CN103623187B - 一种治疗闭角型青光眼的中药 - Google Patents
一种治疗闭角型青光眼的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗闭角型青光眼的中药，由以下重量配比的药材制备而成：绒毛鸭脚木20份、对叶豆14份、稻槎菜10份、四棱筋骨草14份、赤胫散16份、东廧子12份、齿叶橐吾14份、地梭罗8份、刺瓜米草10份、凤尾猪鬃草15份、长梗排草12份、丁癸草根14份、飞机草10份、多穗蓼12份、二色内风消12份、川滇桤木14份、大叶云实14份、秃疮花10份。临床实验证明，本发明能够安全有效治疗闭角型青光眼。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗闭角型青光眼的中药。
背景技术
闭角型青光眼是一种常见的青光眼类型，是由于患者的前房角关闭，眼内的房水派出受阻所致。闭角型青光眼有原发性闭角型青光眼和继发性闭角型青光眼。原发性闭角型青光眼是指没有其他眼病存在，单由于患者的瞳孔阻滞，或患者虹膜根部肥厚、前移，导致前房角关闭、房水流出困难、眼压升高的一种情况。慢性闭角型青光眼其特点是有不同程度的眼部不适，发作性视朦与虹视。冬秋发作比夏季多见，多数在傍晚或午后出现症状，经过睡眠或充分休息后，眼压可恢复正常，症状消失。少数人无任何症状。
对于闭角型青光眼目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
绒毛鸭脚木【来源】五加科植物穗序鹅掌柴Agalma delavayi （Franch.） Hutch.，以根或茎入药。全年可采，切片晒干。【功能主治】祛风活络，补肝肾，强筋骨。用于骨折，扭挫伤，腰肌劳损，风湿关节痛，肾虚腰痛，跌打损伤恢复期。
对叶豆【来源】为豆科植物翅荚决明的叶夏、秋季选晴天采摘，除去茎枝，洗净，鲜用或晒干。【功能主治】祛风燥湿，止痒，缓泻。主湿疹，皮肤瘙痒，牛皮癣，神经性皮炎，疱疹，疮疖肿疡，便秘。
稻槎菜【来源】菊科稻槎菜Lapsana apogonoides Maxim.，以全草入药。【功能主治】清热凉血，消痈解毒。主治喉炎，痢疾下血，乳痈。
四棱筋骨草【来源】为马鞭草科四棱草属植物四棱筋骨草Schnabelia oligophylla Hand.-Mazz.的全草。四季可采，鲜用或晒干。【功能主治】祛风除湿，舒筋活络。用于风湿筋骨疼痛，腰痛，四肢麻木，跌打肿痛。
赤胫散【来源】为蓼科植物赤胫散和缺腰叶蓼的全草。夏、秋采收，扎把晒干或鲜用。【功能主治】清热解毒；活血舒筋。主痢疾；泄泻；赤白带下；经闭；痛经；乳痈；疮疖；无名肿毒；毒蛇咬伤；跌打损伤；劳伤腰痛。
东廧子【来源】为藜科植物沙蓬的种子。秋季果实成熟后打下种子，去掉杂质，晒干。【功能主治】健脾消食；发表解热；利水。主饮食积滞；噎膈反胃；感冒发烧；肾炎。
齿叶橐吾【来源】菊科齿叶橐吾Ligularia dentata （A. Gray） Hara，以根入药。【功能主治】舒筋活血，散瘀止痛。主治跌打损伤，疼痛。
【来源】为地钱科植物地钱的全体。全年可采。【功能主治】生肌，拔毒，清热。地棠花【来源】为蔷薇科植物绣线梅的花。7-8月花开时采摘，晒干。【功能主治】抗痨。主肺痨。
刺瓜米草【来源】为百合科植物刺瓜米草的根。全年可采。【功能主治】清热，利尿，驱风。治风湿性关节炎，小便赤。
凤尾猪鬃草【来源】为铁角蕨科植物云南铁角蕨的全草。秋季采收，洗净，晒干，切段。【功能主治】清热解毒；利尿；通乳。主感冒发热；小儿惊风；尿路感染；乳腺炎；乳汁不通。
长梗排草【来源】为报春花科植物长梗过路黄的全草。夏季采收，晒干。【功能主治】熄风定惊；收敛止血。主小儿惊风；肺痨咯血；刀伤出血。
丁癸草根【来源】豆科植物丁癸草的根。【功能主治】清热，解毒。治痈疽，疗疮，脚气浮肿，瘰疬。
飞机草【来源】为菊科植物飞机草的全草。夏、秋季采收，洗净，鲜用。【功能主治】散瘀消肿；解毒；止血。主跌打肿痛；疮疡肿毒；稻田性皮炎；外伤出血；旱蚂蝗咬后流血不止。
多穗蓼【来源】为蓼科植物多穗蓼的全草。6～10月采收全草，扎把晒干。【功能主治】清热解毒；祛风利湿。主痢疾；泄泻；小儿消化不良；风湿肿痛；跌打损伤。
二色内风消【来源】为五味子科植物二色五味子的根、藤茎。全年可采，除尽杂物，晒干。【功能主治】通经活络；健脾开胃。主劳伤脱力；四肢酸麻；胸闷；纳呆。
川滇桤木【来源】为桦木科植物川滇桤木的嫩茎叶或树皮。夏、秋季采摘嫩枝叶，或剥取树皮，鲜用或晒干。【功能主治】凉血解毒。主吐血；衄血；腹泻；痢疾；疮疡。
大叶云实【来源】为豆科植物大叶云实的枝、果、根。秋季采收。【功能主治】舒筋活络，补虚。
秃疮花【来源】罂粟科秃疮花属植物秃疮花Dicranostigma leptopodum （Maxim.） Fedde，以全草入药。春夏采集，晒干。【功能主治】清热解毒，消肿止痛，杀虫。用于扁桃体炎，牙痛，淋巴结结核；外用治头癣，体癣。
发明内容
本发明旨在提供一种治疗闭角型青光眼的中药，通过选择合适的药材及其配比，达到安全有效治愈闭角型青光眼的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗闭角型青光眼的中药，其特征在于，由以下重量配比的药材制备而成：绒毛鸭脚木20份、对叶豆14份、稻槎菜10份、四棱筋骨草14份、赤胫散16份、东廧子12份、齿叶橐吾14份、地梭罗8份、刺瓜米草10份、凤尾猪鬃草15份、长梗排草12份、丁癸草根14份、飞机草10份、多穗蓼12份、二色内风消12份、川滇桤木14份、大叶云实14份、秃疮花10份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2011年4月-2012年10月间共收集101例闭角型青光眼的门诊患者，年龄21-55岁，病程1-5年。随机分为：治疗组75例，空白组26例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程30天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程30天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，愈后观察三个月未见复发。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 |
| 治疗组 | 75 | 19（25.3%） | 38（50.7%) | 18（24%) | 76% | 0 |
| 空白组 | 26 | 0 | 3（11.5%） | 23（88.5%） | 11.5% | 0 |
可见，本发明制得的药物能够安全有效治疗闭角型青光眼。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：绒毛鸭脚木20克、对叶豆14克、稻槎菜10克、四棱筋骨草14克、赤胫散16克、东廧子12克、齿叶橐吾14克、地梭罗8克、刺瓜米草10克、凤尾猪鬃草15克、长梗排草12克、丁癸草根14克、飞机草10克、多穗蓼12克、二色内风消12克、川滇桤木14克、大叶云实14克、秃疮花10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗闭角型青光眼。口服，每日分早晚两次服用。
具体实施例2
称取：绒毛鸭脚木20克、对叶豆14克、稻槎菜10克、四棱筋骨草14克、赤胫散16克、东廧子12克、齿叶橐吾14克、地梭罗8克、刺瓜米草10克、凤尾猪鬃草15克、长梗排草12克、丁癸草根14克、飞机草10克、多穗蓼12克、二色内风消12克、川滇桤木14克、大叶云实14克、秃疮花10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗闭角型青光眼。口服，每日分早晚两次服用。
具体实施例3
称取：绒毛鸭脚木20克、对叶豆14克、稻槎菜10克、四棱筋骨草14克、赤胫散16克、东廧子12克、齿叶橐吾14克、地梭罗8克、刺瓜米草10克、凤尾猪鬃草15克、长梗排草12克、丁癸草根14克、飞机草10克、多穗蓼12克、二色内风消12克、川滇桤木14克、大叶云实14克、秃疮花10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗闭角型青光眼。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗闭角型青光眼的中药，其特征在于，由以下重量配比的药材制备而成：绒毛鸭脚木20份、对叶豆14份、稻槎菜10份、四棱筋骨草14份、赤胫散16份、东廧子12份、齿叶橐吾14份、地梭罗8份、刺瓜米草10份、凤尾猪鬃草15份、长梗排草12份、丁癸草根14份、飞机草10份、多穗蓼12份、二色内风消12份、川滇桤木14份、大叶云实14份、秃疮花10份。
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