CN103463495B - Drug for treating senile postoperative acute mental disorders - Google Patents
Drug for treating senile postoperative acute mental disorders Download PDFInfo
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- CN103463495B CN103463495B CN201310433148.XA CN201310433148A CN103463495B CN 103463495 B CN103463495 B CN 103463495B CN 201310433148 A CN201310433148 A CN 201310433148A CN 103463495 B CN103463495 B CN 103463495B
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Abstract
The invention relates to a drug for treating senile postoperative acute mental disorders. The drug is prepared from the following substances in proportion by weight: common alstonia bark leaves, herba selaginellae, ophicslcite ophicalcitum, fagopyrum cymosum, fiveleaf akebia fruits, euryale ferox, pummelo peel, celosia cristata, stalactite, folium polygoni tnctorii, seeds of Chinese dodder, grand torreya seeds, litchi, dyosma difformis, eucommia ulmoides, exocarpium benincasae, peucedanum decursivum maxim, tuber fleeceflower stems, chingma abutilon seeds, longan pulp, semen lepidii, soybean germinated, biotite schist and mica, valeriana jatamansi jones, saxifraga stolonifera, spina gleditsiae, folium turpiniae, Chinese honey locust, glechoma longituba, nodular branches of pine, adonis, impatiens balsamina, caulis bambusae in taeniam, desert asparagus, murraya paniculata, saururus chinensis, string beans, leaves of purpleflower holly, veronicastrum herb, Chinese starjasmine stems, abalone, lysionotius pauciflorus maxim, radix ampelopsis, radix scrophulariae, microcos paniculata, dayflowers, fructus piperis longi, corn stigmas, huperzia serrata and amethyst. The drug for treating senile postoperative acute mental disorders disclosed by the invention is prepared from natural medicines, has a clear curative effect, can be used for effectively treating the senile postoperative acute mental disorders, and therefore, the drug is very suitable for clinical application.
Description
Technical field
The present invention relates to psychiatric nursing field, relate in particular to a kind of medicament for the treatment of old postoperative acute mental disorder.
Background technology
Postoperative acute mental disorder refers to a kind of reversibility acute confusion derangement syndrome occurred in Post operation 4-6h, primary disease morbidity is hurried, the cause of disease is still not clear, and main manifestations is the abalienation of the aspects such as cognition, memory, orientation, perception, thus produces the unhealthy psychology such as anxiety, depression.Along with the continuous progress of medical science and technology, Geriatric Patients also increases year by year, and gerontal patient is starkly lower than young patient to the tolerance of operation and Psychological Endurance, thus the probability that postoperative acute mental disorder occurs also rises.Postoperative acute mental disorder can cause length of patient stay to extend to be increased with medical expense, also makes the accident of postoperative infection, cardiovascular and cerebrovascular vessel increase.
Summary of the invention
The object of this invention is to provide a kind of medicament for the treatment of old postoperative acute mental disorder.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of old postoperative acute mental disorder, it is made up of the material of following weight proportioning: Cortex Alstoniae scholaris 7 parts, Paraboea dictyoneura (Hance) B. L (Burtt) grass 3 parts, Ophicalcitum 4 parts, Rhizoma Fagopyri Dibotryis 4 parts, Fructus Akebiae 7 parts, Semen Euryales 6 parts, Exocarpium Citri Grandis 9 parts, Flos Celosiae Cristatae 3 parts, Stalactitum 3 parts, Folium Polygoni Tinctorii 3 parts, Semen Cuscutae 4 parts, Semen Torreyae 8 parts, Fructus Litchi 6 parts, burden 72 parts, the Cortex Eucommiae 7 parts, Exocarpium Benincasae 3 parts, RADIX PEUCEDANI 9 parts, Caulis Polygoni Multiflori 4 parts, Semen Abutili 7 parts, Arillus Longan 4 parts, Semen Lepidii (Semen Descurainiae) 4 parts, Semen Glycine Germinatum 6 parts, Lapis Chloriti 5 parts, Rhizoma valerianae latifoliae 7 parts, Herba Saxifragae 8 parts, Spina Gleditsiae 4 parts, leaf of Turpinia pomifera (Roxb) D O. 7 parts, Chinese honey locust (fruit) 7 parts, Herba Glechomae 5 parts, Pine Nodular Branch 5 parts, Herba Adonidis 3 parts, Flos Impatientis 9 parts, Caulis Bambusae In Taenia 5 parts, Herba asparagi gobici 3 parts, Folium Et Cacumen Murrayae 5 parts, Rhizoma Saururi (Herba Saururi) 5 parts, Semen Canavaliae 9 parts, Ilex purpurea Hassk.[I.chinensis Sims 3 parts, Herba veronicastri villosuli 6 parts, Caulis Trachelospermi 4 parts, Concha Haliotidis 4 parts, Herba Lysionoti Pauciflori 5 parts, Radix Ampelopsis 4 parts, Radix Scrophulariae 6 parts, Folium Microcoris paniculatae 3 parts, Herba Commelinae 4 parts, Fructus Piperis Longi 7 parts, Stigma Maydis 5 parts, Herba Lycopodii serrati 7 parts and Fluoritum 4 parts.
In the present invention:
Burden seven
Classification system: Radix et Rhizoma Dysosmae Difformis, Dysosma difformis (Hemsl.et Wils.) T.H.WangPodophyllum difformis Hemsl.et Wils.
Gui Jing: lung; Liver Channel
Effect is classified: heat and toxic materials clearing away medicine; Dissipating phlegm and resolving masses medicine; Stasis-dispelling and pain-killing medicine
Nature and flavor: bitter in the mouth; Pungent; Cool in nature; Poisonous
Medical material Ji Yuan: be the root welding technology of Berberidaceae vegetation water Radix et Rhizoma Dysosmatis.
Cortex Alstoniae scholaris (" Luchuan book on Chinese herbal medicine ")
The bark that [source] is apocynaceae plant common alstonia or leaf.
[nature and flavor] " Luchuan book on Chinese herbal medicine ": cold in nature, micro-hardship.
Paraboea dictyoneura (Hance) B. L (Burtt) grass
[source] medical material Ji Yuan: be the herb of Oxalidaceae plant branching Biophytum nanum H. Chuang sp. Nov. Ined.-B. Sensitivum auct. Non (L.) DC..
Latin plant animal mineral name: Biophytum esquirolii levl.
[original shape state] Herba Biophyti esquirolii perennial herb.Stem height 5-15cm, normal branch, base portion lignifying.Even number winglike compound leaf, consor stem top, long 5-10cm, raw elongated pubescence dredged by rachis and lobule two mask; Lobule 8-12 couple, rarely reaches 16 right, and Long Circle or the shape of falling ovum Long Circle, slightly deflection, lobule is increased to top gradually by base portion, and top lobule is about 1cm, wide about 5mm, tool Irritability, when touching, closes like bashfully blade of grass sample.Inflorescence is several, and top is raw, the total bennet of tool, and Hua Dansheng or several are arranged in umbel on total bennet; Calyx 5, lanceolar; Petal 5, comparatively sepal is long, yellow; Stamen 10,2 take turns, and filigree is separated, and ovary is subsphaeroidal, Room 5.Capsule is oval, is shorter than persistent calyx sheet; Many, seed, surperficial tool tubercle body, tool aril.The florescence 5-10 month, the fruit phase 6-11 month.
[habitats distribution] ecological environment: be born in sparse woods or shrubbery.
[nature and flavor] are sweet, puckery; Be slightly cold.
Herba asparagi gobici [extracts] " national Chinese herbal medicine compilation "
[source] Liliaceae Asparagus plant Gobi desert Radix Asparagi Asparagus gobicus N.Iran.ex Grub., is used as medicine with whole herb with root.Autumn adopts, and dries.
[meridian distribution of property and flavor] is pungent, flat.
More preferably, medicament of the present invention is tablet, dispersible tablet, decoction or liniment.
The medicament of the old postoperative acute mental disorder for the treatment of of the present invention all adopts natural drug to make, and clear curative effect can treat old postoperative acute mental disorder effectively, therefore very suitablely promotes clinically.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
The preparation of embodiment 1 decoction
Get Cortex Alstoniae scholaris 7 grams, Paraboea dictyoneura (Hance) B. L (Burtt) grass 3 grams, Ophicalcitum 4 grams, Rhizoma Fagopyri Dibotryis 4 grams, Fructus Akebiae 7 grams, Semen Euryales 6 grams, Exocarpium Citri Grandis 9 grams, Flos Celosiae Cristatae 3 grams, Stalactitum 3 grams, Folium Polygoni Tinctorii 3 grams, Semen Cuscutae 4 grams, Semen Torreyae 8 grams, Fructus Litchi 6 grams, burden 72 grams, the Cortex Eucommiae 7 grams, Exocarpium Benincasae 3 grams, RADIX PEUCEDANI 9 grams, Caulis Polygoni Multiflori 4 grams, Semen Abutili 7 grams, Arillus Longan 4 grams, Semen Lepidii (Semen Descurainiae) 4 grams, Semen Glycine Germinatum 6 grams, Lapis Chloriti 5 grams, Rhizoma valerianae latifoliae 7 grams, Herba Saxifragae 8 grams, Spina Gleditsiae 4 grams, leaf of Turpinia pomifera (Roxb) D O. 7 grams, Chinese honey locust (fruit) 7 grams, Herba Glechomae 5 grams, Pine Nodular Branch 5 grams, Herba Adonidis 3 grams, Flos Impatientis 9 grams, Caulis Bambusae In Taenia 5 grams, Herba asparagi gobici 3 grams, Folium Et Cacumen Murrayae 5 grams, Rhizoma Saururi (Herba Saururi) 5 grams, Semen Canavaliae 9 grams, Ilex purpurea Hassk.[I.chinensis Sims 3 grams, Herba veronicastri villosuli 6 grams, Caulis Trachelospermi 4 grams, Concha Haliotidis 4 grams, Herba Lysionoti Pauciflori 5 grams, Radix Ampelopsis 4 grams, Radix Scrophulariae 6 grams, Folium Microcoris paniculatae 3 grams, Herba Commelinae 4 grams, Fructus Piperis Longi 7 grams, Stigma Maydis 5 grams, Herba Lycopodii serrati 7 grams and Fluoritum 4 grams, add 9000 ml waters, at 1 normal atmosphere, heated at reflux 5 hours, is cooled to room temperature.Filter, filtrate is decoction of the present invention.
Experimental example
Select hospital department of general surgery postoperative patient 120 example, be male more than 60 years old gerontal patient, average (62.1 ± 1.23) year; Be above educational background of graduating from primary school, can with nursing staff's proper communication; The such as mental disorder in various degree such as anxiety, disorientation, depression is all produced in postoperative 4-5d; All deny previously suffering from the organic medical history of spiritual pathogenesis brain.120 routine patients all give remedy measures.
When returning to ward after operation in patients, patient on sick bed, is avoided vibrations, prevents conduit from coming off, properly fix, ensure aseptic by nursing staff; Settle suitable position, go pillow flat sleeping, amesiality, so that discharge throat portion secretion or oral cavity vomitus, in order to avoid because having attracted to suffocate or aspiration pneumonitis by mistake.Monitoring of blood pressure, breathing, pulse record immediately, then every 15min monitors 1 time, changes 1h into and monitor 1 time steadily.Nursing staff and anesthetist and surgical doctor carefully complete transition, arrange and perform doctor's advice.Whether unobstructedly observing patient venous transfusion passage, whether suitable, ensure the unobstructed of each drainage system, and observe drain amount, color, matter if dripping speed, thus judge whether patient exists In vivo infection, hemorrhage etc.Promote wound healing, patient incision's situation is observed in postoperative timing, and early postoperation emphasis notices that dressing is with or without sepage, oozing of blood, attention local hemorrhage situation; Later stage primary part observation otch and around with or without infection symptoms such as red, swollen, hot, pains; And note protection otch surrounding skin cleannes.
The decoction using embodiment 1 to prepare is treated, one day twice, and each serving with 90 milliliters, treatment 7 days is a course for the treatment of continuously.
Evaluation index
Zung self rating depressive scale (SDS) and Zung Analysisof Self-rating Anxiety Scale (SAS) is adopted to assess the mental status before and after patient care respectively.
Statistical procedures
Adopt SPSS16.0 statistical software.The measurement data of normal distribution with
represent, compare between group and check with t.P < 0.05 represents that difference has statistical significance.
Result
| ? | Before treatment | After treatment |
| SAS | 57.51±2.14 | 33.25±2.26 * |
| SDS | 58.73±2.28 | 38.62±2.61 * |
Note: compare with before treatment, * P < 0.05
Claims (1)
1. treat a medicament for old postoperative acute mental disorder, it is characterized in that, it is made up by following method of material: get Cortex Alstoniae scholaris 7 grams, Paraboea dictyoneura (Hance) B. L (Burtt) grass 3 grams, Ophicalcitum 4 grams, Rhizoma Fagopyri Dibotryis 4 grams, Fructus Akebiae 7 grams, Semen Euryales 6 grams, Exocarpium Citri Grandis 9 grams, Flos Celosiae Cristatae 3 grams, Stalactitum 3 grams, Folium Polygoni Tinctorii 3 grams, Semen Cuscutae 4 grams, Semen Torreyae 8 grams, Fructus Litchi 6 grams, burden 72 grams, the Cortex Eucommiae 7 grams, Exocarpium Benincasae 3 grams, RADIX PEUCEDANI 9 grams, Caulis Polygoni Multiflori 4 grams, Semen Abutili 7 grams, Arillus Longan 4 grams, Semen Lepidii (Semen Descurainiae) 4 grams, Semen Glycine Germinatum 6 grams, Lapis Chloriti 5 grams, Rhizoma valerianae latifoliae 7 grams, Herba Saxifragae 8 grams, Spina Gleditsiae 4 grams, leaf of Turpinia pomifera (Roxb) D O. 7 grams, Chinese honey locust (fruit) 7 grams, Herba Glechomae 5 grams, Pine Nodular Branch 5 grams, Herba Adonidis 3 grams, Flos Impatientis 9 grams, Caulis Bambusae In Taenia 5 grams, Herba asparagi gobici 3 grams, Folium Et Cacumen Murrayae 5 grams, Rhizoma Saururi (Herba Saururi) 5 grams, Semen Canavaliae 9 grams, Ilex purpurea Hassk.[I.chinensis Sims 3 grams, Herba veronicastri villosuli 6 grams, Caulis Trachelospermi 4 grams, Concha Haliotidis 4 grams, Herba Lysionoti Pauciflori 5 grams, Radix Ampelopsis 4 grams, Radix Scrophulariae 6 grams, Folium Microcoris paniculatae 3 grams, Herba Commelinae 4 grams, Fructus Piperis Longi 7 grams, Stigma Maydis 5 grams, Herba Lycopodii serrati 7 grams and Fluoritum 4 grams, add 9000 ml waters, at 1 normal atmosphere, heated at reflux 5 hours, is cooled to room temperature, and filter, filtrate is decoction.
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| CN201310433148.XA CN103463495B (en) | 2013-09-23 | 2013-09-23 | Drug for treating senile postoperative acute mental disorders |
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| CN103463495B true CN103463495B (en) | 2015-01-14 |
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2013
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