CN105497373A - Medicine for preventing closed-fracture early-stage tension vesicles from being generated and developed - Google Patents

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medicine for preventing closed-fracture early-stage tension vesicles from being generated and developed. The medicine comprises, by weight, 4-6 parts of Chinese fan palm seeds, 4-6 parts of fewflower lysionotus herbs, 4-6 parts of roots of candolle pimpinella, 4-6 parts of roots of champion pentasacme, 4-6 parts of tubers of serrate sikoku jackinthepulpit, 4-6 parts of nude pronephrium rhizomes, 4-6 parts of all-grass of winkled marshweed, 4-6 parts of roots of perny germander, 4-6 parts of herbs of pilose bushclover and 4-6 parts of leaves of lance coreopsis. All the medicinal materials are combined to jointly achieve the effects of clearing heat, removing toxicity, activating blood, relieving swelling, regulating qi, eliminating stagnation, dispersing blood stasis and relieving pain, the medicine is used for preventing closed-fracture early-stage tension vesicles from being generated and developed, and the total effective rate is up to 97.7%.

Description

A kind of medicine prevented and treated the early stage Tension Vesicle of closed fracture and formed and develop

Technical field

The invention belongs to medical art, be specifically related to a kind of medicine prevented and treated the early stage Tension Vesicle of closed fracture and formed and develop.

Background technology

Local soft tissue major injury after fracture, tunica intima is impaired, then thromboembolism, lymphostasis, organize the penetrating raw increase of blood capillary, liquid oozes out and increases, and adds that interior unboiled water weakness between epidermis, corium that liquefaction and necrosis produces gathers formation Tension Vesicle.The Tension Vesicle that fracture acute stage occurs not only increases the chance of infection, brings misery, but also can cause serious complication, cause disease treatment complicated to patient.Therefore prevention closed flight of steps leading to a palace hall fracture backward pull blister is formed, and has important clinical meaning more afterwards to what fracture.Have not yet to see the medicine report prevented and treated the early stage Tension Vesicle of closed fracture and formed and develop.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of medicine prevented and treated the early stage Tension Vesicle of closed fracture and formed and develop.

The present invention is achieved through the following technical solutions:

Prevent and treat the medicine that the early stage Tension Vesicle of closed fracture is formed and develops, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.

Preferably, the above-mentioned medicine preventing and treating the early stage Tension Vesicle formation of closed fracture and development, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.

Preferred, the above-mentioned medicine preventing and treating the early stage Tension Vesicle formation of closed fracture and development, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of medicine of the present invention: formed and development for preventing and treating the early stage Tension Vesicle of closed fracture.

The method of preparation and use of medicine of the present invention: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with tea, vinegar, Mel or Ovum Gallus domesticus album etc.

The standard of fine powder is on the books in Chinese Pharmacopoeia 2010 editions 1 annex.

The taboo item of medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In medicine of the present invention,

Chinese fanpalm seed another name seed of Livistona chinensis R.Br. is babassu Semen livistonae chinensis Livistonachinensis(Jacq.) seed of R.Br..Sweet in the mouth; Bitter; Property is put down.Function blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.

The black black bone of Herba Lysionoti Pauciflori another name, Radix Loxostigmatis griffithii, Lysionotus pauciflorus Maxim., little Herba Lycopi, Herba Lysionoti carnosae, rock tea, Herba Ophiorrhizae japonicae, rock orchid, Ba Yancao, the red grass of lung, Semen Benincasae grass, Parmelia saxatilis Ach., puerperal tea, Eupatorium formosanum Hayata., stone Radix Notoginseng, Shi Hu, Cicerbita azurea (Ledeb.) Beavuerd, Radix Loxostigmatis griffithii, stone Fructus Myricae rubrae, rock head Radix Notoginseng, rock strip, bamboo do not sting, member orchid, pattern rake.For the herb of Gesneriaceae Herba Lysionoti Pauciflori LysionotuspauciflorusMaxim..Bitter in the mouth; Pungent; Property is put down.Function wind dehumidifies; Preventing phlegm from forming and stopping coughing; Blood stasis dispelling stimulates the menstrual flow.Main air pain of dampness syndrome; Cough with asthma abundant expectoration; Menoxenia; Dysmenorrhea; Traumatic injury.

That Radix Pimpinellae Candolleanae another name Rhizoma valerianae latifoliae, mountain Radix Angelicae Sinensis, Horse hoof Radix Saposhnikoviae, JIUYUE Pemisetum flaccidum Griseb, all over the body string, tripodia Cicadae, Pemisetum flaccidum Griseb, Yangshan are smelly, Rhizoma typhonii divaricati, clearly Radix Angelicae Sinensis, sheep are had a strong smell is smelly, Herba Calthae, Fructus Piperis, lamb have a strong smell, Radix Pimpinellae Candolleanae, nine Ns dry, sheep mountain is smelly, Great Cold medicine, grass of cooling down, rabbit ear Radix Saposhnikoviae, little hero, little Flos Chrysanthemi, be root or the herb of samphire Folium Pruni Pimpinella anisum Linn. PimpinellacandolleanaWighy day Arn.Acrid in the mouth; Micro-hardship; Warm in nature.Return lung; Spleen; Stomach; Liver Channel.Function warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling.The cold pain of main gastral cavity abdomen; Dyspepsia; Dysentery; Flu; Cough; Infantile convulsion; Leucorrhea; Hernia; The testis swelling and hanging down of either of the testes; Scrofula; Treating swelling and pain by traumatic injury; Carbuncle sore tumefacting virus; Venom.

Radix Pentasacmi championii another name five, southern stone Herba seu Radix Metaplexis hemsleyanae, false fourth Diao Zhu, Herba Pteridis Multifidae, full grass, Radix Homonoiae Ripariae, be the herb of dicotyledon medicine asclepiadaceae stone Herba seu Radix Metaplexis hemsleyanae PendasacmechampioniiBenth..Bitter in the mouth; Micro-pungent; Cool in nature.Return liver; Gallbladder meridian.Function is fallen apart wind heat clearing away; Removing toxic substances and promoting subsidence of swelling.Main anemopyretic cold; Cough; Pharyngalgia; Conjunctival congestion; Hepatitis; Venom.

Rhizoma Arisaemati another name LUBIANHUANG, Serpentis Semen Maydis, old Serpentis Semen Maydis are the tuber of aroid Rhizoma Arisaemati ArisaemasikokianumFuanch. day or full edge Rhizoma Arisaemati Sav.var.s day tatum (Makino) Hand.-Mazz [A.sazensoovar.serratumMakino] 2.ArisaemasikokianumFranch. day Sav..Bitter in the mouth, pungent; Warm in nature.Return lung; Liver Channel.Function drying dampness to eliminate phlegm; Relieving spasm by subduing liver-wind; Reducing swelling and alleviating pain.Main productive cough due to phlegm-damp; Dizziness due to wind-phlegm; Epilepsy; Apoplexy; Facial hemiparalysis; Tetanus; Carbuncle; Venom.

Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching calls large plumage crescent Herba pteridii latiusculi, Coniogramme japonica (Thunb.) Diels, derives from fern Athyriaceae Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching Abacopterismultilineata(Wall.) Ching, is used as medicine with root stock.Bitter in the mouth, cold in nature.Function dredge the meridian passage, dampness removing of regulating the flow of vital energy.Cure mainly impairment caused by overstrain, peratodynia, dysentery, menoxenia.

Herba Limnophilae rugosae another name Tian Gencao, water mint, Rhizoma begoniae pedatifidae, water Herba Schizonepetae, ripples perfume, wrinkle leaf Herba Limnophilae sessiliflorae are the herb of goatweed Limnophila rugosa NitellaexpansaAllen, Limnophilarugosa (Roth) Merr..Acrid in the mouth; Sweet; Warm in nature.Return lung; Spleen; Stomach warp.Function invigorating spleen to remove dampness; Activating QI to eliminate phlegm.Main edema; Stomachache; Distension and fullness of the chest and abdomen; Cough; Children's's infantile dyspepsia; Furuncle.

Radix Teucrii Pernyi another name Mount Lushan spice, derives from Labiatae and spends Phryganeajaponica Ml. TeucriumpernyiFranch. in vain, be used as medicine with root.Taste is micro-sweet, warm in nature.Function invigorating spleen to remove dampness, removing toxic substances.Cure mainly dysentery.

Herba lespedezae pilosae another name Herba cassiae torae, derives from pulse family Lespedeza plant Herba lespedezae pilosae Lespedezapilosa(Thunb.) Sieb. day Zucc., is used as medicine with root and Herb.Bitter in the mouth, pungent, property is put down.Function heat clearing away eliminating stagnation, promoting blood circulation and stopping pain, line water detumescence.For lymphoid tuberculosis, cold abscess, deficiency-heat is not moved back, edema, waist hamstring osteodynia; Mastitis are controlled in external.

Folium Coreopsis lanceolatae another name Coreopsis lanceolata, sword-like leave coreopsis, derive from Compositae Folium Coreopsis lanceolatae CoreopsislanceolataL., with all herbal medicine.Acrid in the mouth, property is put down.Function blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.Cure mainly knife injury, innominate toxic swelling.

In medicine of the present invention, Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; Herba Lysionoti Pauciflori heat clearing and damp drying, reducing swelling and alleviating pain; Radix Pimpinellae Candolleanae promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling; Radix Pentasacmi championii falls apart wind heat clearing away, removing toxic substances and promoting subsidence of swelling; Rhizoma Arisaemati drying dampness to eliminate phlegm, reducing swelling and alleviating pain; Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching dredge the meridian passage, regulating QI to expel dampness; Herba Limnophilae rugosae, Radix Teucrii Pernyi invigorating spleen to remove dampness, activating QI to eliminate phlegm; Herba lespedezae pilosae heat clearing away eliminating stagnation, promoting blood circulation and stopping pain; Folium Coreopsis lanceolatae blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.All medicines share, and play heat-clearing and toxic substances removing altogether, promoting blood circulation and detumescence, eliminating stagnation of regulating the flow of vital energy, the effect of blood-activating analgetic.

Medicine ingredient of the present invention all belongs to natural plants, non-stimulated to skin, in clinical treatment, does not occur untoward reaction; And mastic is soft, breathability is strong, feels comfortable, does not affect limb motion, improve the compliance of patient treatment; This unguentum is permanent for action time, changes number of times few, easy to use.Shorten the nursing time, improve work efficiency.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Prevent and treat the medicine that the early stage Tension Vesicle of closed fracture is formed and develops, each crude drug weight proportion is as follows:

Chinese fanpalm seed 6g, Herba Lysionoti Pauciflori 6g, Radix Pimpinellae Candolleanae 6g, Radix Pentasacmi championii 6g, Rhizoma Arisaemati 6g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6g, Herba Limnophilae rugosae 6g, Radix Teucrii Pernyi 6g, Herba lespedezae pilosae 6g, Folium Coreopsis lanceolatae 6g.

Method of preparation and use: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with tea, vinegar or Ovum Gallus domesticus album etc.

Embodiment 2

Prevent and treat the medicine that the early stage Tension Vesicle of closed fracture is formed and develops, each crude drug weight proportion is as follows:

Chinese fanpalm seed 5g, Herba Lysionoti Pauciflori 7g, Radix Pimpinellae Candolleanae 5g, Radix Pentasacmi championii 7g, Rhizoma Arisaemati 5g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 7g, Herba Limnophilae rugosae 5g, Radix Teucrii Pernyi 7g, Herba lespedezae pilosae 5g, Folium Coreopsis lanceolatae 7g.

Method of preparation and use is with embodiment 1.

Embodiment 3

Prevent and treat the medicine that the early stage Tension Vesicle of closed fracture is formed and develops, each crude drug weight proportion is as follows:

Chinese fanpalm seed 7g, Herba Lysionoti Pauciflori 5g, Radix Pimpinellae Candolleanae 7g, Radix Pentasacmi championii 5g, Rhizoma Arisaemati 7g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5g, Herba Limnophilae rugosae 7g, Radix Teucrii Pernyi 5g, Herba lespedezae pilosae 7g, Folium Coreopsis lanceolatae 5g.

Method of preparation and use is with embodiment 1.

Embodiment 4

Prevent and treat the medicine that the early stage Tension Vesicle of closed fracture is formed and develops, each crude drug weight proportion is as follows:

Chinese fanpalm seed 4g, Herba Lysionoti Pauciflori 6g, Radix Pimpinellae Candolleanae 4g, Radix Pentasacmi championii 6g, Rhizoma Arisaemati 4g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6g, Herba Limnophilae rugosae 4g, Radix Teucrii Pernyi 6g, Herba lespedezae pilosae 4g, Folium Coreopsis lanceolatae 6g.

Method of preparation and use is with embodiment 1.

Embodiment 5

Prevent and treat the medicine that the early stage Tension Vesicle of closed fracture is formed and develops, each crude drug weight proportion is as follows:

Chinese fanpalm seed 6g, Herba Lysionoti Pauciflori 4g, Radix Pimpinellae Candolleanae 6g, Radix Pentasacmi championii 4g, Rhizoma Arisaemati 6g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4g, Herba Limnophilae rugosae 6g, Radix Teucrii Pernyi 4g, Herba lespedezae pilosae 6g, Folium Coreopsis lanceolatae 4g.

Method of preparation and use is with embodiment 1.

Carried out clinical pharrnacokinetics test to medicine of the present invention, Details as Follows:

1 object and method

The convenient sampling method of 1.1 objects chooses 171 routine patients for object of study.Wherein man 122 example, female 49 example; 12-85 years old ages, average (38.6 ± 6.5) year.Inclusion criteria: the limb trauma history that (1) is clear and definite, x line sheet display fracture.(2) be closed fracture, skin complete, hinder limb with swelling in various degree, and be one-sided limbs.(3) clients in injured rear 2 ~ 7h, all needs operative treatment.(4) swelling degree is I, II, III degree of struttuer.Exclusion standard: (1) spiritedness, internal disease person.(2) nerve, blood vessel injury person is had.(3) pathologisch Bruch such as bone tumor, bone tuberculosis patient.(4) skin injury person.The random observation group 90 that is divided into is routine, wherein I degree swelling 43 example, II degree of swelling 29 example, III degree of swelling 18 example.Fracture of upper limb 41 example (supracondylar fracture of the humerus 10 example, ulna and radius dry fracture l5 example, colles' fracture 16 example), fracture of the lower limb 49 example (femoral shaft hypomere fractures in 11 cases, Treatment of fractures of tibia-fibula shaft 23 example, ankle fracture 15 example); Matched group 81 example, wherein I degree swelling 29 example, II degree of swelling 22 example, III degree of swelling 30 example.Fracture of upper limb 37 example (supracondylar fracture of the humerus 11 example, the dry 16 cases of fractures of ulna and radius, colles' fracture 10 example), fracture of the lower limb 44 example (femoral shaft hypomere fracture 12 example, Treatment of fractures of tibia-fibula shaft 22 example, ankle fracture 10 example).Two groups of patient no significant difference P>0.05 in sex, age, limb swelling degree etc.), there is comparability.

1.2 method

1.2.1 Therapeutic Method matched group takes lifting affected limb, and is placed in functional position, uses the detumescence such as aescine, mannitol, exudation Drug therapy.Observation group is on the basis of matched group, with naturally waiting after warm water cleaning suffering limb to do, get the medicine of the appropriate embodiment of the present invention 1 according to extent of disease and Mel fully mixes in 1:2 ratio, furnishing pasty state, spread on affected part outward, avoid skin lesion place (then avoiding blister as formed blister, avoiding skin ulceration), be advisable to exceed extent of disease 1 ~ 2cm, thickness is about 1mm, and cover with sterile gauze, immobilization with adhesive tape, every 24h changes dressings once.Treatment terminates rear observation two groups of patients and is formed with or without Tension Vesicle, and record blister forms rear regression time.

1.2.2 observational technique timing every day is observed and is formed with or without Tension Vesicle.Continuous monitoring 5d, is responsible for observing to be formed with or without blister and to measure blister diameter and record by the same professional nurse practitioner.Note observing area of coverage local skin with or without the anaphylaxis such as skin rubefaction, pruritus.If any above-mentioned symptom, timely stopped treatment, observation group has 3 example generation anaphylaxiss to exit, and includes bolter in intentional analysis.

1.2.3 swelling degree evaluation is formulated with reference to symptoms of soft tissue injuries grade scale according to " new Chinese medicine guideline of clinical investigations ".I degree swelling: compared with normal skin turgor, but dermatoglyph remains, Ipsilateral and strong side with position week footpath poor≤05cm.LI degree swelling: all footpaths difference is 0.5 ~ 1cm, dermatoglyph disappears.But without blister.III degree of swelling: blister, appears in all footpath difference > 1cm.

1.2.4 clinical efficacy evaluation criteria is cured: observe established blister diameter when starting and no longer increase, heal after suction therapy; Effective: after 3 ~ 5d, no-station pole canopy blister is formed; Invalid: observe and start to form Tension Vesicle in 2d, or the blister diameter existed when observation starts to continue to increase, and is formed once again after suction.

The all data of 1.3 statistical procedures all input SPSS11.0 statistical software.Enumeration data adopts χ ²with P < 0.05, inspection, represents that difference has statistical significance.

A table 1 liang group prevention Tension Vesicle forms effectiveness comparison example

Group	Number of cases	Cure	Effectively	Invalid	Exit	Cure rate %	Total effective rate (%)
								Matched group	81	15	47	19	0	18.52	76.5
Observation group	90	28	57	2	3	32.18*	97.7*

* compared with matched group, P < 0.05.

Claims (3)

1. prevent and treat the medicine that the early stage Tension Vesicle of closed fracture is formed and develops, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.

2. the medicine prevented and treated the early stage Tension Vesicle of closed fracture and formed and develop according to claim 1, is characterized in that, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.

3. the medicine prevented and treated the early stage Tension Vesicle of closed fracture and formed and develop according to claim 3, is characterized in that, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.