A kind of nourishing iced tea that relieves the effect of alcohol
The present invention is a kind of sobering-up health-care iced tea, be specifically a kind ofly there is invigorating the spleen benefit liver, reduce internal heat quench the thirst, Dealcoholic sobering-up, orectic nourishing alcohol-decomposing beverage tea.
Current various beverage iced tea or health protection tea are various in style on market, and function is extensive, but existing market also lacks and a kind ofly can nourishing the liver protect stomach, and the drink of makeup energy of relieving the effect of alcohol can reduce internal heat again.
At present, due to economic fast development, private car has entered majority's family, due to the impact of spirits culture for thousands of years, the situation that causes most drivers to drive when intoxicated, causing thus the traffic accident causing by driving when intoxicated also increases year by year, as can be seen here, work as driver, high-altitude builder, or the various crowds that forbid operation after drinking, the potential safety hazard that operation after drinking brings is provided food for thought, sign in this, invent a kind of effect balancing and protect the liver the refrigerant orectic nourishing of the relieving the effect of alcohol iced tea that relieves the effect of alcohol, this class crowd's needs have been met, liked the crowd of spirits culture to bring gratifying spring again.
The object of the invention is to provide a kind of invigorating the spleen benefit liver, reduces internal heat and quenches the thirst, Dealcoholic sobering-up, orectic sobering-up health-care tea.
The composition of raw materials of the nourishing iced tea that relieves the effect of alcohol of the present invention is as follows: by every hundred kg of water dosing (raw material) kg, calculate below
Coloured malt 1kg-2kg dried peppermint leaf 0.5kg-1.5kg
Mung bean sprouts 1kg-2kg fruit of Chinese wolfberry 0.5kg-1.5kg
Root of kudzu vine 1kg-2kg chrysanthemum 1kg-2kg
Dried orange peel 0.5kg-1.5kg radix bupleuri 0.5kg-1.5kg
Rhizoma zingiberis 1kg-2kg Poria cocos 0.5kg-1.5kg
Radix Glycyrrhizae 1kg-kg lophatherum gracile 1kg-2kg
Hawthorn 1kg-3kg rock sugar 1kg-2kg
The preferred mass proportioning of above-mentioned each component is as follows:
Coloured malt 1.5kg dried peppermint leaf 1kg
Mung bean sprouts 1.5kg fruit of Chinese wolfberry 1kg
Root of kudzu vine 1.5kg chrysanthemum 1.5kg
Dried orange peel 1kg radix bupleuri 1kg
Rhizoma zingiberis 1.5kg Poria cocos 1kg
Radix Glycyrrhizae 1.5kg lophatherum gracile 1.5kg
Hawthorn 2kg rock sugar 1.5kg
With above-mentioned formula, be Chinese medicinal ingredients, existing that micro-medicine composition formula of the present invention is as follows:
Health protection tea drink of the present invention includes the trace element that various needed by human body are wanted, its elementary composition sees that content is how many, by country, formulating consumption standard adds, or the content that uses the consumption of grand ceremony > > to press per kilogram water with reference to < < national drug adds, (due to the content percentage of its former medicine of can not coming to a conclusion, medicine Jun You used manufacturer determines).The present invention's trace element used is preliminary experiment consumption.Sincerely for reference:
(former powder or stoste)
1 grape glycogen powder, 3% 7 steviosides 1%
2 xylitols, 2.5% 8 Sodium Benzoates 0.1%
3 white granulated sugars, 2% 9 vitamin Cs 0.3%
4 calcium lactates, 1.5% 10 vitamin B1s 0.25%
5 citric acids, 0.5% 11 vitamin B2s 0.2%
6 salt compounded of iodine 0.25%
The component of above-mentioned formula of take is raw material, can adopt conventional extraction process to extract its effective ingredient, is prepared into beverage, and as health protection tea, oral liquid, also can be encapsulated by pulverizing after above-mentioned component convection drying.
Ingredients preparation of the present invention is reasonable, effect balancing, wherein:
Fructus Hordei Germinatus is monarch drug in a prescription, and nature and flavor are sweet flat, return spleen, stomach, Liver Channel.Have help digestion and in, lower gas delaactation, soothing liver and strengthening spleen effect; Mung bean sprouts is worked as ministerial drug, and nature and flavor are sweet cool, return stomach, the heart channel of Hang-Shaoyin, and removing toxic substances, dampness removing, < < Compendium of Materia Medica > > says: " relieving alcoholism, heat poison, sharp three warmers "; The root of kudzu vine is ministerial drug: sweet, flat, enter spleen, and stomach warp, promoting eruption, promotes the production of body fluid to quench thirst, relieving alcoholism.Rhizoma zingiberis is adjutant: pungent, heat, enters the heart, liver lung, and spleen, stomach warp, warming spleen and stomach for dispelling cold, four sun are promoted blood circulation, dry temperature dissolving phlegm.Hawthorn is adjutant: the sweet tepor of nature and flavor acid, enters spleen, stomach, Liver Channel.Help digestion and amass, stagnation resolvation antidiarrheal.Radix bupleuri is for making medicine, and hardship is pungent, is slightly cold, and enters liver, gallbladder channel, and in inducing sweat, soothing the liver liter sun.Poria cocos is for making medicine: sweet, light, flat, enter the heart, spleen, lung channel.Ooze Wen Lishui, beneficial spleen and stomach, antitoxic heart-soothing and sedative.
Fructus Hordei Germinatus and mung bean sprouts or the root of kudzu vine, one monarch's two ministers, have help digestion and in, pleasant, relieving muscles to expel heat, promoting eruption, promote the production of body fluid to quench thirst, relieving alcoholism, heat poison, profit three warmers, the effect of balance the body state balance, coloured malt and hawthorn are the good merchantable brand of digestion-promoting spleen-invigorating altogether, be total to and promoted human body to digest and assimilate effect, hawthorn regulating qi to disperse stagnation, stomach invigorating is promoted the production of body fluid, the root of kudzu vine has Dealcoholic sobering-up effect from ancient times, add again the relieving alcoholism effect of mung bean sprouts, another and Radix Glycyrrhizae neutralizes, to the reaction of relieving the effect of alcohol, more obvious, so: to the crowd who does not drink: as children, women, also there is heat-clearing, removing toxic substances, relieving muscles to expel heat, the effect of promoting the production of body fluid to quench thirst, be more suitable for most of crowds, gas under dried orange peel stomach invigorating, open chest, peppermint and chrysanthemum wind-dispelling heat-dissipating, ward off dirty removing toxic substances, removing heat to brighten vision, matrimony vine and Radix Glycyrrhizae, nourishing liver and kidney, improving eyesight moistening lung, invigorate the spleen and benefit qi, clearing heat and detoxicating, moisten the lung and relieve the cough, relieving restlessness, reduce internal heat, clearing lung-heat heat, diuresis, promote the production of body fluid, sober up.Number medicine coordinates, and monarch is clear and definite, and effect is outstanding, plays altogether strengthening spleen, tonifying kidney, and Dealcoholic sobering-up moistens life, delays senility.
The present invention is in pharmacological action, added in right amount again the indispensable trace element of human body: as vitamin C, or vitamin B1 B2: the glucose of liver is protected in diuresis, the effect that is Dealcoholic sobering-up is more obvious, strengthens the calcium lactate of human body, the allusion quotation salt quenching the thirst fast, give and more lack vitamin C, comprehensively supplementing of vitamin B1 B2 and calcium, thus solved, sober up, limbs fatigue, remember unclear, visual impairment, or expelling pathogenic factors from muscles for clearing heat, the effect of preventing phlegm from forming and stopping coughing, bring more fully energy supplement to more crowd, play nourishing life, delaying senility function.
The method for making of health beverages medicinal tea of the present invention is as follows:
Front ten four traditional Chinese medicine thing compositions are put into pot, add purify waste water boiled, cold 5-10 minute, then add carbohydrate and trace element, sterilization, can bottle after filtration.
Easy to carry for more crowds, medicine preferred dosage form of the present invention " capsule " and method for making as follows:
By coloured malt, mung bean sprouts, the root of kudzu vine, dried orange peel, rhizoma zingiberis, Radix Glycyrrhizae, hawthorn, dried peppermint leaf, the fruit of Chinese wolfberry, chrysanthemum, radix bupleuri, Poria cocos, lophatherum gracile, rock sugar is in proportion, mix, add 75% alcohol immersion and cross powder, refluxing extraction three times, each 1.5-2.0 hour, extract merges, and reduced pressure concentration obtains medicinal extract (25 ℃ of proportion 1.30-1.40).Medicinal extract vacuum drying.
By carbohydrate and microelement powder or liquid blending, after vacuum drying, after pulverizing, mix with front 14 taste dry drugs, cross sieve No. 4.During medicinal powder is incapsulated and get final product.
The present invention keeps healthy and nourishes drink or medicine, reasonable recipe not only, effect is balanced, and has the function of good stomach strengthening and digestion promoting Dealcoholic sobering-up, can also play the effect that regulates immunologic mechanism, be a kind of health drink tea or capsule pharmaceutical that most people is drunk or taken that be suitable for.
Experimental example 1
The evaluation of effect of medicine of the present invention (in this experiment, the commodity antialcoholism capsule that nourishes by name, lower same) functions of strengthening stomach and promoting digestion.
The impact of 1, mouse small intestine being wriggled
Materials and methods
Animal used as test: KM mouse, male and female half and half.Non-inbred strais closed colony.Body weight: 25.34 ± 2.23.Purchased from Chinese Academy of Medical Sciences's Institute of Botany.Card number: moving word (07) 01-3001 of doctor.
Tested medicine: nourish antialcoholism capsule.This institute new drug research center provides.Lot number: 090928.0.45g/ grain.
Test method: get mouse and be divided at random four groups, 10 every group.Give respectively the medicine that contains 0.5g/ml active carbon of various dose.Within 30 minutes after 1 administration, put to death mouse.Separated small intestine, minute survey small intestine total length and and charcoal not forward position to the length of small intestine terminal.Calculate charcoal off-duty length and charcoal off-duty length percentage [=charcoal off-duty length/small intestine total length %].Administration volume, 0.2ml/10g.
Test grouping:
Grouping drug dose (g/kg/)
1 distilled water
2 digestion-promoting stomachics 3.36
3 nourish antialcoholism capsule 0.2
4 nourish antialcoholism capsule 1.2
Positive control drug: digestion-promoting stomachic.Jiang Zhong pharmaceutical factory produces.0.8g/ sheet.Lot number: 09060033. function with cure mainly:
Stomach strengthening and digestion promoting.For weakness of the spleen and the stomach, indigestion.
Result
Table 1 nourishes the impact (x ± s) of antialcoholism capsule energy mouse small intestine motion
Compare with the 1st group,
*p < 0.05.n=10。
Conclusion
Nourishing antialcoholism capsule moves without obvious effect to mouse small intestine.
2, the impact on mouse food-intake
Materials and methods
Animal used as test: KM mouse, male and female half and half.Non-inbred strais closed colony.Body weight: 16.9 ± 2.93.Purchased from Chinese Academy of Medical Sciences's Institute of Botany.Card number: moving word (07) 01-3001 of doctor.
Tested medicine: nourish antialcoholism capsule.This institute new drug research center provides.Lot number 090928.0.45g/ grain.
Experimental technique: get mouse and be divided at random four groups.Every group 20 (every group is divided again four boxes to raise.5/box).Give respectively the medicine of various dose.Be administered once every day.Successive administration 10 days.Respectively at the 24 hours food-intakes of the 1st, 3,5,7,10 days mensuration mouse before administration and after administration.
Experiment grouping: the same.
Positive control drug: digestion-promoting stomachic.Jiang Zhong pharmaceutical factory produces.0.8g/ sheet.Lot number: 09060033.Function with cure mainly: stomach strengthening and digestion promoting.For weakness of the spleen and the stomach, indigestion.
Result
Table 2 nourishes antialcoholism capsule to the impact of mouse food-intake (x ± s)
Compare with the 1st group,
*p < 0.05.n=20。
Conclusion
Nourish antialcoholism capsule and there is the effect that certain promotion mouse is taken food.Positive control drug is without obvious effect.
3, the impact on intestinal absorption effect
Materials and methods
Experimental animal: KM mouse, male and female half and half.Non-inbred strais closed colony.Body weight: 16.9 ± 2.93.Purchased from Institute of Zoology, Academia Sinica.Card number: moving word (07) 01-3001 of doctor.
Tested medicine: nourish antialcoholism capsule.This institute new drug research center provides.Lot number: 090928.0.45g/ grain.
Test method: KM mouse is divided into 5 groups at random.Every group 10 (the 5th group 4).Give respectively the medicine of various dose.Be administered once every day.Successive administration 10 days.After administration in the 10th day, mouse fasting is 12 hours.In second day, test.During test, every mouse stomach includes the GC liquid (the 5th group to equal-volume distilled water) of 10% glucose and 5% cholesterol.0.2ml/10g。Within after gavage 20 minutes, pluck eyeball and get blood, separation of serum is surveyed blood sugar and cholesterol level.Used kit is all purchased from Zhong Sheng biochemical reagents company.Lot number: 090407,090405.Tester is ZS-1A semi-automatic biochemical analyzer.
Test grouping:
Grouping modeling drug dose (g/kg)
1 GC liquid distilled water
2 GC liquid digestion-promoting stomachics 3.36
3 GC liquid nourish antialcoholism capsule 0.2
4 GC liquid nourish antialcoholism capsule 1.2
5 distilled water distilled water
Positive control drug: digestion-promoting stomachic.Jiang Zhong pharmaceutical factory produces.0.8g/ sheet.Lot number: 09060033.Function with cure mainly: stomach strengthening and digestion promoting.For weakness of the spleen and the stomach, indigestion.
Result
Table 3 nourishes the impact (x ± s) that antialcoholism capsule absorbs mouse small intestine
Compare △ △ △ P < 0.05, P < 0.01 with the 3rd group.
Compare with the 5th group,
*?
*p < 0.05, P < 0.01.n=10。
Conclusion
Nourishing antialcoholism capsule has the effect of certain promotion intestinal absorption.But dose-effect relationship is not obvious.
The regulating action evaluation of experimental example 2 medicine of the present invention to immunologic function
1, the effect to mouse carbon particle clearance
Materials and methods
Experimental animal: KM mouse, male and female half and half.Non-inbred strais closed colony.Body weight: 21.12 ± 1.89.Purchased from Chinese Academy of Medical Sciences's Institute of Botany.Card number: moving word (07) 01-3001 of doctor.
Tested medicine: nourish antialcoholism capsule.This institute new drug research center provides.Lot number: 090928.0.45g/ grain.
Test method: get mouse and be divided at random 4 groups.Every group 10.Give respectively the medicine of various dose.Be administered once every day.Successive administration 10 days.After administration in the 10th day 1 hour, the india ink of mouse tail vein injection dilution (with 4 times of normal saline dilutions).0.1ml/10g。Respectively at 2,10 minutes mouse angular vein clumps after injection india ink, get blood 20ul, and be dissolved in 2ml0.1%Na2CO3 liquid, with 752 spectrophotometers at 600nm place photometry density value.And make blank with Na2CO3.
After mouse is put to death, get liver, spleen, weighs, the standby phagocytic index (a) of calculating.
Index is expressed: K value=(logOD1-logOD2)/(t2-t1)
A=body weight/(liver weight+spleen weight) 3 K
Test grouping:
Positive control drug: digestion-promoting stomachic.Jiang Zhong pharmaceutical factory produces.0.8g/ sheet.Lot number: 090928.Function with cure mainly: stomach strengthening and digestion promoting.For weakness of the spleen and the stomach, indigestion.
Result
Table 4 nourishes the impact (x ± s) of antialcoholism capsule on mouse carbon granules exterior feature and spleen weight
Compare with the 1st group,
*p < 0.05.n=10。
Conclusion
Nourishing antialcoholism capsule has the effect of certain promotion mouse monokaryon macrophage phagocytic.Low dose has obvious effect.
2, the impact on mouse spleen lymphocyte transformation
Materials and methods
Experimental animal: KM mouse, part of speech.Non-inbred strais closed colony.Body weight: 20.83 ± 1.02g.Purchased from Chinese Academy of Medical Sciences's Institute of Botany.Card number: moving word (07) 01-3001 of doctor.
Tested medicine: nourish antialcoholism capsule.This institute new drug research center provides.Lot number: 090928.1.45g/ grain.
Reagent: RPMI1640 nutrient solution (Sigma).Acid isopropyl alcohol liquid (adding 4mllmol/LHCl in 96ml isopropyl alcohol liquid).MTT(sigma)。ConA(Sigma)。
Test method: get mouse and be divided at random 4 groups.Every group 3.Give respectively the medicine of various dose.Be administered once every day.Successive administration 7 days.Within 1 hour after administration in the 7th day, put to death mouse, the aseptic spleen of getting, extracts T cell.Adjusting cell concentration is 2 * 10
6cell/ml.Divide 2 holes to add in 24 well culture plates in cell liquid, 1ml/ hole.And do not add ConA liquid control wells.Add CoaA concentration 100ug/ml 50ul.Be placed in 5%CO2, cultivate 72 hours for 37 ℃.Cultivation finishes first 4 hours, and every hole adds 5mg/ml MTT50ul/ hole.Continue to cultivate 4 hours.After cultivation finishes, do not have hole to add 1ml acid isopropyl alcohol, piping and druming mixes, and purple crystal is dissolved completely.Then divide and be filled in 96 orifice plates, every hole packing 3 holes.With 318MC ELIASA, detect wavelength 570nm.Calculate T ability of cell proliferation (=OD adds conA-OD and do not add conA).T cell proliferation percentage [=(OD adds conA-OD and does not add conA/OD and do not add conA].
Test grouping:
Positive control drug: digestion-promoting stomachic.Jiang Zhong pharmaceutical factory produces.0.8g/ sheet.Lot number: 090928.Function with cure mainly: stomach strengthening and digestion promoting.For weakness of the spleen and the stomach, indigestion.
Result
Table 5 nourishes the impact (x ± s) of antialcoholism capsule on mouse spleen T cell proliferation function
Compare with the 1st group,
*?
*p < 0.05, P < 0.01.n=3。
Conclusion
Nourish antialcoholism capsule and have the ability that promotes that spleen lymphocyte transforms, this product has invigorating the spleen benefit liver, relieves the effect of alcohol and the advantage such as fast of sobering up.With heavy dose of successful.