CN105497375A - Medicine composition for treating doxorubicin caused phlebitis - Google Patents

Medicine composition for treating doxorubicin caused phlebitis Download PDF

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CN105497375A
CN105497375A CN201510948855.1A CN201510948855A CN105497375A CN 105497375 A CN105497375 A CN 105497375A CN 201510948855 A CN201510948855 A CN 201510948855A CN 105497375 A CN105497375 A CN 105497375A
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herba
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刘燕
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Jinan Xinshidai Medicine Science and Technology Co Ltd
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Jinan Xinshidai Medicine Science and Technology Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit

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Abstract

The invention belongs to the technical field of medicine and particularly relates to a medicine composition for treating doxorubicin caused phlebitis. The medicine composition is prepared from, by weight, 4-6 parts of Chinese fan palm seeds, 4-6 parts of herba lysionti, 4-6 parts of herba pimpinellae, 4-6 parts of pentasachme caudatum, 4-6 parts of arisaema bockii, 4-6 parts of Abacopteris multilineata(Wall.) Ching, 4-6 parts of water mint, 4-6 parts of the root of perny germander, 4-6 parts of polygonum plebeium and 4-6 parts of coreopsis lanceolata. All the medicine is combined for use to achieve the effects of clearing away heat and toxic materials, promoting blood circulation to remove meridian obstruction, dispersing blood stasis and removing stasis, and relieving swelling and pain. The medicine composition has the advantages of being high in cure rate and total effective rate when used for treating doxorubicin leakage caused phlebitis.

Description

One is treated doxorubicin and is caused phlebitic pharmaceutical composition
Technical field
The invention belongs to medical art, be specifically related to one and treat doxorubicin and cause phlebitic pharmaceutical composition.
Background technology
Phlebitis is in the process of transfusion, due to input high concentration, hypertonicity, virose medicine and a kind of infusion reaction of causing. also can because of infusion set, dosing misoperation, repeated localised puncture and causing.
Doxorubicin (ADR) Shi Cong ring race antibiotics, because of fat-soluble anthracene nucleus aglucon existing in its structure, it containing soft brown sugar amine, basic amine group and acidic phenol hydroxyl, is that a kind of water solublity is strong simultaneously. and be nonspecific a kind of anticancer chemotherapeutic agent, all there is effect to each phase cell. simultaneouslyThere is good therapeutic effect to lymphoma, breast carcinoma, soft tissue neoplasms, also have certain curative effect to some tumor of multitube myeloma, head and neck cancer, genitourinary system and digestive system.Patient, because of self-condition and external condition impact, can not select subclavian vein, periphery PICC Puncture tubation etc., and use arm Superficial veins, often easily cause chemotherapeutic phlebitis, incidence rate about 84%.Both cause misery to patient, also have impact on the carrying out for the treatment of.
Summary of the invention
Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides one to treat doxorubicin and cause phlebitic pharmaceutical composition.
The present invention is achieved through the following technical solutions:
One is treated doxorubicin and is caused phlebitic pharmaceutical composition, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.
Preferably, above-mentioned treatment doxorubicin causes phlebitic pharmaceutical composition, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.
Preferred, above-mentioned treatment doxorubicin causes phlebitic pharmaceutical composition, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.
The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.
The indication of medicine of the present invention: be used for the treatment of doxorubicin and cause phlebitis.
The method of preparation and use of medicine of the present invention: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.
The standard of fine powder is on the books in Chinese Pharmacopoeia 2010 editions 1 annex.
The taboo item of medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.
In medicine of the present invention,
Chinese fanpalm seed another name seed of Livistona chinensis R.Br. is babassu Semen livistonae chinensis Livistonachinensis(Jacq.) seed of R.Br..Sweet in the mouth; Bitter; Property is put down.Function blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.
The black black bone of Herba Lysionoti Pauciflori another name, Radix Loxostigmatis griffithii, Lysionotus pauciflorus Maxim., little Herba Lycopi, Herba Lysionoti carnosae, rock tea, Herba Ophiorrhizae japonicae, rock orchid, Ba Yancao, the red grass of lung, Semen Benincasae grass, Parmelia saxatilis Ach., puerperal tea, Eupatorium formosanum Hayata., stone Radix Notoginseng, Shi Hu, Cicerbita azurea (Ledeb.) Beavuerd, Radix Loxostigmatis griffithii, stone Fructus Myricae rubrae, rock head Radix Notoginseng, rock strip, bamboo do not sting, member orchid, pattern rake.For the herb of Gesneriaceae Herba Lysionoti Pauciflori LysionotuspauciflorusMaxim..Bitter in the mouth; Pungent; Property is put down.Function wind dehumidifies; Preventing phlegm from forming and stopping coughing; Blood stasis dispelling stimulates the menstrual flow.Main air pain of dampness syndrome; Cough with asthma abundant expectoration; Menoxenia; Dysmenorrhea; Traumatic injury.
That Radix Pimpinellae Candolleanae another name Rhizoma valerianae latifoliae, mountain Radix Angelicae Sinensis, Horse hoof Radix Saposhnikoviae, JIUYUE Pemisetum flaccidum Griseb, all over the body string, tripodia Cicadae, Pemisetum flaccidum Griseb, Yangshan are smelly, Rhizoma typhonii divaricati, clearly Radix Angelicae Sinensis, sheep are had a strong smell is smelly, Herba Calthae, Fructus Piperis, lamb have a strong smell, Radix Pimpinellae Candolleanae, nine Ns dry, sheep mountain is smelly, Great Cold medicine, grass of cooling down, rabbit ear Radix Saposhnikoviae, little hero, little Flos Chrysanthemi, be root or the herb of samphire Folium Pruni Pimpinella anisum Linn. PimpinellacandolleanaWighy day Arn.Acrid in the mouth; Micro-hardship; Warm in nature.Return lung; Spleen; Stomach; Liver Channel.Function warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling.The cold pain of main gastral cavity abdomen; Dyspepsia; Dysentery; Flu; Cough; Infantile convulsion; Leucorrhea; Hernia; The testis swelling and hanging down of either of the testes; Scrofula; Treating swelling and pain by traumatic injury; Carbuncle sore tumefacting virus; Venom.
Radix Pentasacmi championii another name five, southern stone Herba seu Radix Metaplexis hemsleyanae, false fourth Diao Zhu, Herba Pteridis Multifidae, full grass, Radix Homonoiae Ripariae, be the herb of dicotyledon medicine asclepiadaceae stone Herba seu Radix Metaplexis hemsleyanae PendasacmechampioniiBenth..Bitter in the mouth; Micro-pungent; Cool in nature.Return liver; Gallbladder meridian.Function is fallen apart wind heat clearing away; Removing toxic substances and promoting subsidence of swelling.Main anemopyretic cold; Cough; Pharyngalgia; Conjunctival congestion; Hepatitis; Venom.
Rhizoma Arisaemati another name LUBIANHUANG, Serpentis Semen Maydis, old Serpentis Semen Maydis are the tuber of aroid Rhizoma Arisaemati ArisaemasikokianumFuanch. day or full edge Rhizoma Arisaemati Sav.var.s day tatum (Makino) Hand.-Mazz [A.sazensoovar.serratumMakino] 2.ArisaemasikokianumFranch. day Sav..Bitter in the mouth, pungent; Warm in nature.Return lung; Liver Channel.Function drying dampness to eliminate phlegm; Relieving spasm by subduing liver-wind; Reducing swelling and alleviating pain.Main productive cough due to phlegm-damp; Dizziness due to wind-phlegm; Epilepsy; Apoplexy; Facial hemiparalysis; Tetanus; Carbuncle; Venom.
Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching calls large plumage crescent Herba pteridii latiusculi, Coniogramme japonica (Thunb.) Diels, derives from fern Athyriaceae Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching Abacopterismultilineata(Wall.) Ching, is used as medicine with root stock.Bitter in the mouth, cold in nature.Function dredge the meridian passage, dampness removing of regulating the flow of vital energy.Cure mainly impairment caused by overstrain, peratodynia, dysentery, menoxenia.
Herba Limnophilae rugosae another name Tian Gencao, water mint, Rhizoma begoniae pedatifidae, water Herba Schizonepetae, ripples perfume, wrinkle leaf Herba Limnophilae sessiliflorae are the herb of goatweed Limnophila rugosa NitellaexpansaAllen, Limnophilarugosa (Roth) Merr..Acrid in the mouth; Sweet; Warm in nature.Return lung; Spleen; Stomach warp.Function invigorating spleen to remove dampness; Activating QI to eliminate phlegm.Main edema; Stomachache; Distension and fullness of the chest and abdomen; Cough; Children's's infantile dyspepsia; Furuncle.
Radix Teucrii Pernyi another name Mount Lushan spice, derives from Labiatae and spends Phryganeajaponica Ml. TeucriumpernyiFranch. in vain, be used as medicine with root.Taste is micro-sweet, warm in nature.Function invigorating spleen to remove dampness, removing toxic substances.Cure mainly dysentery.
Herba lespedezae pilosae another name Herba cassiae torae, derives from pulse family Lespedeza plant Herba lespedezae pilosae Lespedezapilosa(Thunb.) Sieb. day Zucc., is used as medicine with root and Herb.Bitter in the mouth, pungent, property is put down.Function heat clearing away eliminating stagnation, promoting blood circulation and stopping pain, line water detumescence.For lymphoid tuberculosis, cold abscess, deficiency-heat is not moved back, edema, waist hamstring osteodynia; Mastitis are controlled in external.
Folium Coreopsis lanceolatae another name Coreopsis lanceolata, sword-like leave coreopsis, derive from Compositae Folium Coreopsis lanceolatae CoreopsislanceolataL., with all herbal medicine.Acrid in the mouth, property is put down.Function blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.Cure mainly knife injury, innominate toxic swelling.
In medicine of the present invention, Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; Herba Lysionoti Pauciflori heat clearing and damp drying, reducing swelling and alleviating pain; Radix Pimpinellae Candolleanae promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling; Radix Pentasacmi championii falls apart wind heat clearing away, removing toxic substances and promoting subsidence of swelling; Rhizoma Arisaemati drying dampness to eliminate phlegm, reducing swelling and alleviating pain; Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching dredge the meridian passage, regulating QI to expel dampness; Herba Limnophilae rugosae, Radix Teucrii Pernyi invigorating spleen to remove dampness, activating QI to eliminate phlegm; Herba lespedezae pilosae heat clearing away eliminating stagnation, promoting blood circulation and stopping pain; Folium Coreopsis lanceolatae blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.All medicines share, and play heat-clearing and toxic substances removing altogether, promoting blood circulation to remove obstruction in the collateral, blood stasis-eliminating and stagnation-dissipating, the effect of reducing swelling and alleviating pain.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
One is treated doxorubicin and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:
Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 60g.
Method of preparation and use: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.
Embodiment 2
One is treated doxorubicin and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:
Chinese fanpalm seed 50g, Herba Lysionoti Pauciflori 70g, Radix Pimpinellae Candolleanae 50g, Radix Pentasacmi championii 70g, Rhizoma Arisaemati 50g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 70g, Herba Limnophilae rugosae 50g, Radix Teucrii Pernyi 70g, Herba lespedezae pilosae 50g, Folium Coreopsis lanceolatae 70g.
Method of preparation and use is with embodiment 1.
Embodiment 3
One is treated doxorubicin and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:
Chinese fanpalm seed 70g, Herba Lysionoti Pauciflori 50g, Radix Pimpinellae Candolleanae 70g, Radix Pentasacmi championii 50g, Rhizoma Arisaemati 70g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 50g, Herba Limnophilae rugosae 70g, Radix Teucrii Pernyi 50g, Herba lespedezae pilosae 70g, Folium Coreopsis lanceolatae 50g.
Method of preparation and use is with embodiment 1.
Embodiment 4
One is treated doxorubicin and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:
Chinese fanpalm seed 40g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 40g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 40g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 40g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 40g, Folium Coreopsis lanceolatae 60g.
Method of preparation and use is with embodiment 1.
Embodiment 5
One is treated doxorubicin and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:
Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 40g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 40g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 40g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 40g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 40g.
Method of preparation and use is with embodiment 1.
Carried out clinical pharrnacokinetics test to medicine of the present invention, Details as Follows:
1 data and method
1.1 physical data
Patient 80 example of selective gist doxorubicin generation chemotherapeutic phlebitis.Wherein man 48 example, female 32 example, the age at 28 ~ 75 years old, 56.4 years old mean age; I level phlebitis 24 example, II grade of phlebitis 12 example, III grade of phlebitis 4 example, all accepts a doxorubicin chemotherapy 1-6 course for the treatment of.Two groups are divided at random according to phlebitis category level.After transfusion terminates, except point of puncture, observation group adds Mel with the pharmaceutical composition fine powder 20g of the embodiment of the present invention 1 and is adjusted to pasty state, evenly embrocates (length is about 8cm, and width is about 5cm) along vein trend, then covers with gauze, and every day for several times; The external application of matched group 50% magnesium sulfate, in puncture place about 8cm blood vessel surface and surrounding skin external application, 4 ~ 6 times/d, 1h/ time, carries out controlled trial.
1.2 phlebitic diagnostic criterias
1.2.1 first skin rubefaction area takes puncture patient local skin to judge whether patient suffers from phlebitis.Its main contents are: after patient skin puncture, namely its skin rubefaction area score 3 points of persons judge to suffer from phlebitis.Centered by the point of puncture selected, having no skin rubefaction is 0 point; Diameter <3cm is 1 point; Diameter >=3cm is 2 points.
1.2.2 whether symptom and boundary phlebitis patient have pain or touch intravenous with or without the sense of bar rope, and be 1 point, no is 0 point.Whether local skin has red or swollen symptom, and rubescent or swelling is scored respectively, and diameter >2cm is 2 points, and diameter≤2cm is 1 point, and no is 0 point.
1.3 phlebitic criterion
I level: puncture has a pain, and red or swollen, vein, without streak change, does not touch scleroma; II grade: puncture has a pain, and red or swollen, vein has streak change, does not touch scleroma; III grade: puncture has a pain, and red or swollen, vein has streak change, can touch scleroma.During patient's quiet epirubicin, note patient fluid infusion's speed, observe local and exosmose with or without medicinal liquid, vein is with or without streak change, and patient is with or without pain etc. in inquiry.
1.4 inclusion criteria
Inclusion criteria is the controlled clinical trial meeting following condition: 1. to pharmaceutical composition of the present invention and magnesium sulfate not allergy sufferers.2. research design is the controlled clinical trial dividing equally grouping according to phlebitis category level at random.3. medicinal liquid is without local extravasation.4. suppurate or ulceration without skin infection.5. effect assessment is effective, effectively, invalid.Effective: after treatment 3d, local is red and swollen disappears, and move towards red line along vein and shoal, pain disappears, vein elastic return; Effective: treatment 5-7d local is red and swollen to disappear, pain relief; Invalid: treatment 7d phlebitis has no improvement.6. object of study ordinary circumstance (age, sex, disease) comparing difference not statistically significant (P>0.05).
1.5 statistical method
All data acquisition SPSS17.0 software analysis, enumeration data adopts χ 2inspection, phlebitis size scale comparatively adopts rank test, and measurement data application t checks.
2 results the results are shown in Table 1.
The comparison [n (%)] of table 1 liang group phlebitis Cure
Group n Cure (%) Effectively (%) Invalid (%) Total effective rate (%)
Observation group 40 21（52.5）** 19（47.5） 0（0） 100.0*
Matched group 40 7（17.5） 24（60.0） 9（22.5） 77.5
Compared with matched group, * P<0.05.
Two groups of phlebitis comparisons that a situation arises. observation group compares with matched group: difference has statistical significance (P<0.05).

Claims (3)

1. treat doxorubicin and cause a phlebitic pharmaceutical composition, be made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.
2. treatment doxorubicin according to claim 2 causes phlebitic pharmaceutical composition, it is characterized in that, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.
3. treatment doxorubicin according to claim 2 causes phlebitic pharmaceutical composition, it is characterized in that, is made up of the Chinese medicine of following weight portion:
Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.
CN201510948855.1A 2015-12-18 2015-12-18 Medicine composition for treating doxorubicin caused phlebitis Withdrawn CN105497375A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007070336A (en) * 2005-08-12 2007-03-22 Takehito Kono Hair growing substance
CN103463495A (en) * 2013-09-23 2013-12-25 陈军 Drug for treating senile postoperative acute mental disorders
CN103463496A (en) * 2013-09-23 2013-12-25 祝爱莲 Drug for treating ankylosing spondylitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007070336A (en) * 2005-08-12 2007-03-22 Takehito Kono Hair growing substance
CN103463495A (en) * 2013-09-23 2013-12-25 陈军 Drug for treating senile postoperative acute mental disorders
CN103463496A (en) * 2013-09-23 2013-12-25 祝爱莲 Drug for treating ankylosing spondylitis

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