CN103520284B - 一种酶辅助制备兽用双黄连口服液的方法 - Google Patents
一种酶辅助制备兽用双黄连口服液的方法 Download PDFInfo
- Publication number
- CN103520284B CN103520284B CN201310444915.7A CN201310444915A CN103520284B CN 103520284 B CN103520284 B CN 103520284B CN 201310444915 A CN201310444915 A CN 201310444915A CN 103520284 B CN103520284 B CN 103520284B
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- CN
- China
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- oral liquid
- gained
- shuanghuanglian oral
- livestock
- medicinal liquid
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007788 liquid Substances 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 title claims abstract description 28
- 239000009254 shuang-huang-lian Substances 0.000 title claims abstract description 21
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 13
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 7
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 7
- 239000012535 impurity Substances 0.000 claims abstract description 6
- 244000144972 livestock Species 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 229940088598 enzyme Drugs 0.000 claims description 11
- 241000628997 Flos Species 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 8
- 239000012567 medical material Substances 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 8
- 108010059892 Cellulase Proteins 0.000 claims description 7
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 claims description 7
- 229940106157 cellulase Drugs 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 241000411851 herbal medicine Species 0.000 claims description 3
- 230000002779 inactivation Effects 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000010792 warming Methods 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 9
- 238000000605 extraction Methods 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 238000005516 engineering process Methods 0.000 abstract description 5
- 238000000746 purification Methods 0.000 abstract description 3
- 238000004090 dissolution Methods 0.000 abstract description 2
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- 206010007247 Carbuncle Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
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- 231100000614 poison Toxicity 0.000 description 3
- 239000002351 wastewater Substances 0.000 description 3
- 208000015220 Febrile disease Diseases 0.000 description 2
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 description 2
- 240000004534 Scutellaria baicalensis Species 0.000 description 2
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 description 2
- 229960003321 baicalin Drugs 0.000 description 2
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000208828 Caprifoliaceae Species 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000555682 Forsythia x intermedia Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 241000827798 Hemerocallis citrina Species 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 241000557133 Hunnemannia fumariifolia Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000003916 acid precipitation Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000000703 high-speed centrifugation Methods 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
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CN201310444915.7A CN103520284B (zh) | 2013-09-27 | 2013-09-27 | 一种酶辅助制备兽用双黄连口服液的方法 |
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CN201310444915.7A CN103520284B (zh) | 2013-09-27 | 2013-09-27 | 一种酶辅助制备兽用双黄连口服液的方法 |
Publications (2)
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CN103520284A CN103520284A (zh) | 2014-01-22 |
CN103520284B true CN103520284B (zh) | 2014-12-31 |
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Families Citing this family (2)
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CN106511484B (zh) * | 2016-12-07 | 2019-07-05 | 洛阳君山制药有限公司 | 一种复方金银花颗粒的提取制备工艺 |
CN109550006A (zh) * | 2018-11-16 | 2019-04-02 | 怀化学院 | 洁阴止痒洗液的除杂方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101759259A (zh) * | 2008-10-30 | 2010-06-30 | 天津生机集团股份有限公司 | 用于水产动物养殖的双黄连口服液及其制备方法 |
CN102977164A (zh) * | 2012-11-05 | 2013-03-20 | 河南牧翔动物药业有限公司 | 一种刺五加叶中金丝桃苷的酶辅助提取工艺 |
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- 2013-09-27 CN CN201310444915.7A patent/CN103520284B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101759259A (zh) * | 2008-10-30 | 2010-06-30 | 天津生机集团股份有限公司 | 用于水产动物养殖的双黄连口服液及其制备方法 |
CN102977164A (zh) * | 2012-11-05 | 2013-03-20 | 河南牧翔动物药业有限公司 | 一种刺五加叶中金丝桃苷的酶辅助提取工艺 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A method for enzyme assisted preparation of Shuanghuanglian oral liquid for animals Effective date of registration: 20211224 Granted publication date: 20141231 Pledgee: China Construction Bank Corporation Zhengzhou Railway Sub Branch Pledgor: HENAN SOAR VETERINARY PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016170 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20141231 Pledgee: China Construction Bank Corporation Zhengzhou Railway Sub Branch Pledgor: HENAN SOAR VETERINARY PHARMACEUTICAL Co.,Ltd.|HENAN MUXIANG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2021980016170 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A Method for Enzymatic Assisted Preparation of Animal Shuanghuanglian Oral Liquid Granted publication date: 20141231 Pledgee: China Construction Bank Corporation Zhengzhou Railway Sub Branch Pledgor: HENAN SOAR VETERINARY PHARMACEUTICAL Co.,Ltd.|HENAN MUXIANG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2024980004821 |
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Address after: No. 9, Yugang Road, Airport Economic Comprehensive Experimental Zone, Zhengzhou City, Henan Province, 451162 Patentee after: Henan Muxiang Biotechnology Co.,Ltd. Country or region after: China Address before: 451162 airport road five, Zhengzhou, Henan Patentee before: HENAN SOAR VETERINARY PHARMACEUTICAL Co.,Ltd. Country or region before: China |
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