CN103524618A - 促红细胞生成素受体结合抗体 - Google Patents

促红细胞生成素受体结合抗体 Download PDF

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Publication number
CN103524618A
CN103524618A CN201110126552.3A CN201110126552A CN103524618A CN 103524618 A CN103524618 A CN 103524618A CN 201110126552 A CN201110126552 A CN 201110126552A CN 103524618 A CN103524618 A CN 103524618A
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CN
China
Prior art keywords
antibody
seq
sequence
variable region
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201110126552.3A
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English (en)
Chinese (zh)
Inventor
P·J·达里埃斯
L·L·格琳
D·H·欧斯罗
E·B·雷利
J·韦勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Abbott Laboratories
Original Assignee
Abbott GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/269,711 external-priority patent/US20040071694A1/en
Priority claimed from US10/684,109 external-priority patent/US7396913B2/en
Application filed by Abbott GmbH and Co KG filed Critical Abbott GmbH and Co KG
Publication of CN103524618A publication Critical patent/CN103524618A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201110126552.3A 2002-10-14 2003-10-14 促红细胞生成素受体结合抗体 Pending CN103524618A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/269711 2002-10-14
US10/269,711 US20040071694A1 (en) 2002-10-14 2002-10-14 Erythropoietin receptor binding antibodies
US10/684109 2003-10-10
US10/684,109 US7396913B2 (en) 2002-10-14 2003-10-10 Erythropoietin receptor binding antibodies

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2003801060796A Division CN101027322B (zh) 2002-10-14 2003-10-14 促红细胞生成素受体结合抗体

Publications (1)

Publication Number Publication Date
CN103524618A true CN103524618A (zh) 2014-01-22

Family

ID=32109805

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201110126552.3A Pending CN103524618A (zh) 2002-10-14 2003-10-14 促红细胞生成素受体结合抗体

Country Status (13)

Country Link
EP (1) EP1578779A4 (ko)
JP (2) JP4411472B2 (ko)
KR (1) KR20050059263A (ko)
CN (1) CN103524618A (ko)
AU (2) AU2003282588B2 (ko)
BR (1) BR0315275A (ko)
CA (1) CA2501984C (ko)
MX (1) MXPA05003997A (ko)
NZ (1) NZ539263A (ko)
PL (1) PL379985A1 (ko)
TW (1) TWI320716B (ko)
WO (1) WO2004035603A2 (ko)
ZA (1) ZA201004902B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105542006A (zh) * 2015-12-11 2016-05-04 北京大学第一医院 抗epor融合蛋白抗体的制备方法和用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105542006A (zh) * 2015-12-11 2016-05-04 北京大学第一医院 抗epor融合蛋白抗体的制备方法和用途

Also Published As

Publication number Publication date
EP1578779A4 (en) 2011-11-16
TW200418505A (en) 2004-10-01
BR0315275A (pt) 2005-08-30
WO2004035603A2 (en) 2004-04-29
WO2004035603A3 (en) 2006-04-27
ZA201004902B (en) 2012-06-27
JP2006523083A (ja) 2006-10-12
JP2009149665A (ja) 2009-07-09
MXPA05003997A (es) 2005-06-22
CA2501984C (en) 2011-04-26
TWI320716B (en) 2010-02-21
NZ539263A (en) 2009-07-31
EP1578779A2 (en) 2005-09-28
CA2501984A1 (en) 2004-04-29
AU2003282588A1 (en) 2004-05-04
KR20050059263A (ko) 2005-06-17
PL379985A1 (pl) 2006-11-27
JP4411472B2 (ja) 2010-02-10
AU2003282588B2 (en) 2010-06-03
AU2010214778A1 (en) 2010-09-23

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Application publication date: 20140122