CN103431485B - Health-preserving health-caring beverage - Google Patents
Health-preserving health-caring beverage Download PDFInfo
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- CN103431485B CN103431485B CN201310309395.9A CN201310309395A CN103431485B CN 103431485 B CN103431485 B CN 103431485B CN 201310309395 A CN201310309395 A CN 201310309395A CN 103431485 B CN103431485 B CN 103431485B
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- 235000013361 beverage Nutrition 0.000 title claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 241000756943 Codonopsis Species 0.000 claims description 6
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 5
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 5
- 244000077995 Coix lacryma jobi Species 0.000 claims description 5
- 240000001008 Dimocarpus longan Species 0.000 claims description 5
- 235000000235 Euphoria longan Nutrition 0.000 claims description 5
- 235000017309 Hypericum perforatum Nutrition 0.000 claims description 5
- 244000141009 Hypericum perforatum Species 0.000 claims description 5
- 244000241838 Lycium barbarum Species 0.000 claims description 5
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 5
- 240000002853 Nelumbo nucifera Species 0.000 claims description 5
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 5
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 5
- 244000242564 Osmanthus fragrans Species 0.000 claims description 5
- 235000019083 Osmanthus fragrans Nutrition 0.000 claims description 5
- 244000082204 Phyllostachys viridis Species 0.000 claims description 5
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 5
- 239000009759 San-Chi Substances 0.000 claims description 5
- 244000185386 Thladiantha grosvenorii Species 0.000 claims description 5
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 claims description 5
- 239000011425 bamboo Substances 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- 231100000753 hepatic injury Toxicity 0.000 claims description 3
- 206010067125 Liver injury Diseases 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241001122767 Theaceae Species 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 23
- 230000009182 swimming Effects 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 13
- 239000000047 product Substances 0.000 description 12
- 238000003304 gavage Methods 0.000 description 11
- 238000012360 testing method Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 7
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 7
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 7
- 238000012449 Kunming mouse Methods 0.000 description 4
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 206010021143 Hypoxia Diseases 0.000 description 2
- 101100503585 Mus musculus Furin gene Proteins 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- YRSGDLIATOURQO-UHFFFAOYSA-N ethyl 4-acetyl-5-oxohexanoate Chemical compound CCOC(=O)CCC(C(C)=O)C(C)=O YRSGDLIATOURQO-UHFFFAOYSA-N 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 210000001557 animal structure Anatomy 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229960002335 bromhexine hydrochloride Drugs 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 231100000132 chronic toxicity testing Toxicity 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000013010 irrigating solution Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002279 physical standard Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
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- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention relates to a health-preserving health-caring beverage, and aims at providing a tea substitute capable of dispelling alcohol effect. The raw material compositions comprise radix polygonimultifloripreparata. The raw materials are respectively crushed, sieved and then mixed, and then are packed into bags.
Description
Technical field
The invention belongs to a kind of health beverages, particularly relate to a kind of health-care beverage, drink for people's four seasons health.
Background technology
Along with the increase of social pressures, a lot of people are in sub-health state.People have not met the expensive price of the health products on market, and just progressively exploitation has the health beverages of certain market prospects.
Summary of the invention
Object of the present invention is to provide a kind of substitute of tealeaves, a kind of health beverages, the object that is beneficial to sober up.
A kind of health-care beverage, raw material composition comprises RADIX POLYGONI MULTIFLORI PREPARATA.
A kind of health-care beverage, raw material composition comprises RADIX POLYGONI MULTIFLORI PREPARATA, Radix Codonopsis, tealeaves, Radix Glycyrrhizae.
A kind of health-care beverage, its raw material is pulverized respectively, mixes bag distribution packaging after sieving.
A kind of health-care beverage, its raw material composition comprises RADIX POLYGONI MULTIFLORI PREPARATA, Radix Codonopsis, tealeaves, Radix Glycyrrhizae, matrimony vine, sweet osmanthus, hypericum perforatum, longan, dried orange peel, coix seed, Momordica grosvenori, the seedpod of the lotus, bamboo shoots, sanchi flower.
A kind of health-care beverage, its raw material composition comprises 1～2 part of RADIX POLYGONI MULTIFLORI PREPARATA, 1～2 part of Radix Codonopsis, 100～240 parts of tealeaves, 1～2 part, Radix Glycyrrhizae, 1～2 part of matrimony vine, 1～2 part of sweet osmanthus, 1～2 part of hypericum perforatum, 1～2 part of longan, 1～2 part of dried orange peel, 1～2 part of coix seed, 1～2 part of Momordica grosvenori, 1～2 part of the seedpod of the lotus, 1～2 part, bamboo shoots, 1～2 part of sanchi flower.
Detailed description of the invention
Embodiment 1:
A kind of health-care beverage, its raw material consists of 1 part of RADIX POLYGONI MULTIFLORI PREPARATA, 1 part of Radix Codonopsis, 100 parts of tealeaves, 1 part, Radix Glycyrrhizae, 1 part of matrimony vine, 1 part of sweet osmanthus, 1 part of hypericum perforatum, 1 part of longan, 1 part of dried orange peel, 1 part of coix seed, 1 part of Momordica grosvenori, 1 part of the seedpod of the lotus, 1 part, bamboo shoots, 1 part of sanchi flower.Pulverize respectively, sieve, then fully mix, then use pouch bag distribution packaging.
Embodiment 2:
A kind of health-care beverage, its raw material consists of 2 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 2 parts of Radix Codonopsis, 240 parts of tealeaves, 2 parts, Radix Glycyrrhizae, 2 parts of matrimony vines, 2 parts of sweet osmanthus, 2 parts of hypericum perforatums, 2 parts of longan, 2 parts of dried orange peels, 2 parts of coix seeds, 2 parts of Momordica grosvenoris, 2 parts of the seedpod of the lotus, 2 parts, bamboo shoots, 2 parts of sanchi flowers.Pulverize respectively, sieve, then fully mix, then use pouch bag distribution packaging.
Embodiment 3 safety evaluatios
Acute toxicity test in mice: test shows, cannot accurately record embodiment 1LD 50 with mouse stomach administration.
Rat acute toxicity test: embodiment 1 product gavage 7 days, the maximum dosage of the rat of administration is 10g/kgBW, actually belongs to nontoxic level.
Three genicity tests: embodiment 1 product result is negative.
Rat chronic toxicity test experiment: embodiment 1 product gavage 3 months, every biochemical indicator demonstration, animal organ dissects, with control group comparison, without overt toxicity effect.
Embodiment 4
Alcoholic Hepatic Injury is affected
Choose ICR male mice 20-22 gram, feed with standard feed, freely drink water, adaptability enters test after feeding.Before test, fasting 12 hours, weighs for every, label, grouping, 10 every group.Each group mouse, according to the dosage of 0.2ml/10g give the low dosage of embodiment 1 product, middle dosage, high dose (0.2g/kgbw), in (0.4g/kgbw), high (1g/kgbw), model group feedwater 0.2mL/10g, after 30min, by 0.15mL/10g gavage Erguotou wine (56%); After 6h, put to death mouse, take immediately 012g fresh liver and put into and be equipped with precooling glass homogenizer, make 100g/L homogenate in ice bath, the centrifugal 10min of 2000r/min, gets supernatant, is LH, measures the content of MDA.Observation is subject to the impact of test product on Alcoholic Hepatic Injury.
Product of the present invention can obviously reduce the level (* P < 0.05) of MDA in mouse liver
Specific embodiment 5 product of the present invention can strengthen muscle power
1, animal used as test
Kunming mouse, male, 20-22 gram, 10, every cage, looks for food and the freedom of drinking water, room temperature (25 ± 2) DEG C, natural lighting.
2, experimental technique
Forced swimming experiment: mouse is put into 10 centimetres of the depth of waters, and graduated cylinder (height is 20 centimetres, and diameter the is 14 centimetres) went swimming of water temperature (24 ± 1) DEG C, makes it produce the feared state of mind, takes out at 30 DEG C and will hairyly do after 5 minutes.In 24 hours, respectively with drink to animal used as test gavage, then mouse is put into above-mentioned environment, measure mouse and in latter 4 minutes of 6 minutes, keep the motionless time of swimming.
Using the shortening of dead time as judging whether drink strengthens physical standard.
This experiment is mice group, 10 every group.
Blank group, gives the physiological saline with drug study group equivalent;
Embodiment 1 product group, low dosage, middle dosage, high dose (0.2g/kgbw), in (0.4g/kgbw), high (1g/kgbw).
In the hairy same time of doing in latter 24 hours of mouse, respectively organize gavage.Be and be divided into gavage three times.
3, experimental result
1) forced swimming experimental result is in Table
Each group mouse forced swimming dead time
Can be found out by result, after gavage, the various dose group of 1 group of drink of embodiment all significantly reduces the mouse forced swimming dead time, can strengthen the muscle power of animal.
The resistance to anoxic experiment of mouse normal pressure
1, animal used as test
Kunming mouse, male, 20-22 gram, 10, every cage, looks for food and the freedom of drinking water, room temperature (25 ± 2) DEG C, natural lighting.
2, experimental technique
The resistance to anoxic experiment of mouse normal pressure: after mouse last gavage 4h, every group of 10 mouse, are placed in mouse respectively the airtight wide-mouth bottle of 125ml that soda lime 7.5g is housed, and after sealing, its time-to-live of observed and recorded, taking breath stopped as dead indication.
Gavage method:
Blank group, gives the physiological saline with drug study group equivalent;
Embodiment 1 product group, low dosage, middle dosage, high dose (0.2g/kgbw), in (0.4g/kgbw), high (1g/kgbw).
Experimental result:
On the impact of the resistance to the survival time under hypoxic condition of mouse normal pressure, in Table, compared with control group, embodiment of the present invention 1-3 organizes tested mouse fur light, usually more active, and none animal dead can significantly improve mouse normal pressure hypoxia-bearing capability.
Mice burden swimming experiment
1, animal used as test
Kunming mouse, male, 20-22 gram, 10, every cage, looks for food and the freedom of drinking water, room temperature (25 ± 2) DEG C, natural lighting.
2, experimental technique
Mice burden swimming experiment: after mouse last gavage 4h, every group of 10 mouse, be one to be the weight of its weight 5% at every mouse tail, put into the swimming trunk went swimming of 110cm × 60cm × 70cm, depth of water 20cm, water temperature is 30 ± 0.5 DEG C, all enters the lasting 8s of water and can not emerge as judging terminal, the record swimming exhaustion time with mouse head.
Gavage method:
Blank group, gives the physiological saline with medicine group equivalent;
Embodiment 1 product group, low dosage, middle dosage, high dose (0.2g/kgbw), in (0.4g/kgbw), high (1g/kgbw).
On the impact of mice burden swimming ability, in Table, compared with control group, embodiment of the present invention 1-3 organizes tested mouse fur light, usually more active, and none animal dead, can significantly improve mice burden swimming ability.
Experimental result shows that product of the present invention time-to-live in anaerobic environment and swimming with a load attached to the body experiment is significantly longer than control group, has the resistance to anoxic of significant enhancing mouse and anti-fatigue ability, has higher value of exploiting and utilizing.
Embodiment 6: the resolve phlegm effect of pharmaceutical composition of the present invention
The impact of pharmaceutical composition of the present invention on the phenol red excretion of mouse
Experimental technique
Phenol red Specification Curve of Increasing: take phenol red 1.95mg in electronic analytical balance, add 5%NaHCO
3to 3.9ml dissolving, containing phenol red amount 0.5mg/ml, as stoste.Get stoste 0.1ml and add 5%NaHCO
33.9ml dissolves, and obtaining concentration is 12.5 μ g/ml.And be diluted to successively 10 μ g/ml, 5 μ g/ml, 3 μ g/ml, 1 μ g/ml, 0.7 μ g/ml, 0.3 μ g/ml, 0.1 μ g/ml.Use ultraviolet/visible light spectrophotometer (UVmini.1240, SHIMADZU) to survey OD value, drawing standard curve in 546nm place.
Get the KM mouse (before experiment, fasting 16 hours, can't help water) of body weight 20 ± 2g, random packet, 10 every group.Be respectively: blank group (distilled water); Bromhexine hydrochloride (9.6mg/kg); Embodiment 1 low dose group (10mg/kg); Dosage group (20mg/kg) in embodiment 1; Embodiment 1 high dose group (30mg/kg); The present embodiment 4 gained effervescent tablet groups (10mg/kg).All take gastric infusion mode for each group, administration volume is 10ml/kg, 1 time/d, and 3d continuously.30min after last administration, in the phenol red normal saline solution 0.1ml/10g of lumbar injection 5%, after injection, the de-neck of 30min is put to death.Cut off skin of neck, separate tracheae, trachea cannula and be connected with syringe, use 5%NaHCO
30.8ml, slowly injects in tracheae, then sucking-off gently, 3 times so repeatedly, merge 3 times irrigating solution, place certain hour and make contamination precipitation, the transparent red supernatant obtaining, is used ultraviolet/visible light spectrophotometer (UVmini.1240, SHIMADZU) to survey OD value in 546nm place.Calculate phenol red content (μ g/ml) according to calibration curve.Data processing: experimental data, all to represent, adopts statistic software SPSS 15.0 to carry out one-way analysis of variance.
Experimental result
Compare with blank group, pharmaceutical composition of the present invention and bromhexine hydrochloride group all can significantly promote the phenol red excretion of mouse.
Note: compared with blank group, * P < 0.05, * * P < 0.01
Claims (1)
- For alcoholic liver injury, strengthen the preparation method of physical health-care beverage, it is characterized in that:Its raw material consists of 1 part of RADIX POLYGONI MULTIFLORI PREPARATA, 1 part of Radix Codonopsis, 100 parts of tealeaves, 1 part, Radix Glycyrrhizae, 1 part of matrimony vine, 1 part of sweet osmanthus, 1 part of hypericum perforatum, 1 part of longan, 1 part of dried orange peel, 1 part of coix seed, 1 part of Momordica grosvenori, 1 part of the seedpod of the lotus, 1 part, bamboo shoots, 1 part of sanchi flower, pulverize respectively, sieve, then fully mix, then use pouch bag distribution packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310309395.9A CN103431485B (en) | 2013-07-23 | 2013-07-23 | Health-preserving health-caring beverage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310309395.9A CN103431485B (en) | 2013-07-23 | 2013-07-23 | Health-preserving health-caring beverage |
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| Publication Number | Publication Date |
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| CN103431485A CN103431485A (en) | 2013-12-11 |
| CN103431485B true CN103431485B (en) | 2014-11-19 |
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| CN201310309395.9A Active CN103431485B (en) | 2013-07-23 | 2013-07-23 | Health-preserving health-caring beverage |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1240590A (en) * | 1998-06-30 | 2000-01-12 | 肖树恩 | Health-care toffee |
| CN1593177A (en) * | 2004-07-01 | 2005-03-16 | 汕头市生奥保健食品有限公司 | Vegetable fruit flower tea and its preparation method |
| CN102396621A (en) * | 2011-11-05 | 2012-04-04 | 安徽省天旭茶业有限公司 | Chinese medicinal tea cream and preparation method thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211393A (en) * | 1997-09-16 | 1999-03-24 | 天重平 | Health-care tea beverage |
| CN1586248B (en) * | 2004-10-15 | 2011-10-12 | 高思 | Health drink |
| CN101006817A (en) * | 2007-01-24 | 2007-08-01 | 邓天华 | Bamboo leaf tea and its producing method |
| CN101554195A (en) * | 2008-04-10 | 2009-10-14 | 刘泳宏 | Natural mind-tranquilizing brain-strengthening tea and processing method thereof |
| CN101554196A (en) * | 2008-04-10 | 2009-10-14 | 刘泳宏 | Natural thirsty-removing hypoglycemic tea and processing method thereof |
| CN101554194A (en) * | 2008-04-10 | 2009-10-14 | 刘泳宏 | Natural skin-nourishing body-building tea and processing method thereof |
| CN101564069A (en) * | 2008-04-23 | 2009-10-28 | 刘泳宏 | Natural blood enriching and kidney nourishing tea and processing method |
| CN101564071A (en) * | 2008-04-23 | 2009-10-28 | 刘泳宏 | Natural spleen strengthening and stomach nourishing tea and processing method |
| CN101564190A (en) * | 2008-04-23 | 2009-10-28 | 刘泳宏 | Natural liver nourishing and visual acuity improving tea and processing method |
| CN101961062B (en) * | 2010-05-24 | 2013-04-03 | 蔡霄英 | Ginseng beauty tea and production and preparation method thereof |
-
2013
- 2013-07-23 CN CN201310309395.9A patent/CN103431485B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1240590A (en) * | 1998-06-30 | 2000-01-12 | 肖树恩 | Health-care toffee |
| CN1593177A (en) * | 2004-07-01 | 2005-03-16 | 汕头市生奥保健食品有限公司 | Vegetable fruit flower tea and its preparation method |
| CN102396621A (en) * | 2011-11-05 | 2012-04-04 | 安徽省天旭茶业有限公司 | Chinese medicinal tea cream and preparation method thereof |
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Effective date of registration: 20151221 Address after: 100176, No. 5, building 2, No. 22, Zhonghe street, Beijing economic and Technological Development Zone, Beijing Patentee after: BEIJING KANG LISHENG PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. Address before: 100176 No. 22 Zhonghe street, Beijing economic and Technological Development Zone, Beijing Patentee before: Cheng Gang |