CN103520390B - 一种治疗剥脱性皮炎型药疹的中药 - Google Patents
一种治疗剥脱性皮炎型药疹的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗剥脱性皮炎型药疹的中药，由以下重量配比的药材制备而成：刀灰树10份、缠竹黄12份、楮头红12份、潮风12草份、樗白皮14份、大夜关门根10份、牛尾独活15份、糙叶五加10份、菜头肾12份、龙眼根14份、赪桐叶14份、绵马贯众10份、红毛七10份、小叶黑面叶12份、天蓬子根12份、三爪金龙14份、翅卫矛10份、大叶藜12份、千屈草12份、午时花10份。临床实验证明，本发明能够安全有效治疗剥脱性皮炎型药疹。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗剥脱性皮炎型药疹的中药。
背景技术
剥脱性皮炎型药疹是指由于药物引起的严重性皮炎，表现为全身皮肤红肿、剥脱，伴严重的全身症状。为严重类型药疹皮疹。初起多为麻疹样或猩红热样，继而迅速融合成片，全身皮肤呈弥漫性潮红肿胀，鲜红色到棕红色，以后大量脱屑，脱屑有干剥与湿剥两种，前者手足部脱屑如手套或袜状(套式剥脱)，躯干部脱屑呈落叶状，可持续1个月左右，头发及指(趾)甲均可脱落；后者可出现水疱及广泛性糜烂，尤其是皱褶部位。极大地影响患者形象，不仅会造成肉体上的伤痛，更会影响患者心理健康。
对于剥脱性皮炎型药疹目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
刀灰树【来源】为山矾科植物光叶山矾的根或叶。全年均可采。根，洗净，切片，晒干；叶，鲜用。【功能主治】止血生肌；和肝健脾。主外伤出血；吐血；咯血；疮疖；疳积；眼结膜炎。
缠竹黄【来源】龙胆科缠竹黄Tripterospermum cordifolium （Marq.） H. Smith，以全草入药。【功能主治】清肝肺火。主治咳嗽，急惊风，肝热目赤，口苦，黄疸，筋骨热痛等症。
楮头红【来源】为野牡丹科植物楮头红的全草。夏、秋季采收，鲜用或切碎晒干。【功能主治】清热平肝；利湿解毒。主肺热咳嗽；头目眩晕；耳鸣；耳聋；日赤羞明；肝炎；风湿痹痛；跌打伤肿；蛇头疔；无名肿毒。
潮风草【来源】萝藦科潮风草Cynanchum ascyrifolium （Franch. et Sav.） Matsum.，以根入药。【功能主治】清热凉血，利尿通淋，解毒疗疮。
樗白皮【来源】为苦木科植物臭椿的根皮或树干皮。春、夏季剥取根皮或干皮，刮去或不刮去粗皮，切块片或丝，晒干。【功能主治】清热燥湿；涩肠；止血；止带；杀虫。主泄泻；痢疾；便血；崩漏；痔疮出血；带下；蛔虫症；疮癣。
大夜关门根【来源】为豆科植物多脉叶羊蹄甲的根。夏、秋采收。【功能主治】止血，镇咳，补肾气。
牛尾独活【来源】伞形科牛尾独活属植物牛尾独活Heracleum vicinum Boiss.的根。秋季采收，去茎叶和细根，洗净晒干。【功能主治】祛风除湿，通痹止痛。用于风寒湿痹，腰膝疼痛，少阴伏风头痛。
糙叶五加【来源】为五加科植物糙叶五加的根皮。秋季挖根，洗净，除去须根，趁鲜用木槌敲击，使木心和皮部分离，抽去木心，切段，晒干。【功能主治】祛风利湿；活血舒筋；理气止痛。主风湿痹痛；拘挛麻木；筋骨痞软；水肿；跌打损伤；疝气腹痛。
菜头肾【来源】为爵床科植物菜头肾的根或全草。根，立秋后采挖，去净细须，晒干或鲜用；全草，夏、秋季采收，扎把，晒干。【功能主治】补肾养阴；清热解毒。主肾虎腰痛；虎火牙痛；肝炎；疔疮疖肿。
龙眼根【来源】无患子科龙眼属植物龙眼Dimocarpus longan Lour.，以根入药。全年可采。 【功能主治】利湿，通络。用于乳糜尿，白带，风湿关节痛。
赪桐叶【来源】为双子叶植物药马鞭草科植物赪桐的叶。全年均可采，晒干，研末或鲜用。【功能主治】祛风；散瘀；解毒消肿。主偏头痛；跌打瘀肿；痈肿疮毒。
绵马贯众【来源】为鳞毛蕨科植物粗茎鳞毛蕨Dryopteris crassirhizoma Nakal的干燥根茎及叶柄残基。秋季采挖，削去叶柄，须根，除去泥沙，晒干。【功用主治】清热解毒，驱虫，止血。用于虫积腹痛，疮疡崩漏（炒炭）。
红毛七【来源】为小檗科牡丹草属植物类叶牡丹Leontice robustum （Maxim.） Diels ，以根状茎入药。秋季采挖，洗净，切片晒干备用。【功能主治】理气止痛，祛风活血。用于月经不调，胃腹疼痛，跌打损伤，风湿疼痛。
小叶黑面叶【来源】大戟科山漆茎属植物小叶黑面叶Breynia patens Benth.，以根及叶入药。根全年可采，洗净晒干，或鲜用；叶夏季采摘，晒干。【功能主治】清热解毒，止血止痛。用于感冒发热，扁桃体炎，咽喉炎，急性胃肠炎，痢疾，月经过多，崩漏，白带，痛经；外用治外伤出血，疮疖，湿疹，皮肤瘙痒，烧伤。
天蓬子根【来源】为茄科东莨菪属植物天蓬子Scopolia sinensis Hemsl.的根。秋、冬采集，洗净，切片，晒干。【功能主治】祛风散寒，舒筋活络，止痛。用于跌打损伤，关节疼痛，瘫痪，破伤风。
三爪金龙【来源】为葡萄科爬山属植物三叶爬山虎 Parthenocissus himalayana （royle） Planch.，以根于茎入药。秋季采集，切段，晒干。【功能主治】祛风除湿，活络，散瘀。用于风湿骨痛；外用治骨折，跌打损伤。
翅卫矛【来源】为卫矛科植物栓翅卫矛的枝皮。7-8月采枝，刮取外皮，洗净，切段，晒干。【功能主治】活血调经；散瘀止痛。主有经不调；产后瘀阴腹痛；跌打损伤；风湿痹痛。
大叶藜【来源】为藜科藜属植物杂配藜Chenopodium hybridum L.，以地上部分入药。【功能主治】调经，止血。用于月经不调，功能性子宫出血，吐血，衄血，咯血，尿血。
千屈草【来源】为千屈草科千屈草属植物千屈菜Lythrum salicaria L.，以全草入药。夏秋采集，除去泥沙，晒干或鲜用。【功能主治】清热解毒，凉血止血。用于肠炎，痢疾，便血；外用治外伤出血。
午时花【来源】马齿苋科马齿苋属植物大花马齿苋Portulaca grandiflora Hook.，以地上全草入药。四季可采，一般鲜用，或晒干。【功能主治】散瘀止痛，解毒消肿。用于跌打损伤；外用治疮疖肿毒。
发明内容
本发明旨在提供一种治疗剥脱性皮炎型药疹的中药，通过选择合适的药材及其配比，达到安全有效治愈剥脱性皮炎型药疹的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗剥脱性皮炎型药疹的中药，其特征在于，由以下重量配比的药材制备而成：刀灰树10份、缠竹黄12份、楮头红12份、潮风12草份、樗白皮14份、大夜关门根10份、牛尾独活15份、糙叶五加10份、菜头肾12份、龙眼根14份、赪桐叶14份、绵马贯众10份、红毛七10份、小叶黑面叶12份、天蓬子根12份、三爪金龙14份、翅卫矛10份、大叶藜12份、千屈草12份、午时花10份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2010年5月-2011年12月间共收集129例剥脱性皮炎型药疹的门诊患者，年龄19-41岁，病程1-2年。随机分为：治疗组97例，空白组32例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，观察三个月未见反复。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 |
| 治疗组 | 97 | 27（27.8%） | 51（52.5%) | 19(19.6%) | 80.4% | 0 |
| 空白组 | 32 | 0 | 4(12.5%) | 28（87.5%） | 12.5% | 0 |
可见，本发明制得的药物能够安全有效治疗剥脱性皮炎型药疹。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：刀灰树10克、缠竹黄12克、楮头红12克、潮风12草克、樗白皮14克、大夜关门根10克、牛尾独活15克、糙叶五加10克、菜头肾12克、龙眼根14克、赪桐叶14克、绵马贯众10克、红毛七10克、小叶黑面叶12克、天蓬子根12克、三爪金龙14克、翅卫矛10克、大叶藜12克、千屈草12克、午时花10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗剥脱性皮炎型药疹。口服，每日分早晚两次服用。
具体实施例2
称取：刀灰树10克、缠竹黄12克、楮头红12克、潮风12草克、樗白皮14克、大夜关门根10克、牛尾独活15克、糙叶五加10克、菜头肾12克、龙眼根14克、赪桐叶14克、绵马贯众10克、红毛七10克、小叶黑面叶12克、天蓬子根12克、三爪金龙14克、翅卫矛10克、大叶藜12克、千屈草12克、午时花10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗剥脱性皮炎型药疹。口服，每日分早晚两次服用。
具体实施例3
称取：刀灰树10克、缠竹黄12克、楮头红12克、潮风12草克、樗白皮14克、大夜关门根10克、牛尾独活15克、糙叶五加10克、菜头肾12克、龙眼根14克、赪桐叶14克、绵马贯众10克、红毛七10克、小叶黑面叶12克、天蓬子根12克、三爪金龙14克、翅卫矛10克、大叶藜12克、千屈草12克、午时花10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗剥脱性皮炎型药疹。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗剥脱性皮炎型药疹的中药，其特征在于，由以下重量配比的药材制备而成：刀灰树10份、缠竹黄12份、楮头红12份、潮风草12份、樗白皮14份、大夜关门根10份、牛尾独活15份、糙叶五加10份、菜头肾12份、龙眼根14份、赪桐叶14份、绵马贯众10份、红毛七10份、小叶黑面叶12份、天蓬子根12份、三爪金龙14份、翅卫矛10份、大叶藜12份、千屈草12份、午时花10份。
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