CN103517981B - 具有粘度改变表型的丝状真菌 - Google Patents
具有粘度改变表型的丝状真菌 Download PDFInfo
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- CN103517981B CN103517981B CN201280019432.6A CN201280019432A CN103517981B CN 103517981 B CN103517981 B CN 103517981B CN 201280019432 A CN201280019432 A CN 201280019432A CN 103517981 B CN103517981 B CN 103517981B
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- gene
- tps2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478162P | 2011-04-22 | 2011-04-22 | |
| US201161478160P | 2011-04-22 | 2011-04-22 | |
| US61/478,162 | 2011-04-22 | ||
| US61/478,160 | 2011-04-22 | ||
| US201161480629P | 2011-04-29 | 2011-04-29 | |
| US201161480610P | 2011-04-29 | 2011-04-29 | |
| US201161480602P | 2011-04-29 | 2011-04-29 | |
| US61/480,602 | 2011-04-29 | ||
| US61/480,610 | 2011-04-29 | ||
| US61/480,629 | 2011-04-29 | ||
| PCT/US2012/034409 WO2012145598A1 (fr) | 2011-04-22 | 2012-04-20 | Champignons filamenteux présentant un phénotype viscosité modifié |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103517981A CN103517981A (zh) | 2014-01-15 |
| CN103517981B true CN103517981B (zh) | 2017-02-15 |
Family
ID=46018122
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280019432.6A Active CN103517981B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
| CN201280019710.8A Active CN103502266B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
| CN201280019665.6A Active CN103502430B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280019710.8A Active CN103502266B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
| CN201280019665.6A Active CN103502430B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9868958B2 (fr) |
| EP (3) | EP2673290B1 (fr) |
| JP (3) | JP6042870B2 (fr) |
| KR (3) | KR20140033047A (fr) |
| CN (3) | CN103517981B (fr) |
| AU (4) | AU2012245319A1 (fr) |
| BR (3) | BR112013026535A2 (fr) |
| CA (3) | CA2833539C (fr) |
| DK (3) | DK2699668T3 (fr) |
| WO (3) | WO2012145598A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2699588B1 (fr) * | 2011-04-22 | 2016-11-30 | Danisco US Inc. | Champignons filamenteux présentant un phénotype de viscosité modifié |
| US9868958B2 (en) * | 2011-04-22 | 2018-01-16 | Danisco Us Inc. | Filamentous fungi having an altered viscosity phenotype |
| US20150275222A1 (en) * | 2012-10-22 | 2015-10-01 | Bo Jiang | Crz1 mutant fungal cells |
| KR20200026878A (ko) | 2017-06-06 | 2020-03-11 | 지머젠 인코포레이티드 | 균류 균주를 개량하기 위한 htp 게놈 공학 플랫폼 |
| US11976266B2 (en) | 2018-04-24 | 2024-05-07 | Danisco Us Inc. | Filamentous fungal strains comprising reduced viscosity phenotypes |
| WO2019236848A1 (fr) | 2018-06-06 | 2019-12-12 | Zymergen Inc. | Manipulation de gènes impliqués dans la transduction de signal pour réguler la morphologie fongique pendant la fermentation et la production |
| EP3801554A4 (fr) * | 2018-06-08 | 2022-06-08 | Emergy Inc. | Procédés de mise en culture de mycélium fongique et de formation de produits comestibles à partir de celui-ci |
| US12116605B2 (en) | 2018-07-30 | 2024-10-15 | Danisco Us Inc. | Mutant and genetically modified filamentous fungal strains comprising enhanced protein productivity phenotypes and methods thereof |
| BR112021001743A2 (pt) | 2018-07-30 | 2021-04-27 | Toray Industries, Inc. | cepas mutantes de um fungo filamentoso do gênero trichoderma e métodos para a produção de uma proteína e para a produção de uma celulase |
| US20210388410A1 (en) * | 2018-10-11 | 2021-12-16 | Toray Industries, Inc. | Mutant strain of trichoderma reesei, and protein manufacturing method |
| US20200354756A1 (en) * | 2019-04-03 | 2020-11-12 | Danisco Us Inc | Disruption of mvb12 in yeast is associated with increased alcohol production and tolerance |
| FR3104169B1 (fr) * | 2019-12-04 | 2022-10-21 | Ifp Energies Now | Souche de champignon ayant une viscosite diminuee |
| US20220396817A1 (en) * | 2020-02-14 | 2022-12-15 | Inbiose N.V. | Production of glycosylated product in host cells |
| EP3926039A1 (fr) | 2020-06-17 | 2021-12-22 | AB Enzymes GmbH | Utilisation d'une nucléase pour réduire la viscosité et/ou empêcher une augmentation de la viscosité d'un bouillon de fermentation |
| US11479779B2 (en) | 2020-07-31 | 2022-10-25 | Zymergen Inc. | Systems and methods for high-throughput automated strain generation for non-sporulating fungi |
| CN111944779B (zh) * | 2020-08-28 | 2022-06-21 | 山东省科学院生物研究所 | 一种海藻糖合成双功能酶编码基因TvTPS/TPP及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159833A (zh) * | 1994-06-29 | 1997-09-17 | 阿尔科集团公司 | 产生海藻糖的转基因植物 |
| CN1380905A (zh) * | 2000-04-13 | 2002-11-20 | 马克·阿龙·埃马尔法尔布 | 丝状真菌中dna表达文库的高通量筛选 |
| WO2007099749A1 (fr) * | 2006-02-28 | 2007-09-07 | Suntory Limited | Gène codant pour la tréhalose-6-phosphate phosphatase et applications |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7189538B2 (en) | 1999-03-24 | 2007-03-13 | Genencor International, Inc. | Hyphal growth in fungi |
| CA2378016A1 (fr) | 1999-07-30 | 2001-02-08 | Margreet Heerikhuisen | Nouveaux moyens de transformation de champignons et leur utilisation pour la production d'une proteine heterologue |
| EP1854888A3 (fr) * | 2000-04-13 | 2009-10-07 | Dyadic International (USA), Inc. | Séquences de régulation de l'expression et produits de l'expression dans le domaine des champignons filamenteux |
| AU2002303138A1 (en) | 2001-03-14 | 2002-10-15 | Genencor International, Inc. | Regulatable growth of filamentous fungi |
| DE60308354T2 (de) * | 2002-05-03 | 2007-09-06 | Dsm Ip Assets B.V. | Prozess für die kontrolle der kontaminationsbeseitigung während des reinigungsprozesses eines durch eine wirtszelle produzierten arzneimittels |
| CA2525333C (fr) | 2003-05-29 | 2016-03-01 | Genencor International, Inc. | Genes de trichoderma |
| JP4834554B2 (ja) * | 2003-11-06 | 2011-12-14 | ジェネンコー・インターナショナル・インク | 糸状菌におけるプロテアーゼ抑制剤及びその変異体の発現 |
| KR102004003B1 (ko) | 2010-08-25 | 2019-07-25 | 다니스코 유에스 인크. | 변경된 점성 표현형을 갖는 사상균 |
| US9868958B2 (en) * | 2011-04-22 | 2018-01-16 | Danisco Us Inc. | Filamentous fungi having an altered viscosity phenotype |
| EP2699588B1 (fr) * | 2011-04-22 | 2016-11-30 | Danisco US Inc. | Champignons filamenteux présentant un phénotype de viscosité modifié |
-
2012
- 2012-04-20 US US14/113,549 patent/US9868958B2/en active Active
- 2012-04-20 AU AU2012245319A patent/AU2012245319A1/en not_active Abandoned
- 2012-04-20 JP JP2014506567A patent/JP6042870B2/ja active Active
- 2012-04-20 KR KR1020137030475A patent/KR20140033047A/ko not_active Application Discontinuation
- 2012-04-20 JP JP2014506564A patent/JP6042867B2/ja active Active
- 2012-04-20 AU AU2012245323A patent/AU2012245323B2/en not_active Ceased
- 2012-04-20 WO PCT/US2012/034409 patent/WO2012145598A1/fr active Application Filing
- 2012-04-20 JP JP2014506566A patent/JP6042869B2/ja active Active
- 2012-04-20 EP EP12717558.6A patent/EP2673290B1/fr active Active
- 2012-04-20 EP EP12717561.0A patent/EP2699668B1/fr active Active
- 2012-04-20 WO PCT/US2012/034399 patent/WO2012145592A1/fr active Application Filing
- 2012-04-20 BR BR112013026535A patent/BR112013026535A2/pt not_active Application Discontinuation
- 2012-04-20 KR KR1020137030515A patent/KR101952469B1/ko active IP Right Grant
- 2012-04-20 DK DK12717561.0T patent/DK2699668T3/en active
- 2012-04-20 CA CA2833539A patent/CA2833539C/fr active Active
- 2012-04-20 US US14/113,799 patent/US9593341B2/en active Active
- 2012-04-20 CN CN201280019432.6A patent/CN103517981B/zh active Active
- 2012-04-20 DK DK12717560.2T patent/DK2699667T3/en active
- 2012-04-20 KR KR1020137030474A patent/KR101952467B1/ko active IP Right Grant
- 2012-04-20 CN CN201280019710.8A patent/CN103502266B/zh active Active
- 2012-04-20 EP EP12717560.2A patent/EP2699667B1/fr active Active
- 2012-04-20 AU AU2012245325A patent/AU2012245325B2/en not_active Ceased
- 2012-04-20 CN CN201280019665.6A patent/CN103502430B/zh active Active
- 2012-04-20 BR BR112013026559A patent/BR112013026559A2/pt not_active Application Discontinuation
- 2012-04-20 CA CA2833765A patent/CA2833765C/fr active Active
- 2012-04-20 BR BR112013025434A patent/BR112013025434A2/pt not_active Application Discontinuation
- 2012-04-20 CA CA2833756A patent/CA2833756C/fr active Active
- 2012-04-20 DK DK12717558.6T patent/DK2673290T3/en active
- 2012-04-20 WO PCT/US2012/034405 patent/WO2012145596A1/fr active Application Filing
- 2012-04-20 US US14/113,930 patent/US9587242B2/en active Active
-
2017
- 2017-09-28 AU AU2017235968A patent/AU2017235968B2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159833A (zh) * | 1994-06-29 | 1997-09-17 | 阿尔科集团公司 | 产生海藻糖的转基因植物 |
| CN1380905A (zh) * | 2000-04-13 | 2002-11-20 | 马克·阿龙·埃马尔法尔布 | 丝状真菌中dna表达文库的高通量筛选 |
| WO2007099749A1 (fr) * | 2006-02-28 | 2007-09-07 | Suntory Limited | Gène codant pour la tréhalose-6-phosphate phosphatase et applications |
Non-Patent Citations (2)
| Title |
|---|
| The orlA gene from Aspergillus nidulans encodes a trehalose-6-phosphate phosphatase necessary for normal growth and chitin synthesis at elevated temperatures;Peter T. Borgia 等;《Molecular Microbiology》;19961231;第20卷(第6期);第1287页右栏，第1290页右栏，第1293页左栏第3段、右栏第1段，第1294页左栏第3段 * |
| 球孢白僵菌tps2基因的克隆和生物信息学分析;谢翎 等;《激光生物学报》;20100630;第19卷(第3期);363-372 * |
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| CN103517981B (zh) | 具有粘度改变表型的丝状真菌 | |
| CN103502431B (zh) | 具有粘度改变表型的丝状真菌 | |
| US10266832B2 (en) | Filamentous fungi having an altered viscosity phenotype |
Legal Events
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |