CN105456570A - Medicine composition for treating hyperplasia of mammary glands and preparation method thereof - Google Patents
Medicine composition for treating hyperplasia of mammary glands and preparation method thereof Download PDFInfo
- Publication number
- CN105456570A CN105456570A CN201610063625.1A CN201610063625A CN105456570A CN 105456570 A CN105456570 A CN 105456570A CN 201610063625 A CN201610063625 A CN 201610063625A CN 105456570 A CN105456570 A CN 105456570A
- Authority
- CN
- China
- Prior art keywords
- folium
- pharmaceutical composition
- parts
- chinese medicine
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Insects & Arthropods (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine composition for treating the hyperplasia of mammary glands and a preparation method thereof. The medicine composition is prepared from 20-30 parts of traditional Chinese medicine preparation, 5-10 parts of folium ginkgo extract, 1-5 parts of chondroitin sulfate, 0.1-0.3 parts of pterostilbene and 0.1-1 part of diosmetin. The traditional Chinese medicine preparation is prepared from folium cycas, Japanese ardisia, dysosma versipellis, fiveleaf akebia fruit, pseudo-ginseng, piper wallichii, purple perilla and scorpions according to the weight ratio of (3-5):(2-6):(2-5):(1-3):(1-3):(3-5):(1-2):(0.1-0.5) through decocting, filtering and concentrating. The medicine composition has functions of promoting blood circulation to remove blood stasis, stimulating menstrual flow to remove stasis, dredging channels by soothing liver, dredging latex vessels, promoting qi circulation to relieve pain, expelling wind and relieving muscular spasm, clearing away heat to remove blood stasis and the like, and has an excellent effect on treating the hyperplasia of mammary glands.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, be specifically related to a kind of pharmaceutical composition for the treatment of cyclomastopathy and preparation method thereof, belong to technical field of medicine.
Background technology
Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue, is the modal cystic hyperplasia of breast of women.The reason that cyclomastopathy occurs mainly estrogen definitely or relatively increases, and the bad Nervous and Mental Factors such as spiritual hypertonicity or emotion be too exciting.Cyclomastopathy is women of child-bearing age's commonly encountered diseases and frequently-occurring disease, accounts for breast disease 75%, wherein has the patient of 2%-5% that canceration occurs.Cyclomastopathy belongs to Chinese medicine " nodules of the breast " category, and think that Chong and Ren channel disorder is the basic reason that cyclomastopathy occurs, its pathogenesis mostly is caused by depression of liver-QI, stagnation of QI blood stasis, hyperactive liver-QI attacking the spleen, the dysfunction of the spleen, stagnation of Qi and phelgm etc.Clinically there are distending pain of the breast, pain, caking etc., except above-mentioned symptom, mainly in lobule and tip conduit performance epithelial hyperplasia and acinus expansion and hypertrophy.Its key is E2, P off-leveling in hypothalamic-pituitary-ovary gonad axis endocrine disturbance and body.Galactophore epithelial cell and interstitial cell hyperplasia after long term, PRL increases, and increases the storage of connective tissue water sodium and stays, cause edema between lobule.
Adopt operation or hormone and receptor blocking agent etc. to this disease more at present, though effective in cure, hormone metabolism often can be caused to be more afterwards tending towards disorderly.Some oral medicine then effect is obvious not, and treatment time is long, and onset is slow.Therefore, be necessary to provide a kind of pharmaceutical composition for the treatment of cyclomastopathy, can drug side effect be reduced while raising drug effect.
Summary of the invention
Technical problem to be solved by this invention is for the deficiencies in the prior art, and provides a kind of pharmaceutical composition for the treatment of cyclomastopathy, and curative effect is fast, have no side effect; Depressed liver-energy dispersing and QI regulating, removing obstruction in the collateral to relieve pain, also have certain opsonic action to liver, stomach in addition.
To achieve these goals, the present invention adopts following technical scheme:
Treat a pharmaceutical composition for cyclomastopathy, comprise 20 ~ 30 parts of Chinese medicine preparation, 5 ~ 10 parts of Folium Ginkgo extract, 1 ~ 5 part of chondroitin sulfate, 0.1 ~ 0.3 portion of pterostilbene, 0.1 ~ 1 part of diosmetin.
Preferably, the pharmaceutical composition of described treatment cyclomastopathy, comprises 25 parts of Chinese medicine preparation, 7 parts of Folium Ginkgo extract, 3 parts of chondroitin sulfate, 0.2 portion of pterostilbene, 0.6 part of diosmetin.
Preferably, the pharmaceutical composition of described treatment cyclomastopathy, comprises 25 parts of Chinese medicine preparation, 8 parts of Folium Ginkgo extract, 2 parts of chondroitin sulfate, 0.2 portion of pterostilbene, 0.4 part of diosmetin.
Preferably, described Chinese medicine preparation, is prepared from through decocting, filtering and concentrate according to the weight ratio of 3 ~ 5:2 ~ 6:2 ~ 5:1 ~ 3:1 ~ 3:3 ~ 5:1 ~ 2:0.1 ~ 0.5 by Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio.
Preferably, the weight ratio of described Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio is preferably 4:3:3:1:1:4:1:0.3.
The pharmaceutical composition for the treatment of cyclomastopathy of the present invention is prepared from by following method:
(1) pretreatment of raw material: raw material of Chinese medicine Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio are removed impurity and part of going mouldy, cleans, dry, be broken into the fragment that length is 3 ~ 5cm respectively;
(2) decoct, filter: pretreated raw material in step (1), according to described ratio mix homogeneously, is then added the pure water of 55 ~ 75 times of weight, decocts 4 ~ 6 times, each 15 ~ 25min; Respectively coarse filtration carried out to above-mentioned each decoction liquor, filters step by step, remove floating foreign material and leave and take filtrate and obtain coarse filtration liquid; Merge coarse filtration liquid and carry out fine filtering, successively by the microporous filter membrane of different pore size, operating pressure 0.2-3MPa, obtains fine filtering liquid;
(3) concentrated: fine filtering liquid step (2) prepared merges, and mixed liquor concentrates in concentrating under reduced pressure tank, and concentrated solution is described Chinese medicine preparation;
(4) pelletize: the Folium Ginkgo extract of described ratio, chondroitin sulfate, pterostilbene, diosmetin are added in the Chinese medicine preparation that step (3) obtains, obtain powder by Freeze Drying Technique, this powder is the pharmaceutical composition of described treatment cyclomastopathy.
Preferably, in step 2, described be filtered into step by step employing 100 order, 200 orders, 300 orders and 400 mesh sieve thin,tough silk successively filter.
Preferably, in step 2, described is that, first by the microporous filter membrane of 0.45 μm, operating pressure is 0.3MPa successively by the microporous filter membrane of different pore size, and then by the microporous filter membrane of 0.22 μm, operating pressure 0.2MPa, obtains fine filtering liquid.
Preferably, in step 3, described mixed liquor is concentrated in concentrating under reduced pressure tank, and being concentrated into relative density is 1 ± 0.01.
Medicine composition dosage form of the present invention is capsule, 20-35mg/ capsules, and instructions of taking is oral, every day three times, takes before the meal respectively at early, middle and late, preferably takes within 0.5 ~ 1h before the meal, each serving with 1 ~ 2.
Folium cordylines fruticosae of the present invention is the leaf of Agavaceae plant ti, property slightly sweet flavor, cool; Function cures mainly: heat clearing away, hemostasis, dissipating blood stasis; Control dysentery, spit blood, have blood in stool, hematuria, stomachache, menorrhagia, treating swelling and pain by traumatic injury.
PINGDIMU of the present invention is the Herb of Myrsinacea plant Herba Ardisiae Japonicae, and property is put down, acrid in the mouth, micro-hardship; Return lung, Liver Channel; Function cures mainly: new chronic cough is coughed, sputum mixed with blood, jaundice, edema, stranguria, leucorrhea, amenorrhea stimulate the menstrual flow, rheumatic arthralgia, traumatic injury, painful and swollen testis.
Radix et Rhizoma Dysosmatis of the present invention is Jin Kuilian again, Latin literary fame DysosmaversipellisM.ChengexYing; Belong to Berberidaceae, the white platymiscium of ghost; Function cures mainly: heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, removing blood stasis to reduce swelling; Control carbuncle, furuncle, scrofula, throat moth, traumatic injury, venom.
Fructus Akebiae of the present invention is the fruit of Akebia plants of Lardizabalaceae Caulis Akebiae; Property bitter, flat; Return liver, stomach warp; Effect: depressed liver-energy dispersing and QI regulating, eliminating stagnation.
Radix Notoginseng of the present invention, medicinal part is the dry root welding technology of plant, sweet, the micro-hardship of property, temperature; Return liver, stomach warp, there is the effect of dispersing hemostasis, subduing swelling and relieving pain.
Caulis et Folium piperis of the present invention, the dry branch and leaf of Piperaceae Zhi Wu Mao Betel Piperpuberulum (Benth.) Maxim., pungent, warm, return liver, spleen channel; Wind-damp dispelling, relaxing muscles and tendons network, strong waist knee joint, except arthralgia pain; For anemofrigid-damp arthralgia, bones and muscles pain.Weakness of the waist and knees, cough and asthma, cough of suffering from a deficiency of the kidney, sexual impotence.
Folium Perillae of the present invention, Perillafrutescens (L.) Britt., another name: osmanthus is weak, common perilla, red Soviet Union etc.; Perilla medical herbs, has the function of the cold expelling that induces sweat, relieving QI stagnancy in the stomach, cures mainly anemofrigid cold, cough, distension and fullness of the chest and abdomen, the diseases such as nausea and vomiting; Seed also claims Fructus Perillae, has the function of antitussive and antiasthmatic, society's expectorant.
Scorpio of the present invention, property is pungent, flat, returns Liver Channel, has endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation function, for liver-wind stirring up internally, spasm tic, infantile convulsion, middle air port
, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Folium Ginkgo extract of the present invention; for the dried leaves extract of Ginkgoaceae plant Ginkgo biloba GinkgobilobaL.; for light yellowish brown flowable powder, antiotasis, antagonism platelet activating factor PAF can be regulated, suppress platelet aggregation, reduce blood viscosity, increase ischemia internal organs blood flow, improve microcirculation and lectin from hemolymph, scavenging free radicals, the infringement alleviating harmful substance, neuroprotective cell.Commercially available prod, can buy.
Chondroitin sulfate of the present invention, is the covalently bound class glycosaminoglycans forming Dan Baiduotang proteoglycan PG on protein, has pain relieving, promotes regenerating bone or cartilage, improves blood circulation, accelerates the effects such as metabolism.
Pterostilbene of the present invention, Chinese another name 3,5-dimethoxy-4 ' '-hydroxy stibene, molecular formula C
16h
16o
3, there is abundant pharmacy value: the effect with antioxidation, anti-self-destruction propagation, blood fat reducing, suppression COX-1 and COX-2, anticancer and antifungal is commercially available prod.
Diosmetin (C of the present invention
16h
12o
6), be a kind of natural flavone compounds suppressing people CYP1A enzyme activity, from the peel of Fructus Citri Limoniae; Having antioxidation, infection, shock, antimutagenic and resistance and should wait effect, is commercially available prod.
The advantage of technical solution of the present invention is, many effects such as the Chinese medicine composition of invention has blood circulation promoting and blood stasis dispelling, eliminating stagnation of stimulating the menstrual flow, dispersing the stagnated liver-QI and dredging collateral, dredging latex dust, promoting the circulation of QI to relieve pain, endogenous wind stopping spasmolytic, heat clearing away dissipating blood stasis, have fabulous therapeutical effect to cyclomastopathy.
Detailed description of the invention
Below the detailed description of the invention of technical solution of the present invention is described in detail, but the present invention is not limited to following description content:
Embodiment 1:
Treat a pharmaceutical composition for cyclomastopathy, be prepared from by following method:
(1) pretreatment of raw material: raw material of Chinese medicine Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio are removed impurity and part of going mouldy, cleans, dry, be broken into the fragment that length is 3 ~ 5cm respectively;
(2) decoct, filter: the ratio mix homogeneously by Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio after pretreatment in step (1) according to weight ratio being 4:3:3:1:1:4:1:0.3, then the pure water of 60 times of weight is added, decoct 5 times, each 20min; Respectively coarse filtration is carried out to above-mentioned each decoction liquor, filter the floating foreign material of (adopting 100 orders, 200 orders, 300 orders and 400 mesh sieve thin,tough silk successively to filter) removal step by step and leave and take filtrate acquisition coarse filtration liquid, merge coarse filtration liquid and carry out fine filtering, first by the microporous filter membrane of 0.45 μm, operating pressure is 0.3MPa, then by the microporous filter membrane of 0.22 μm, operating pressure 0.2MPa, obtains fine filtering liquid;
(3) concentrated: fine filtering liquid step (2) prepared merges, and mixed liquor concentrates in concentrating under reduced pressure tank, and being concentrated into relative density is 1 ± 0.01, and concentrated solution is described Chinese medicine preparation;
(4) pelletize: the Folium Ginkgo extract of 7 weight portions, 3 parts sulfuric acid chrondroitins, 0.2 weight portion pterostilbene, 0.6 weight portion diosmetin are added in 25 weight portion Chinese medicine preparation prepared by step (3), obtain powder by Freeze Drying Technique after stirring, this powder is the pharmaceutical composition of described treatment cyclomastopathy.
This pharmaceutical composition is prepared into capsule, 30mg/ capsules after adding customary adjuvant.
Embodiment 2:
Treat a pharmaceutical composition for cyclomastopathy, be prepared from by following method:
(1) pretreatment of raw material: raw material of Chinese medicine Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio are removed impurity and part of going mouldy, cleans, dry, be broken into the fragment that length is 3 ~ 5cm respectively;
(2) decoct, filter: the ratio mix homogeneously by Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio after pretreatment in step (1) according to weight ratio being 4:3:3:1:1:4:1:0.3, then the pure water of 60 times of weight is added, decoct 5 times, each 20min; Respectively coarse filtration is carried out to above-mentioned each decoction liquor, filter the floating foreign material of (adopting 100 orders, 200 orders, 300 orders and 400 mesh sieve thin,tough silk successively to filter) removal step by step and leave and take filtrate acquisition coarse filtration liquid, merge coarse filtration liquid and carry out fine filtering, first by the microporous filter membrane of 0.45 μm, operating pressure is 0.3MPa, then by the microporous filter membrane of 0.22 μm, operating pressure 0.2MPa, obtains fine filtering liquid;
(3) concentrated: fine filtering liquid step (2) prepared merges, and mixed liquor concentrates in concentrating under reduced pressure tank, and being concentrated into relative density is 1 ± 0.01, and concentrated solution is described Chinese medicine preparation;
(4) pelletize: the Folium Ginkgo extract of 8 weight portions, 2 parts sulfuric acid chrondroitins, 0.2 weight portion pterostilbene, 0.4 weight portion diosmetin are added in 25 weight portion Chinese medicine preparation prepared by step (3), obtain powder by Freeze Drying Technique after stirring, this powder is the pharmaceutical composition of described treatment cyclomastopathy.
This pharmaceutical composition is prepared into capsule, 30mg/ capsules after adding customary adjuvant.
Embodiment 3:
Treat a pharmaceutical composition for cyclomastopathy, be prepared from by following method:
(1) pretreatment of raw material: raw material of Chinese medicine Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio are removed impurity and part of going mouldy, cleans, dry, be broken into the fragment that length is 3 ~ 5cm respectively;
(2) decoct, filter: the ratio mix homogeneously by Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio after pretreatment in step (1) according to weight ratio being 4:5:5:3:1:3:2:0.1, then the pure water of 60 times of weight is added, decoct 5 times, each 20min; Respectively coarse filtration is carried out to above-mentioned each decoction liquor, filter the floating foreign material of (adopting 100 orders, 200 orders, 300 orders and 400 mesh sieve thin,tough silk successively to filter) removal step by step and leave and take filtrate acquisition coarse filtration liquid, merge coarse filtration liquid and carry out fine filtering, first by the microporous filter membrane of 0.45 μm, operating pressure is 0.3MPa, then by the microporous filter membrane of 0.22 μm, operating pressure 0.2MPa, obtains fine filtering liquid;
(3) concentrated: fine filtering liquid step (2) prepared merges, and mixed liquor concentrates in concentrating under reduced pressure tank, and being concentrated into relative density is 1 ± 0.01, and concentrated solution is described Chinese medicine preparation;
(4) pelletize: the Folium Ginkgo extract of 8 weight portions, 2 parts sulfuric acid chrondroitins, 0.2 weight portion pterostilbene, 0.4 weight portion diosmetin are added in 25 weight portion Chinese medicine preparation prepared by step (3), obtain powder by Freeze Drying Technique after stirring, this powder is the pharmaceutical composition of described treatment cyclomastopathy.
This pharmaceutical composition is prepared into capsule, 30mg/ capsules after adding customary adjuvant.
Comparative example 1:
Treat a pharmaceutical composition for cyclomastopathy, its component and preparation method substantially the same manner as Example 1, difference is, not containing the pterostilbene of described ratio, this pharmaceutical composition is labeled as drugs compared 1.
Comparative example 2:
Treat a pharmaceutical composition for cyclomastopathy, its component and preparation method substantially the same manner as Example 1, difference is, not containing the diosmetin of described ratio, this pharmaceutical composition is labeled as drugs compared 2.
Comparative example 3:
Treat a pharmaceutical composition for cyclomastopathy, its component and preparation method substantially the same manner as Example 1, difference is, not containing the pterostilbene of described ratio and diosmetin, this pharmaceutical composition is labeled as drugs compared 3.
Demonstration test one:
1, material:
1.1, test medicine:
Medicine prepared by the embodiment of the present invention 1, the medicine of comparative example 1 ~ 3 preparation and Western medicine BUPIXIAO PIAN; Add the medicinal liquid that distilled water is mixed with 0.2g/ml respectively.
1.2, animal:
Female unpregnancy Wistar rat 140, is divided into 7 groups at random, often organizes 20: embodiment 1 medication therapy groups, drugs compared 1 treatment group, drugs compared 2 treatment group, drugs compared 3 treatment group, BUPIXIAO PIAN treatment group, blank group and model control group.
2, test:
2.1 modelings: adopt exogenous estrogen long-time stimulus to set up cyclomastopathy pathology model, blank group intramuscular injection every day normal saline 0.2ml, all the other are the equal intramuscular injection estradiol benzoate (0.5mg/kg) of group respectively, 1 times/day, continuous 25 days, intramuscular injection Progesterone (4mg/kg) subsequently, one times/day, continuous 5 days, cause hyperplasia of mammary gland model.
2.2 administrations: after modeling success, blank group and model control group gavage give normal saline 10ml/kg, the corresponding medicinal liquid of each treatment group gavage, 10ml/kg, once a day, continuous 30 days, before grouping modeling, after modeling, after administration, measure second pair of height of nipples
3, result:
Table 1 different pharmaceutical on each group of rat second on the impact of height of nipples
As shown in Table 1, medicine of the present invention has the effect significantly reducing height of nipples.
Demonstration test two:
(1) drug administration: the medicine prepared with the embodiment of the present invention 1 and comparative example, and Western medicine is as the Chinese medicine for the treatment of cyclomastopathy, every day 3 times, each 8 grams 20 days is a course for the treatment of; Often organize 60 patients;
(2) criterion of therapeutical effect:
Effective: transference cure, lump in breast disappears or reduces more than 50%, and drug withdrawal is not recurred for 3 months;
Effective: clinical symptom disappearance, lump in breast reduces;
Invalid: mastalgia, lump does not reduce.
(3) shown by the treatment of a course for the treatment of to 300 cyclomastopathy patients, result is as shown in table 2:
Table 2: the clinical therapeutic efficacy of different pharmaceutical
| Group | n | Effective | Effectively | Invalid | Total effective rate 5--> |
| Embodiment 1 medication therapy groups | 60 | 57 | 1 | 2 | 96.7％ |
| Drugs compared 1 treatment group | 60 | 39 | 2 | 19 | 68.3％ |
| Drugs compared 2 treatment group | 60 | 40 | 3 | 20 | 66.7％ |
| Drugs compared 3 treatment group | 60 | 30 | 3 | 27 | 55％ |
| BUPIXIAO PIAN treatment group | 60 | 35 | 12 | 13 | 78.3％ |
Above-mentioned example just for technical conceive of the present invention and technical characterstic are described, can not limit the scope of the invention with this.The equivalent transformation that all essence according to the present invention is done or modification, all should be encompassed within protection scope of the present invention.
Claims (10)
1. treat a pharmaceutical composition for cyclomastopathy, it is characterized in that, comprise 20 ~ 30 parts of Chinese medicine preparation, 5 ~ 10 parts of Folium Ginkgo extract, 1 ~ 5 part of chondroitin sulfate, 0.1 ~ 0.3 portion of pterostilbene, 0.1 ~ 1 part of diosmetin.
2. pharmaceutical composition according to claim 1, is characterized in that, the pharmaceutical composition of described treatment cyclomastopathy, comprises 25 parts of Chinese medicine preparation, 7 parts of Folium Ginkgo extract, 3 parts of chondroitin sulfate, 0.2 portion of pterostilbene, 0.6 part of diosmetin.
3. pharmaceutical composition according to claim 1, is characterized in that, the pharmaceutical composition of described treatment cyclomastopathy, comprises 25 parts of Chinese medicine preparation, 8 parts of Folium Ginkgo extract, 2 parts of chondroitin sulfate, 0.2 portion of pterostilbene, 0.4 part of diosmetin.
4. pharmaceutical composition according to claim 1, it is characterized in that, described Chinese medicine preparation, is prepared from through decocting, filtering and concentrate according to the weight ratio of 3 ~ 5:2 ~ 6:2 ~ 5:1 ~ 3:1 ~ 3:3 ~ 5:1 ~ 2:0.1 ~ 0.5 by Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio.
5. pharmaceutical composition according to claim 4, is characterized in that, the weight ratio of described Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio is 4:3:3:1:1:4:1:0.3.
6. the preparation method of the pharmaceutical composition described in any one of Claims 1 to 5, is characterized in that, comprises the following steps:
(1) pretreatment of raw material: raw material of Chinese medicine Folium cordylines fruticosae, PINGDIMU, Radix et Rhizoma Dysosmatis, Fructus Akebiae, Radix Notoginseng, Caulis et Folium piperis, Folium Perillae, Scorpio are removed impurity and part of going mouldy, cleans, dry, be broken into the fragment that length is 3 ~ 5cm respectively;
(2) decoct, filter: pretreated raw material in step (1), according to described ratio mix homogeneously, is then added the pure water of 55 ~ 75 times of weight, decocts 4 ~ 6 times, each 15 ~ 25min; Respectively coarse filtration carried out to above-mentioned each decoction liquor, filters step by step, remove floating foreign material and leave and take filtrate and obtain coarse filtration liquid; Merge coarse filtration liquid and carry out fine filtering, successively by the microporous filter membrane of different pore size, operating pressure 0.2-3MPa, obtains fine filtering liquid;
(3) concentrated: fine filtering liquid step (2) prepared merges, and mixed liquor concentrates in concentrating under reduced pressure tank, and concentrated solution is described Chinese medicine preparation;
(4) pelletize: the Folium Ginkgo extract of described ratio, chondroitin sulfate, pterostilbene, diosmetin are added in the Chinese medicine preparation that step (3) obtains, obtain powder by Freeze Drying Technique, this powder is the pharmaceutical composition of described treatment cyclomastopathy.
7. method according to claim 6, is characterized in that, in step 2, described be filtered into step by step employing 100 order, 200 orders, 300 orders and 400 mesh sieve thin,tough silk successively filter.
8. method according to claim 6, is characterized in that, in step 2, described is that, first by the microporous filter membrane of 0.45 μm, operating pressure is 0.3MPa successively by the microporous filter membrane of different pore size, then by the microporous filter membrane of 0.22 μm, operating pressure 0.2MPa, obtains fine filtering liquid.
9. method according to claim 6, is characterized in that, in step 3, described mixed liquor is concentrated in concentrating under reduced pressure tank, and being concentrated into relative density is 1 ± 0.01.
10. the using method of the pharmaceutical composition described in any one of Claims 1 to 5, it is characterized in that, described medicine composition dosage form is capsule, 20-35mg/ capsules, instructions of taking is oral, every day three times, takes before the meal respectively at early, middle and late, take within 0.5 ~ 1h before the meal, each serving with 1 ~ 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610063625.1A CN105456570A (en) | 2016-01-28 | 2016-01-28 | Medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610063625.1A CN105456570A (en) | 2016-01-28 | 2016-01-28 | Medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105456570A true CN105456570A (en) | 2016-04-06 |
Family
ID=55595027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610063625.1A Pending CN105456570A (en) | 2016-01-28 | 2016-01-28 | Medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105456570A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748756A (en) * | 2016-04-26 | 2016-07-13 | 泸州岷宏科技有限公司 | Traditional Chinese medicine composition for preventing and treating mammary gland diseases and preparation method thereof |
| CN107551390A (en) * | 2017-08-21 | 2018-01-09 | 常熟佳禾生物科技有限公司 | It is a kind of to be used to treat Chinese medicine brassiere paster of hyperplasia of mammary glands and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908477A (en) * | 2012-10-31 | 2013-02-06 | 王义霞 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands |
| CN104940933A (en) * | 2015-06-15 | 2015-09-30 | 青岛大学附属医院 | Medicine used for preventing and treating cardiovascular disease |
-
2016
- 2016-01-28 CN CN201610063625.1A patent/CN105456570A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908477A (en) * | 2012-10-31 | 2013-02-06 | 王义霞 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands |
| CN104940933A (en) * | 2015-06-15 | 2015-09-30 | 青岛大学附属医院 | Medicine used for preventing and treating cardiovascular disease |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748756A (en) * | 2016-04-26 | 2016-07-13 | 泸州岷宏科技有限公司 | Traditional Chinese medicine composition for preventing and treating mammary gland diseases and preparation method thereof |
| CN107551390A (en) * | 2017-08-21 | 2018-01-09 | 常熟佳禾生物科技有限公司 | It is a kind of to be used to treat Chinese medicine brassiere paster of hyperplasia of mammary glands and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102058673B (en) | Chinese medicine composition for expelling wind and removing dampness and preparation method thereof | |
| CN104138550A (en) | Preparation method of medicine for treating peptic ulcers | |
| CN102078569B (en) | Traditional Chinese medicine preparation for treating liver cancer and preparation method thereof | |
| CN104288228A (en) | Traditional Chinese medicine composite for treating pain in neck, shoulders, waist and legs | |
| CN103432559A (en) | Traditional Chinese medicine composition for treating spanomenorrhea and dysmenorrhea caused by blood stasis and preparation method and application thereof | |
| CN105213974A (en) | One treats lymphadenomatous Chinese medicine composition and application thereof | |
| CN105456570A (en) | Medicine composition for treating hyperplasia of mammary glands and preparation method thereof | |
| CN105125677A (en) | Preparation method of preparation pill for treating primary trigeminal neuralgia | |
| CN104147388B (en) | Traditional Chinese medicine composition for treating migraine and preparation method thereof | |
| CN106362111A (en) | Pharmaceutical composition for improving phlegm-dampness constitution, medicine brick and preparation method of medicine brick | |
| CN104491718B (en) | Medicine for treating liver-depression and phlegm-stasis type mammary gland hyperplasia and preparation method | |
| CN104095944B (en) | A kind of Chinese medicine composition for the treatment of cyclomastopathy and preparation method thereof | |
| CN102935209A (en) | Traditional Chinese medicinal preparation for treating hyperplasia of mammary glands | |
| CN103301304A (en) | Traditional Chinese medicine composition used for treating hyperplasia of mammary glands | |
| CN102670885B (en) | Medicine for treating cough and asthma and preparation method thereof | |
| CN102145099A (en) | Traditional Chinese medicine for treating infertility caused by liver stagnation | |
| CN105412424A (en) | Pharmaceutical preparation containing argy wormwood leaves and having bowel relaxing function as well as preparation method of pharmaceutical preparation | |
| CN105169278A (en) | Dandelion oral liquid capable of protecting liver and benefiting gallbladder and preparation method thereof | |
| CN104338052A (en) | Formula of traditional Chinese medicine for treating cerebral thrombosis | |
| CN104225282A (en) | Traditional Chinese medicine for treating postpartum headache | |
| CN102940806B (en) | Chinese medicinal composition for treating hyperlipidemia | |
| CN110841007B (en) | Traditional Chinese medicine composition for treating cerebral apoplexy sequela and application thereof | |
| CN106038905A (en) | Narcotic analgesic and preparation method thereof | |
| CN105056160A (en) | Medicine composition for treating agalactia of cows and preparation method thereof | |
| CN105853712A (en) | Traditional Chinese medicine composition for treating ophthalmic diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160406 |