WO2015027565A1 - 左旋肉碱微囊粉及其制备方法 - Google Patents
左旋肉碱微囊粉及其制备方法 Download PDFInfo
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- WO2015027565A1 WO2015027565A1 PCT/CN2013/086400 CN2013086400W WO2015027565A1 WO 2015027565 A1 WO2015027565 A1 WO 2015027565A1 CN 2013086400 W CN2013086400 W CN 2013086400W WO 2015027565 A1 WO2015027565 A1 WO 2015027565A1
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- Prior art keywords
- carnitine
- gelatin
- mass
- solution
- maltodextrin
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- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims abstract description 58
- 239000000843 powder Substances 0.000 title claims abstract description 20
- 239000003094 microcapsule Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 108010010803 Gelatin Proteins 0.000 claims abstract description 17
- 239000008273 gelatin Substances 0.000 claims abstract description 17
- 229920000159 gelatin Polymers 0.000 claims abstract description 17
- 235000019322 gelatine Nutrition 0.000 claims abstract description 17
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 17
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 11
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 11
- 235000010489 acacia gum Nutrition 0.000 claims abstract description 11
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 11
- 235000010378 sodium ascorbate Nutrition 0.000 claims abstract description 11
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims abstract description 11
- 229960005055 sodium ascorbate Drugs 0.000 claims abstract description 11
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims abstract description 11
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 10
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 10
- 235000019731 tricalcium phosphate Nutrition 0.000 claims abstract description 10
- 229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 10
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000005022 packaging material Substances 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 16
- 229920000084 Gum arabic Polymers 0.000 claims description 8
- 241000978776 Senegalia senegal Species 0.000 claims description 8
- 239000000205 acacia gum Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 229940014259 gelatin Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000008961 swelling Effects 0.000 abstract description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 abstract 3
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 230000008569 process Effects 0.000 description 8
- RZALONVQKUWRRY-FYZOBXCZSA-N 2,3-dihydroxybutanedioic acid;(3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound OC(=O)C(O)C(O)C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O RZALONVQKUWRRY-FYZOBXCZSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- HNSUOMBUJRUZHJ-REVJHSINSA-N [(2r)-3-carboxy-2-hydroxypropyl]-trimethylazanium;(z)-4-hydroxy-4-oxobut-2-enoate Chemical compound OC(=O)\C=C/C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O HNSUOMBUJRUZHJ-REVJHSINSA-N 0.000 description 3
- 239000010865 sewage Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical group 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- JXXCENBLGFBQJM-UHFFFAOYSA-N (3-carboxy-2-hydroxypropyl)-trimethylazanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC(O)CC(O)=O JXXCENBLGFBQJM-UHFFFAOYSA-N 0.000 description 1
- BQMPVGMHZKZPBH-BYZBDTJCSA-N (3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O.C[N+](C)(C)C[C@H](O)CC([O-])=O BQMPVGMHZKZPBH-BYZBDTJCSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- KTUYNMKITNGXTP-UNKACTGFSA-L calcium;(e)-but-2-enedioate;(3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound [Ca+2].[O-]C(=O)\C=C\C([O-])=O.C[N+](C)(C)C[C@H](O)CC([O-])=O KTUYNMKITNGXTP-UNKACTGFSA-L 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000006864 oxidative decomposition reaction Methods 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 235000020989 red meat Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/25—Exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the invention relates to a L-carnitine, in particular to a L-carnitine microcapsule powder and a preparation method thereof.
- L-carnitine also known as L-carnitine
- L-carnitine is an amino acid that promotes the conversion of fat into energy. Red meat is the main source of L-carnitine and has no toxic side effects on human body.
- L-carnitine is a key substance in the process of fat metabolism, which can promote the oxidative decomposition of fatty acids into mitochondria. It can be said that L-carnitine is a carrier for transporting fatty acids.
- L-carnitine increases the oxidation rate of fat, reduces the consumption of glycogen, and also delays fatigue. At present, it has been applied to mass loss, athletes to reduce fat and fatigue, after many years. Observed, the effect is obvious.
- L-carnitine has been used in the fields of medicine, health care and food, and has been regulated as a legal multi-purpose nutrient by Switzerland, France, the United States and the World Health Organization. In 1996, China officially listed L-carnitine as a nutritional supplement, allowing L-carnitine to be added to beverages, milk drinks, biscuits and milk powder.
- L-carnitines there are few direct L-carnitines directly applied to such products on the market. This is because pure L-carnitine is too hygroscopic to be agglomerated and deteriorated. People generally make L-carnitine salts and their derivatives. Such as L-carnitine tartrate, L-carnitine fumarate, L-carnitine hydrochloride, acetyl L-carnitine and the like.
- the invention adopts the method for preparing microcapsule powder, and prepares the L-carnitine microcapsule powder by spraying the pure L-carnitine crystal by spray drying method, and can effectively embed L-carnitine to form a protective layer.
- L-carnitine is isolated from the external environment to solve the problem of excessive hygroscopicity.
- the effective content of L-carnitine in the product is above 80%, which is much higher than that of L-carnitine.
- the whole process is simple and does not involve chemical reactions. Sewage treatment, environmentally friendly.
- the object of the present invention is to provide a L-carnitine microcapsule powder and a preparation method thereof, which can obviously improve the strong hygroscopicity of L-carnitine, and the process is simpler and more efficient.
- the L-carnitine microcapsule powder provided by the present invention comprises: L-carnitine, maltodextrin, gum arabic, gelatin, sodium ascorbate, and tricalcium phosphate.
- the method for preparing a L-carnitine microcapsule powder comprises the following steps:
- the conditions of the spray drying are: the inlet air temperature is 160-190 ° C, the air outlet temperature is 70-100 ° C, and the feed liquid flow rate is controlled at 5-30 mL/s.
- the L-carnitine microcapsule powder prepared by the method has an embedding rate of more than 90% and a size of about 60 mesh.
- the invention is simple and efficient, and does not involve the chemical reaction used in the process of preparing the L-carnitine salt and its derivatives, and the sewage treatment and the like, and the whole process is more green and environmentally friendly.
- Microencapsulated L-carnitine by weight, includes the following components:
- Microencapsulated L-carnitine the preparation process is:
- the embedding solution was spray-dried with a spray drying tower under the conditions of an air inlet temperature of 170 ° C, an outlet temperature of 90 ° C, and a feed liquid flow rate of 10 mL/s.
Abstract
一种左旋肉碱微囊粉及其制备方法，所述左旋肉碱微囊粉包括：左旋肉碱，麦芽糊精，阿拉伯胶，明胶，抗坏血酸钠。所述制备方法包括以下步骤：1）称取5%质量百分比的明胶，加入到水中，溶胀1小时左右，升温到45℃，搅拌，至明胶完全溶解，再加入4%质量百分比的阿拉伯胶与4%质量百分比的麦芽糊精到明胶溶液中，搅拌，使其溶解，最终得到包材溶液；2）将85%质量百分比的左旋肉碱、1%质量百分比的抗坏血酸钠、1%质量百分比的磷酸三钙加入到所述包材溶液中，搅拌，使其充分溶解，混合均匀，得到包埋液；3）将包埋液用喷雾干燥塔进行喷雾干燥，得到微囊化类左旋肉碱粉。本发明的左旋肉碱微囊粉及其制备方法，将具有强吸水特性的左旋肉碱用包材进行包埋，增强了其稳定性，而且制备工艺更加绿色环保。
Description
本发明涉及一种左旋肉碱，尤其涉及一种左旋肉碱微囊粉及其制备方法。
左旋肉碱
(L-carnitine)，又称L-肉碱，是一种促使脂肪转化为能量的类氨基酸，红色肉类是左旋肉碱的主要来源，对人体无毒副作用。左旋肉碱是脂肪代谢过程中的一种关键的物质，能够促进脂肪酸进入线粒体氧化分解。可以说左旋肉碱是转运脂肪酸的载体。在长时间大强度运动中，左旋肉碱提高了脂肪的氧化速率，减少了糖原的消耗，同时也延缓了疲劳，目前人们已把它应用于大众减肥、竞技运动员减脂抗疲劳，经多年观察，效果明显。目前左旋肉碱已应用于医药、保健和食品等领域，并已被瑞士、法国、美国和世界卫生组织规定为法定的多用途营养剂。我国于1996年正式将左旋肉碱列入营养强化剂，允许在饮料、乳饮料、饼干、乳粉中添加左旋肉碱。
但目前市场上很少有直接将纯左旋肉碱应用于这类产品中，这是因为纯左旋肉碱吸湿性太强易结块变质，人们一般是将其制作成左旋肉碱盐及其衍生物，如左旋肉碱酒石酸盐，左旋肉碱富马酸盐，左旋肉碱盐酸盐，乙酰左旋肉碱等。关于这方面的研究报告国内外也有很多，如中国专利（CN
1349976A）制备左旋肉碱酒石酸盐，中国专利（CN
101209975A）制备左旋肉碱富马酸钙，国际上的方法如美国专利（4,602,039左旋肉碱酒石酸盐），（5,703,376
左旋肉碱富马酸盐）。通过这些方法制备得到的左旋肉碱的衍生物相比于左旋肉碱，更加稳定，在运输、保持、使用过程中不易吸潮，但会有一些特征风味，同时产品中含有的左旋肉碱有效含量均偏低：左旋肉碱酒石酸盐约为55%，左旋肉碱富马酸盐约为58%，更重要的是将左旋肉碱制备成盐的过程涉及相关化学反应，需要用到相关化学试剂，在工业化生产中需要控制工艺，处理污水等相关质量环境因素，虽然最终能得到稳定性较好的左旋肉碱衍生物，但过程过于繁琐。
本发明采用制备微囊粉的方法，将纯左旋肉碱晶体通过喷雾干燥的方法，选择合适的包材将其制备成左旋肉碱微囊粉，可以有效包埋左旋肉碱，形成保护层，将左旋肉碱与外界环境隔绝，解决其吸湿性过强的问题，同时产品中左旋肉碱的有效含量在80%以上，远高于左旋肉碱盐类，整个过程简单，不涉及化学反应及污水处理，环境友好。
本发明的目的在于提供一种左旋肉碱微囊粉及其制备方法，可以明显改善左旋肉碱的强吸湿性，工艺更加简单、高效。
为了实现上述目的，本发明的提供的左旋肉碱微囊粉，包括：包括左旋肉碱，麦芽糊精，阿拉伯胶，明胶，抗坏血酸钠，磷酸三钙。
其中，按质量百分比，所述左旋肉碱85%，麦芽糊精4%，阿拉伯胶4%，明胶5%，抗坏血酸钠1%，磷酸三钙1%。
为了实现上述目的，本发明的提供的左旋肉碱微囊粉制备方法，包括以下步骤：
1）称取5%质量百分比的明胶，加入到水中，溶胀1小时左右，升温到45℃，搅拌，至明胶完全溶解，再加入4%质量百分比的阿拉伯胶与4%质量百分比的麦芽糊精到明胶溶液中，搅拌，使其溶解，最终得到包材溶液；
2）将85%质量百分比的左旋肉碱、1%质量百分比的抗坏血酸钠、1%质量百分比的磷酸三钙加入到所述包材溶液中，搅拌，使其充分溶解，混合均匀，得到包埋液；
3）将包埋液用喷雾干燥塔进行喷雾干燥，得到微囊化类左旋肉碱粉。
其中，所述喷雾干燥的条件为：进风口温度为160-190℃，出风口温度70-100℃，料液流速控制在5-30mL/s。
采用本方法制得的左旋肉碱微囊粉，包埋率大于90%，其大小为60目左右。
本发明的左旋肉碱微囊粉及其制备方法，将具有强吸水特性的左旋肉碱用包材进行包埋，有效隔绝了其与外界环境的联系，增强了其稳定性，与本领域现有技术相比，本发明简单、高效，不涉及制备左旋肉碱盐及其衍生物过程中所用的化学反应，带来的污水处理等问题，整个过程更加绿色环保。
为了更好的解释本发明，下面结合具体实施例对本发明作进一步说明。下列实施例中所述的材料和试剂，如无特殊说明均可从商业途径获得，实施例中的“%”代表质量百分比。
微囊化左旋肉碱，以重量计，包括以下组份：
左旋肉碱纯品 85%
麦芽糊精 4% 阿拉伯胶 4%
明胶 5%
抗坏血酸钠 1%
磷酸三钙 1%
微囊化左旋肉碱，其制备工艺为：
首先，将50g明胶加入到1500g水中，溶胀1小时后，升温到45℃，搅拌使其完全溶解，再加入40g阿拉伯胶和40g麦芽糊精到溶液中，搅拌使其完全溶解，得到包材溶液。
其次，将850g左旋肉碱纯品，10g抗坏血酸钠和10g磷酸三钙依次加入到包材溶液中，充分搅拌使其混合均匀，得到包埋液。
最后，将包埋液用喷雾干燥塔进行喷雾干燥，喷雾干燥条件为：进风口温度为170℃，出风口温度90℃，料液流速控制在10mL/s。
本领域普通技术人员可以理解：以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (4)
- 一种左旋肉碱微囊粉，其特征在于，所述左旋肉碱微囊粉，包括左旋肉碱，麦芽糊精，阿拉伯胶，明胶，抗坏血酸钠，磷酸三钙。
- 根据权利要求1所述的左旋肉碱微囊粉，其特征在于，按质量百分比，所述左旋肉碱85%，麦芽糊精4%，阿拉伯胶4%，明胶5%，抗坏血酸钠1%，磷酸三钙1%。
- 一种左旋肉碱微囊粉的制备方法，其特征在于，包括以下步骤：1）称取5%质量百分比的明胶，加入到水中，溶胀1小时左右，升温到45℃，搅拌，至明胶完全溶解，再加入4%质量百分比的阿拉伯胶与4%质量百分比的麦芽糊精到明胶溶液中，搅拌，使其溶解，最终得到包材溶液；2）将85%质量百分比的左旋肉碱、1%质量百分比的抗坏血酸钠、1%质量百分比的磷酸三钙加入到所述包材溶液中，搅拌，使其充分溶解，混合均匀，得到包埋液；3）将包埋液用喷雾干燥塔进行喷雾干燥，得到微囊化类左旋肉碱粉。
- 根据权利要求1所述的制备方法，其特征在于，所述喷雾干燥的条件为：进风口温度为160-190℃，出风口温度70-100℃，料液流速控制在5-30mL/s。
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| CN109820836A (zh) * | 2019-03-22 | 2019-05-31 | 大连医诺生物股份有限公司 | 左旋肉碱缓释微囊粉及其制备方法 |
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