CN103610990B - 一种治疗肾病综合征的中药 - Google Patents
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Abstract
本发明涉及一种治疗肾病综合征的中药，由以下重量配比的药材制备而成：大透骨消10份、柄果槲寄生14份、稗米20份、扁轴木16份、野海棠12份、手参16份、白头翁茎叶18份、刺菱14份、千只眼14份、长梗千里光15份、麦角18份、大独脚金12份、黄花虱麻头10份、苋菜20份、多苞糙苏15份。临床实验证明，本发明能够安全有效治疗肾病综合征。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗肾病综合征的中药。
背景技术
肾病综合征（NS）可由多种病因引起，以肾小球基膜通透性增加，表现为大量蛋白尿、低蛋白血症、高度水肿、高脂血症的一组临床症候群。分为原发性、继发性和遗传性三大类，最基本的特征是大量蛋白尿、低蛋白血症、（高度）水肿和高脂血症，即所谓的“三高一低”，及其他代谢紊乱为特征的一组临床症候群。大量蛋白尿是肾病综合征患者最主要的临床表现，也是肾病综合征的最基本的病理生理机制。
对于肾病综合征目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
大透骨消【来源】为杜鹃花科植物地檀香的根或叶。秋季采根，夏季采叶，晒干。【功能主治】祛风，除湿。治风湿瘫痪，冻疮。
柄果槲寄生【来源】为桑寄生科植物柄果槲寄生的带叶茎枝。全年均可采，扎成束，晾干。【功能主治】祛风湿；补肝肾；活血止痛；安胎；下乳。主主治风湿痹痛；腰腿痛；跌打损伤；高血压；胎动不安；乳汁不下。
稗米【来源】为禾本科植物稗的种子。夏、秋季果实成熟时采收，舂去壳，晒干。【功能主治】。主益气宜脾
扁轴木【来源】为豆科植物扁轴木的枝树皮或叶。四季均可采收，鲜用或晒干。【功能主治】补益。主身体衰弱；劳伤乏力；虚热；自汗；盗汗。
野海棠【来源】野牡丹科野海棠属植物秀丽野海棠，以根或全株入药。全年可采，洗净晒干。 【功能主治】祛风利湿，活血调经。用于风湿性关节炎，月经不调，白带，跌打损伤，毒蛇咬伤。
手参【来源】为兰科手参属植物手参的块根。秋季采挖，去茎叶及须根，洗净，放入开水锅内煮至无心白为度，捞出晒干。【功能主治】补肾益精，理气止痛。病后体弱，神经衰弱，咳嗽，阳痿，久泻，白带，跌打损伤，淤血肿痛。
白头翁茎叶【来源】为毛茛科植物白头翁的茎叶。【功能主治】治腰膝肢节风痛，浮肿及心脏病。
刺菱【来源】为菱科植物野菱的果实。【功能主治】《纲目拾遗》：生食补脾健胃，止渴生津，平肝气，通肾水，益血消食。老者煮食，健脾，止泄痢。
千只眼【来源】芸香科九里香属植物千只眼，以叶和根入药。夏秋采叶，秋季采根，洗净切段，均可鲜用或阴干备用。【功能主治】祛风解表，行气止痛，活血散瘀。用于感冒发热，支气管炎，哮喘，风湿麻木，筋骨疼痛，跌打瘀血肿痛，皮肤瘙痒，湿疹，毒蛇咬伤，疟疾，胃痛，水肿等。
长梗千里光【来源】为菊科植物长梗千里光的花序和全草。夏、秋间采收，晒干。【功能主治】清热解毒；明目。主痈肿疮疖；目赤肿痛。
麦角【来源】为麦角菌科麦角菌属的麦角菌在寄主植物上所形成的菌核。夏秋麦穗黄熟时采收。阴干或烘干备用。【功能主治】收缩子宫，止血。用于产后子宫出血（促子宫复位），偏头痛。
大独脚金【来源】玄参科独脚金属植物大独脚金以全草入药。夏秋采集，切碎，晒干。【功能主治】健脾消食，清热利湿。用于小儿疳积，食欲不振，泌尿道感染，黄疸型肝炎。
黄花虱麻头【来源】椴树科刺蒴麻属植物刺蒴麻，以全株入药。四季可采，晒干。【功能主治】解表清热，利尿散结。用于风热感冒，泌尿系结石。
苋菜【来源】苋科苋属植物苋。【功能主治】子：清肝明目。用于角膜云翳，目赤肿痛。根：凉血解毒，止痢。用于细菌性痢疾，肠炎，红崩白带，痔疮。
多苞糙苏【来源】唇形科多苞糙苏Phlomis bracteosa Royle，以全草、根入药。【功能主治】祛风除湿。半身不遂，口眼歪斜，风瘫壅盛，萎痹不仁，白癫风，眉发脱落。
发明内容
本发明旨在提供一种治疗肾病综合征的中药，通过选择合适的药材及其配比，达到安全有效治愈肾病综合征的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗肾病综合征的中药，其特征在于，由以下重量配比的药材制备而成：大透骨消10份、柄果槲寄生14份、稗米20份、扁轴木16份、野海棠12份、手参16份、白头翁茎叶18份、刺菱14份、千只眼14份、长梗千里光15份、麦角18份、大独脚金12份、黄花虱麻头10份、苋菜20份、多苞糙苏15份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2011年5月-2012年11月间共收集122例肾病综合征的门诊患者，年龄26-56岁，病程1-3年。随机分为：治疗组97例，空白组25例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程30天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程30天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，愈后观察三个月未见复发。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 |
| 治疗组 | 97 | 31（32%） | 59（60.8%) | 7（7.2%) | 92.8% | 0 |
| 空白组 | 25 | 1（4%） | 4（16%） | 20（80%） | 20% | 0 |
可见，本发明制得的药物能够安全有效治疗肾病综合征。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：大透骨消10克、柄果槲寄生14克、稗米20克、扁轴木16克、野海棠12克、手参16克、白头翁茎叶18克、刺菱14克、千只眼14克、长梗千里光15克、麦角18克、大独脚金12克、黄花虱麻头10克、苋菜20克、多苞糙苏15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗肾病综合征。口服，每日分早晚两次服用。
具体实施例2
称取：大透骨消10克、柄果槲寄生14克、稗米20克、扁轴木16克、野海棠12克、手参16克、白头翁茎叶18克、刺菱14克、千只眼14克、长梗千里光15克、麦角18克、大独脚金12克、黄花虱麻头10克、苋菜20克、多苞糙苏15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗肾病综合征。口服，每日分早晚两次服用。
具体实施例3
称取：大透骨消10克、柄果槲寄生14克、稗米20克、扁轴木16克、野海棠12克、手参16克、白头翁茎叶18克、刺菱14克、千只眼14克、长梗千里光15克、麦角18克、大独脚金12克、黄花虱麻头10克、苋菜20克、多苞糙苏15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗肾病综合征。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗肾病综合征的中药，其特征在于，由以下重量配比的药材制备而成：大透骨消10份、柄果槲寄生14份、稗米20份、扁轴木16份、野海棠12份、手参16份、白头翁茎叶18份、刺菱14份、千只眼14份、长梗千里光15份、麦角18份、大独脚金12份、黄花虱麻头10份、苋菜20份、多苞糙苏15份。
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| CN103127363A (zh) * | 2013-02-04 | 2013-06-05 | 云南云龙制药股份有限公司 | 一种治疗肾病的药物组合物 |
| CN103212031A (zh) * | 2013-04-24 | 2013-07-24 | 刘冰甜 | 用于治疗原发性肾病综合征的中药组合物及其制备方法 |
| CN103263559A (zh) * | 2013-04-07 | 2013-08-28 | 方岩松 | 一种治疗肾病综合症的中药 |
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| CN103127363A (zh) * | 2013-02-04 | 2013-06-05 | 云南云龙制药股份有限公司 | 一种治疗肾病的药物组合物 |
| CN103263559A (zh) * | 2013-04-07 | 2013-08-28 | 方岩松 | 一种治疗肾病综合症的中药 |
| CN103212031A (zh) * | 2013-04-24 | 2013-07-24 | 刘冰甜 | 用于治疗原发性肾病综合征的中药组合物及其制备方法 |
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