CN106421009A - Paste for preventing and treating closed fracture tension vesicle and preparation method of paste - Google Patents
Paste for preventing and treating closed fracture tension vesicle and preparation method of paste Download PDFInfo
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- CN106421009A CN106421009A CN201610887539.2A CN201610887539A CN106421009A CN 106421009 A CN106421009 A CN 106421009A CN 201610887539 A CN201610887539 A CN 201610887539A CN 106421009 A CN106421009 A CN 106421009A
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- herba
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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Abstract
The invention discloses paste for preventing and treating closed fracture tension vesicle. The paste is characterized by being prepared from the following components in parts by mass: 10 to 30 parts of carbonized sanguisorba roots, 10 to 25 parts of borneol and 15 to 30 parts of sesame oil. The preparation method of the paste for preventing and treating the closed fracture tension vesicle is characterized by comprising the following steps: putting the borneol into an iron kettle, adding white spirit, performing heating stirring till the white spirit is 160 to 200 degrees for 2 hours, cooling to room temperature, then adding 10 to 25 parts of borneol and 15 to 30 parts of the sesame oil, uniformly stirring, adding a first extract, a second extract, a third extract or a fourth extract, and dripping to paste paper. The components in the paste belong to natural plants, and are non-irritant to the skin; the paste does not cause adverse reactions in clinical treatment; furthermore, the paste is soft and high in gas permeability; people feel comfortable; limb movement cannot be affected; the curing rate of a patient is increased.
Description
Technical field
The present invention relates to pharmaceutical technology field, more precisely a kind of unguentum for preventing and treating closed fracture Tension Vesicle
And preparation method thereof.
Background technology
Local soft tissue major injury after fracture, tunica intima is impaired, then thromboembolism, lymphostasis, organizes capillary
Vascular permeability life increases, and liquid oozes out and increases, and adds interior unboiled water weakness accumulation between epidermis, corium of liquefaction and necrosis generation
Form Tension Vesicle.The Tension Vesicle that fracture acute stage occurs not only increases the chance of infection, brings pain to patient,
But also serious complication can be caused, cause disease treatment to complicate.Therefore prevention closes flight of steps leading to a palace hall fracture backward pull blister shape
Become, to fractured, there is important clinical meaning more afterwards.Have not yet to see the medicine for preventing and treating closed fracture Tension Vesicle
Report.
Content of the invention
It is an object of the invention to provide a kind of unguentum for preventing and treating closed fracture Tension Vesicle and preparation method thereof, its
Disadvantages mentioned above of the prior art can be solved.
The present invention is employed the following technical solutions：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, it is characterised in that including following various of mass fraction
Component：Charred Radix Sanguisorbae 10-30 part, Borneolum Syntheticum 10-25 part, Oleum sesami 15-30 part.
Also include the following various components of mass fraction：
15 parts of Cortex Fraxini Malacophyllae Radiciss, 10 parts of Herba Monochoriae Korsakowii, Radix Lamiophlomidis Rotatae 5-8 part, Polygonum runcinatum var. sinense Hemsl. 2-3 part, Cortex Phellodendri 4-6 part, Bao Tuancao 4-6 part, stand
Muscle grass 3-5 part, Myrrha (processed) 6-8 part, Fructus Aurantii 2-4 part, Rhizoma Kaempferiae 3-4 part.
Also include the following various components of mass fraction：Cacumen Myricariae Germanicae 10-20 part, Radix Rehmanniae Preparata 2-3 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 3-7 part, Flos Citri Sarcodactyliss
2-3 part, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, Semen Strychni 2-5 part, Radix Et Rhizoma Nardostachyos 6-8 part, Folium Ricini 5-7 part and red chopsticks
15 parts of son.
Also include mass fraction various components as follows：15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, Herba indigoferae bungeanae 10
Part, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., 5 parts of Herba malachii aquatici, Rhizoma Corydalis 8-10 part, Eupolyphaga Seu Steleophaga 1-2, Herba Lycopi's 3-5 part, Cortex cercis chinensiss 6-8
Part, Herba Acalyphae 4-6 part, Rhizoma Paridis 2-4 part, Herba Centipedae 2-4 part.
Also include the following various components of mass fraction：
Mentholum 15-50 part, Cortex Eucommiae 15-30 part, Radix Angelicae Pubescentiss 15-30 part, Rhizoma Et Radix Notopterygii 15-30 part, continue disconnected 15-40 part, the Qin
Macrophylla 15-50 part, Moschus 15-40 part, Cornu Cervi Pantotrichum 15-40 part, Hippocampus 15-40 part, Scolopendra 15-30 part, Carapax Trionycis 15-50 part.
A kind of preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle, deionized water is added in reaction pot,
62-78 DEG C is heated to, adds 15 parts of Cortex Fraxini Malacophyllae Radiciss, 10 parts of Herba Monochoriae Korsakowii, Radix Lamiophlomidis Rotatae 5-8 part, Polygonum runcinatum var. sinense Hemsl. 2-3 part, Cortex Phellodendri 4-6 while stirring
Part, Bao Tuancao 4-6 part, stand muscle grass 3-5 part, Myrrha (processed) 6-8 part, Fructus Aurantii 2-4 part, Rhizoma Kaempferiae 3-4 part, mixing and stirring, continues
Decoct 3h while stirring, decocting for Chinese herbal medicine liquid is filtered to obtain, place at 10-28 DEG C and process 30 minutes, filter, obtain Chinese medicine extract
Solution, described Chinese medicine extract solution is concentrated into relative density for 1.020-1.105 at 20 DEG C, obtains the first extract.
By Cacumen Myricariae Germanicae 10-20 part, Radix Rehmanniae Preparata 2-3 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 3-7 part, Flos Citri Sarcodactyliss 2-3 part, 15 parts of HERBA VERONICAE DILATATAE, Herba Tricyrtis Pilosae 15
After part, 15 parts of Flos koelreuteriae paniculatae, Semen Strychni 2-5 part, Radix Et Rhizoma Nardostachyos 6-8 part, Folium Ricini 5-7 part and 15 parts of dryings of Herba Epilobii Angustifoii, crushed with pulverizer
Become coarser powder, compare 1 according to water quality:5～1:7 are evenly mixed in decoction in the pot with pot cover, and big fire uses boiling with soft fire 1 after boiling again
～5 hours or so, leach decocting liquid；So 2～3 times repeatedly, collecting decoction, filters, stands 15 hours, take the supernatant dense
Contracting, obtains the second extract.
15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, 10 parts of Herba indigoferae bungeanae, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., goose
5 parts of intestinal dish, Rhizoma Corydalis 8-10 part, Eupolyphaga Seu Steleophaga 1-2, Herba Lycopi's 3-5 part, Cortex cercis chinensiss 6-8 part, Herba Acalyphae 4-6 part, Rhizoma Paridis 2-
4 parts, the crushing of Herba Centipedae 2-4 part, add ethanol, heating in water bath backflow 0.5h, sucking filtration, filtering residue repetition aforesaid operations process two
Secondary, merging filtrate, impurity is filtered, is cooled to room temperature, sucking filtration, it is concentrated to give the 3rd extract.
Mentholum 15-50 part, Cortex Eucommiae 15-30 part, Radix Angelicae Pubescentiss 15-30 part, Rhizoma Et Radix Notopterygii 15-30 part, continue disconnected 15-40 part, the Qin
Macrophylla 15-50 part, Moschus 15-40 part, Cornu Cervi Pantotrichum 15-40 part, Hippocampus 15-40 part, Scolopendra 15-30 part, Carapax Trionycis 15-50 part.
Crush, 95% alcohol-pickled for 3 times, merge ethanol extract, vacuum distillation obtains sepia extractum, moisture uses water, second after dissipating successively
Ether and ethyl acetate are extracted, and ethyl acetate portion vacuum distillation is concentrated to give the 4th extract.
Borneolum Syntheticum is placed in iron still, Chinese liquor is added, heated and stirred is cooled to room temperature and then adds to 160-200 degree to 2h
Enter Borneolum Syntheticum 10-25 part and Oleum sesami 15-30 part, stir, add the first extract, the second extract, the 3rd extract or the
Four extracts are poured on plaster paper.
It is an advantage of the invention that：Medicine ingredient belongs to natural plants, non-stimulated to skin, in clinical treatment,
There is not untoward reaction；And mastic softness, breathability by force, is comfortable on, does not affect limb motion, improves patient's treatment
Compliance；This unguentum is permanent for action time, and replacing number of times is few, easy to use, shortens the nursing time.
Specific embodiment
With reference to the specific embodiment that the present invention is expanded on further：
Embodiment 1：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami.
Embodiment 2：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
15 parts of charred Radix Sanguisorbae, 20 parts of Borneolum Syntheticum, 22 parts of Oleum sesami.
Embodiment 3：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
20 parts of charred Radix Sanguisorbae, 18 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 10 parts of Herba Monochoriae Korsakowii, 6 parts of Radix Lamiophlomidis Rotatae, 2.5 parts of Polygonum runcinatum var. sinense Hemsl., 5 parts of Cortex Phellodendri,
5 parts of Bao Tuancao, stand 4 parts of muscle grass, 7 parts of Myrrha (processed), 3 parts of Fructus Aurantii, 3 parts of Rhizoma Kaempferiae.
Embodiment 4：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 20 parts of Borneolum Syntheticum, 20 parts of Oleum sesami, 15 parts of Cacumen Myricariae Germanicae, 2.5 parts of Radix Rehmanniae Preparata, 5 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Citri Sarcodactyliss 2.5
Part, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, Semen Strychni 2-5 part, 7 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Folium Ricini and 15 parts of Herba Epilobii Angustifoii.
Embodiment 5：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, Herba indigoferae bungeanae
10 parts, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., 5 parts of Herba malachii aquatici, Rhizoma Corydalis 8-10 part, Eupolyphaga Seu Steleophaga 1.5,4 parts of Herba Lycopi, Cortex cercis chinensiss 7
Part, 5 parts of Herba Acalyphae, 3 parts of Rhizoma Paridis, 3 parts of Herba Centipedae.
Embodiment 6：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 33 parts of Mentholum, 23 parts of the Cortex Eucommiae, 23 parts of Radix Angelicae Pubescentiss, 23 parts of Rhizoma Et Radix Notopterygii, continue
Disconnected 27 parts, 33 parts of Radix Gentianae Macrophyllae, 27 parts of Moschus, 27 parts of Cornu Cervi Pantotrichum, 27 parts of Hippocampus, 23 parts of Scolopendra, 33 parts of Carapax Trionycis.
Embodiment 7：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 10 parts of Herba Monochoriae Korsakowii, 6 parts of Radix Lamiophlomidis Rotatae, 2.5 parts of Polygonum runcinatum var. sinense Hemsl., 5 parts of Cortex Phellodendri,
5 parts of Bao Tuancao, stand 4 parts of muscle grass, 7 parts of Myrrha (processed), 3 parts of Fructus Aurantii, Rhizoma Kaempferiae 3-4 part, Cacumen Myricariae Germanicae 10-20 part, 2.5 parts of Radix Rehmanniae Preparata, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5
Part, 2.5 parts of Flos Citri Sarcodactyliss, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, Semen Strychni 2-5 part, 7 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Folium Ricini and
15 parts of Herba Epilobii Angustifoii.
Embodiment 8：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 15 parts of Cacumen Myricariae Germanicae, 2.5 parts of Radix Rehmanniae Preparata, 5 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Citri Sarcodactyliss 2.5
Part, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, 3 parts of Semen Strychni, 7 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Folium Ricini and 15 parts of Herba Epilobii Angustifoii, white
15 parts of barral of a gun, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, 10 parts of Herba indigoferae bungeanae, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., 5 parts of Herba malachii aquatici, prolong
9 parts of Rhizoma Corydalis, Eupolyphaga Seu Steleophaga 1.5,4 parts of Herba Lycopi, 7 parts of Cortex cercis chinensiss, 5 parts of Herba Acalyphae, 3 parts of Rhizoma Paridis, 3 parts of Herba Centipedae.
Embodiment 9：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, Herba indigoferae bungeanae
10 parts, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., 5 parts of Herba malachii aquatici, 9 parts of Rhizoma Corydalis, Eupolyphaga Seu Steleophaga 1.5,4 parts of Herba Lycopi, 7 parts of Cortex cercis chinensiss, ferrum
5 parts of Amaranthus mangostanus L., 3 parts of Rhizoma Paridis, 3 parts of Herba Centipedae, 33 parts of Mentholum, 23 parts of the Cortex Eucommiae, 23 parts of Radix Angelicae Pubescentiss, 23 parts of Rhizoma Et Radix Notopterygii, continue disconnected
27 parts, 33 parts of Radix Gentianae Macrophyllae, 27 parts of Moschus, 27 parts of Cornu Cervi Pantotrichum, 27 parts of Hippocampus, 23 parts of Scolopendra, 33 parts of Carapax Trionycis.
Embodiment 10：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 10 parts of Herba Monochoriae Korsakowii, 7 parts of Radix Lamiophlomidis Rotatae, 2.5 parts of Polygonum runcinatum var. sinense Hemsl., 5 parts of Cortex Phellodendri,
5 parts of Bao Tuancao, stand muscle grass 4 parts, 7 parts of Myrrha (processed), 3 parts of Fructus Aurantii, 3.5 parts of Rhizoma Kaempferiae, 15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, Flos Woodfordiae Fruticosae
10 parts, 10 parts of Herba indigoferae bungeanae, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., 5 parts of Herba malachii aquatici, 9 parts of Rhizoma Corydalis, Eupolyphaga Seu Steleophaga 1.2,4 parts of Herba Lycopi,
7 parts of Cortex cercis chinensiss, 5 parts of Herba Acalyphae, 3 parts of Rhizoma Paridis, 3 parts of Herba Centipedae.
Embodiment 11：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 10 parts of Herba Monochoriae Korsakowii, 6 parts of Radix Lamiophlomidis Rotatae, 2.5 parts of Polygonum runcinatum var. sinense Hemsl., 5 parts of Cortex Phellodendri,
5 parts of Bao Tuancao, stand muscle grass 4 parts, 7 parts of Myrrha (processed), 3 parts of Fructus Aurantii, 3.5 parts of Rhizoma Kaempferiae, 33 parts of Mentholum, 23 parts of the Cortex Eucommiae, 23 parts of Radix Angelicae Pubescentiss,
23 parts of Rhizoma Et Radix Notopterygii, continue disconnected 27 parts, 33 parts of Radix Gentianae Macrophyllae, 27 parts of Moschus, 27 parts of Cornu Cervi Pantotrichum, 27 parts of Hippocampus, 23 parts of Scolopendra, 33 parts of Carapax Trionycis.
Embodiment 12：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, Cacumen Myricariae Germanicae 10-20 part, 2.5 parts of Radix Rehmanniae Preparata, 5 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Citri Sarcodactyliss
2.5 parts, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, 3 parts of Semen Strychni, 7 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Folium Ricini and 15 parts of Herba Epilobii Angustifoii,
33 parts of Mentholum, 23 parts of the Cortex Eucommiae, 23 parts of Radix Angelicae Pubescentiss, 23 parts of Rhizoma Et Radix Notopterygii, continue disconnected 27 parts, 33 parts of Radix Gentianae Macrophyllae, 27 parts of Moschus, 27 parts of Cornu Cervi Pantotrichum, sea
27 parts of horse, 23 parts of Scolopendra, 33 parts of Carapax Trionycis.
Embodiment 13：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 10 parts of Herba Monochoriae Korsakowii, 7 parts of Radix Lamiophlomidis Rotatae, 2.5 parts of Polygonum runcinatum var. sinense Hemsl., 5 parts of Cortex Phellodendri,
5 parts of Bao Tuancao, stand muscle grass 4 parts, 7 parts of Myrrha (processed), 3 parts of Fructus Aurantii, 3.5 parts of Rhizoma Kaempferiae, 15 parts of Cacumen Myricariae Germanicae, 2.5 parts of Radix Rehmanniae Preparata, 5 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi),
2.5 parts of Flos Citri Sarcodactyliss, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, 3 parts of Semen Strychni, 7 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Folium Ricini and red chopsticks
15 parts of son, 15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, 10 parts of Herba indigoferae bungeanae, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., goose intestinal
5 parts of dish, Rhizoma Corydalis 8-10 part, Eupolyphaga Seu Steleophaga 1.5,4 parts of Herba Lycopi, 7 parts of Cortex cercis chinensiss, 5 parts of Herba Acalyphae, 3 parts of Rhizoma Paridis, sandwort
3 parts of grass.
Embodiment 14：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, Cacumen Myricariae Germanicae 10-20 part, 2.5 parts of Radix Rehmanniae Preparata, 5 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Citri Sarcodactyliss
2.5 parts, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, 3 parts of Semen Strychni, 7 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Folium Ricini and 15 parts of Herba Epilobii Angustifoii,
15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, 10 parts of Herba indigoferae bungeanae, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., 5 parts of Herba malachii aquatici,
9 parts of Rhizoma Corydalis, Eupolyphaga Seu Steleophaga 1.5,4 parts of Herba Lycopi, 7 parts of Cortex cercis chinensiss, 5 parts of Herba Acalyphae, 3 parts of Rhizoma Paridis, 3 parts of Herba Centipedae, thin
33 parts of lotus brain, 23 parts of the Cortex Eucommiae, 23 parts of Radix Angelicae Pubescentiss, 23 parts of Rhizoma Et Radix Notopterygii, continue disconnected 27 parts, 33 parts of Radix Gentianae Macrophyllae, 27 parts of Moschus, 27 parts of Cornu Cervi Pantotrichum, Hippocampus
27 parts, 23 parts of Scolopendra, 33 parts of Carapax Trionycis.
Embodiment 15：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 10 parts of Herba Monochoriae Korsakowii, 7 parts of Radix Lamiophlomidis Rotatae, 2.5 parts of Polygonum runcinatum var. sinense Hemsl., 5 parts of Cortex Phellodendri,
5 parts of Bao Tuancao, stand 4 parts of muscle grass, 7 parts of Myrrha (processed), 3 parts of Fructus Aurantii, 3.5 parts of parts of Rhizoma Kaempferiae, 15 parts of Cacumen Myricariae Germanicae, 2.5 parts of Radix Rehmanniae Preparata, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5
Part, 2.5 parts of Flos Citri Sarcodactyliss, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, 2.5 parts of Semen Strychni, 7 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Folium Ricini and
15 parts of Herba Epilobii Angustifoii, 33 parts of Mentholum, 23 parts of the Cortex Eucommiae, 23 parts of Radix Angelicae Pubescentiss, 23 parts of Rhizoma Et Radix Notopterygii, continue disconnected 27 parts, 33 parts of Radix Gentianae Macrophyllae, 27 parts of Moschus,
27 parts of Cornu Cervi Pantotrichum, 27 parts of Hippocampus, 23 parts of Scolopendra, 33 parts of Carapax Trionycis.
Embodiment 16：
A kind of unguentum for preventing and treating closed fracture Tension Vesicle, including the following various components of mass fraction：
22 parts of charred Radix Sanguisorbae, 17 parts of Borneolum Syntheticum, 21 parts of Oleum sesami, 10 parts of Herba Monochoriae Korsakowii, 7 parts of Radix Lamiophlomidis Rotatae, 2.5 parts of Polygonum runcinatum var. sinense Hemsl., 5 parts of Cortex Phellodendri,
5 parts of Bao Tuancao, stand 4 parts of muscle grass, 7 parts of Myrrha (processed), 3 parts of Fructus Aurantii, 3.5 parts of Rhizoma Kaempferiae, Cacumen Myricariae Germanicae 10-20 part, 2.5 parts of Radix Rehmanniae Preparata, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5
Part, 2.5 parts of Flos Citri Sarcodactyliss, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, 3 parts of Semen Strychni, 7 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Folium Ricini and red
15 parts of chopsticks, 15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, 10 parts of Herba indigoferae bungeanae, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., goose
5 parts of intestinal dish, Rhizoma Corydalis 8-10 part, Eupolyphaga Seu Steleophaga 1.5,4 parts of Herba Lycopi, 7 parts of Cortex cercis chinensiss, 5 parts of Herba Acalyphae, 3 parts of Rhizoma Paridis, goose are not
Food grass 3 parts, 33 parts of Mentholum, 23 parts of the Cortex Eucommiae, 23 parts of Radix Angelicae Pubescentiss, 23 parts of Rhizoma Et Radix Notopterygii, continue disconnected 27 parts, 33 parts of Radix Gentianae Macrophyllae, 27 parts of Moschus, Cornu Cervi Pantotrichum
27 parts, 27 parts of Hippocampus, 23 parts of Scolopendra, 33 parts of Carapax Trionycis.
Embodiment 17：
A kind of preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle, deionized water is added in reaction pot,
Be heated to 62-78 DEG C, while stirring add 15 parts of Cortex Fraxini Malacophyllae Radiciss, 10 parts of Herba Monochoriae Korsakowii, 7 parts of Radix Lamiophlomidis Rotatae, 2.5 parts of Polygonum runcinatum var. sinense Hemsl., 5 parts of Cortex Phellodendri,
5 parts of Bao Tuancao, stand 4 parts of muscle grass, 7 parts of Myrrha (processed), 3 parts of Fructus Aurantii, Rhizoma Kaempferiae 3-4 part, mixing and stirring, continues to decoct while stirring
3h, filters to obtain decocting for Chinese herbal medicine liquid, places and processes 30 minutes, filter, obtain Chinese medicine extract solution at 10-28 DEG C, described
Chinese medicine extract solution is concentrated into relative density for 1.020-1.105 at 20 DEG C, obtains the first extract.
Embodiment 18：
A kind of preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle, by 15 parts of Cacumen Myricariae Germanicae, 2.5 parts of Radix Rehmanniae Preparata,
5 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), 2.5 parts of Flos Citri Sarcodactyliss, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, 3 parts of Semen Strychni, 7 parts of Radix Et Rhizoma Nardostachyos, Folium Ricini 6
After part and 15 parts of dryings of Herba Epilobii Angustifoii, coarser powder is ground into pulverizer, compares 1 according to water quality:5～1:7 are evenly mixed in band pot
Decoct in the pot of lid, big fire uses boiling with soft fire 1～5 hour or so after boiling again, leaches decocting liquid；So 2～3 times repeatedly, merge and decoct
Liquid, filters, and stands 15 hours, takes the supernatant and concentrate, obtain the second extract.
Embodiment 19：
A kind of preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle, 15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, shrimp
Son spend 10 parts, 10 parts of Herba indigoferae bungeanae, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., 5 parts of Herba malachii aquatici, 9 parts of Rhizoma Corydalis, Eupolyphaga Seu Steleophaga 1-2, Herba Lycopi 4
Part, 7 parts of Cortex cercis chinensiss, 5 parts of Herba Acalyphae, 3 parts of Rhizoma Paridis, 3 parts of crushing of Herba Centipedae, add ethanol, and heating in water bath flows back
0.5h, sucking filtration, filtering residue repeats aforesaid operations and processes twice, and merging filtrate filters impurity, is cooled to room temperature, sucking filtration, is concentrated to give the
Three extracts.
Embodiment 20：
A kind of preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle, 33 parts of Mentholum, 23 parts of the Cortex Eucommiae, Radix Angelicae Pubescentiss
23 parts, 23 parts of Rhizoma Et Radix Notopterygii, continue disconnected 27 parts, 33 parts of Radix Gentianae Macrophyllae, 27 parts of Moschus, 27 parts of Cornu Cervi Pantotrichum, 27 parts of Hippocampus, 23 parts of Scolopendra, 33 parts of Carapax Trionycis.
Crush, 95% alcohol-pickled for 3 times, merge ethanol extract, vacuum distillation obtains sepia extractum, moisture uses water, second after dissipating successively
Ether and ethyl acetate are extracted, and ethyl acetate portion vacuum distillation is concentrated to give the 4th extract.
The first extract of the present invention, the second extract, the 3rd extract and the 4th extract preparation method can be fine
The physical property according to product extracted, the active ingredient of reservation is many, preparation method is simple.
Embodiment 21：
A kind of preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle, Borneolum Syntheticum is placed in iron still, is added
Chinese liquor, heated and stirred is cooled to room temperature and is subsequently adding 17 parts of Borneolum Syntheticum and 21 parts of Oleum sesami, stir to 160-200 degree to 2h,
The first extract, the second extract, the 3rd extract or the 4th extract is added to be poured on plaster paper.
Embodiment 22：
Clinical pharrnacokinetics test is carried out to the medicine of the present invention, Details as Follows：
Object and method
It is object of study that convenient sampling method chooses 228 patients.Wherein male 158, female 68；At 12 85 years old age, put down
Equal (38.6 ± 6.5) years.Inclusion criteria：(1) clear and definite limb trauma history, x line piece shows fracture.(2) closed fracture is,
Skin complete, hinders limb with different degrees of swelling, and is unilateral limbs.(3) clients in 2～7h after injury, are both needed to operation
Treatment.(4) swelling degree is degree struttuer of I, II, III.Exclusion standard：(1) spiritedness, internal disease person.(2) there are nerve, blood
Pipe damages the wounded.(3) the pathologisch Bruch patient such as bone tumor, bone tuberculosis.(4) skin injury person.Observation group 100 is classified as at random
Example, matched group 126, two groups of patients are in the no significant difference P of the aspects such as sex, age, limb swelling degree>
0.05), with comparability.
Therapeutic Method matched group takes lifting affected limb, is placed in functional position, subside a swelling with aescine, Mannitol etc.,
Exudation Drug therapy；Treatment group uses the product for being prepared with embodiment 13 to 16.Observation group on the basis of matched group, with temperature
Water is waited to do after cleaning suffering limb naturally, avoids (then avoiding blister as formed blister, it is to avoid skin ulceration) at skin lesion, with beyond disease
Become 1～2cm of scope to be advisable, thickness about 1mm, and covered with sterile gauze, immobilization with adhesive tape, per 24h dressing once.After treatment end
Observe two groups of patients and have or not Tension Vesicle and formed, record blister forms rear regression time.
Observational technique timing observation daily has or not Tension Vesicle and is formed.Continuous monitoring 5d, by the same specialty
Nurse practitioner is responsible for observation and has or not blister formation and measurement blister diameter and record.Notice that observing area of coverage local skin has
The no anaphylaxiss such as skin rubefaction, prurituss.If any above-mentioned symptom, timely stopped treatment, observation group has 3 to occur anaphylaxiss to move back
Go out, the person of will move out includes intentional analysiss.
Swelling degree evaluation foundation《New Chinese medicine guideline of clinical investigations》With reference to symptoms of soft tissue injuries grade scale
Formulate.
Clinical efficacy evaluation criteria
Cure：When observation starts, established blister diameter no longer increases, and heals after suction therapy；Effectively：After 3～5d
No-station pole canopy blister is formed；Invalid：Observation starts to form Tension Vesicle in 2d, or the blister diameter for existing when observation starts
Continue to increase, formed after suction once again.
1 liang of group prevention Tension Vesicle of table forms effectiveness comparison example
Can be seen that from above-mentioned comparative example：Each component in the present invention has union of fracture and soft tissue healing
Effect, each group subassembly use when have collaboration effect, used reinforcing to which, and when being applied in combination, cure rate be bright
Powerful and influential higher than alone when cure rate.
Presently preferred embodiments of the present invention is the foregoing is only, not in order to limit the present invention, all essences in the present invention
Any modification, equivalent and improvement that is made within god and principle etc., should be included within the scope of the present invention.
Claims (10)
1. a kind of unguentum for preventing and treating closed fracture Tension Vesicle, it is characterised in that including following various groups of mass fraction
Part：
Charred Radix Sanguisorbae 10-30 part, Borneolum Syntheticum 10-25 part, Oleum sesami 15-30 part.
2. the unguentum for preventing and treating closed fracture Tension Vesicle according to claim 1, it is characterised in that
Also include the following various components of mass fraction：
10 parts of Herba Monochoriae Korsakowii, Radix Lamiophlomidis Rotatae 5-8 part, Polygonum runcinatum var. sinense Hemsl. 2-3 part, Cortex Phellodendri 4-6 part, Bao Tuancao 4-6 part, stand muscle grass 3-5 part, Myrrha (processed)
6-8 part, Fructus Aurantii 2-4 part, Rhizoma Kaempferiae 3-4 part.
3. the unguentum for preventing and treating closed fracture Tension Vesicle according to claim 1, it is characterised in that
Also include the following various components of mass fraction：Cacumen Myricariae Germanicae 10-20 part, Radix Rehmanniae Preparata 2-3 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 3-7 part, Flos Citri Sarcodactyliss 2-3
Part, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, 15 parts of Flos koelreuteriae paniculatae, Semen Strychni 2-5 part, Radix Et Rhizoma Nardostachyos 6-8 part, Folium Ricini 5-7 part and Herba Epilobii Angustifoii 15
Part.
4. the unguentum for preventing and treating closed fracture Tension Vesicle as claimed in any of claims 1 to 3, its feature exists
In also including mass fraction various components as follows：15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, 10 parts of Herba indigoferae bungeanae, people
7 10 parts, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., 5 parts of Herba malachii aquatici, Rhizoma Corydalis 8-10 part, Eupolyphaga Seu Steleophaga 1-2, Herba Lycopi's 3-5 part, Cortex cercis chinensiss 6-8 part, ferrum
Amaranthus mangostanus L. 4-6 part, Rhizoma Paridis 2-4 part, Herba Centipedae 2-4 part.
5. the unguentum for preventing and treating closed fracture Tension Vesicle according to claim 4, also includes that mass fraction is following
Various components：
Mentholum 15-50 part, Cortex Eucommiae 15-30 part, Radix Angelicae Pubescentiss 15-30 part, Rhizoma Et Radix Notopterygii 15-30 part, continue disconnected 15-40 part, Radix Gentianae Macrophyllae
15-50 part, Moschus 15-40 part, Cornu Cervi Pantotrichum 15-40 part, Hippocampus 15-40 part, Scolopendra 15-30 part, Carapax Trionycis 15-50 part.
6. a kind of preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle, it is characterised in that deionized water is added
In reaction pot, 62-78 DEG C is heated to, adds 15 parts of Cortex Fraxini Malacophyllae Radiciss, 10 parts of Herba Monochoriae Korsakowii, Radix Lamiophlomidis Rotatae 5-8 part, Polygonum runcinatum var. sinense Hemsl. 2-3 while stirring
Part, Cortex Phellodendri 4-6 part, Bao Tuancao 4-6 part, stand muscle grass 3-5 part, Myrrha (processed) 6-8 part, Fructus Aurantii 2-4 part, Rhizoma Kaempferiae 3-4 part, mix and blend
Uniformly, continue to decoct 3h while stirring, decocting for Chinese herbal medicine liquid is filtered to obtain, place at 10-28 DEG C and process 30 minutes, filter, obtain
Chinese medicine extract solution, described Chinese medicine extract solution is concentrated into relative density for 1.020-1.105 at 20 DEG C, obtains first
Extract.
7. the preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle according to claim 6, it is characterised in that
By Cacumen Myricariae Germanicae 10-20 part, Radix Rehmanniae Preparata 2-3 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 3-7 part, Flos Citri Sarcodactyliss 2-3 part, 15 parts of HERBA VERONICAE DILATATAE, 15 parts of Herba Tricyrtis Pilosae, Flos koelreuteriae paniculatae 15
After part, Semen Strychni 2-5 part, Radix Et Rhizoma Nardostachyos 6-8 part, Folium Ricini 5-7 part and 15 parts of dryings of Herba Epilobii Angustifoii, coarser powder is ground into pulverizer, presses
Compare 1 according to water quality:5～1:7 are evenly mixed in decoction in the pot with pot cover, and 1～5 hour left side of boiling with soft fire is used in big fire again after boiling
The right side, leaches decocting liquid；So 2～3 times repeatedly, collecting decoction, filters, stands 15 hours, take the supernatant and concentrate, obtain second
Extract.
8. the preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle according to claim 7, it is characterised in that
15 parts of Cortex Fraxini Malacophyllae Radiciss, 20 parts of Herba Heliotroph, 10 parts of Flos Woodfordiae Fruticosae, 10 parts of Herba indigoferae bungeanae, 10 parts of Rhizoma Tupistrae Chinensis, 10 parts of Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook., 5 parts of Herba malachii aquatici,
Rhizoma Corydalis 8-10 part, Eupolyphaga Seu Steleophaga 1-2, Herba Lycopi's 3-5 part, Cortex cercis chinensiss 6-8 part, Herba Acalyphae 4-6 part, Rhizoma Paridis 2-4 part, goose are not
Food grass 2-4 part is crushed, addition ethanol, heating in water bath backflow 0.5h, sucking filtration, and filtering residue repeats aforesaid operations and processes twice, merges and filters
Liquid, filters impurity, is cooled to room temperature, and sucking filtration is concentrated to give the 3rd extract.
9. the preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle according to claim 8,
Characterized in that, Mentholum 15-50 part, Cortex Eucommiae 15-30 part, Radix Angelicae Pubescentiss 15-30 part, Rhizoma Et Radix Notopterygii 15-30 part, continue disconnected 15-
40 parts, Radix Gentianae Macrophyllae 15-50 part, Moschus 15-40 part, Cornu Cervi Pantotrichum 15-40 part, Hippocampus 15-40 part, Scolopendra 15-30 part, Carapax Trionycis
15-50 part.Crush, 95% alcohol-pickled for 3 times, merge ethanol extract, vacuum distillation obtains sepia extractum, moisture dissipate after according to
Secondary use water, ether and ethyl acetate are extracted, and ethyl acetate portion vacuum distillation is concentrated to give the 4th extract.
10. the preparation method of the unguentum for preventing and treating closed fracture Tension Vesicle according to claim 9, its feature exists
In, Borneolum Syntheticum being placed in iron still, Chinese liquor is added, heated and stirred is cooled to room temperature and is subsequently adding ice to 160-200 degree to 2h
Piece 10-25 part and Oleum sesami 15-30 part, stir, and add the first extract, the second extract, the 3rd extract or the 4th to carry
Take thing to be poured on plaster paper.
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