CN103690848B - 一种治疗毒性弥漫性甲状腺肿的中药 - Google Patents
一种治疗毒性弥漫性甲状腺肿的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗毒性弥漫性甲状腺肿的中药，由以下重量配比的药材制备而成：乌鱼刺10份、红陈艾15份、朴松实10份、屈头鸡9份、石椒草10份、厚叶子树15份、打米花15份、滴血根9份、猫儿眼睛12份、梦花根15份、西藏鸡爪草12份、针筒线6份。临床实验证明，本发明能够安全有效治疗毒性弥漫性甲状腺肿。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗毒性弥漫性甲状腺肿的中药。
背景技术
毒性弥漫性甲状腺肿，又称Graves病，是甲状腺功能亢进症最常见的一种，是一种自身免疫性甲状腺疾病，其确切机制尚不明确。典型的临床表现为高代谢症群(怕热、多汗、皮肤潮湿)，甲状腺弥漫性肿大，滤泡细胞增生，并伴有淋巴细胞浸润，部分患者可伴有球后结缔组织增生和眼外肌水肿，引起眼突。现代医学治疗本病主要以药物治疗为主，如他巴唑或丙硫氧嘧啶，但其治疗疗程长，停药后易复发，并伴有肝功能损害和粒细胞减少等不良反应。鉴于中药毒副作用小、安全性好的特点，发挥中医药的优势，开展临床研究，从中药中寻找并开发出疗效肯定的药物，具有重要的临床意义。
本发明中药所涉及药材的研究现状如下：
乌鱼刺【来源】百合科菝葜属植物小叶菝葜SmilaxmicrophyllaC.H.Wright.，以块茎入药。四季可采，洗净切片晒干。【功能主治】清热解毒，祛湿消肿。用于红崩，白带，颈淋巴结结核，疮疖，跌打损伤。
红陈艾【来源】菊科艾属植物蒌蒿ArtemisiaselengensisTurcz.，以全草入药。秋季采，多鲜用。【功能主治】破血行瘀，下气通络。用于产后瘀血停积小腹胀痛，跌打损伤，淤血肿痛，因伤而大小便下血。
朴松实【来源】松科冷杉属植物四川冷杉AbiesfargesiiFranch.的球果。夏季采摘，晒干。【功能主治】平肝息风，调经，止血，止带。用于高血压病，头痛头晕，心神不安；月经不调，崩漏，白带。
屈头鸡【来源】白花菜科山柑属植物屈头鸡CapparisversicolorGriff.【C.KoiMerr.etChum】，以根及果实入药。秋季采果，晒干；根全年可采，切片晒干。【功能主治】果：止咳平喘。用于咳嗽，胸痛，哮喘。根：散瘀，消肿，止痛。外用治跌打损伤，骨折。
石椒草【来源】为芸香科松风草属植物石椒草BoenninghauseniasessilicarpaLevl.的全草。秋季割取全草，洗净切段晒干。【功能主治】清热解毒，活血止痛。用于感冒，扁桃体炎，腮腺炎，支气管炎，胃痛腹胀，血栓闭塞性脉管炎，腰痛，跌打损伤。
厚叶子树【来源】黄杨科野扇花属植物云南野扇花SarcococcahookerianaBaill.，以全株入药。全年可采，晒干。【功能主治】散瘀止血，行气止痛，拔毒生肌。用于胃痛，支气管炎，肝炎，蛔虫症；外用治跌打损伤，刀伤出血，无名肿毒。
打米花【来源】为双子叶植物药旋花科植物翼萼藤PoranaracemosaRoxb.的根或全草。夏、秋季采收，除去杂质，切碎，鲜用或晒干。【功能主治】解表；行气；活血；解毒。主感冒风寒；食滞腹胀；无名肿毒。
滴血根【来源】为菊科植物麻叶蟛蜞菊WedeliaurticifoliaDC.的根。秋后采挖，鲜用或切片晒干。【功能主治】补肾；养血；通络。主肾虚腰痛；气血虚弱；跌打损伤。
猫儿眼睛【来源】为蓼科植物尼泊尔蓼PolygonumnepalenseMeissn.[P.AlatumBuch.－Ham.ExD.Don]的全草。夏、秋间采收，晾干。【功能主治】清热解毒；除湿通络。主咽喉肿痛；目赤；牙龈肿痛；赤白痢疾；风湿痹痛。
梦花根【来源】瑞香科植物结香EndgeworthiachrysanthaLindl.的根皮及茎皮。全年可采，挖根，洗净，切片晒干。【功能主治】祛风通络；滋养肝肾。主风湿痹痛；跌打损伤；梦遗；早泄；血崩；白带。
西藏鸡爪草【来源】为毛茛科植物毛茛状金莲花TrolliusranunculoidesHemsl.的全草。夏季采收，晒干。【功能主治】祛风湿；散寒。主风湿麻木；关节疼痛拘挛；鸡爪风；淋巴结核。
针筒线【来源】为柳叶菜科柳叶菜属植物长籽柳叶菜EpilobiumpyrricholophumFranch.etSavat.[E.japonicumHausskn.]，以根、全草和种毛入药。秋后采，洗净晒干。【功能主治】全草：活血，调经，止痢。用于月经不调，月经过多，便血，痢疾，并有安胎之效。
发明内容
本发明旨在提供一种治疗毒性弥漫性甲状腺肿的中药，通过选择合适的药材及其配比，达到安全有效治愈毒性弥漫性甲状腺肿的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗毒性弥漫性甲状腺肿的中药，其特征在于，由以下重量配比的药材制备而成：乌鱼刺10份、红陈艾15份、朴松实10份、屈头鸡9份、石椒草10份、厚叶子树15份、打米花15份、滴血根9份、猫儿眼睛12份、梦花根15份、西藏鸡爪草12份、针筒线6份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年1月-2009年12月间共收集80例毒性弥漫性甲状腺肿门诊和住院患者，年龄20-65岁，病程1-2年。随机分为：治疗组40例，对照组40例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程2个月。
2.2对照组口服他巴唑，10mg/次，每天3次。疗程2个月。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：自觉症状消失，甲状腺恢复正常大小，血清总T4、T3，游离T4、T3，血清促甲状腺激素(TSH)恢复正常。显效：自觉症状消失，甲状腺缩小超过1度，血清总T4、T3，游离T4、T3和血清TSH中有3项恢复正常者。有效：自觉症状明显减轻，甲状腺虽有缩小但未超过1度，血清总T4、T3，游离T4、T3和血清TSH中有1项恢复正常者。无效：自觉症状、甲状腺肿大等无好转，上述指标无一项恢复正常者。
3.2治疗统计结果见表1。
表1两组疗效比较
可见，本发明制得的药物能够安全有效治疗毒性弥漫性甲状腺肿。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：乌鱼刺10克、红陈艾15克、朴松实10克、屈头鸡9克、石椒草10克、厚叶子树15克、打米花15克、滴血根9克、猫儿眼睛12克、梦花根15克、西藏鸡爪草12克、针筒线6克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗毒性弥漫性甲状腺肿。口服，每日分早晚两次服用。
具体实施例2
称取：乌鱼刺10克、红陈艾15克、朴松实10克、屈头鸡9克、石椒草10克、厚叶子树15克、打米花15克、滴血根9克、猫儿眼睛12克、梦花根15克、西藏鸡爪草12克、针筒线6克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗毒性弥漫性甲状腺肿。口服，每日分早晚两次服用。
具体实施例3
称取：乌鱼刺10克、红陈艾15克、朴松实10克、屈头鸡9克、石椒草10克、厚叶子树15克、打米花15克、滴血根9克、猫儿眼睛12克、梦花根15克、西藏鸡爪草12克、针筒线6克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗毒性弥漫性甲状腺肿。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗毒性弥漫性甲状腺肿的中药，其特征在于，由以下重量配比的药材制备而成：乌鱼刺10份、红陈艾15份、朴松实10份、屈头鸡9份、石椒草10份、厚叶子树15份、打米花15份、滴血根9份、猫儿眼睛12份、梦花根15份、西藏鸡爪草12份、针筒线6份。
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