CN1034574C - 5-氧取代的(rs)-2-(2，3-二氢-4，6，7-三甲基苯并呋喃基)乙酸衍生物的制备方法 - Google Patents

5-氧取代的(rs)-2-(2，3-二氢-4，6，7-三甲基苯并呋喃基)乙酸衍生物的制备方法 Download PDF

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Publication number
CN1034574C
CN1034574C CN89107028A CN89107028A CN1034574C CN 1034574 C CN1034574 C CN 1034574C CN 89107028 A CN89107028 A CN 89107028A CN 89107028 A CN89107028 A CN 89107028A CN 1034574 C CN1034574 C CN 1034574C
Authority
CN
China
Prior art keywords
dihydro
methyl
hydroxyl
compound
trimethylbenzofuryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN89107028A
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English (en)
Chinese (zh)
Other versions
CN1042354A (zh
Inventor
布鲁法尼·马里奥
塞卡埃里·斯台法诺
吉安尼蒂·帕特里加
派萨诺·阿哥尼赛
苏里·罗莫洛
扎拿莱拉·瑟吉奥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomedica Foscama Industria Chimico Farmaceutica SpA
Original Assignee
Biomedica Foscama Industria Chimico Farmaceutica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Biomedica Foscama Industria Chimico Farmaceutica SpA filed Critical Biomedica Foscama Industria Chimico Farmaceutica SpA
Publication of CN1042354A publication Critical patent/CN1042354A/zh
Application granted granted Critical
Publication of CN1034574C publication Critical patent/CN1034574C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
CN89107028A 1988-08-01 1989-08-01 5-氧取代的(rs)-2-(2，3-二氢-4，6，7-三甲基苯并呋喃基)乙酸衍生物的制备方法 Expired - Fee Related CN1034574C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT21603 1988-08-01
IT8821603A IT1229482B (it) 1988-08-01 1988-08-01 Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici.

Publications (2)

Publication Number Publication Date
CN1042354A CN1042354A (zh) 1990-05-23
CN1034574C true CN1034574C (zh) 1997-04-16

Family

ID=11184201

Family Applications (1)

Application Number Title Priority Date Filing Date
CN89107028A Expired - Fee Related CN1034574C (zh) 1988-08-01 1989-08-01 5-氧取代的(rs)-2-(2，3-二氢-4，6，7-三甲基苯并呋喃基)乙酸衍生物的制备方法

Country Status (15)

Country Link
US (2) US4999350A (enExample)
JP (1) JPH0278675A (enExample)
KR (1) KR0129526B1 (enExample)
CN (1) CN1034574C (enExample)
BE (1) BE1003255A5 (enExample)
CA (1) CA1324134C (enExample)
CH (1) CH679583A5 (enExample)
DE (1) DE3925496A1 (enExample)
ES (1) ES2014188A6 (enExample)
FR (1) FR2634766A1 (enExample)
GB (1) GB2221463B (enExample)
HK (1) HK48693A (enExample)
IT (1) IT1229482B (enExample)
SE (1) SE469652B (enExample)
SG (1) SG26693G (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231341B (it) * 1989-08-18 1991-11-28 Foscama Biomed Chim Farma 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche.
IT1239946B (it) * 1990-03-12 1993-11-27 Biomedica Foscama Industria Chimicofarmaceutica Procedimento per la sintesi degli acidi 5-acilossi e 5-alcossi-2,3-diidro-4,6,7-trimetil-2-(rs)-benzofuranacetici
US5240956A (en) * 1990-11-07 1993-08-31 Cortech, Inc. Ester inhibitors
EP0550292A1 (en) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Tissue protective tocopherol analogs
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
ATE158287T1 (de) * 1992-04-06 1997-10-15 Merrell Pharma Inc Derivate von 2,3-dihydro-2,2,4,6,7-pentaalkyl-5- benzofuranen
TW393475B (en) * 1992-10-16 2000-06-11 Chugai Pharmaceutical Co Ltd 4-alkoxyl-2,6-di-t-butyl phenol derivatives
IT1289494B1 (it) * 1996-12-20 1998-10-15 Biomedica Foscana Ind Chimico Acidi 5-idrossi- e 5-acilossi-2,3-diidro-4,6,7-trimetil-2- benzofuranaceti e loro esteri per il trattamento e la prevenzione
IT1320131B1 (it) * 2000-12-21 2003-11-18 Foscama Biomed Chim Farma Uso degli acidi 5-idrossi e 5-acilossi-2,3-diidro-4,6,7-trimetil-2-benzofuranacetici e loro esteri come cicatrizzanti delle lesioni

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6388173A (ja) * 1986-09-30 1988-04-19 Kuraray Co Ltd ２，３−ジヒドロベンゾフラン誘導体
US4857576A (en) * 1983-09-20 1989-08-15 Mitsubishi Kasei Corporation Method for rendering a flammable polymer material flame-resistant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537903A (en) * 1983-10-12 1985-08-27 Merck & Co., Inc. Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents
US4918092A (en) * 1983-12-21 1990-04-17 Merck Frosst Canada, Inc. Leukotriene antagonists
CA1281325C (en) * 1984-06-20 1991-03-12 Patrice C. Belanger Benzofuran derivatives
EP0273647B1 (en) * 1986-12-27 1992-03-11 Takeda Chemical Industries, Ltd. Coumaran derivatives, their production and use
JP2855340B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 ２―置換クマラン誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857576A (en) * 1983-09-20 1989-08-15 Mitsubishi Kasei Corporation Method for rendering a flammable polymer material flame-resistant
JPS6388173A (ja) * 1986-09-30 1988-04-19 Kuraray Co Ltd ２，３−ジヒドロベンゾフラン誘導体

Also Published As

Publication number Publication date
SE8902603D0 (sv) 1989-07-26
DE3925496C2 (enExample) 1992-04-30
DE3925496A1 (de) 1990-02-22
JPH0278675A (ja) 1990-03-19
GB8917515D0 (en) 1989-09-13
GB2221463B (en) 1992-03-25
CN1042354A (zh) 1990-05-23
US5041568A (en) 1991-08-20
CH679583A5 (enExample) 1992-03-13
KR900003145A (ko) 1990-03-23
SE8902603L (sv) 1990-02-02
FR2634766A1 (fr) 1990-02-02
ES2014188A6 (es) 1990-06-16
US4999350A (en) 1991-03-12
HK48693A (en) 1993-05-27
IT8821603A0 (it) 1988-08-01
IT1229482B (it) 1991-09-03
SG26693G (en) 1993-05-21
BE1003255A5 (fr) 1992-02-11
FR2634766B1 (enExample) 1994-08-19
KR0129526B1 (ko) 1998-04-09
CA1324134C (en) 1993-11-09
GB2221463A (en) 1990-02-07
SE469652B (sv) 1993-08-16

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C06 Publication
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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee