CN103478710B - 左旋肉碱微囊粉及其制备方法 - Google Patents
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Abstract
一种左旋肉碱微囊粉及其制备方法，所述左旋肉碱微囊粉包括：左旋肉碱，麦芽糊精，阿拉伯胶，明胶，抗坏血酸钠。所述制备方法包括以下步骤：1）称取5%质量百分比的明胶，加入到水中，溶胀1小时左右，升温到45℃，搅拌，至明胶完全溶解，再加入4%质量百分比的阿拉伯胶与4%质量百分比的麦芽糊精到明胶溶液中，搅拌，使其溶解，最终得到包材溶液；2）将85%质量百分比的左旋肉碱、1%质量百分比的抗坏血酸钠、1%质量百分比的磷酸三钙加入到所述包材溶液中，搅拌，使其充分溶解，混合均匀，得到包埋液；3）将包埋液用喷雾干燥塔进行喷雾干燥，得到微囊化类左旋肉碱粉。本发明的左旋肉碱微囊粉及其制备方法，将具有强吸水特性的左旋肉碱用包材进行包埋，增强了其稳定性，而且制备工艺更加绿色环保。
Description
技术领域
本发明涉及一种左旋肉碱，尤其涉及一种左旋肉碱微囊粉及其制备方法。
背景技术
左旋肉碱 (L-carnitine)，又称L-肉碱，是一种促使脂肪转化为能量的类氨基酸，红色肉类是左旋肉碱的主要来源，对人体无毒副作用。左旋肉碱是脂肪代谢过程中的一种关键的物质，能够促进脂肪酸进入线粒体氧化分解。可以说左旋肉碱是转运脂肪酸的载体。在长时间大强度运动中，左旋肉碱提高了脂肪的氧化速率，减少了糖原的消耗，同时也延缓了疲劳，目前人们已把它应用于大众减肥、竞技运动员减脂抗疲劳，经多年观察，效果明显。目前左旋肉碱已应用于医药、保健和食品等领域，并已被瑞士、法国、美国和世界卫生组织规定为法定的多用途营养剂。我国于1996年正式将左旋肉碱列入营养强化剂，允许在饮料、乳饮料、饼干、乳粉中添加左旋肉碱。
但目前市场上很少有直接将纯左旋肉碱应用于这类产品中，这是因为纯左旋肉碱吸湿性太强易结块变质，人们一般是将其制作成左旋肉碱盐及其衍生物，如左旋肉碱酒石酸盐，左旋肉碱富马酸盐，左旋肉碱盐酸盐，乙酰左旋肉碱等。关于这方面的研究报告国内外也有很多，如中国专利（CN 1349976A）制备左旋肉碱酒石酸盐，中国专利（CN 101209975A）制备左旋肉碱富马酸钙，国际上的方法如美国专利（4,602,039左旋肉碱酒石酸盐），（5,703,376 左旋肉碱富马酸盐）。通过这些方法制备得到的左旋肉碱的衍生物相比于左旋肉碱，更加稳定，在运输、保持、使用过程中不易吸潮，但会有一些特征风味，同时产品中含有的左旋肉碱有效含量均偏低：左旋肉碱酒石酸盐约为55%，左旋肉碱富马酸盐约为58%，更重要的是将左旋肉碱制备成盐的过程涉及相关化学反应，需要用到相关化学试剂，在工业化生产中需要控制工艺，处理污水等相关质量环境因素，虽然最终能得到稳定性较好的左旋肉碱衍生物，但过程过于繁琐。
本发明采用制备微囊粉的方法，将纯左旋肉碱晶体通过喷雾干燥的方法，选择合适的包材将其制备成左旋肉碱微囊粉，可以有效包埋左旋肉碱，形成保护层，将左旋肉碱与外界环境隔绝，解决其吸湿性过强的问题，同时产品中左旋肉碱的有效含量在80%以上，远高于左旋肉碱盐类，整个过程简单，不涉及化学反应及污水处理，环境友好。
发明内容
本发明的目的在于提供一种左旋肉碱微囊粉及其制备方法，可以明显改善左旋肉碱的强吸湿性，工艺更加简单、高效。
为了实现上述目的，本发明的提供的左旋肉碱微囊粉，包括：包括左旋肉碱，麦芽糊精，阿拉伯胶，明胶，抗坏血酸钠，磷酸三钙。
其中，按质量百分比，所述左旋肉碱85%，麦芽糊精4%，阿拉伯胶4%，明胶5%，抗坏血酸钠1%，磷酸三钙1%。
为了实现上述目的，本发明的提供的左旋肉碱微囊粉制备方法，包括以下步骤：
1）称取5%质量百分比的明胶，加入到水中，溶胀1小时左右，升温到45℃，搅拌，至明胶完全溶解，再加入4%质量百分比的阿拉伯胶与4%质量百分比的麦芽糊精到明胶溶液中，搅拌，使其溶解，最终得到包材溶液；
2）将85%质量百分比的左旋肉碱、1%质量百分比的抗坏血酸钠、1%质量百分比的磷酸三钙加入到所述包材溶液中，搅拌，使其充分溶解，混合均匀，得到包埋液；
3）将包埋液用喷雾干燥塔进行喷雾干燥，得到微囊化类左旋肉碱粉。
其中，所述喷雾干燥的条件为：进风口温度为160-190℃，出风口温度70-100℃，料液流速控制在5-30mL/s。
采用本方法制得的左旋肉碱微囊粉，包埋率大于90%，其大小为60目左右。
本发明的左旋肉碱微囊粉及其制备方法，将具有强吸水特性的左旋肉碱用包材进行包埋，有效隔绝了其与外界环境的联系，增强了其稳定性，与本领域现有技术相比，本发明简单、高效，不涉及制备左旋肉碱盐及其衍生物过程中所用的化学反应，带来的污水处理等问题，整个过程更加绿色环保。
具体实施方式
为了更好的解释本发明，下面结合具体实施例对本发明作进一步说明。下列实施例中所述的材料和试剂，如无特殊说明均可从商业途径获得，实施例中的“%”代表质量百分比。
微囊化左旋肉碱，以重量计，包括以下组份：
左旋肉碱纯品 85%
麦芽糊精 4% 阿拉伯胶 4%
明胶 5%
抗坏血酸钠 1%
磷酸三钙 1%
微囊化左旋肉碱，其制备工艺为：
首先，将50g明胶加入到1500g水中，溶胀1小时后，升温到45℃，搅拌使其完全溶解，再加入40g阿拉伯胶和40g麦芽糊精到溶液中，搅拌使其完全溶解，得到包材溶液。
其次，将850g左旋肉碱纯品，10g抗坏血酸钠和10g磷酸三钙依次加入到包材溶液中，充分搅拌使其混合均匀，得到包埋液。
最后，将包埋液用喷雾干燥塔进行喷雾干燥，喷雾干燥条件为：进风口温度为170℃，出风口温度90℃，料液流速控制在10mL/s。
本领域普通技术人员可以理解：以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (2)
1.一种左旋肉碱微囊粉的制备方法，其特征在于，包括以下步骤：
1）称取5%质量百分比的明胶，加入到水中，溶胀1小时左右，升温到45℃，搅拌，至明胶完全溶解，再加入4%质量百分比的阿拉伯胶与4%质量百分比的麦芽糊精到明胶溶液中，搅拌，使其溶解，最终得到包材溶液；
2）将85%质量百分比的左旋肉碱、1%质量百分比的抗坏血酸钠、1%质量百分比的磷酸三钙加入到所述包材溶液中，搅拌，使其充分溶解，混合均匀，得到包埋液；
3）将包埋液用喷雾干燥塔进行喷雾干燥，得到微囊化类左旋肉碱粉。
2.根据权利要求1所述的制备方法，其特征在于，所述喷雾干燥的条件为：进风口温度为160-190℃，出风口温度70-100℃，料液流速控制在5-30mL/s。
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| CN101057636A (zh) * | 2007-05-14 | 2007-10-24 | 广东工业大学 | 一种耐受水分食品微胶囊的生产方法 |
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