CN103705819B - 一种治疗肠白塞病的中药 - Google Patents
一种治疗肠白塞病的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗肠白塞病的中药，由以下重量配比的药材制备而成：滇姜三七12份、梅花草10份、罗望子14份、马桑10份、磨盘草14份、石榴根皮12份、灵香蒿14份、桃叶14份、针筒线15份、白花甜蜜蜜12份、女金丹16份、金丝带14份、黄芫花12份、白花丹14份、樱桃根14份、大叶山桂14份、下果藤12份、果上叶14份。临床实验证明，本发明能够安全有效治疗肠白塞病。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗肠白塞病的中药。
背景技术
肠白塞病是一种全身性、慢性、血管炎症性疾病，主要临床表现为复发性口腔溃疡、生殖器溃疡、眼炎及皮肤损害，也可累及血管、神经系统、消化道、关节、肺、肾、附睾等器官。该病具有一定的遗传因素，病情呈反复发作和缓解的交替过程。大部分患者预后良好，眼、中枢神经及大血管受累者预后不佳。白塞病合并胃肠道溃疡者又称为肠白塞病为白塞病的特殊类型。
对于肠白塞病目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
滇姜三七【来源】姜科曲蕊姜属植物曲蕊姜Camptandrayunnanensis(Gagnep.)K.Schum.，以球茎入药。秋季采挖，洗净去皮和毛，切片晒干研末。【功能主治】止血消肿。用于跌打损伤，骨折，吐血，衄血，功能性子宫出血；外用治外伤出血。
梅花草【来源】虎耳科梅花草属植物梅花草ParnassiapalustrisL.的全草。秋季采集全草，晒干。【功能主治】清热解毒，止咳化痰。用于细菌性痢疾，咽喉肿痛，百日咳，咳嗽痰多。
罗望子【来源】豆科罗望子属植物罗望子TamarindusindicaL.，以果实入药。春季采，除去种子，晒干。【功能主治】清热解暑，消食化积。用于中暑，食欲不振，小儿疳积，妊娠呕吐，便秘。
马桑【来源】马桑科马桑属植物马桑CoriariasinicaMaxim.，以根、叶入药。根冬季采挖，刮去外皮，晒干；叶夏季采，晒干。【功能主治】祛风除湿，镇痛，杀虫。根：用于淋巴结结核，跌打损伤，狂犬咬伤，风湿关节痛；叶：外用治烧烫伤，头癣，湿疹，疮疡肿毒。
磨盘草【来源】锦葵科苘麻属植物磨盘草Abutilonindicum(L.)G.Don，以全草或根入药。夏、秋采收，洗净晒干。【功能主治】疏风清热，益气通窍，祛痰利尿。用于感冒，久热不退，流行性腮腺炎，耳鸣，耳聋，肺结核，小便不利。
石榴根皮【来源】石榴科石榴属植物石榴PunicagranatumL.，以根、茎皮入药。全年可采，晒干。【功能主治】收敛止泻，杀虫。用于虚寒久泻，肠炎，痢疾，便血，脱肛，血崩，绦虫病，蛔虫病；外用治稻田皮炎。
灵香蒿【来源】菊科香青属植物稀毛香青AnaphalishancockiiMaxim.，以全草入药。夏季采收，阴干用。【功能主治】清热解毒，杀虫。用于子宫颈炎、阴道滴虫。
桃叶【来源】本品为蔷薇科植物桃Prunuspersica(L.)Batsch的叶。夏秋采收，鲜用或晒干。【功能主治】清热解毒，杀虫止痒。用于疟疾，痈疖，痔疮，湿疹，阴道滴虫。
针筒线【来源】柳叶菜科柳叶菜属植物长籽柳叶菜EpilobiumpyrricholophumFranch.etSavat.【功能主治】全草：活血，调经，止痢。用于月经不调，月经过多，便血，痢疾，并有安胎之效。种毛：止血。外用治刀伤出血。
白花甜蜜蜜【来源】唇形科青兰属植物异叶青兰DracocephalumheterophyllumBenth.，以全草入药。夏季采收，晒干。【功能主治】止咳，清肝火，散郁结。用于支气管炎，高血压病，甲状腺肿大，淋巴结结核，淋巴结炎；外用治口腔溃疡。
女金丹【来源】豆科胡枝子属植物绿叶胡枝子LespedezabuergeriMiq.，以根、叶入药。全年可采，切片晒干。【功能主治】解表祛湿，止痛，止血。用于感冒咳嗽，头痛，小儿痰哮，胃痛，黄疸，心绞痛，腰痛，子宫出血，乳癌初起，风湿性关节炎，疔疮，毒蛇咬伤。
金丝带【来源】地衣类松萝科树发属植物绿树发AlectoriavirensTayl.，以叶状体入药。四季可采，去杂质，晒干。【功能主治】祛风活络，补肾壮阳，调经止血。用于腰腿疼痛，半身不遂，肾虚腰痛，阳痿，头晕，月经不调，白带;外用治创伤出血。
黄芫花【来源】瑞香科荛花属植物河朔荛花WikstroemiachamaedaphneMeisn.的花蕾，叶也可入药。初秋采花蕾及叶，阴干或烘干。【功能主治】泻下逐水，通便。用于水肿胀满，痰饮积聚，咳逆喘满，急、慢性传染性肝炎，精神分裂症，癫痫。
白花丹【来源】为双子叶植物药白花丹科植物白花丹的全草及根。【功用主治】祛风，散瘀，解毒，杀虫。治风湿关节疼痛，血瘀经闭，跌打损伤，肿毒恶疮，疥癣。
樱桃根【来源】为蔷薇科植物樱桃的根，植物形态详樱桃条。【功用主治】治妇人气血不和，肝经火旺，手心潮烧，经闭。
大叶山桂【来源】为樟科樟属植物钝叶桂Cinnamomumobtusifolium(roxb.)Nees，以树皮入药。四季可采。【功能主治】温中散寒，理气止痛，止血，接骨。用于胃寒疼痛，虚寒泄泻，风湿骨痛，腰肌劳损，阳痿，闭经；外用治外伤出血，骨折，蛇咬伤。
下果藤【来源】为鼠李科嘴签属植物大苞嘴签GouanialeptostachyaDC.var.tonkinensisPitard.，以茎、叶入药。全年可采，【功能主治】凉血解毒，舒筋活络。用于肢体麻木;外用治烧烫伤，疮疡。
果上叶【来源】兰科石豆兰属植物极香石豆兰Bulbophyllumodoratissimum(Swartz)Lindl.，以全草入药。四季可采，洗净，鲜用或晒干。【功能主治】润肺化痰，舒筋活络，消炎。用于肺结核咯血，慢性气管炎，慢性咽炎，风湿筋骨疼痛；外用治骨折，跌打挫伤，刀伤。
发明内容
本发明旨在提供一种治疗肠白塞病的中药，通过选择合适的药材及其配比，达到安全有效治愈肠白塞病的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗肠白塞病的中药，其特征在于，由以下重量配比的药材制备而成：滇姜三七12份、梅花草10份、罗望子14份、马桑10份、磨盘草14份、石榴根皮12份、灵香蒿14份、桃叶14份、针筒线15份、白花甜蜜蜜12份、女金丹16份、金丝带14份、黄芫花12份、白花丹14份、樱桃根14份、大叶山桂14份、下果藤12份、果上叶14份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年11月-2012年9月间共收集88例肠白塞病的门诊患者，年龄20-57岁，病程1-7年。随机分为：治疗组60例，空白组28例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(％) |
| 治疗组 | 60 | 13(21.7％) | 34(56.7％) | 13(21.6％) | 0 | 78.4％ |
| 空白组 | 28 | 0 | 6(21.4％) | 22(78.6％) | 0 | 21.4％ |
可见，本发明制得的药物能够安全有效治肠白塞病。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：滇姜三七12克、梅花草10克、罗望子14克、马桑10克、磨盘草14克、石榴根皮12克、灵香蒿14克、桃叶14克、针筒线15克、白花甜蜜蜜12克、女金丹16克、金丝带14克、黄芫花12克、白花丹14克、樱桃根14克、大叶山桂14克、下果藤12克、果上叶14克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗肠白塞病。口服，每日分早晚两次服用。
具体实施例2
称取：滇姜三七12克、梅花草10克、罗望子14克、马桑10克、磨盘草14克、石榴根皮12克、灵香蒿14克、桃叶14克、针筒线15克、白花甜蜜蜜12克、女金丹16克、金丝带14克、黄芫花12克、白花丹14克、樱桃根14克、大叶山桂14克、下果藤12克、果上叶14克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤;合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗肠白塞病。口服，每日分早晚两次服用。
具体实施例3
称取：滇姜三七12克、梅花草10克、罗望子14克、马桑10克、磨盘草14克、石榴根皮12克、灵香蒿14克、桃叶14克、针筒线15克、白花甜蜜蜜12克、女金丹16克、金丝带14克、黄芫花12克、白花丹14克、樱桃根14克、大叶山桂14克、下果藤12克、果上叶14克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗肠白塞病。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗肠白塞病的中药，其特征在于，由以下重量配比的药材制备而成：滇姜三七12份、梅花草10份、罗望子14份、马桑10份、磨盘草14份、石榴根皮12份、灵香蒿14份、桃叶14份、针筒线15份、白花甜蜜蜜12份、女金丹16份、金丝带14份、黄芫花12份、白花丹14份、樱桃根14份、大叶山桂14份、下果藤12份、果上叶14份。
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