全株入药。全年可采，晒干。【功能主治】散瘀止血，行气止痛，拔毒生肌。用于胃痛，支气管炎，肝炎，蛔虫症；外用治跌打损伤，刀伤出血，无名肿毒。
发明内容
本发明旨在提供一种治疗腹型偏头痛综合征的中药，通过选择合适的药材及其配比，达到安全有效治愈腹型偏头痛综合征的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗腹型偏头痛综合征的中药，其特征在于，由以下重量配比的药材制备而成：山大颜10份、垂果南芥14份、草金杉14份、穿耳菝葜8份、臭矢菜12份、苍山黄堇10份、刺藜12份、川鄂山茱萸8份、长隔距兰14份、春砂花12份、陈壶卢瓢10份、叉枝鸦葱8份、慈竹花8份、逼血雷12份、博落回14份、崩疮药12份、大夜关门10份、厚叶子树11份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2011年7月-2012年12月间共收集80例腹型偏头痛综合征的门诊患者，年龄27-51岁，病程1-7年。随机分为：治疗组50例，空白组30例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，观察三个月未见反复。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 |
| 治疗组 | 50 | 7（14%） | 24（48%) | 19(38%) | 62% | 0 |
| 空白组 | 30 | 1（3.3%） | 4(13.3%) | 25（83.4%） | 16.6% | 0 |
可见，本发明制得的药物能够安全有效治疗腹型偏头痛综合征。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：山大颜10克、垂果南芥14克、草金杉14克、穿耳菝葜8克、臭矢菜12克、苍山黄堇10克、刺藜12克、川鄂山茱萸8克、长隔距兰14克、春砂花12克、陈壶卢瓢10克、叉枝鸦葱8克、慈竹花8克、逼血雷12克、博落回14克、崩疮药12克、大夜关门10克、厚叶子树11克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗腹型偏头痛综合征。口服，每日分早晚两次服用。
具体实施例2
称取：山大颜10克、垂果南芥14克、草金杉14克、穿耳菝葜8克、臭矢菜12克、苍山黄堇10克、刺藜12克、川鄂山茱萸8克、长隔距兰14克、春砂花12克、陈壶卢瓢10克、叉枝鸦葱8克、慈竹花8克、逼血雷12克、博落回14克、崩疮药12克、大夜关门10克、厚叶子树11克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗腹型偏头痛综合征。口服，每日分早晚两次服用。
具体实施例3
称取：山大颜10克、垂果南芥14克、草金杉14克、穿耳菝葜8克、臭矢菜12克、苍山黄堇10克、刺藜12克、川鄂山茱萸8克、长隔距兰14克、春砂花12克、陈壶卢瓢10克、叉枝鸦葱8克、慈竹花8克、逼血雷12克、博落回14克、崩疮药12克、大夜关门10克、厚叶子树11克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗腹型偏头痛综合征。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗腹型偏头痛综合征的中药，其特征在于，由以下重量配比的药材制备而成：山大颜10份、垂果南芥14份、草金杉14份、穿耳菝葜8份、臭矢菜12份、苍山黄堇10份、刺藜12份、川鄂山茱萸8份、长隔距兰14份、春砂花12份、陈壶卢瓢10份、叉枝鸦葱8份、慈竹花8份、逼血雷12份、博落回14份、崩疮药12份、大夜关门10份、厚叶子树11份。
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