CN105434748A - Pharmaceutical composition for treating injured limb edema after apoplexy hemiplegia - Google Patents
Pharmaceutical composition for treating injured limb edema after apoplexy hemiplegia Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine, and particularly, relates to a pharmaceutical composition for treating injured limb edema after apoplexy hemiplegia. The pharmaceutical composition is composed of the following traditional Chinese medicines in parts by weight: 4-6 parts of fructus livistonae, 4-6 parts of fewflower lysionotus herb, 4-6 parts of herba pimpinellae, 4-6 parts of pentasachme caudatum, 4-6 parts of tuber of serrate sikoku jackinthepulpit, 4-6 parts of naked pronephrium nudatum, 4-6 parts of all-grass of winkled marshweed, 4-6 of root of perny germander, 4-6 parts of lespedeza pilosa, and 4-6 parts of leaf of lance coreopsis. Various drugs are combined for use and together play the efficacies of clearing away heat and toxic materials, promoting blood circulation to remove meridian obstruction, dispersing blood stasis and eliminating stagnation, and relieving swelling and pain; and the pharmaceutical composition is used for treating injured limb edema after apoplexy hemiplegia, and has the advantages of good curative effect and short healing time.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of suffering limb edema after apoplectic hemiplegia.
Background technology
Apoplexy is commonly encountered diseases, the frequently-occurring disease of Neurology Department, a part of patient because of paralyzed limbs limitation of activity, the reasons such as thrombosis, occur paralysis suffering limb edema, principal character is suffering limb edema, is very especially with acra, hemiplegia suffering limb edema can affect the rehabilitation training of patient, extends the course of disease.Have not yet to see the medicine being exclusively used in suffering limb edema after apoplectic hemiplegia.
Summary of the invention
Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of pharmaceutical composition for the treatment of suffering limb edema after apoplectic hemiplegia.
The present invention is achieved through the following technical solutions:
Treat a pharmaceutical composition for suffering limb edema after apoplectic hemiplegia, be made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.
Preferably, the pharmaceutical composition of suffering limb edema after above-mentioned treatment apoplectic hemiplegia, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.
Preferred, the pharmaceutical composition of suffering limb edema after above-mentioned treatment apoplectic hemiplegia, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.
The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.
The indication of medicine of the present invention: be used for the treatment of suffering limb edema after apoplectic hemiplegia.
The method of preparation and use of medicine of the present invention: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.
The standard of fine powder is on the books in Chinese Pharmacopoeia 2010 editions 1 annex.
The taboo item of medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.
In medicine of the present invention,
Chinese fanpalm seed another name seed of Livistona chinensis R.Br. is babassu Semen livistonae chinensis Livistonachinensis(Jacq.) seed of R.Br..Sweet in the mouth; Bitter; Property is put down.Function blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.
The black black bone of Herba Lysionoti Pauciflori another name, Radix Loxostigmatis griffithii, Lysionotus pauciflorus Maxim., little Herba Lycopi, Herba Lysionoti carnosae, rock tea, Herba Ophiorrhizae japonicae, rock orchid, Ba Yancao, the red grass of lung, Semen Benincasae grass, Parmelia saxatilis Ach., puerperal tea, Eupatorium formosanum Hayata., stone Radix Notoginseng, Shi Hu, Cicerbita azurea (Ledeb.) Beavuerd, Radix Loxostigmatis griffithii, stone Fructus Myricae rubrae, rock head Radix Notoginseng, rock strip, bamboo do not sting, member orchid, pattern rake.For the herb of Gesneriaceae Herba Lysionoti Pauciflori LysionotuspauciflorusMaxim..Bitter in the mouth; Pungent; Property is put down.Function wind dehumidifies; Preventing phlegm from forming and stopping coughing; Blood stasis dispelling stimulates the menstrual flow.Main air pain of dampness syndrome; Cough with asthma abundant expectoration; Menoxenia; Dysmenorrhea; Traumatic injury.
That Radix Pimpinellae Candolleanae another name Rhizoma valerianae latifoliae, mountain Radix Angelicae Sinensis, Horse hoof Radix Saposhnikoviae, JIUYUE Pemisetum flaccidum Griseb, all over the body string, tripodia Cicadae, Pemisetum flaccidum Griseb, Yangshan are smelly, Rhizoma typhonii divaricati, clearly Radix Angelicae Sinensis, sheep are had a strong smell is smelly, Herba Calthae, Fructus Piperis, lamb have a strong smell, Radix Pimpinellae Candolleanae, nine Ns dry, sheep mountain is smelly, Great Cold medicine, grass of cooling down, rabbit ear Radix Saposhnikoviae, little hero, little Flos Chrysanthemi, be root or the herb of samphire Folium Pruni Pimpinella anisum Linn. PimpinellacandolleanaWighy day Arn.Acrid in the mouth; Micro-hardship; Warm in nature.Return lung; Spleen; Stomach; Liver Channel.Function warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling.The cold pain of main gastral cavity abdomen; Dyspepsia; Dysentery; Flu; Cough; Infantile convulsion; Leucorrhea; Hernia; The testis swelling and hanging down of either of the testes; Scrofula; Treating swelling and pain by traumatic injury; Carbuncle sore tumefacting virus; Venom.
Radix Pentasacmi championii another name five, southern stone Herba seu Radix Metaplexis hemsleyanae, false fourth Diao Zhu, Herba Pteridis Multifidae, full grass, Radix Homonoiae Ripariae, be the herb of dicotyledon medicine asclepiadaceae stone Herba seu Radix Metaplexis hemsleyanae PendasacmechampioniiBenth..Bitter in the mouth; Micro-pungent; Cool in nature.Return liver; Gallbladder meridian.Function is fallen apart wind heat clearing away; Removing toxic substances and promoting subsidence of swelling.Main anemopyretic cold; Cough; Pharyngalgia; Conjunctival congestion; Hepatitis; Venom.
Rhizoma Arisaemati another name LUBIANHUANG, Serpentis Semen Maydis, old Serpentis Semen Maydis are the tuber of aroid Rhizoma Arisaemati ArisaemasikokianumFuanch. day or full edge Rhizoma Arisaemati Sav.var.s day tatum (Makino) Hand.-Mazz [A.sazensoovar.serratumMakino] 2.ArisaemasikokianumFranch. day Sav..Bitter in the mouth, pungent; Warm in nature.Return lung; Liver Channel.Function drying dampness to eliminate phlegm; Relieving spasm by subduing liver-wind; Reducing swelling and alleviating pain.Main productive cough due to phlegm-damp; Dizziness due to wind-phlegm; Epilepsy; Apoplexy; Facial hemiparalysis; Tetanus; Carbuncle; Venom.
Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching calls large plumage crescent Herba pteridii latiusculi, Coniogramme japonica (Thunb.) Diels, derives from fern Athyriaceae Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching Abacopterismultilineata(Wall.) Ching, is used as medicine with root stock.Bitter in the mouth, cold in nature.Function dredge the meridian passage, dampness removing of regulating the flow of vital energy.Cure mainly impairment caused by overstrain, peratodynia, dysentery, menoxenia.
Herba Limnophilae rugosae another name Tian Gencao, water mint, Rhizoma begoniae pedatifidae, water Herba Schizonepetae, ripples perfume, wrinkle leaf Herba Limnophilae sessiliflorae are the herb of goatweed Limnophila rugosa NitellaexpansaAllen, Limnophilarugosa (Roth) Merr..Acrid in the mouth; Sweet; Warm in nature.Return lung; Spleen; Stomach warp.Function invigorating spleen to remove dampness; Activating QI to eliminate phlegm.Main edema; Stomachache; Distension and fullness of the chest and abdomen; Cough; Children's's infantile dyspepsia; Furuncle.
Radix Teucrii Pernyi another name Mount Lushan spice, derives from Labiatae and spends Phryganeajaponica Ml. TeucriumpernyiFranch. in vain, be used as medicine with root.Taste is micro-sweet, warm in nature.Function invigorating spleen to remove dampness, removing toxic substances.Cure mainly dysentery.
Herba lespedezae pilosae another name Herba cassiae torae, derives from pulse family Lespedeza plant Herba lespedezae pilosae Lespedezapilosa(Thunb.) Sieb. day Zucc., is used as medicine with root and Herb.Bitter in the mouth, pungent, property is put down.Function heat clearing away eliminating stagnation, promoting blood circulation and stopping pain, line water detumescence.For lymphoid tuberculosis, cold abscess, deficiency-heat is not moved back, edema, waist hamstring osteodynia; Mastitis are controlled in external.
Folium Coreopsis lanceolatae another name Coreopsis lanceolata, sword-like leave coreopsis, derive from Compositae Folium Coreopsis lanceolatae CoreopsislanceolataL., with all herbal medicine.Acrid in the mouth, property is put down.Function blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.Cure mainly knife injury, innominate toxic swelling.
In medicine of the present invention, Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; Herba Lysionoti Pauciflori heat clearing and damp drying, reducing swelling and alleviating pain; Radix Pimpinellae Candolleanae promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling; Radix Pentasacmi championii falls apart wind heat clearing away, removing toxic substances and promoting subsidence of swelling; Rhizoma Arisaemati drying dampness to eliminate phlegm, reducing swelling and alleviating pain; Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching dredge the meridian passage, regulating QI to expel dampness; Herba Limnophilae rugosae, Radix Teucrii Pernyi invigorating spleen to remove dampness, activating QI to eliminate phlegm; Herba lespedezae pilosae heat clearing away eliminating stagnation, promoting blood circulation and stopping pain; Folium Coreopsis lanceolatae blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.All medicines share, and play heat-clearing and toxic substances removing altogether, promoting blood circulation to remove obstruction in the collateral, blood stasis-eliminating and stagnation-dissipating, the effect of reducing swelling and alleviating pain.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Treat a pharmaceutical composition for suffering limb edema after apoplectic hemiplegia, each crude drug weight proportion is as follows:
Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 60g.
Method of preparation and use: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.
Embodiment 2
Treat a pharmaceutical composition for suffering limb edema after apoplectic hemiplegia, each crude drug weight proportion is as follows:
Chinese fanpalm seed 50g, Herba Lysionoti Pauciflori 70g, Radix Pimpinellae Candolleanae 50g, Radix Pentasacmi championii 70g, Rhizoma Arisaemati 50g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 70g, Herba Limnophilae rugosae 50g, Radix Teucrii Pernyi 70g, Herba lespedezae pilosae 50g, Folium Coreopsis lanceolatae 70g.
Method of preparation and use is with embodiment 1.
Embodiment 3
Treat a pharmaceutical composition for suffering limb edema after apoplectic hemiplegia, each crude drug weight proportion is as follows:
Chinese fanpalm seed 70g, Herba Lysionoti Pauciflori 50g, Radix Pimpinellae Candolleanae 70g, Radix Pentasacmi championii 50g, Rhizoma Arisaemati 70g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 50g, Herba Limnophilae rugosae 70g, Radix Teucrii Pernyi 50g, Herba lespedezae pilosae 70g, Folium Coreopsis lanceolatae 50g.
Method of preparation and use is with embodiment 1.
Embodiment 4
Treat a pharmaceutical composition for suffering limb edema after apoplectic hemiplegia, each crude drug weight proportion is as follows:
Chinese fanpalm seed 40g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 40g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 40g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 40g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 40g, Folium Coreopsis lanceolatae 60g.
Method of preparation and use is with embodiment 1.
Embodiment 5
Treat a pharmaceutical composition for suffering limb edema after apoplectic hemiplegia, each crude drug weight proportion is as follows:
Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 40g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 40g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 40g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 40g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 40g.
Method of preparation and use is with embodiment 1.
Carried out clinical pharrnacokinetics test to medicine of the present invention, Details as Follows:
1 clinical data
1.1 diagnostic criterias (1) all have the medical history of apoplexy and the symptom of hemiplegia, and all after CT or MRI checks, are diagnosed as Hemiplegic Patients, simultaneously with suffering limb edema in various degree; (2) according to the main suit of patient, sign, hemiplegia edematous site is divided into 3 grades.I level: Mild edema, namely edema can tolerate, and does not affect the functional activity of hemiplegic limb.II grade: intermediate edema, namely edema is heavier, and patient feels that limbs suppress swollen discomfort, the activity of restriction hemiplegic limb.III grade: severe edema, namely edema is serious, and patient feels that limbs suppress swollen can not tolerance, has a strong impact on the activity of hemiplegic limb.
1.2 inclusive criterias (1) meet the diagnostic criteria of acute cerebrovascular disease; (2) diagnostic criteria of apoplexy in Chinese medicine is met; (3) standard of hemiplegia suffering limb edema is left over after meeting apoplexy.
1.3 exclusion standards (1) do not meet inclusive criteria; (2) because intravenous medicine exosmoses the edema person caused; (3) the edema person that causes of cardio-pulmonary function.
The routine case of 1.4 physical data 60 all meets diagnostic criteria, and with edematous condition in various degree.Wherein Cerebral Infarction in 46 Cases, cerebral hemorrhage 14 example; Man 34 example, female 26 example; Age 45-75 year; Left side upper and lower extremities edema person 21 example, right side upper and lower extremities edema person 39 example; The shortest l0d of the course of disease, the longest 2 months.Be divided into treatment group and matched group at random, often organize 30 examples.Two groups of Genders, age and courses of disease compare, and the equal not statistically significant of difference (P < 0.05), has comparability.
2 research methoies
2.1 GP TH
2.1.1 matched group routine gives oral drugs and vein treatment administration, every day oral hydrochlorothiazide 2Omg, triamterene 50mg, 2 times/d, and coordinate apply acupuncture, rehabilitation, massage and risk of stroke control medication etc., treatment is carried out all routinely.
2.1.2 treatment group is on the basis of matched group conventional treatments, adds the edematous site of the fine drug powder external application suffering limb by the embodiment of the present invention 1.Concrete grammar is: assisting patients gets suitable position, expose affected part, the fine drug powder of the embodiment of the present invention 1 is poured in treatment bowl, be modulated into pasty state with Chinese liquor, according to the position of suffering limb edema, get sizeable gauze, divide with ointment cutter on gauze by required medicaments uniformity, thickness is moderate, affected part is spread on by after the gauze surrounding opisthotonos having spread out medicine, in order to avoid medicine overflows because being heated and pollutes clothing, add a cover dressing or cotton pad, fix with adhesive plaster or binder.The drug of topical application is complete, and assisting patients is worn clothes, strengthens warming.Notice that skin allergy person is cautious use of, the drug of topical application answers thickness even, and fixing degree of tightness is suitable for, and drug of topical application area must be greater than affected part, and should keep certain humidity, and time as more dry in medicine, the blender needed for application carries out moistening.Drug of topical application apparatus used all should be sterilized for subsequent use.1-2 external application every day, depends on dose according to edematous site size, and 20d is 1 course for the treatment of, and disappearing with edema is as the criterion.
2.2 nursing content two groups patients all strengthen basic nursing, suitably raise swelling suffering limb to improve blood circulation, carry out the skin nursing at suffering limb swelling position, keep the clean of the smooth and drug of topical application position of Bed unit, strengthen nutrition of whole body situation, enhancing body resistance, carries out the nursing of diet and medicine, health education and TCM psychiatry nursing simultaneously.
The treatment time of 2.3 observation index two groups is 20d, observes and records self sensation etc. of the pressing depression situation of suffering limb edematous site, skin temperature, limb activity function, limbs distending pain, the weak and limp situation of limbs and patient.
2.4 criterion of therapeutical effect recoveries from illness: patient's edema disappears completely, and limb activity improves; Effective: suffering limb edema disappears substantially, and limb activity obviously improves, Myodynamia recovery more than 4 grades, life is taken care of oneself substantially; Effective: suffering limb edema alleviates to some extent, and limb activity makes moderate progress, Myodynamia recovery more than 3 grades; Invalid: suffering limb edema and limb activity increase the weight of without improving or having.
2.5 statistical methods use SPSS16.0 statistics software, and measurement data adopts t inspection, and ranked data adopt Wilcoxon rank test, inspection level α=0.05.
3 results
2.1 liang of group comparitive study are in table 1.
Table 1 liang group comparitive study
Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
Treatment group | 30 | 10 | 12 | 6 | 2 | 93.33* |
Matched group | 30 | 5 | 8 | 8 | 9 | 70.00 |
Note: compared with matched group, * P < 0.05.
2.2 liang of group healing times compare
Treatment group average cure time is 15.2 ± 2.5 days, and matched group average time is 18.9 ± 3.4 days.Two groups are compared in healing time, and difference has statistical significance (P<O.05).
The curative effect of two groups is through rank test, and difference has statistical significance (P<0.05).Two groups are compared in healing time, and difference has statistical significance (P<O.05), illustrate that treatment group is all better than matched group at therapeutic effect with in treatment time.
Claims (3)
1. treat a pharmaceutical composition for suffering limb edema after apoplectic hemiplegia, be made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.
2. the pharmaceutical composition of suffering limb edema after treatment apoplectic hemiplegia according to claim 2, is characterized in that, be made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.
3. the pharmaceutical composition of suffering limb edema after treatment apoplectic hemiplegia according to claim 2, is characterized in that, be made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US20090104295A1 (en) * | 2005-08-12 | 2009-04-23 | Kenji Kohno | Agent for Hair Growth |
CN103463495A (en) * | 2013-09-23 | 2013-12-25 | 陈军 | Drug for treating senile postoperative acute mental disorders |
CN103463496A (en) * | 2013-09-23 | 2013-12-25 | 祝爱莲 | Drug for treating ankylosing spondylitis |
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2015
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090104295A1 (en) * | 2005-08-12 | 2009-04-23 | Kenji Kohno | Agent for Hair Growth |
CN103463495A (en) * | 2013-09-23 | 2013-12-25 | 陈军 | Drug for treating senile postoperative acute mental disorders |
CN103463496A (en) * | 2013-09-23 | 2013-12-25 | 祝爱莲 | Drug for treating ankylosing spondylitis |
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Application publication date: 20160330 |