CN102657837B - 一种治疗剥脱性皮炎的中药 - Google Patents
一种治疗剥脱性皮炎的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗剥脱性皮炎的中药，由以下重量配比的药材制成：生芪20-30份，人参20-30份，桂枝20-30份，熟附子20-30份，细辛10-20份，羌活10-20份，防风10-20份，川芎10-20份，煨生姜10-20份，赤芍10-20份，炙甘草10-20份，丹参10-20份，三七10-20份。实验证明，本发明的药能够安全有效治疗剥脱性皮炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗剥脱性皮炎的中药。
背景技术
剥脱性皮炎又称葡萄球菌性烫伤样皮肤综合征（staphylococcal scalded skin syndrome,SSSS）或Ritter氏病。该疾病由凝固酶阳性第Ⅱ噬菌体组金黄色葡萄球菌71型感染所致。本菌毒素能造成表皮松解。目前治疗采用的药物有较大的毒副作用，成本高，易反复，治愈率低，在治疗效果方面不能令人满意。因此研究开发一种安全有效治疗剥脱性皮炎的中药非常有实用价值。
本发明中药所涉及药材的研究现状如下：
生芪:【来源】本品为豆科植物蒙古黄芪 Astragalus membranaceus （Fisch.） Bge. var. mongholicus （Bge.）Hsiao 或膜荚黄芪 Astragalus membranaceus （Fisch.） Bge.的干燥根。【功能主治】补齐固表，托疮生肌。主治体虚自汗，久泻，脱肛，子宫脱垂，慢性肾炎，体虚浮肿，慢性溃疡，疮口久不愈合。
人参:【来源】本品为五加科植物人参Panax ginseng C. A. Mey.的干燥根。【功能主治】大补元气，复脉固脱，补脾益肺，生津，安神。用于体虚欲脱，肢冷脉微，脾虚食少，肺虚喘咳，津伤口渴，内热消渴，久病虚羸，惊悸失眠，阳痿宫冷；心力衰竭，心原性休克。
桂枝:【来源】本品为樟科植物肉桂 Cinnamomum cassia Presl的干燥嫩枝。【功能主治】发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。
熟附子:【来源】本品为毛茛科植物乌头Aconitum carmichaeli Debx.的子根的加工品。【功能主治】回阳救逆，补火助阳，逐风寒湿邪。用于亡阳虚脱，肢冷脉微，阳萎，宫冷，心腹冷痛，虚寒吐泻，阴寒水肿，阳虚外感，寒湿痹痛。
细辛:【来源】本品为马兜铃科植物北细辛Asarum heterotropoides Fr. Schmidt var.mandshuricum（Maxim.）Kitag. 、汉城细辛Asarum sieboldii Miq. var. seoulense Nakai或华细辛Asarum sieboldii Miq.的干燥全草。【功能主治】祛风散寒，通窍止痛，温肺化饮。用于风寒感冒，头痛，牙痛，鼻塞鼻渊，风湿痹痛，痰饮喘咳。
羌活:【来源】本品为伞形科植物羌活（背翅芹）Notopterygium incisum Ting ex H. T. Chang 或宽叶羌活Notopterygium forbesii Boiss. 的干燥根茎及根。【功能主治】散寒，祛风，除湿，止痛。用于风寒感冒头痛，风湿痹痛，肩背酸痛。
防风:【来源】本品为伞形科植物防风Saposhnikovia divaricata （Turcz.） Schischk. 的干燥根。【功能主治】解表祛风，胜湿，止痉。用于感冒头痛，风湿痹痛，风疹瘙痒，破伤风。
川芎:【来源】本品为伞形科植物川芎Ligusticum chuanxiong Hort.（或Ligusticum wallichii Franch.）的干燥根茎。【功能主治】活血行气，祛风止痛。用于月经不调，经闭痛经，症瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。
煨生姜: 【来源】为姜科植物姜的鲜根茎。将原只鲜生姜洗净，用草纸包裹，放在清水中浸湿，直接放在火中煨，待草纸焦黑，姜熟为度；或直接放火中烤熟。性味辛温，具有和中止呕的功用。
赤芍: 【来源】本品为毛茛科植物芍药Paeonia lactiflora Pall.或川赤芍Paeonia veitchii Lynch 的干燥根。【功能主治】清热凉血，散瘀止痛。用于温毒发斑，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，症瘕腹痛，跌扑损伤，痈肿疮疡。
炙甘草:【来源】本品为甘草的炮制加工品。【功能主治】补脾和胃，益气复脉。用于脾胃虚弱，倦怠乏力，心动悸，脉结代。
丹参:【来源】本品为唇形科植物丹参Salvia miltiorrhiza Bunge. 的干燥根及根茎。【功能主治】祛瘀止痛，活血通经，清心除烦。用于月经不调，经闭痛经，症瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。
三七：【来源】本品为五加科植物三七Panax notoginseng （Burk.）F. H. Chen的干燥根。【功能主治】散瘀止血，消肿定痛。用于咯血，吐血，衄血，便血，崩漏，外伤出血，胸腹剌痛，跌扑肿痛。
发明内容
本发明旨在提供一种治疗剥脱性皮炎的中药，通过选择合适的药材及其配比，达到安全有效治愈剥脱性皮炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗剥脱性皮炎的中药组合物，其特征在于，由以下重量配比的药材制成：生芪20-30份，人参20-30份，桂枝20-30份，熟附子20-30份，细辛10-20份，羌活10-20份，防风10-20份，川芎10-20份，煨生姜10-20份，赤芍10-20份，炙甘草10-20份，丹参10-20份，三七10-20份。
其中优选：生芪25份，人参25份，桂枝25份，熟附子25份，细辛15份，羌活15份，防风15份，川芎15份，煨生姜15份，赤芍15份，炙甘草-15份，丹参15份，三七15份。
下面结合中医理论说明本发明的有益效果：
发明人在实践过程中发现，剥脱性皮炎证属脾肾阳虚，致使阴寒内生。表现为全身皮肤脱屑，干燥，呈糠麸状，瘙痒，肤色暗红，头发稀疏，无汗，周身皮肤拘紧不适，畏寒肢冷，舌质淡紫，脉虚略数。本发明运用剥脱性皮炎：生芪，人参，桂枝，熟附子，细辛，羌活，防风，川芎，煨生姜，赤芍，炙甘草,丹参，三七综合作用从而有效地治疗剥脱性皮炎。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2008年6月-2012年2月间共收集75例剥脱性皮炎的门诊患者，其中男37例，女38例，年龄2月-30岁，病程1-5年。随机分为：治疗组50例，对照组25例。两组性别、年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1对照组采用苯海拉明每次50mg，每日3次或20mg肌内注射，每日3次。疗程2周。
2.2治疗组采用口服本发明优选配方按照具体实施例1制得的药物，早中晚各一次。疗程2周。
2.3观察项目：治疗前后红斑，松弛，大疱，大片糜烂，烫伤样，水疱手足皮肤呈套式或袜样剥脱程度等。观察三个月有无反复。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) |
| 治疗组 | 50 | 38(76%) | 10（20%) | 2(4%) | 96% |
| 对照组 | 25 | 16(64%) | 2(8%) | 7(28%) | 72% |
可见，本发明优选实施方式制得的药物能够安全有效治疗剥脱性皮炎。
根据上述临床实验数据，结合本发明治疗剥脱性皮炎的中医学机理分析和本领域公知常识，本领域技术人员容易推知，运用本发明中的药材，在最佳重量份附近取值，至少在“生芪20-30份，人参20-30份，桂枝20-30份，熟附子20-30份，细辛10-20份，羌活10-20份，防风10-20份，川芎10-20份，煨生姜10-20份，赤芍10-20份，炙甘草10-20份，丹参10-20份，三七10-20份”的范围内，可以取得与本发明优选实施方式制得的药物类似的技术效果。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取生地黄生芪20克，人参20克，桂枝20克，熟附子20克，细辛10克，羌活10克，防风10克，川芎10克，煨生姜10克，赤芍10克，炙甘草10克，丹参10克，三七10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗剥脱性皮炎。口服，每日分早晚两次服用，儿童用量酌减。
具体实施例2
称取生地黄生芪25克，人参25克，桂枝25克，熟附子25克，细辛15克，羌活15克，防风15克，川芎15克，煨生姜15克，赤芍15克，炙甘草15克，丹参15克，三七15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗剥脱性皮炎。口服，每日分早晚两次服用，儿童用量酌减。
具体实施例3
称取生地黄生芪30克，人参30克，桂枝30克，熟附子30克，细辛20克，羌活20克，防风20克，川芎20克，煨生姜20克，赤芍20克，炙甘草20克，丹参20克，三七20克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人一天用量的颗粒剂。
用于治疗剥脱性皮炎。口服，每日分早晚两次服用，儿童用量酌减。
Claims (1)
1.一种治疗剥脱性皮炎的中药组合物，其特征在于，由以下重量配比的药材制成：生芪25份，人参25份，桂枝25份，熟附子25份，细辛15份，羌活15份，防风15份，川芎15份，煨生姜15份，赤芍15份，炙甘草15份，丹参15份，三七15份。
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