CN105362570A - Medicine composition for treating contrast agent extravasation - Google Patents

Medicine composition for treating contrast agent extravasation Download PDF

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CN105362570A
CN105362570A CN201510948857.0A CN201510948857A CN105362570A CN 105362570 A CN105362570 A CN 105362570A CN 201510948857 A CN201510948857 A CN 201510948857A CN 105362570 A CN105362570 A CN 105362570A
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herba
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wall
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刘芳
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Jinan Xinshidai Medicine Science and Technology Co Ltd
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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a medicine composition for treating contrast agent extravasation. The medicine composition is prepared from, by weight, 4-6 parts of Chinese fan palm seeds, 4-6 parts of fewflower lysionotus herbs, 4-6 parts of pimpinella candolleana, 4-6 parts of pentasacme championii benth., 4-6 parts of arisaema sikokianum Franch., 4-6 parts of nude pronephrium rhizomes, 4-6 parts of all-grass of winkled marshweed, 4-6 parts of roots of perny germander, 4-6 parts of rhamnus aurea and 4-6 parts of leaves of Lance coreopsis. All the herbs are used in combination to achieve the effects of clearing away heat and toxic materials, promoting blood circulation to remove meridian obstruction, removing blood stasis and eliminating stagnation and relieving swelling and pain. The medicine composition has the advantage of being high in cure rate when applied to treatment of contrast agent extravasation.

Description

A kind of pharmaceutical composition for the treatment of extravasation of contrast media
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of extravasation of contrast media.
Background technology
In recent years, universal along with automatic high pressure injector and dynamic concentration injection technique, the incidence rate of extravasation of contrast media was in obviously increasing trend.Due to the characteristic of its contrast agent high concentration, high viscosity, hyperosmosis, seepage can cause rapidly injection site regional organization liquid to gather in a large number, there is hypertonicity swelling, twinge, and cause skin histology ulcer and necrosis, even cause the generation of osteofascial compartment syndrome, bring huge infringement to patient.The conventional magnesium sulfate diluent external application of tradition, though can play certain therapeutic effect, the alleviation of pain symptom, the absorption of edema are undesirable, and need remain that the area that exosmoses is moistening.Continuous replacing gauze, patient often adheres to disappearing completely less than swelling, thus extends healing time.
Summary of the invention
Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of pharmaceutical composition for the treatment of extravasation of contrast media.
The present invention is achieved through the following technical solutions:
Treat a pharmaceutical composition for extravasation of contrast media, be made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.
Preferably, the pharmaceutical composition of above-mentioned treatment extravasation of contrast media, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.
Preferred, the pharmaceutical composition of above-mentioned treatment extravasation of contrast media, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.
The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.
The indication of medicine of the present invention: be used for the treatment of extravasation of contrast media.
The method of preparation and use of medicine of the present invention: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.
The standard of fine powder is on the books in Chinese Pharmacopoeia 2010 editions 1 annex.
The taboo item of medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.
In medicine of the present invention,
Chinese fanpalm seed another name seed of Livistona chinensis R.Br. is babassu Semen livistonae chinensis Livistonachinensis(Jacq.) seed of R.Br..Sweet in the mouth; Bitter; Property is put down.Function blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.
The black black bone of Herba Lysionoti Pauciflori another name, Radix Loxostigmatis griffithii, Lysionotus pauciflorus Maxim., little Herba Lycopi, Herba Lysionoti carnosae, rock tea, Herba Ophiorrhizae japonicae, rock orchid, Ba Yancao, the red grass of lung, Semen Benincasae grass, Parmelia saxatilis Ach., puerperal tea, Eupatorium formosanum Hayata., stone Radix Notoginseng, Shi Hu, Cicerbita azurea (Ledeb.) Beavuerd, Radix Loxostigmatis griffithii, stone Fructus Myricae rubrae, rock head Radix Notoginseng, rock strip, bamboo do not sting, member orchid, pattern rake.For the herb of Gesneriaceae Herba Lysionoti Pauciflori LysionotuspauciflorusMaxim..Bitter in the mouth; Pungent; Property is put down.Function wind dehumidifies; Preventing phlegm from forming and stopping coughing; Blood stasis dispelling stimulates the menstrual flow.Main air pain of dampness syndrome; Cough with asthma abundant expectoration; Menoxenia; Dysmenorrhea; Traumatic injury.
That Radix Pimpinellae Candolleanae another name Rhizoma valerianae latifoliae, mountain Radix Angelicae Sinensis, Horse hoof Radix Saposhnikoviae, JIUYUE Pemisetum flaccidum Griseb, all over the body string, tripodia Cicadae, Pemisetum flaccidum Griseb, Yangshan are smelly, Rhizoma typhonii divaricati, clearly Radix Angelicae Sinensis, sheep are had a strong smell is smelly, Herba Calthae, Fructus Piperis, lamb have a strong smell, Radix Pimpinellae Candolleanae, nine Ns dry, sheep mountain is smelly, Great Cold medicine, grass of cooling down, rabbit ear Radix Saposhnikoviae, little hero, little Flos Chrysanthemi, be root or the herb of samphire Folium Pruni Pimpinella anisum Linn. PimpinellacandolleanaWighy day Arn.Acrid in the mouth; Micro-hardship; Warm in nature.Return lung; Spleen; Stomach; Liver Channel.Function warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling.The cold pain of main gastral cavity abdomen; Dyspepsia; Dysentery; Flu; Cough; Infantile convulsion; Leucorrhea; Hernia; The testis swelling and hanging down of either of the testes; Scrofula; Treating swelling and pain by traumatic injury; Carbuncle sore tumefacting virus; Venom.
Radix Pentasacmi championii another name five, southern stone Herba seu Radix Metaplexis hemsleyanae, false fourth Diao Zhu, Herba Pteridis Multifidae, full grass, Radix Homonoiae Ripariae, be the herb of dicotyledon medicine asclepiadaceae stone Herba seu Radix Metaplexis hemsleyanae PendasacmechampioniiBenth..Bitter in the mouth; Micro-pungent; Cool in nature.Return liver; Gallbladder meridian.Function is fallen apart wind heat clearing away; Removing toxic substances and promoting subsidence of swelling.Main anemopyretic cold; Cough; Pharyngalgia; Conjunctival congestion; Hepatitis; Venom.
Rhizoma Arisaemati another name LUBIANHUANG, Serpentis Semen Maydis, old Serpentis Semen Maydis are the tuber of aroid Rhizoma Arisaemati ArisaemasikokianumFuanch. day or full edge Rhizoma Arisaemati Sav.var.s day tatum (Makino) Hand.-Mazz [A.sazensoovar.serratumMakino] 2.ArisaemasikokianumFranch. day Sav..Bitter in the mouth, pungent; Warm in nature.Return lung; Liver Channel.Function drying dampness to eliminate phlegm; Relieving spasm by subduing liver-wind; Reducing swelling and alleviating pain.Main productive cough due to phlegm-damp; Dizziness due to wind-phlegm; Epilepsy; Apoplexy; Facial hemiparalysis; Tetanus; Carbuncle; Venom.
Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching calls large plumage crescent Herba pteridii latiusculi, Coniogramme japonica (Thunb.) Diels, derives from fern Athyriaceae Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching Abacopterismultilineata(Wall.) Ching, is used as medicine with root stock.Bitter in the mouth, cold in nature.Function dredge the meridian passage, dampness removing of regulating the flow of vital energy.Cure mainly impairment caused by overstrain, peratodynia, dysentery, menoxenia.
Herba Limnophilae rugosae another name Tian Gencao, water mint, Rhizoma begoniae pedatifidae, water Herba Schizonepetae, ripples perfume, wrinkle leaf Herba Limnophilae sessiliflorae are the herb of goatweed Limnophila rugosa NitellaexpansaAllen, Limnophilarugosa (Roth) Merr..Acrid in the mouth; Sweet; Warm in nature.Return lung; Spleen; Stomach warp.Function invigorating spleen to remove dampness; Activating QI to eliminate phlegm.Main edema; Stomachache; Distension and fullness of the chest and abdomen; Cough; Children's's infantile dyspepsia; Furuncle.
Radix Teucrii Pernyi another name Mount Lushan spice, derives from Labiatae and spends Phryganeajaponica Ml. TeucriumpernyiFranch. in vain, be used as medicine with root.Taste is micro-sweet, warm in nature.Function invigorating spleen to remove dampness, removing toxic substances.Cure mainly dysentery.
Herba lespedezae pilosae another name Herba cassiae torae, derives from pulse family Lespedeza plant Herba lespedezae pilosae Lespedezapilosa(Thunb.) Sieb. day Zucc., is used as medicine with root and Herb.Bitter in the mouth, pungent, property is put down.Function heat clearing away eliminating stagnation, promoting blood circulation and stopping pain, line water detumescence.For lymphoid tuberculosis, cold abscess, deficiency-heat is not moved back, edema, waist hamstring osteodynia; Mastitis are controlled in external.
Folium Coreopsis lanceolatae another name Coreopsis lanceolata, sword-like leave coreopsis, derive from Compositae Folium Coreopsis lanceolatae CoreopsislanceolataL., with all herbal medicine.Acrid in the mouth, property is put down.Function blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.Cure mainly knife injury, innominate toxic swelling.
In medicine of the present invention, Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; Herba Lysionoti Pauciflori heat clearing and damp drying, reducing swelling and alleviating pain; Radix Pimpinellae Candolleanae promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling; Radix Pentasacmi championii falls apart wind heat clearing away, removing toxic substances and promoting subsidence of swelling; Rhizoma Arisaemati drying dampness to eliminate phlegm, reducing swelling and alleviating pain; Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching dredge the meridian passage, regulating QI to expel dampness; Herba Limnophilae rugosae, Radix Teucrii Pernyi invigorating spleen to remove dampness, activating QI to eliminate phlegm; Herba lespedezae pilosae heat clearing away eliminating stagnation, promoting blood circulation and stopping pain; Folium Coreopsis lanceolatae blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.All medicines share, and play heat-clearing and toxic substances removing altogether, promoting blood circulation to remove obstruction in the collateral, blood stasis-eliminating and stagnation-dissipating, the effect of reducing swelling and alleviating pain.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Treat a pharmaceutical composition for extravasation of contrast media, each crude drug weight proportion is as follows:
Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 60g.
Method of preparation and use: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.
Embodiment 2
Treat a pharmaceutical composition for extravasation of contrast media, each crude drug weight proportion is as follows:
Chinese fanpalm seed 50g, Herba Lysionoti Pauciflori 70g, Radix Pimpinellae Candolleanae 50g, Radix Pentasacmi championii 70g, Rhizoma Arisaemati 50g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 70g, Herba Limnophilae rugosae 50g, Radix Teucrii Pernyi 70g, Herba lespedezae pilosae 50g, Folium Coreopsis lanceolatae 70g.
Method of preparation and use is with embodiment 1.
Embodiment 3
Treat a pharmaceutical composition for extravasation of contrast media, each crude drug weight proportion is as follows:
Chinese fanpalm seed 70g, Herba Lysionoti Pauciflori 50g, Radix Pimpinellae Candolleanae 70g, Radix Pentasacmi championii 50g, Rhizoma Arisaemati 70g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 50g, Herba Limnophilae rugosae 70g, Radix Teucrii Pernyi 50g, Herba lespedezae pilosae 70g, Folium Coreopsis lanceolatae 50g.
Method of preparation and use is with embodiment 1.
Embodiment 4
Treat a pharmaceutical composition for extravasation of contrast media, each crude drug weight proportion is as follows:
Chinese fanpalm seed 40g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 40g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 40g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 40g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 40g, Folium Coreopsis lanceolatae 60g.
Method of preparation and use is with embodiment 1.
Embodiment 5
Treat a pharmaceutical composition for extravasation of contrast media, each crude drug weight proportion is as follows:
Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 40g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 40g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 40g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 40g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 40g.
Method of preparation and use is with embodiment 1.
Carried out clinical pharrnacokinetics test to medicine of the present invention, Details as Follows:
1 data and method
1.1 physical data use the happy double spiral CT machine of Siemens, adapted An Ke company ASA-200e automatic high pressure injector, the iohexol inj of contrast agent nonionic, dosage 1.5 ~ 2mLkg -1, speed 2 ~ 4mLS -1.By 80 of contrast agent drug extravasation routine patients, adopt SPSS16.0 software that patient is divided into observation group and matched group.Observation group 40 example: wherein man 26 example, female 14 example, 53.5 years old mean age; Average drug exosmoses area 7.5 ± 1.3cm 2.Matched group 40 example: man 22 example, female 18 example, 51.3 years old mean age, average drug exosmoses area 7.32 ± 1.35cm 2.Through comparability inspection, sex composition, the age of two groups of patients, the equal not statistically significant of Area comparison difference of exosmosing (P<0.05).
1.2 methods get the pharmaceutical composition fine powder of the embodiment of the present invention 1 according to the extent of disease that exosmoses, furnishing pasty state is fully mixed with tea, with aseptic cotton carrier, the pharmaceutical composition fine powder of the embodiment of the present invention 1 mixed up is applied to position of exosmosing equably, to exceed the extent of disease 1 ~ 2cm that exosmoses, thick about 1 ~ 2mm is advisable, and 2 times on the 1st, covers with sterile gauze, blend compounds cloth is fixed, to prevent drug volatilization and to pollute clothing.Matched group is got sterile gauze and is dipped in 50% Adlerika soak, soak area and the same observation group of number of times.All forbid partial hot compressing, and advise lifting affected limb for two groups.
1.3 observation item patient pain symptoms alleviate the time, subcutaneous swelling regression time, limb activity degree and skin tension recovery situation.
1.4 curative effect determinate standards are cured: local causalgia disappears, and swelling disappears, and skin tension recovers normal, and limb activity freely; Effective: local pain symptom obviously alleviates, skin tension reduces, and swelling area reduces or disappears, and limb activity recovers gradually; Invalid: local pain is without alleviation or phlebitis occurs, tissue necrosis, ulcer.
Between 1.5 statistical method groups, measurement data compares employing t inspection.
2 results
2.1 liang of group differences exosmose area patient curative effect in table 1.
Observation group's cure rate is 85.0%, and total effective rate is 100%; And matched group cure rate is 65.0%, total effective rate is 100%.Compared with matched group, there were significant differences for both cure rates (P<0.05).

Claims (3)

1. treat a pharmaceutical composition for extravasation of contrast media, be made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.
2. the pharmaceutical composition for the treatment of extravasation of contrast media according to claim 2, is characterized in that, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.
3. the pharmaceutical composition for the treatment of extravasation of contrast media according to claim 2, is characterized in that, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.
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CN106138522A (en) * 2016-07-22 2016-11-23 张文军 A kind of liniment treating CT enhanced ct scans extravasation of contrast media and preparation method

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JP2007070336A (en) * 2005-08-12 2007-03-22 Takehito Kono Hair growing substance
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CN103463495A (en) * 2013-09-23 2013-12-25 陈军 Drug for treating senile postoperative acute mental disorders

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JP2007070336A (en) * 2005-08-12 2007-03-22 Takehito Kono Hair growing substance
CN103463496A (en) * 2013-09-23 2013-12-25 祝爱莲 Drug for treating ankylosing spondylitis
CN103463495A (en) * 2013-09-23 2013-12-25 陈军 Drug for treating senile postoperative acute mental disorders

Cited By (1)

* Cited by examiner, † Cited by third party
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CN106138522A (en) * 2016-07-22 2016-11-23 张文军 A kind of liniment treating CT enhanced ct scans extravasation of contrast media and preparation method

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