CN103416421B - Ternary active compound combinations - Google Patents

Ternary active compound combinations Download PDF

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CN103416421B
CN103416421B CN201310362351.2A CN201310362351A CN103416421B CN 103416421 B CN103416421 B CN 103416421B CN 201310362351 A CN201310362351 A CN 201310362351A CN 103416421 B CN103416421 B CN 103416421B
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plant
compound
seed
conjugate
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CN103416421A (en
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L·阿斯曼
D·施图布勒
U·威辰道福-诺伊曼
P·达门
H·亨格伯格
E·括普曼
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Bayer Intellectual Property GmbH
Bayer CropScience AG
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01B—SOIL WORKING IN AGRICULTURE OR FORESTRY; PARTS, DETAILS, OR ACCESSORIES OF AGRICULTURAL MACHINES OR IMPLEMENTS, IN GENERAL
    • A01B79/00—Methods for working soil
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01C—PLANTING; SOWING; FERTILISING
    • A01C1/00—Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01C—PLANTING; SOWING; FERTILISING
    • A01C1/00—Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
    • A01C1/08—Immunising seed
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G7/00—Botany in general
    • A01G7/06—Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/50—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids the nitrogen atom being doubly bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/10—Sulfones; Sulfoxides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Soil Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Ecology (AREA)
  • Forests & Forestry (AREA)
  • Botany (AREA)
  • Mechanical Engineering (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Catching Or Destruction (AREA)

Abstract

The present invention relates to active agent combinations, the particularly active agent combinations in antibacterial or insecticides, it includes (A) 3,4 dichloro N (2 cyano-phenyl) 5 isothiazole formamides and (B) imidacloprid and (C) a kind of parasite killing or Fungicidal active compound.In addition; the invention still further relates to a kind of therapeutic or preventative preventing and treating plant or the phytopathogen of crop and/or microorganism and/or the method for insect; relate to the conjugate of the present invention for processing the purposes in plant propagation portion, relate to a kind of method protecting seed, and relate to treated seed.

Description

Ternary active compound combinations
The application is the name submitting, entering on January 27th, 2010 National Phase in China to international office on July 15th, 2008 It is referred to as the divisional application of No. 200880100589.5 applications for a patent for invention of " ternary active compound combinations ".
The present invention relates in active agent combinations (combination), particularly antibacterial or insecticides Active agent combinations, it includes that (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide is (general entitled different Metsulfovax (isotianil), Cas 224049-04-1) and (B) imidacloprid (imidacloprid) and (C) a kind of parasite killing or Fungicidal active compound.Moreover, it relates to a kind of plant for curatively or prophylactically preventing and treating plant or crop Pathogen and/or microorganism and/or the method for insect, relate to conjugate of the present invention for processing the purposes in plant propagation portion, relate to And a kind of method protecting seed, and relate to treated seed.
Known (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide has sterilization and insecticidal properties.Additionally, Also find that Isothiazolcarboxylicacid acid derivatives is very suitable for protecting plant antagonism undesirable plant pathogen and the invasion and attack (US-of microorganism A5240951 and JP-A06-009313).The compound (A) of the present invention had both been suitable to transfer plant to undesirable plant pathogen and micro- The defence of biological attack, it is possible to as microbicide for directly preventing and treating phytopathogen and microorganism.Additionally, compound (A) insect the most active (WO99/24414) to infringement plant.
Compound (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide and preparation thereof are disclosed in WO99/ In 24414.The activity of this compound is good；But, under low rate of application sometimes and unsatisfactory.
Compound (B) is imidacloprid, and it is a kind of insecticidal active compound, is disclosed in EP-A0192060.Compound (C) selected from following sterilization and insecticidal active compound: ethiprole (ethiprole, it is known that in DE-A19653417), ethiprole (fipronil, it is known that in EP-A00295117), thiacloprid (thiacloprid, it is known that in EP-A0235725), kill more Rhzomorph (spinosad, it is known that in EP-A0375316), thiophene fluorine bacterium amine (thifluzamide, it is known that in EP A0371950 In), the chloro-N of (S)-3-1-{ 2-methyl-4-[1,2,2,2-tetra-fluoro-1-(trifluoromethyl) ethyl] phenyl }-N2-(1-methyl-2-first Base sulfonyl ethyl) phthalic amide (being known in EP-A1006107) and N-[2-(1,3-dimethylbutyl) phenyl]-5- Fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (being known in WO03/010149).
Compound (B) is recorded in documents below (WO2005/122796 with the binary combinations of one of described compound (C)； EP-A0871362、WO2005/036966、WO1999/060857；WO2007/101542；WO2006/114212) in.It is known that Isotianil is applicable to prevent and treat phytopathogen (WO2005/009131) with the conjugate of anabasine.
Additionally, due to modern fungicides and the environment of insecticide and economic requirement such as action spectrum, toxicity, Requirement in terms of selectivity, rate of application, the formation of residue and favourable preparative capacibility improves constantly, and may deposit Such as to known activity compound produce resistance problem, therefore, exploitation the most in some aspects relative to known correspondence The advantageous new antibacterial of thing and insecticide are long-range missions.
The invention provides the active agent combinations/compositions reaching described target the most in some aspects.
It has now, surprisingly, been found that the conjugate of the present invention not only makes phytopathogen to be prevented and treated and/or micro-life The action spectrum of thing and/or insect be able to additivity improve, but also create cooperative effect can in terms of two expanded compound (A), compound (B) and the sphere of action of compound (C).First, compound (A), compound (B) and compound (C) are reduced Rate of application, maintain like good effect simultaneously.Secondly, even if when the single compound of these three is completely ineffectively low Time in the range of rate of application, described conjugate remains to obtain higher phytopathogen control effect.This makes on the one hand, significantly to open up The pedigree of the wide phytopathogen that can prevent and treat, on the other hand, enhances safety in utilization.
But, except, in addition to the actual synergism in terms of sterilization and insecticidal activity, the Pesticidal combinations of the present invention also has There is the advantageous property of other surprising more broadly upper alternatively referred to as synergistic activity.The example of the described advantageous property that can be mentioned that Have: for other phytopathogen and/or microorganism and/or insect such as the sterilization widened of resistant strain Compose with insecticidal activity；The active component rate of application reduced；By the present composition enough preventing and treatings to nuisance, even if at list Also it is such under the rate of application that only compound is completely ineffective；Advantageous property during preparation or when using, such as grinding, Screening, emulsifying, advantageous property when dissolving or distribute；The storage stability improved；The light stability improved；More favourable drops Xie Xing；The toxicological properties improved or ecotoxicology performance；The characteristic of the useful plants improved, including: emergence rate (emergence), crop yield, more flourishing root system, tiller (tillering) increase, plant height increase, blade are bigger, base is raw Leaf mortality rate is lower, tiller is higher, leaf color fertilizer greener, required seed less, required is less, tiller is more voluminous, bloom earlier, Kernel maturity is early, plant less lodges (verse, lodginig), shoot growth improves, improve plant growing way and rudiment are early； Or any further advantage well known to those skilled in the art.
The conjugate of the present invention also provides the interior absorption (systemicity) improved for reactive compound used.It practice, Even if some in Fungicidal compounds used do not have any interior absorption or gratifying interior absorption, these compounds are at this Bright compositions also can show such a performance.
Similarly, the conjugate of the present invention can improve the persistency of sterilization drug effect of used reactive compound.
It has also been discovered that to combine or to execute while compound (A), compound (B) and compound (C) that individually mode is carried out With, relative to single individualized compound (A), compound (B) and compound (C) or aforementioned binary mixture (WO05/ 009131), for, phytopathogen and/or microorganism and/or insect can more effectively be resisted.
Another advantage of conjugate of the present invention is to obtain the drug effect of raising.
Therefore, the present invention provides such a conjugate, comprising:
(A) the chloro-N-of 3,4-bis-(2-cyano-phenyl)-5-isothiazole formamide
With
(B) imidacloprid；With
(C) another is selected from following sterilization and the reactive compound of insecticidal active compound: ethiprole, ethiprole, thiophene Worm quinoline, pleocidin, thiophene fluorine bacterium amine, the chloro-N of (S)-3-1-{ 2-methyl-4-[1,2,2,2-tetra-fluoro-1-(trifluoromethyl) ethyl] Phenyl }-N2-(1-methyl-2-methysulfonylethyl) phthalic amide and N-[2-(1,3-dimethylbutyl) phenyl]-5- Fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide.
Compound (B) and most array (C) compound see pesticide handbook (Pesticide Manual) the 13rd edition, 2003.Compound (C) is listed with common name.If there is no available common name, then compound before the priority date of the application (C) list with IUPAC name.
Preferably conjugate is listed below:
● compound (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) imidacloprid and Compound (C) ethiprole,
● compound (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) imidacloprid and Compound (C) ethiprole,
● compound (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) imidacloprid and Compound (C) thiacloprid,
● compound (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) imidacloprid and Compound (C) pleocidin,
● compound (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) imidacloprid and Compound (C) thiophene fluorine bacterium amine,
● compound (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) imidacloprid and Compound (C) (S) the chloro-N of-3-1-{ 2-methyl-4-[1,2,2,2-tetra-fluoro-1-(trifluoromethyl) ethyl] phenyl }-N2-(1-first Base-2-methysulfonylethyl) phthalic amide,
● compound (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) imidacloprid and Compound (C) N-[2-(1,3-dimethylbutyl) phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide.
The weight ratio of active compound component is chosen as being provided that required effect, such as synergism.Generally, described Weight ratio changes according to concrete reactive compound.Generally, the weight ratio between any two kinds of compounds is independently of one another 100:1 to 1:100, preferably 75:1 to 1:75, more preferably 50:1 to 1:50, and most preferably 25:1 to 1:25.The present invention can use Any two kinds of compounds between other part by weight be 250:1 to 1:250,200:1 to 1:200,150:1 independently of one another To 1:150, the preference degree of described ratio is strengthened successively by given order.
It is 90:1 to 1 independently of one another according to other weight ratio between the spendable any two kinds of compounds of the present invention: 90,80:1 to 1:80,70:1 to 1:70,60:1 to 1:60,40:1 to 1:40,30:1 to 1:30,10:1 to 1:10,5:1 to 1: 5,4:1 to 1:4,3:1 to 1:3, the preference degree of described ratio is strengthened successively by given order.
In the presence of compound (A), compound (B) and compound (C) can be with tautomeric forms, described compound exists Context is interpreted as under applicable circumstances also include corresponding tautomeric form, even if they are not distinguished one by one Mention.
Having the compound (A) of at least one basic center, compound (B) and compound (C) can be with the most following Kind of acid generates such as acid-addition salts: strong inorganic acid, such as mineral acid, such as perchloric acid, sulphuric acid, nitric acid, nitrous acid, phosphoric acid or hydrogen halogen Acid；Strong organic carboxyl acid, the most unsubstituted or substituted (such as halo) C1-C4Alkanecarboxylic acid such as acetic acid, saturated or unsaturated Dicarboxylic acids such as ethanedioic acid, malonic acid, succinic acid, cis-1, fumaric acid and phthalic acid, hydroxy carboxylic acid is the most anti-bad Hematic acid, lactic acid, malic acid, tartaric acid, citric acid or benzoic acid；Or organic sulfonic acid, as unsubstituted or substituted (such as halo ) C1-C4Alkane sulfonic acid or aryl sulfonic acid, such as methanesulfonic acid or p-methyl benzenesulfonic acid.There is the compound of at least one acid groups (A), compound (B) and compound (C) such as can generate salt, such as slaine, such as alkali metal salt or alkaline-earth metal with alkali Salt, such as sodium salt, potassium salt or magnesium salt；Or generate salt with ammonia or organic amine, described organic amine such as morpholine, piperidines, pyrrolidine, Single lower alkanols alkylamine, double lower alkanols alkylamine or three lower alkanols alkylamines (such as ethamine, diethylamine, triethylamine or dimethyl Propyl group amine) or monohydroxy lower alkanols alkylamine, double Hydroxyl lower alkyl group amine or trihydroxy lower alkanols alkylamine (such as single second Hydramine, diethanolamine or triethanolamine).Additionally, corresponding inner salt can optionally be formed.In the present invention, it is preferred in agrochemicals Favourable salt.In view of the tight pass between compound (A), compound (B) and the free form of compound (C) and its salt form System, suitable and favourable in the case of, any in context mention free compound (A), compound (B) and compound (C) or during their salt, it is thus understood that include the most respectively corresponding salt or free compound (A), compound (B) and Compound (C).This can equally be well applied to compound (A), compound (B) and the tautomer of compound (C) and salt thereof.
Term " conjugate " in the present invention represents compound (A), compound (B) and the various combinations of compound (C), example Combination such as following form: single " premix (ready-mix) " form；It is made up of the independent preparation of single-activity compound In conjunction with the form of spraying mixture, such as " bucket mixes "；And the form that is used in combination during independent active component sequential application, phase Continue to use and i.e. use one by one within the shortest the most several hours of the time or several days.Preferably, compound (A), change The order of administration of compound (B) and compound (C) is not necessary to practice the present invention.
Term " pathogen " in the present invention represents all organisms hurtful to plant or any plant part.
Term " fungus " in the present invention represents all of fungal organism and false bacterium organism (chromista Organism).
Term " phytopathogen " in the present invention represents all funguses hurtful to plant or any plant part Organism and false bacterium organism.The example of classification of fungi group has ascomycetes (Ascomycota), basidiomycetes (Basidiomycota), chytrid (Chytridiomycota), imperfect fungi (Deuteromycota), polymerization bacterium (Glomeromycota), microsporidian (Microsporidia), zygomycete (Zygomycota) and Fungi Imperfecti (anamorphic Fungi).The example of false bacterium is oomycetes (Oomycota).
Term " microorganism " in the present invention represents all of bacterial organism and protozoacide organism.Example is knee Bacterium (Plasmodiophoromycetes).
Term " viral " in the present invention represents all viruses hurtful to plant or any plant part.Example is DNA-, RNA and DNA and RNA retrovirus and subviral agent.
Term " insect " in the present invention represents all aschelminths hurtful to plant or any plant part (aschelminthes) organism and general arthropod (panarthropoda) organism.Example is Nematoda (Nematoda), Arthropoda (Arthopoda), Hexapoda (Hexapoda) and Arachnoidea (Arachnida).
Described reactive compound has strong microbiocidal activity, bactericidal activity and parasite killing in the compositions of the present invention and lives Property, and can be used for preventing and treating the undesirable plant pathogen in crop protection, material protection, veterinary field, herding and/or micro-life Thing and/or insect, and can be used as domestic pesticide.
In the present compositions, Fungicidal compounds can be used in crop protection, such as to prevent and treat phytopathogen And/or microorganism and/or insect, such as plasmodiophora brassicae, oomycetes, chytrid, zygomycete, ascomycetes, basidiomycetes and imperfect fungi.
In the present compositions, pesticide compound can be used in crop protection, such as to prevent and treat pathogenic evil Worm.
In the present compositions, bactericidal compound can be used in crop protection, such as to prevent and treat microorganism, such as vacation Sporangium (Pseudomonadaceae), root nodule bacteria (Rhizobiaceae), enterobacteria (Enterobacteriaceae), bar Bacterium (Corynebacteriaceae) and streptomycete (Streptomycetaceae).
The sterilization and disinsection conjugate of the present invention and/or compositions can be used for curatively or prophylactically preventing and treating plant or crop Phytopathogen and/or microorganism and/or insect.Therefore, another aspect of the present invention, it is provided that a kind of therapeutic or prevention Property ground preventing and treating plant or the phytopathogen of crop and/or microorganism and/or the method for insect, the method includes by with lower section Formula uses the fungicide insecticide compositions of a kind of present invention: be applied to seed, plant or fruit or plant is raw The long soil that maybe will grow.
All plants and plant part can be processed according to the present invention.Described plant refers to all plants and plant species Group, that such as need and unwanted wild plant, cultigen (including natural cultigen) and botanical variety (are whether subject to Botanical variety or plant breeder weigh protection).Cultigen and botanical variety can be to be obtained by Sterile culture and method of breeding The plant including transgenic plant, described Sterile culture and method of breeding can be aided with or supplement with one or more biological skills Art method, such as by using dihaploid, protoplast fusion, random mutagenesis and site directed mutagenesis, molecular marker or genetic marker, Or by biological engineering and genetic engineering method.
Described plant part refers to all grounds of plant and under ground portion and organ, such as bud, leaf, Hua Hegen, at this Aspect lists such as leaf, needle, stem, branch, flower, sporophore, fruit and seed and root, bulb and rhizome.Crop and asexual with Case of propagation material, such as, transplant, bulb, rhizome, sarment and seed, falls within plant part.
Term " plant propagation material " in the present invention represents that can be used in the asexual of plant or sexual propagation all are planted Thing material.The example of plant propagation material is transplanted, bulb, rhizome, sarment, seed, fruit, grain, soybean pod, sporophore, Tuber and seedling.
Phytopathogen and/or microorganism and/or the conjugate/compositions of the present invention of insect is resisted in crop protection Contain effective but do not have the reactive compound of the present invention of phytotoxic amount." effective but do not have phytotoxic amount " is fixed Justice is the amount of such a conjugate of the present invention, and its mushroom that on the one hand be enough to prevent and treat satisfactorily or be completely eliminated plant is sick Evil and another aspect are not result in any significant phytotoxicity symptom.Described effective dose generally can at one in a big way Interior change.This dosage depends on multiple factor, in the most targeted fungus, plant, weather conditions, and conjugate of the present invention Reactive compound.
In the plant can protected by the inventive method, the main field crops that can be mentioned that has, such as corn and soybean, Cotton Gossypii, Semen Brassicae Campestris oilseeds (Brassica oilseeds, such as cabbage type rape (Brassica napus) such as Canada Brassica campestris L (canola), Radix Brassicae rapae (Brassica rapa), Caulis et Folium Brassicae junceae (B.juncea) such as Caulis et Folium Brassicae junceae (mustard) and Ethiopia Russia Than sub-mustard (Brassica carinata)), rice, Semen Tritici aestivi, Radix Betae, Caulis Sacchari sinensis, Herba bromi japonici, rye (Secale cereale L.), Fructus Hordei Vulgaris, foxtail millet, black Semen Tritici aestivi, Caulis et Folium Lini, rattan This plant and the various fruit and vegetables of various plant classification group, such as Rosaceae belong to kind of (Rosaceae sp.) (such as a, a kind of fruit, such as apple, pear, etc. Such as Fructus Mali pumilae and pears, and drupe such as Fructus Pruni, Fructus Pruni pseudocerasi, almond and Fructus Persicae, berry such as Fructus Fragariae Ananssae), Ribesioidae sp., Juglandaceae belong to kind (Juglandaceae sp.), Betulaceae belong to kind (a Betulaceae sp.), Anacardiaceae belongs to kind (an Anacardiaceae sp.), Fagaceae belongs to kind of (a Fagaceae sp.), Moraceae belongs to kind of (a Moraceae sp.), Oleaceae belongs to kind of (Oleaceae sp.), a macaque Fructus Persicae section belongs to kind of (an Actinidaceae sp.), Lauraceae belongs to kind of (a Lauraceae sp.), Musaceae belongs to kind of (a Musaceae sp.) (such as Banana tree and plantation), Rubiaceae belong to kind of (Rubiaceae sp.) (a such as coffee), Theaceae belongs to kind an of (Theaceae Sp.), Sterculiaceae belongs to kind of (a Sterculiceae sp.), Rutaceae belongs to kind of (Rutaceae sp.) (such as Fructus Citri Limoniae, orange and a Fructus Vitis viniferae Fructus Citri grandis)；Solanaceae belongs to kind of (Solanaceae sp.) (such as Fructus Lycopersici esculenti, Rhizoma Solani tuber osi, Fructus Piperis, Fructus Solani melongenae, a colea), Liliaceae genus kind (Liliaceae sp.), Compositae belong to kind of (a Compositiae sp.), and (such as Caulis et Folium Lactucae sativae, arithoke and Herba Cichorii include root Herba Cichorii (root chicory), Herba Sonchi Arvensis (endive) or common Herba Cichorii (common chicory)), Umbelliferae belongs to kind (Umbelliferae sp.) (such as Radix Dauci Sativae, parsley, Herba Apii graveolentis and celeriac), Cucurbitaceae belong to kind of (a Cucurbitaceae sp.) (such as Fructus Cucumidis sativi includes pickled Fructus Cucumidis sativi (pickling cucumber), Fructus Cucurbitae moschatae, Citrullus vulgaris, calabash and Fructus Melo), Herba Alii fistulosi section belong to plants (Alliaceae sp.) (such as Bulbus Allii Cepae and leek (Allium porrum L.)), Cruciferae belong to kind of (a Cruciferae sp.) (such as white cabbage, red Cabbage, Caulis et Folium Brassicae capitatae, Brassica oleracea L. var. botrytis L., brussels sprout, Plantula Brassicae chinensis, kohlrabi, Radix Raphani (radish), Radix Cochleariae officinalis, Herba Oenanthes Javanicae, Chinese cabbage), Pulse family belongs to kind of (Leguminosae sp.) (such as Semen arachidis hypogaeae, Semen Pisi sativi and Kidney bean such as a climning bean and Semen Viciae fabae), Chenopodiaceae genus kind (Chenopodiaceae sp.) (such as fodder beet, foliage heet, Herba Spinaciae, table beet), Compositae belong to kind an of (Asteraceae Sp.) (such as Helianthi), Cruciferae (Brassicaceae sp.) (such as white cabbage, red cabbage, Caulis et Folium Brassicae capitatae, flower coconut palm Dish, brussels sprout, Plantula Brassicae chinensis, kohlrabi, Radix Raphani and canola, Brassica campestris L, Caulis et Folium Brassicae junceae, Radix Cochleariae officinalis and Herba Oenanthes Javanicae), pulse family (Fabacae sp.) (such as Semen arachidis hypogaeae and beans), Papilionaceae belong to kind of (Papilionaceae sp.) (such as Semen sojae atricolor), a Radix Malvae sylvestris Section (Malvaceae) (such as Flos abelmoschi manihot), Asparagaceae (Asparagaceae) (such as Germinatus Phragmitis)；Gardening and forest crop；View and admire Plant；And the congener of the genetic modification of described crop.
The processing method of the present invention can be used for processing genetically modified organisms (GMO), such as plant or seed.Genetic modification is planted Thing (or transgenic plant) is the plant that heterologous gene is stably integrated into genome.Described word " heterologous gene " refers mainly to this The gene carrying out providing or assembling outside plant of sample, when this gene introduces in core, chloroplast or mitochondrial genome lead to Protein that process LAN is paid close attention to or polypeptide or by lower or reticent one or more be present in other gene endophytic (such as using antisense technology, co-suppression technology or RNA interference-RNAi technology) thus give transformed gene plant new or improve Agronomy or other characteristic.The heterologous gene being positioned at genome is also referred to as transgenic.According to it in Plant Genome Particular location and the transgenic that defines is referred to as transformation plant or transgenic line (transformation or transgenic Event).
According to plant species or plant cultivars, its location and growth conditions (soil, weather, nutrient plant trophophase, battalion Support), the process of the present invention also can produce superadditivity (" working in coordination with ") effect.Thus can obtain the effect exceeding actual desired as follows Really: such as can reduce reactive compound used according to the invention and the rate of application of compositions and/or widen its activity profile and/or Improve its activity, improve plant growing, improve high temperature or cold tolerance, raising to arid or to saliferous in water or in soil The toleration of amount, improve Flowering quality, simpler, the hasting of maturity of making to gather, raising gather that productivity, fruit are bigger, plant height is higher, Leaf color is greener, the quality of harvested products of blooming earlier, improve and/or its nutritive value that improves, the sugared concentration improved in fruit, change The bin stability of kind harvested products and/or processing characteristics.
Under some rate of application, the active agent combinations of the present invention also can have strengthening effect in plant.Therefore, They are also suitably for adjusting vegeto-animal defense system, to resist the invasion and attack of undesirable plant pathogen and/or microorganism and/or virus. In a suitable case, this is probably one of conjugate of the present invention reason of activity raising resisting such as fungus.In this article, The implication of plant strengthening (induction of resistance) material is interpreted as the conjugate of such a material or material: they can stimulate plants The defense system of thing, thus when inoculating undesirable plant pathogen and/or microorganism and/or virus and/or insect subsequently, through place The plant of reason shows significant resistance to described undesirable plant pathogen and/or microorganism and/or virus and/or insect.? In the present invention, undesirable plant pathogen and/or microorganism and/or virus are understood to mean that phytopathogen, antibacterial and virus And/or insect.Therefore, the protection above-mentioned pathogen of plant resistant in the material of the present invention can be used for the regular period after the treatment Invasion and attack.The period realizing protection generally continues 1 to 10 day, preferred 1-7 days after processing plant with reactive compound.
The preferred plant to be processed of the present invention and plant cultivars include having the described plant of imparting, and (no matter it is by educating Kind and/or biological technique method obtain) all plants of the hereditary material of advantageous particularly, useful feature.
The preferred plant to be processed of the present invention and plant cultivars also can have resistance to one or more biotic, i.e. Described plant demonstrates for animal pests and microbial pests such as nematicide, insecticide, acarid, pathogenic The preferable defense of bacterium, antibacterial, virus and/or viroid.
Present invention plant to be processed and plant cultivars can be also that one or more abiotic stress are had resistance Those plants.Abiotic stress conditions can include such as arid, low temperature exposure, beat exposure, osmotic stress, waterflooding, increase The soil salinity, the mineral exposure of increase, ozone exposure, high light exposure, the availability of restricted nitrogen nutrient, restricted phosphorus The availability of nutrient, shelter from heat or light and avoid.
Present invention plant to be processed and plant cultivars can be also those plants of the yield characteristics with raising.Described The productivity of the raising of plant can by the plant physiology function such as improved, grow with grow as water-use efficiency, water holding efficiency, change The nitrogen that enters utilizes, improve carbon assimilation, the photosynthesis of improvement, the germination efficiency of raising and hasting of maturity and produce. Productivity also can be affected by the families of plant structure (plant architecture) (coercing and under non-stress condition) improved, The families of plant structure of described improvement includes but not limited to, bloom ahead of time, for hybrid seed produce controls of blooming, rice shoot work Power, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod number or spike number, every Individual pod or the seed number of fringe, seed quality, the seed plumpness of raising, the seed dispersal of reduction, the pod dehiscence of reduction and Lodging resistance.Yield characteristics also includes seed compositions, such as carbohydrate content, protein content, oil content and composition, battalion Support value, the reduction of anti-nutrient compounds, the processing characteristics of improvement and good bin stability.
It is listed in Table A while there is the example nonexhaustive of the plant of above-mentioned characteristic.
Table A
Crop Characteristic GMO List of references
All Water-use efficiency It is WO2000/073475
All Use nitrogen efficiency It is WO1995/009911
All Use nitrogen efficiency It is WO1997/030163
All The photosynthesis improved It is WO2003/000066
Semen sojae atricolor Nematicide No WO1995/020669
Semen Brassicae Campestris The pod dehiscence reduced It is WO2006/009649
Semen sojae atricolor Aphids resistance No WO2006/125065
Caulis et Folium Lactucae sativae Aphids resistance No WO1997/046080
Semen Brassicae Campestris Anti-Sclerotinia (Sclerotinia) No WO2006/135717
Fructus Lycopersici esculenti Anti-Botrytis (Botrytis) No WO2006/046861
Crop Characteristic GMO List of references
Caulis et Folium Lactucae sativae Anti-dish downy mildew (Bremia) No US20070022496
Rhizoma Solani tuber osi Anti-Ou Wenshi (Erwinia) No WO2004/049786
Fructus Cucumidis sativi Anti-Closterovirus (Closterovirus) No WO2002/022836
Fructus Capsici Antiviral No WO2006/038794
The plant processed according to the present invention can be the hybrid plant having given expression to hybrid vigor characteristic, and described characteristic would generally Cause higher productivity, vigor, health degree and to the biological and resistance of abiotic stress.Described plant is generally male by a kind of selfing Property sterile parent line (maternal) can educate parent line (paternal) male with another kind of selfing hybridize and prepare.Hybrid seed generally from male not Educate and plant is gathered and sells to grower.Male sterile plants (such as Semen Maydis) sometimes can be prepared by emasculation spica, i.e. machine Tool remove Male reproductive organ (or male flower), but, more generally, male sterility by the genetic determination in Plant Genome because of Son obtains.In the case, especially when hope from the product that hybrid plant is gathered be seed time, it is ensured that hybrid plant male The recovery completely of fertilizability is typically the most useful.This can be by assuring that paternal line has and suitably can recover hybrid plant and contain Have and cause the restoring gene of male sterile genetic determinant male fertility to realize.Male sterility heredity is certainly Determining cause can be located in Cytoplasm.The example of cytoplasmic male sterility (CMS) is at such as Btassica (Brassica Species) (WO92/05251, WO95/09910, WO98/27806, WO05/002324, WO06/021972 it are described in And US6,229,072).But, male sterility genetic determinant may be alternatively located in Matrix attachment region.Male sterile plants also can lead to Cross Plant Biotechnology rule such as genetic engineering and obtain.A kind of particularly useful method obtaining male sterile plants exists Being described in WO89/10396, the most such as ribonuclease such as barnase is carried out in the tapetal cell of stamen Optionally express.Then fertilizability can be by ribonuclease inhibitor such as barstar at tapetum Expression in cell and recover (such as WO91/02069).
The plant or the plant cultivars that process according to the present invention (are obtained by Plant Biotechnology rule such as genetic engineering ) can be herbicide tolerant plants, i.e. one or more given herbicides are had the plant of toleration.Described plant can be led to Cross genetic transformation or by selecting the plant of the sudden change containing the described herbicide tolerant of imparting to obtain.
Herbicide resistant plants has such as glyphosate (glyphosate) tolerant plants, i.e. to herbicide glyphosate or its Salt has the plant of toleration.Can make plant that glyphosate is had toleration by different methods.Such as, glyphosate tolerance Property plant can by with coding 5-enol pyruvylshikimate-3-phosphate synthase (5-enolpyruvylshikimate-3- Phosphate synthase, EPSPS) gene-transformed plant and obtain.The example of described EPSPS gene has mouse typhus sramana The AroA gene (mutant CT7) of Salmonella (Salmonella typhimurium) antibacterial (Comai et al., 1983, Science221,370-371), the CP4 gene of Agrobacterium kind (Agrobacterium sp.) antibacterial (Barry et al., 1992, Curr.Topics Plant Physiol., 7,139-145), coding petunia EPSPS gene (Shah et al., 1986, Science233,478-481), the gene of coding for tomato EPSPS (Gasser et al., 1988, J.Biol.Chem., 263,4280-4289) or coding Eleusine EPSPS gene (WO01/66704).Can also be such as EP0837944, The EPSPS of the sudden change described in WO00/66746, WO00/66747 or WO02/26995.Glyphosate-tolerant plant also can pass through Express the coding gene of glyphosate oxidoreductase and obtain, such as United States Patent (USP) No.5,776,760 and 5, described in 463,175. Glyphosate-tolerant plant also can obtain by expressing the gene of coding glyphosate acetyl transferase, such as WO02/36782, Described in WO03/092360, WO05/012515 and WO07/024782.Glyphosate-tolerant plant is also by selecting containing upper State the plant of the natural mutation of gene and obtain, such as described in WO01/024615 or WO03/013226.
Other herbicide resistant plants has the plant such as to the herbicide suppressing glutamine synthase with toleration, institute State herbicide such as bialaphos (bialaphos), grass fourth phosphine (phosphinothricin) or glufosinate-ammonium (glufosinate).Described plant by expressing the enzyme of this herbicide that detoxifies or can have the glutamine of resistance to inhibitory action Synthase mutant and obtain.A kind of described efficient solution toxenzyme is enzyme (the such as streptomycete of coding grass fourth phosphinothricin acetyl transferring enzyme (Streptomyces) bar or the pat albumen planted).The plant expressing exogenous grass fourth phosphinothricin acetyl transferring enzyme is special in the such as U.S. Profit No.5,561,236,5,648,477,5,646,024,5,273,894,5,637,489,5,276,268,5,739,082,5, It is described in 908,810 and 7,112,665.
Other herbicide tolerant plants can also be the herbicide to suppression hydroxyphenylpyruvic acid dioxygenase (HPPD) There is the plant of toleration.Hydroxyphenylpyruvic acid dioxygenase is that catalysis Single-chip microcomputer (HPP) changes into the anti-of 2,5-dihydroxy-.alpha.-toluic acid. The enzyme answered.HPPD inhibitor is had the gene of the plant available code naturally occurring resistance HPPD enzyme of toleration or with compiling The gene of the HPPD enzyme of code sudden change converts, as described in WO96/38567, WO99/24585 and WO99/24586.To HPPD Although the toleration of inhibitor also can be by inhibited but remain to natural HPPD enzyme by some HPPD inhibitor of coding The gene pairs plant of the enzyme enough forming 2,5-dihydroxy-.alpha.-toluic acid. converts and obtains.Described plant and gene are at WO99/34008 and WO02/ It is described in 36787.Plant to the toleration of HPPD inhibitor in addition to the gene with coding HPPD toleration enzyme, it is possible to by with Encode the gene-transformed plant of prephenate dehydrogenase and improve, as described in WO2004/024928.
Other herbicide tolerant plants also has the plant to acetolactate synthase (ALS) inhibitor with toleration. Known ALS inhibitor includes, such as sulfonylureas, imidazolone, triazolo pyrimidine class, pyrimidine radicals oxygen (sulfur) yl benzoic acid esters (pyrimidinyoxy (thio) benzoates) and/or Herbicidal sulphonylamino carbonyl triazole quinoline ketone (sulfonylaminocarbonyltriazolinone) herbicide.Known ALS enzyme (also referred to as acetohydroxy acid synthase, AHAS) In different sudden changes give different herbicides and herbicide group tolerations, as such as at Tranel and Wright(2002, Weed Science50:700-712) institute and in United States Patent (USP) No.5,605,011,5,378,824,5,141,870 and 5,013,659 State.The preparation of sulfonylureas tolerant plants and imidazolinone-tolerant plant United States Patent (USP) No.5,605,011,5,013, 659,5,141,870,5,767,361,5,731,180,5,304,732,4,761,373,5,331,107,5,928,937 and 5, 378,824；And international publication text WO96/33270 is described.Other imidazolinone-tolerant plant is such as WO2004/040012、WO2004/106529、WO2005/020673、WO2005/093093、WO2006/007373、WO2006/ 015376, WO2006/024351 and WO2006/060634 is also described.Other sulfonylureas tolerant plants and miaow Oxazoline ketone tolerant plants is also described in such as WO07/024782.
Other plant to imidazolone and/or sulfonylureas with toleration can pass through mutation, the feelings existed at herbicide Carry out cell under condition to cultivate selection or mutagenic breeding and obtain, such as United States Patent (USP) 5, to Semen sojae atricolor, WO97/ in 084,082 In 41218 in rice, United States Patent (USP) 5,773,702 and WO99/057965 in Radix Betae, United States Patent (USP) 5,198,599 to Caulis et Folium Lactucae sativae Or the description in WO01/065922, Helianthi carried out.
The plant or the plant cultivars that process according to the present invention (are obtained by Plant Biotechnology rule such as genetic engineering ) can be also that the transgenic plant with insect-resistant, the i.e. invasion and attack to some targeted insect have the plant of resistance.Described plant Thing can be by genetic transformation or by selecting the plant of the sudden change containing the described insect-resistant of imparting to obtain.
" having the transgenic plant of insect-resistant " used herein includes including encoding following albumen containing at least one Any plant of the transgenic of coded sequence:
1) insecticidal crystal protein of Bacillus thuringiensis (Bacillus thuringiensis) or its insecticidal part, such as Crickmore et al. (1998, Microbiology and Molecular Biology Reviews, 62:807-813) is in Soviet Union The name of cloud gold bacillus toxin is listed, the insecticidal crystal protein that updated by Crickmore et al. (2005) (online: http: // Or its insecticidal part, such as Cry protide www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/) The albumen of Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Aa or Cry3Bb or its insecticidal part；Or
2) there is in the presence of the another kind of crystalline protein or one part of Bacillus thuringiensis the Su Yun gold bar of insecticidal activity Bacterium crystalline protein or one part, the binary toxin (Moellenbeck etc. being such as made up of Cry34 and Cry35 crystalline protein People, 2001, Nat.Biotechnol.19,668-72;Schnepf et al. 2006, Applied Environm.Microbiol.71,1765-1774)；Or
3) the hybrid insecticidal proteins of part of the different insecticidal crystal proteins containing Bacillus thuringiensis, such as above-mentioned 1) albumen Hybrid or above-mentioned 2) the hybrid of albumen, the Cry1A.105 albumen (WO2007/ such as prepared by MON98034 Semen Maydis strain 027777)；Or
4) above-mentioned A1)-A3) in any one, wherein for obtain insecticidal activity higher to target insect species and/ Or extend the scope of the target insect species acted on and/or owing to introducing changing in coding DNA in clone or conversion process Become and by some aminoacid, the albumen of particularly 1-10 aminoacid another kind aminoacid replacement, such as MON863 or Cry3Bb1 albumen in MON88017 Semen Maydis strain or the Cry3A albumen in MIR604 Semen Maydis strain；
5) Bacillus thuringiensis or the parasite killing secretory protein of Bacillus cercus (Bacillus cereus) or its parasite killing portion Point, such as nutritive insecticidal albumen (VIP) listed in following Internet address hffp: http://www.lifesci.sussex.ac.uk/ The albumen of home/Neil_Crickmore/Bt/vip.html, such as VIP3Aa protide；Or
6) there is in the presence of the another kind of secretory protein of Bacillus thuringiensis or Bacillus cercus the Soviet Union of insecticidal activity Cloud gold bacillus or the secretory protein of Bacillus cercus, the binary toxin (WO94/ being such as made up of VIP1A and VIP2A albumen 21795)；Or
7) contain from Bacillus thuringiensis or the hybrid insecticidal proteins of the part of the different secretory proteins of Bacillus cercus, The most above-mentioned 1) hybrid of albumen or above-mentioned 2) the hybrid of albumen；Or
8) in above-mentioned 1)-3) any one, wherein for obtain insecticidal activity higher to target insect species and/or Extend the scope of the target insect species acted on and/or owing to introducing the change in coding DNA in clone or conversion process (the most still encoding insecticidal proteins) simultaneously and by some aminoacid, particularly 1-10 the aminoacid egg of another kind aminoacid replacement In vain, such as the VIP3Aa albumen in COT102 Semen Maydis strain.
Certainly, the transgenic plant with insect-resistant used herein also includes containing encoding above-mentioned 1-8 apoplexy due to endogenous wind any Any plant of the combination of the gene of the albumen of item.In one embodiment, the plant with insect-resistant comprises more than one The transgenic of the albumen encoding above-mentioned 1-8 apoplexy due to endogenous wind any one planted, thus when using for different target caste not Scope with the target insect species that extension during albumen is acted on；Or by using, same target caste is had parasite killing Activity but have different model of action be such as bound to insecticide different receptor binding sites different albumen come The generation of the insect-resistant of delay plant.
The plant or the plant cultivars that process according to the present invention (are obtained by Plant Biotechnology rule such as genetic engineering ) also abiotic stress can be had toleration.Described plant can be by genetic transformation or described by selecting containing giving The plant of the sudden change of stress resistance and obtain.Useful especially stress tolerant plants includes:
A. contain and can reduce the expression of many adenosine diphosphate-ribose polymerase (PARP) genes in plant cell or plant And/or the plant of the transgenic of its activity, as described in WO00/04173 or EP04077984.5 or EP06009836.5.
B. containing be improved stress tolerance the expression that can reduce PARG encoding gene in plant or plant cell and/or The plant of the transgenic of its activity, such as described in WO2004/090140.
C. containing the Plant functional to nicotinamide adenine dinucleotide salvage route being improved stress tolerance Enzyme carries out the plant of the transgenic encoded, and described Plant functional enzyme includes nicotinamidase, nicotinic acid phosphoribosyl transferase, cigarette Acid mononucleotide adenine transferring enzyme, nicotinamide adenine dinucleotide synzyme or nicotinamide phosphoribosyl transferase, example As described in EP04077624.7 or WO2006/133827 or PCT/EP07/002433.
The plant or the plant cultivars that process according to the present invention (are obtained by Plant Biotechnology rule such as genetic engineering ) can also show the change of the quantity of harvested products, quality and/or bin stability, and/or the concrete composition of harvested products The change of character, such as:
1) transgenic plant of synthesis modification starch, the physicochemical properties of this modified starch, particularly amylose contain Amount or amylose/amylopectin ratios, degree of branching, average chain length, side chain distribution, viscosity, gel strength, starch granularity And/or morphology of starch grain, compared with the synthetic starch in wild type plant cell or plant, there occurs change, thus it can be suitableeer In concrete application.The transgenic plant of described synthesis modification starch such as EP0571427, WO95/04826, EP0719338, WO96/15248、WO96/19581、WO96/27674、WO97/11188、WO97/26362、WO97/32985、WO97/42328、 WO97/44472、WO97/45545、WO98/27212、WO98/40503、WO99/58688、WO99/58690、WO99/58654、 WO00/08184、WO00/08185、WO00/08175、WO00/28052、WO00/77229、WO01/12782、WO01/12826、 WO02/101059、WO03/071860、WO2004/056999、WO2005/030942、WO2005/030941、WO2005/ 095632、WO2005/095617、WO2005/095619、WO2005/095618、WO2005/123927、WO2006/018319、 WO2006/103107、WO2006/108702、WO2007/009823、WO00/22140、WO2006/063862、WO2006/ 072603、WO02/034923、EP06090134.5、EP06090228.5、EP06090227.7、EP07090007.1、 EP07090009.7、WO01/14569、WO02/79410、WO03/33540、WO2004/078983、WO01/19975、WO95/ 26407、WO96/34968、WO98/20145、WO99/12950、WO99/66050、WO99/53072、US6734341、WO00/ 11192、WO98/22604、WO98/32326、WO01/98509、WO01/98509、WO2005/002359、US5824790、 US6013861, WO94/04693, WO94/09144, WO94/11520, WO95/35026, WO97/20936 are disclosed,
2) synthesis non-starch carbohydrate polymer or synthesis tool compared with the wild-type plant not carrying out genetic modification The transgenic plant of the non-starch carbohydrate polymer of the character changed.Example has generation polyfructosan (polyfructose), especially inulin-type and the plant of fructan-type polyfructosan, as EP0663956, WO96/01904, Disclosed in WO96/21023, WO98/39460 and WO99/24593；Produce α-Isosorbide-5-Nitrae-glucosan plant, as WO95/31553, US2002031826, US6284479, US5712107, WO97/47806, WO97/47807, WO97/47808 and WO00/14249 Disclosed in；Producing α-1, the plant of 6 branched alphas-Isosorbide-5-Nitrae-glucosan, as disclosed in WO00/73422；Produce the plant of alternan, As disclosed in WO00/47727, EP06077301.7, US5908975 and EP0728213,
3) produce hyaluronan (hyaluronan) transgenic plant, as such as WO2006/032538, Disclosed in WO2007/039314, WO2007/039315, WO2007/039316, JP2006304779 and WO2005/012529.
The plant or the plant cultivars that process according to the present invention (can be obtained by Plant Biotechnology rule such as genetic engineering ) can be also the plant of the fiber properties with change, such as vegetable lamb.Described plant can be by genetic transformation or by choosing Selecting the plant of the sudden change containing the fiber properties that can give described change and obtain, described plant includes:
A) plant of the cellulose synthase gene changed containing form, such as vegetable lamb, such as institute in WO98/00549 State
B) plant of rsw2 or the rsw3 homologous nucleic acid changed containing form, such as vegetable lamb, such as WO2004/053219 Described in
C) having the plant that the Sucrose Phosphate Synthase of enhancing is expressed, such as vegetable lamb, such as institute in WO01/17333 State
D) having the plant of the Sucrose synthesis expression of enzymes of enhancing, such as vegetable lamb, as described in WO02/45485
E) wherein the timing of fibrocyte base portion plasmodesmata gate changes such as by fiber selectivity β 1,3-Portugal The plant of the downward of dextranase, such as vegetable lamb, as described in WO2005/017157
F) have that reactivity changes such as (includes nodC and chitin by N-acetyl glucosamine transferase gene Matter synthase gene) express fiber plant, such as vegetable lamb, as described in WO2006/136351
The plant or the plant cultivars that process according to the present invention (can be obtained by Plant Biotechnology rule such as genetic engineering ) can be also the plant of the oily distribution characteristics with change, such as Brassica campestris L or relevant Caulis et Folium Brassicae campestris carex.Described plant can be led to Cross genetic transformation or by selecting the plant of the sudden change containing the fiber properties that can give described change to obtain, described plant bag Include:
A) plant of the oil with high gas oil ratio content is produced, such as rapeseed plant, such as such as US5,969,169, US5, Described in 840,946 or US6,323,392 or US6,063,947
B) plant of the oil with low linolenic is produced, such as rapeseed plant, such as US6,270828, US6,169, Described in 190 or US5,965,755
C) plant of the oil with low saturated fatty acid content is produced, such as rapeseed plant, such as such as US patent 5,434, Described in 283
Can be the combination containing transformation plant or transformation plant according to the useful especially transgenic plant of present invention process And be non-control state (non-regulated status) application theme plant, this application is to U.S.'s agriculture in the U.S. Industry portion (USDA) animals and plants sanitary inspection administration (Animal and Plant Health Inspection Service, APHIS) Proposing, the most described application has authorized or the most undecided the most.The most all can be from APHIS(4700River Road Riverdale, MD20737, U.S.) place is such as from its website (URL http://www.aphis.usda.gov/brs/ Not_reg.html) this information is easily obtained on.In the submission day of the application, APHIS is pendent or APHIS awards The non-control state application of power is those listed by table B, containing following information in table B:
-application: No. ID of application.Such as obtained by this application number from APHIS website at APHIS Single application documents in the technology to transformation plant can be found to describe.These are described in this and include in herein with way of reference.
The prolongation (extension of petition) of-application: the original application targeted with reference to extending request.
-mechanism: submit the title of the entity of this application to.
-by control product: corresponding plants kind.
-transgenic phenotypes: given the character of plant by transformation plant
-transformation plant or convert system: the title of the targeted strain of non-control status request (be sometimes also designated as be).
APHIS file: APHIS announce relevant this application various files and can to APHIS request various files.
Some other useful especially plant combined containing single transformation plant or transformation plant, is listed in various countries Or area administrative organization data base in (for example, see http://gmoinfo.jrc.it/gmp_browse.aspx and Http:// www.agbios.com/dbase.php).
Other special transgenic plant includes containing the plant being in neutral or vantage point the transgenic of agronomy, In patent disclosure text as listed by table C described in an arbitrary piece.
It is listed in Table A while there is the example nonexhaustive of the plant of above-mentioned characteristic
Can be the combination containing transformation plant or transformation plant according to the useful especially transgenic plant of present invention process Plant, described plant be listed in the data base of such as various countries or area administrative organization (see for example http: // Gmoinfo.jrc.it/gmp_browse.aspx and http://www.agbios.com/dbase.php).
Can be listed in table B together with its trade (brand) name according to the useful especially transgenic plant that the present invention processes.
Table B
It is neutral or useful position that some other special transgenic rice plant includes being in agronomy containing at least one The plant of transgenic, as shown in table c.
Table C2
In one extremely particularly embodiment, describe a kind of therapeutic or preventative preventing and treating plant or the plant of crop Pathogen and/or microorganism and/or the method for insect, the method include using in the following manner ((A) and (B)) or ((A) and (B) and (C)) conjugate: be applied to wherein activity expression mechanism and repaiied corresponding to a kind of heredity in form A, B or C The decorations seed of plant, plant propagation material, plant or fruit.
In one extremely particularly embodiment, describe a kind of therapeutic or preventative preventing and treating plant or the plant of crop Pathogen and/or microorganism and/or the method for insect, the method include using in the following manner ((A) and (B)) or ((A) and (B) and (C)) conjugate: be applied to wherein activity expression mechanism corresponding to a kind of something lost in arbitrary form A, B or C Pass the seed of modified plant, plant propagation material, plant or fruit.
On the other hand, it is provided that a kind of compositions containing conjugate of the present invention.Preferably this sterilization and Pesticidal combination Containing the most acceptable additive, solvent, carrier, surfactant or filler.
Term " carrier " in the present invention represents natural or synthesis, organic or inorganic compound, active ingredient Thing (A), reactive compound (B) and reactive compound (C) were easier to use when this compound is combined or mixes, particularly imposed on Plant part.Therefore this carrier is the most inert and at least should be the most acceptable.This carrier can be solid or liquid.
Suitable solid carrier is as follows:
Such as ammonium salt, and natural rock stone powder such as Kaolin, clay, Talcum, Chalk, quartz, attapulgite, montmorillonite or silicon Diatomaceous earth, and silicon dioxide, aluminium oxide and the silicate of the Rock Powder such as polymolecularity of synthesis, petroleum paraffin, solid fertilizer, water, The preferred butanol of alcohols, organic solvent, mineral oil and vegetable oil and derivant thereof；
The suitable solid carrier of granule has: such as pulverize and the natural rock of classification, as calcite, marble, Pumex, Meerschaum, dolomite, and the inorganic and organic dust granule of synthesis；Organic substance (such as paper, sawdust, coconut husk, corn stalk and Nicotiana tabacum L. Bar) granule；
The gaseous diluent of liquefaction or carrier refer at normal temperatures and pressures for the liquid of gaseous state, such as aerosol spray, Such as halogenated hydrocarbons and butane, propane, nitrogen and carbon dioxide.
The binding agent that can use in the formulation has, such as carboxymethyl cellulose, natural and powder, granule or the glue of synthesis The polymer of emulsus, such as Radix Acaciae senegalis, polyvinyl alcohol, polyvinyl acetate, and natural phospholipid such as cephalin and lecithin, with And synthetic phospholipid.Other additive can be optionally modified mineral oil or vegetable oil and wax class.
Suitable filler has, such as water, polarity and nonpolar organic chemistry liquid, is selected from aromatic hydrocarbon and non- (if appropriate, it can also be to take for aromatic hydrocarbon (such as paraffinic, alkyl benzene, alkylnaphthalene, chlorobenzene), alcohols and polyhydric alcohol Generation, etherificate and/or esterification), ketone (such as acetone, Ketohexamethylene), ester (including fats and oils) and (gathering) ether, do not take Generation and substituted amine, amide, lactams (such as N-alkyl pyrrolidone) and lactone, sulfone and sulfoxide (such as dimethyl Asia Sulfone).
If filler used is water, it is also possible to use-case such as organic solvent makees secondary solvent.Suitable liquid solvent mainly has: Aromatic species, such as dimethylbenzene, toluene or alkylnaphthalene, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzene, vinyl chloride or dichloromethane, Aliphatic hydrocarbons such as hexamethylene or paraffinic, such as petroleum distillate, mineral oil and vegetable oil, alcohols such as butanol or ethylene glycol and Its ether and ester, ketone such as acetone, butanone, methyl iso-butyl ketone (MIBK) or Ketohexamethylene, intensive polar solvent such as dimethyl sulfoxide, and Water.
The present composition also can contain additional compound.Particularly, said composition also can contain surfactant.Surface Activating agent can be the mixed of a kind of ion-type or the emulsifying agent of nonionic, dispersant or wetting agent or described surfactant Compound.It can be mentioned that have such as polyacrylate, lignosulfonates, phenolsulfonate or naphthalene sulfonate, oxirane with Fatty alcohol or with fatty acid or with the condensation polymer of fatty amine, substituted phenol (particularly alkylphenol or aryl phenol), sulfo group Succinate salt, taurine derivatives (particularly taurine Arrcostab), polyoxyethylenated alcohol or the phosphate ester of phenol, polyhydric alcohol Fatty acid ester, and containing sulfate radical, the derivant of the described compound of sulfonate radical and phosphonate functional group, such as alkylaryl Polyglycol ether, alkylsulfonate, alkyl sulfate, arylsulphonate, protein hydrolyzate, lignin sulfite waste liquor and methyl Cellulose.When reactive compound and/or inert carrier are water insoluble and when used carrier agent (vector agent) is water, Typically must be present at least one surfactant.Preferred surfactant content can account for 5 weight %-40 weight % of compositions.
Suitably emulsifying agent and/or foaming agent has: such as nonionic and anion emulsifier, such as polyoxyethylene fatty acid Ester, polyoxyethylene aliphatic alcohol ether.Suitably dispersant is nonionic and/or ionic species, is selected from alcohol POE and/or POP Ether, acid and/or POP or POE ester, alkylaryl and/or POP or POE ether, fat and/or POP-POE adduct, POP and/or POE polyol derivative, POE and/or POP/ sorbitan or sugar adduct, alkyl or aryl sulfate, sulfonate and Phosphate or corresponding PO ether adduct.Additionally, suitably oligomer or polymer, such as based on vinyl monomer, acrylic acid, Individually EO and/or PO or its with such as (gather) alcohols or the combination of (gathering) amine.It is used as lignin and sulfnic acid derivatives thereof Biology, simple cellulose (simple cellulose) and modified cellulose, aromatic series and/or aliphatic sulfonic acid and and first thereof The adduct of aldehyde.Suitably dispersant is such as lignin sulfite waste liquor and methylcellulose.
Coloring agent, such as inorganic pigment such as ferrum oxide, titanium dioxide, Prussian blue (ferrocyanblue) can be used, With organic pigment such as alizarin dyes, azo dye and metallized phthalocyanine dye, and trace element such as ferrum, manganese, boron, copper, cobalt, molybdenum and zinc Salt.
Optionally, it is also possible to include other additional compound, such as protective colloid, binding agent, thickening agent, thixotropic agent, Penetrating agent, stabilizer, chelating agen.More generally, described reactive compound can preparation technique and any solid or liquid routinely Body additives combines.
Generally, the compositions of the present invention can contain 0.05-99 weight %, preferred 1-70 weight %, most preferably 10-50 weight The reactive compound of amount %.
The conjugate of the present invention or compositions can with itself, its dosage form or the type of service thus prepared use, Such as aerosol, microcapsule suspending agent, cold mist agent (cold fogging concentrate), thermal fog, microcapsulated granule, particulate Agent, seed treatment suspending agent, ready to use solution, powder, cream, oil-in-water emulsion, water-in-oil emulsion, big granule, microgranule Agent, oil-dispersing property powder, oil suspending agent, oil preparation, foam (froths), paste, seed coat agent, colloidal suspending agent (suspending agent), outstanding breast are dense Contracting agent, aqueous solvent, suspending agent, soluble powder, granule, water-soluble granular formulation or tablet, seed treatment water solube powder, Wettable powder, the dipping natural and synthetic material of reactive compound, seed polymeric material and involucrum microcapsule, and The cold mist of ULV and hot mist preparation, (compression) gas, foaming agent, stick, dry seeds process powder, seed treatment solution, super-low capacity The amount liquor of (ULV), suspending agent, water-dispersible granules or the tablet of ultra-low volume (ULV), wet seed treatment water dispersible Powder.
Described preparation is by filling out reactive compound or active agent combinations with conventional additives such as routine Fill agent and solvent or diluent, emulsifying agent, dispersant and/or binding agent or fixative, wetting agent, waterproofing agent mixing with A kind of known way is prepared, if appropriate, add drier and UV stabilizer, coloring agent, pigment, defoamer, preservative, Secondary thickening agent (secondary thicknener), binding agent, gibberellins and water and other processing aid.
Described compositions not only includes being applied to pending plant or kind by suitable equipment (such as spraying or dusting device) Sub i.e. uses compositions, and includes the dense commercial composite must being diluted before being applied to crop.
To the preventing and treating of the infringement phytopathogen of plant and/or microorganism and/or insect mainly by protecting with crop after Seedling Protect agent process soil and aboveground vegetation part is carried out.In view of crop protection agents, environment and human and animal's health may be produced Impact, just make great efforts to reduce the amount of used reactive compound.
Active agent combinations of the present invention can using its commercial preparation and the type of service prepared by described preparation as with Other activity compound mixture use, other reactive compound described such as insecticide, attractant, chemosterilant, bactericide, Acaricide, nematicide, antifungal, growth regulatory substance, herbicide, safener, fertilizer or semiochemical.
With active agent combinations of the present invention, the process of plant and plant part is directly carried out with conventional treatment method Or carrying out by acting on its environment, habitat or storage areas, described conventional treatment method is such as irrigated (perfusion), is dripped Fill, spray, vaporize (vaporizing), atomization (atomizing), broadcast sowing, dust, foam, be coated with (spreading-on) and Powder, seed treatment solution, seed treatment water-soluble powder, wet seed treatment water soluble powder is processed as dry seeds End；Or by crust, in the case of propagating materials, especially in the case of seed, also by dry-cure, wet process, liquid Body processes, one or more layers coating is carried out.Additionally, also by the mensuration reactive compound of using of super-low capacity, or by activation Compound preparation or reactive compound itself inject in soil.
The rate of application of described conjugate can be according to the concrete activity such as used in type, agrotype, described conjugate Compound, the type (if appropriate) of plant propagation material and change, but the reactive compound in described conjugate should be able to be made Reaching to provide the effective dose of the activity (such as disease or Pest control) of required enhancing, it can be determined by test.
The processing method of the present invention additionally provide compound (A) and (B) by simultaneously, individually or in succession in the way of use.
In processing method of the present invention, conventional use of active compound doses/rate of application generally and is advantageously
-foliar treatment: 0.1 to 10,000g/ha(hectare), preferably 10 to 1,000g/ha, more preferably 25 to 300g/ha Compound (A)；The compound (B) of 0.1 to 10,000g/ha, preferably 10 to 1,000g/ha, more preferably 50 to 300g/ha；0.1 Compound (C) to 10,000g/ha, preferably 10 to 1,000g/ha, more preferably 50 to 300g/ha；Use in perfusion or drip irrigation In the case of, especially when using inert base such as rock wool or or during perlite, dosage the most also can reduce；
-seed treatment: every double centner seed 2 to 200g, the compound (A) of the most every double centner seed 3-150g；Often Double centner seed 2 to 200g, the compound (B) of the most every double centner seed 3-150g；Every double centner seed 2 to 200g, excellent Select the compound (C) of every double centner seed 3-150g；
The compound (A) of-soil treatment: 0.1 to 10,000g/ha, preferably 1 to 5,000g/ha；0.1 to 10,000g/ The compound (B) of ha, preferably 1 to 5,000g/ha；The compound (C) of 0.1 to 10,000g/ha, preferably 1 to 5,000g/ha.
Referred herein go out the form of dosage only illustrative examples the most in the process of the present invention be given.Those skilled in the art know How road adjusts application dosage, in particular according to pending plant or the kind of crop.
Conjugate of the present invention is protected plant resistant insect in can be used to certain section of time range after protection processes and/or plants Thing pathogen and/or microorganism and/or insect.The time range that protective effect comes into force generally is held after processing plant with conjugate It is up to 200 days after continuous 1-28 days, preferred 1-14 days or process plant propagation material.
The processing method of the present invention can also be used for processing propagating materials such as tuber or rhizome, and seed, seedling or children Seedling graft and plant or phytograft.Treatment method can be additionally used in process root.The processing method of the present invention can also be used with In processing aboveground vegetation part, the trunk of paid close attention to plant, stem or stem, leaf, flower and fruit.
Another aspect of the present invention is a kind of to protect plant or the natural materials of animal origin or their form processing Method, described material take from natural life circulation；The method includes one compound (A), compound (B) and compound (C) conjugate is applied to described plant or the natural materials of animal origin or their form processing with cooperative effective quantity.
One preferred embodiment is a kind of natural materials protecting plant origin or the method for their form processing, institute State material and take from natural life circulation；The method includes a kind of compound (A), compound (B) and the conjugate of compound (C) Natural materials or their form processing of described plant origin it is applied to cooperative effective quantity.
Further preferred embodiment be a kind of protection fruit (preferably melonidum, drupe, berry and citrus fruit) or The method of their form processing, described fruit takes from natural life circulation；The method includes one compound (A), chemical combination The conjugate of thing (B) and compound (C) is applied to natural materials or their processing of described plant origin with cooperative effective quantity Form.
The present invention includes the method that one compound (A), compound (B) and compound (C) process seed simultaneously.This The bright method also including that one compound (A), compound (B) and compound (C) process seed respectively.
The present invention also includes the seed that one had processed simultaneously with compound (A), compound (B) and compound (C).This Invention also includes the seed that one had processed respectively with compound (A), compound (B) and compound (C).For latter kind Son, effective ingredient can be applied in discrete layer.These layers can optionally be separated by other layer comprising or not comprising effective ingredient.
The conjugate of the present invention and/or compositions are particularly suitable for processing seed.By insect and/or phytopathogen and/or The major part infringement to cultigen that microorganism and/or insect cause is by the seed during infecting storage with after sowing underground Seed and plant germination during and germinate after seed and occur.Owing to just root and bud growing plants is especially sensitive And the most a small amount of infringement all can cause the withered of whole plant, and therefore this stage is particularly critical.Therefore people are to passing through Plant in using suitable medicament protection seed and germinateing has sizable interest.
It has been people's length by processing plant seed pest control and/or phytopathogen and/or microorganism and/or insect Phase is known and be the theme updated.But, always have many to solve unsatisfactorily in the process of seed Problem.Therefore, it is intended that develop so protection seed and the method for germination plant, the method makes need not be after planting or plant Plant protection product is additionally used after germination.It also is intended to optimize the amount of institute's applying active substances, in order to protect seed as well as possible Do not make plant originally experience institute with germination plant resistant insect and/or phytopathogen and/or microorganism and/or the invasion and attack of insect Use the infringement of reactive compound.Particularly, the method for seed is processed also it is also contemplated that the intrinsic sterilization of transgenic plant and killing Worm characteristic, to reach seed and the best protection of germination plant by the minimal consumption of plant protection product.
Therefore, the invention particularly relates to a kind of protection seed and germination plant from insect and/or phytopathogen and/or Microorganism and/or the method infected of insect, the conjugate/compositions-treated of the wherein said seed present invention.Additionally, this Bright further relate to conjugate/compositions of the present invention for processing seed with protection seed and germination plant antagonism insect and/or plant Pathogen and/or microorganism and/or the purposes of insect.And, the invention still further relates to as obtaining antagonism insect and/or pathogenic Bacterium and/or microorganism and/or the protection of insect and the seed crossed by the conjugate/compositions-treated of the present invention.
One of advantages of the present invention is, due to the distinctive internal absorption characteristic of conjugate/compositions of the present invention, combines with these The process that thing/compositions is carried out not only protects seed itself to avoid insect and/or phytopathogen and/or microorganism and/or evil Worm encroaches on, and the plant being unearthed after protecting rudiment.Can save at seeding time in this way or soon to cultivation thing Directly process.
Another advantage is, compared with each single reactive compound, the sterilization of conjugate/compositions of the present invention and parasite killing are lived Property collaborative increase, this activity exceed the single all reactive compounds used activity add and.Make in this way to optimize The amount of used reactive compound is possibly realized.
Also being seen as advantage, the mixture of the present invention can be additionally used in the seed of the most following transgenic, its In can be expressed for insect and phytopathogen and/or microorganism and/or the protein of insect by the plant of this seed germination. By with seed described in chemicals treatment of the present invention, some insect and/or phytopathogen and/or microorganism and/or insect can Enough by such as expressing insecticidal proteins and controlled, and also it is surprising that use medicament of the present invention that the association added occurs With activity, this synergistic activity further increases the effect of the protective effect to pest attacks.
Medicament of the present invention is suitable to protect the seed of all types botanical variety having been described, and it is in agricultural, greenhouse In, in forestry, bar excute a law in, in gardening or vineyard.Particularly, this to be applicable to corn (such as Semen Tritici aestivi, Fructus Hordei Vulgaris, rye (Secale cereale L.), black Semen Tritici aestivi, foxtail millet, Herba bromi japonici, rice), Semen Maydis, Cotton Gossypii, Semen sojae atricolor, Rhizoma Solani tuber osi, Helianthi, Kidney bean, coffee, Radix Betae (such as sugar beet, leaf Garden beet and fodder beet), Semen arachidis hypogaeae, Brassica campestris L, Semen Brassicae campestris, Semen Papaveris, Fructus Canarii albi, Cortex cocois radicis, cocoa, Caulis Sacchari sinensis or the seed of Nicotiana tabacum L..This Bright conjugate/compositions is also suitably for processing foregoing fruit bearing plant and vegetable (such as Fructus Lycopersici esculenti, Fructus Cucumidis sativi, Bulbus Allii Cepae and lettuce Lettuce), lawn, meadow and the seed of ornamental plant.Particularly importantly to Semen Tritici aestivi, Fructus Hordei Vulgaris, rye (Secale cereale L.), black Semen Tritici aestivi, Herba bromi japonici, Semen Maydis, Rice, Semen sojae atricolor, Cotton Gossypii, Brassica campestris L, the process of seed of Semen Brassicae campestris.
As it was previously stated, by the conjugate/compositions of the present invention process particular importance to transgenic seed.This is applicable to lead to The often plant seed containing at least one following heterologous gene, the control of described heterologous gene has the polypeptide of specific insecticidal properties Express.Heterologous gene in transgenic seed can derive from microorganism such as bacillus (Bacillus), root nodule bacteria (Rhizobium), pseudomonas (Pseudomonas), Serratia (Serratia), trichoderma (Trichoderma), Clavibacter, Paraglomus (Glomus) or Gliocladium (Gliocladium).Instant invention is especially suited for processing containing extremely The transgenic seed of few a kind of following heterologous gene, described heterologous gene derives from Bacillus, and its gene outcome shows To European corn borer and/or the activity of corn root leaf A (western corn rootworm).Particularly preferred being derived from is revived The heterologous gene of cloud gold bacillus.
In the context of the present invention, the conjugate/compositions of the present invention individually or is applied to seed with suitable dosage form. Seed is preferably processed when seed is stable enough to be without prejudice during processing.Process to seed generally can adopted Any time received between sowing is carried out.Conventional use of seed is for separate and to have removed meat Honoka from plant The seed of sequence, shell, stem, pod, fine hair or sarcocarp.Use seed be gathered, purify and be dried to moisture Seed less than 15% w/w.Or, it be also possible to use and process, with water, the seed being dried the most again after drying.
Generally it must be noted that be applied to the conjugate/compositions of the present invention of seed and/or other adds during seed treatment The amount adding agent should be chosen as the germination without compromising on seed and without compromising on emerged plants.Especially to when using with certain amount The reactive compound of phytotoxic effect can be shown.
Conjugate/the compositions of the present invention can directly be used, and does not i.e. contain additional compound and is not diluted.Generally Preferably conjugate/the compositions of the present invention is applied to seed with the form of dosage forms.Dosage forms for seed treatment It is known to a person skilled in the art with method and is described in such as documents below: US4,272,417A, US4, 245,432A、US4,808,430A、US5,876,739A、US2003/0176428A1、WO2002/080675A1、WO2002/ 028186A2。
Active agent combinations that can be used according to the invention and compositions can change into conventional Seed dressing formulations, the most molten Liquid, Emulsion, suspending agent, powder, foam, serosity or other seed coating material and ULV preparation.
Described preparation is by mixing reactive compound or active agent combinations in a known way with conventional additives Preparation, described conventional additives such as conventional fillers and solvent or diluent, coloring agent, wetting agent, dispersant, emulsifying agent, Defoamer, preservative, secondary thickening agent, binding agent, gibberellins and optional water.
May be present in the Suitable colouring agents in Seed dressing formulations of the present invention to include all being conventionally used for described purpose coloring agent.Both The pigment being slightly soluble in water can be used, it is possible to use be dissolved in the dyestuff of water.The example that can be mentioned that include known entitled rhodamine B, C.I. pigment red 122 and the coloring agent of C.I. solvent red 1.
May be present in the Suitable humectants in Seed dressing formulations of the present invention to include promoting moistening and being conventionally used for activity agrochemical thing All substances in matter preparation.Preferably use alkylnaphthalene-sulfonate, such as diisopropyl or diisobutyl naphthalene-sulfonate.
May be present in the suitable dispersant in Seed dressing formulations of the present invention and/or emulsifying agent includes the active agriculture that is outlined above Change all non-ionic, anion and the dispersant of cation conventional in substance preparation.
May be present in the suitable defoamer in Seed dressing formulations of the present invention and be included in institute conventional in activity agrochemical substance preparation There is the material that can suppress foam.Preferably use organic silicon defoamer and magnesium stearate.
May be present in the suitable preservatives in Seed dressing formulations of the present invention to include to make in agrochemical composition for described purpose All substances.By way of example, there can be mentioned Dichlorophenol and benzyl alcohol hemiformal.
May be present in the suitable secondary thickening agent in Seed dressing formulations of the present invention to include to combine in agrochemical for described purpose The all substances used in thing.The most suitably have cellulose derivative, acrylic acid derivative, xanthan gum, modified clay and Aerosil 200.
May be present in the suitable binding agent in Seed dressing formulations of the present invention be included in seed seed dressing in spendable all often Rule binding agent.That preferably mentions has polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose.
May be present in the suitable gibberellins in Seed dressing formulations of the present invention and preferably include gibberellins A1, A3(=gibberellin), A4 and A7, special Not preferably gibberellin A 3 (=gibberellin).The gibberellins of formula II is known, and the nomenclature of gibberellins can be at document mentioned below (see R.Wegler " Chemie der Pflanzenschutz-and Volume 2, Springer Verlag, Berlin-Heidelberg-New York, 1970, the 401-412 page) in find.
With the Seed dressing formulations of the present invention or by adding the suitable mixing apparatus of water preparation prepared therefrom process seed Including all mixing apparatus that can be conventionally used for seed dressing.The concrete grammar used during seed dressing include introducing seed blender, general Add with concrete requirement after Seed dressing formulations itself or water in advance dilution and carry out mixing until preparation is evenly distributed on seed On.Optionally, operation then it is dried.
In material protection, the material of the present invention can be used for safeguard industries material from bad mushroom and/or microorganism Infect and damage.
In the present invention, the implication of industrial materials is interpreted as Manufactured nonliving material in industry.Such as, treat By the active substance of the present invention protect against microorganism change or infringement industrial materials can be binding agent, sizing material, paper and Sheet material, fabric, carpet, leather, timber, coating and plastic, cooling lubricant (cooling lubricant) and other can By microbial infection or the material of infringement.Such as can be cooled down by the production part of appliance of the breeding infringement of mushroom and/or microorganism Water loop, cooling and heating system, air-conditioning and ventilating system, also in the range of material to be protected.Within the scope of the present invention, may be used The preferred binding agent of industrial materials, sizing material, paper and sheet material, leather, timber, coating, cooling lubricant and the heat exchange fluid mentioned Body, particularly preferred timber.
The conjugate of the present invention can prevent unfavorable effect, such as rotten, variable color and decolouring or mouldy (molding).
The processing method of the present invention can be additionally used in protection and stores article from mushroom and the invasion and attack of microorganism.According to this Bright, term " storage article " is interpreted as referring to plant origin or the natural materials of animal origin and various form processing thereof, its Take from natural life circulate and need digital preservation.The storage article of that newly gather or form processing plant origin (are such as planted Thing or its part), such as stem, leaf, tuber, seed, fruit or grain, protection can be obtained, described form processing is such as pre-dried , moistening, pulverize, grind, squeezing or the form baked and banked up with earth.The definition storing article also includes timber, thick timber shape Formula (such as construction timber, electric wire tower and fence) or finished commodities form (furniture being such as made up of timber or article). The storage article of animal origin have rawhide, leather, fur, hair etc..The conjugate of the present invention can prevent the generation of unfavorable effect, Such as rotten, variable color or mouldy.Preferably, " storage article " are interpreted as referring to the natural materials of plant origin and processing shape thereof Formula, more preferably fruit and form processing thereof, such as melonidum, drupe, berry and citrus fruit and form processing thereof.
In another preferred embodiment of the present invention, " storage article " are interpreted as referring to timber.The present invention kills Bacterium conjugate or compositions may further be used to resist the mushroom disease being prone to be grown on timber or in timber.Term " timber " means The timber of all seeds types and be intended for all types of converted productss of the described timber built, such as overall wood Material, high density timber, laminate and plywood.The method processing timber of the present invention essentially consists in so that it is with one or more The compound of the present invention or the compositions contact of the present invention；This includes the most directly using, spray, impregnate, inject or any its The method that it is suitable for.
In the disease of the plant that can be prevented and treated by the inventive method or crop, there can be mentioned:
Powdery mildew disease, such as:
Blumeria (Blumeria) disease, by such as grass family dlumeria graminis (Blumeria graminis) Cause；
Podosphaera (Podosphaera) disease, by such as white cross hair list softgel shell (Podosphaera Leucotricha) cause；
Sphaerotheca (Sphaerotheca) disease, by such as Flos Impatientis list softgel shell (Sphaerotheca fuliginea) Cause；
Uncinula (Uncinula) disease, is caused by such as Fructus Vitis viniferae snag shell (Uncinula necator)；
Rust diseases, such as
Glue Rust (Gymnosporangium) disease, by such as brown size rest fungus (Gymnosporangium Sabinae) cause；
Camel spore rust belongs to (Hemileia) disease, such as coffee rust (Hemileia vastatrix) cause；
Layer rest fungus (Phakopsora) disease, by such as Phakopsora pachyrhizi (Phakopsora pachyrhizi) and mountain horse Locust layer bacterium (Phakopsora meibomiae) causes；
Handle rest fungus (Puccinia) disease, by such as Puccinia recondita (Puccinia recondita) and puccinia triticinia (Puccinia triticina) causes；
Uromyces (Uromyces) disease, by such as wart top uromyce (Uromyces appendiculatus) Cause；
Oomycete class disease, such as
Dish downy mildew (Bremia) disease, is caused by such as Caulis et Folium Lactucae sativae dish downy mildew (Bremia lactucae)；
Downy mildew (Peronospora) disease, by such as Semen Pisi sativi downy mildew (Peronospora pisi) and Cruciferae downy mildew (Peronospora brassicae) causes；
Phytophthora (Phytophthora) disease, is caused by such as phytophthora infestans (Phytophthora infestans)；
Axle downy mildew (Plasmopara) disease, is caused by the raw axle downy mildew (Plasmopara viticola) of such as Fructus Vitis viniferae；
False downy mildew (Pseudoperonospora) disease, by the false downy mildew (Pseudoperonospora of such as grass Humuli) cause with Pseudoperonospora cubensis (Pseudoperonospora cubensis)；
Rotten mould (Pythium) disease, is caused by such as Pythium ultimum (Pythium ultimum)；
Leaf spot, leaf spot blight and leaf blight disease, such as
Alternaria (Alternaria) disease, is caused by such as early blight rod method (Alternaria solani)；
Cercospora (Cercospora) disease, is caused by the raw tail spore (Cercospora beticola) of such as dish；
Cladosporium (Cladiosporium) disease, is drawn by such as yellow melon fruit fly (Cladiosporium cucumerinum) Rise；
Cochliobolus belongs to (Cochliobolus) disease, such as standing grain cochliobolus (Cochliobolus sativus) draw Rise；
(conidial form (conidiaform): Drechslera (Drechslera), Syn: long compacted spore is mould (Helminthosporium))；
Colletotrichum (Colletotrichum) disease, by such as bean anthrax bacteria (Colletotrichum Lindemuthianum) cause；
Cycloconium disease, is caused by such as Cycloconium oleaginum；
Between seat shell belong to (Diaporthe) disease, such as seat shell between mandarin orange (Diaporthe citri) cause；
Elsinoe (Elsinoe) disease, is caused by such as mandarin orange Elsinochrome (Elsinoe fawcettii)；
The long spore of dish belongs to (Gloeosporium) disease, by such as pleasing the long spore of colour disk (Gloeosporium laeticolor) Cause；
Small cluster shell belongs to (Glomerella) disease, such as GLOMERFLLA CINGULATA (Glomerella cingulata) cause；
Ball seat Pseudomonas (Guignardia) disease, is caused by such as Fructus Vitis viniferae Guignardia (Guignardia bidwelli)；
Leptosphaeria (Leptosphaeria) disease, by such as black shank bacterium (Leptosphaeria maculans) Cause；
Ruin greatly shell and belong to (Magnaporthe) disease, such as Pyricularia oryzae (Magnaporthe grisea) cause；
Mycosphaerella (Mycosphaerella) disease, by such as standing grain green-ball chamber bacterium (Mycosphaerella Graminicola) cause with Fructus Musae secret note leaf spot fungi (Mycosphaeralla fijiensis)；
Phaeosphaeria disease, is caused by such as wheat glume blotch bacterium (Phaeosphaeria nodorum)；
Nuclear cavity Pseudomonas (Pyrenophora) disease, is caused by such as justifying nuclear cavity bacteria (Pyrenophora teres)；
Ramularia (Ramularia) disease, is caused by such as Ramularia collo-cygni；
Beak genus (Rhynchosporium) disease, is drawn by such as rye (Secale cereale L.) beak spore (Rhynchosporium secalis) Rise；
Pin spore belongs to (Septoria) disease, such as Septoria apii (Septoria apii) cause；
Core coral Pseudomonas (Typhula) disease, is caused by such as meat spore core coral bacterium (Typhula incarnata)；
Venturia (Venturia) disease, is caused by such as apple black star bacteria (Venturia inaequalis)；
Root and stem disease evil, such as:
Corticium (Corticium) disease, is caused by such as Corticium graminearum；
Fusarium (Fusarium) disease, is caused by such as point fusarium (Fusarium oxysporum)；
Gaeumannomyces (Gaeumannomyces) disease, by such as Semen Tritici aestivi top softgel shell bacterium (Gaeumannomyces Graminis) cause；
Rhizoctonia (Rhizoctonia) disease, is caused by such as Rhizoctonia solani Kuhn (Rhizoctonia solani)；
Oculimacula(Tapesia) disease, is caused by such as Oculimacula Tapesia acuformis；
Thiclaviopsis (Thielaviopsis) disease, by such as thielaviopsis sp (Thielaviopsis basicola) Cause；
The spadix caused by following pathogen and panicled spike (including corncob) disease, such as:
Alternaria disease, is caused by such as Alternaria (Alternaria spp.)；
Aspergillus (Aspergillus) disease, is caused by such as Aspergillus flavus (Aspergillus flavus)；
Cladosporium (Cladosporium) disease, is caused by such as Cladiosporium cladosporioides；
Claviceps (Claviceps) strain, such as Clavicipitaceae (Claviceps purpurea)；
Fusarium disease, is caused by such as yellow fusarium (Fusarium culmorum)；
Gibberella (Gibberella) disease, is caused by such as Gibberella zeae (Gibberella zeae)；
Little setting-out shell belongs to (Monographella) disease, by such as avenging rotten little setting-out shell (Monographella Nivalis) cause；
Smut and raw meat black powder fringe disease disease, such as:
Axle Ustilago (Sphacelotheca) disease, by such as Sporisorium reilianum (Sphacelotheca Reiliana) cause；
Tilletia (Tilletia) disease, is caused by such as Tilletia caries (Tilletia caries)；
Urocystis (Urocystis) disease, is caused by the most hidden bar smut (Urocystis occulta)；
Smut (Ustilago) disease, is caused by such as naked smut (Ustilago nuda)；
Fruit rot and mildew, such as:
Aspergillus disease, is caused by such as Aspergillus flavus；
Botrytis (Botrytis) disease, is caused by such as Botrytis cinerea (Botrytis cinerea)；
Penicillium (Penicillium) disease, by such as penicillium expansum (Penicillium expansum) and Penicillium purpurogenum causes；
Sclerotinia (Sclerotinia) disease, is caused by such as sclerotinite (Sclerotinia sclerotiorum)；
Verticillium (Verticillium) disease, is drawn by the such as Huang Verticillium (Verticillium alboatrum) that withers Rise；
It is that kind pass and soil passes rots, go rotten, wilt, rot and damping-off disease,
Alternaria (Alternaria-Arten), by the raw rod method (Alternaria of such as Semen Brassicae Campestris Brassicicola) cause,
Aphanomyces (Aphanomyces-Arten), is drawn by such as root-rot silk capsule mould (Aphanomyces euteiches) Rise,
Ascochyta (Ascochyta-Arten), is caused by such as Ascochyta lentis；
Aspergillus (Aspergillus-Arten), is caused by such as Aspergillus flavus (Aspergillus flavus),
Cladosporium (Cladosporium-Arten), is caused by such as draft branch spore (Cladosporium herbarum),
Cochliobolus belongs to (Cochliobolus-Arten), by such as standing grain cochliobolus (Cochliobolus sativus) Cause,
(conidial form (konidienform): Drechslera, Bipolaris Syn: long compacted spore is mould)；
Colletotrichum (Colletotrichum-Arten), by such as hair core anthrax (Colletotrichum Coccodes) cause；
Fusarium (Fusarium-Arten), is caused by such as yellow fusarium (Fusarium culmorum),
Gibberella (Gibberella-Arten), is caused by such as Gibberella zeae (Gibberella zeae),
Shell ball spore belongs to (Macrophomina-Arten), by such as Kidney bean shell ball spore (Macrophomina Phaseolina) cause,
Monographella-Arten, is caused by such as avenging rotten bright shuttle spore genus (Monographella nivalis),
Penicillium (Penicillium-Arten), is caused by such as penicillium expansum (Penicillium expansum),
Phoma (Phoma-Arten), is caused by the most black shin Phoma sp (Phoma lingam),
Phomopsis (Phomopsis-Arten), is caused by such as Semen sojae atricolor Phomopsis (Phomopsis sojae),
Phytophthora (Phytophthora Arten), is caused by such as Phytophthora cactorum (Phytophthora cactorum),
Nuclear cavity Pseudomonas (Pyrenophora-Arten), is drawn by such as wheat and barley nuclear cavity bacteria (Pyrenophora graminea) Rise,
Pyricularia Sacc. (Pyricularia-Arten), is caused by such as Magnaporthe grisea (Pyricularia oryzae),
Rotten mould (Pythium-Arten), is caused by such as Pythium ultimum (Pythium ultimum)；
Rhizoctonia (Rhizoctonia-Arten), is caused by such as Rhizoctonia solani Kuhn (Rhizoctonia solani),
Rhizopus (Rhizopus-Arten), is caused by such as Rhizopus oryzae (Rhizopus oryzae),
Bulbil belongs to (Sclerotium-Arten), such as Sclerotium rolfsii (Sclerotium rolfsii) cause,
Septoria (Septoria-Arten), is caused by such as Septoria musiva (Septoria nodorum),
Core coral Pseudomonas (Typhula-Arten), is caused by such as meat spore core coral bacterium (Typhula incarnata),
Verticillium Nees (Verticillium), is caused by such as verticillium dahliae (Verticillium dahliae)；
Ulcer, witches' broom and disease disease of dying ack, such as:
Nectria (Nectria) disease, is caused by such as Fructus Mali pumilae shuttle scar pathogenic bacteria (Nectria galligena)；
Blight disease, such as:
Chain sclerotinia sclerotiorum belongs to (Monilinia) disease, such as drupe chain sclerotinia sclerotiorum (Monilinia laxa) cause；
Leaf blotch exanthema or leaf-curl disease, including flower and the distortion of fruit, such as:
Exoascus (Taphrina) disease, is caused by such as Fructus Persicae external capsule bacterium (Taphrina deformans)；
The degeneration disease of xylophyta, such as:
Esca disease, by such as Phaeomoniella clamydospora and Phaeoacremonium aleophilum Cause with Fomitiporia mediterranea;
Flower and the disease of seed, such as:
Botrytis disease, is caused by such as Botrytis cinerea；
Tuber disease, such as:
Rhizoctonia disease, is caused by such as Rhizoctonia solani Kuhn；
The long mould disease of compacted spore, is caused by the such as compacted spore of eggplant length (Helminthosporium solani).
The disease caused by following bacterial organism,
Yellow unit cell (Xanthomanas) strain, such as xanthomonas campestris Oryza sativa L. pvs oryzae and oryzicola (Xanthomonas Campestris pv.Oryzae)；
False unit cell (Pseudomonas) strain, such as pseudomonas syringae Fructus Cucumidis sativi pvs oryzae and oryzicola (Pseudomonas Syringae pv.Lachrymans)；
Ou Wenshi (Erwinia) strain, such as, solve Erzvinia amylovora (Erwinia amylovora).
The compound of the present invention is preferred for preventing and treating following soybean diseases:
Leaf, stem top, soybean pod and the fungal disease of seed, such as:
Rod method leaf spot (Alternaria spec.atrans tenuissima), anthrax (Colletotrichum Gloeosporoides dematium var.truncatum), brown spot (Soybean Brown Spot stricture of vagina septoria musiva (Septoria Glycines)), tail spore leaf spot and leaf blight (Cercospora kikuchii (Cercospora kikuchii)), Choanephora leaf blight (choanephora leaf blight) (mould (Choanephora infundibulifera trispora of funnel hairpin (Syn.))), Fungi Imperfecti leaf spot (dactuliophora leaf spot) (Dactuliophora glycines), downy mildew (green soyabeans dew bacterium pathogenic bacteria (Peronospora manshurica)), Drechslera epidemic disease (Drechslera glycini), the frog Oculopathy (Germ To Soybean Frogeye Leaf Spot (Cercospora sojina)), linum plaque belong to leaf spot (Leptosphaerulina leaf Spot) (Herba Trifolii Pratentis helminthosporium leaf spot bacterium (Leptosphaerulina trifolii)), phyllosticta leaf spot (Phyllostica Leaf spot) (Semen sojae atricolor grey scab bacterium (Phyllosticta sojaecola)), soybean pod and cane blight (Phomopsis Sojae), powdery mildew (scattered cross hair shell (Microsphaera diffusa)), YRENOCHAETA leaf spot (Pyrenochaeta Leaf spot) (Pyrenochaeta glycines), rhizoctonia epidemic disease, leaf blight and damping-off (Rhizoctonia solani Kuhn) on the ground, Rust (Phakopsora pachyrhizi, Herba podocarpii oxyphylli layer bacterium), shot hole (Semen sojae atricolor crust circle spore (Sphaceloma glycines)), the mould leaf of handle of crawling Rot (Stemphylium leaf blight) (handle spore of crawling mould (Stemphylium botryosum)), target spot (Target Spot) (Corynespora cassicola bacterium (Corynespora cassiicola))；
Root and the fungal disease of the lower portion of the stem, such as:
Black root rot (Caionectria bacterium (Calonectria crotalariae)), charcoal rot (Kidney bean shell ball spore bacterium (Macrophomina phaseolina)), fusarium droop or wilting, root rot and pod and collar maize ear rot (point fusarium, straight Beak fusarium (Fusarium orthoceras), F.semitectum (Fusarium semitectum), Herba Equiseti Hiemalis fusarium (Fusarium Equiseti)), the mould root rot of lotus spore (the Mycoleptodiscus root rot) (mould (Mycoleptodiscus of water hyacinth spore Terrestris)), new red shell bacterium sick (Neocosmospora) (invades the new red shell bacterium (Neocosmopspora of arteries and veins Vasinfecta)), pod blight and cane blight (soybean stem ulcer bacteria (Diaporthe phaseolorum)), stem canker (Semen sojae atricolor north stem canker (Diaporthe phaseolorum var.caulivora)), phytophthora maize ear rot (big male phytophthora (Phytophthora megasperma)), brown stem rot (brown stem rot bacterium (Phialophora gregata)), rotten mould Sick (pythium rot) (melon and fruit corruption mould (Pythium aphanidermatum), abnormal mould (Pythium of female corruption Irregulare), pythium debaryanum (Pythium debaryanum), P. myriotylum (Pythium myriotylum), ultimate Rotten mould), rhizoctonia root rot, stem rot and damping-off (Rhizoctonia solani Kuhn), sclerotinite stem rot (Sclerotinia stem Decay) (sclerotinite), sclerotinite southern blight (neat bulbil bacterium (Sclerotinia rolfsii)), thielaviopsis sp root rot (thielaviopsis sp).
Active agent combinations/the compositions of the present invention can be additionally used in preparation and is applicable to therapeutic ground or prophylactically controls Treat the compositions that human body or animal fungal are sick, described mycosis such as mycosis, dermatosis, tineatonsurans and candidiasis or by song The disease that mould genus, such as Aspergillus fumigatus (Aspergillus fumigatus) cause.
Active agent combinations/compositions of the present invention has good plant tolerance and the poison favourable to homoiothermic animal concurrently Property and good environmental resistance, it is adaptable to protection plant and plant organ, raising are gathered productivity, the quality of improving harvested material And preventing and treating animal pests, particularly agricultural, gardening, herding, forest, park and leisure facilities, storage product and material guarantor Insecticide, arachnid, anthelmintic, nematicide and the Mollusca protected and run in health field.It is preferably used as plant and protects Protect agent.They are to generally sensitive and resistant species and all or some stage of development is active.Above-mentioned insect includes:
Anoplura (Anoplura, Phthiraptera), such as Damalinia (Damalinia spp.), Haematopinus (Haematopinus spp.), Linognathus (Linognathus spp.), louse belong to (Pediculus spp.), Trichodectes (Trichodectes spp.).
Arachnoidea (Arachnida), such as, Acarus siro (Acarus siro), Citrus aceria (Aceria Sheldoni), peronium Eriophyes (Aculops spp.), acupuncture Eriophyes (Aculus spp.), Amblyomma (Amblyomma Spp.), Argas (Argas spp.), Boophilus (Boophilus spp.), short whisker Acarapis (Brevipalpus spp.), Bryobia praetiosa (Bryobia praetiosa), Chorioptes (Chorioptes spp.), Dermanyssus gallinae (Dermanyssus Gallinae), wart demodicid mite (Epitrimerus pyri), true Tetranychus on Eotetranychus (Eotetranychus spp.), pears (Eutetranychus spp.), Eriophyes (Eriophyes spp.), half Tarsonemus (Hemitarsonemus spp.), Hyalomma (Hyalomma spp.), hard Ticks belong to (Ixodes spp.), latrodectus mactans (Latrodectus mactans), Metatetranychus spp., Oligonychus (Oligonychus spp.), Ornithodoros (Ornithodoros spp.), Panonychus citri belongs to (Panonychus spp.), Fructus Citri tangerinae rue rust mite (Phyllocoptruta oleivora), Polyphagotarsonemus latus Banks (Polyphagotarsonemus latus), Psoroptes (Psoroptes spp.), Rh (Rhipicephalus Spp.), root demodicid mite belongs to (Rhizoglyphus spp.), acaricide belongs to (Sarcoptes spp.), Middle East gold scorpion (Scorpio Maurus), Stenotarsonemus spp., Tarsonemus (Tarsonemus spp.), Tetranychus (Tetranychus Spp.), Vasates lycopersici.
Bivalve mollusks (Bivalva) guiding principle, such as, decorations shellfish belongs to (Dreissena spp.).
Lip foot mesh (Chilopoda), such as, DIWUGONG belongs to (Geophilus spp.), Scutigera spp..
Coleoptera (Coleoptera), such as, acanthoscelides obtectus (Acanthoscelides obtectus), beak rutelian belong to (Adoretus spp.), willow firefly chrysomelid (Agelastica alni), click beetle belong to (Agriotes spp.), Rhizoma Solani tuber osi gill angle Gold Testudinis (Amphimallon solstitialis), furniture death watch beetle (Anobium punctatum), Genus Anoplophora Hope (Anoplophora spp.), flower are as belonging to (Anthonomus spp.), Anthrenus (Anthrenus spp.), Ah gill Gold Testudinis Belong to (Apogonia spp.), Atomaria spp., fur moth belongs to (Attagenus spp.), dislikes bar bean weevil (Bruchidius Obtectus), bean weevil belong to (Bruchus spp.), ceutorhynchus (Ceuthorhynchus spp.), Cleonus mendicus, The chest stuffiness relieving Agriotes spp (Conoderus spp.), collar are as belonging to (Cosmopolites spp.), the brown New Zealand rib wing melolonthid (Costelytra zealandica), Curculio (Curculio spp.), the hidden beak of Yang Gan are as (Cryptorhynchus Lapathi), khapra beetle belongs to (Dermestes spp.), chrysomelid genus (Diabrotica spp.), epilachna genus (Epilachna Spp.), Nicotiana tabacum L. boring worm (Faustinus cubae), globose spider beetle (Gibbium psylloides), black different pawl sugarcane Gold Testudinis (Heteronychus arator), Hylamorpha elegans, North America house longhorn beetle (Hylotrupes bajulus), purple lucerne Mu leaf is as (Hypera postica), Hypothenemus spp., the big brown hock gill Gold Testudinis (Lachnosterna of Caulis Sacchari sinensis Consanguinea), colorado potato bug (Leptinotarsa decemlineata), rice root weevil (Lissorhoptrus Oryzophilus), cylinder beak is as belonging to (Lixus spp.), powder moth genus (Lyctus spp.), pollen beetle (Meligethes Aeneus), the west melolonthid in May (Melolontha melolontha), Migdolus spp., ink sky Bos (Monochamus spp.), Naupactus xanthographus, golden spider beetle (Niptus hololeucus), coconut palm moth rhinoceros gold Testudinis (Oryctes rhinoceros), saw-toothed grain beetle (Oryzaephilus surinamensis), black grape ear image (Otiorrhynchus sulcatus), little blue and white Gold Testudinis (Oxycetonia jucunda), Radix Cochleariae officinalis daikon leaf beetle (Phaedon Cochleariae), food phyllobranchia Gold Testudinis belong to (Phyllophaga spp.), Japan popillia flavosellata fairmaire (Popillia japonica), Weevil belongs to (Premnotrypes spp.), Brassica campestris L golden head flea beetle (Psylliodes chrysocephala), Ptinus (Ptinus spp.), dark-coloured ladybug (Rhizobius ventralis), lesser grain borer (Rhizopertha dominica), grain weevil belong to (Sitophilus spp.), point Rhynchophorus (Sphenophorus spp.), stem as belong to (Sternechus spp.), Symphyletes spp., tenebrio molitor (Tenebrio molitor), Tribolium (Tribolium spp.), speckle khapra beetle belong to (Trogoderma spp.), seed are as belonging to (Tychius spp.), Xylotrechus Chevrolat (Xylotrechus spp.), belonging to away from ground beetle (Zabrus spp.).
Collembola (Collembola), such as, arms Onychiurus arcticus (Onychiurus armatus).
Dermaptera (Dermaptera), such as, European earwig (Forficula auricularia).
Foot mesh (Diplopoda) again, such as, Blaniulus guttulatus.
Diptera (Diptera), such as, Aedes (Aedes spp.), Anopheles (Anopheles spp.), garden hair Mosquito (Bibio hortulanus), calliphora erythrocephala (Calliphora erythrocephala), Mediterranean Ceratitis spp (Ceratitis capitata), Carysomyia (Chrysomyia spp.), Callitroga (Cochliomyia spp.), people torsalo (Cordylobia anthropophaga), Culex (Culex spp.), Cuterebra (Cuterebra spp.), Fructus Canarii albi severe excess syndrome Fly (Dacus oleae), human botfly (Dermatobia hominis), Drosophila (Drosophila spp.), Fannia (Fannia spp.), Gasterophilus (Gastrophilus spp.), Hylemyia (Hylemyia spp.), Hyppobosca Spp., Hypoderma (Hypoderma spp.), Liriomyza (Liriomyza spp.), Lucilia (Lucilia spp.), family Fly belongs to (Musca spp.), Bemisia spp (Nezara spp.), Oestrus (Oestrus spp.), Oscinella frit (Oscinella frit), Herba chenopodii spring fly (Pegomyia hyoscyami), Phorbia (Phorbia spp.), Genus Stomoxys (Stomoxys spp.), Gadfly (Tabanus spp.), Tannia spp., Europe daddy-longlegs (Tipula paludosa), dirty fly Belong to (Wohlfahrtia app.).
Gastropoda (Gastropoda), such as, Arion spp., Biomphalaria (Biomphalaria spp.), vesicle spiral shell Belong to (Bulinus spp.), Agriolimax (Deroceras spp.), soil snail belongs to (Galba spp.), Lymnaea (Lymnaea Spp.), Katayama (Oncomelania spp.), amber spiro spp (Succinea spp.).
Anthelmintic guiding principle (Helminths), such as, Ancylostoma duodenale (Ancylostoma duodenale), Si Lilan Card hook worm (Ancylostoma ceylanicum), ancylostoma braziliense (Acylostoma braziliensis), the mouth of hook Turbatrix (Ancylostoma spp.), seemingly draw ascarid nematicide (Ascaris lubricoides), Ascaris (Ascaris Spp.), Malaysia cloth Shandong nematicide (Brugia malayi), cloth Shandong, Timor nematicide (Brugia timori), Bunostomum (Bunostomum spp.), Chabertia belong to (Chabertia spp.), branch testis trematodiasis belongs to (Clonorchis spp.), Gu Cypress Turbatrix (Cooperia spp.), Dicrocoelium (Dicrocoelium spp.), dictyocaulus filaria (Dictyocaulus filaria), fish tapeworm (Diphyllobothrium latum), guinea worm (Dracunculus medinensis), Echinococcus granulosus (Echinococcus granulosus), Echinococcus multilocularis (Echinococcus multilocularis), pinworm (Enterobius vermicularis), Faciola Spp., blood Trichinella (Haemonchus spp.), Heterakis (Heterakis spp.), short and small nibble shell cestode (Hymenolepis nana), Metastrongylus apri belong to (Hyostrongulus spp.), loa loa (Loa Loa), thin neck Turbatrix (Nematodirus spp.), oesophagostomum (Oesophagostomum spp.), Opisthorchis (Opisthorchis spp.), Onchocerca caecutiens (Onchocerca volvulus), this off-line Eimeria (Ostertagia difficult to understand Spp.), Paragonimus (Paragonimus spp.), Schistosomen spp., Fu Shi quasi-colubriformis (Strongyloides fuelleborni), strongyloides intestinalis (Strongyloides stercoralis), excrement Strongylus (Stronyloides spp.), taeniasis bovis (Taenia saginata), taeniasis suis (Taenia solium), rotation hair shape Nematicide (Trichinella spiralis), Trichinella nativa (Trichinella nativa), strain Trichinella britovi (Trichinella britovi), south trichinella (Trichinella nelsoni), Trichinella Pseudopsiralis, trichostrongylus (Trichostrongulus spp.), whipworm (Trichuris Trichuria), Wuchereria bancrofti (Wuchereria bancrofti).
In addition, it is possible to prevent and treat protozoacide, such as eimeria (Eimeria).
Heteroptera (Heteroptera), such as, squash bug (Anasa tristis), intend beautiful stinkbug belong to (Antestiopsis spp.), soil chinch bug belong to (Blissus spp.), pretty fleahopper belong to (Calocoris spp.), Campylomma livida, different back of the body chinch bug belong to (Cavelerius spp.), Cimex (Cimex spp.), Creontiades Dilutus, Fructus Piperis coried (Dasynus piperis), Dichelops furcatus, Hou Shi long rod lace bug (Diconocoris Hewetti), red cotton bug belongs to (Dysdercus spp.), America stinkbug belongs to (Euschistus spp.), Eurygasterspp belongs to (Eurygaster spp.), Heliopeltis spp., Horcias nobilellus, Leptocorisa spp belong to (Leptocorisa Spp.), leaf beak coried (Leptoglossus phyllopus), Lygus Hahn (Lygus spp.), sugarcane black chinch bug (Macropes Excavatus), Miridae (Miridae), Bemisia spp, Oebalus spp., Pentomidae, side butt stinkbug (Piesma Quadrata), wall stinkbug belongs to (Piezodorus spp.), cotton pseudo-speckle lower limb fleahopper (Psallus seriatus), Pseudacysta Persea, Rhodnius (Rhodnius spp.), Sahlbergella singularis (Sahlbergella singularis), black stinkbug belong to (Scotinophora spp.), pear crown network pentatomidae (Stephanitis nashi), Tibraca spp., Triatoma (Triatoma spp.).
Homoptera (Homoptera), such as, without net long tube Aphis (Acyrthosipon spp.), Aeneolamia Spp., Aphalaridae (Agonoscena spp.), Aleurodes spp., sugarcane Aleyrodes (Aleurolobus Barodensis), Aleurothrixus spp., really leafhopper belong to (Amrasca spp.), Anuraphis cardui, kidney circle Armored scale belongs to (Aonidiella spp.), Soviet Union bloom aphid (Aphanostigma piri), Aphis (Aphis spp), grape leaf Cicadae (Arboridia apicalis), roundlet armored scale belong to (Aspidiella spp.), Aspidiotus belong to (Aspidiotus spp.), Atanus spp., eggplant ditch are without net aphid (Aulacorthum solani), Aleyrodes (Bemisia spp.), Lee short-tail aphid (Brachycaudus helichrysii), Brachycolus spp., brevicoryne brassicae (Brevicoryne brassicae), little Brown back rice plant hopper (Calligypona marginata), beautiful yellow head cicadellid (Carneocephala fulgida), cane powder angle aphid (Ceratovacuna lanigera), Cercopidae (Cercopidae), lecanium belong to (Ceroplastes spp.), Fructus Fragariae Ananssae nail aphid (Chaetosiphon fragaefolii), sugarcane Huang Xue's armored scale (Chionaspis tegalensis), tea green leafhopper (Chlorita onukii), Semen Juglandis black speck aphid (Chromaphis juglandicola), dark brown Aspidiotus (Chrysomphalus ficus), Semen Maydis leafhopper (Cicadulina mbila), Coccomytilus halli, soft a red-spotted lizard belong to (Coccus spp.), tea hidden tumor aphid (Cryptomyzus ribis), Dalbulus spp., Dialeurodes spp., Diaphorina spp., white back of the body armored scale belong to (Diaspis spp.), Doralis spp., carry out giant coccid genus (Drosicha Spp.), western rounded tail Aphis (Dysaphis spp.), ash mealybug belong to (Dysmicoccus spp.), Empoasca flavescens (Empoasca spp.), woolly aphid belong to (Eriosoma spp.), Erythroneura spp., Euscelis bilobatus, coffee Coffee ground mealybug (Geococcus coffeae), phony disease of peach poison leafhopper (Homalodisca coagulata), mealy plum aphid (Hyalopterus arundinis), icerya purchasi belong to (Icerya spp.), sheet angle leafhopper belongs to (Idiocerus spp.), flat beak Leafhopper belongs to (Idioscopus spp.), small brown rice planthopper (Laodelphax striatellus), Lecanium spp., lepidosaphes shimer (Lepidosaphes spp.), radish aphid (Lipaphis erysimi), long tube Aphis (Macrosiphum spp.), Mahanarva fimbriolata, kaoliang aphid (Melanaphis sacchari), Metcalfiella spp., wheat are without net aphid (Metopolophium dirhodum), black edge flat wing speckle aphid (Monellia costalis), Monelliopsis Pecanis, tumor aphid genus (Myzus spp.), Caulis et Folium Lactucae sativae patch up Macrosiphus spp (Nasonovia ribisnigri), rice green leafhopper genus (Nephotettix spp.), brown paddy plant hopper (Nilaparvata lugens), Oncometopia spp., Orthezia Praelonga, Fructus Myricae rubrae edge aleyrodid (Parabemisia myricae), Paratrioza spp., Parlatoria (Parlatoria Spp.), Pemphigus (Pemphigus spp.), com planthopper (Peregrinus maidis), Phenacoccus (Phenacoccus spp.), Yang Ping wing woolly aphid (Phloeomyzus passerinii), phorodon aphid (Phorodon Humuli), grape phylloxera belong to (Phylloxera spp.), the brown point of sago cycas armored scale (Pinnaspis aspidistrae), Buttocks stricture of vagina mealybug belongs to (Planococcus spp.), the former giant coccid of pyriform (Protopulvinaria pyriformis), white mulberry scale (Pseudaulacaspis pentagona), mealybug belong to (Pseudococcus spp.), Psylla spp (Psylla spp.), gold Nikol (Pteromalus spp.), Pyrilla spp., large bamboo hat with a conical crown and broad brim Aspidiotus belong to (Quadraspidiotus spp.), Quesada Gigas, flat thorn mealybug belong to (Rastrococcus spp.), Rhopalosiphum (Rhopalosiphum spp.), black bourch genus (Saissetia spp.), Scaphoides titanus, green bugs (Schizaphis graminum), sago cycas thorn targe A red-spotted lizard (Selenaspidus articulatus), long clypeus plant hopper belong to (Sogata spp.), white backed planthopper (Sogatella Furcifera), Sogatodes spp., Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, wide breast froghopper belong to (Tomaspis spp.), sound Aphis (Toxoptera spp.), greenhouse Aleyrodid (Trialeurodes vaporariorum), individual Psylla spp (Trioza spp.), jassids belong to (Typhlocyba Spp.), point armored scale belongs to (Unaspis spp.), Fructus Vitis viniferae root nodule louse (Viteus vitifolii).
Hymenoptera (Hymenoptera), such as, Diprion (Diprion spp.), real tenthredinidae (Hoplocampa Spp.), hair ant belongs to (Lasius spp.), MonomoriumMayr (Monomorium pharaonis), Vespa (Vespa spp.).
Isopoda (Isopoda), such as, Armadillidium (Armadillidium vulgare), comb beach louse (Oniscus Asellus), ball Armadillidium (Porcellio scaber).
Isoptera (Isoptera), such as, Reticulitermes (Reticulitermes spp.), odontotermes (Odontotermes spp.).
Lepidoptera (Lepidoptera), such as, Sang Jian Autographa spp (Acronicta major), white macula are tired of noctuid (Aedia Leucomelas), Agrotis (Agrotis spp.), cotton leaf ripple noctuid (Alabama argillacea), dry very noctuid Belong to (Anticarsia spp.), Barathra brassicae, cotton lyonetid (Bucculatrix thurberiella), pine chi Earwig (Bupalus piniarius), Caulis et Folium Lini Huang volume moth (Cacoecia podana), Capua reticulana, codling moth (Carpocapsa pomonella), winter geometrid moth (Cheimatobia brumata), straw borer spp (Chilo spp.), fir color Volume moth (Choristoneura fumiferana), grape codling moth (Clysia ambiguella) (Clysia ambiguella), Cnaphalocerus Spp., earias insulana (Earias insulana), Anagasta kuehniella (Ephestia kuehniella), pornography and drug moth (Euproctis chrysorrhoea), cutworm belong to (Euxoa spp.), dirty cut Noctua (Feltia spp.), greater wax moth (Galleria mellonella), genus heliothis (Helicoverpa spp.), Heliothis (Heliothis spp.), brown Knit moth (Hofmannophila pseudospretella), tea long paper moth (Homona magnanima), apple ermine moth (Hyponomeuta padella), greedy Noctua (Laphygma spp.), Herba Marsileae Quadrifoliae thin moth (Lithocolletis Blancardella), green fruit winter noctuid (Lithophane antennata), the white grand cutworm (Loxagrotis of bean Albicosta), Euproctis (Lymantria spp.), malacosoma neustria (Malacosoma neustria), lopper worm (Mamestra brassicae), rice hair shin noctuid (Mocis repanda), mythimna separata (Mythimna separata), Oria Spp., Oulema oryzae (Oulema oryzae), small noctuid (Panolis flammea), Pectinophora gossypiella (Pectinophora gossypiella), Fructus Citri tangerinae lyonetid (Phyllocnistis citrella), Pieris spp (Pieris Spp.), diamond-back moth (Plutella xylostella), spodoptera (Prodenia spp.), Pseudaletia spp., big Bean noctuid (Pseudoplusia includens), Pyrausta nubilalis (Hubern). (Pyrausta nubilalis), Spodoptera (Spodoptera spp.), Thermesia gemmatalis, bag rain moth (Tinea pellionella), curtain rain moth (Tineola bisselliella), oak green volume moth (Tortrix viridana), powder Noctua (Trichoplusia Spp.).
Orthoptera (Orthoptera), such as, family Xi (Acheta domesticus), oriental cockroach (Blatta Orientalis), blatta germanica (Blattella germanica), Gryllotalpa spp (Gryllotalpa spp.), leucophaea maderae (Leucophaea maderae), Locustamigratoria (Linnaeus) belong to (Locusta spp.), black locust belongs to (Melanoplus spp.), periplaneta americana (Periplaneta americana), desert locust (Schistocerca gregaria).
Siphonaptera (Siphonaptera), such as, Ceratophyllus (Ceratophyllus spp.), Xanthopsyllacheopis (Xenopsylla cheopis).
Comprehensive mesh (Symphyla), such as, kahikatea worm (Scutigerella immaculata).
Thysanoptera (Thysanoptera), such as, rice thrips (Baliothrips biformis), Enneothrips Flavens, flower thrips belong to (Frankliniella spp.), net Thrips (Heliothrips spp.), greenhouse bar hedge thrips (Hercinothrips femoralis), card Thrips (Kakothrips spp.), Fructus Vitis viniferae thrips (Rhipiphorothrips Cruentatus), hard Thrips (Scirtothrips spp.), Taeniothrips cardamoni, Thrips (Thrips Spp.).
Thysanoptera (Thysanura), such as, lepismae saccharinae (Lepisma saccharina).
Plant nematode includes, such as, and eel Turbatrix (Anguina spp.), Aphelenchoides (Aphelenchoides spp.), thorn Turbatrix (Belonoaimus spp.), Bursaphelenchus (Bursaphelenchus Spp.), fuller's teasel Ditylenchus dipsaci (Ditylenchus dipsaci), ball Heterodera (Globodera spp.), helicotylenchus Belong to (Heliocotylenchus spp.), Heterodera (Heterodera spp.), minute hand Turbatrix (Longidorus Spp.), Meloidogyne (Meloidogyne spp.), Pratylenchidae belong to (Pratylenchus spp.), Radopholus similis Throne (Radopholus similis), shallow bid spin line Eimeria (Rotylenchus spp.), burr Turbatrix (Trichodorus Spp.), Tylenchorhynchus (Tylenchorhynchus spp.), pulvinulus sword Turbatrix (Tylenchulus spp.), half puncture Nematicide (Tylenchulus semipenetrans), Xiphinema (Xiphinema spp.).
The active agent combinations of the present invention is not only to plant pests, health nuisance and storage product nuisance tool Active, and Ticks, soft ticks, scabies such as hard to parazoon (vermin and endoparasite) in field of veterinary Demodicid mite, trombiculid, fly (bite and suck), tachinid larva, louse, hair louse, poultry louse and flea are the most active.Described parasite includes:
Anoplura (Anoplurida), such as Haematopinus, Linognathus, louse genus, Phtirus spp., pipe louse belong to (Solenopotes spp.)
Mallophaga (Mallophagida) and Amblycera (Amblycerina) and thin angle suborder (Ischnocerina), Such as hair Trichodectes (Trimenopon spp.), Menopon (Menopon spp.), huge Trichodectes (Trinoton spp.), cattle Trichodectes (Bovicola spp.), Werneckiella spp., Lepikentron spp., Damalinia, Trichodectes, cat poultry louse Belong to (Felicola spp.)
Diptera and Nematocera (Nematocerina) and Brachycera (Brachycerina), such as Aedes, press Uranotaenia, Culex, Simulium (Simulium spp.), Eusimulium (Eusimulium spp.), owl midge (Phlebotomus Spp.), Lutzomyia (Lutzomyia spp.), Bitting midge (Culicoides spp.), Chrysops (Chrysops spp.), tumor Gadfly (Hybomitra spp.), Atylotus (Atylotus spp.), Gadfly, Chrysozona (Haematopota spp.), Philipomyia spp., honeybee Hippobosca (Braula spp.), Musca, Hydrotaea (Hydrotaea spp.), sting fly Belong to, Haematobia (Haematobia spp.), not fly belong to (Morellia spp.), Fannia, Glossina (Glossina Spp.), Calliphora (Calliphora spp.), Lucilia, Carysomyia, Wohlfahrtia, Sarcophaga (Sarcophaga spp.), mad Fly genus, Hypoderma, Gasterophilus (Gasterophilus spp.), Hippobosca (Hippobosca spp.), Lipoptena (Lipoptena spp.) and Melophagus (Melophagus spp.)
Siphonaptera (Siphonapterida), such as flea belong to (Pulex spp.), Ctenocephalus (Ctenocephalides Spp.), visitor flea belongs to (Xenopsylla spp.) and Ceratophyllus
Heteroptera (Heteropterida), such as Cimex, Triatoma, Rhodnius and Triatoma (Panstrongylus spp.)
Blattaria (Blattarida), such as oriental cockroach, periplaneta americana, blatta germanica and Supella (Supella Spp.)
Acari (Acar, Acarina) and rear valve mesh (Metastigmate) and Mesostigmata (Mesostigmata), such as Argas, Ornithodoros (Ornithodorus spp.), residual beak Ticks belong to (Otobius Spp.), hard Ticks genus, Amblyomma, Boophilus, Dermacentor (Dermacentor spp.), Haemophysalis spp., glass eye Ticks Genus, Rh, Dermanyssus (Dermanyssus spp.), thorn profit demodicid mite belong to (Raillietia spp.), Pneumonyssus (Pneumonyssus spp.), breast thorn demodicid mite belongs to (Sternostoma spp.) and Vespacarus (Varroa spp.)
Axle Acarina (Actinedida) (front valve suborder (Prostigmata)) and flour mite mesh (Acaridida) are (without valve Suborder (Astigmata)), such as honeybee shield demodicid mite belongs to (Acarapis spp.), Cheyletiella (Cheyletiella spp.), fowl chela Demodicid mite belongs to (Ornithocheyletia spp.), Myobia (Myobia spp.), Psorergates (Psorergates spp.), compacted shape Demodicid mite belongs to (Demodex spp.), Trombidium (Trombicula spp.), Listrophorus spp., Tyroglyphus (Acarus Spp.), under Tyrophagus (Tyrophagus spp.), Caloglyphus (Caloglyphus spp.), neck, demodicid mite belongs to (Hypodectes spp.), wing demodicid mite belong to (Pterolichus spp.), Psoroptes, Chorioptes, ear acaricide genus (Otodectes Spp.), acaricide genus, Notoedres (Notoedres spp.), lump demodicid mite belong to (Knemidocoptes spp.), Cytodites (Cytodites spp.) and Laminosioptes (Laminosioptes spp.).
Active agent combinations/the compositions of the present invention be also applied for preventing and treating attack following animal arthropod: agriculture Industry output domestic animal, such as cattle, sheep, goat, horse, pig, donkey, camel, Babalus bubalis L., rabbit, family chicken, turkey, duck, goose and Apis； Other pet animal, such as Canis familiaris L., cat, cage bird and pet fish；And so-called experimental animal, such as hamster, Cavia porcellus, rat and little Mus.By preventing and treating described arthropod, the situation that dead and volume of production (meat, milk, hair, skin, egg, honey etc.) reduces is deserved to subtract Few, thus the active agent combinations of the application of the invention animal feeding can be made more economical, easier.
Active agent combinations/the compositions of the present invention is used for veterinary applications in a known way and moves by following form During thing is raised: by such as tablet, capsule, potus, gavage medicine, granule, unguentum, pill, feed (feed-through) The mode of method and suppository carries out enteral administration；Intestinal is carried out by such as injection (intramuscular, subcutaneous, intravenous, intraperitoneal etc.), implantation Stomach external administration；Pass through nasal administration；By such as soaking or taking a shower, spray, sprinkle and water and drop, cleaning, the form skin of dusting It is administered, and by means of including the moldings such as necklace, ear tag of reactive compound, tail tag, limbs ligature (limb Band), halter, marker etc..
When domestic animal, poultry, pet animal etc., active agent combinations of the present invention can be as including 1 to 80 weight % The preparation (such as powder, Emulsion, free flowing composition) of the reactive compound of amount directly uses or dilutes 100 to 10000 times Rear use, or they can chemistry Medicatedbath lotion (chemical bath) form use.
Make moreover, it has been discovered that the active agent combinations of the present invention has strong parasite killing to the insecticide damaging industrial materials With.
It is proposed that following insecticide in the way of example and preferred and without any restrictions property:
Beetle, such as North America house longhorn beetle, Chlorophorus pilosis, furniture death watch beetle, reports dead death watch beetle (Xestobium Rufovillosum), Ptilinus pectinicornis (Ptilinus pecticornis), Dendrobium pertinex, pine death watch beetle (Ernobius mollis), Priobium carpini, Lyctus brunneus Stephens (Lyctus brunneus), the moth-eaten (Lyctus of Africa powder Africanus), south powder moth-eaten (Lyctus planicollis), quercitron moth-eaten (Lyctus linearis), pubescence powder moth (Lyctus pubescens), Trogoxylon aequale, minthea rugicollis (Minthes rugicollis), material bark beetle kind (Xyleborus spec.), Tryptodendron spec., coffee black long moth-eaten (Apate monachus), Mongolian oak length moth (Bostrychus capucins), brown different wing length moth-eaten (Heterobostrychus brunneus), spine length moth kind (Sinoxylon spec.), dinoderus minutus (Dinoderus minutus)；
Hymenopteran (Hymenopterons), the biggest wood wasp (Sirex juvencus), the big wood wasp of fir (Urocerus gigas), Urocerus gigas toiganus (Urocerus gigas taignus), Urocerus augur；
Coptotermes formosanus Shtrari., such as Europe kalotermitid (Kalotermes flavicollis), fiber crops head heap sand Coptotermes formosanus Shtrari. (Cryptotermes Brevis), ash puts different Coptotermes formosanus Shtrari. (Heterotermes indicola), American-European reticulitermes flavipe (Reticulitermes Flavipes), Sang Te reticulitermes flavipe (Reticulitermes santonensis), southern Europe reticulate pattern Coptotermes formosanus Shtrari. (Reticulitermes Lucifugus), Mastotermes darwiniensis (Mastotermes darwiniensis), Nevada Gu Coptotermes formosanus Shtrari. (Zootermopsis Nevadensis), Coptotermes formosanus Shtrari． (Coptotermes formosanus)；
Moth (Bristletail), such as lepismae saccharinae.
In the present invention, the implication of industrial materials is interpreted as non-living body (non-living) material, for example, it is preferable to be plastics, Binding agent, sizing material, paper and sheet material, leather, timber and woodworking article, and coating composition.
If appropriate, described i.e. use compositions can contain other insecticide, and the most also can be containing a kind of or many Plant antibacterial.
About the additive that other is possible, refer to above-mentioned insecticide and antibacterial.
Active agent combinations/the compositions of the present invention is equally applicable to the thing that protection contacts with saline or brackish water Body, particularly hull, sieve, net, building, harbour and signaling system, in case producing dirt.
Additionally, the active agent combinations/compositions of the present invention can individually or with other reactive compound in combination As anti-fouling agent.
In domestic, health and storage product protection, the active agent combinations/compositions of the present invention is further adapted for preventing and treating The animal pest existed in confined space, particularly insecticide, arachnid and acarid, described confined space such as residence, work Factory workshop, office, compartment etc..They can individually or be conveniently used in combination with other reactive compound and auxiliary agent Domestic insecticide products is prevented and treated these insects.They are to sensitive and species of resistance the most active to whole stages of development.This A little insects include:
Scorpionida (Scorpionidea), such as Mediterranean Huang scorpion (Buthus occitanus).
Acarina, such as adobe tick (Argas persicus), argas reflexus (Argas reflexus), tongue demodicid mite Asia Plant (Bryobia ssp.), Dermanyssus gallinae, family addicted to sweet demodicid mite (Glyciphagus domesticus), tampan tick (Ornithodorus moubat), brown dog tick (Rhipicephalus sanguineus), eutrombicula alfreddugesi (Trombicula alfreddugesi), Neutrombicula autumnalis, spy are addicted to skin demodicid mite (Dermatophagoides Pteronissimus), method is addicted to skin demodicid mite (Dermatophagoides forinae).
Araneida (Araneae), such as catching bird spider (Aviculariidae), circle spider (Araneidae).
Opiliones (Opiliones), such as chelifer (Pseudoscorpiones chelifer), Pseudoscorpiones cheiridium, long blind spider (Opiliones phalangium).
Isopoda, such as comb beach louse, ball Armadillidium.
Foot mesh, such as Blaniulus guttulatus, mountain cricket Eimeria (Polydesmus spp.) again.
Lip foot mesh, such as DIWUGONG belong to.
Lepismae saccharinae mesh (Zygentoma), such as comb lepismae saccharinae belong to (Ctenolepisma spp.), lepismae saccharinae, robber fireworm (Lepismodes inquilinus).
Blattaria, such as oriental cockroach, blatta germanica, Asia Lian (Blattella asahinai), leucophaea maderae, angle abdomen Lian belongs to (Panchlora spp.), wood Lian belongs to (Parcoblatta spp.), Australian cockroach (Periplaneta Australasiae), periplaneta americana, big brown big Lian (Periplaneta brunnea), smoke Perilpaneta americana (Periplaneta Fuliginosa), brown belt cockroach (Supella longipalpa).
Jump mesh (Saltatoria), such as family Xi.
Dermaptera, such as European earwig.
Isoptera, such as kalotermitid belong to (Kalotermes spp.), Reticulitermes.
Corrodentia (Psocoptera), such as Lepinatus spp., powder corrodent belong to (Liposcelis spp.).
Coleoptera (Coleoptera), such as Anthrenus, fur moth belong to, khapra beetle belongs to, long head ostomatid (Latheticus Oryzae), hidden instep cuckoo Eimeria (Necrobia spp.), Ptinus, lesser grain borer, grain weevil (Sitophilus granarius), rice As (Sitophilus oryzae), sitophilus zea-mais (Sitophilus zeamais), Stegobium paniceum (Stegobium paniceum).
Diptera, such as Aedes aegypti (Aedes aegypti), Aedes albopictus (Aedes albopictus), band beak she Mosquito (Aedes taeniorhynchus), Anopheles, calliphora erythrocephala, great number fiber crops horsefly (Chrysozona pluvialis), multicolored vaginal discharge Culex pipiens pallens (Culex quinquefasciatus), northern house (Culex pipiens), ring beak culex (Culex Tarsalis), Drosophila (Drosophila spp.), Fannia canicularis (Fannia canicularis), housefly (Musca Domestica), owl midge, flesh fly (Sarcophaga carnaria), Simulium, tatukira (Stomoxys calcitrans), Europe daddy-longlegs.
Lepidoptera, such as lesser wax-moth (Achroia grisella), greater wax moth, Indian meal moth (Plodia Interpunctella), stopper rain moth (Tinea cloacella), bag rain moth, curtain rain moth.
Siphonaptera, such as ctenocephalides canis (Ctenocephalides canis), ctenocephalides felis (Ctenocephalides Felis), Pulex irritans (Pulex irritans), chigo (Tunga penetrans), Xanthopsyllacheopis.
Hymenoptera, such as, blazon back of a bow ant (Camponotus herculeanus), black smelly ant (Lasius Fuliginosus), black ant (Lasius niger), Lasius umbratus, MonomoriumMayr, Paravespula spp., causeway Ant (Tetramorium caespitum).
Anoplura (Anoplura), such as head louse (Pediculus humanus capitis), body louse (Pediculus Humanus corporis), Pemphigus spp., Phylloera vastatrix, pubic louse (Phthirus pubis).
Heteroptera, such as cimex hemipterus (Cimex hemipterus), bed bug (Cimex lectularius), length Red hunt stinkbug (Rhodinus prolixus), invade and harass triatomid (Triatoma infestans).
In domestic field of pesticides, they can individually or be used in combination with other suitable reactive compound, institute State suitable reactive compound such as phosphoric acid ester, carbamates, pyrethroid, anabasine, growth regulator Or the reactive compound of other known insecticides kind.
They can use with following form: aerosol, nothing pressure spray product such as pump spraying and atomizer spray, automatic mist Change system, propellant, foam, gel, have by the evaporant product of cellulose or the evaporating plate of polymer, liquid Evaporant, gel and film evaporant, the evaporant of impeller driven, unpowered or passive vapo(u)rization system, catch moth paper, catch moth bag and Catch moth glue, as granule or powder agent, be used for shedding in bait or in Poison bait station (bait station).
Additionally, the conjugate of the present invention and compositions can be additionally used in reduces mycotoxin in plant and vegetable material of gathering Content, and thus reduce the content of mycotoxin in the food and animal feed being made from.
Following mycotoxin can particularly, but not exclusively, be proposed:
Deoxynivalenol (Deoxynivalenole, DON), nivalenol (Nivalenole), 15-Ac- DON, 3-Ac-DON, T2-and HT2-toxin, fumonisins (Fumonisines), 6-(10-hydroxy-6-oxo-trans-1-undecenyl)-.beta.-resorcylic acid lactone (Zearalenone), Moniliformin (Moniliformine), fusarine (Fusarine), Diacetoxysciroenol (Diaceotoxyscirpenole, DAS), muscardine toxin (Beauvericine), enniatine (Enniatine), Fusaroproliferine, Fusarenole, ochracin (Ochratoxines), patulin (Patuline), ergot alkaloid (Ergotalkaloides) and aflatoxin (Aflatoxines), they are caused by following fungal disease: fusarium Belong to, such as orange fusarium (Fusarium acuminatum), Herba bromi japonici fusarium (F.avenaceum), F.crookwellense, Huang Color fusarium (F.culmorum), F.graminearum schw (F.graminearum) (Gibberella zeae (Gibberella zeae)), Herba Equiseti Hiemalis Fusarium (F.equiseti), F.fujikoroi, Fructus Musae Fusarium spp. (F.musarum), point fusarium (F.oxysporum), proliferation sickle Cutter bacterium (F.proliferatum), annual bluegrass fusarium (F.poae), F.pseudograminearum, Ramulus Sambuci Williamsii fusarium (F.sambucinum), grass sickle spore (F.scirpi), F.semitectum (F.semitectum), eggplant fusarium (F.solani), plan Branch spore fusarium (F.sporotricholides), F.langsethiae, glue fusarium oxysporum (F.subglutinans), three line sickles Cutter bacterium (F.tricinctum), fusarium moniliforme (F.verticillioides) and other fungal disease；And aspergillus kind, Penicillium kind, purple Clavicipitaceae (Claviceps purpurea), Stachybotrys (Stachybotrys spec.) kind etc..
The extraordinary bactericidal effect of conjugate of the present invention or compositions is shown in following example.Although single activation Compound only shows weak sterilization drug effect, but the drug effect that conjugate of the present invention or compositions show is more than each compound drug effect Simply add and.
If the sterilization drug effect of conjugate of the present invention or compositions is more than two or three activation according to S.R.Colby , then there is the cooperative effect of antibacterial in the expection drug effect of the conjugate of compound, described S.R.Colby expects drug effect (" Calculation of the synergistic and antagonistic responses of herbicide Combinations ", Weeds1967,15,20-22) calculate as described below:
If
X is the actual measurement drug effect of the compound (A) of given dose (m ppm),
Y is the actual measurement drug effect of the compound (B) of given dose (n ppm),
Z is the actual measurement drug effect of the compound (C) of given dose (r ppm),
E1 is the compound (A) of m and n ppm given dose actual measurement drug effect together with compound (B),
E2 is the compound (A) of m, n and r ppm given dose, the compound (B) actual measurement medicine together with compound (C) Effect,
The Colby formula of binary mixture can as follows define:
The Colby formula of ternary compound can as follows define:
Drug effect is in terms of %.The drug effect of 0% means the drug effect corresponding to matched group, and the drug effect of 100% means not observe disease Evil.
In the case of the bactericidal effect actually observed is more than the expection drug effect calculated with Colby formula, the present invention ties Compound or compositions have superadditivity, and cooperative effect i.e. be can be observed.
The present invention is illustrated by following example.
Embodiment 1
Piricularia oryzae test (rice)/preventative
Solvent: 50 weight portion N,N-dimethylformamides
Emulsifying agent: 1 weight portion alkylaryl polyglycol ether
For preparing suitable active agent preparations, by solvent and the emulsifying of the reactive compound of 1 weight portion and described amount Agent mixes, and with water, dope is diluted to desired concn.
For carrying out prophylactic activity test, spray young plant with active agent preparations with described rate of application.Sprinkling layer becomes After Gan, spray plant with the conidial suspension of piricularia oryzae (Pyricularia oryzae).Subsequently plant is put into In 100% relative atmospheric humidity, the greenhouse of 25 DEG C.
After inoculating 10 days, this test is estimated.0% means to be equivalent to the drug effect of matched group, and the drug effect of 100% means Do not observe disease.
Table 1
Piricularia oryzae test (rice)/preventative
Embodiment 2
Dlumeria graminis test (Fructus Hordei Vulgaris)/5 day are preventative
Solvent: 50 weight portion DMAC N,N' dimethyl acetamides
Emulsifying agent: 1 weight portion alkylaryl polyglycol ether
For preparing suitable active agent preparations, by the reactive compound of 1 weight portion or active agent combinations with The solvent of described amount and emulsifying agent mixing, and with water, dope is diluted to desired concn.
For carrying out prophylactic activity test, spray with described rate of application with the preparation of reactive compound or active agent combinations Spill young plant.
It is spray applied latter 5 days, by the spore of grass family dlumeria graminis (Blumeria graminis f.sp.hordei) It is sprinkling upon on this plant.
Plant is put into that temperature is about 20 DEG C, relative atmospheric humidity is about in the greenhouse of 80%, to promote that mycotic spore is sent out Educate.
Inoculate latter 7 days and this test is estimated.0% means to be equivalent to the drug effect of matched group, and the drug effect of 100% means not Observe disease.
Table 2
Dlumeria graminis test (Fructus Hordei Vulgaris)/5 day are preventative
The drug effect formula of the conjugate of two kinds of compounds
The expection drug effect of the conjugate of two kinds of given compounds be calculated as follows (see Colby, S.R., “Calculating Synergistic and antagonistic Responses of Herbicide Combinations ", Weeds15, the 20-22 page, 1967):
If
X is to represent with the % mortality rate of untreated control groupmPpm ormThe drug effect of the test compound A of g/ha concentration,
Y is to represent with the % mortality rate of untreated control groupnPpm ornThe drug effect of the test compound B of g/ha concentration,
Z is to represent with the % mortality rate of untreated control groupoPpm oroThe drug effect of the test compound C of g/ha concentration,
E be with the % mortality rate of untreated control group represent withM, n and oPpm orM, n and oG/ha administered compound A, The drug effect of the mixture of B and C,
Then
If the actual measurement parasite killing drug effect of conjugate is higher than value of calculation " E ", then the conjugate of the two compound has super , i.e. there is cooperative effect in additivity.
Embodiment 3
Bollworm is tested
Solvent: the dimethylformamide of 7 weight portions
Emulsifying agent: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations, by solvent and the emulsifying of the reactive compound of 1 weight portion and described amount Agent mixes, and this dope water containing emulsifying agent is diluted to desired concn.
The active agent preparations sprinkling of Semen sojae atricolor (Glycine max) leaf desired concn processes, and the most damp at blade With bollworm (Heliothis armigera) larval infestation time wet.
After the designated time period, determine the mortality rate in terms of %.100% represents that all caterpillars are killed；0% indicates without hair Worm is killed.
In this experiment, such as, the application show cooperative effect compared with single compound below in conjunction with thing:
Table 3: bollworm is tested
The parasite killing drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with Colby formula
Embodiment 4
Brown paddy plant hopper-test
Solvent: the dimethylformamide of 7 weight portions
Emulsifying agent: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations, by solvent and the emulsifying of the reactive compound of 1 weight portion and described amount Agent mixes, and this dope water containing emulsifying agent is diluted to desired concn.
The active agent preparations sprinkling of rice (Oryza sativa) plant desired concn processes, and the most damp at blade With brown paddy plant hopper (Nilaparvata lugens) larval infestation time wet.
After the designated time period, determine the mortality rate in terms of %.100% represents that all brown paddy plant hopper larvas are killed；0% table Show and be killed without brown paddy plant hopper larva.
In this experiment, such as, the application show cooperative effect compared with single compound below in conjunction with thing:
Table 4: brown paddy plant hopper is tested
The parasite killing drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with Colby formula
Embodiment 5
Radix Cochleariae officinalis daikon leaf beetle-test
Solvent: the dimethylformamide of 7 weight portions
Emulsifying agent: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations, by solvent and the emulsifying of the reactive compound of 1 weight portion and described amount Agent mixes, and this dope water containing emulsifying agent is diluted to desired concn.
The active agent preparations sprinkling of Caulis et Folium Brassicae capitatae (Brassica oleracea) leaf desired concn processes, and at blade With the larval infestation of Radix Cochleariae officinalis daikon leaf beetle (Phaedon cochleariae) time moist not yet.
After the designated time period, determine the mortality rate in terms of %.100% represents that all Radix Cochleariae officinalis ape leaf larvas are killed；0% Indicate and be killed without Radix Cochleariae officinalis ape leaf larva.
In this experiment, such as, the application show cooperative effect compared with single compound below in conjunction with thing:
Table 5-1: Radix Cochleariae officinalis daikon leaf beetle-test
The parasite killing drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with Colby formula
Table 5-2: Radix Cochleariae officinalis daikon leaf beetle-test
The parasite killing drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with Colby formula
Embodiment 6
Noctuid test is coveted on meadow
Solvent: the dimethylformamide of 7 weight portions
Emulsifying agent: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations, by solvent and the emulsifying of the reactive compound of 1 weight portion and described amount Agent mixes, and this dope water containing emulsifying agent is diluted to desired concn.
Caulis et Folium Brassicae capitatae (Brassica oleracea) leaf is processed by immersing the active agent preparations of desired concn, And covet the larval infestation of noctuid (Spodoptera frugiperda) with meadow when blade is moist not yet.
After the designated time period, determine the mortality rate in terms of %.100% represents that all caterpillars are killed；0% indicates without hair Worm is killed.
In this experiment, such as, the application show cooperative effect compared with single compound below in conjunction with thing:
Noctuid test is coveted on table D: meadow
The parasite killing drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with Colby formula

Claims (17)

1. a conjugate, including:
(A) isotianil
With
(B) imidacloprid
With
(C) another is selected from the reactive compound of following insecticidal active compound: ethiprole and ethiprole,
Weight ratio between the most any two kinds of components (A), (B) or (C) is 1:50 to 50:1 independently of one another.
2. the conjugate of claim 1, including (A) 3,4-bis-chloro-N-(2-cyano-phenyl)-5-isothiazole formamide and (B) pyrrole Worm quinoline and (C) ethiprole.
3. the conjugate of claim 1 or 2, also includes auxiliary agent.
4. the conjugate of claim 1 or 2, also includes solvent, carrier or surfactant.
5. the conjugate of claim 1 or 2, also includes filler.
6. therapeutic or the microorganism of preventative preventing and treating plant and/or a method for insect, including using in the following manner Conjugate any one of claim 1 to 5: be applied to plant propagation material, plant, or described plant growing or treat The soil of growth.
7. the method for claim 6, the conjugate including using in the following manner any one of claim 1 to 5: executed For seed.
8. the method for claim 6, the conjugate including using in the following manner any one of claim 1 to 5: executed Fruit for described plant.
9. the method for claim 6 or 7, including simultaneously or sequentially administered compound (A), (B) and (C).
10. the method for claim 6 or 7, wherein the amount of the conjugate any one of claim 1 to 5 is for blade face and soil It is 0.1g/ha to 10kg/ha for process, is 2 to 200g/100kg seed for seed treatment.
The method of 11. claim 6, wherein said microorganism is phytopathogen.
The method of 12. claim 6, wherein said plant is crop.
Conjugate any one of 13. claim 1 to 5 is for processing the purposes of seed.
The purposes of 14. claim 13, is used for processing transgenic seed.
15. protection seeds and/or the bud of plant grown up to by seed and leaf protect it from insect or the method for bacterium infringement, the method Unseeded seed is processed including with the conjugate any one of a kind of claim 1 to 5.
The method of 16. claim 15, wherein said seed compound (A), (B) and (C) processes simultaneously.
The method of 17. claim 15, wherein said seed compound (A), (B) and (C) separately processes.
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