CN103536828B - 一种治疗支气管扩张的中药 - Google Patents
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Abstract
本发明涉及一种治疗支气管扩张的中药，由以下重量配比的药材制备而成：变叶美登木10份、宝盖草12份、饱饭花果12份、牛尾独活12份、闭鞘姜14份、冰草白穗12份、驴断肠8份、半蒴苣苔10份、白猪栗根14份、白脂麻8份、绵马贯众12份、布朗耳蕨10份、崩疮药11份、逼血雷10份、博落回12份、笔罗子14份、荜茇根14份、背花疮15份、荜澄茄12份、菝葜10份、标杆花12份、扁秆藨草10份。临床实验证明，本发明能够安全有效治疗支气管扩张。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗支气管扩张的中药。
背景技术
支气管扩张(bronchiectasis)是指近端中等大小支气管由于管壁的肌肉和弹性成分的破坏，导致其管腔形成异常的、不可逆性扩张、变形。本病多数为获得性，多见于儿童和青年。大多继发于急、慢性呼吸道感染和支气管阻塞后，患者多有童年麻疹、百日咳或支气管肺炎等病史。临床表现主要为慢性咳嗽、咳大量脓痰和(或)反复咯血。近年来随着急、慢性呼吸道感染的恰当治疗，其发病率有减少趋势。主要病因是支气管-肺组织感染和支气管阻塞。
对于支气管扩张目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
变叶美登木【来源】为卫矛科植物变叶美登木的地上部分，全年均可采，切段晒干。【功能主治】化瘀消肿解毒。主肿瘤。
宝盖草【来源】唇形科野芝麻属植物宝盖草LamiumamplexicauleL.的全草。春夏采收，洗净，鲜用或晒干。【功能主治】清热利湿，活血祛风，消肿解毒。用于黄疸型肝炎，淋巴结结核，高血压，面神经麻痹，半身不遂；外用治跌打伤痛，骨折，黄水疮。
饱饭花果【来源】为杜鹃花科植物西南越橘的果实。7-10月采收，晒干。【功能主治】强筋骨；益气力。主筋骨酸软；四肢无力。
牛尾独活【来源】伞形科牛尾独活属植物牛尾独活HeracleumvicinumBoiss.的根。秋季采收，去茎叶和细根，洗净晒干。【功能主治】祛风除湿，通痹止痛。用于风寒湿痹，腰膝疼痛，少阴伏风头痛。
闭鞘姜【来源】姜科闭鞘姜属植物闭鞘姜Costusspeciosus(Koenig)Smith，以根状茎入药。四季可采，以秋末为宜，洗净切片，蒸熟晒干。【功能主治】利水消肿，解毒止痒。用于百日咳，肾炎水肿，尿路感染，肝硬化腹水，小便不利；外用治荨麻疹，疮疖肿毒，中耳炎。
冰草白穗【来源】为禾本科植物赖草的带菌果穗。秋季采收。【功能主治】清热利湿。主淋证；赤白带下。
驴断肠【来源】毛茛科铁线莲属植物芹叶铁线莲ClematisaethusaefoliaTurcz.，以全草入药。夏季采收，晒干。【功能主治】祛风利湿，解毒止痛。用于风湿筋骨疼痛，下肢浮肿，痈疖肿毒。
半蒴苣苔【来源】为苦苣苔科植物半蒴苣苔的全草。夏、秋季采收，鲜用或晒干。【功能主治】清热；利湿；解毒。主湿热黄疸；咽喉肿痛；毒蛇咬伤；烧烫伤。
白猪栗根【来源】为壳斗科植物高山栲的根或茎皮。根全年可采，茎皮春、夏、秋季剥取，均晒干。【功能主治】收敛止泻。主肠炎；腹泻。
白脂麻【来源】为胡麻科植物脂麻的白色种子。【功能主治】润燥，滑肠。治脾约便难，小儿头疮。
绵马贯众【来源】为鳞毛蕨科植物粗茎鳞毛蕨DryopteriscrassirhizomaNakal的干燥根茎及叶柄残基。秋季采挖，削去叶柄，须根，除去泥沙，晒干。【功用主治】清热解毒，驱虫，止血。用于虫积腹痛，疮疡崩漏(炒炭)。
布朗耳蕨【来源】为鳞毛蕨科植物布朗耳蕨的根茎。夏、秋季采收。挖出后除去叶柄及须根，洗净，鲜用或晒干。【功能主治】清热解毒；止血；杀虫。主流感；乙脑；痄腮；鼻衄；崩漏；蛲虫病；头疮白秃。
崩疮药【来源】为野牡丹科植物柏拉木的根、叶。秋、冬季挖取根部，洗净，切片，晒干，秋季采叶，鲜用或晒干研粉备用。【功能主治】收敛止血；清热解毒。主产后流血不止；月经过多；肠炎；腹泻；风湿骨痛；肝硬化；疮疡肿毒；烫火伤；跌打肿痛；外伤出血；湿疹；疥癞。
逼血雷【来源】马兜铃科马兜铃属植物管花马兜铃AristolochiatubifloraDunn，以根入药。冬季采挖，洗净切段，晒干或鲜用。【功能主治】清热解毒，止痛。用于胃痛；外用治毒蛇咬伤。
博落回【来源】罂粟科博落回属植物博落回Macleayacordata(Willd.)R.Brown，以全草入药。秋季采收，晒干。【功能主治】祛风解毒，散瘀消肿。用于跌打损伤，风湿关节痛，痈疖肿毒，下肢溃疡。
笔罗子【来源】为清风藤科植物笔罗子的果实。秋季果实成熟时采收，晒干。【功能主治】解表，止咳。主感冒；咳嗽。
荜茇根【来源】为胡椒科植物荜茇的根。【功能主治】《本草拾遗》：主五劳七伤，阴汗，核肿。冷气呕逆，心腹胀满，食不消，寒疝核肿，妇人内冷无子。治腰肾冷，除血气。
背花疮【来源】为荨麻科植物盾叶冷水花的全草。夏季采收，鲜用或晒干。【功能主治】清热解毒；祛痰化瘀。主肺热咳喘；肺痨久咳；咯血；疮疡肿毒；跌打损伤；外伤出血；疳积。
荜澄茄【来源】为胡椒科植物荜澄茄的果实。在果实充分成长而未成熟仍呈青色时采收，连果枝摘下，晒干。【功能主治】温中散寒；行气止痛；暖肾。主胃寒呕逆；脘腹胀满冷痛；肠鸣泄泻；寒疝腹痛；寒湿小便淋沥浑浊。
菝葜【来源】为百合科植物菝葜的根茎。2月或8月采挖根茎，除去泥土及须根，晒干。【功能主治】祛风利湿；解毒消痈。主风湿痹痛；淋浊；带下；泄泻；痢疾；痈肿疮毒；顽癣；烧烫伤。
标杆花【来源】鸢尾科唐菖蒲属植物唐菖蒲GladiolusgandavensisVanHoutte，以球茎入药。秋季采集，洗净晒干或鲜用。【功能主治】解毒散瘀，消肿止痛。用于跌打损伤，咽喉肿痛。外用治腮腺炎，疮毒，淋巴结炎。
扁秆藨草【来源】为莎草科植物扁秆藨草的块茎。夏、秋季采收，除去茎叶及根茎，洗净，晒干。【功能主治】祛瘀通经；行气消积。主经闭；痛经；产后瘀阻腹痛；症瘕积聚；胸腹胁痛；消化不良。
发明内容
本发明旨在提供一种治疗支气管扩张的中药，通过选择合适的药材及其配比，达到安全有效治愈支气管扩张的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗支气管扩张的中药，其特征在于，由以下重量配比的药材制备而成：变叶美登木10份、宝盖草12份、饱饭花果12份、牛尾独活12份、闭鞘姜14份、冰草白穗12份、驴断肠8份、半蒴苣苔10份、白猪栗根14份、白脂麻8份、绵马贯众12份、布朗耳蕨10份、崩疮药11份、逼血雷10份、博落回12份、笔罗子14份、荜茇根14份、背花疮15份、荜澄茄12份、菝葜10份、标杆花12份、扁秆藨草10份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2011年6月-2013年1月间共收集135例支气管扩张的门诊患者，年龄13-26岁，病程1-2年。随机分为：治疗组100例，空白组35例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(％) |
| 治疗组 | 100 | 24(24％) | 52(52％) | 24(24％) | 0 | 76％ |
| 空白组 | 35 | 1(1％) | 5(14.3％) | 29(84.7％) | 0 | 15.3％ |
可见，本发明制得的药物能够安全有效治支气管扩张。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：变叶美登木10克、宝盖草12克、饱饭花果12克、牛尾独活12克、闭鞘姜14克、冰草白穗12克、驴断肠8克、半蒴苣苔10克、白猪栗根14克、白脂麻8克、绵马贯众12克、布朗耳蕨10克、崩疮药11克、逼血雷10克、博落回12克、笔罗子14克、荜茇根14克、背花疮15克、荜澄茄12克、菝葜10克、标杆花12克、扁秆藨草10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗支气管扩张。口服，每日分早晚两次服用。
具体实施例2
称取：变叶美登木10克、宝盖草12克、饱饭花果12克、牛尾独活12克、闭鞘姜14克、冰草白穗12克、驴断肠8克、半蒴苣苔10克、白猪栗根14克、白脂麻8克、绵马贯众12克、布朗耳蕨10克、崩疮药11克、逼血雷10克、博落回12克、笔罗子14克、荜茇根14克、背花疮15克、荜澄茄12克、菝葜10克、标杆花12克、扁秆藨草10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗支气管扩张。口服，每日分早晚两次服用。
具体实施例3
称取：变叶美登木10克、宝盖草12克、饱饭花果12克、牛尾独活12克、闭鞘姜14克、冰草白穗12克、驴断肠8克、半蒴苣苔10克、白猪栗根14克、白脂麻8克、绵马贯众12克、布朗耳蕨10克、崩疮药11克、逼血雷10克、博落回12克、笔罗子14克、荜茇根14克、背花疮15克、荜澄茄12克、菝葜10克、标杆花12克、扁秆藨草10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗支气管扩张。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗支气管扩张的中药，其特征在于，由以下重量配比的药材制备而成：变叶美登木10份、宝盖草12份、饱饭花果12份、牛尾独活12份、闭鞘姜14份、冰草白穗12份、驴断肠8份、半蒴苣苔10份、白猪栗根14份、白脂麻8份、绵马贯众12份、布朗耳蕨10份、崩疮药11份、逼血雷10份、博落回12份、笔罗子14份、荜茇根14份、背花疮15份、荜澄茄12份、菝葜10份、标杆花12份、扁秆藨草10份。
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| CN1342485A (zh) * | 2001-09-21 | 2002-04-03 | 徐海清 | 治疗外伤的外用药酒 |
| CN101129896A (zh) * | 2007-06-24 | 2008-02-27 | 晏正录 | 治疗肿瘤疾病的中草药药剂 |
| CN101564458A (zh) * | 2008-04-24 | 2009-10-28 | 北京以岭药业有限公司 | 一种中药组合物在制备治疗支气管炎药物中的应用 |
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| CN1342485A (zh) * | 2001-09-21 | 2002-04-03 | 徐海清 | 治疗外伤的外用药酒 |
| CN101129896A (zh) * | 2007-06-24 | 2008-02-27 | 晏正录 | 治疗肿瘤疾病的中草药药剂 |
| CN101564458A (zh) * | 2008-04-24 | 2009-10-28 | 北京以岭药业有限公司 | 一种中药组合物在制备治疗支气管炎药物中的应用 |
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| 《关于加强广防己等6种药材及其制剂监督管理的通知》;无;《药品监督管理局》;20040531;1 * |
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