CN103432586B - 一种药用辅料黄原胶及其制备方法 - Google Patents
一种药用辅料黄原胶及其制备方法 Download PDFInfo
- Publication number
- CN103432586B CN103432586B CN201310374701.7A CN201310374701A CN103432586B CN 103432586 B CN103432586 B CN 103432586B CN 201310374701 A CN201310374701 A CN 201310374701A CN 103432586 B CN103432586 B CN 103432586B
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- Prior art keywords
- xanthan gum
- solution
- calcium chloride
- filament
- ethanol
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000230 xanthan gum Substances 0.000 title claims abstract description 77
- 229920001285 xanthan gum Polymers 0.000 title claims abstract description 77
- 229940082509 xanthan gum Drugs 0.000 title claims abstract description 77
- 235000010493 xanthan gum Nutrition 0.000 title claims abstract description 77
- 239000000463 material Substances 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 25
- 239000001110 calcium chloride Substances 0.000 claims abstract description 25
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 25
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 20
- 235000010355 mannitol Nutrition 0.000 claims abstract description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 7
- 229930195725 Mannitol Natural products 0.000 claims abstract description 5
- 239000000594 mannitol Substances 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 50
- 238000003756 stirring Methods 0.000 claims description 22
- 238000001035 drying Methods 0.000 claims description 18
- 229940064457 osmitrol Drugs 0.000 claims description 15
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 8
- 239000003513 alkali Substances 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 230000018044 dehydration Effects 0.000 claims description 7
- 238000006297 dehydration reaction Methods 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- 235000013373 food additive Nutrition 0.000 abstract description 2
- 239000002778 food additive Substances 0.000 abstract description 2
- 238000007670 refining Methods 0.000 abstract description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 1
- 229940107700 pyruvic acid Drugs 0.000 abstract 1
- 238000005185 salting out Methods 0.000 abstract 1
- 235000011121 sodium hydroxide Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 36
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 238000002835 absorbance Methods 0.000 description 8
- 239000002253 acid Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229910052785 arsenic Inorganic materials 0.000 description 4
- -1 arsenic salt Chemical class 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229910001385 heavy metal Inorganic materials 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 239000013558 reference substance Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201310374701.7A CN103432586B (zh) | 2013-08-24 | 2013-08-24 | 一种药用辅料黄原胶及其制备方法 |
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CN201310374701.7A CN103432586B (zh) | 2013-08-24 | 2013-08-24 | 一种药用辅料黄原胶及其制备方法 |
Publications (2)
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CN103432586A CN103432586A (zh) | 2013-12-11 |
CN103432586B true CN103432586B (zh) | 2014-12-10 |
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CN201310374701.7A Active CN103432586B (zh) | 2013-08-24 | 2013-08-24 | 一种药用辅料黄原胶及其制备方法 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109481690A (zh) * | 2019-01-23 | 2019-03-19 | 谭淞文 | 一种新型微晶甘露醇药用辅料 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101768615A (zh) * | 2010-02-11 | 2010-07-07 | 淄博中轩生化有限公司 | 一种黄原胶的制备方法 |
CN102838683A (zh) * | 2012-09-18 | 2012-12-26 | 江苏神华药业有限公司 | 一种低分子量黄原胶及其制备方法 |
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2013
- 2013-08-24 CN CN201310374701.7A patent/CN103432586B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101768615A (zh) * | 2010-02-11 | 2010-07-07 | 淄博中轩生化有限公司 | 一种黄原胶的制备方法 |
CN102838683A (zh) * | 2012-09-18 | 2012-12-26 | 江苏神华药业有限公司 | 一种低分子量黄原胶及其制备方法 |
Non-Patent Citations (8)
Title |
---|
"Xanthan production by Xanthomonas campestris in batch cultures";M.Papagianni, et al.;《Process Biochemistry》;20010628;第37卷;第74页右列最后1段 * |
"黄原胶的提取分离技术";逯伟防;《信阳农业高等专科学校学报》;19980815;第8卷(第3期);第57-58页第2部分 * |
"黄原胶纯化工艺研究进展";韩冠英;《中国生化药物杂志》;20120220;第33卷(第1期);第88-89页第2.3部分 * |
"黄原胶降解及其抗氧化性能研究";孙涛等;《天然产物研究与开发》;20120115;第24卷;第102-103页第1.2部分 * |
M.Papagianni, et al.."Xanthan production by Xanthomonas campestris in batch cultures".《Process Biochemistry》.2001,第37卷73-80. * |
孙涛等."黄原胶降解及其抗氧化性能研究".《天然产物研究与开发》.2012,第24卷102-104、113. * |
逯伟防."黄原胶的提取分离技术".《信阳农业高等专科学校学报》.1998,第8卷(第3期),56-58. * |
韩冠英."黄原胶纯化工艺研究进展".《中国生化药物杂志》.2012,第33卷(第1期),87-89. * |
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CN103432586A (zh) | 2013-12-11 |
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Owner name: JIANGSU FUFENG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: JIANGSU SHENHUA PHARMACEUTICAL CO., LTD. Effective date: 20140827 |
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Inventor after: Huang Mengmeng Inventor after: Xu Guohua Inventor after: Wang Yingyan Inventor after: Wang Xiyan Inventor after: Jia Cunjiang Inventor after: Zhang Furong Inventor before: Huang Mengmeng Inventor before: Xu Guohua Inventor before: Wang Yingyan Inventor before: Wang Xiyan Inventor before: Jia Cunjiang |
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Free format text: CORRECT: INVENTOR; FROM: HUANG MENGMENG XU GUOHUA WANG YINGYAN WANG XIYAN JIA CUNJIANG TO: HUANG MENGMENG XU GUOHUA WANG YINGYAN WANG XIYAN JIA CUNJIANG ZHANG FURONG |
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Effective date of registration: 20140827 Address after: 211600 Jinhu, Jiangsu Province, Shenhua Road, No., No. 188 Applicant after: JIANGSU FUFENG BIOLOGICAL TECHNOLOGY CO., LTD. Address before: 211600 Jinhu, Jiangsu Province, Shenhua Road, No., No. 188 Applicant before: Jiangsu Shenhua Pharmaceutical Co.,Ltd. |
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