CN105412449A - Pharmaceutical composition for treating phlebitis caused by fat emulsion - Google Patents

Abstract

The invention belongs to the technical field of medicament, and particularly relates to a pharmaceutical composition for treating phlebitis caused by a fat emulsion. The pharmaceutical composition is prepared from the following traditional Chinese medicines in parts by weight: 4 to 6 parts of fructus livistonae, 4 to 6 parts of fewflower lysionotus herb, 4 to 6 parts of herba pimpinellae, 4 to 6 parts of pentasachme caudatum, 4 to 6 parts of arisaema bockii, 4 to 6 parts of nude pronephrium rhizome, 4 to 6 parts of all-grass of winkled marshweed, 4 to 6 parts of root of perny germander, 4 to 6 parts of lespedeza pilosa and 4 to 6 parts of coreopsis lanceolata. According to the pharmaceutical composition disclosed by the invention, all traditional Chinese medicines are in combined action, so that the common effects of clearing away heat and detoxifying, activating the blood circulation and dredging collaterals, dispersing blood stasis and eliminating stasis, and removing swelling and relieving the pain are achieved; the pharmaceutical composition has an obvious curative effect in treating phlebitis caused by leakage of the fat emulsion, and more satisfactory effects of pain relieving time, swelling eliminating time and damaged skin healing time are obtained.

Description

One is treated fat milk and is caused phlebitic pharmaceutical composition

Technical field

The invention belongs to medical art, be specifically related to one and treat fat milk and cause phlebitic pharmaceutical composition.

Background technology

Phlebitis is due to input stimulus solution, the plastic tube overlong time that solution concentration is higher or intravenous placement zest is stronger, causes local wall of vein chemical or mechanicalness nociceptive inputs.Its risk factor has the stimulation etc. of dripping speed, the caliber using puncture (conduit) pin, patient profiles, medicine itself of the PH of transfusion particle, solution, solution osmotic pressure, venous transfusion position, solution.

Fat milk is a kind of not only even but also stable lipomul be made up of Refined Soybean and refined lecithin, and wherein the fatty acid of 60% is essential fatty acid, can input, have heat high through peripheral vein, does not need insulin to participate in, without advantages such as hypertonicity diuresis.Fat milk is hypertonicity liquid again, after intravenous injection, large to vascular stimulation, and easily cause blood vessel hardening, elasticity reduces, and even occurs the phlebitis symptoms such as red, swollen, pain.The conventional magnesium sulfate diluent external application of tradition, though can play certain therapeutic effect, the alleviation of pain symptom, the absorption of edema are undesirable, and need remain that the area that exosmoses is moistening.Continuous replacing gauze, patient often adheres to disappearing completely less than swelling, thus extends healing time.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides one to treat fat milk and cause phlebitic pharmaceutical composition.

The present invention is achieved through the following technical solutions:

One is treated fat milk and is caused phlebitic pharmaceutical composition, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.

Preferably, above-mentioned treatment fat milk causes phlebitic pharmaceutical composition, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.

Preferred, above-mentioned treatment fat milk causes phlebitic pharmaceutical composition, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of medicine of the present invention: be used for the treatment of fat milk and cause phlebitis.

The method of preparation and use of medicine of the present invention: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.

The standard of fine powder is on the books in Chinese Pharmacopoeia 2010 editions 1 annex.

The taboo item of medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In medicine of the present invention,

Chinese fanpalm seed another name seed of Livistona chinensis R.Br. is babassu Semen livistonae chinensis Livistonachinensis(Jacq.) seed of R.Br..Sweet in the mouth; Bitter; Property is put down.Function blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.

The black black bone of Herba Lysionoti Pauciflori another name, Radix Loxostigmatis griffithii, Lysionotus pauciflorus Maxim., little Herba Lycopi, Herba Lysionoti carnosae, rock tea, Herba Ophiorrhizae japonicae, rock orchid, Ba Yancao, the red grass of lung, Semen Benincasae grass, Parmelia saxatilis Ach., puerperal tea, Eupatorium formosanum Hayata., stone Radix Notoginseng, Shi Hu, Cicerbita azurea (Ledeb.) Beavuerd, Radix Loxostigmatis griffithii, stone Fructus Myricae rubrae, rock head Radix Notoginseng, rock strip, bamboo do not sting, member orchid, pattern rake.For the herb of Gesneriaceae Herba Lysionoti Pauciflori LysionotuspauciflorusMaxim..Bitter in the mouth; Pungent; Property is put down.Function wind dehumidifies; Preventing phlegm from forming and stopping coughing; Blood stasis dispelling stimulates the menstrual flow.Main air pain of dampness syndrome; Cough with asthma abundant expectoration; Menoxenia; Dysmenorrhea; Traumatic injury.

That Radix Pimpinellae Candolleanae another name Rhizoma valerianae latifoliae, mountain Radix Angelicae Sinensis, Horse hoof Radix Saposhnikoviae, JIUYUE Pemisetum flaccidum Griseb, all over the body string, tripodia Cicadae, Pemisetum flaccidum Griseb, Yangshan are smelly, Rhizoma typhonii divaricati, clearly Radix Angelicae Sinensis, sheep are had a strong smell is smelly, Herba Calthae, Fructus Piperis, lamb have a strong smell, Radix Pimpinellae Candolleanae, nine Ns dry, sheep mountain is smelly, Great Cold medicine, grass of cooling down, rabbit ear Radix Saposhnikoviae, little hero, little Flos Chrysanthemi, be root or the herb of samphire Folium Pruni Pimpinella anisum Linn. PimpinellacandolleanaWighy day Arn.Acrid in the mouth; Micro-hardship; Warm in nature.Return lung; Spleen; Stomach; Liver Channel.Function warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling.The cold pain of main gastral cavity abdomen; Dyspepsia; Dysentery; Flu; Cough; Infantile convulsion; Leucorrhea; Hernia; The testis swelling and hanging down of either of the testes; Scrofula; Treating swelling and pain by traumatic injury; Carbuncle sore tumefacting virus; Venom.

Radix Pentasacmi championii another name five, southern stone Herba seu Radix Metaplexis hemsleyanae, false fourth Diao Zhu, Herba Pteridis Multifidae, full grass, Radix Homonoiae Ripariae, be the herb of dicotyledon medicine asclepiadaceae stone Herba seu Radix Metaplexis hemsleyanae PendasacmechampioniiBenth..Bitter in the mouth; Micro-pungent; Cool in nature.Return liver; Gallbladder meridian.Function is fallen apart wind heat clearing away; Removing toxic substances and promoting subsidence of swelling.Main anemopyretic cold; Cough; Pharyngalgia; Conjunctival congestion; Hepatitis; Venom.

Rhizoma Arisaemati another name LUBIANHUANG, Serpentis Semen Maydis, old Serpentis Semen Maydis are the tuber of aroid Rhizoma Arisaemati ArisaemasikokianumFuanch. day or full edge Rhizoma Arisaemati Sav.var.s day tatum (Makino) Hand.-Mazz [A.sazensoovar.serratumMakino] 2.ArisaemasikokianumFranch. day Sav..Bitter in the mouth, pungent; Warm in nature.Return lung; Liver Channel.Function drying dampness to eliminate phlegm; Relieving spasm by subduing liver-wind; Reducing swelling and alleviating pain.Main productive cough due to phlegm-damp; Dizziness due to wind-phlegm; Epilepsy; Apoplexy; Facial hemiparalysis; Tetanus; Carbuncle; Venom.

Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching calls large plumage crescent Herba pteridii latiusculi, Coniogramme japonica (Thunb.) Diels, derives from fern Athyriaceae Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching Abacopterismultilineata(Wall.) Ching, is used as medicine with root stock.Bitter in the mouth, cold in nature.Function dredge the meridian passage, dampness removing of regulating the flow of vital energy.Cure mainly impairment caused by overstrain, peratodynia, dysentery, menoxenia.

Herba Limnophilae rugosae another name Tian Gencao, water mint, Rhizoma begoniae pedatifidae, water Herba Schizonepetae, ripples perfume, wrinkle leaf Herba Limnophilae sessiliflorae are the herb of goatweed Limnophila rugosa NitellaexpansaAllen, Limnophilarugosa (Roth) Merr..Acrid in the mouth; Sweet; Warm in nature.Return lung; Spleen; Stomach warp.Function invigorating spleen to remove dampness; Activating QI to eliminate phlegm.Main edema; Stomachache; Distension and fullness of the chest and abdomen; Cough; Children's's infantile dyspepsia; Furuncle.

Radix Teucrii Pernyi another name Mount Lushan spice, derives from Labiatae and spends Phryganeajaponica Ml. TeucriumpernyiFranch. in vain, be used as medicine with root.Taste is micro-sweet, warm in nature.Function invigorating spleen to remove dampness, removing toxic substances.Cure mainly dysentery.

Herba lespedezae pilosae another name Herba cassiae torae, derives from pulse family Lespedeza plant Herba lespedezae pilosae Lespedezapilosa(Thunb.) Sieb. day Zucc., is used as medicine with root and Herb.Bitter in the mouth, pungent, property is put down.Function heat clearing away eliminating stagnation, promoting blood circulation and stopping pain, line water detumescence.For lymphoid tuberculosis, cold abscess, deficiency-heat is not moved back, edema, waist hamstring osteodynia; Mastitis are controlled in external.

Folium Coreopsis lanceolatae another name Coreopsis lanceolata, sword-like leave coreopsis, derive from Compositae Folium Coreopsis lanceolatae CoreopsislanceolataL., with all herbal medicine.Acrid in the mouth, property is put down.Function blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.Cure mainly knife injury, innominate toxic swelling.

In medicine of the present invention, Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; Herba Lysionoti Pauciflori heat clearing and damp drying, reducing swelling and alleviating pain; Radix Pimpinellae Candolleanae promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling; Radix Pentasacmi championii falls apart wind heat clearing away, removing toxic substances and promoting subsidence of swelling; Rhizoma Arisaemati drying dampness to eliminate phlegm, reducing swelling and alleviating pain; Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching dredge the meridian passage, regulating QI to expel dampness; Herba Limnophilae rugosae, Radix Teucrii Pernyi invigorating spleen to remove dampness, activating QI to eliminate phlegm; Herba lespedezae pilosae heat clearing away eliminating stagnation, promoting blood circulation and stopping pain; Folium Coreopsis lanceolatae blood stasis dispersing and deswelling, heat-clearing and toxic substances removing.All medicines share, and play heat-clearing and toxic substances removing altogether, promoting blood circulation to remove obstruction in the collateral, blood stasis-eliminating and stagnation-dissipating, the effect of reducing swelling and alleviating pain.It is evident in efficacy that treatment fat milk seepage causes phlebitis, and pain relieving time, redness disappear and damaged skin cure time all obtains comparatively promising result, and simple to operate, cost, patient are acceptant.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

One is treated fat milk and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:

Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 60g.

Method of preparation and use: be ground into fine powder by after each composition Chinese medicine mixing of medicine of the present invention, for subsequent use.Get fine powder when using appropriate, mix well deposited affected part with water, Chinese liquor, tea, vinegar, Ovum Gallus domesticus album, vaseline, Oleum sesami, Oleum Camelliae or glycerol etc.

Embodiment 2

One is treated fat milk and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:

Chinese fanpalm seed 50g, Herba Lysionoti Pauciflori 70g, Radix Pimpinellae Candolleanae 50g, Radix Pentasacmi championii 70g, Rhizoma Arisaemati 50g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 70g, Herba Limnophilae rugosae 50g, Radix Teucrii Pernyi 70g, Herba lespedezae pilosae 50g, Folium Coreopsis lanceolatae 70g.

Method of preparation and use is with embodiment 1.

Embodiment 3

One is treated fat milk and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:

Chinese fanpalm seed 70g, Herba Lysionoti Pauciflori 50g, Radix Pimpinellae Candolleanae 70g, Radix Pentasacmi championii 50g, Rhizoma Arisaemati 70g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 50g, Herba Limnophilae rugosae 70g, Radix Teucrii Pernyi 50g, Herba lespedezae pilosae 70g, Folium Coreopsis lanceolatae 50g.

Method of preparation and use is with embodiment 1.

Embodiment 4

One is treated fat milk and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:

Chinese fanpalm seed 40g, Herba Lysionoti Pauciflori 60g, Radix Pimpinellae Candolleanae 40g, Radix Pentasacmi championii 60g, Rhizoma Arisaemati 40g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 60g, Herba Limnophilae rugosae 40g, Radix Teucrii Pernyi 60g, Herba lespedezae pilosae 40g, Folium Coreopsis lanceolatae 60g.

Method of preparation and use is with embodiment 1.

Embodiment 5

One is treated fat milk and is caused phlebitic pharmaceutical composition, and each crude drug weight proportion is as follows:

Chinese fanpalm seed 60g, Herba Lysionoti Pauciflori 40g, Radix Pimpinellae Candolleanae 60g, Radix Pentasacmi championii 40g, Rhizoma Arisaemati 60g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 40g, Herba Limnophilae rugosae 60g, Radix Teucrii Pernyi 40g, Herba lespedezae pilosae 60g, Folium Coreopsis lanceolatae 40g.

Method of preparation and use is with embodiment 1.

Carried out clinical pharrnacokinetics test to medicine of the present invention, Details as Follows:

1 data and method

1.1 physical data

80 examples are selected to cause phlebitic patient be divided into two groups at random because vein inputs fat emulsion injection (Huarui Pharmaceutical Co. Ltd.).Often organize each 4O people, wherein male 38 people, female 42 people, 52.3 years old mean age; Severe Acute Pancreatitis SAP 62 example, tumor 14 example, malnutrition 4 example.Two groups, at age, sex, site of puncture, the equal no significant difference of phlebitis degree (P>0.05), have comparability.

1.2 method

1.2.1 the pharmaceutical composition fine powder that observation group gets the appropriate embodiment of the present invention 1 as required spreads in treatment bowl, add a little Mel mixing furnishing pasty state, be applied to phlebitic position equably, scope exceedes pain or red and swollen edge 1-2cm, apply two-layer sterile gauze, again with preservative film parcel, immobilization with adhesive tape 1 ~ 7 day is a course for the treatment of.

1.2.2 matched group with 50% magnesium sulfate 50g be dissolved in the warm water of 100mL (40-45 DEG C), soak with two-layer gauze after melting, be screwed onto and do not drip, spread on swelling place outward, scope exceedes red and swollen edge 1-2cm, with preservative film parcel, fix, 2-3 time/d, observe 3d, 5d therapeutic effect of post-evaluation, patient pain is alleviated, redness disappears and damaged skin cure time.

1.2.3 statistical method enumeration data adopts SPSS11.O statistical package to process data, adopts χ ²inspection, P<0.05 thinks that difference has statistical significance.

2 results

Comparitive study after 2.1 liang of group treatment 3d

It is 87.5% that total effective rate after 3 days is treated by observation group, and apparently higher than matched group (77.5%), two groups are compared (P<0.05), and difference has statistical significance.

Comparitive study after 2.2 liang of group treatment 5d

It is 100% that total effective rate after 5 days is treated by observation group, and apparently higher than matched group (9O%), two groups are compared (P<O.05), and difference has statistical significance.

2.3 liang of group patient pain alleviation, redness are disappeared, skin cure time compares

Observation group's pain relief, redness are disappeared, skin cure time is all shorter than matched group (P<0.05), and difference has statistical significance, in table 1.

Table 1 liang group patient pain alleviation, redness are disappeared, skin cure time compares (h)

Group	n	Pain relieving time	Red and swollen regression time	Skin cure time
					Observation group	40	5.51±1.82	12.56±1.49	56.42±24.49
Matched group	40	7.50±0.95	18.85±2.03	63.53±40.68

Claims (3)

1. treat fat milk and cause a phlebitic pharmaceutical composition, be made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 4-6 part, Herba Lysionoti Pauciflori 4-6 part, Radix Pimpinellae Candolleanae 4-6 part, Radix Pentasacmi championii 4-6 part, Rhizoma Arisaemati 4-6 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 4-6 part, Herba Limnophilae rugosae 4-6 part, Radix Teucrii Pernyi 4-6 part, Herba lespedezae pilosae 4-6 part, Folium Coreopsis lanceolatae 4-6 part.

2. treatment fat milk according to claim 2 causes phlebitic pharmaceutical composition, it is characterized in that, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 5-7 part, Herba Lysionoti Pauciflori 5-7 part, Radix Pimpinellae Candolleanae 5-7 part, Radix Pentasacmi championii 5-7 part, Rhizoma Arisaemati 5-7 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5-7 part, Herba Limnophilae rugosae 5-7 part, Radix Teucrii Pernyi 5-7 part, Herba lespedezae pilosae 5-7 part, Folium Coreopsis lanceolatae 5-7 part.

3. treatment fat milk according to claim 2 causes phlebitic pharmaceutical composition, it is characterized in that, is made up of the Chinese medicine of following weight portion:

Chinese fanpalm seed 6 parts, Herba Lysionoti Pauciflori 6 parts, Radix Pimpinellae Candolleanae 6 parts, Radix Pentasacmi championii 6 parts, Rhizoma Arisaemati 6 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 6 parts, Herba Limnophilae rugosae 6 parts, Radix Teucrii Pernyi 6 parts, Herba lespedezae pilosae 6 parts, Folium Coreopsis lanceolatae 6 parts.