CN104886059B

CN104886059B - Active ingredient combination capable of killing insects and mites

Info

Publication number: CN104886059B
Application number: CN201510119362.7A
Authority: CN
Inventors: H·亨格伯格; P·耶施克; R·维尔坦; W·蒂勒特
Original assignee: Bayer CropScience AG
Current assignee: Bayer Intellectual Property GmbH; Bayer CropScience AG
Priority date: 2009-03-25
Filing date: 2009-03-25
Publication date: 2017-04-12
Anticipated expiration: 2029-03-25
Also published as: CN104886059A

Abstract

The invention relates to a novel active ingredient combination, which comprises: at least a compound of a known formula (I) (wherein R1 and A are as defined in the specification) and at least another known active ingredient such as a chitin synthesis inhibitor or a molting hormone agonist, and is well applicable to prevention and elimination of animal pests, such as insects and unwanted mites.

Description

With the active ingredient combination for killing insecticide and mite killing worm characteristic

The application be submit on March 25th, 2009 it is entitled " have kill the activity of insecticide and mite killing worm characteristic into The divisional application of No. 200980159532.7 application for a patent for invention of point conjugate ".

Technical field

The present invention relates to new active agent combinations, which includes at least one known formula (I) compound first, its It is secondary including at least one other known activity selected from chitin synthesis inhibitor class, ecdysone agonist class or other classifications Compound, the conjugate are extremely suitable to prevent and treat animal pests (animal pest), such as insecticide and undesired acarid.This The bright method further related to for preventing and treating animal pests on Plants and Seeds, is related to active agent combinations of the present invention for locating The purposes of reason seed, is related to protection of the method for seed, and finally but is not least importantly related to Jing reactive compounds of the present invention The seed of conjugate process.

Background technology

Known formula (I) compound has insecticidal action (referring to EP 0 539 588, WO 2007/115643 A1, WO 2007/115646 A1 of 2007/115644 A1 and WO)

Wherein

A represents pyridine -2- bases or pyridin-4-yl, or represents on 6- positions optionally by the pyridine -3- of following substituent group Base：Fluorine, chlorine, bromine, methyl, trifluoromethyl or trifluoromethoxy, or represent on 6- positions optionally by chlorine or methyl substituted rattle away Piperazine -3- bases, or pyrazine -3- bases are represented, or 2- chloropyrazine -5- bases are represented, or representative is optionally taken by chlorine or methyl on 2- positions 1,3-thiazoles -5- the bases in generation, or

A represent optionally by the pyrimidine radicals of following substituent group, pyrazolyl, thienyl, oxazolyl, isoxazolyls, 1,2, 4- oxadiazolyls, isothiazolyl, 1,2,4- triazolyls or 1,2,5- thiadiazolyl groups：Fluorine, chlorine, bromine, cyano group, nitro, C₁-C₄Alkyl (which is optionally replaced by fluorine and/or chlorine), C₁-C₃Alkyl sulfenyl (which is optionally replaced by fluorine and/or chlorine) or C₁-C₃Alkyl sulphur Acyl group (which is optionally replaced by fluorine and/or chlorine),

Or

A represents group

Wherein

X represents halogen, alkyl or haloalkyl,

Y represents halogen, alkyl, haloalkyl, halogenated alkoxy, azido or cyano group, and

R¹Represent alkyl, haloalkyl, thiazolinyl, haloalkenyl group, alkynyl, cycloalkyl, cycloalkyl-alkyl, halogenated cycloalkyl, Alkoxyl, alkoxyalkyl or halogenated cycloalkyl alkyl.

Furthermore it is known that selected from some activity of chitin synthesis inhibitor class, ecdysone agonist class or other classifications Compound have kill insecticide and mite killing worm characteristic.These compounds have been disclosed in disclosed patent specification and scientific publications In.Selected from the insecticidal compounds as herein described of chitin synthesis inhibitor class, ecdysone agonist class or other classifications It is commercially available as the independent reactive compound in the compositionss of preventing and treating animal pests.These compounds and compositionss are It is described in handbook such as " The Pesticide Manual, 14th edition, C.D.S.Thomlin (Ed.), British In Crop Protection Council, Surrey, UK, 2006 ", by which with regard to being selected from chitin synthesis inhibitor class, casting off a skin The major part of the reactive compound disclosed herein of Hormone agonists class or other classifications includes this explanation by reference Book.Neither reactive compound that is commercially available and being not listed in " Pesticide Manual " is by No. IUPAC and/or structural formula Mark.

The Pesticidal compound of formula (I) or selected from chitin synthesis inhibitor, ecdysone agonist or other classifications The activity of reactive compound is generally very well.However, in the case of particularly in low rate of application and for some insects, they can not Always meet the requirement of agricultural practice, therefore there is still a need for not only have high economics efficiency but also the Pest control of ecological safety.

Pesticidal compound other are required to include：Reduce close rate；Significantly widen can pest control scope, including Resistant insect；Improve safety in utilization；Reduce phytotoxicity and thereby improve plant tolerance；Prevent and treat the evil of different developmental phases Worm；Improve the performance during Pesticidal compound preparation process (such as grinding or mixed process), its storage process or its use； Even if also there is extremely favourable biocidal spectrum, while with good warm-blooded organisms, fish and Plant Tolerance under low concentration rate Property；And obtain additive effect (additional effect), such as algae removal, anthelmintic, kill bird, bactericidal, antifungal, kill soft Body animal, nematicide, plant activate, kill rodent or the effect of killing the virus.

Other particular requirements to being ready to use in the Pesticidal compound of asexual and sexual plant propagating materialss include being applied to When seed and plant propagation material, the compatibility of insignificant phytotoxicity and edaphic condition is (such as with regard to compound and soil With reference to for), the absorbability of plant activity, rudiment is had no adverse effect and the drug effect in the pests live cycle.

The content of the invention

The purpose of the present invention is to meet one or more in above-mentioned requirements, and the requirement for example reduces close rate, widens Can pest control (include resistant insect) scope and the specific of property is applied to asexual and sexual plant propagating materialss particularly Require.

Having now found that at least one formula (I) compound --- condition is not include 4- { [(6- chloropyridine -3- bases) methyl] (methyl) amino } -2 (5H) -one of furan and 4- { [(6- chloropyridine -3- bases) methyl] (cyclopropyl) amino } furan -2 (5H) - Ketone --- and it is at least one selected from it is following list one by one from chitin synthesis inhibitor class, ecdysone agonist class or its The conjugate of the compound of the reactive compound 1 to 22 of its classification has synergistic activity and is suitable to prevent and treat animal pests.

Especially, can be mentioned that below chitin synthesis inhibitor class, ecdysone agonist class or other classifications Compound 1 to 22：

A) benzoylurea derivertives class, such as benzoyl area kind, such as

1. chlorfluazuron (chlorfluazuron) (being known in DE-A 28 18 830)

2. diflubenzuron (diflubenzuron) (being known in DE-A 21 23 236)

3. lufenuron (lufenuron) (being known in EP-A 0 179 022)

4. fluorobenzene urea (teflubenzuron) (being known in EP-A 0 052 833)

5. triflumuron (triflumuron) (being known in DE-A 26 01 780)

6. novaluron (novaluron) (being known in US 4,980,376)

7. HEXAFLUMURON (hexaflumuron) (being known in EP-A 0 071 279)

8. bistrifluron (bistrifluron) (DBI-3204) (is known in WO 98/00394)

9. Cascade (flufenoxuron) (being known in EP-A 0 161 019)

10. flucycloxuron (flucycloxuron) (be known in P.Scheltes, T.W.Hofman, A.C.Grosscurt, BCPC Conf.Pests Dis.1988,2,559-666、EP-A 00117320)

11. noviflumurons (noviflumuron) (are known in WO 9819542A1,1998)

12. fluazurons (fluazuron) (are known in EP-A 00079311)

B) benzoylurea derivertives class, for example

13. Buprofezins (buprofezin) (it is known in Proc.Br.Crop Prot.Conf.-Pests Dis., 1981, 1,59)

C) cast off a skin agent interfering class, for example

14. cyromazines (cyromazine) (are known in GB-A 1 587 573)

D) juvenile hormone mimics class, for example

15. Nylar (pyriproxifen) (is known in GB-A 2 140 010)

16. difenolans (diofenolan) (are known in DE 2 655 910)

17. fenoxycarbs (fenoxycarb) (are known in EP 0 004 334)

E) ecdysone agonist class, such as diacyl hydrazine, such as

18. tebufenozides (tebufenozide) (are known in US 4,985,461)

19. methoxyfenozides (methoxyfenozide) (are known in US 5,344,958)

20. ring tebufenozides (chromafenozide) (are known in EP 00496342)

21. chlorine tebufenozides (halofenozide) (are known in EP 228 564)

22.2,3- dihydro -2,7- dimethyl -6- benzofurancarboxylic acid 2- (3,5- dimethylbenzoyls) -2- (1,1- bis- Methylethyl) hydrazides (JS 118) (being known in CN-Pat.1313276)

Astoundingly, active agent combinations of the present invention kill insecticide and acaricidal action substantially exceeds single activation The summation of compound effect.Presence also fails to the real cooperative effect for expecting, and is not only the complementation of effect.

Formula (I) compound and the activity from chitin synthesis inhibitor class, ecdysone agonist class or other classifications The synergism of the active agent combinations of the present invention of compound is mainly by reducing close rate and widen can pest control Scope and widened formula (I) compound and from chitin synthesis inhibitor class, ecdysone agonist class or other classifications The sphere of action of reactive compound.Therefore, by using formula (I) compound and from chitin synthesis inhibitor class, cast off a skin sharp The active agent combinations of the present invention of the reactive compound of plain agonist class or other classifications, even if in active ingredient of the present invention When the single compound of combination is used under low rate of application in the case of activity deficiency, the insect that can still obtain height prevents Control.

In addition to above-mentioned synergism, the active agent combinations of the present invention can be shown that other are wonderful excellent Gesture, which includes：Improve safety in utilization；Reduce phytotoxicity and thereby improve plant tolerance；Prevent and treat different developmental phases Insect；Property during optimization Pesticidal compound preparation process (such as grinding or mixed process), its storage process or its use Energy；Even if also there is extremely favourable biocidal spectrum at low concentrations, while with good warm-blooded organisms, fish and Plant Tolerance Property；And obtain additive effect, such as algae removal, anthelmintic, kill bird, bactericidal, antifungal, kill Mollusca, nematicide, plant live Change, kill rodent or the effect of killing the virus.

Additionally, astoundingly, it has been found that the present invention active agent combinations be particularly suitable for protect seed and/or by Seed growth into plant seedling and leaf from insect damage.For example, active agent combinations of the invention are with applying The compatibility for inappreciable phytotoxicity and edaphic condition during plant propagation material is (such as with regard to compound and soil With reference to for), the absorbability of plant activity, rudiment is had no adverse effect and the drug effect in the pests live cycle.

In addition at least one formula (I) compound, active agent combinations of the present invention also include closing from chitin Into in the reactive compound 1 to 22 listed one by one above of inhibitor class, ecdysone agonist class or other classifications at least It is a kind of.Active agent combinations of the present invention preferably include a kind of lucky formula (I) compound and suppress from chitin synthesis Lucky one kind in the reactive compound 1 to 22 listed one by one above of agent class, ecdysone agonist class or other classifications.Also Preferably include a kind of formula (I) compound and from chitin synthesis inhibitor class, ecdysone agonist class or other classifications Two kinds of active agent combinations in the reactive compound 1 to 22 listed one by one above.Further preferably include two kinds of formula (I) chemical combination Thing and the active ingredient listed one by one above from chitin synthesis inhibitor class, ecdysone agonist class or other classifications A kind of mixture in thing 1 to 22.

Specific embodiment

Be listed below with from chitin synthesis inhibitor class, ecdysone agonist class or other classifications above Above-mentioned formula (I) chemical combination in the active agent combinations of the present invention of at least one of the reactive compound 1 to 22 listed one by one The preferred subgroup (sub-group) of thing, condition are not include 4- { [(6- chloropyridine -3- bases) methyl] (methyl) amino } furan -2 (5H) -one and 4- { [(6- chloropyridine -3- bases) methyl] (cyclopropyl) amino } furan -2 (5H) -one.

A preferably represent 6- fluorine pyridin-3-yls, 6- chloropyridine -3- bases, 6- bromopyridine -3- bases, 6- picoline -3- bases, The chloro- 1,4- pyridazines -3- bases of 6- trifluoromethyl pyridine -3- bases, 6- trifluoromethoxy pyridin-3-yls, 6-, 6- methyl isophthalic acids, 4- pyridazines - The chloro- 1,3- thiazoles -5- bases of 3- bases, 2- or 2- methyl-1,3-thiazole -5- bases, 2- chloropyrimide -5- bases, 2- trifluoromethyl pyrimidine -5- Base, 5,6- difluoro pyridine -3- bases, the chloro- 6- fluorine pyridin-3-yls of 5-, the bromo- 6- fluorine pyridin-3-yls of 5-, the iodo- 6- fluorine pyridine -3- of 5- The fluoro- 6- chloropyridines -3- bases of base, 5-, 5,6- dichloropyridine -3- bases, the bromo- 6- chloropyridines -3- bases of 5-, the iodo- 6- chloropyridines -3- of 5- The fluoro- 6- bromopyridines -3- bases of base, 5-, the chloro- 6- bromopyridines -3- bases of 5-, bis- bromo- pyridin-3-yls of 5,6-, the fluoro- 6- iodine pyridines -3- of 5- The chloro- 6- iodine pyridines -3- bases of base, 5-, the bromo- 6- iodine pyridines -3- bases of 5-, 5- methyl -6- fluorine pyridin-3-yls, 5- methyl -6- chlorine pyrroles Pyridine -3- bases, 5- methyl -6- bromopyridine -3- bases, 5- methyl -6- iodine pyridine -3- bases, 5- difluoromethyl -6- fluorine pyridin-3-yls, 5- Difluoromethyl -6- chloropyridine -3- bases, 5- difluoromethyl -6- bromopyridine -3- bases or 5- difluoromethyl -6- iodine pyridine -3- bases.

R¹The C for optionally being replaced by fluorine is represented preferably₁-C₅Alkyl, C₂-C₅Thiazolinyl, C₃-C₅Cycloalkyl, C₃-C₅Cycloalkyl Alkyl or C₁-C₅Alkoxyl.

A particularly preferably represents 6- fluorine pyridin-3-yls, 6- chloropyridine -3- bases, 6- bromopyridine -3- bases, the chloro- 1,4- of 6- and rattles away The chloro- 1,3- thiazoles -5- bases of piperazine -3- bases, 2-, 2- chloropyrimide -5- bases, the fluoro- 6- chloropyridines -3- bases of 5-, 5,6- dichloropyridine -3- The bromo- 6- chloropyridines -3- bases of base, 5-, the fluoro- 6- bromopyridines -3- bases of 5-, the chloro- 6- bromopyridines -3- bases of 5-, 5,6- dibromo pyridine -3- Base, 5- methyl -6- chloropyridine -3- bases, the chloro- 6- iodine pyridines -3- bases of 5- or 5- difluoromethyl -6- chloropyridine -3- base groups.

R¹Methyl, methoxyl group, ethyl, propyl group, vinyl, pi-allyl, propargyl, cyclopropyl, 2- are represented particularly preferably Fluoro ethyl, bis- fluoro ethyls of 2,2- or 2- fluorine cyclopropyl.

A very particularly preferably represents 6- fluorine pyridin-3-yls, 6- chloropyridine -3- bases, 6- bromopyridine -3- bases, the fluoro- 6- chlorine of 5- The chloro- 1,3- thiazoles -5- bases of pyridin-3-yl, 2- or 5,6- dichloropyridine -3- base groups.

R¹Methyl, cyclopropyl, methoxyl group, bis- fluoro ethyl of 2- fluoro ethyls or 2,2- are represented very particularly preferably.

A most preferably represents 6- chloropyridine -3- bases or the fluoro- 6- chloropyridines -3- base groups of 5-.

R¹Methyl, bis- fluoro ethyl of 2- fluoro ethyls or 2,2- are represented most preferably.

In one group of specific formula (I) compound, A represents 6- chloropyridine -3- bases.

In another group of specific formula (I) compound, A represents 6- bromopyridine -3- bases.

In another group of specific formula (I) compound, A represents the chloro- Isosorbide-5-Nitraes of 6--pyridazine -3- bases.

In another group of specific formula (I) compound, A represents the chloro- 1,3-thiazoles -5- bases of 2-.

In another group of specific formula (I) compound, A represents the fluoro- 6- chloropyridines -3- bases of 5-.

In another group of specific formula (I) compound, A represents the fluoro- 6- bromopyridines -3- bases of 5-.

In another group of specific formula (I) compound, A represents 5,6- dichloropyridine -3- bases.

In another group of specific formula (I) compound, R¹Represent methyl.

In another group of specific formula (I) compound, R¹Represent ethyl.

In another group of specific formula (I) compound, R¹Represent cyclopropyl.

In another group of specific formula (I) compound, R¹Represent 2- fluoro ethyls.

In another group of specific formula (I) compound, R¹Represent bis- fluoro ethyls of 2,2-.

Above-mentioned wide in range or preferred group definition is illustrated and can be bonded to each other as needed, i.e., including each preferred scope Between combination.

Present invention preferably comprises formula (I) compound of the above as the combination of preferably listed implication.

It is specifically preferred according to the invention including more than as the implication listed by particularly preferably combination formula (I) compound.

The present invention extremely particularly preferably includes formula (I) compound of combination above as extremely particularly preferably listed implication.

Formula (I) compound of one preferred subgroup is those of formula (I-a)

Wherein

B represents pyridine -2- bases or pyridin-4-yl, or represents on 6- positions optionally by the pyridine -3- of following substituent group Base：Fluorine, chlorine, bromine, methyl, trifluoromethyl or trifluoromethoxy, or represent on 6- positions optionally by chlorine or methyl substituted rattle away Piperazine -3- bases, or pyrazine -3- bases are represented, or 2- chloropyrazine -5- bases are represented, or representative is optionally taken by chlorine or methyl on 2- positions 1,3-thiazoles -5- the bases in generation,

R²Represent haloalkyl, haloalkenyl group, halogenated cycloalkyl or halogenated cycloalkyl alkyl.

The preferred substituents or examples of ranges of group mentioned in shown formula (I-a) are described as follows above and below：

B preferably represent 6- fluorine pyridin-3-yls, 6- chloropyridine -3- bases, 6- bromopyridine -3- bases, 6- picoline -3- bases, The chloro- 1,4- pyridazines -3- bases of 6- trifluoromethyl pyridine -3- bases, 6- trifluoromethoxy pyridin-3-yls, 6-, 6- methyl isophthalic acids, 4- pyridazines - The chloro- 1,3- thiazoles -5- bases of 3- bases, 2- or 2- methyl-1,3-thiazole -5- bases.

R²The C replaced by fluorine is represented preferably₁-C₅Alkyl, C₂-C₅Thiazolinyl, C₃-C₅Cycloalkyl or C₃-C₅Cycloalkyl-alkyl.

B particularly preferably represents 6- fluorine pyridin-3-yls, 6- chloropyridine -3- bases, 6- bromopyridine -3- bases, the chloro- 1,4- of 6- and rattles away The chloro- 1,3- thiazoles -5- base groups of piperazine -3- bases, 2-.

R²2- fluoro ethyls, bis- fluoro ethyls of 2,2-, 2- fluorine cyclopropyl are represented particularly preferably.

B very particularly preferably represents 6- chloropyridine -3- base groups.

R²Bis- fluoro ethyl of 2- fluoro ethyls or 2,2- is represented very particularly preferably.

In one group of specific formula (I-a) compound, B represents 6- chloropyridine -3- bases.

In another group of specific formula (I-a) compound, B represents 6- bromopyridine -3- bases.

In another group of specific formula (I-a) compound, B represents the chloro- Isosorbide-5-Nitraes of 6--pyridazine -3- bases.

In another group of specific formula (I-a) compound, R²Represent 2- fluoro ethyls.

In another group of specific formula (I-a) compound, R²Represent bis- fluoro ethyls of 2,2-.

Formula (I) compound of another preferred subgroup is those of formula (I-b)

Wherein

D represents group

Wherein

X and Y have implication given above,

R³Represent hydrogen, alkyl, thiazolinyl, alkynyl, cycloalkyl or alkoxyl.

The preferred substituents or examples of ranges of group mentioned in shown formula (I-b) are described as follows above and below：

D preferably represents one of following group：5,6- difluoro pyridine -3- bases, the chloro- 6- fluorine pyridin-3-yls of 5-, the bromo- 6- of 5- The fluoro- 6- chloropyridines -3- bases of the iodo- 6- fluorine pyridin-3-yl of fluorine pyridin-3-yl, 5-, 5-, 5,6- dichloropyridine -3- bases, the bromo- 6- chlorine of 5- The iodo- 6- chloropyridines -3- bases of pyridin-3-yl, 5-, the fluoro- 6- bromopyridines -3- bases of 5-, the chloro- 6- bromopyridines -3- bases of 5-, 5,6- dibromo pyrroles The fluoro- 6- iodine pyridines -3- bases of pyridine -3- bases, 5-, the chloro- 6- iodine pyridines -3- bases of 5-, the bromo- 6- iodine pyridines -3- bases of 5-, 5- methyl -6- fluorine Pyridin-3-yl, 5- methyl -6- chloropyridine -3- bases, 5- methyl -6- bromopyridine -3- bases, 5- methyl -6- iodine pyridine -3- bases, 5- bis- Methyl fluoride -6- fluorine pyridin-3-yls, 5- difluoromethyl -6- chloropyridine -3- bases, 5- difluoromethyl -6- bromopyridine -3- bases, 5- difluoros Methyl -6- iodine pyridine -3- bases.

R³C is represented preferably₁-C₄Alkyl, C₂-C₄Thiazolinyl, C₂-C₄Alkynyl or C₃-C₄Cycloalkyl.

D particularly preferably represents the fluoro- 6- chloropyridines -3- bases of 5-, 5,6- dichloropyridine -3- bases, the bromo- 6- chloropyridines -3- of 5- The fluoro- 6- bromopyridines -3- bases of base, 5-, the chloro- 6- bromopyridines -3- bases of 5-, 5,6- dibromo pyridine -3- bases, 5- methyl -6- chloropyridine -3- The chloro- 6- iodine pyridines -3- bases of base, 5- or 5- difluoromethyl -6- chloropyridine -3- bases.

R³C is represented particularly preferably₁-C₄Alkyl.

D very particularly preferably represents the fluoro- 6- chloropyridines -3- bases of 5- or the fluoro- 6- bromopyridines -3- bases of 5-.

R³Methyl, ethyl, propyl group, vinyl, pi-allyl, propargyl or cyclopropyl are represented very particularly preferably.

D most preferably represents the fluoro- 6- chloropyridines -3- bases of 5-.

R³Methyl or cyclopropyl are represented most preferably.

In another group of specific formula (I-b) compound, D represents the fluoro- 6- chloropyridines -3- bases of 5-.

In another group of specific formula (I-b) compound, D represents 5,6- dichloropyridine -3- bases.

In another group of specific formula (I-b) compound, D represents the bromo- 6- chloropyridines -3- bases of 5-.

In another group of specific formula (I-b) compound, D represents 5- methyl -6- chloropyridine -3- bases.

In another group of specific formula (I-b) compound, D represents the fluoro- 6- bromopyridines -3- bases of 5-.

In another group of specific formula (I-b) compound, D represents the chloro- 6- bromopyridines -3- bases of 5-.

In another group of specific formula (I-b) compound, D represents the chloro- 6- iodine pyridines -3- bases of 5-.

In another group of specific formula (I-b) compound, R³Represent methyl.

In another group of specific formula (I-b) compound, R³Represent ethyl.

In another group of specific formula (I-b) compound, R³Represent cyclopropyl.

Formula (I) compound of another preferred subgroup is those of formula (I-c)

Wherein

E represents group

Wherein

X and Y have implication given above, and

R⁴Represent haloalkyl, haloalkenyl group, halogenated cycloalkyl or halogenated cycloalkyl alkyl.

The preferred substituents or examples of ranges of group mentioned in shown formula (I-c) are described as follows above and below：

E preferably represents one of following group：5,6- difluoro pyridine -3- bases, the chloro- 6- fluorine pyridin-3-yls of 5-, the bromo- 6- of 5- The fluoro- 6- chloropyridines -3- bases of the iodo- 6- fluorine pyridin-3-yl of fluorine pyridin-3-yl, 5-, 5-, 5,6- dichloropyridine -3- bases, the bromo- 6- chlorine of 5- The iodo- 6- chloropyridines -3- bases of pyridin-3-yl, 5-, the fluoro- 6- bromopyridines -3- bases of 5-, the chloro- 6- bromopyridines -3- bases of 5-, 5,6- dibromo pyrroles The fluoro- 6- iodine pyridines -3- bases of pyridine -3- bases, 5-, the chloro- 6- iodine pyridines -3- bases of 5-, the bromo- 6- iodine pyridines -3- bases of 5-, 5- methyl -6- fluorine Pyridin-3-yl, 5- methyl -6- chloropyridine -3- bases, 5- methyl -6- bromopyridine -3- bases, 5- methyl -6- iodine pyridine -3- bases, 5- bis- Methyl fluoride -6- fluorine pyridin-3-yls, 5- difluoromethyl -6- chloropyridine -3- bases, 5- difluoromethyl -6- bromopyridine -3- bases, 5- difluoros Methyl -6- iodine pyridine -3- bases.

R⁴The C replaced by fluorine is represented preferably₁-C₅Alkyl, C₂-C₅Thiazolinyl, C₃-C₅Cycloalkyl or C₃-C₅Cycloalkyl-alkyl.

E particularly preferably represents the fluoro- 6- chloropyridines -3- bases of 2- chloropyrimide -5- bases, 5-, 5,6- dichloropyridine -3- bases, 5- The fluoro- 6- bromopyridines -3- bases of bromo- 6- chloropyridines -3- bases, 5-, the chloro- 6- bromopyridines -3- bases of 5-, 5,6- dibromo pyridine -3- bases, 5- first Base -6- chloropyridine -3- bases, the chloro- 6- iodine pyridines -3- bases of 5- or 5- difluoromethyl -6- chloropyridine -3- bases.

R⁴2- fluoro ethyls, bis- fluoro ethyls of 2,2-, 2- fluorine cyclopropyl are represented particularly preferably.

E very particularly preferably represents the fluoro- 6- chloropyridines -3- bases of 5-.

R⁴Bis- fluoro ethyl of 2- fluoro ethyls or 2,2- is represented very particularly preferably.

In another group of specific formula (I-c) compound, E represents the fluoro- 6- chloropyridines -3- bases of 5-.

In another group of specific formula (I-c) compound, E represents 5,6- dichloropyridine -3- bases.

In another group of specific formula (I-c) compound, E represents the bromo- 6- chloropyridines -3- bases of 5-.

In another group of specific formula (I-c) compound, E represents 5- methyl -6- chloropyridine -3- bases.

In another group of specific formula (I-c) compound, E represents the fluoro- 6- bromopyridines -3- bases of 5-.

In another group of specific formula (I-c) compound, E represents the chloro- 6- bromopyridines -3- bases of 5-.

In another group of specific formula (I-c) compound, E represents the chloro- 6- iodine pyridines -3- bases of 5-.

In another group of specific formula (I-c) compound, R⁴Represent 2- fluoro ethyls.

In another group of specific formula (I-c) compound, R⁴Represent bis- fluoro ethyls of 2,2-.

Formula (I) compound of one preferred subgroup is those of formula (I-d)

Wherein

G represents pyridine -2- bases or pyridin-4-yl, or represents on 6- positions optionally by the pyridine -3- of following substituent group Base：Fluorine, chlorine, bromine, methyl, trifluoromethyl or trifluoromethoxy, or represent on 6- positions optionally by chlorine or methyl substituted rattle away Piperazine -3- bases, or pyrazine -3- bases are represented, or 2- chloropyrazine -5- bases are represented, or representative is optionally taken by chlorine or methyl on 2- positions 1,3-thiazoles -5- the bases in generation, and

R⁵Represent C₁-C₄Alkyl, C₂-C₄Thiazolinyl, C₂-C₄Alkynyl, C₃-C₄Cycloalkyl or C₁-C₄Alkoxyl,

Condition is not include 4- { [(6- chloropyridine -3- bases) methyl] (methyl) amino } -2 (5H) -one of furan and 4- { [(6- Chloropyridine -3- bases) methyl] (cyclopropyl) amino } furan -2 (5H) -one.

The preferred substituents or examples of ranges of group mentioned in shown formula (I-d) are described as follows above and below：

G preferably represent 6- fluorine pyridin-3-yls, 6- chloropyridine -3- bases, 6- bromopyridine -3- bases, 6- picoline -3- bases, The chloro- 1,4- pyridazines -3- bases of 6- trifluoromethyl pyridine -3- bases, 6- trifluoromethoxy pyridin-3-yls, 6-, 6- methyl isophthalic acids, 4- pyridazines - The chloro- 1,3- thiazoles -5- bases of 3- bases, 2- or 2- methyl-1,3-thiazole -5- bases.

R⁵C is represented preferably₁-C₄Alkyl, C₁Alkoxyl, C₂-C₄Thiazolinyl, C₂-C₄Alkynyl or C₃-C₄Cycloalkyl.

G particularly preferably represents 6- fluorine pyridin-3-yls, 6- chloropyridine -3- bases, 6- bromopyridine -3- bases, the chloro- 1,4- of 6- and rattles away The chloro- 1,3- thiazoles -5- base groups of piperazine -3- bases, 2-.

R⁵Methyl, methoxyl group, ethyl, propyl group, vinyl, pi-allyl, propargyl or cyclopropyl are represented particularly preferably.

G very particularly preferably represents 6- chloropyridine -3- base groups.

R⁵Methyl or cyclopropyl are represented very particularly preferably.

In one group of specific formula (I-d) compound, G represents 6- chloropyridine -3- bases.

In another group of specific formula (I-d) compound, G represents 6- bromopyridine -3- bases.

In another group of specific formula (I-d) compound, G represents the chloro- Isosorbide-5-Nitraes of 6--pyridazine -3- bases.

In another group of specific formula (I-d) compound, G represents the chloro- 1,3-thiazoles -5- bases of 2-.

In another group of specific formula (I-d) compound, G represents 6- fluorine pyridin-3-yls.

In another group of specific formula (I-d) compound, G represents 6- trifluoromethyl pyridine -3- bases.

In another group of specific formula (I-d) compound, R⁵Represent methyl.

In another group of specific formula (I-d) compound, R⁵Represent cyclopropyl.

Can specifically mentioned below general formula (I) compound：

● compound (I-1), 4- { [(6- bromopyridine -3- bases) methyl] (2- fluoro ethyls) amino } furan -2 (5H) -one, tool There is following formula

And it is known in 2007/115644 A1 of WO.

● compound (I-2), 4- { [(6- fluorine pyridin-3-yls) methyl] (2,2- bis- fluoro ethyl) amino } furan -2 (5H) - Ketone, with following formula

And it is known in 2007/115644 A1 of WO.

● compound (I-3), 4- { [(the chloro- 1,3-thiazoles -5- bases of 2-) methyl] (2- fluoro ethyls) amino } furan -2 (5H) - Ketone, with following formula

And it is known in 2007/115644 A1 of WO.

● compound (I-4), 4- { [(6- chloropyridine -3- bases) methyl] (2- fluoro ethyls) amino } furan -2 (5H) -one, tool There is following formula

And it is known in 2007/115644 A1 of WO.

● compound (I-5), 4- { [(6- chloropyridine -3- bases) methyl] (2,2- bis- fluoro ethyl) amino } furan -2 (5H) - Ketone, with following formula

And it is known in 2007/115644 A1 of WO.

● compound (I-6), 4- { [(the chloro- 5- fluorine pyridin-3-yls of 6-) methyl] (methyl) amino } furan -2 (5H) -one, With following formula

And it is known in 2007/115643 A1 of WO.

● compound (I-7), 4- { [(5,6- dichloropyridine -3- bases) methyl] (2- fluoro ethyls) amino } furan -2 (5H) - Ketone, with following formula

And it is known in 2007/115646 A1 of WO.

● compound (I-8), 4- { [(the chloro- 5- fluorine pyridin-3-yls of 6-) methyl] (cyclopropyl) amino } furan -2 (5H) - Ketone, with following formula

And it is known in 2007/115643 A1 of WO.

The active agent combinations of the present invention preferably include at least one selected from formula (I-a) illustrated above, (I- B), formula (I) compound of (I-c) and (I-d) compound --- condition is not include 4- { [(6- chloropyridine -3- bases) methyl] (first Base) amino } -2 (5H) -one of furan and 4- { [(6- chloropyridine -3- bases) methyl] (cyclopropyl) amino } furan -2 (5H) -one --- With the reactive compound listed one by one above from chitin synthesis inhibitor class, ecdysone agonist class or other classifications One kind in 1 to 22.

The active agent combinations of the present invention preferably include at least one selected from formula (I-a) illustrated above, (I- B) with formula (I) compound of (I-c) compound and from chitin synthesis inhibitor class, ecdysone agonist class or other classes One kind in other reactive compound 1 to 22 listed one by one above.

It is particularly preferred that the active agent combinations of the present invention include that (wherein A is selected from least one formula (I) compound Group 6- fluorine pyridin-3-yls, 6- chloropyridine -3- bases, 6- bromopyridine -3- bases, the fluoro- 6- chloropyridines -3- bases of 5-, the chloro- 1,3- thiophenes of 2- Azoles -5- bases and 5,6- dichloropyridine -3- bases, and R¹Selected from group methyl, cyclopropyl, methoxyl group, 2- fluoro ethyls and 2,2- difluoros Ethyl) --- condition is not include 4- { [(6- chloropyridine -3- bases) methyl] (methyl) amino } -2 (5H) -one of furan and 4- { [(6- chloropyridine -3- bases) methyl] (cyclopropyl) amino } furan -2 (5H) -one --- and from chitin synthesis inhibitor class, One kind in the reactive compound 1 to 22 listed one by one above of ecdysone agonist class or other classifications.

Very particularly preferably, active agent combinations of the invention include at least one selected from formula (I- illustrated above 1), formula (I) compound of (I-2), (I-3), (I-4), (I-5), (I-6), (I-7) and (I-8) compound, and from chitin In the reactive compound 1 to 22 listed one by one above of synthetic inhibitor class, ecdysone agonist class or other classifications one Kind.

Listed conjugate in table 1 is these gived, wherein each conjugate itself is of the invention a kind of extremely particularly preferred Embodiment.

Table 1

Additionally, conjugate listed in obtaining table 2, wherein each conjugate itself is one kind side of being preferable to carry out of the present invention Case.

Table 2

Additionally, conjugate listed in obtaining table 3, wherein each conjugate itself is one kind side of being preferable to carry out of the present invention Case.

Table 3

Additionally, conjugate listed in obtaining table 4, wherein each conjugate itself is one kind side of being preferable to carry out of the present invention Case.

Table 4

Additionally, conjugate listed in obtaining table 5, wherein each conjugate itself is one kind side of being preferable to carry out of the present invention Case.

Table 5

Additionally, conjugate listed in obtaining table 6, wherein each conjugate itself is one kind side of being preferable to carry out of the present invention Case.

Table 6

Additionally, conjugate listed in obtaining table 7, wherein each conjugate itself is one kind side of being preferable to carry out of the present invention Case.

Table 7

Additionally, conjugate listed in obtaining table 8, wherein each conjugate itself is one kind side of being preferable to carry out of the present invention Case.

Table 8

If reactive compound is present with certain weight ratio in active agent combinations of the present invention, cooperative effect is special It is not notable.However, the weight ratio of reactive compound can change in relatively wide scope in active agent combinations.It is logical Often, conjugate of the present invention is with the following reactive compound for preferably including formula (I) with particularly preferred mixing ratio and from chitin In the reactive compound 1 to 22 listed one by one above of synthetic inhibitor class, ecdysone agonist class or other classifications one Kind：

Preferred mixing ratio：125:1 to 1:125

Particularly preferred mixing ratio：25:1 to 1:25

The mixing ratio is based on weight ratio meter.The ratio is understood to mean that formula (I) compound：Reactive compound 1 to 22.

Formula (I) compound with from chitin synthesis inhibitor class, ecdysone agonist class or other classifications above Other a kind of mixing ratios in listed reactive compound 1 to 22 are illustrated in lower and by mixing ratio preference degree one by one Cumulative arrangement：95:1 to 1:95、95:1 to 1:90、95:1 to 1:85、95:1 to 1:80、95:1 to 1:75、95:1 to 1:70、 95:1 to 1:65、95:1 to 1:60、95:1 to 1:55、95:1 to 1:50、95:1 to 1:45、95:1 to 1:40、95:1 to 1:35、 95:1 to 1:30、95:1 to 1:25、95:1 to 1:20、95:1 to 1:15、95:1 to 1:10、95:1 to 1:5、95:1 to 1:4、 95:1 to 1:3、95:1 to 1:2、90:1 to 1:90、90:1 to 1:95、90:1 to 1:85、90:1 to 1:80、90:1 to 1:75、 90:1 to 1:70、90:1 to 1:65、90:1 to 1:60、90:1 to 1:55、90:1 to 1:50、90:1 to 1:45、90:1 to 1:40、 90:1 to 1:35、90:1 to 1:30、90:1 to 1:25、90:1 to 1:20、90:1 to 1:15、90:1 to 1:10、90:1 to 1:5、 90:1 to 1:4、90:1 to 1:3、90:1 to 1:2、85:1 to 1:85、85:1 to 1:95、85:1 to 1:90、85:1 to 1:80、85: 1 to 1:75、85:1 to 1:70、85:1 to 1:65、85:1 to 1:60、85:1 to 1:55、85:1 to 1:50、85:1 to 1:45、85: 1 to 1:40、85:1 to 1:35、85:1 to 1:30、85:1 to 1:25、85:1 to 1:20、85:1 to 1:15、85:1 to 1:10、85: 1 to 1:5、85:1 to 1:4、85:1 to 1:3、85:1 to 1:2、80:1 to 1:80、80:1 to 1:95、80:1 to 1:90、80:1 to 1:85、80:1 to 1:75、80:1 to 1:70、80:1 to 1:65、80:1 to 1:60、80:1 to 1:55、80:1 to 1:50、80:1 to 1:45、80:1 to 1:40、80:1 to 1:35、80:1 to 1:30、80:1 to 1:25、80:1 to 1:20、80:1 to 1:15、80:1 to 1:10、80:1 to 1:5、80:1 to 1:4、80:1 to 1:3、80:1 to 1:2、75:1 to 1:75、75:1 to 1:95、75:1 to 1: 90、75:1 to 1:85、75:1 to 1:80、75:1 to 1:70、75:1 to 1:65、75:1 to 1:60、75:1 to 1:55、75:1 to 1: 50、75:1 to 1:45、75:1 to 1:40、75:1 to 1:35、75:1 to 1:30、75:1 to 1:25、75:1 to 1:20、75:1 to 1: 15、75:1 to 1:10、75:1 to 1:5、75:1 to 1:4、75:1 to 1:3、75:1 to 1:2、70:1 to 1:70、70:1 to 1:95、 70:1 to 1:90、70:1 to 1:85、70:1 to 1:80、70:1 to 1:75、70:1 to 1:65、70:1 to 1:60、70:1 to 1:55、 70:1 to 1:50、70:1 to 1:45、70:1 to 1:40、70:1 to 1:35、70:1 to 1:30、70:1 to 1:25、70:1 to 1:20、 70:1 to 1:15、70:1 to 1:10、70:1 to 1:5、70:1 to 1:4、70:1 to 1:3、70:1 to 1:2、65:1 to 1:65、65:1 To 1:95、65:1 to 1:90、65:1 to 1:85、65:1 to 1:80、65:1 to 1:75、65:1 to 1:70、65:1 to 1:60、65:1 To 1:55、65:1 to 1:50、65:1 to 1:45、65:1 to 1:40、65:1 to 1:35、65:1 to 1:30、65:1 to 1:25、65:1 To 1:20、65:1 to 1:15、65:1 to 1:10、65:1 to 1:5、65:1 to 1:4、65:1 to 1:3、65:1 to 1:2、60:1 to 1: 60、60:1 to 1:95、60:1 to 1:90、60:1 to 1:85、60:1 to 1:80、60:1 to 1:75、60:1 to 1:70、60:1 to 1: 65、60:1 to 1:55、60:1 to 1:50、60:1 to 1:45、60:1 to 1:40、60:1 to 1:35、60:1 to 1:30、60:1 to 1: 25、60:1 to 1:20、60:1 to 1:15、60:1 to 1:10、60:1 to 1:5、60:1 to 1:4、60:1 to 1:3、60:1 to 1:2、 55:1 to 1:55、55:1 to 1:95、55:1 to 1:90、55:1 to 1:85、55:1 to 1:80、55:1 to 1:75、55:1 to 1:70、 55:1 to 1:65、55:1 to 1:60、55:1 to 1:50、55:1 to 1:45、55:1 to 1:40、55:1 to 1:35、55:1 to 1:30、 55:1 to 1:25、55:1 to 1:20、55:1 to 1:15、55:1 to 1:10、55:1 to 1:5、55:1 to 1:4、55:1 to 1:3、55: 1 to 1:2、50:1 to 1:95、50:1 to 1:90、50:1 to 1:85、50:1 to 1:80、50:1 to 1:75、50:1 to 1:70、50:1 To 1:65、50:1 to 1:60、50:1 to 1:55、50:1 to 1:45、50:1 to 1:40、50:1 to 1:35、50:1 to 1:30、50:1 To 1:25、50:1 to 1:20、50:1 to 1:15、50:1 to 1:10、50:1 to 1:5、50:1 to 1:4、50:1 to 1:3、50:1 to 1:2、45:1 to 1:45、45:1 to 1:95、45:1 to 1:90、45:1 to 1:85、45:1 to 1:80、45:1 to 1:75、45:1 to 1:70、45:1 to 1:65、45:1 to 1:60、45:1 to 1:55、45:1 to 1:50、45:1 to 1:40、45:1 to 1:35、45:1 to 1:30、45:1 to 1:25、45:1 to 1:20、45:1 to 1:15、45:1 to 1:10、45:1 to 1:5、45:1 to 1:4、45:1 to 1: 3、45:1 to 1:2、40:1 to 1:40、40:1 to 1:95、40:1 to 1:90、40:1 to 1:85、40:1 to 1:80、40:1 to 1: 75、40:1 to 1:70、40:1 to 1:65、40:1 to 1:60、40:1 to 1:55、40:1 to 1:50、40:1 to 1:45、40:1 to 1: 35、40:1 to 1:30、40:1 to 1:25、40:1 to 1:20、40:1 to 1:15、40:1 to 1:10、40:1 to 1:5、40:1 to 1: 4、40:1 to 1:3、40:1 to 1:2、35:1 to 1:35、35:1 to 1:95、35:1 to 1:90、35:1 to 1:85、35:1 to 1:80、 35:1 to 1:75、35:1 to 1:70、35:1 to 1:65、35:1 to 1:60、35:1 to 1:55、35:1 to 1:50、35:1 to 1:45、 35:1 to 1:40、35:1 to 1:30、35:1 to 1:25、35:1 to 1:20、35:1 to 1:15、35:1 to 1:10、35:1 to 1:5、 35:1 to 1:4、35:1 to 1:3、35:1 to 1:2、30:1 to 1:30、30:1 to 1:95、30:1 to 1:90、30:1 to 1:85、30: 1 to 1:80、30:1 to 1:75、30:1 to 1:70、30:1 to 1:65、30:1 to 1:60、30:1 to 1:55、30:1 to 1:50、30: 1 to 1:45、30:1 to 1:40、30:1 to 1:35、30:1 to 1:25、30:1 to 1:20、30:1 to 1:15、30:1 to 1:10、30: 1 to 1:5、30:1 to 1:4、30:1 to 1:3、30:1 to 1:2、25:1 to 1:25、25:1 to 1:95、25:1 to 1:90、25:1 to 1:85、25:1 to 1:80、25:1 to 1:75、25:1 to 1:70、25:1 to 1:65、25:1 to 1:60、25:1 to 1:55、25:1 to 1:50、25:1 to 1:45、25:1 to 1:40、25:1 to 1:35、25:1 to 1:30、25:1 to 1:20、25:1 to 1:15、25:1 to 1:10、25:1 to 1:5、25:1 to 1:4、25:1 to 1:3、25:1 to 1:2、20:1 to 1:95、20:1 to 1:90、20:1 to 1: 85、20:1 to 1:80、20:1 to 1:75、20:1 to 1:70、20:1 to 1:65、20:1 to 1:60、20:1 to 1:55、20:1 to 1: 50、20:1 to 1:45、20:1 to 1:40、20:1 to 1:35、20:1 to 1:30、20:1 to 1:25、20:1 to 1:15、20:1 to 1: 10、20:1 to 1:5、20:1 to 1:4、20:1 to 1:3、20:1 to 1:2、15:1 to 1:15、15:1 to 1:95、15:1 to 1:90、 15:1 to 1:85、15:1 to 1:80、15:1 to 1:75、15:1 to 1:70、15:1 to 1:65、15:1 to 1:60、15:1 to 1:55、 15:1 to 1:50、15:1 to 1:45、15:1 to 1:40、15:1 to 1:35、15:1 to 1:30、15:1 to 1:25、15:1 to 1:20、 15:1 to 1:10、15:1 to 1:5、15:1 to 1:4、15:1 to 1:3、15:1 to 1:2、10:1 to 1:10、10:1 to 1:95、10:1 To 1:90、10:1 to 1:85、10:1 to 1:80、10:1 to 1:75、10:1 to 1:70、10:1 to 1:65、10:1 to 1:60、10:1 To 1:55、10:1 to 1:50、10:1 to 1:45、10:1 to 1:40、10:1 to 1:35、10:1 to 1:30、10:1 to 1:25、10:1 To 1:20、10:1 to 1:15、10:1 to 1:5、10:1 to 1:4、10:1 to 1:3、10:1 to 1:2、5:1 to 1:5、5:1 to 1:95、 5:1 to 1:90、5:1 to 1:85、5:1 to 1:80、5:1 to 1:75、5:1 to 1:70、5:1 to 1:65、5:1 to 1:60、5:1 to 1: 55、5:1 to 1:50、5:1 to 1:45、5:1 to 1:40、5:1 to 1:35、5:1 to 1:30、5:1 to 1:25、5:1 to 1:20、5:1 To 1:15、5:1 to 1:10、5:1 to 1:4、5:1 to 1:3、5:1 to 1:2、4:1 to 1:4、4:1 to 1:95、4:1 to 1:90、4:1 To 1:85、4:1 to 1:80、4:1 to 1:75、4:1 to 1:70、4:1 to 1:65、4:1 to 1:60、4:1 to 1:55、4:1 to 1:50、 4:1 to 1:45、4:1 to 1:40、4:1 to 1:35、4:1 to 1:30、4:1 to 1:25、4:1 to 1:20、4:1 to 1:15、4:1 to 1: 10、4:1 to 1:5、4:1 to 1:3、4:1 to 1:2、3:1 to 1:3、3:1 to 1:95、3:1 to 1:90、3:1 to 1:85、3:1 to 1: 80、3:1 to 1:75、3:1 to 1:70、3:1 to 1:65、3:1 to 1:60、3:1 to 1:55、3:1 to 1:50、3:1 to 1:45、3:1 To 1:40、3:1 to 1:35、3:1 to 1:30、3:1 to 1:25、3:1 to 1:20、3:1 to 1:15、3:1 to 1:10、3:1 to 1:5、 3:1 to 1:4、3:1 to 1:2、2:1 to 1:2、2:1 to 1:95、2:1 to 1:90、2:1 to 1:85、2:1 to 1:80、2:1 to 1:75、 2:1 to 1:70、2:1 to 1:65、2:1 to 1:60、2:1 to 1:55、2:1 to 1:50、2:1 to 1:45、2:1 to 1:40、2:1 to 1: 35、2:1 to 1:30、2:1 to 1:25、2:1 to 1:20、2:1 to 1:15、2:1 to 1:10、2:1 to 1:5、2:1 to 1:4、2:1 to 1:3。

Formula with least one basic center (I) compound or from chitin synthesis inhibitor class, ecdyson The reactive compound of agonist class or other classifications can form such as acid-addition salts, such as with following acid：Strong inorganic acid such as ore deposit Thing acid (mineral acid), such as perchloric acid, sulphuric acid, nitric acid, nitrous acid, phosphoric acid or halogen acids；Strong organic carboxyl acid, is not such as taken Generation or substituted (being for example optionally substituted by halogen) C₁-C₄Alkane carboxylic acid (such as acetic acid), saturation or undersaturated dicarboxylic acids are (for example Oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid and phthalic acid), hydroxy carboxylic acid (such as ascorbic acid, lactic acid, Fructus Mali pumilae Acid, tartaric acid and citric acid), or benzoic acid；Or organic sulfonic acid, such as unsubstituted or substituted (being for example optionally substituted by halogen) C₁-C₄Alkyl sulfonic acid or aryl sulfonic acid (such as methanesulfonic acid or p-methyl benzenesulfonic acid).Formula with least one acidic-group (I) chemical combination Thing or from chitin synthesis inhibitor class, ecdysone agonist class or other classifications reactive compound can for example with Alkali forming salt, such as slaine, such as alkali metal salt or alkali salt (such as sodium salt, potassium salt or magnesium salt)；Or with ammonia or organic Amine forming salt, the organic amine such as morpholine, piperidines, pyrrolidine, a rudimentary alkyl, dialkyl group or trialkylamine (such as ethamine, Diethylamine, triethylamine or dimethyl propyl amine), or rudimentary monohydroxy, dihydroxy or trihydroxy alkylamine (such as monoethanolamine, Diethanolamine or triethanolamine).Additionally, if appropriate, corresponding inner salt can also be formed.In the present invention, it is preferred to agriculture chemistry Upper favourable salt.In view of formula (I) compound or from chitin synthesis inhibitor class, ecdysone agonist class or other Substantial connection between the free form of the reactive compound of classification and its salt form, refers to free formula above and below every time (I) compound or the free activation from chitin synthesis inhibitor class, ecdysone agonist class or other classifications Compound or their salt should be understood as representing, and --- if being suitable for and be favourable --- which also includes corresponding salt respectively With free formula (I) compound or the trip from chitin synthesis inhibitor class, ecdysone agonist class or other classifications From reactive compound.This also in the corresponding way be applied to formula (I) compound and from chitin synthesis inhibitor class, cast off a skin The tautomer and its salt of the reactive compound of Hormone agonists class or other classifications.

In the present invention, term " active agent combinations " refers to formula (I) compound and presses down from chitin synthesis The various conjugates of the reactive compound of preparation class, ecdysone agonist class or other classifications, for example, mixed with single (ready-mix) form, with combination spraying mixture (such as tank mix being made up of the single preparation of each reactive compound (tank-mix)), or with the situation of its sequential application (such as within the appropriate short time such as a few houres or several days in succession Apply) under each reactive compound be used in combination.Close according to a kind of preferred embodiment, formula (I) compound and from chitin Into inhibitor class, ecdysone agonist class or other classifications reactive compound order of administration for the present invention practice and Speech is not critical.

When using the active agent combinations of the present invention as insecticide and acaricide, according to type is applied, apply Can be changed in relatively wide scope with rate.The rate of application of active agent combinations of the present invention is：When process plant parts (example Such as leaf) when：0.1 to 10,000g/ha, preferably 10 to 1,000g/ha, particularly preferred 50 to 300g/ha are (when by watering or dripping When note is applied, or even rate of application can be reduced, particularly when using inert base such as rock wool (rock wool) or perlite)；When When processing seed：2 to 200g is per 100kg seeds, the every 100kg seeds of preferably 3 to 150g, particularly preferred 2.5 to 25g are per 100kg Seed, extremely particularly preferred 2.5 to 12.5g are per 100kg seeds；When soil is processed：0.1 to 10,000g/ha, preferably 1 to 5000g/ha。

These rate of application are only referred to by way of example, rather than limit the present invention.

Protect the plants from a period of time that the active agent combinations of the present invention can be used for after treatment mentioned Animal pests invasion and attack.The time for providing protection generally continues 1 to 28 day after plant is processed with reactive compound, preferably 1 to 14 day, particularly preferred 1 to 10 day, it is extremely particularly preferred 1 to 7 day, or continue for up to 200 days after seed treatment.

The present invention active agent combinations, have concurrently good plant tolerance and favourable homoiothermic animal toxicity and Good environmental resistance, is suitable to protect plant and plant organ, improves harvesting yield, the quality for improving harvested material and preventing and treating Run in agricultural, gardening, animal husbandry, forestry, gardens and leisure facilities, the protection of storage product and material and health field Animal pests, particularly insecticide, arachnid, anthelmintic, nematicide and Mollusca.They are preferably used as crop protection Compositionss.They are to generally sensitive and resistant species and active to all or some stage of development.Above-mentioned insect includes：

Anoplura (Anoplura, Phthiraptera), such as Damalinia (Damalinia spp.), Haematopinus (Haematopinus spp.), Linognathus (Linognathus spp.), Pediculus (Pediculus spp.), Trichodectes (Trichodectes spp.)。

Arachnoidea (Arachnida), for example, Acarus siro (Acarus siro), Citrus aceria (Aceria Sheldoni), peronium Eriophyes (Aculops spp.), acupuncture Eriophyes (Aculus spp.), Amblyomma (Amblyomma Spp.), Argas (Argas spp.), Boophilus (Boophilus spp.), short whisker Acarapis (Brevipalpus spp.), Bryobia praetiosa (Bryobia praetiosa), Chorioptes (Chorioptes spp.), Dermanyssus gallinae (Dermanyssus Gallinae), wart demodicid mite (Epitrimerus pyri), true Tetranychus on Eotetranychus (Eotetranychus spp.), pears (Eutetranychus spp.), Eriophyes (Eriophyes spp.), half Tarsonemus (Hemitarsonemus spp.), Hyalomma (Hyalomma spp.), Isodesspp (Ixodes spp.), latrodectus mactans (Latrodectus mactans), Metatetranychus spp., Oligonychus (Oligonychus spp.), Ornithodoros (Ornithodoros spp.), Panonychus citri category (Panonychus spp.), Fructus Citri tangerinae rue rust mite (Phyllocoptruta oleivora), Polyphagotarsonemus latus Banks (Polyphagotarsonemus latus), Psoroptes (Psoroptes spp.), Rh (Rhipicephalus Spp.), root demodicid mite category (Rhizoglyphus spp.), Sarcoptesspp (Sarcoptes spp.), Middle East gold scorpion (Scorpio Maurus), Stenotarsonemus spp., Tarsonemus (Tarsonemus spp.), Tetranychus (Tetranychus spp.)、Vasates lycopersici。

Bivalve mollusks (Bivalva) guiding principle, for example, decorations shellfish category (Dreissena spp.).

Lip foot mesh (Chilopoda), for example, DIWUGONG category (Geophilus spp.), Scutigera spp..

Coleoptera (Coleoptera), for example, acanthoscelides obtectus (Acanthoscelides obtectus), beak rutelian category (Adoretus spp.), willow firefly chrysomelid (Agelastica alni), click beetle category (Agriotes spp.), Rhizoma Solani tuber osi gill angle Gold Testudiniss (Amphimallon solstitialis), furniture death watch beetle (Anobium punctatum), Genus Anoplophora Hope (Anoplophora spp.), flower are as belonging to (Anthonomus spp.), Anthrenus (Anthrenus spp.), Ah gill Gold Testudiniss The moth-eaten category (Attagenus spp.) of category (Apogonia spp.), Atomaria spp., fur, evil bar bean weevil (Bruchidius Obtectus), bean weevil category (Bruchus spp.), ceutorhynchus (Ceuthorhynchus spp.), Cleonus mendicus, The chest stuffiness relieving Agriotes spp (Conoderus spp.), root neck are as belonging to (Cosmopolites spp.), brown New Zealand's rib wing melolonthid (Costelytra zealandica), Curculio (Curculio spp.), the hidden beaks of Yang Gan are as (Cryptorhynchus Lapathi), khapra beetle category (Dermestes spp.), chrysomelid category (Diabrotica spp.), epilachna genus (Epilachna Spp.), Nicotiana tabacum L. drilling worm (Faustinus cubae), globose spider beetle (Gibbium psylloides), black different pawl sugarcane Gold Testudiniss (Heteronychus arator), Hylamorpha elegans, North America house longhorn beetle (Hylotrupes bajulus), purple lucerne Mu leaf is as (Hypera postica), Hypothenemus spp., the big brown hock gill Gold Testudiniss (Lachnosterna of Caulis Sacchari sinensis Consanguinea), colorado potato bug (Leptinotarsa decemlineata), rice root weevil (Lissorhoptrus Oryzophilus), cylinder beak is as belonging to (Lixus spp.), the moth-eaten category (Lyctus spp.) of powder, pollen beetle (Meligethes Aeneus), the west May melolonthid (Melolontha melolontha), Migdolus spp., black day Bos (Monochamus spp.), Naupactus xanthographus, golden spider beetle (Niptus hololeucus), coconut palm moth rhinoceros gold Testudiniss (Oryctes rhinoceros), saw-toothed grain beetle (Oryzaephilus surinamensis), black grape ear image (Otiorrhynchus sulcatus), little blue and white Gold Testudiniss (Oxycetonia jucunda), the chrysomelid (Phaedon of Radix Cochleariae officinalises ape Cochleariae), eat phyllobranchia Gold Testudiniss category (Phyllophaga spp.), Japan popillia flavosellata fairmaire (Popillia japonica), Weevil category (Premnotrypes spp.), Brassica campestris L golden head flea beetle (Psylliodes chrysocephala), Ptinus (Ptinus spp.), dark-coloured ladybug (Rhizobius ventralis), lesser grain borer (Rhizopertha dominica), grain weevil category (Sitophilus spp.), sharp Rhynchophorus (Sphenophorus spp.), stem as belong to (Sternechus spp.), Symphyletes spp., tenebrio molitor (Tenebrio molitor), Tribolium (Tribolium spp.), speckle khapra beetle category (Trogoderma spp.), seed belong to as category (Tychius spp.), Xylotrechus Chevrolat (Xylotrechus spp.), away from ground beetle (Zabrus spp.)。

Collembola (Collembola), for example, arms Onychiurus arcticus (Onychiurus armatus).

Dermaptera (Dermaptera), for example, European earwig (Forficula auricularia).

Times sufficient mesh (Diplopoda), for example, Blaniulus guttulatus.

Diptera (Diptera), for example, Aedess (Aedes spp.), Anopheless (Anopheles spp.), garden hair Mosquito (Bibio hortulanus), calliphora erythrocephala (Calliphora erythrocephala), Mediterranean Ceratitis spp (Ceratitis capitata), Carysomyia (Chrysomyia spp.), Callitroga (Cochliomyia spp.), people torsalo (Cordylobia anthropophaga), Culex (Culex spp.), Cuterebra (Cuterebra spp.), Fructus Canarii albi severe excess syndrome Fly (Dacus oleae), human botfly (Dermatobia hominis), Drosophila (Drosophila spp.), Fannia (Fannia spp.), Gasterophilus (Gastrophilus spp.), Hylemyia (Hylemyia spp.), Hyppobosca Spp., Hypoderma (Hypoderma spp.), Liriomyza (Liriomyza spp.), Lucilia (Lucilia spp.), family Fly category (Musca spp.), Bemisia spp (Nezara spp.), Oestrus (Oestrus spp.), Oscinella frit (Oscinella frit), Herba chenopodii spring fly (Pegomyia hyoscyami), Phorbia (Phorbia spp.), Genus Stomoxys (Stomoxys spp.), Gadfly (Tabanus spp.), Tannia spp., European daddy-longlegs (Tipula paludosa), dirty fly Category (Wohlfahrtia spp.).

Gastropoda (Gastropoda), for example, Arion spp., Biomphalaria (Biomphalaria spp.), vesicle spiral shell Category (Bulinus spp.), Agriolimax (Deroceras spp.), native snail category (Galba spp.), Lymnaea (Lymnaea Spp.), Katayama (Oncomelania spp.), amber spiro spp (Succinea spp.).

Anthelmintic guiding principle (Helminths), for example, Ancylostoma duodenale (Ancylostoma duodenale), Si Lilan Grab mouth nematode (Ancylostoma ceylanicum), ancylostoma braziliense (Acylostoma braziliensis), the mouth of hook Turbatrix (Ancylostoma spp.), seemingly draw ascarid nematicide (Ascaris lubricoides), Ascariss (Ascaris Spp.), Malaysia cloth Shandong nematicide (Brugia malayi), cloth Shandong, Timor nematicide (Brugia timori), Bunostomum (Bunostomum spp.), Chabertia category (Chabertia spp.), branch testis trematodiasiss category (Clonorchis spp.), Gu Cypress Turbatrix (Cooperia spp.), Dicrocoelium (Dicrocoelium spp.), dictyocaulus filaria (Dictyocaulus filaria), fish tapeworm (Diphyllobothrium latum), guinea worm (Dracunculus medinensis), Echinococcus granulosus (Echinococcus granulosus), Echinococcus multilocularis (Echinococcus multilocularis), pinworm (Enterobius vermicularis), Faciola Spp., blood Trichinella (Haemonchus spp.), Heterakis (Heterakis spp.), short and small nibble shell cestode (Hymenolepis nana), Metastrongylus apri category (Hyostrongulus spp.), loa loa (Loa Loa), thin neck Turbatrix (Nematodirus spp.), oesophagostomum (Oesophagostomum spp.), Opisthorchis (Opisthorchis spp.), Onchocerca caecutiens (Onchocerca volvulus), this off-line Eimeria (Ostertagia difficult to understand Spp.), Paragonimuss (Paragonimus spp.), Schistosomen spp., Fu Shi quasi-colubriformis (Strongyloides fuelleborni), strongyloides intestinalis (Strongyloides stercoralis), excrement Strongylus (Stronyloides spp.), taeniasis bovises (Taenia saginata), taeniasis suises (Taenia solium), rotation hair shape Nematicide (Trichinella spiralis), Trichinella nativa (Trichinella nativa), strain Trichinella britovi (Trichinella britovi), southern trichinella (Trichinella nelsoni), Trichinella Pseudopsiralis, trichostrongyluss (Trichostrongulus spp.), whipworm (Trichuris Trichuria), Wuchereria bancrofti (Wuchereria bancrofti).

Additionally, protozoacide can be also prevented and treated, such as eimeria (Eimeria).

Heteroptera (Heteroptera), for example, the beautiful stinkbug category of squash bug (Anasa tristis), plan (Antestiopsis spp.), native chinch bug category (Blissus spp.), pretty fleahopper category (Calocoris spp.), Campylomma livida, different back of the body chinch bug category (Cavelerius spp.), Cimex (Cimex spp.), Creontiades Dilutus, Fructus Piperiss coried (Dasynus piperis), the long rod lace bug (Diconocoris of Dichelops furcatus, Hou Shi Hewetti), red cotton bug category (Dysdercus spp.), America stinkbug category (Euschistus spp.), Eurygasterspp category (Eurygaster spp.), Heliopeltis spp., Horcias nobilellus, Leptocorisa spp category (Leptocorisa Spp.), leaf beak coried (Leptoglossus phyllopus), Lygus Hahn (Lygus spp.), the black chinch bug (Macropes of sugarcane Excavatus), Miridae (Miridae), Bemisia spp, Oebalus spp., Pentomidae, square butt stinkbug (Piesma Quadrata), wall stinkbug category (Piezodorus spp.), cotton puppet speckle lower limb fleahopper (Psallus seriatus), Pseudacysta Persea, Rhodnius (Rhodnius spp.), Sahlbergella singularis (Sahlbergella singularis), black stinkbug category (Scotinophora spp.), pear crown network pentatomidae (Stephanitis nashi), Tibraca spp., Triatoma (Triatoma spp.)。

Homoptera (Homoptera), for example, without net long tube Aphis (Acyrthosipon spp.), Aeneolamia Spp., Aphalaridae (Agonoscena spp.), Aleurodes spp., sugarcane Aleyrodes (Aleurolobus Barodensis), Aleurothrixus spp., Fructus Mangifera Indicae leafhopper category (Amrasca spp.), Anuraphis cardui, kidney circle Armored scale category (Aonidiella spp.), Soviet Union bloom aphid (Aphanostigma piri), Aphis (Aphis spp), grape leaf Cicadae (Arboridia apicalis), roundlet armored scale category (Aspidiella spp.), Aspidiotus category (Aspidiotus spp.), Atanus spp., eggplant ditch are without net aphid (Aulacorthum solani), Aleyrodes (Bemisia spp.), Lee short-tail aphid It is (Brachycaudus helichrysii), Brachycolus spp., brevicoryne brassicae (Brevicoryne brassicae), little Brown back rice plant hopper (Calligypona marginata), beautiful yellow head cicadellid (Carneocephala fulgida), cane powder angle aphid (Ceratovacuna lanigera), Cercopidae (Cercopidae), lecanium category (Ceroplastes spp.), Fructus Fragariae Ananssae nail aphid (Chaetosiphon fragaefolii), sugarcane Huang Xue's armored scale (Chionaspis tegalensis), tea green leafhopper (Chlorita onukii), walnut blackspot aphid (Chromaphis juglandicola), dark brown Aspidiotus (Chrysomphalus ficus), Semen Maydiss leafhopper (Cicadulina mbila), Coccomytilus halli, soft a red-spotted lizard category (Coccus spp.), the hidden tumor aphid of tea Fischer (Cryptomyzus ribis), Dalbulus spp., Dialeurodes spp., Diaphorina spp., white back of the body armored scale category (Diaspis spp.), Doralis spp., shoe giant coccid category (Drosicha Spp.), western rounded tail Aphis (Dysaphis spp.), grey mealybug category (Dysmicoccus spp.), Empoasca flavescens (Empoasca spp.), woolly aphid category (Eriosoma spp.), Erythroneura spp., Euscelis bilobatus, coffee Coffee ground mealybug (Geococcus coffeae), phony disease of peach poison leafhopper (Homalodisca coagulata), mealy plum aphid (Hyalopterus arundinis), icerya purchasi category (Icerya spp.), piece angle leafhopper category (Idiocerus spp.), flat beak Leafhopper category (Idioscopus spp.), small brown rice planthopper (Laodelphax striatellus), Lecanium spp., lepidosaphes shimer (Lepidosaphes spp.), radish aphid (Lipaphis erysimi), long tube Aphis (Macrosiphum spp.), Mahanarva fimbriolata, kaoliang aphid (Melanaphis sacchari), Metcalfiella spp., wheat are without net aphid (Metopolophium dirhodum), the flat wing speckle aphid of black edge (Monellia costalis), Monelliopsis Pecanis, tumor aphid genus (Myzus spp.), Caulis et Folium Lactucae sativae patch up Macrosiphus spp (Nasonovia ribisnigri), rice green leafhopper category (Nephotettix spp.), brown paddy plant hopper (Nilaparvata lugens), Oncometopia spp., Orthezia Praelonga, Fructus Myricae rubrae edge aleyrodid (Parabemisia myricae), Paratrioza spp., Parlatoria (Parlatoria Spp.), Pemphigus (Pemphigus spp.), com planthopper (Peregrinus maidis), Phenacoccus (Phenacoccus spp.), Yang Ping wing woolly aphids (Phloeomyzus passerinii), phorodon aphid (Phorodon Humuli), grape phylloxera category (Phylloxera spp.), the brown point of sago cycas armored scale (Pinnaspis aspidistrae), Buttockss stricture of vagina mealybug category (Planococcus spp.), pyriform original giant coccid (Protopulvinaria pyriformis), white mulberry scale (Pseudaulacaspis pentagona), mealybug category (Pseudococcus spp.), Psylla spp (Psylla spp.), gold Nikol (Pteromalus spp.), Pyrilla spp., large bamboo hat with a conical crown and broad brim Aspidiotus category (Quadraspidiotus spp.), Quesada Gigas, flat thorn mealybug category (Rastrococcus spp.), Rhopalosiphum (Rhopalosiphum spp.), black bourch category (Saissetia spp.), Scaphoides titanus, green bugs (Schizaphis graminum), sago cycas thorn targe A red-spotted lizard (Selenaspidus articulatus), long clypeus plant hopper category (Sogata spp.), white backed planthopper (Sogatella furcifera)、Sogatodes spp.、Stictocephala festina、Tenalaphara malayensis、 Tinocallis caryaefoliae, wide breast froghopper category (Tomaspis spp.), sound Aphis (Toxoptera spp.), greenhouse Aleyrodid (Trialeurodes vaporariorum), individual Psylla spp (Trioza spp.), jassids category (Typhlocyba Spp.), sharp armored scale category (Unaspis spp.), Fructus Vitis viniferae root nodule louse (Viteus vitifolii).

Hymenoptera (Hymenoptera), for example, Diprion (Diprion spp.), real tenthredinidae (Hoplocampa Spp.), hair ant category (Lasius spp.), MonomoriumMayr (Monomorium pharaonis) and Vespa (Vespa spp.).

Isopoda (Isopoda), for example, Armadillidium (Armadillidium vulgare), comb beach louse (Oniscus ) and ball Armadillidium (Porcellio scaber) asellus.

Isoptera (Isoptera), for example, Reticulitermes (Reticulitermes spp.), odontotermes (Odontotermes spp.)。

Lepidoptera (Lepidoptera), for example, Sang Jian Autographa spps (Acronicta major), tired noctuid (Aedia Leucomelas), Agrotis (Agrotis spp.), cotton leaf ripple noctuid (Alabama argillacea), dry evil spirit noctuid Category (Anticarsia spp.), Barathra brassicae, cotton lyonetid (Bucculatrix thurberiella), loose chi The yellow volume moth (Cacoecia podana) of earwig (Bupalus piniarius), Caulis et Folium Lini, Capua reticulana, codling moth (Carpocapsa pomonella), winter geometrid moth (Cheimatobia brumata), straw borer spp (Chilo spp.), fir color Volume moth (Choristoneura fumiferana), grape codling moth (Clysia ambiguella) (Clysia ambiguella), Cnaphalocerus Spp., earias insulana (Earias insulana), Anagasta kuehniella (Ephestia kuehniella), pornography and drug moth (Euproctis chrysorrhoea), cutworm category (Euxoa spp.), dirty cut Noctua (Feltia spp.), greater wax moth It is (Galleria mellonella), genus heliothis (Helicoverpa spp.), Heliothis (Heliothis spp.), brown Knit moth (Hofmannophila pseudospretella), Homonamagnanima (Homona magnanima), apple ermine moths (Hyponomeuta padella), Beet armyworm category (Laphygma spp.), stricture of vagina Lyonetiaspp (Leucoptera spp.), Herba Marsileae Quadrifoliae are thin The white grand cutworm of moth (Lithocolletis blancardella), green fruit winter noctuid (Lithophane antennata), bean (Loxagrotis albicosta), Euproctis (Lymantria spp.), malacosoma neustria (Malacosoma Neustria), lopper worm (Mamestra brassicae), rice hair shin noctuid (Mocis repanda), mythimna separata (Mythimna separata), Oria spp., Oulema oryzae (Oulema oryzae), small noctuid (Panolis Flammea), Pectinophora gossypiella (Pectinophora gossypiella), Fructus Citri tangerinae lyonetid (Phyllocnistis citrella), dish Pier (Pieris spp.), diamond-back moth (Plutella xylostella), spodoptera (Prodenia spp.), Pseudaletia spp., Semen sojae atricolor noctuid (Pseudoplusia includens), Pyrausta nubilalis (Hubern). (Pyrausta nubilalis), Rachiplusia spp., Spodoptera (Spodoptera spp.), Thermesia gemmatalis, bag rain moth (Tinea pellionella), Tineolabisselliella (Tineola bisselliella), the green volume moth of oak (Tortrix viridana), Trichoplusiaspp (Trichoplusia spp.), Tuta spp..

Orthoptera (Orthoptera), for example, family Xi (Acheta domesticus), oriental cockroach (Blatta Orientalis), blatta germanica (Blattella germanica), Gryllotalpa spp (Gryllotalpa spp.), leucophaea maderae (Leucophaea maderae), Locustamigratoria (Linnaeus) category (Locusta spp.), black locust category (Melanoplus spp.), periplaneta americana (Periplaneta americana), desert locust (Schistocerca gregaria).

Siphonaptera (Siphonaptera), for example, Ceratophylluses (Ceratophyllus spp.) and Xanthopsyllacheopis (Xenopsylla cheopis)。

Comprehensive mesh (Symphyla), for example, kahikatea worm (Scutigerella immaculata).

Thysanoptera (Thysanoptera), for example, rice thripses (Baliothrips biformis), Enneothrips Flavens, flower thripss category (Frankliniella spp.), net Thrips (Heliothrips spp.), greenhouse bar hedge thrips (Hercinothrips femoralis), card Thrips (Kakothrips spp.), Fructus Vitis viniferae thrips (Rhipiphorothrips Cruentatus), hard Thrips (Scirtothrips spp.), Taeniothrips cardamoni, Thrips (Thrips spp.)。

Thysanoptera (Thysanura), for example, lepismae saccharinae (Lepisma saccharina).

Plant nematode includes, for example, eel Turbatrix (Anguina spp.), Aphelenchoides (Aphelenchoides spp.), thorn Turbatrix (Belonoaimus spp.), Bursaphelenchus (Bursaphelenchus Spp.), fuller's teasel Ditylenchus dipsaci (Ditylenchus dipsaci), ball Heterodera (Globodera spp.), helicotylenchus Category (Heliocotylenchus spp.), Heterodera (Heterodera spp.), minute hand Turbatrix (Longidorus Spp.), Meloidogyne (Meloidogyne spp.), Pratylenchus (Pratylenchus spp.), Radopholus similis Throne (Radopholus similis), shallow bid spin line Eimeria (Rotylenchus spp.), burr Turbatrix (Trichodorus Spp.), Tylenchorhynchus (Tylenchorhynchus spp.), pulvinulus sword Turbatrix (Tylenchulus spp.), half puncture Nematicide (Tylenchulus semipenetrans) and Xiphinema (Xiphinema spp.).

If appropriate, active agent combinations of the invention can also finite concentration or rate of application be used as herbicide, peace Full agent, growth regulator, or as improving the medicament of plant characteristic, or be used as microbicide, such as it is antifungal, anti- Mycete agent, bactericide, antiviral (including the medicament of opposing viroid) are used as opposing MLO (mycoplasma-like organism(MLO)) and RLO (classes Rickettsia) medicament.

Reactive compound can be converted into conventional formulation, such as solution, Emulsion, wettable powder, water base and Oil-based Suspension Agent, powder, powder agent, unguentum, soluble powder, soluble granule, spread fertilizer over the fields granule, outstanding breast concentrating agents, Jing active ingredients The native compound of thing dipping, the synthetic of Jing reactive compounds dipping, the microcapsule in fertilizer, and polymeric material.

These preparations are made in a known way, such as by reactive compound is mixed with filler (extender), i.e. Mix with liquid flux and/or solid carrier；Optionally employ surfactant (i.e. emulsifying agent and/or dispersant) and/or foaming Agent.These preparations can be prepared in suitable device, also can be prepared before administration or in application.

Be suitable as auxiliary agent is adapted for imparting compositionss itself and/or preparation therefrom (such as spray liquid, seed dressing Agent) with the material of particular characteristics (such as some technical characteristics and/or specific biological characteristicses).Conven-tional adjuvants include：Filling Agent, solvent and carrier.

Suitable filler is for for example：Water；Polarity and nonpolar organic chemistry liquid, such as arene and non-aromatic hydrocarbon (if appropriate, which can also be substituted, be etherified and/or ester for class (such as paraffin, alkylbenzene, alkylnaphthalene, chlorobenzene), alcohol and polyhydric alcohol Change), ketone (such as acetone, Ketohexamethylene), ester (include fat and oil) and (gathering) ether, unsubstituted and substituted amine, amide, Lactams (such as N- alkyl pyrrolidones) and lactone, sulfone and sulfoxide (such as dimethyl sulfoxide).

If filler used is water, such as organic solvent is it is also possible to use as cosolvent.Suitable liquid flux is main For：Aromatic compound, such as dimethylbenzene, toluene or alkylnaphthalene；Chlorinated aromaticss and chlorinated aliphatic hydrocarbons, such as chlorobenzene, vinyl chloride Or dichloromethane；Aliphatic hydrocarbon, such as hexamethylene or paraffin, such as petroleum distillate, mineral oil and vegetable oil；Alcohol, such as butanol or second Glycol, and their ether and ester；Ketone, such as acetone, methyl ethyl ketone, methyl iso-butyl ketone (MIBK) or Ketohexamethylene；Intensive polar solvent is such as Dimethyl sulfoxide；And water.

According to the present invention, carrier is naturally occurring or synthetic, organic or inorganic material, and which can be solid or liquid, and Reactive compound can be mixed or be combined to obtain the preferably property applied, and is particularly applied to plant or plant parts or kind Son.Solid or liquid-carrier are usually inert and should be suitable in agricultural.

Suitable solid or liquid-carrier have：

For example, ammonium salt；With natural rock dust, such as Kaolin, clay, Talcum, Chalk, quartz, attapulgite, montmorillonite or silicon Diatomaceous earth；And synthesis rock dust, such as finely divided silicon dioxide, aluminium oxide and silicate；Can be used for the solid carrier bag of granule Include：The natural rock for example crushed and be classified, such as calcite, marble, Pumex, meerschaum and dolomite, and synthesis it is inorganic With organic powder particles, and the granule of Organic substance (such as paper, sawdust, coconut husk, corncob and tobacco stem)；Available emulsifying agent And/or foaming agent includes：Such as nonionic and anion emulsifier, such as polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether (such as alkylaryl polyglycol ether), alkylsulfonate, alkyl sulfate, arylsulphonate and protein hydrolysate；It is adapted to Dispersant be nonionic and/or ionic species, such as the material of following classification：Alcohol-POE- and/or-POP ethers, acid and/or POP POE esters, alkylaryl and/or POP POE ethers, fat and/or POP POE adducts, POE- and/or POP- polyhydric alcohol spread out Biological, POE- and/or POP- anhydrosorbitols alcohol adducts or-sugared adduct, alkyl or aryl sulfate, alkyl or aryl sulphur Hydrochlorate, and alkyl or aryl phosphate or corresponding PO- ethers adduct.Additionally, suitable oligomer or polymer are, example Such as by vinyl-type monomer (vinylic monomer), by acrylic acid, by EO and/or PO individually or with such as (polynary) alcohol Or (many) amine combines those being derived.It is also possible to use lignin and its sulfonic acid, it is non-modified and modified Cellulose, aromatics and/or aliphatic sulfonic acid and their adducts with formaldehyde.

Sticker (tackifier) can be used in preparation, for example：Carboxymethyl cellulose；And powder, granule or latex shape The natural and synthetic polymer of formula, such as Radix Acaciae senegalis, polyvinyl alcohol and polyvinyl acetate；Or natural phospholipid, such as cephalin And lecithin, and synthetic phospholipid.

Coloring agent can be used, for example：Inorganic pigment, such as ferrum oxide, titanium oxide and Prussian blue；And toner, Such as alizarin coloring agent, azo colouring agent and metal phthalocyanine coloring agent；And micronutrient, such as iron salt, manganese salt, boron salt, mantoquita, Cobalt salt, molybdenum salt and zinc salt.

Other available additives have spice, optionally modified mineral oil or vegetable oil, wax and nutrient (to include micro Nutrient), such as iron salt, manganese salt, boron salt, mantoquita, cobalt salt, molybdenum salt and zinc salt.

Also there may be stabilizer, such as low temperature stabilizer, preservative, antioxidant, light stabilizer or other improvementization And/or the reagent of physical stability.

By obtained in commercially available preparation, the active compound content of type of service can change in relative broad range.Using shape The activity compound concentration of formula is in the range of 0.00000001 to 97 weight % reactive compound, preferably 0.0000001 to 97 In the range of weight %, particularly preferably in the range of 0.000001 to 83 weight % or 0.000001 to 5 weight %, it is extremely particularly preferred In the range of 0.0001 to 1 weight %.

The active agent combinations of the present invention can be with its commercially available preparation and by the preparation and other activations The type of service that compound mixes and prepares is present, and described other reactive compounds such as insecticide, attractant, disinfectant, kills Bacteriocin, acaricide, nematicide, antifungal, growth regulatory substance, herbicide, safener, fertilizer or chemical information thing Matter.

Also can mix with other known reactive compound, the other known reactive compound such as herbicide, fertilizer, life Long regulator, safener, semiochemicalses；Or mix with the reagent for improving plant characteristic.

When as insecticide, the active agent combinations of the present invention can be with its commercially available preparation and by described The type of service that preparation is mixed with synergist and prepared is present.Synergist is the chemical combination for improving reactive compound effect and adding Thing, the synergist for being added itself need not be active.

When as insecticide, the active agent combinations of the present invention can be with its commercially available preparation and by described Preparation and inhibitor mixed and the type of service for preparing is present, the inhibitor reduces reactive compound after use in plant ring Degraded on border, plant parts surface or in plant tissue.

These compounds are suitable for the usual manner of type of service and use.

All plants and plant parts can be according to present invention process.Plant is understood to mean that all of plant herein And plant population, such as need and unwanted wild plant or crop plants (including naturally occurring crop plants).Make Thing plant can for example be can be by conventional breeding and optimal seeking method or by biotechnology and gene engineering research or by this The combination of a little methods and the plant that obtains, including transgenic plant and including can by or kind property right (varietal can not be received Property rights) plant variety protected.Plant parts be understood to mean that all of ground of plant and underground position and Organ, such as bud, leaf, Hua Hegen, the example that can be mentioned that be leaf, needle, stem, dry, flower, sporophore, fruit and seed and root, Tuber and rhizome.Plant parts also include harvested material and asexual and case of propagation material, such as fruit, seed, cutting, block Stem, rhizome, sprout, seed, bulbil (bulbil), cuttage bar and running roots.

According to the process that the present invention is carried out to plant and plant parts with active agent combinations, by conventional treatment side Method directly carry out or by the compound effects around which, environment or storage space and carry out, the conventional treatment method Such as dipping, spraying, evaporation, atomizing, broadcast sowing, smear, injecting, and for propagating materialss, especially for seed, can also apply Use one or more layers coating.

Following plant can be referred to as the plant that can be processed according to the present invention：Cotton Gossypii, Caulis et Folium Lini, vine, fruit, Vegetable, such as Rosa kind (Rosaceae sp.) (such as pomaceous fruits such as Fructus Mali pumilae and pears, and kernel approaches such as Fructus Pruni, Fructus Pruni pseudocerasi, almond And Fructus Persicae, and berries such as Fructus Fragariae Ananssae), Ribesioidae sp., Juglandaceae category kind of (a Juglandaceae sp.), Betulaceae category kind (Betulaceae sp.), Anacardiaceae category kind (Anacardiaceae sp.), Fagaceae category kind (Fagaceae sp.), Moraceae Category kind (Moraceae sp.), Oleaceae category kind (Oleaceae sp.), Actinidiaceae category kind (Actinidaceae sp.), Camphor tree Section's category kind (Lauraceae sp.), Musaceae category kind (Musaceae sp.) (such as Banana tree and banana plantation), Rubiaceae Category kind (Rubiaceae sp.) (such as coffee), Theaceae category kind (Theaceae sp.), Sterculiaceae category kind (Sterculiceae Sp.), Rutaceae category kind (Rutaceae sp.) (such as Fructus Citri Limoniae, orange and grapefruit)；Solanaceae category kind (Solanaceae sp.) (such as Fructus Lycopersici esculenti), Liliaceae category kind (Liliaceae sp.), Compositae category kind (Asteraceae sp.) (such as Caulis et Folium Lactucae sativae), umbrella shape Section's category kind (Umbelliferae sp.), Cruciferae category kind (Cruciferae sp.), Chenopodiaceae category kind (Chenopodiaceae Sp.), Cucurbitaceae category kind (Cucurbitaceae sp.) (such as Fructus Cucumidis sativi), Herba Alii fistulosi section category kind (Alliaceae sp.) (such as fragrant-flowered garlic Herba Alii fistulosi, Bulbus Allii Cepae), Papilionaceae category kind of (Papilionaceae sp.) (a such as Semen Pisi sativi)；Major crop plants such as grass family genus kind (Gramineae sp.) (such as Semen Maydiss, lawn (turf), frumentum such as Semen Tritici aestivi, rye (Secale cereale L.), rice, Fructus Hordei Vulgaris, Herba bromi japonici, broomcorn millet and black Semen Tritici aestivi), Compositae category kind (Asteraceae sp.) (such as Helianthi), Cruciferae category kind (Brassicaceae sp.) (such as Archon Caulis et Folium Brassicae capitatae, red cabbage, broccoli, Brassica oleracea L. var. botrytis L., brussels sprout, Plantula Brassicae chinensis (pak choi), slash indigo plant, Radix Raphani and Brassica campestris L, mustard Dish, Radix Cochleariae officinalises (horseradish) and Herba Oenanthes Javanicae), pulse family category kind of (Fabacae sp.) (a such as Kidney bean, Semen arachidis hypogaeae), Papilionaceae category kind (such as Semen sojae atricolor), Solanaceae category kind of (a such as Rhizoma Solani tuber osi), Chenopodiaceae category kind (such as sugar beet, fodder beet, Swiss chard, edible Radix Betae)；Useful plants and ornamental plant in gardens and forest；And the respective Jing genetic modifications type of these plants.

The active agent combinations of the present invention are particularly suitable for the process of seed.Here can be specifically mentioned above as excellent Choosing or the conjugate of the present invention for particularly preferably referring to.For example, by insect cause to crop plants great majority infringement early in After when being invaded and harassed during seed storage and be introduced into seed in soil, and shortly go out during plant germination and after germination It is existing.This stage is particular importance, because the especially sensitive or even small infringement of the root and bud of plant is likely in growth The death of whole plant can be caused.Therefore by using suitable compositionss protection seed and germination plant be especially have it is great Meaning.

By processing plant seed pest control known some time, and it is the theme updated.However, planting The process of son is with the series of problems that always cannot be solved in a satisfactory manner.Therefore, it is desirable to develop such being used for Protection seed and the method for the plant for germinateing, which applies crop protection without the need for extra after sowing or after plant germination Product.Additionally, also wanting to optimize the amount of reactive compound used in such a way：The plant germinateed for seed and carries For optimal protection against insect invasion and attack, but reactive compound used will not damage plant itself.Especially, process seed Method it should also be taken into account that the intrinsic insecticidal properties of transgenic plant with using minimal amount of crop protection products obtain to seed The best protection of the plant for germinateing.

Correspondingly, the present invention relates particularly to process seed to protect by using the active agent combinations of the present invention The method of seed and the plant that germinateing from pest attacks.For protecting seed and the plant for germinateing to invade from insect The inventive method attacked includes such a method, wherein by seed with the reactive compound of formula (I) and from chitin synthesis One kind in the reactive compound 1 to 22 listed one by one above of inhibitor class, ecdysone agonist class or other classifications is same Shi Jinhang process.Which also includes such a method, wherein by seed with the reactive compound of formula (I) and from chitin synthesis One kind in the reactive compound 1 to 22 listed one by one above of inhibitor class, ecdysone agonist class or other classifications exists Different time is processed.The invention further relates to the active agent combinations of the present invention be used for process seed with protect seed and Purposes of the plant of generation from pest attacks.Moreover, it relates to Jing active agent combinations of the present invention process with Make to protected from the seed of pest infestation.The invention further relates to the reactive compound of meridional (I) and from chitin synthesis press down One kind in the reactive compound 1 to 22 listed one by one above of preparation class, ecdysone agonist class or other classifications while The seed of process.The invention further relates to the reactive compound of meridional (I) and from chitin synthesis inhibitor class, ecdyson swash A kind of seed in different time process in the reactive compound 1 to 22 listed one by one above of dynamic agent class or other classifications. In the reactive compound of meridional (I) and from the upper of chitin synthesis inhibitor class, ecdysone agonist class or other classifications It is a kind of in the case of the seed of different time process in the reactive compound 1 to 22 that text is listed one by one, the present composition Each reactive compound may be present in the different layers on seed.Reactive compound containing formula (I) and from chitin synthesis It is a kind of in the reactive compound 1 to 22 listed one by one above of inhibitor class, ecdysone agonist class or other classifications Layer is optionally separated by intermediate layer.The invention further relates to such seed, wherein by the reactive compound of formula (I) and from The reactive compound 1 to 22 listed one by one above of chitin synthesis inhibitor class, ecdysone agonist class or other classifications In a kind of component as coating or apply as other a layer in addition to coating or in addition multilamellar.

One of advantage of the present invention is, due to the specific absorbability characteristic of active agent combinations of the present invention, to use these Compositions-treated seed not only protects the plant that seed itself is generated after also protecting germination from pest attacks.In like fashion, may be used Save at seeding time or its direct process subsequently soon to crop.

Another advantage is that, compared with single insecticidal active compound, the collaboration of active agent combinations of the present invention Strengthen insecticidal activity, expection activity when which is administered alone more than two kinds of reactive compounds.It is further advantageous that sterilizing with single Reactive compound is compared, and the collaboration of active agent combinations of the present invention strengthens bactericidal activity, and it is independent which exceedes reactive compound Expection activity during administration.This can optimize the consumption of reactive compound.

It is also regarded as advantageously, the active agent combinations of the present invention can also be used in particular for transgenic seed, by The plant grown up to by this kind of seed can express the albumen of targeting insect.At active agent combinations by using the present invention Manage this kind of seed, some insects can be prevented and treated for example, by the expression of insecticidal proteins, and also can be protected in addition and From the infringement of active agent combinations of the present invention.

The active agent combinations of the present invention are suitable to protect already mentioned above for agricultural, greenhouse, forest or gardening In any plant variety seed.Particularly, take the form of the seed of following plant：Semen Maydiss, Semen arachidis hypogaeae, canola (canola), Brassica campestris L, Semen Papaveriies, Semen sojae atricolor, Cotton Gossypii, Radix Betae (such as sugar beet and fodder beet), rice, broomcorn millet, Semen Tritici aestivi, Fructus Hordei Vulgaris, swallow Wheat, rye (Secale cereale L.), Helianthi, Nicotiana tabacum L., Rhizoma Solani tuber osi or vegetable (such as Fructus Lycopersici esculenti, Caulis et Folium Brassicae capitatae species).The active agent combinations of the present invention It is equally applicable for processing the seed of fruit plant already mentioned above and vegetable.Particularly importantly process corn and soybean, Cotton Gossypii, The seed of Semen Tritici aestivi and canola or Brassica campestris L.

As mentioned above, it is also particular importance to process transgenic seed with the active agent combinations of the present invention.Institute It is the plant seed for usually containing at least one heterologous gene to state seed, and the heterologous gene control is more with specific insecticidal properties The expression of peptide.Heterologous gene in transgenic seed may originate from microorganism, such as bacillus cereuss (Bacillus), root nodule bacteria (Rhizobium), pseudomonass (Pseudomonas), Serratieae (Serratia), Trichoderma spp. (Trichoderma), stick-like bar Bacterium (Clavibacter), sacculus mycete (Glomus) or viscous broom mould (Gliocladium).Instant invention is especially suited for process containing At least one is derived from bacillus and its gene outcome shows opposing European corn borer (European corn borer) And/or the transgenic seed of the heterologous gene of Diabrotica virgifera (Western corn rootworm) activity.Particularly preferably From the heterologous gene of Bacillus thuringiensis (Bacillus thuringiensis).

In the context of the present invention, by the active agent combinations of the present invention individually or in the form of appropriate formulation It is applied to seed.It is preferred that, seed is processed in the state of damaging during one kind is stable enough to avoid processing.Generally, plant Sub any time point that can be between harvesting and sowing is processed.The seed being usually used is separated with plant, and is removed Remove cob, shell, stem, epidermis, hair or sarcocarp.

When processing seed, it is often necessary to note, in such a way to being applied to the reactive compound of the present invention of seed The amount of the amount of conjugate and/or other additives is selected, so that the germination of seed is not adversely affected or not The plant that damage grows up to.Especially for the reactive compound may under certain rate of application with phytotoxic effects, this Any must account for.

The compositionss of the present invention directly can be applied, i.e., without any other component and undiluted.Typically it will be preferred to will combination Thing is applied to seed in the form of appropriate formulation.Be suitable to process seed dosage form and method be it is well known by persons skilled in the art, And be described in such as documents below：US 4,272,417 A、US 4,245,432 A、US 4,808,430 A、US 5,876, 739 A、US 2003/0176428 A1、WO 2002/080675 A1、WO 2002/028186 A2。

Reactive compound that can be used according to the invention can be converted into conventional Seed dressing formulations, for example solution, Emulsion, outstanding Floating agent, powder, foam, slurry agent or other coated compositions for seed, and ULV preparations.

These preparations are in known manner by mixing to prepare the reactive compound with the additive of routine, described to add Plus agent such as conventional fillers and solvent or diluent, coloring agent, wetting agent, dispersant, emulsifying agent, defoamer, preservative, Secondary thickening agent, binding agent, gibberellins and water.

May be present in can be used according to the invention Seed dressing formulations in coloring agent be that all routines for this purpose Toner.Herein, the pigment for being slightly soluble in water can be not only used, it is also possible to use water-soluble dyestuff.If example includes entitled red The dyestuff of bright B, C.I. pigment red 112 and C.I. solvent reds 1.

May be present in can be used according to the invention Seed dressing formulations in Suitable humectants to promote moistening to be conventionally used for All substances in the preparation of agricultural chemical activity compound.Preferably use alkyl naphthalene sulfonic acid ester, such as LOMAR PWA EINECS 246-676-2 diisopropyl ester Or LOMAR PWA EINECS 246-676-2 diisobutyl ester.

May be present in can be used according to the invention Seed dressing formulations in suitable dispersant and/or emulsifying agent to be conventionally used for All nonionics, anion and cation dispersing agent in the preparation of agricultural chemical activity compound.Preferably use nonionic or The mixture of anionic dispersing agents or nonionic or anionic dispersing agents.The suitable non-ionic dispersing agent that can be mentioned that is special It is ethylene oxide/propylene oxide block polymer, alkyl phenol polyglycol ether and triphenylethylene phenol polyglycol ether and its phosphoric acid Change or sulfated derivative.Suitable anionic dispersing agents particularly lignosulfonates, polyacrylate and aromatic yl sulphonate/ Formaldehyde condensation products.

May be present in can be used according to the invention Seed dressing formulations in defoamer to be conventionally used for agricultural chemical activity The material of all suppression foams in the preparation of compound.Organic silicon defoamer and magnesium stearate are used preferably.

May be present in can be used according to the invention Seed dressing formulations in preservative to be used for agriculture chemistry for this purpose All substances in compositionss.Dichlorophen (dichlorophene) and benzyl alcohol hemiformal are referred to by way of example can.

May be present in can be used according to the invention Seed dressing formulations in secondary thickening agent for agriculture can be used for for this purpose All substances in industry Chemical composition that.Preferred cellulose derivant, acrylic acid derivative, xanthan gum, modified clay and subdivision Scattered silicon dioxide.

May be present in can be used according to the invention Seed dressing formulations in binding agent be can be used to dressing seed product it is all often Rule binding agent.As preferably can be mentioned that polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose.

May be present in can be used according to the invention Seed dressing formulations in gibberellins preferred gibberellins A1, A3 (=it is red mould Acid), A4 and A7, particularly preferably using gibberellin.Gibberellins are known (referring to R.Wegler " Chemie der Pflanzenschutz-und ”[Chemistry of Crop Protectant Composition and Pesticides], volume 2, Springer Verlag, 1970,401-412 page).

Seed dressing formulations that can be used according to the invention directly or after water in advance dilution can be used to process the kind of wide scope Son, including including the seed of transgenic plant.Herein, extra cooperative effect can also be with the material association by expressing formation Occur together.

Can be conventionally used for dress seed operation all blenders be suitable for can be used according to the invention Seed dressing formulations or by The Seed dressing formulations process seed by adding water and obtained preparation.Especially, walked during seed dressing operation as follows Suddenly：Wherein seed is placed in blender, concrete the desired amount of Seed dressing formulations itself is added or before after dilute with water The Seed dressing formulations, all substances are mixed until said preparation is uniformly distributed on seed.If appropriate, place is dried afterwards Reason.

The processing method of the present invention can be used for the organism (GMO) for processing genetic modification, such as plant or seed.Heredity is repaiied Decorations plant (or transgenic plant) are the plant that wherein heterologous gene has stably been integrated into genome.Statement " heterologous gene " The gene for providing outside plant or assembling mainly is provided, and when core, chloroplast or mitochondrial genome is introduced into Can by express valuable protein or polypeptide or by downward or silence be present in endophytic (one or more) its Its gene (such as using antisense technology, co-suppression technology or RNAi technology [RNA interference]) and give conversion plant with new or The agronomy of improvement or other characteristics.Heterologous gene in genome is also known as transgenic.By which in Plant Genome Particular location and the transgenic that defines, referred to as transformation plant (event) or transgenic line.

According to plant species or plant variety, its plantation place and growth conditionss (soil, weather, vegetative growth phase, nutrition (diet)), process of the invention can also produce super plus and (" collaboration ") effect.For example, can use to exceed actual desired below Effect：Reduce the rate of application of the reactive compound and compositionss that can be used according to the present invention and/or widen its activity profile and/or carry High its activity, improve plant growing, improve high temperature or cold tolerance, raising are to arid or to the resistance to of water or soil salt content By property, Flowering quality is improved, harvesting simpler, hasting of maturity is made, is improved harvesting yield, increase fruit, improve plant height, make leaf color Greener, more prematurity, improve harvested products quality and/or improve its nutritive value, improve fruit in sugared concentration, improve adopt Receive the bin stability and/or its processing characteristics of product.

Under some rate of application, active agent combinations of the present invention can also have plant to strengthen effect.Therefore, they fit Together in adjusting vegeto-animal defense system to resist the invasion and attack of undesired plant pathogen and/or microorganism and/or virus.If Properly, one of the reason for this is probably conjugate (such as funguses) increased activity of the present invention.Herein, plant reinforcing (induction of resistance) material is understood to mean that those materials or substance combinations, and which can stimulate the defense system of plant, so that It is proper be subsequently inoculated with undesired plant pathogen and/or microorganism and/or virus when, Jing process plant show to these Undesired plant pathogen and/or microorganism and/or virus significantly resistance.In the present invention, undesired plant Pathogenic bacterium and/or microorganism and/or virus are understood to mean that phytopathogenic funguses, antibacterial and virus.Therefore, it is of the invention Material can be used to protect the invasion and attack in plant a period of time after treatment from above-mentioned pathogen.Bring the time of protection usual Continue 1 to 10 day, preferably 1 to 7 day after plant being processed with the reactive compound.

It is preferred that the plant processed according to the present invention and plant variety include that these plants are particularly advantageous useful with imparting All plants (whether being obtained by breeding and/or animal nutrition) of the hereditary material of feature.

The plant and plant variety for further preferably being processed according to the present invention has resistance to one or more biotic factor, I.e. described plants against animal and microbial pests (for example to nematicide, insecticide, acarid, phytopathogenic fungi, antibacterial, virus and/ Or viroid) with preferably resisting power.

The plant and plant variety that can be also processed according to the present invention is that one or more abiotic stress factor is had to resist Those plants of property.Abiotic stress conditions may include, for example, arid, low temperature expose to the open air, heat exposure, osmotic stress, waterlogging, carry High soil salt content, the mineral for improving expose to the open air, ozone exposes to the open air, high light exposes to the open air, limited nitrogen nutrition element availability, limited phosphorus Nutrient availability keeps away shade.

The plant and plant variety that can be also processed according to the present invention is those plants being characterized with the yield characteristic for improving. The raising of the plant yield can be produced by for example following factor：The plant physiology of improvement, g and D, for example, imitated with water Rate, water retaining efficiency, improve nitrogen utilize, improve carbon assimilation, improvement photosynthesis, improve germination efficiency and plus It is rapid-result ripe.The shadow of the plant architecture (plant architecture) (under stress and non-stress condition) that yield can also be improved Ring, the plant architecture includes：Bloom ahead of time, to hybrid seed production control of blooming, rice shoot vigor, plant size, internode The kind of the quantity, each pod or fringe of number and interval, root growth, seed size, fruit size, pod size, pod quantity or fringe Quantum count, seed quality, the seed plumpness for improving, the seed dispersal for reducing, the pod cracking for reducing and lodging resistance.Other products Rate characteristic include seed composition (such as composition of carbohydrate content, protein content, oil content and oil), nutritive value, The reduction of anti-nutrient compounds, the machinability for improveing and more preferable storage stability.

Can be to have given expression to hybrid vigor (heterosis or hybrid vigour) according to the plant that the present invention is processed The hybrid plant of characteristic, the hybrid vigor characteristic generally causes that yield is higher, vigor is higher, it is more healthy and to biological and Abiotic stress factor has more preferable resistance.This kind of plant typically by make selfing male sterility parent line (female parent) with it is another One selfing male can educate parent line (male parent) hybridization and made by.Hybrid seed generally harvesting is from male sterile plants, and sells To grower.Male sterile plants sometimes (such as in Semen Maydiss) can by emasculation (i.e. mechanical removal Male reproductive organ or Male flower) and prepare, but more frequently, male sterility is produced by the genetic determinant in Plant Genome 's.In this case, especially when seed is whne the required product harvested from hybrid plant, it is often advantageous that guaranteeing comprising negative Male fertility in the hybrid plant of the genetic determinant of duty male sterility recovers completely.This can be by assuring that male parent tool There is appropriate restoring gene to realize, the gene can recover the miscellaneous of the genetic determinant containing responsible male sterility Plant the male fertility of plant.The genetic determinant of responsible male sterility is can be located in Cytoplasm.Cytoplasmic male sterility The example of property (CMS) is for example described in (WO 1992/005251, WO 1995/ in Btassica kind (Brassica species) 009910th, WO 1998/27806, WO 2005/002324, WO 2006/021972 and US be 6,229,072).However, being responsible for hero The genetic determinant of property sterility is may be alternatively located in Matrix attachment region.Male sterile plants can also pass through Plant Biotechnology method Such as genetic engineering and obtain.A kind of useful especially mode for obtaining male sterile plants is described in WO 89/10396, its In, for example, ribonuclease (such as barnase) is optionally expressed in the tapetal cell of stamen.Then can educate Property can recover (example by expression of the ribonuclease inhibitor (such as barstar) in tapetal cell Such as WO 1991/002069).

The plant that can be processed according to the present invention or plant variety (are obtained by Plant Biotechnology method such as genetic engineering ) for herbicide tolerant plants, i.e., the plant of the herbicide tolerant for one or more being given.This kind of plant can be by heredity Conversion is obtained by selecting the plant containing the mutation for giving this herbicide tolerant.

Herbicide tolerant plants have such as glyphosate (glyphosate) tolerant plants, i.e., to herbicide glyphosate or The plant of its salt tolerance.For example, glyphosate-tolerant plant can be by using coding 5- enol pyruvylshikimate -3- phosphate synthases (EPSPS) gene-transformed plant and obtain.The example of this EPSPS genes is Salmonella typhimurium (Salmonella Typhimurium) the AroA genes (mutant CT7) (Comai et al., Science (1983), 221,370-371) of antibacterial, soil CP4 genes (Barry et al., the Curr.Topics Plant of earth Bacillus category kind (Agrobacterium sp.) antibacterial (1992), Physiol. 7,139-145), coding petunia (petunia) EPSPS gene (Shah et al., Science (1986), 233,478-481), the gene of coding for tomato EPSPS (Gasser et al., J.Biol.Chem. (1988), 263, 4280-4289) or coding yard grass belong to (Eleusine) EPSPS gene (WO 2001/66704).Which is alternatively mutated EPSPS, as described in such as EP-A 0837944, WO 2000/066746, WO 2000/066747 or WO 2002/026995. Glyphosate-tolerant plant also can encode the gene of glyphosate oxidoreductase by expression and obtain, such as US 5,776,760 Hes Described in US 5,463,175.Glyphosate-tolerant plant also can encode the gene of glyphosate acetyl transferase by expression and obtain , as described in such as WO 2002/036782, WO 2003/092360, WO 2005/012515 and WO 2007/024782. Glyphosate-tolerant plant also can be obtained by selecting the plant of the mutation containing naturally occurring said gene, such as such as WO Described in 2001/024615 or WO 2003/013226.

There is to herbicide the plant of resistance to be for other, such as to suppressing the herbicide of glutamine synthase --- such as double third Ammonia phosphine (bialaphos), careless fourth phosphine (phosphinothricin) or glufosinate-ammonium (glufosinate) --- with toleration Plant.This kind of plant can make the enzyme of herbicide removing toxic substances by expression or resist the glutamine synthase mutant of inhibitory action and obtain .The effective detoxication enzyme of such a is the enzyme for for example encoding careless fourth phosphinothricin acetyl transferring enzyme (such as from streptomyces category kind Bar the or pat protein of (Streptomyces species)).The plant of expression external source grass fourth phosphinothricin acetyl transferring enzyme describes In, such as US 5,561,236, US 5,648,477, US 5,646,024, US 5,273,894, US 5,637,489, US 5, 276,268th, US 5,739,082, US 5,908,810 and US 7,112,665.

Other herbicide tolerant plants also have the herbicide tolerant to suppressing hydroxyphenyl pyravate dioxygenase (HPPD) Plant.Hydroxyphenyl pyravate dioxygenase is the enzyme for being catalyzed the reaction that p-hydroxybenzene pyruvic acid (HPP) (HPP) changes into 2,5-dihydroxy-.alpha.-toluic acid.. According to WO 1996/038567, WO 1999/024585 and WO 1999/024586, the plant of HPPD inhibitor tolerance can use The gene for encoding naturally occurring resistance HPPD enzyme or the gene for encoding mutated HPPD enzymes are converted.HPPD is suppressed Even if the toleration of agent can also pass through, and with coding, some natural HPPD enzymes are suppressed but to remain to form 2,5-dihydroxy-.alpha.-toluic acid. by HPPD inhibitor The gene pairss plant of enzyme converted and obtained.This kind of plant and gene are in WO 1999/034008 and WO 2002/36787 In be described.Plant, can be also compiled by using to the toleration of HPPD inhibitor in addition to the gene with coding HPPD toleration enzymes The gene pairss plant of code prephenate dehydrogenase is converted and is improved, as described in WO 2004/024928.

Other herbicide resistant plants are the plant for having toleration to acetolactate synthase (ALS) inhibitor.It is known ALS inhibitor includes such as sulfonylureas, imidazolone, triazolo pyrimidine, 2-pyrimidinyl oxy (sulfenyl) benzoate and/or sulfonyl Aminocarbonyl triazolinone herbicide.The different mutation of known ALS enzymes (also referred to as acetohydroxy acid synthase, AHAS) are imparted for not With herbicide and the tolerations of different group herbicides, such as such as Tranel and Wright, Weed Science (2002), 50, Described in 700-712 and US 5,605,011, US 5,378,824, US 5,141,870 and US 5,013,659.Sulfonylureas The production of tolerant plants and imidazolinone-tolerant plant has been described in US 5,605,011, US 5,013,659, US 5, 141,870、US 5,767,361、US 5,731,180、US 5,304,732、US 4,761,373、US 5,331,107、US 5,928,937 and US 5,378,824；And international publication text WO 1996/033270.Other imidazolinone-tolerants are planted Thing is also described in, such as WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373rd, WO 2006/015376, WO 2006/024351 and WO 2006/060634.Other sulfonylureas and imidazoline Ketone tolerant plants are also described in such as WO 2007/024782.

Can be by mutation, by right in the presence of herbicide to other plants of imidazolone and/or sulfonylureas tolerance The selection of cell culture is obtained by mutagenic breeding, such as such as US 5, to Semen sojae atricolor, WO 1997/41218 in 084,082 In in rice, US 5,773,702 and WO 1999/057965 in Radix Betae, US 5,198,599 to Caulis et Folium Lactucae sativae or WO 2001/ Description in 065922 to Helianthi.

The plant processed also dependent on the present invention or plant variety (are obtained by Plant Biotechnology method such as genetic engineering ) for insect resistant transgenic plant, i.e., to some targeted insects plants of the invasion and attack with resistance.This kind of plant can be by heredity Conversion is obtained, or is obtained by selecting the plant containing the mutation for giving this insect-resistant.

Herein, term " insect resistant transgenic plant " includes any plant containing at least one transgenic, institute State coded sequence of the transgenic comprising the following material of coding：

1) from the insecticidal crystal protein matter or its insecticidal part of Bacillus thuringiensis, such as Crickmore et al. exists Microbiology and Molecular Biology Reviews (1998), it is being collected in 62,807-813, by (the online http updated in thuringiensis bacillus toxin name by Crickmore et al. (2005):// Www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/) insecticidal crystal protein, or its insecticidal part, example Such as the protein or its insecticidal part of Cry protein-based Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Ae or Cry3Bb；Or Person

2) with parasite killing in the presence of other crystalline proteins of second from Bacillus thuringiensis or one part The thuringiensis bacillus crystallin or one part of activity, the binary toxin being for example made up of Cy34 and Cy35 crystalline proteins (Moellenbeck et al., Nat.Biotechnol. (2001), 19,668-72；Schnepf et al., Applied Environm.Microb.(2006),71,1765-1774)；Or

3) the hybrid insecticidal proteins of the part containing two kinds of different insecticidal crystal proteins from Bacillus thuringiensis, as described above 1) hybrid of albumen or the hybrid of above-mentioned albumen 2), the Cry1A.105 albumen for for example being produced by Semen Maydiss strain MON98034 (WO 2007/027777)；Or

4) above-mentioned 1) -3) in point any one albumen, some of them, particularly 1-10 aminoacid are by another aminoacid Substitute, so as to obtain the model of the target insect species acted on by the insecticidal activity higher to target insect species, and/or extension Enclose, and/or due to causing the change of coding DNA, such as Semen Maydiss strain MON863 or MON88017 in clone or conversion process In Cry3Bb1 albumen or the Cry3A albumen in Semen Maydiss strain MIR604；Or

5) from Bacillus thuringiensis or Bacillus cercuses (Bacillus cereus) parasite killing secreted protein or its kill Worm part, such as listed trophism insecticidal proteins (VIP) in following network address：http:// Www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, such as egg of VIP3Aa protides In vain；Or

6) have in the presence of second secreted protein from Bacillus thuringiensis or Bacillus cercuses and kill The Bacillus thuringiensis of worm activity or the secreted protein of Bacillus cercuses, the binary being for example made up of VIP1A and VIP2A albumen Toxin (WO 1994/21795)；Or

7) the hybrid parasite killing egg of the part containing the different secreted proteins from Bacillus thuringiensis or Bacillus cercuses In vain, for example it is above-mentioned 1) in albumen hybrid or it is above-mentioned 2) in albumen hybrid；Or

8) it is above-mentioned 1) into 3) putting any one albumen, some of them, particularly 1-10 aminoacid are by another amino Acid is substituted, so as to obtain the model of the target insect species acted on by the insecticidal activity higher to target insect species, and/or extension Enclose, and/or due to causing the change (its still encoding insecticidal proteins) of coding DNA, such as Cotton Gossypii strain in clone or conversion process It is the VIP3Aa albumen in COT102.

Certainly, insect resistant transgenic plant used herein is also included containing above-mentioned 1 to the 8 apoplexy due to endogenous wind any one of coding Any plant of the combination of the gene of albumen.In one embodiment, insect-resistant plants contain on more than one coding The transgenic of the albumen of any one of 1 to 8 class is stated, to extend the scope of acted on target insect species or postpone insecticide pair The generation of plant resistance to environment stress, by using there is to same target species of insect insecticidal activity but there are different model of action (for example Be bound to the different receptor binding sites of insecticide) different albumen.

The plant processed also dependent on the present invention or plant variety (are obtained by Plant Biotechnology method such as genetic engineering ) there is toleration to abiotic stress factor.This kind of plant can pass through genetic transformation or by selecting comprising this side of body of imparting The plant of the mutation of urgent resistance and obtain.Useful especially stress tolerant plants include following plant：

A. comprising can reduce poly- (ADP- ribose) polymerase (PARP) gene in plant cell or plant expression and/or The plant of the transgenic of activity, as described in WO 2000/004173 or EP 04077984.5 or EP 06009836.5.

B. the enhancing stress comprising the expression and/or activity that can reduce PARG encoding genes in plant or plant cell is resistance to By the plant of the transgenic of property, as described in such as WO 2004/090140；

The enhancing side of body of the Plant functional enzyme c. containing encoding nicotinamide adenine-dinucleotide salvage biosynthetic pathways The plant of the transgenic of urgent toleration, the enzyme include nicotinamidase, nicotinate phosphoribosyltransferase, NAMN Adenine transferring enzyme, nicotinamide adenine dinucleotide synzyme or nicotinamide phosphoribosyl transferase, are such as described in for example In EP 04077624.7 or WO 2006/133827 or PCT/EP07/002433.

The plant processed also dependent on the present invention or plant variety (are obtained by Plant Biotechnology method such as genetic engineering ) show to harvest the quantity of product, the change of quality and/or bin stability and/or harvest special component in product The change of property, for example：

1) transgenic plant of synthesis modification starch, the physiochemical characteristics of the modified starch --- particularly straight chain forms sediment Powder content or amylose/amylopectin ratio, degree of branching, average chain length, side chain distribution, viscosity characteristicses, gel resistance, starch Granularity and/or morphology of starch grain --- change is there occurs compared with the synthetic starch in agriotype plant cell or plant, So that the modified starch is better adapted for some applications.The transgenic plant of these synthesis modification starch is described in such as EP 0571427、WO 1995/004826、EP 0719338、WO 1996/15248、WO 1996/19581、WO 1996/27674、 WO 1997/11188、WO 1997/26362、WO 1997/32985、WO 1997/42328、WO 1997/44472、WO 1997/45545、WO 1998/27212、WO 1998/40503、WO 99/58688、WO 1999/58690、WO 1999/ 58654、WO 2000/008184、WO 2000/008185、WO 2000/28052、WO 2000/77229、WO 2001/ 12782、WO 2001/12826、WO 2002/101059、WO 2003/071860、WO 2004/056999、WO 2005/ 030942、WO 2005/030941、WO 2005/095632、WO 2005/095617、WO 2005/095619、WO 2005/ 095618、WO 2005/123927、WO 2006/018319、WO 2006/103107、WO 2006/108702、WO 2007/ 009823、WO 2000/22140、WO 2006/063862、WO 2006/072603、WO 2002/034923、EP 06090134.5、EP 06090228.5、EP 06090227.7、EP 07090007.1、EP 07090009.7、WO 2001/ 14569、WO 2002/79410、WO 2003/33540、WO 2004/078983、WO 2001/19975、WO 1995/26407、 WO 1996/34968、WO 1998/20145、WO 1999/12950、WO 1999/66050、WO 1999/53072、US 6, 734,341、WO 2000/11192、WO 1998/22604、WO 1998/32326、WO 2001/98509、WO 2001/ 98509、WO 2005/002359、US 5,824,790、US 6,013,861、WO 1994/004693、WO 1994/009144、 In WO 1994/11520, WO 1995/35026 and WO 1997/20936.

2) synthesize non-starch carbohydrate polymer or synthesis has compared with not genetically modified agriotype plant There is the transgenic plant of the non-starch carbohydrate polymer of the property of change.Example is generation polyfructosan --- especially Inulin-type and fructan-type polyfructosan --- plant, such as EP 0663956, WO 1996/001904, WO 1996/ 021023rd, described in WO 1998/039460 and WO 1999/024593；Produce the plant of α-Isosorbide-5-Nitrae glucosan, such as WO 1995/ 031553、US 2002/031826、US 6,284,479、US 5,712,107、WO 1997/047806、WO 1997/ 047807th, described in WO 1997/047808 and WO 2000/14249；Generation α -1, the plant of 6 branched α-Isosorbide-5-Nitrae glucosan, such as Described in WO 2000/73422；And the plant of generation alternan, such as WO 2000/047727, EP 06077301.7, US Described in 5,908,975 and EP 0728213.

3) transgenic plant of hyaluronan, such as such as WO 2006/032538, WO 2007/039314, WO are produced 2007/039315th, described in WO 2007/039316, JP 2006/304779 and WO 2005/012529.

The plant that can be also processed according to the present invention or plant variety (are obtained by Plant Biotechnology method such as genetic engineering ) plant that changes for fiber properties, such as vegetable lamb.This kind of plant can pass through genetic transformation or by selecting containing tax Give the plant of the mutation of the fiber properties of this change and obtain, this kind of plant includes：

A) plant comprising the Cellulose-synthase gene for changing form, such as in vegetable lamb, such as WO 1998/000549 It is described；

B) plant comprising rsw2 the or rsw3 homologous nucleic acids for changing form, such as such as vegetable lamb, WO 2004/ Described in 053219；

The plant of the expression c) with the sucrose phosphosynthase for improving, such as in vegetable lamb, such as WO 2001/017333 It is described；

The plant of the expression d) with the sucrose synthase for improving, such as vegetable lamb, as described in WO 02/45485；

E) wherein (such as by the downward of fiber selectivity beta-1,3-glucanase) connects in the intercellular of fibrocyte base portion The plant that the opportunity of silk gate changes, such as vegetable lamb, as described in WO 2005/017157；

F) fiber with the reactivity for changing (for example by N-acetyl glucosamine transferase gene (include nodC) with And the expression of chitin synthetase gene) plant, such as vegetable lamb, as described in WO 2006/136351.

The plant or plant variety that can be also processed according to the present invention (is obtained by Plant Biotechnology method such as genetic engineering ) it is the plant with oil cloth (profile) characteristic for changing, the Btassica (Brassica) of such as Brassica campestris L or correlation is planted Thing.This kind of plant can be obtained by genetic transformation or by selecting the plant of the mutation containing the oily characteristic for giving this change , this kind of plant includes：

A) plant of oil of the generation with high oleic acid content, such as rapeseed plant, such as such as US 5,969,169, US 5, Described in 840,946 or US 6,323,392 or US 6,063,947；

B) produce the plant of the oil with low linolenic, such as rapeseed plant, such as US 6,270,828, US 6, Described in 169,190 or US 5,965,755；

C) plant of oil of the generation with low-level satisfied fatty acid, such as rapeseed plant, such as such as US 5,434, Described in 283.

The useful especially transgenic plant that can be processed according to the present invention is to encode one or more comprising one or more The plant of the gene of toxin, and be with the available transgenic plant of following trade name：YIELD(such as Semen Maydiss, Cotton Gossypii, Semen sojae atricolor),(such as Semen Maydiss),(such as Semen Maydiss),(for example Semen Maydiss),(such as Semen Maydiss),(Cotton Gossypii),(Cotton Gossypii), Nucotn(Cotton Gossypii),(such as Semen Maydiss),With(Rhizoma Solani tuber osi).Can The example of the herbicide tolerant plants for referring to is with the available corn variety of following trade name, cotton variety and soybean varieties： Roundup(to glyphosate tolerance, such as Semen Maydiss, Cotton Gossypii, Semen sojae atricolor), LibertyIt is (resistance to careless fourth phosphine Receive, for example Brassica campestris L),(to imidazolone tolerate) and(sulfonylureas being tolerated, such as Semen Maydiss).Can be mentioned that Herbicide resistant plants (with the plant that conventional herbicide tolerant mode is cultivated) include with titleCity The kind (such as Semen Maydiss) sold.

The useful especially transgenic plant that can be processed according to the present invention is the combination comprising transformation plant or transformation plant Plant, which is listed in the data base of for example multiple country administrative organizations (see such as http:// Gmoinfo.jrc.it/gmp_browse.aspx and http://www.agbios.com/dbase.php).

Listed plant can be processed in a particularly advantageous manner with the active agent combinations of the present invention.Above-mentioned active ingredient The preferred scope of combination is also applied for the process of these plants.Especially emphasize using the activation for specifically referring to herein Compound conjugate processes plant.

The active agent combinations of the present invention are not only active to plant insect, sanitary insect pest and storage Product Pests, And to for example hard Tickss of the parazoon (vermin and endoparasite) in veterinary applications, soft ticks, acaricide, trombiculid, Fly (bite and suck), parasitic fly larvae, louse, hair louse, poultry louse and flea are also worked.The parasite includes：

Anoplura (Anoplurida), such as Haematopinus, Linognathus, Pediculus, Phtirus spp. and pipe Pediculus (Solenopotes spp.)。

Mallophaga (Mallophagida) and Amblycera (suborder Amblycerina) and thin angle suborder It is (suborder Ischnocerina), such as filoplume Pediculus (Trimenopon spp.), Menopon (Menopon spp.), huge Trichodectes (Trinoton spp.), Bovicola (Bovicola spp.), Werneckiella spp., Lepikentron Spp., Damalinia (Damalina spp.), Trichodectes and Felicola (Felicola spp.).

Diptera and Nematocera (suborder Nematocerina) and Brachycera (suborder Brachycerina), such as Aedess, Anopheless, Culex, Simulium (Simulium spp.), Eusimulium (Eusimulium Spp.), owl midge (Phlebotomus spp.), Lutzomyia (Lutzomyia spp.), Bitting midge (Culicoides Spp.), Chrysops (Chrysops spp.), tumor Gadfly (Hybomitra spp.), Atylotus (Atylotus spp.), horsefly Category, Chrysozona (Haematopota spp.), Philipomyia spp., honeybee Hippobosca (Braula spp.), Musca, tooth Stock fly category (Hydrotaea spp.), Genus Stomoxys, not Haematobia (Haematobia spp.), fly category (Morellia Spp.), Fannia, Glossina (Glossina spp.), Calliphora (Calliphora spp.), Lucilia, Carysomyia, dirty fly Category, Sarcophaga (Sarcophaga spp.), Oestrus, Hypoderma, Gasterophilus (Gasterophilus spp.), Hippobosca (Hippobosca spp.), Lipoptena (Lipoptena spp.) and Melophagus (Melophagus spp.).

Siphonaptera (Siphonapterida), such as flea category (Pulex spp.), Ctenocephalus (Ctenocephalides Spp.), Xenosyllaspp (Xenopsylla spp.) and Ceratophylluses.

Heteroptera (Heteropterida), such as Cimex, Triatoma, Rhodnius and Triatoma (Panstrongylus spp.)。

Blattaria (Blattarida), such as oriental cockroach, periplaneta americana, blatta germanica and Supella (Supella spp.)。

Acarian (Acari, Acarina) subclass and rear valve mesh (Metastigmate) and Mesostigmata (Mesostigmata), such as Argas, Ornithodoros (Ornithodorus spp.), residual beak Tickss category (Otobius Spp.), Isodesspp, Amblyomma, Boophilus, Dermacentor (Dermacentor spp.), Haemophysalis spp., glass eye Tickss Sharp demodicid mite category (Raillietia spp.) of category, Rh, Dermanyssus (Dermanyssus spp.), thorn, Pneumonyssus (Pneumonyssus spp.), breast thorn demodicid mite category (Sternostoma spp.) and Vespacarus (Varroa spp.).

Axle Acarina (Actinedida) (front valve suborder (Prostigmata)) and flour mite mesh (Acaridida) are (without valve Suborder (Astigmata)), such as honeybee shield demodicid mite category (Acarapis spp.), Cheyletiella (Cheyletiella spp.), fowl chela Demodicid mite category (Ornithocheyletia spp.), Myobia (Myobia spp.), Psorergates (Psorergates spp.), compacted shape Demodicid mite category (Demodex spp.), Trombidium (Trombicula spp.), Listrophorus spp., Tyroglyphus (Acarus Spp.), demodicid mite category under Tyrophaguses (Tyrophagus spp.), Caloglyphus (Caloglyphus spp.), neck (Hypodectes spp.), wing demodicid mite category (Pterolichus spp.), Psoroptes, Chorioptes, ear Sarcoptesspp (Otodectes Spp.), Sarcoptesspp, Notoedres (Notoedres spp.), lump demodicid mite category (Knemidocoptes spp.), Cytodites (Cytodites spp.) and Laminosioptes (Laminosioptes spp.).

The active agent combinations of the present invention are further adapted for the arthropod for preventing and treating the following animal of invasion and attack：Agricultural domestic animal, Such as cattle, sheep, goat, horse, pig, donkey, camel, Babalus bubalis L., rabbit, family chicken, turkey, duck, goose, Apiss；Other domestic animals, example Such as Canis familiaris L., cat, cage bird, pet fish；And so-called experimental animal, such as hamster, Cavia porcelluss, rat and mice.Prevent and treat these segmental appendages Animal is intended to the situation for reducing dead and (meat, milk, hair, skin, egg, honey etc.) yield reduction, so as to be lived by using the present invention Property combinations of compounds makes herding more economical and easier.

The active agent combinations of the present invention are used in veterinary applications and animal husbandry in a known way by following form: By enteral administration, such as by tablet, capsule, potus, Haust, granule, unguentum, pill, feed (feed- Through) form of method and suppository is carried out；By parenteral, such as by injecting (intramuscular, subcutaneous, intravenouss, peritoneum It is interior etc.), implant carries out；By nasal administration；By percutaneous drug delivery, such as to soak or take a shower, spray, sprinkle pour with drop, Cleaning and the form of dusting, and by means of moldings such as neck ring, ear tag, tail tag, limbs ligature containing reactive compound (limb band), halter, marker etc. are carried out.

When for domestic animal, poultry, domestic animal etc., the active agent combinations can be used as containing 1 to 80 weight % The preparation (such as powder, Emulsion, flowable) of the reactive compound of amount is directly used or is used after diluting 100 to 10000 times, or Person they can be used with chemical immersion agent (chemical dip).

Moreover, it has been discovered that the active agent combinations of the present invention show strong parasite killing to the insecticide for destroying industrial materials Effect.

It is preferred that but nonrestrictive example includes following insecticide：

Beetle, such as North America house longhorn beetle, Chlorophorus pilosis, furniture death watch beetle, the dead death watch beetle (Xestobium of report Rufovillosum), Ptilinus pectinicornis (Ptilinus pecticornis), Dendrobium pertinex, loose death watch beetle (Ernobius mollis), Priobium carpini, Lyctus brunneus Stephens (Lyctus brunneus), African powder moth (Lyctus Africanus), southern powder moth (Lyctus planicollis), quercitron moth (Lyctus linearis), pubescence powder are moth-eaten (Lyctus pubescens), Trogoxylon aequale, minthea rugicollis (Minthes rugicollis), material bark beetle kind (Xyleborus spec.), Tryptodendron spec., the black long moth (Apate monachus) of coffee, Mongolian oak length are moth-eaten (Bostrychus capucins), brown different wing length moth (Heterobostrychus brunneus), the moth-eaten kind of spine length (Sinoxylon spec.), dinoderus minutus (Dinoderus minutus)；

Dermaptera insecticide (Dermapterans), such as big wood wasp (Sirex juvencus), the big wood wasp (Urocerus of fir Gigas), Urocerus gigas toiganus (Urocerus gigas taignus), Urocerus augur；

Coptotermes formosanus Shtrari., such as European kalotermitid (Kalotermes flavicollis), numb head heap sand Coptotermes formosanus Shtrari. (Cryptotermes Brevis), the different Coptotermes formosanus Shtrari. (Heterotermes indicola) of ash point, American-European reticulitermes flavipe (Reticulitermes Flavipes), Sang Te reticulitermes flavipes (Reticulitermes santonensis), southern Europe reticulate pattern Coptotermes formosanus Shtrari. (Reticulitermes Lucifugus), Mastotermes darwiniensis (Mastotermes darwiniensis), Nevada Gu Coptotermes formosanus Shtrari. (Zootermopsis Nevadensis), Coptotermes formosanus Shtrari． (Coptotermes formosanus)；

Moth (Bristletail), such as lepismae saccharinae (Lepisma saccarina).

In the present invention, industrial materials are understood to mean that abiotic material, such as preferred plastics, binding agent, sizing material, paper Open and card, leather, timber, processed timber-work and coating composition.

Also optionally contain other insecticides with compositionss, and also optionally sterilize containing one or more Agent.

With regard to available mixing addO-on therapy, above-mentioned insecticide and antibacterial are can be found in.

Moreover, active agent combinations of the invention can be used to protect the thing contacted with salt water or brackish water Body --- particularly hull, sieve, net, building, mooring arrangement and signaling system --- is in case produce dirt.

Additionally, the active combination of the present invention individually or with other reactive compounds can be incorporated as antifouling composition.

The active agent combinations are further adapted for preventing and treating the animal pests in family, health and storage product protection, Insecticide, arachnid and the mite class for particularly running in closing space；The closing space for example residence, factory floor, Office, compartment etc..They individually or with other reactive compounds and auxiliary agent can be combined produces for domestic insecticide Preventing and treating these insects in product.They are all effective for sensitive and resistant species and whole stages of development.These nuisances include：

Scorpionida (Scorpionidea), for example, Mediterranean Huang scorpion (Buthus occitanus).

Acarina (Acarina), for example, adobe tick (Argas persicus), argas reflexus (Argas Reflexus), tongue demodicid mite subspecies (Bryobia ssp.), Dermanyssus gallinae, the thermophilic sweet demodicid mite (Glyciphagus domesticus) of family, non- Continent turicata (Ornithodorus moubat), brown dog tick (Rhipicephalus sanguineus), eutrombicula alfreddugesi (Trombicula alfreddugesi), Neutrombicula autumnalis, special thermophilic skin demodicid mite (Dermatophagoides Pteronissimus), the thermophilic skin demodicid mite of method (Dermatophagoides forinae).

Araneida (Araneae), for example, catching bird spider (Aviculariidae), circle spider (Araneidae).

Opiliones (Opiliones), for example, chelifer (Pseudoscorpiones chelifer), The blind spider of the Chang Shin of Pseudoscorpiones cheiridium, (Opiliones phalangium).

Isopoda, for example, comb beach louse, ball Armadillidium.

Times sufficient mesh, for example, Blaniulus guttulatus, mountain cricket worm (Polydesmus spp.).

Lip foot mesh, for example, DIWUGONG category.

Lepismae saccharinae mesh (Zygentoma), for example, comb lepismae saccharinae category (Ctenolepisma spp.), lepismae saccharinae, robber fireworm (Lepismodes inquilinus)。

Blattaria (Blattaria), for example, oriental cockroach, blatta germanica, Asia Lian (Blattella asahinai), horse Moral draws cockroach, angle abdomen Lian category (Panchlora spp.), wood Lian category (Parcoblatta spp.), Australian cockroach (Periplaneta australasiae), periplaneta americana, big brown big Lian (Periplaneta brunnea), smoke Perilpaneta americana (Periplaneta fuliginosa), brown belt cockroach (Supella longipalpa).

Jump mesh (Saltatoria), for example, family Xi.

Dermaptera, for example, European earwig.

Isoptera, for example, kalotermitid category (Kalotermes spp.), Reticulitermes.

Corrodentia (Psocoptera), for example, Lepinatus spp., powder corrodent category (Liposcelis spp.).

Coleoptera, for example, Anthrenus, fur moth category, khapra beetle category, long head ostomatid (Latheticus oryzae), hidden instep Cuckoo Eimeria (Necrobia spp.), Ptinus, lesser grain borer, grain weevil (Sitophilus granarius), rice weevil (Sitophilus oryzae), sitophilus zea-maises (Sitophilus zeamais), Stegobium paniceum (Stegobium paniceum).

Diptera, for example, Aedes aegypti (Aedes aegypti), Aedes albopictus (Aedes albopictus), band beak she Mosquito (Aedes taeniorhynchus), Anopheless, calliphora erythrocephala, great number fiber crops horsefly (Chrysozona pluvialis), multicolored vaginal discharge Culex pipiens pallens (Culex quinquefasciatus), northern house (Culex pipiens), ring beak culex (Culex Tarsalis), Drosophila, Fannia canicularis (Fannia canicularis), housefly (Musca domestica), owl midge, flesh fly (Sarcophaga carnaria), Simulium, tatukira (Stomoxys calcitrans), European daddy-longlegs.

Lepidoptera, for example, lesser wax-moth (Achroia grisella), greater wax moth, Indian meal moth (Plodia Interpunctella), stopper rain moth (Tinea cloacella), bag rain moth, Tineolabisselliella.

Siphonaptera, for example, ctenocephalides canis (Ctenocephalides canis), ctenocephalides felis (Ctenocephalides Felis), Pulex irritans (Pulex irritans), chigo (Tunga penetrans), Xanthopsyllacheopis.

Hymenoptera, for example, blazons hunchbacked ant (Camponotus herculeanus), black smelly ant (Lasius Fuliginosus), black ant (Lasius niger), Lasius umbratus, MonomoriumMayr, Paravespula spp., causeway Ant (Tetramorium caespitum).

Anoplura, for example, head louse (Pediculus humanus capitis), body louse (Pediculus humanus Corporis), wart cotten aphid category (Pemphigus spp.), Phylloera vastatrix, pubic louse (Phthirus pubis).

Heteroptera, for example, cimex hemipterus (Cimex hemipterus), bed bugs (Cimex lectularius), length It is red to hunt stinkbug (Rhodinus prolixus), invade and harass triatomid (Triatoma infestans).

In domestic field of pesticides, they can be individually or the reactive compound suitable with other is used in combination described Other suitable reactive compounds such as phosphoric acid ester, carbamatess, anabasine, pyrethroid, growth regulator Or other known insecticide reactive compound.

They be used for aerosol, without pressure spray product, such as pump spraying and atomizer spray (atomizer spray), from Dynamic atomizing system, propellant, foam, gel；For evaporating with the evaporating plate by made by cellulose or plastics, liquid Agent, the vaporizer product of gel and film evaporator, the vaporizer of impeller driven, in unpowered or passive vapo(u)rization system；For Moth paper is caught, moth bag is caught and is caught in moth glue；It is used in the bait shed as granule or powder agent or Poison bait station (bait Station in).

Active agent combinations of the present invention well kill insecticide and acaricidal action from following examples.Although single The effect that reactive compound shows is weaker, but conjugate show effect more than more than effect it is simple plus and.

During effect summation when the effect of active agent combinations is administered alone more than reactive compound, it is constantly present Insecticide and acaricidal cooperative effect.

The predictive role of the conjugate of two kinds of given reactive compounds can be according to S.R.Colby, Weeds15, (1967), 20-22 is calculated as below：

If

X be when reactive compound A withmThe rate of application of g/ha ormWhen the concentration of ppm is used, with undressed control The killing rate that the % of group is represented,

Y be when reactive compound B withnThe rate of application of g/ha ornWhen the concentration of ppm is used, with undressed control The killing rate that the % of group is represented,

E be when reactive compound A and B withmWithnThe rate of application of g/ha ormWithnWhen the concentration of ppm is used, with unprocessed Matched group the killing rates that represent of %,

Then

If kill insecticide or the mite killing killing rate of reality exceed value of calculation, the killing rate of the conjugate have it is super plus and Property, that is, there is cooperative effect.In this case, the killing rate for actually observing inherently exceedes the expection calculated using above formula Killing rate (E) value.

Embodiment

Embodiment A

Black peach aphid is tested

Solvent：78 pbw acetones

1.5 weight portion dimethylformamides

Emulsifying agent：0.5 weight portion alkylaryl polyglycol ether

To prepare the active agent preparations being adapted to, by solvent and the emulsifying of the reactive compound of 1 weight portion and the amount Agent mixes, and dope is diluted to desired concn with the water containing emulsifying agent.

By the blade institute of the Caulis et Folium Brassicae capitatae (Brassica oleracea) by black peach aphid (Myzus persicae) severe infestation Need the active agent preparations spraying treatment of concentration.

After required time, killing rate is determined, in terms of %.100% represents that all aphids are killed；0% indicates without aphid Worm is killed.The killing rate for determining is substituted into into Colby ' s formula (seeing above).

In this test, for example, the following active agent combinations of the application and the reactive compound phase being administered alone Than showing to cooperate with enhanced activity：

Table A -1：Black peach aphid is tested

* the activity that found=is surveyed

The activity that * calc.=are calculated using Colby formula

Table A -2：Black peach aphid is tested

* the activity that found=is surveyed

The activity that * calc.=are calculated using Colby formula

Embodiment B

The chrysomelid larva test of Radix Cochleariae officinalises ape

Solvent：78 pbw acetones

1.5 weight portion dimethylformamides

Emulsifying agent：0.5 weight portion alkylaryl polyglycol ether

To prepare the active agent preparations being adapted to, by solvent and the emulsifying of the reactive compound of 1 weight portion and the amount Agent mixes, and the dope is diluted to desired concn with the water containing emulsifying agent.

By the active agent preparation spraying treatment of the blade desired concn of Caulis et Folium Brassicae capitatae (Brassica oleracea) and in leaf The larva of Radix Cochleariae officinalises ape chrysomelid (Phaedon cochleariae) is inoculated with when piece is still moist.

After required time, killing rate is determined, in terms of %.100% represents that all beetle larvas are killed；0% table Show.The killing rate for determining is substituted into into Colby formula (seeing above).

In this test, the following active agent combinations of the application are showed compared with the reactive compound being administered alone Go out and cooperate with enhanced activity：

Table B-1：The chrysomelid larva test of Radix Cochleariae officinalises ape

* the activity that found=is surveyed

The activity that * calc.=are calculated using Colby formula

Table B-2：The chrysomelid larva test of Radix Cochleariae officinalises ape

* the activity that found=is surveyed

The activity that * calc.=are calculated using Colby formula

Embodiment C

Spodopterafrugiperda larva is tested

Solvent：78 pbw acetones

1.5 weight portion dimethylformamides

Emulsifying agent：0.5 weight portion alkylaryl polyglycol ether

By the active agent preparations spraying treatment of the blade desired concn of Caulis et Folium Brassicae capitatae (Brassica oleracea) and The larva of Spodopterafrugiperda (Spodoptera frugiperda) is inoculated with when blade is still moist.

After required time, killing rate is determined, in terms of %.100% represents that all larvas are killed；0% indicates without children Worm is killed.The killing rate for determining is substituted into into Colby ' s formula (seeing above).

Table C-1：Spodopterafrugiperda is tested

* the activity that found=is surveyed

The activity that * calc.=are calculated using Colby formula

Table C-2：Spodopterafrugiperda is tested

* the activity that found=is surveyed

The activity that * calc.=are calculated using Colby formula

Embodiment D

Tetranychus urticae tests (OP- resistances/spraying treatment)

Solvent：78 pbw acetones

1.5 weight portion dimethylformamides

Emulsifying agent：0.5 weight portion alkylaryl polyglycol ether

Kidney bean (the Phaseolus that will be invaded and harassed by the Tetranychus urticae (Tetranychus urticae) in all stages Vulgaris roundleaf piece) is sprayed with the active agent preparations of desired concn.

After required time, drug effect is determined, in terms of %.100% represents that all Tetranychus urticaes are killed；0% indicate without Tetranychus urticae is killed.

Table D-1：Tetranychus urticae is tested

* the activity that found=is surveyed

The activity that * calc.=are calculated using Colby formula

Claims

1. active agent combinations, which includes a kind of formula (I) compound

Wherein formula (I) compound is selected from one kind of the compound of formula (I-4), (I-5) and (I-6),

With

Methoxyfenozide

Wherein described formula (I) compound is 10 with the weight ratio of methoxyfenozide:1 to 1:10.

2. active agent combinations defined in claim 1 be used for prevent and treat agricultural, gardening, forestry, gardens and leisure facilities, The purposes of the animal pests run in the protection of storage product and material.

3. the animal run in the protection for prevent and treat agricultural, gardening, forestry, gardens and leisure facilities, storage product and material is used for The method of nuisance, it is characterised in that the active agent combinations defined in claim 1 are acted on into animal pests And/or its habitat and/or seed.

4. the method for claim 3, it is characterised in that the reactive compound and methoxyfenozide of formula (I) are acted on into kind simultaneously Son.

5. the method for claim 3, it is characterised in that the reactive compound and methoxyfenozide of formula (I) are acted in different time In seed.

6. the active agent combinations of claim 1 are used for the purposes for processing seed.

7. the active agent combinations of claim 1 are used for the purposes for processing transgenic plant.

8. the active agent combinations of claim 1 are used for the purposes of the seed for processing transgenic plant.