CN105362568A - Medicine composition for treating internal arteriovenous fistula hematoma - Google Patents

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a medicine composition for treating internal arteriovenous fistula hematoma. The medicine composition is prepared from, by weight, 4-6 parts of Chinese fan palm seeds, 4-6 parts of fewflower lysionotus herbs, 4-6 parts of pimpinella candolleana, 4-6 parts of pentasacme championii benth., 4-6 parts of arisaema sikokianum Franch., 4-6 parts of nude pronephrium rhizomes, 4-6 parts of all-grass of winkled marshweed, 4-6 parts of roots of perny germander, 4-6 parts of rhamnus aurea and 4-6 parts of leaves of Lance coreopsis. All the herbs are used in combination to achieve the effects of clearing away heat and toxic materials, promoting blood circulation to remove meridian obstruction, removing blood stasis and eliminating stagnation and relieving swelling and pain. The medicine composition is used for treating internal arteriovenous fistula hematoma, and can improve blood circulation of surrounding tissue, enhance metabolism and promote swell disappearing and skin color recovery when applied to skin around internal arteriovenous fistula hematoma in a wet compressing mode.

Description

A kind of pharmaceutical composition for the treatment of internal arteriovenous fistula hematoma

Technical field

The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of internal arteriovenous fistula hematoma.

Background technology

Hemodialysis (hemodialysis.HD) the kidney replacement therapy method that chronic renal insufficiency patient depends on for existence is remained at present.It is ensure that hemodialysis carries out smoothly and affects the key factor of hemodialysis effect that dialysis vascular access then becomes patient's requisite " life line " vascular access.Maintenance hemodialysis (maintenancehemodialysis.MHD) need set up chronic vascular path, i.e. permanent vascular access, to ensure the adequacy of dialysing, extends the life cycle of MHD patient.Permanent vascular access comprises: the long-term conduit of Autogenous arteriovenous internal fistula (outogenousarteriovenousfistula, AVF), grafting vessel hemodialysis path, band polyester circular.Wherein AVF is the permanent vascular access of the hemodialysis patients first-selection that NKF-K/DOQI clinical practice guideline is recommended.Estimate to use the patient of Autogenous arteriovenous internal fistula more than 66% at present, vascular access is unobstructed. and blood flow enough could maintain normal hemodialysis.And the hematoma occurred in internal fistula use procedure has a strong impact on its use.For the process of internal fistula hematoma, towel hot-wet compress is used after pin 24h is pulled out in many employings clinically at present, after hot compress. also massage 5-10min gently at hematoma partial smearing hirudiod, until ointment all absorbs through skin, every day carries out 3-4 time, hematoma dissipates and the effect of pain relief is not very desirable, especially to hematoma larger area, takes effect very micro-.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of pharmaceutical composition for the treatment of internal arteriovenous fistula hematoma.

The present invention is achieved through the following technical solutions:

A pharmaceutical composition for treatment internal arteriovenous fistula hematoma, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.

Preferably, the pharmaceutical composition of above-mentioned treatment treatment internal arteriovenous fistula hematoma, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.

Preferred, the pharmaceutical composition of above-mentioned treatment treatment internal arteriovenous fistula hematoma, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of medicine of the present invention: be used for the treatment for the treatment of internal arteriovenous fistula hematoma.

The method of preparation and use of medicine of the present invention: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.

The standard of fine powder is on the books in Chinese Pharmacopoeia 2010 editions 1 annex.

The taboo item of medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In medicine of the present invention,

Chinese fanpalm seed another name seed of Livistona chinensis R.Br. is babassu Semen livistonae chinensis Livistonachinensis(Jacq.) seed of R.Br..Sweet in the mouth; Bitter; Property is put down.Function blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.

The black black bone of Herba Lysionoti Pauciflori another name, Radix Loxostigmatis griffithii, Lysionotus pauciflorus Maxim., little Herba Lycopi, Herba Lysionoti carnosae, rock tea, Herba Ophiorrhizae japonicae, rock orchid, Ba Yancao, the red grass of lung, Semen Benincasae grass, Parmelia saxatilis Ach., puerperal tea, Eupatorium formosanum Hayata., stone Radix Notoginseng, Shi Hu, Cicerbita azurea (Ledeb.) Beavuerd, Radix Loxostigmatis griffithii, stone Fructus Myricae rubrae, rock head Radix Notoginseng, rock strip, bamboo do not sting, member orchid, pattern rake.For the herb of Gesneriaceae Herba Lysionoti Pauciflori LysionotuspauciflorusMaxim..Bitter in the mouth; Pungent; Property is put down.Function wind dehumidifies; Preventing phlegm from forming and stopping coughing; Blood stasis dispelling stimulates the menstrual flow.Main air pain of dampness syndrome; Cough with asthma abundant expectoration; Menoxenia; Dysmenorrhea; Traumatic injury.

That Radix Pimpinellae Candolleanae another name Rhizoma valerianae latifoliae, mountain Radix Angelicae Sinensis, Horse hoof Radix Saposhnikoviae, JIUYUE Pemisetum flaccidum Griseb, all over the body string, tripodia Cicadae, Pemisetum flaccidum Griseb, Yangshan are smelly, Rhizoma typhonii divaricati, clearly Radix Angelicae Sinensis, sheep are had a strong smell is smelly, Herba Calthae, Fructus Piperis, lamb have a strong smell, Radix Pimpinellae Candolleanae, nine Ns dry, sheep mountain is smelly, Great Cold medicine, grass of cooling down, rabbit ear Radix Saposhnikoviae, little hero, little Flos Chrysanthemi, be root or the herb of samphire Folium Pruni Pimpinella anisum Linn. PimpinellacandolleanaWighy day Arn.Acrid in the mouth; Micro-hardship; Warm in nature.Return lung; Spleen; Stomach; Liver Channel.Function warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling.The cold pain of main gastral cavity abdomen; Dyspepsia; Dysentery; Flu; Cough; Infantile convulsion; Leucorrhea; Hernia; The testis swelling and hanging down of either of the testes; Scrofula; Treating swelling and pain by traumatic injury; Carbuncle sore tumefacting virus; Venom.

Radix Pentasacmi championii another name five, southern stone Herba seu Radix Metaplexis hemsleyanae, false fourth Diao Zhu, Herba Pteridis Multifidae, full grass, Radix Homonoiae Ripariae, be the herb of dicotyledon medicine asclepiadaceae stone Herba seu Radix Metaplexis hemsleyanae PendasacmechampioniiBenth..Bitter in the mouth; Micro-pungent; Cool in nature.Return liver; Gallbladder meridian.Function is fallen apart wind heat clearing away; Removing toxic substances and promoting subsidence of swelling.Main anemopyretic cold; Cough; Pharyngalgia; Conjunctival congestion; Hepatitis; Venom.

Rhizoma Arisaemati another name LUBIANHUANG, Serpentis Semen Maydis, old Serpentis Semen Maydis are the tuber of aroid Rhizoma Arisaemati ArisaemasikokianumFuanch. day or full edge Rhizoma Arisaemati Sav.var.s day tatum (Makino) Hand.-Mazz [A.sazensoovar.serratumMakino] 2.ArisaemasikokianumFranch. day Sav..Bitter in the mouth, pungent; Warm in nature.Return lung; Liver Channel.Function drying dampness to eliminate phlegm; Relieving spasm by subduing liver-wind; Reducing swelling and alleviating pain.Main productive cough due to phlegm-damp; Dizziness due to wind-phlegm; Epilepsy; Apoplexy; Facial hemiparalysis; Tetanus; Carbuncle; Venom.

Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching calls large plumage crescent Herba pteridii latiusculi, Coniogramme japonica (Thunb.) Diels, derives from fern Athyriaceae Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching Abacopterismultilineata(Wall.) Ching, is used as medicine with root stock.Bitter in the mouth, cold in nature.Function dredge the meridian passage, dampness removing of regulating the flow of vital energy.Cure mainly impairment caused by overstrain, peratodynia, dysentery, menoxenia.

Herba Limnophilae rugosae another name Tian Gencao, water mint, Rhizoma begoniae pedatifidae, water Herba Schizonepetae, ripples perfume, wrinkle leaf Herba Limnophilae sessiliflorae are the herb of goatweed Limnophila rugosa NitellaexpansaAllen, Limnophilarugosa (Roth) Merr..Acrid in the mouth; Sweet; Warm in nature.Return lung; Spleen; Stomach warp.Function invigorating spleen to remove dampness; Activating QI to eliminate phlegm.Main edema; Stomachache; Distension and fullness of the chest and abdomen; Cough; Children's's infantile dyspepsia; Furuncle.

Radix Teucrii Pernyi another name Mount Lushan spice, derives from Labiatae and spends Phryganeajaponica Ml. TeucriumpernyiFranch. in vain, be used as medicine with root.Taste is micro-sweet, warm in nature.Function invigorating spleen to remove dampness, removing toxic substances.Cure mainly dysentery.

Herba lespedezae pilosae another name Herba cassiae torae, derives from pulse family Lespedeza plant Herba lespedezae pilosae Lespedezapilosa(Thunb.) Sieb. day Zucc., is used as medicine with root and Herb.Bitter in the mouth, pungent, property is put down.Function heat clearing away eliminating stagnation, promoting blood circulation and stopping pain, line water detumescence.For lymphoid tuberculosis, cold abscess, deficiency-heat is not moved back, edema, waist hamstring osteodynia; Mastitis are controlled in external.

Folium Coreopsis lanceolatae another name Coreopsis lanceolata, sword-like leave coreopsis, derive from Compositae Folium Coreopsis lanceolatae CoreopsislanceolataL., with all herbal medicine.Acrid in the mouth, property is put down.Function blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.Cure mainly knife injury, innominate toxic swelling.

In medicine of the present invention, Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; Herba Lysionoti Pauciflori heat clearing and damp drying, reducing swelling and alleviating pain; Radix Pimpinellae Candolleanae promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling; Radix Pentasacmi championii falls apart wind heat clearing away, removing toxic substances and promoting subsidence of swelling; Rhizoma Arisaemati drying dampness to eliminate phlegm, reducing swelling and alleviating pain; Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching dredge the meridian passage, regulating QI to expel dampness; Herba Limnophilae rugosae, Radix Teucrii Pernyi invigorating spleen to remove dampness, activating QI to eliminate phlegm; Herba lespedezae pilosae heat clearing away eliminating stagnation, promoting blood circulation and stopping pain; Folium Coreopsis lanceolatae blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.All medicines share, and play heat-clearing and toxic substances removing altogether, promoting blood circulation to remove obstruction in the collateral, blood stasis-eliminating and stagnation-dissipating, the effect of reducing swelling and alleviating pain.Soak internal arteriovenous fistula perihematoma skin, can improve surrounding tissue blood circulation, strengthens metabolism, promotes that swelling is disappeared and the recovery of skin color.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

A pharmaceutical composition for treatment internal arteriovenous fistula hematoma, each crude drug weight proportion is as follows:

Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 60g.

Method of preparation and use: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.

Embodiment 2

A pharmaceutical composition for treatment internal arteriovenous fistula hematoma, each crude drug weight proportion is as follows:

Chinese fanpalm seed 50g, Herba Lysionoti Pauciflori 70g, Radix Pimpinellae Candolleanae 50g, Radix Pentasacmi championii 70g, Rhizoma Arisaemati 50g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 70g, Herba Limnophilae rugosae 50g, Radix Teucrii Pernyi 70g, Herba lespedezae pilosae 50g, Folium Coreopsis lanceolatae 70g.

Method of preparation and use is with embodiment 1.

Embodiment 3

A pharmaceutical composition for treatment internal arteriovenous fistula hematoma, each crude drug weight proportion is as follows:

Chinese fanpalm seed 70g, Herba Lysionoti Pauciflori 50g, Radix Pimpinellae Candolleanae 70g, Radix Pentasacmi championii 50g, Rhizoma Arisaemati 70g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 50g, Herba Limnophilae rugosae 70g, Radix Teucrii Pernyi 50g, Herba lespedezae pilosae 70g, Folium Coreopsis lanceolatae 50g.

Method of preparation and use is with embodiment 1.

Embodiment 4

A pharmaceutical composition for treatment internal arteriovenous fistula hematoma, each crude drug weight proportion is as follows:

Chinese fanpalm seed 40g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 40g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 40g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 40g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 40g, Folium Coreopsis lanceolatae 60g.

Method of preparation and use is with embodiment 1.

Embodiment 5

A pharmaceutical composition for treatment internal arteriovenous fistula hematoma, each crude drug weight proportion is as follows:

Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 40g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 40g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 40g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 40g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 40g.

Method of preparation and use is with embodiment 1.

Carried out clinical pharrnacokinetics test to medicine of the present invention, Details as Follows:

1 data and method

1.1l clinical data

In the patient of the equal behavior rule hemodialysis of 132 routine patient, during the treatment caused because of a variety of causes and after treatment, internal arteriovenous fistula surrounding subcutaneous hematoma person occurs, wherein man 50 example, female 82 example, at 19 ~ 76 years old age, internal fistula type is Autogenous arteriovenous internal fistula.Direct internal fistula 107 example of radial artery-cephalic vein wrist, anatomical snuff-box internal fistula 22 example, forearm ulnar artery-basilic vein internal fistula 3 example, wherein radial artery-cephalic vein end-to-side anastomosis is as the first-selection setting up chronic hemodialysis path.Internal fistula uses first as postoperative 4 ~ 12 weeks, dialyses weekly 2 ~ 3 times.Blood flow (200 ~ 250) mL/min.The principle following random controls is divided into seminar and matched group, often organizes each 66 examples, two groups of patients no significant difference in sex, age, dialysis ages etc.Three types is divided into: < 5cm, 5 ~ 10cm, > 10cm according to hematoma scope.The various hematoma type proportions that patient occurs. two group difference not statistically significants (P > 0.05).

1.2 method

1.2.1 normal press after matched group generation ecchymosis, ice bag cold compress affected part after hemostasis, (towel temperature keeps 50 DEG C ~ 60 DEG C to use towel to carry out local hot-wet compress after pulling out pin 24h, each hot compress 20 ~ 30min), after hot compress, massage 5 ~ 10min gently at hematoma partial smearing hirudiod (German MobilatProduktionsGmbH, registration certificate H20150011), until ointment all absorbs through skin, every day carries out 3 ~ 4 times.Until ecchymosis disappears.

1.2.2 when there is ecchymosis in seminar, pressure hemostasis is the same, after pulling out pin 24h, the pharmaceutical composition fine powder Mel of the embodiment of the present invention 1 or green tea are mixed well into sposh shape (being advisable not flow downward after smearing), avoid puncture needle eye, with cotton swab by its uniform application in Hemorrhagic location skin, thickness is about 1 ~ 2mm evenly.With gauze, the medicine place of smearing the embodiment of the present invention 1 is wrapped up gently again.Avoid wiping during patient activity.Change 2 ~ 3 every day.

1.3 the standard of curative effect evaluation

(1) remarkable: hematoma range shorter more than 50% after 2d, skin silt color purple is obviously thin out, scleroma deliquescing, and local pressing is without tenderness, and blood vessel elasticity recovers, tremulous pulse place blood flow >=200mL during dialysis, and vein blood vessel pressure is normal; Take a turn for the better: hematoma range shorter more than 30% after 2d, subcutaneous silt color purple is obviously thin out, scleroma deliquescing around.Local tenderness obviously alleviates, and blood vessel elasticity is better; General: hematoma range shorter more than 30% after 4d, subcutaneous silt color purple is thin out, and scleroma is reduced.Local still has tenderness, vein blood vessel pressure >=100mmHg during dialysis.(2) classification is carried out to pain degree, 0 grade: without pain according to Canadian Mcjill pain scale (VRS-5); L level: mild pain, can stand, and can sleep orthobiosis; 2 grades: moderate pain, can stand, slightly disturb sleep; 3 grades: severe pain, interference sleep; 4 grades: have an intense pain, interference sleep is heavier, with other symptoms; 5 grades: pain cannot be stood, severe jamming is slept, with other symptoms or positive position.

1.4 statistical method

Application SPSS13.0 statistics software is to data analysis, and enumeration data adopts χ ²inspection, P < 0.05 has statistical significance for difference.

2 results

2.1 liang of group Clinical efficacy comparisons are in Table.Two groups are compared: < 5cm, and group asks comparing difference not statistically significant (P > 0.05); 5 ~ 10cm, group asks that comparing difference has statistical significance (P < is O.05); > 10cm, between group, comparing difference has statistical significance (P < 0.05).Seminar's ecchymosis scope, skin silt color purple and scleroma are disappeared soon, blood vessel elasticity recovers good, and blood flow is stablized, and can reach (200-250) mL/min: matched group ecchymosis expanses of skin silt color purple and scleroma regression time long, the pain sensation is obvious, and blood vessel elasticity recovers.

2.2 liang of group 48h, 72h pain degrees compare

In table 2.There is 48h, 72h pain degree and compare in hematoma, seminar's Pain Grading is all lower than matched group, and difference has statistical significance (P < 0.01).

Claims (3)

1. treat a pharmaceutical composition for internal arteriovenous fistula hematoma, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.

2. the pharmaceutical composition for the treatment of treatment internal arteriovenous fistula hematoma according to claim 2, is characterized in that, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.

3. the pharmaceutical composition for the treatment of treatment internal arteriovenous fistula hematoma according to claim 2, is characterized in that, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.