CN103623186B - 一种治疗伪膜性肠炎的中药 - Google Patents
一种治疗伪膜性肠炎的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗伪膜性肠炎的中药，由以下重量配比的药材制备而成：过墙风12份、白猪栗14份、开口箭15份、心不干18份、甘紫菜12份、节节茶10份、垂花香薷15份、干饧糟18份、地钱12份、草龙14份、埃蕾12份、大五爪金龙18份、蟛蜞菊16份、东北堇菜14份、黑汉条12份、多鳞鳞毛蕨8份。临床实验证明，本发明能够安全有效治疗伪膜性肠炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗伪膜性肠炎的中药。
背景技术
伪膜性肠炎是一种主要发生于结肠和小肠的急性纤维素渗出性炎症，多系在应用抗生素后导致正常肠道菌群失调，难辨梭状芽胞杆菌大量繁殖，产生毒素而致病 。该病多发生于老年人、重症患者、免疫功能低下及外科大手术后的患者，其临床表现轻重不一，可仅为轻度腹泻，也可出现高热、严重腹泻、水电解质紊乱、中毒性巨结肠，甚至危及生命。该病病情重，治疗不及时病死率高。本病可发生于手术后，或因病情需要而接受抗生素治疗，机体的内环境发生变化，肠道菌群失调，使难辨梭状芽胞杆菌得以迅速繁殖并产生毒素而致病。
对于伪膜性肠炎目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
过墙风【来源】为马鞭草科植物尖齿臭茉莉带根的全株。全年均可采，洗净，切段晒干。【功能主治】祛风除湿；活血消肿。主风湿痹痛；偏头痛；白带；子宫脱垂；湿疹；疮疡。
白猪栗【来源】为壳斗科植物高山栲的果实。秋季采收，剥去总苞，晒干。【功能主治】宁心益肾。主心悸；耳鸣；腰痛。
开口箭【来源】为百合科开口箭属植物开口箭Tupistra chinensis Bak.，以根状茎入药。夏秋二季采挖，除去须根，洗净，晒干。 【功能主治】清热解毒，散淤止痛。用于白喉，风湿关节痛，腰腿疼，跌打损伤，毒蛇咬伤；外用治痈疖肿毒。
心不干【来源】为百合科开口箭属植物粗丝开口箭Tupistra pachynema Wanget Tang，以根状茎入药。秋季采挖，去须根，洗净切片晒干或鲜用。注：同属植物柄叶开口箭Tupistra wattii Hook. f.分布于云南省，在红河州也做心不干用。【功能主治】温中散寒，行气止痛。用于胃痛，跌打肿痛。
甘紫菜【来源】藻类红藻门甘紫菜Porphyra tenera Kjellm.，以叶状体入药。【功能主治】主治瘿瘤脚气。
节节茶【来源】金粟兰科金粟兰属植物鱼子兰Chloranthus officinalis Blume，以全株入药。全年可采，切碎晒干。【功能主治】通经活络，止血。用于感冒，肾结石，子宫脱垂，产后流血，癫痫，跌打劳伤，风湿麻木，关节炎，偏头痛；外用治骨折。
垂花香薷【来源】唇形科香薷属植物垂花香薷Elsholtzia penduliflora W. W. Smith，以全草入药。夏季采集，洗净晒干或鲜用。【功能主治】清热解毒，截疟。用于流行性脑脊髓膜炎，感冒，扁桃体炎，支气管炎，肺炎，疟疾；外用治乳腺炎，外伤感染。
干饧糟【来源】为制饴糖后所余之渣滓，经晒干而成。【功能主治】《纲目》：治反胃吐食，暖脾胃，化饮食，益气缓中。
地钱【来源】苔藓类地钱科地钱属植物地钱Marchantia polymorpha L.，以全草入药。四季可采，洗净，鲜用或晒干。【功能主治】解毒，祛瘀，生肌。外用治烧烫伤，骨折，毒蛇咬伤，疮痈肿毒，臁疮，癣。
草龙【来源】为柳叶菜科植物线叶丁香蓼的全草。夏、秋季采收全草，洗净，切段，晒干或鲜用。【功能主治】发表清热；解毒利尿；凉血止血。主感冒发热；咽喉肿痛；牙痛；口舌生疮；湿热泻痢；水肿；淋痛；疳积；咯血；咳血；吐血；便血；崩漏；痈疮疖肿。
为龙胆科植物百金花的带花全草。【功能主治】清热解毒。主肝炎；胆囊炎；头痛发热；牙痛；扁桃体炎。
大五爪金龙【来源】为葡萄科植物显孔崖爬藤的根或茎。秋、冬季采收，除去泥土，洗净，切片，鲜用或晒干。【功能主治】祛风湿；散瘀血；接骨。主风湿痹痛；跌打瘀肿；骨折。
蟛蜞菊【来源】菊科蟛蜞菊属植物蟛蜞菊Wedelia chinensis Merr.，以全草入药。夏秋采收，洗净，鲜用或晒干。【功能主治】清热解毒，化痰止咳，凉血平肝。用于预防麻疹，感冒发热，白喉，咽喉炎，扁桃体炎，支气管炎，肺炎，百日咳，咯血，高血压；外用治疔疮疖肿。
东北堇菜【来源】为堇菜科植物东北堇菜的全草。夏、秋季采收，洗净，鲜用或晒干。【功能主治】清热解毒；消肿排脓。主痈疽疔毒；目赤肿痛；咽喉肿痛；乳痈；黄疸；各种脓肿；淋巴结核；泄泻；痢疾。
黑汉条【来源】忍冬科荚蒾属植物黑汉条Viburnum utile Hemsl.，以根、全株入药。四季可采，以9～10月采根或全株较好，鲜用或晒干。【功能主治】清热利湿，祛风活络，凉血止血。用于痢疾，痔疮出血，风湿筋骨疼痛，跌打损伤，瘀血肿痛。
多鳞鳞毛蕨【来源】为鳞毛蕨科植物多鳞鳞毛蕨的根茎。全年均可采收，除去叶及杂质，鲜用或晒干。【功能主治】驱虫；解毒。主肠寄生虫病；食物中毒。
发明内容
本发明旨在提供一种治疗伪膜性肠炎的中药，通过选择合适的药材及其配比，达到安全有效治愈伪膜性肠炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗伪膜性肠炎的中药，其特征在于，由以下重量配比的药材制备而成：过墙风12份、白猪栗14份、开口箭15份、心不干18份、甘紫菜12份、节节茶10份、垂花香薷15份、干饧糟18份、地钱12份、草龙14份、埃蕾12份、大五爪金龙18份、蟛蜞菊16份、东北堇菜14份、黑汉条12份、多鳞鳞毛蕨8份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2011年7月-2012年11月间共收集88例伪膜性肠炎的门诊患者，年龄22-59岁，病程1-3年。随机分为：治疗组67例，空白组21例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程30天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程30天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，愈后观察三个月未见复发。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 |
| 治疗组 | 67 | 14（20.9%） | 42（62.7%) | 11（16.4%) | 83.6% | 0 |
| 空白组 | 21 | 0 | 2（9.5%） | 19（90.5%） | 9.5% | 0 |
可见，本发明制得的药物能够安全有效治疗伪膜性肠炎。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：过墙风12克、白猪栗14克、开口箭15克、心不干18克、甘紫菜12克、节节茶10克、垂花香薷15克、干饧糟18克、地钱12克、草龙14克、埃蕾12克、大五爪金龙18克、蟛蜞菊16克、东北堇菜14克、黑汉条12克、多鳞鳞毛蕨8克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗伪膜性肠炎。口服，每日分早晚两次服用。
具体实施例2
称取：过墙风12克、白猪栗14克、开口箭15克、心不干18克、甘紫菜12克、节节茶10克、垂花香薷15克、干饧糟18克、地钱12克、草龙14克、埃蕾12克、大五爪金龙18克、蟛蜞菊16克、东北堇菜14克、黑汉条12克、多鳞鳞毛蕨8克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗伪膜性肠炎。口服，每日分早晚两次服用。
具体实施例3
称取：过墙风12克、白猪栗14克、开口箭15克、心不干18克、甘紫菜12克、节节茶10克、垂花香薷15克、干饧糟18克、地钱12克、草龙14克、埃蕾12克、大五爪金龙18克、蟛蜞菊16克、东北堇菜14克、黑汉条12克、多鳞鳞毛蕨8克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗伪膜性肠炎。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗伪膜性肠炎的中药，其特征在于，由以下重量配比的药材制备而成：过墙风12份、白猪栗14份、开口箭15份、心不干18份、甘紫菜12份、节节茶10份、垂花香薷15份、干饧糟18份、地钱12份、草龙14份、埃蕾12份、大五爪金龙18份、蟛蜞菊16份、东北堇菜14份、黑汉条12份、多鳞鳞毛蕨8份。
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