TW200926984A - Ternary active compound combinations - Google Patents

Abstract

The invention relates to active compound combinations, in particular within a fungicide or insecticide composition, which comprises (A) 3, 4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide and (B) imidacloprid and (C) one insecticidal or fungicidal active compound. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi and/or microorganisms and/or pests of plants or crops, to the use of a combination according to the invention for the treatment of plant propagation, to a method for protecting a seed and not at least to the treated seed.

Description

200926984 6. INSTRUCTIONS OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention relates to active compound compositions, particularly fungicidal or insecticidal compositions, which comprise (A) 3,4-dichloro-N-(2- Cyanophenyl)_5-isoindole 5' decylamine (commonly known as Isotianil accession number 224049-04-1) and (B) imidacloprid and (C) an insecticidal or A fungicidal active compound. Further, the present invention relates to a method for the therapeutic or prophylactic control of phytopathogenic fungi and/or microorganisms and/or pests of plants or crops, the use of the composition of the present invention for treating plant propagation materials, and methods for protecting seeds and It does not stop at 10 treatment seeds. [Prior Art] It is known that (A) 3,4-dichloro-N-(2-cyanophenyl)-5-isoindole has fungicidal and insecticidal properties. Furthermore, it has been found that isoxazolecarboxylic acid derivatives are not suitable for protecting plants against unwanted phytopathogenic fungi and microbial attack (US-A 5 240 951 and JP-A 06-009 313). The compound (A) of the present invention is suitable for initiating plant defense against undesired phytopathogenic fungi and microbial attack' and as a microbicide to directly control phytopathogenic fungi and microorganisms. Further, the compound (A) also has an activity against pests which damage plants 20 (WO 99/24414). The compound (A) 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolylcarbamide and its preparation are disclosed in W〇 99/24414. The activity of this compound is good; however, it is sometimes unsatisfactory at low dosages. Compound (B) is isodam, a compound described in ΕΡ-Α0 192 060 3 200926984 insect active compound. Compound (c) is selected from the group consisting of the following fungicidal and insecticidally active compounds: ethiprole (as known from DE-A 196 53 417), fipronil (by EP-A0 0295) Known in 117), thiacloprid (known in EP A 0 235 725), spinosad (known in EP-A 0 375 316), thifluzamide ( (S)-3-Chloromethyl-4-[l,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl} Ν2-(1-methyl•2-mercapto-l-ethyl) ugly amine (known from EP-A 1 006 107) and N-[2-(l,3-dimercaptobutyl) Phenyl]-5-fluoro-1,3-dimethyl-1Η-«biazole-4_decylamine (known from WO 03/010149). The binary composition of the compound (C) and one of the compounds (C) is described in the following references (W0 2005/122796; ΕΡ-Α 0 871 362, W02005/036966, WO 1999/060857; W0 2007/ 101542; W0 2006/114212). It is also known that the combination of isostanib and new smoke tests is suitable for controlling phytopathogenic fungi (W0 2005/009131). Furthermore, 'because the environmental and economic requirements for today's fungicides and insecticides continue to increase (about, for example, scope of action, toxicity, selectivity, application rate, residue formation and suitable preparation capacity)' and because, for example, The problem of resistance to active compounds develops a continuous work that at least in some respects has new fungicidal and insecticidal agents that go beyond the advantages of their known counterparts. SUMMARY OF THE INVENTION The present invention provides active compound compositions which, in certain aspects, achieve at least the stated objectives at 200926984. Ο 10 15

20 Surprisingly, it has been found that the compositions of the present invention not only provide a broad-spectrum effect on the additional enhancement of the phytopathogenic fungi and/or microorganisms and/or pests controlled by the ''and also extend the compound (Α) in two respects) Synergistic effects of the range of action of the compound (Β) and the compound (C). First, the application amount of the compound (Α), the compound (Β), and the compound (C) is lowered and the effect is still equally good. Second, the composition achieves a high degree of phytopathogenic control even when three individual compounds have become completely ineffective in this low application range. Thus, on the one hand, the spectrum of plant pathogens that can be controlled is substantially broadened, on the other hand, the safety of use is increased. However, in addition to the actual synergistic effect on fungicidal and insecticidal activity, the pesticidal compositions of the present invention have had additional surprisingly advantageous properties which may also be described more broadly as synergistic activity. Examples of such advantageous properties may be mentioned: more effective killing of other phytopathogenic fungi and/or microorganisms and/or pests, such as resistant strains; reduction of active ingredients The amount of application; the control of pests in the present day; even under the low application rate of the compound without any fineness; favorable behavior during formulation or application, such as grinding, sieving, emulsifying, dissolving or dispersing; Increased storage stability; qualitative increase in light; more favorable degradation of toxicity or ecotoxic behavior; improved characteristics of useful plants, improved yield of roots, more developed roots, increased tillering, increased planting, and leaf harvesting Large, basal leaf death is lower, tiller is stronger, color is greener, fertilizer demand is lower, seed needs /, some

Pm #4" Less tiller, more tillering, earlier opening, earlier maturity, less plant buds, increased germination growth, 5 200926984 increased plant vigor and early germination; or anyone familiar with the technology Familiar with him. 〃 - The composition according to the invention may also provide improved and secretive properties to the compounds used. In fact, even some (4) fungicidal compounds do not have any or satisfactory systemicity. These compounds can still exhibit this property in the compositions of the invention.

In the same manner, the composition of the present invention can increase the persistence of the fungicidal effect of the active compound used. D It has also been found that the compound (A), the compound 10 (B) and the compound (Q against phytopathogenic fungi and/or microorganisms and/or pests are more than a single compound (4), compound (B) and compound alone or in combination. (C) or a binary mixture as described (WO 05/009131) is more effective. Another advantage of the composition of the invention is that increased efficacy can be achieved. Thus the invention provides compositions comprising: 15 (A) 3,4-di-gas-N-(2-cyanophenyl)-5-isoindolecarboxamide, and (B) isotamin, and cerium (C) additional active compound, consisting of the following Selected from the group of true halogen and insecticidal active compounds: ethiprole, fipronil, thiacloprid, spinosad, thifluzamide, S)-3-chloro->^-{2-methyl-4-[1,2,2 2-tetrafluoro-1-(difluoromethyl)ethyl]benyl}-N2-(l - Methyl-2-methyl chloroethyl) ugly amine and hydrazine-[2.(1,3-dimethylbutyl)phenyl]fluorene"} dimethyl-1 oxime-pyrazole-4 -carbamamine. For the compound (Β) and most of the (C) group of compounds, we mean the first of 2003, 200926984 The Pesticide Manual, version 3. Compound (c) is listed under the common name. If there is no common name on the priority date of the application, it is listed under the IUPAC-name of compound (C). The series is as follows: δ (A) 3,4-chloro-N-(2-cyanophenyl)-5-isoindole. Sesylamine and compound (B) isotamin and compound (C) Binger clear,

Q 10

15 Q s s (A) 3,4--milk-N-(2-cyanophenyl)-5-isoindole and compound (B) isotamin and compound (C) Fenpney , • Compound (A) 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolylcarbamide and compound (B) isodamide and compound (C) thiacloprid, • Compound ( A) 3,4_di-gas-N-(2-cyanophenyl)·5-isothiazolylamine and compound (Β) isotamin and compound (C), chlorpyrifos, • compound (Α) 3 , 4-diqi·Ν-(2-cyanophenyl)_5-isothiazolylcarbamide and compound (Β) isotamin and compound (C) cyanofluorin, • compound (A) 3,4-di Chloro-indole-(2-cyanophenyl)·5-isothiazolylamine and compound (Β) isotamin and compound (C)(S)-3-气-Ν1 - {2-mercapto-4_ [1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}_N2_(1-indolyl-2-methylsulfonylethyl)decylamine, • Compound ( A) 3,4-dichloro-indole-(2. cyanophenyl)_5-isothiazolylamine and compound (Β) isotamin and compound (C) N-[2-(l,3-di Nonylbutyl) phenyl]-5-fluoro-i,3-dimercapto-1H is more than sal-4-carboxamide. The weight ratio of the active ingredient compound is selected to achieve the desired (e.g., synergistic effect). In general, the 'weight ratio' is based on the particular active compound. In general, the weight ratio between any two compounds (not related to each other) is from 20 200926984 100 : 1 to 1: 100 ' preferably from 75: 1 to 1: 75, more preferably 50: 1 to 1: 50. Best 25: 1 to 1: 25. Between the two compounds. The other weight ratios (independent of each other), which can be gradually increased according to the present invention. The order of administration is '250: 1 to 1: 250, 200: 1 to 1: 5 200, 150 : 1 to 150 : 1. Additional weight ratios between the two compounds (independently of each other), which can be used in accordance with the present invention in a preferred order of giving, 9:1 to 1: _90, 80:1 to 1:80 70: 1 to 1: 70, 6:: 60, 40: 1 to 1: 40, 30: 1 to 1: 30, 10: 1 to i: 1〇, 5: : 5, ίο 4 : 1 to 1 : 4, 3 : 1 to 1: 3 . The compound (A), the compound (B) and the compound (C) may be in the form of tautomers. The formula is present, and even if it is not specifically mentioned in each case, the compound should be understood to include the corresponding tautomerisms above and below. Form of matter (when applicable). The compound (A), the compound (B) and the compound (c) have at least one basicity capable of forming, for example, an acid addition salt, for example, with a strong mineral acid such as a mineral acid such as peroxy acid, sulfuric acid, nitric acid, Nitrous acid, phosphoric acid or hydrohalic acid, with strong & carboxylic acid, such as unsubstituted substituted such as dentate substituted iCi_C4 alkanoic acid, such as acetic acid, saturated or unsaturated dicarboxylic acid, such as oxalic acid, malonic acid , succinic acid, maleic acid, fumaric acid and o-dicarboxylic acid, hydroxycarboxylic acid such as 2-indole ascorbic acid, lactic acid, tartaric acid and citric acid or alum acid, or with an organic sulfonic acid such as unsubstituted or substituted, such as halogenated Substituted Ci_c alkane or arylsulfonic acid, such as formazansulfonic acid. The compound (A), the compound (C) and the compound (C) have an acidic group to v, which can, for example, form a salt such as a metal salt such as a metal or an alkaline earth metal salt such as sodium. Potassium or magnesium salt, 8 200926984

10 15

20 salts with ammonia or organic amines such as morpholine, piperidine, stagnation, mono-di- or tri-low-carboamine, such as ethyl, diethyl, trimethoprim- A propyl-amine, or a mono-, di- or tri-hydroxy lower alkylamine such as mono-, di- or triethanolamine. In addition, corresponding internal salts can be formed as desired. In the context of the present invention, it is preferred to obtain an agrochemically advantageous salt: in terms of the close relationship between the compound (A), the compound (B) and the compound (C) free form and the salt form thereof, When it is advantageous, the compounds (Α), the compound (Β) and the compound (c) or their hybrids referred to above and below are also included in the corresponding salts or the free compounds (A) and (b), respectively. And the compound (Q. equivalents are also applied to the tautomers of the compound (A), the compound (B) and the compound (C) and salts thereof. According to the invention, the "composition" - the representative compound (4), the compound (8) And various compositions of the compound (C), such as a single "premixed" mouth, and a combination of a mixture of active compounds, such as "minus", when in a sequential manner, The use of a single activity 'that is, in a reasonably short period of time, such as hours or days, wheat. Preferably, the order of administration of the compound, the compound, and the a (C) is not absolute to the operation of the present invention. Inventing "pathogen" - the word system represents any part of a plant or plant All creatures that know the wound. =ίInvented "fungi" - the word system represents all fungi and algae organisms. Γί明 The term "phytopathogenic fungi" refers to all fungi and algae organisms that cause plant damage. Ascomy 9 200926984 (Basidiomycota), chytridiomycota, Deuteromycota, Glomeromycota, Microsporidia, Zyg0myC〇ta and Anamorphic Fungi). Examples of vines are _ n(〇〇myC〇ta). 5 ❾ 10 15 ❾ The term "microorganism" according to the present invention is used to refer to all bacteria and protists. The case has a root bacterium (Plasm〇di) 〇phoromycetes. According to the invention, the term "virus" refers to all viruses which cause damage to any part of a plant or plant. Examples are DNA_, RNA & DNA* rna retroviruses and subvirai agents. The term "pest" refers to any acheiminthes and panarthropoda that cause damage to plants or plants. Examples of Nematoda (Nemat〇da), Arthropod (Arthopoda), Hexap〇da and Arachnida The active compounds in the compositions of the invention have potent microbicidal, fungicidal and killing properties. Insect activity and can be used in crop protection, raw material protection, veterinary industry, animal husbandry to control unwanted phytopathogenic fungi and/or microorganisms and/or pests, and as a household insecticide. In the composition of the invention, the fungicidal compound can be used for crop protection, for example, controlling phytopathogenic fungi and/or microorganisms and/or pests, such as root bacteria, oomycetes, chytrids, zygomycetes, ascomycetes, and burdens. Bacteria and incomplete bacteria. In the compositions of the present invention, insecticidal compounds are useful for crop protection, such as controlling phytopathogenic pests. In the composition of the present invention, the bactericidal compound can be used for crop protection, controlling microorganisms such as Pseudomonas, Rhizobium, Enterobacter, Corynebacterium 20 200926984 and Streptomyces 10 15 〇20 The fungicidal and killing of the present invention Insect combination and / (4) H is a method for treating plant and/or pests on plants or crops, including applying the composition of the present invention to the fruits of seeds, plants or plants: The soil that the worm wants to grow. Real or plant growth or according to the invention, for example, all plants and plant groups, for example; two: wild type = plant breeding species (including naturally occurring planting species (whether or not plant species or plants)培育 权利 及 及 及 及 藉 藉 藉 藉 藉 藉 藉 藉 藉 藉 藉 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习 习Gene markers or by biological adaptation, due to lean plants). Knowing methods (including basal trunks, flowers, fruiting bodies, fruit stalks and such as leaves, needles, stems, objects, and sexual and sexual reproductions f, such as cuttings, balls μ. Stems and The seed also belongs to the part of the plant. The second board disaster, walking, according to the invention "plant thin matter" - the word system represents all plants that can be ... or sexual reproduction f. Plant reproductive material ^ real ^ π 200926984 pod, sub- Cuttings, bulbs, roots U, going to the community ^., w ^ walking, seeds, fruits, glutinous solids, tubers and seedlings. And:=:=== 〇10 15

= amount of the original compound. "Effective (but transgenic) amount" = = the amount of the composition of the invention is sufficient to satisfactorily or completely eliminate the true g disease of the plant, and in the other aspect does not cause any poisoning symptoms . The effective dose can generally vary over a wide range. The tanning agent is determined by a number of factors, such as the fungi, plants, climatic conditions, and active compounds of the compositions of the invention to be combated. Among the plants which can be protected by the method of the present invention, the main farm crops such as corn, soybean, cotton, rapeseed such as Brassica napus (rape) turnip, Brassica napus (such as mustard) and Abbey can be mentioned. Brassica canola (Brassica carinata), rice, wheat, sugar beet, sugar cane, oats, rye, barley, granules, millet, triticale, flax, vines and various fruits and flora of vegetables such as Rosaceae (eg, pome fruits) , for example, apples and pears, as well as stone fruits such as apricots, cherries, almonds and peaches, berries such as strawberries), Ribesioidae sp., juveniles (jUgiandaceae sp.), birchaceae (Betulaceae sp.), lacqueraceae (Anacardiaceae sp.) , Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (eg banana tree and planting), Rubiaceae sp. (eg coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (eg lemon, Orange and grapefruit); Eggplant 12 20 200926984 Branch (S〇lanaceaesp.) (eg tomato, potato, pepper, eggplant, colza), Liliaceae sp, Compositae ((3)-continental sp· 5 Ο 10 15 ❹ Lettuce, artichokes and chicory - including root chicory, chicory or common chicory), J. jmbemferaesp. (eg carrot, bud, sprout and radish sprout), Cucurbitaceae sp. (eg gherkins - including kimchi cucumber, pumpkin, watermelon, zucchini and cantaloupe), Amaceae sp (such as Yanghui and amaranth), Cruciferae sp (such as white cabbage, red cabbage) Vegetables, broccoli, broccoli, Brussels sprouts, cabbage, kohlrabi, white radish, buds, and leeks, LegUnain〇sae sp (such as peanuts, peas and beans - such as kidney beans and broad beans), Chenopodiaceae sp.) (eg, calendula, leaf beet, spinach, beet), Asteraceae sp. (eg, hollyhock), cruciferous (9) anal, also north, sp.) (eg, white cabbage, red cabbage Dish, broccoli, broccoli, Brussels sprouts, cabbage, kohlrabi, white radish Bu and fragrant flowers, rapeseed, mustard, wasabi, cress), Fabacae sp. (such as peanuts and beans), Papilionaceae sp. (such as soybean), Malvaceae (Malvaceae) (eg okra), Asparagaceae (eg asparagus); horticultural and forest crops; ornamental plants; and genetically modified homologs of these plants. The treatment methods of the invention can be used to treat genetically modified organisms (GMOs), such as plants or seeds. A genetically modified plant (or a genetically transplanted plant) is a plant in which a heterologous gene has been stably integrated into the genome. The term "heterologous gene" essentially refers to the provision or combination of a gene to a plant, and when introduced into the nucleus, chloroplast, or mitochondrial genome, by expressing a favorable protein or peptide or by downregulating or Repressing the presence of other genes in plants (using 13 20 200926984 such as antisense technology or co-suppression techniques or RNA interference-RNAi-technology), for new or improved agronomic or other properties of altered plants. A heterologous gene located in the genome is also known as a transgenic gene. A transgene that is defined by its specific location in the plant genome is referred to as a transformation or gene transfer event. ❹ 10 15

The treatment of the present invention may also result in a super-additive ("synergistic") effect depending on the plant species or plant variety, its location and the growing environment (soil, climate, vegetation period, diet). Thus, for example, reducing the amount of application and/or increasing the activity broadness and/or increasing the activity of active compounds and groups of people usable in the present invention, preferably plant growth, increasing resistance to high or low temperatures, increasing drought Or water or soil salinity tolerance, increased opening performance, easier harvest, accelerated ripening, higher yield, larger fruit, larger plant height, greener leaf color, more bathing, harvesting products Good quality and/or higher nutritional value, higher sugar content in the fruit, better storage stability and/or processing properties of the harvested product are all possible, which is actually expected to be useful. The active compound compositions of the present invention may also have potentiating effects on plants at a particular rate of application. Therefore, it is also suitable for initiating plant defense systems against unwanted phytopathogenic fungi and/or microbial and/or viral attacks. If appropriate, this may be one of the reasons for increasing the activity of the compositions of the invention, for example against fungi. To strengthen a plant (inducing resistance) substance, it is understood that (in this context) such a substance or substance composition capable of stimulating a plant defense system, such that when subsequently undesirable phytopathogenic fungi and/or microorganisms When the virus and/or pests are inoculated, the treated plants exhibit a substantial degree of resistance against these unwanted phytopathogenic fungi and/or microorganisms and/or viruses and pests. In the case of the present invention, unwanted plantings//microorganisms and/or silks are understood to mean phytopathogenic fungi, bacteria and viruses and/or pests. Therefore, the substance of the present invention can be

❹

15 Q 20 is used to protect plants against the above pathogens within a specified period of time after treatment. After the treatment of the plant with the active compound, the period of protection is effective, and it is only 1 to 10 days, preferably 1 to 7 days. Preferably, the plant and plant breeding lines treated in accordance with the present invention comprise all plants (whether derived from breeding and/or biotechnological methods) having secretary, useful properties to the genetic material of such plants. Preferably, the plants and plant cultivars treated in accordance with the present invention are resistant to one or more biotic stresses, i.e., the plants exhibit resistance to animals, micro-substances. The insects have, for example, better defense against nematodes, insects, worms, phytopathogenic fungi, parvoviruses and/or viroids. Also preferred are plants or plant cultivars which are treated according to the invention, or which are capable of a variety of abiotic stresses. Abiotic stress conditions can include, for example, shovel dryness, low temperature exposure, heat exposure, osmotic stress, flooding, soil salinity G mineral exposure increase, ozone exposure, limited nitrogen nutrient availability, limited sulphur nutrient availability, shading effect. Plants and plant cultivars which are preferably treated according to the invention, and the like, are characterized by plants which increase the yield characteristics. The yield of the plant is increased: 4 self-improving plant physiology, growth and development, such as water use efficiency, j, 'original rate, promoting nitrogen utilization, promoting carbon assimilation, promoting photosynthesis, increasing water retention rate and accelerating maturation. Further, by improving the plant structure (under stress-free conditions), including, but not limited to, early flowering, = and assimilation, the production of hybrid seed, seedling vigor, number and distance, and roots of 15 200926984 Growth, seed size, fruit size, pod size, number of pods or ears, number of seeds per pod or ear, seed weight, increased seed filling, reduced seed spread, reduced pod splitting and resistance to volts. Additional yield characteristics include seed composition, such as 5 carbohydrate content, protein content, oil content and composition, nutritional value, reduced anti-nutritional compounds, high processability, and better storage stability. Examples of plants having the above characteristics are listed non-exhaustively in Table A. Crop characteristics GMO reference total water utilization rate is W02000/073475 All nitrogen utilization rate is W01995/009911 All nitrogen utilization rate is WO1997/030163 All increased photosynthesis is W02003/000066 Soybean nematode resistance No WO1995/020669 Rapeseed reduced pod splitting is W02006/009649 Soybean bud resistance No W02006/125065 Lettuce bud resistance No W01997/046080 Sclerotinia sclerotiorum resistance No WO2006/135717 Other 5 Sclerotinia resistance No W02006/046861 Lettuce gray mold resistance No US20070022496 E. faecalis resistance No W02004/049786 Cucumber yellowing filovirus resistance No W02002/022836 Capsicum virus resistance No W02006/038794 16 200926984 栌可^ The plants treated by the present invention are heterozygous or hybrid vigor Parent plants, which usually record high 1 = resistance, such plants are typical ^ 2, and another self-bred male fertility mother strain (male strain) = planter: typically plants from male plants infertile Plants harvested and ^ ί pregnant can sometimes (for example, corn) remove male reproductive organs (or males by detassehng) ) To yield green ❹ 15 'but more typically male plant sterility in the plant genome based society of genetic determinants in the fruit. In the case where the seed is made from the hybrid & product, it is typically used to determine that the fertility of the male plants of the hybrid plants is fully restored. This can be accomplished by determining that the male parent has the appropriate reproductive recovery gene and can restore the male fertility of the hybrid plant (containing the genetic stator responsible for the infertility of the male plant). The genetic stator of the male strain *pregnant is located in the cytoplasm. Examples of cytoplasmic male infertility (CMS) are described, for example, in the rapeseed species (w〇 92/05251, WO 95/09910, WO 98/27806, WO 〇 5/002324, WO 06/021972, and US 6,229,072). However, the legacy of the male infertility is also located in the genome of the nucleus. Plants that are infertile in male plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful method for obtaining a male plant infertile plant is described in WO 89/1 396, in which, for example, a ribonuclease such as a barnase is selectively expressed in the tapetum cells of the stamen. The fertility (eg, w〇91/02069) can then be restored by the tapetum cells present in the ribonuclease inhibitor (eg, barstar). Plants and plant cultivars treated according to the invention (may Plants are tolerant to plants by plant technology, such as genetic engineering, such as genetic engineering, and even if the plants are tolerant to one or more of the herbicides administered. Such plants can be obtained by gene transformation or by selecting plants containing the mutation to confer tolerance to the herbicide. 5 ❹ 10 15 ❹ Herbicide-tolerant plants are, for example, glyphosate-tolerant plants, even if the plants are tolerant to the herbicide Jialin or its salts. For example, a Jia-resistant plant can be obtained by transforming a plant with the enzyme 5 - dilute acetonylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacteria Salmonella typhimurium/yp/n'wwr/wm (Comai et al., 1983, Science 221, 370-371), Bacillus licheniformis CP4 gene (Barry et al., 1992, Curr. Topics Plant Physiol. 7, 139-145), genes encoding petunia EPSPS (Shah et al., 1986, Science 233, 478-481), tomato EPSPS (Gasser et al. , 1988, J. Biol. Chem. 263, 4280-4289) or Goosegrass EPSPS (WO 01/66704). It can also be a mutated EPSPS as described in, for example, EP 0837944, WO 00/66746, WO 00/66747 or WO 02/26995. The phosphatase-resistant plants can also be obtained by expressing a gene encoding a phosphatase oxidoreductase as described in U.S. Patent Nos. 5,776,760 and 5,463,175. The galvanose-resistant plants can also be obtained by expressing a gene encoding a methionine-transferase enzyme as described in WO 02/36782, WO 03/092360, WO 05/012515 and WO 07/024782. The galangin resistant plants can also be obtained by selecting the 20 200926984 plants containing the above-mentioned genes which are naturally occurring as described in WO 01/024615 or WO 03/013226. Other herbicide-tolerant plants are, for example, plants which inhibit the resistance of the enzyme face amine amine amine synthase to herbicides, such as bialaph〇s, phosphinothricin or gluf〇sinate. ). Such plants can be obtained by expressing an enzyme which removes the herbicide toxic enzyme or inhibits the resistant mutant glutamine enriched enzyme enzyme. An effective detoxifying enzyme is an enzyme encoding a glufosinate-ethyltransferase (e.g., a bar or pat protein from Streptomyces species). Plants which exhibit a foreign glufosinate-ethylidene-transferase are described, for example, in U.S. Patent Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 No. 7,112,665.

Other herbicide-tolerant plants are also plants that are tolerant to herbicides by inhibiting the enzyme hydroxyphenylpyruvate dioxygenase (HPPD). Hydroxyphenylpyruvate Dioxygenase is an enzyme that catalyzes the conversion of p-hydroxyphenylpyruvate (HPP) to urinary acid. Plants that are tolerant to HPPD-inhibitors can be transduced with a gene encoding a naturally occurring anti-HPPD enzyme, or a gene encoding a mutant HPPD enzyme, as described in WO 96/38567, WO 99/24585 and WO 99/24586. shape. Resistance to HPPD-inhibitors can also be obtained by transforming a gene encoding the formation of homogentisate with a specific enzyme, regardless of the inhibitory effect of the HPPD-inhibitor on the native HPPD enzyme. Such plants and gene lines are described in WO 99/34008 and WO 02/36787. The tolerance of plants to HPPD inhibitors can also be as described in WO 2004/024928, except for genes encoding HPPD-tolerant enzymes, by gene transduction with the enzyme prephenate 200926984 dehydrogenase Plants to improve. 5 Ο 10 15 ❹ Further herbicide-resistant plants are plants that are tolerant to acetate lactate synthase (ALS) inhibitors. Known AL S -inhibitors include, for example, sulfonyl urea, imidazolinone, diazolopyrimidine, pyrimidinyloxy(thio)benzoic acid and/or sulfonylaminocarbonyltriazolinone herbicides . Mutations of different ALS enzymes (also known as acetyl-based acid synthase, AHAS) are known to be resistant to different herbicides and herbicide groups, for example in Tranel and Wright (2002, Weed Science 50: 700-712). And as described in U.S. Patent Nos. 5,6,5,11, 5,378,824, 5,141,870, and 5,013,659. The production of urea-resistant plants and imidazolinone-resistant plants is described in the United States.

Patent Nos. 5, 605, 011; 5, 013, 659; 5, 141, 870; 5, 767, 361; 5, 731, 180; 5, 304, 732; 4, 761, 373; 5, 331, 107; 5, 928, 937; and 5, 378, 824 And international application WO 96/33270. Other imipenem ketone plants are also described, for example, in WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351 and WO. In 2006/060634. Other sulfonyl urea- and imidazolinone-tolerant plants are also described, for example, in WO 07/024782. Other plants which are tolerant to imidazolinone and/or sulfonyl urea can also be used as described in, for example, U.S. Patent No. 5,084,082, U.S. Patent No. 5,084,082, U.S. Patent No. 5,773,702, and WO 99/057965 The lettuce in U.S. Patent No. 5,198,599 or the hollyhock in W001/065922 is obtained by inducing mutation production in the presence of a herbicide in selective cell culture or mutation breeding. Plants and plant cultivars (which can be obtained by plant biotechnology methods such as genetic engineering) which can also be treated according to the invention are insect-resistant genes. Transgenic plants, even if the plants are resistant to attack by specific target insects. These 5 plants can be obtained by gene transfection or by selecting plants containing the mutant to transmit this insect resistance. As used herein, "insect-resistant gene-transgenic plants" include any ◎ containing at least one transgene that encodes the following coding sequences: 1) from the genus Succulent (10,000 acz · / / (10) recognized insecticidal crystal protein or 10 its insecticidal part; for example, as listed by Crickmore et al. (1998, Microbiology and Molecular Biology Reviews, 62: 807-813), by Crickmore et al. (2005) on the nomenclature of toxins (Scorpion; s) toxins, online :http : //www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/) 15 updated, or its insecticidal part, such as the protein of the Cry protein

CrylAb, CrylAc, CrylF, Cry2Ab, Cry3Aa or Cry3Bb or an insecticidal portion thereof; or 2) an insecticidal crystal protein derived from S. cerevisiae or a portion thereof, which is in the second other species from S. cerevisiae crystal protein or a portion thereof There are two insecticidal properties, such as a binary toxin composed of Cry34 and Cry35 crystal proteins (Moellenbeck et al., 2001, Nat. Biotechnol. 19: 668-72; Schnepf et al., 2006, Applied Environm. Microbiol. 71, 1765-1774); or 3) hybridization comprising a portion of different insecticidal crystal proteins from S. cerevisiae 200926984 insecticidal proteins, such as the hybrids of 1) above or the hybrids of 2) above, for example Maize line MON98034 (WO 2007/027777) - manufactured CrylA.105 protein; or. 4) any of the above proteins A1) to A3), some of which, in particular, 1 to 10 5 amino acids are via additional amine groups Acid substitution, resulting in higher insecticidal activity against the target insect species, and/or expanding the range of affected target insect species, and/or because of the introduction of a coding DNA alteration during replication or transformation, such as Cry3Bbl protein of maize MON863 or MON88017, Or corn MI Cry3A protein of R604; 10 5) Insecticidal secreted protein or its insecticidal part from S. cerevisiae or Cactus cerewus, such as the vegetative insecticidal egg listed in the following: • White (VIP): htlp "Avww.lifesci. sussex.ac.uk/Home/Neil_Crickmore/Bl/vipiitml) 'eg a protein from the VIP3Aa protein species; or 15 6) a secreted protein from S. cerevisiae or Cactus, in the second from Suri or S. In the presence of a secreted protein, it is insecticidal, such as a binary toxin composed of VIP1A and VIP2A proteins (WO 94/21795); or 7) contains different secreted protein fractions from S. or Cactus. Hybrid insecticidal protein, for example, hybridization of the above 1) protein or hybridization of the above 2) protein; or 8) any of the above 1) to 3) proteins, some of which are in particular 1 to 10 amino acids via additional amine groups Acid substitution 'obtains higher insecticidal activity against the target insect species, and/or expands the range of affected target insect species, 22 200926984 and/or because the coding is still encoded during the replication of the insecticidal protein) Change (at the same time wood, 'for example Flowers (: D 102 square \ ^ 11 > 3 eight & protein. Of course, as used herein, any gene-transplanting plant containing the insect resistance encoding the above insects is also included. In one embodiment, the plant having any one of the above-mentioned types 1-8 of the gene combination of any of the 8 genus insects comprises more than one transgenic gene encoding the standard insect species, ## Use different egg-specific insect species for different purposes ί 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟 延迟Resistance to insect development, such as binding at different receptor binding sites in this worm. Plants and plant cultivars (which can be obtained by phytosanitary methods such as Geneguard) can also be used for abiotic stresses according to the date of this issue. Such plants can be obtained by gene transformation or by selecting plants containing the mutation to deliver this stress resistance. Particularly useful stress-tolerant plants include: ❹ a. Plants containing a transgenic gene that reduces the expression or activity of a poly(ADP-ribose) polymerase (PARP) gene in a plant cell, such as w〇00/04173 or EP 04077984.5 or Said in EP 06009836.5. b. Plants containing stress tolerance enhancing transgenic genes that reduce the expression or activity of a PARG-encoding gene of a plant or plant cell 20, as described, for example, in WO 2004/090140. c. a plant that contains a plant functional enzyme encoding a nicotine indoleamine adenine dinucleotide remedy synthetic pathway, a plant that is resistant to a transgenic gene, including a proguaninase, an acid sulphate transferase, Acid mononuclear 23 200926984 Adenylate transferase, nicotinic adenine adenine dinucleotide synthase or sucrose ribose transferase, such as, for example, ΕΡ 04077624.7 or W〇2006/133827 or As described in PCT/EP07/002433. 5 that the quantity, quality and/or storage stability of the harvested product and/or the specific component properties of the harvested product may also be altered by the plant and plant cultivars (which may be obtained by plant biotechnology methods such as genetic engineering) treated according to the invention. For example: ❹ 10 1) Synthetic modified house powder genetically transgenic plants, in terms of their physico-chemical properties, especially the linear powder content or linear powder/branched powder proportion, branching degree, average chain length The side chain distribution, viscosity, gelatinization strength, starch granule size and/or starch granule morphology have been altered compared to starch synthesized in wild type plant cells or cells, so it is more suitable for specific applications. The gene transfer plant produces a modified starch system disclosed in Example 15 Ο 97/26362 97/44472 98/40503 99/58654 00/08175 01/12782 03/071860 WO 95/04826, EP 0719338 96/19581, WO 96/ 27674

For example, EP 0571427, 96/15248, WO 97/11188, WO 97/42328, WO 98/27212 'WO 99/58690, WO 00/08185, WO 00/77229, WO 02/101059, WO WO 97/32985, WO 97/45545, > W099/58688, WO 00/08184, WO 00/28052 'WO 01/12826 ' WO 2004/056999

WO WO WO WO WO WO WO WO WO 2005/030942, WO 2005/030941, WO 2005/095632,

WO 2005/095617, WO 2005/095619, WO 24 20 200926984

2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 5 ❹ 10 15 Ο

2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP 07090009.7, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, US 6734341, WO 00/ 11192 'WO 98/22604 'WO 98/32326 > WO 01/98509, WO 01/98509, WO 2005/002359, US 5824790, US 6013861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026, WO 97/20936. 2) Synthesis of non-starch carbohydrate polymers or synthesis of genetically modified plants of non-starch carbohydrate polymers having mutative properties (compared to genetically modified wild-type plants). Examples are plants for the production of polyfructose, in particular inulin and polyfructose-types as disclosed in EP 0 663 956, W096/01904, WO 96/21023, WO 98/39460 and WO 99/24593, as disclosed in WO 95/31553, US 2002031826 , US 6,284,479, US Pat. No. 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808, and WO 00/14249, which produce al, 4 polyglucose plants, disclosed in WO 00/73422 to produce α-1, 6 a plant having a chain of alpha-1,4 polydextrose, disclosed in WO 00/47727, ΕΡ 06077301.7, US 5908975, and ΕΡ 0728213 for producing a branched poly 25 20 200926984 gluconate (alternan) plant, 3) gene production of hyaluronic acid Plants are disclosed, for example, in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006304779, and WO 2005/012529. ❹ 10 15 植物 Plants and plant cultivars (which can be obtained by plant biotechnology methods such as genetic engineering) which can also be treated according to the invention are, for example, plants having cotton plants with altered fiber properties. Such plants can be obtained by genetic transformation or by selecting plants containing mutations that impart a change in the properties of the fiber, and include: a) Plants such as cotton plants, as described in W098/00549, containing variant forms of fiber synthase a gene, b) a plant, such as a cotton plant, as described in WO2004/053219, containing a variant form of the rsw2 or rsw3 homologous nucleic acid gene, c) a plant, such as a cotton plant, as described in WO 01/17333, having a sucrose phosphate synthase Increased performance, d) plants, such as cotton plants, as described in WO 02/45485, 'having increased expression of the sugar synthase, e) plants such as cotton plants, in which plasmodesmatal gating of the basal fibrocytes The timing changes as described in Example 4 WO2005/017157, via fiber-selective PI, 3-glucose down-regulation, f) plants 'eg cotton plants, fibers with reactive variation' eg eg in 2006/136351 The 'trans-N-acetyl hydrazinoyltransferase 26 20 200926984 gene includes the expression of the nodC and chitin synthase genes. 5 ❹ 10 15 Plants and plant cultivars (which can be obtained by plant biotechnology methods such as genetic engineering) which can also be treated according to the invention are, for example, plants of oilseed rape or related rapeseed having oil-oil property. Such plants can be obtained by genetic transformation or by selecting a plant containing a mutation to deliver this fiber-property variation, and include: a) a plant, a canola plant as described in US 5,969,169, US 5,840,946 or US 6,323,392 or US 6,063,947 Said to produce a fat having a high oleic acid content, b) a plant, a canola plant, as described in US 6,270,828, US 6,169,190 or US 5,965,755, which produces a fat having a low linoleic acid content, c) a plant A canola plant, for example, as described in U.S. Patent 5,434,283, produces a fat having a low amount of saturated fatty acids. A particularly useful gene-transforming plant that can be treated according to the present invention is a plant containing a combination of a morph or a morph, which in the United States is a non-regulated application to the United States Department of Agriculture (USDA) Animal and Plant Health and Quarantine Service (APHIS). , whether or not such applications have been granted or are still pending. This information is readily available at any time from APHIS (4700 River Road Riverdale, MD 20737, USA), for example at its website (URL http://www.aphis.usda.gov/brs/not_reg.html). After the application in this application, the non-regulated application that has been granted in the APHIS application or APHIS is the application for the following information listed in Table B:

- Application: The identification number of the application. For a description of the technical status of the transformation, refer to this application number, see the individual application documents of APHIS, such as the APHIS 27 20 200926984 website. These descriptions are incorporated herein by reference. - Extension of application: refers to the extension of the previous application request. - _Organization: The name of the entity making the application. - Controls: The species of plants involved. 5 _Transformation: The characteristics of plants conferred by genetic transformation. - The name of the article or the product: the name of the object without regulatory requirements (sometimes referred to as the plant) ❹ APHIS document: A document published by APHIS relating to the application and available to APHIS. 28 200926984

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Finally EA & decided Β • 〇〇.ε 〇〇〇ε 'ο 00 ο ε _ Ο vo ο .sm 〇s inch oai .ε 〇\ 〇• ε Ό 〇(Ν | 00 — σ·\ 〇r- υ ^ α! 1 1 Οη —1 CN 〇, I 卜o —| oi oo »—' O 〇1 oo ^ On O m 〇m 1 m 〇cn 1 σ\ ο 〇〇 — Ον Ο 00 — ΟΝ Ο ΟΟ — Ον Ο Γ**·» ' Os O — ΟΝ Ο Step EA * or wind assessment • a Ρί m 〇 OO »ν 2 〇^ ng Τ veT <N Ο ω ω Ρ-ι Bu cs T—^ OO Bu B 〇g υ υ & Ν Ν Q Q Q P Ο Ο Ο Ο Ο Ο Ο Ο 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h h V〇t/l C/D Η m 秣, system h> 钋莒蚋 钋莒蚋 K · · K K K 钋莒蚋 Η Η Η Η Η Η • • • • • • • • • • 想 管制 管制 管制 管制 管制 管制 管制 管制 管制 管制4< ω!Γ Difficulty C cd 00 〇2 ο c cd Μ 〇>〇?>〇> cW G 〇>〇〇> U tu 5b < UC/3 cg -3 S ω ≪L> ιΠ ίΛ c PJ ο s ® <υ ^ 2 on 2 Ο cu ο s 1 00 叫·Φ»解'sO ο :3 Os Ο 〇- 〇Οι—Η ο οο Cu 1—Η 〇ο ο CL, 〇cx o α. ο cx »—^ o α- 〇〇〇VD m inch CN Φ- 1 00 ON CS οο 〇Ν CS 00 ON <s oo On 1—^ 1 ΟΟ ON o 1 00 ON ΓΛ 1 卜 ON m 1 〇 sm 1 卜 ON 00 °? ΟΝ ΓΛ ο inch 1 <N cn can be inch in inch 1 ώ PQ ώ PQ ώ ώ ώ ώ CQ 33 200926984

Final EA & Decision 97-287-01p_com I 97-265-Olp com ί 97-205-Olp com 97-204- Olpcom 97-148- Olpcom 97-099-01 p_com 97-013-Olp-com 97-008 -01p a com 96-317- 01p_com 96-291- 01 p com 1 r — preliminary EA **** or risk assessment FR notification transformation line or strain 5345 | CBH-35 1 T45 RBMT21-129 &: RBMT21 -350 ! RM3-3, RM3-4, RM3-6 GA21 _i Events 3 1807 & 31808 c 〇\ 00 1 1 v〇 inch — On 1 ο α o MON802 DBT418 gene transfer phenotype lepidopteran resistance 簖^ ±1 h « glufosinate-tolerant CPB & PLRV-resistant male plants infertility 1_ 嘉磷塞耐黎^±1 骚油 properties change 1 l¥ ±i 〇 tons pq & 螟 corn 螟 resistance control 1_ 番佑玉来油菜 potato corn cotton soybean corn corn body 1_ Monsanto AgrEvo AgrEvo Monsanto Bejo 1_ Monsanto Calgene Du Pont Monsanto DeKalb Application No. *** Application 97-287-01p 97-265-01p 97-205- 01p 97-204-01p 97-148-01p 97-099-01p 97-013-01p 97-008-01p 96-317-01p 96-291-01p B-47 B-48 B-49 B-50 B- 51 B- 52 B-53 B-54 B-55 B-56 34 200926984 Final EA & ε 〇〇〇 〇 CN | Ον Ο 96-068-Olp—com 96-051- 01p_com 96-017-01 p_coin 95- 352- Olpcom 95-338-01 p_com 95-324-01 p_com 95-256-Olp-com 95-228-Olp-com Initial EA **** or Risk Assessment FR Notification of Transgenic Lines or Plants 1 Additional LAVRSAVR 〇〇Λ 〇〇Λ »<111 Θ inch inch Ο heart Ο Ο inch r-b if5 (S cs ^ <<< 1 55-1, 63-1 L... On O 〇 - OO 00 oo CZW-3 1_ 〇2 t〆1 S 7^ 1—^ m 19-51a MS3 gene phenotypic fruit ripening changes glufosinate tolerance PRSV resistance European corn borer resistance % ±1 δ彡CPB Resistant fruit maturity change performance 醯 基展素 财 承 雄 雄 雄 雄 翁 翁 翁 翁 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Du Pont Plant Genetic Systems Application No. *** 92-196- 01 p 95-093- 01 p Application 96-248-Olp 96-068-Olp 96-051-01p _1 96-017-01p 95-352 -01p 95-338-01p 95- 324-01p 95-256-01p 95-228-01p B-57 B-58 1 B-59 B-60 B-61 B-62 : B-63 ______ B-64 1 _1 B-65 35 200926984

Finally EA & decision 95-195-Olp-com I 95-179-Olp a com 95-145- 01p_com 95-093- 01p_com 95-053- 01p_com 95-045- 01p_com 95-030-Olp a com 94-357 - 01p_com 94-319- 01p_com > ε 〇〇〇〇ο cn 1 4 3 ΟΝ Ο Step EA * or wind evaluation > ο > Transgenic line strain; Btl 1 ί_ 2 additional FLAVRSA strain Β 16 MON 8010 8338 1445, 1698 20 Extra FLAVRSA strain 14, 14, Event25 Event 176 531, 757, 1076 ±immma ±1 id 'made id 呆 稼 l l • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Face ¥ Κ Κ 穿 穿 ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( Μ 1. Ο.S Ο a Χϊ a cd a cd c cj ο a 〇><υ ζΛ c Λ α> cd CO C Ο s W) G 〇ίΛ C 〇ο 00 ω CO C o ΪΖ; WUQS υ Ο s 92-196- Οΐρ ΟΝ 1—^ 嗓·φ" A3 ΟΝ 申请 Apply ex ο I irv Os r—N D. Ο I ΟΝ α α. Ο I un inch cu H ot cn Os Qh o 1 Oh o 1 κη inch D- Ο 1 Ο m Cu 〇1 Ο ι ι Ον Ex o oo o 1 vr\ 1 κη I 〇1 〇1 ο 1 ο 1 cn ro Q\ Os κη ON i〇Os ON ON KTi ΟΝ inch Cn inch 〇 \ B-66 Β-67 Β-68 B-69 B -70 B-71 Β-72 B-73 Β-74 B-75 36 200926984

Final EA & Decision 94-290-Olp com 1 94-257- 01p_com 94-230-Olp-com 94-228-Olp-com 94-227- Olpcom 94-090- 01p_com 93-258· Olp-com 93- 196· Olp—com 92-204- 01p_com 92-196-Olp com Initial EA **** or Risk Assessment C3 <N j 4 ugly Os O 94-228-Olp ea ί 92-204- Olpea FR Notice 10- March-1995 κη On cs 3·October-1994 22. February 94 13-December-1994 1 19-October-1992 1 Transformed line or mouth B, Da, F _ BT6, BT10, BT12, BT16, BT17, BT18, BT23 9 additional FLAVRSAVR strain 1345-4 Line N73 1436-111 pCGN3 828-212/86- 18 & 23 40-3-2 BXN ZW-20 > ^ <> J < Tu 00 gene transfer phenotype 1_ Degas, 驷 spectrum coleoptera resistance fruit ripening change fruit ripening change fruit ripening change oil properties change 1_ Jia Phosin tolerant bromoxynil tolerant WMV2 & ZYMV resistant fruit ripening change q Controls Fan Tuo Ma Ling Tu Fan Tu Fan Fan Fan Temple Rape Soybean Cotton Pumpkin Panyou Agency 1_ ^ -〇Cd S 〇S ^ N cu ' Monsanto Calgene 1 DNA Plant : Tech Calgene Calgene 1_ Monsanto Calgene XI ο '2 D Calgene 1 Extension Application No. *** 92-196- 01p 92-196- 018 Application 1_ 94-290-Olp 94-257-01p 94-230-01p 94-228-01p 94-227-01p 94- 090-01p 93-258-01p 93-196-01p 92-204-01ρ 1 92-196-01p 1 B-76 B-77 B-78 B-79 B-80 B-81 B-82 B-83 Β -84 B-85 37 200926984 A particularly useful series of plants containing a single morph or morph composition is, for example, in a database of national or regional regulatory authorities (see for example http://gmoinfojrc.it/gmp-browse. Aspx and http://www.agbios.com/dbase.php) ° Additional special genetically-transplanted plants, as described in any of the patent applications listed in Table C, including agronomically neutral or advantageous locations A plant containing a transgenic gene. —- ----, plant dilute plant characteristics, nose, spring corn, PV-ZMGT32 (NK603) — Jia can Saixiang US 2007-056056 Maize ' '---- MIR604 insect resistance ΕΡ 1737290 Yulai LY038 13⁄4 More than amines contained US7157281 Corn 3272 Self-treated corn US2006-230473 Corn PV-ZMIR13 (MON863) Insect resistance US2006-095986 Yulai DAS-59122-7 Shark resistance US2006-070139 Yulai TC1507 Insect resistance US2005-039226 Jade to Mon810 —----- Insect Resistance US2004-180373 Jade------- VIP1034 Insect Resistance W003052073 Corn B16 Solid Killing Pillow US2003126634 Jade to GA21 Xisai·Yuxiang US6040497 Yulai~ ~---- GG25 嘉磷窠耐夸 US6040497 玉来GJ11 喜磁寒耐香 US6040497 玉来 FI117 喜瑞塞射令 US6040497 corn GAT-ZM1 固杀簟 resistance WO01/51654 Wheat Event 1 Fusarium resistance CA2561992 (Trichosporin 3-0 - to GAT-OS2 Guticide resistance WO 01/83818 38 200926984 Plants having the above characteristics are not exhaustively listed in Table A.

No. A-1 ------ Target of action or performance factor ~ 1 — Crop phenotype/tolerance Acetyl lactate synthase (ALS) Continued brewing of urea compound, miso ketone ketone three whistle-- ---- A-2 pyridine, pyrimidinyloxy benzoate, benzoquinone-CoA carboxylate (ACCase) aryl decyl phenoxy alkanecarboxylic acid, cyclohexyl A-3~~ Diketohydroxyphenylpyruvate dioxygenase (HPPD) Isomers such as iso-U, such as isoindolinone or isopropoxide, -----trione, such as mesotrione or sulcotrione A-4 sylvestre sylvestre transfer enzyme glufosinate A-5 0-methyl transferase lignin content change A-6 glutamine indoleamine synthase solid grass, dipropylamine fill A-7 —---- J-glycosuccinate lyase (ADSL) IMP and AMP synthesis inhibitor A-8 gland 4 acid-depleted 51 acid synthase adenosine succinate synthesis inhibitor A-9 o-amino benzoate synthase tryptophan Synthetic and metabolic inhibitors A-10 Nitrile 3,5-didentate-4-hydroxybenzonitrile, such as _ bromoxynil and roxinyl A-11 5-enolpyruvyl-3-phosphate Shikimate oxalate synthase (EPSPS) Jiaphosate or sulforaphane A-12 Phosphate or sulforaphane A-13 protoporphyrinogen oxidase (PROTOX) diphenyl ether, cyclic imine, phenyl p 嗤, π ratio bite derivative, salt, oxadiazole oxime A-14 cytochrome Ρ450 such as P450SU1 heterogeneous biomass and herbicides, for example, urinary urea compound A-15 antifungal multi-ribbed AlyAFP plant pathogen A-16 glucose oxidase plant pathogen A-17 ° than B bacteriocin synthesis gene plant pathogen 39 200926984 ❹ No. ' —-------- Now f crop phenotype / tolerance

~A Α-20 Plant antibiotic Α·21 Bl,3-glucanase (antisense) — plant pathogens such as bacterial leaf mold and rice A-22 receptor kinase f, such as bacterial leaf emblem and rice j Pathogens, such as bacterial leaf mold and rice ______________ A-23 has the same effect - ___ -~ raw (S_AR) gene mold and nematode pathogens, pathogens, such as bacterial leaf mold and rice - _# α ·26 glucanase Α-27 double-nuclear plant pathogen

, BYDV and MSMV A-28 envelope protein, forgotten - palm bacillus toxin, photobacterium and pathogenicity = eye m such as bacillus ♦ 1 such as 'slightly like a 'diptera, Α-30 3-hydroxy steroid oxidation The enzyme rice planthopper-31 peroxidase lepidopteran such as the peacock fly locust rice brown fly wind A-32 such as the scorpion scorpion, coleoptera, such as rice weevil, diptera rice brown dragon wind ____ such as mast螟 'Coleoptera, such as rice scorpion, Diptera 丄 ^ rice brown planthopper ___ 'such as 蛀 螟, Coleoptera, A. For example, rice 曱 曱, Diptera, rice for the earth to follow 31_ 虱Lepidoptera, such as indica, mirabilis peptidase inhibitors, such as leucine lepidoptera aminopeptidase inhibitor A-33 lectin 200926984 numbered target or performance element ""'''''~___ Crop phenotype/tolerances such as rice weevil, diptera, - such as rice brown il. A-34 protease inhibitors --- d lepidoptera, such as masts, coleoptera, such as rice weevil, Diptera, rice planthopper such as rice brown planthopper A-35 ribosome-inactivated protein Lepidoptera, such as mast, Coleoptera 'Tf elephant weevil, such as rice weevil, Diptera, rice fly, Rice brown fly A-36 HMG-CoA reductase Lepidoptera, such as scorpion scorpion, coleoptera, such as rice weevil, diptera, rice squirrel, such as rice brown planthopper, A-37, inhibits protein synthesis, acetanilide For example, alachlor, amine, xylenol, a particularly useful gene-transforming plant to be treated according to the present invention, is a plant containing a combination of a morph or a morph, such as a national or regional regulatory agency. In the database (see for example http: //gmoinfojrc.it 5 /gmp_br〇wse.aspx and http : "www.agbios.com/dbase.php) ° 特别 Particularly useful gene transfer plants that can be treated according to the invention For plants listed in Table B under their trade names. 200926984 ❹ Ο Table 实例 Example numbered trademark name ----- Description H7-l strain — Bl Roundup Ready® Beta vulgaris (beet) Β-2 InVigor® Brassica napus (Argentine fennel) ----- Rape gene Renovation: performance of genes that provide tolerance to herbicides; genetically engineered male plants infertility (MS) and fertility restoration (RF) plants, introduced novel hybrid rapeseed breeding; Gene Β-3 Liberty Link® Brassica napus 丄Argentine pods) to glufosinate Β-4 Roundup Ready~~ Rape (mustard) —-— MON89249-2 (GT200) strain Β-5 Clearfield® mustard non-GMO , ima Β -6 OptimumTM GATTM Glycine max L. i Soy) Tolerant to Jia Phossein and ALS Herbicide Round-7 Roundup Ready® Glycine max L. (Soy) MON-04032-6(GTS 40-3-2) Β-8 Roundup RReadv2Yield Glycine max L. (soy) ΜΟΝ-89788-1 (ΜΟΝ89788) Β-9 STS® Glycine max L. Γ soybean) sulfonyl Urea tolerant Β-10 YIELD GARD® Glycine max L. i soybean) Β-1 1 AFD® Gossypium hirsutum L. (Cotton) Plants include, for example, AFD5062LL, AFD5064F, AFD 5065B2F, AFD seeds from several varieties of technology companies, such as Bollgard®, Bollgard II, Roundup Ready, 42 200926984

Examples of numbered trademark names Roundup Ready Flex and LibertyLink® Technologies. B-12 Bollgard II® Gossypium hirsutum L. (Cotton) MON 15985 Line: Cry2(A)bl; CrylA(c) B-13 Bollgard® Gossypium hirsutum L (Cotton) MON531/757/1076 Line: Cry lAc B-14 FiberMax® Gossypium hirsutum L. (Cotton) Improve Fiber Quality B-15 Liberty Link® Gossypium hirsutum L. (Cotton) Tolerance to Graciline B-16 Nucotn 33B Gossypium hirsutum L. (Cotton) Bt-toxin in Delta Pine strain: CrylAc B-17 Nucotn 35B Gossypium hirsutum L. (Cotton) Bt-toxin in Delta Pine strain: CrylAc B-18 Nucotn® Gossypium hirsutum L. (Cotton) Bt-toxin in Delta Pine strain: CrylAc B-19 PhytoGenTM Gossypium hirsutum L. (cotton) covers, for example, Roundup Ready flex, Widestrike variety, B-20 Roundup Ready Flexes Gossypium hirsutum L. (cotton) MON88913 strain 43 200926984 Ο Ο Example number description of the brand name Β-21 Roundup Ready® Gossypium hirsutum L. (Cotton) MON1445/1698 Line Β-2 2 WidestrikeTM Gossypium hirsutum L. (Cotton) Cry IF and Cry lAc Β-23 YIELD GARD® Gossypium hirsutum L. (Cotton) Β-24 Roundup Ready® Medicago sativa (苜蓿) ΜΟΝ-ΟΟΙΟ-8, M0N-00163-7 (J101, J163) strain Β-25 Clearfield® Oryza sativa (m) Non-GMO, tolerant to 曱 咪 Atlantic -26 Atlantic and Superior New Leaf Solanum tuberosum L. ATBT04-6, ATBT04 -27, ATBT04-3 0, ATBT04-31, ATBT04-36, SPBT02-5, SPBT02-7 Β-27 NewLeaf® Solanum tuberosum L. (马钤薯) Includes eg RBMT15-101, SEMT15-02, SEMT15- 15 Β-28 NewLeaf® plus Solanum tuberosum L. Contains, for example: RBMT21-129, RBMT21-350, RBMT22-082 Β-29 Protecta® Solanum tuberosum L. (Potato) Β-30 Russet Burbank NewLeaf ® Solanum tuberosum L. (Potato) Contains for example: BT6, BT10, BT12, BT16, BT17, BT18, BT23 line 44 200926984 No. Trademark name example description B-31 Clearfield® to hollyhock non-GMO, methoxyacetate Tolerant to B-32 Roundup Ready® Triticum aestivum (small麦) MON7 1800 strain B-33 Clearfield® wheat non-GMO, tolerant to dimethoate B-34 Agrisure 3000GT Zea mays L. (Corn) CB/LL/RW/GT: Tolerant to Jia scale Via the GA21 strain, Bt丨1 strain event, (modified synthetic cry3 A gene) favors glufosinate-tolerant B-35 Agrisure CBILL Zea mays L. (Corn) Bt 11 strain and is resistant to glufosinate by GA21 strain B-36 Agrisure CB/LL/RW Zea mays L. (Corn) Bt 11 strain, engineered synthetic cry3A gene, resistant to glyphosate by GA21 strain B-37 Agrisure CB/RW Zea mays L. i corn) Bt-11 strain, CrylAb + MIR604 strain, modified Crv3A B-38 Agrisure GT Zea mays L. (corn) resistant to Jia Phoser B-39 Agrisure GT/CB/LL Zea mays L. (corn) to Jiaxiongsai Tolerance and by GA21 strain, Bt 11 strain favors glufosinate tolerance B-40 Agrisure GT/RW Zea mays L. (Corn) Synthetic Cry3A gene B-41 Agrisure RW Zea mays L (Maize) MIR60 strain, engineered synthetic Cry3A gene B-42 Agrisure® (Family) Zea mays L. (Corn) Bt-ll strain ,CrylAb B-43 BiteGard® Zea mays L. (Corn) crylA(b) Gene 45 200926984 No. Trademark Name Example----- Description B-44 Bt-Xtra® Zea mays L. f玉来) —--- crylAc gene B-45 Clearfield® Zea mays L. (Corn) Non-GMO, Tolerant to Oxypyramid ~ B-46 Herculex I Zea mays L. (Corn) TC1507 strain, Cry IF — ' B-47 Herculex RW Zea mays L. (Corn) DAS-59122-7 strain, Cry34/35Abl B-48 Herculex Xtra Zea mays L. (Corn) TC1507 strain + DAS 59122-7 strain: Cry IF + Cry34/35Abl (Bt X soil 4A : Black, B-49 Herculex Xtra Zea mays L. (Corn) TC1507 Line + DAS 59122-7 Line + NK603 : Cry IF + Cry34/35Abl (Bt Corn Stack) B-50 Herculex® (Family) Zea mays L. ( Jade) Insect Resistance B-51 IMI® Zea mays L. f Jade 耐受 Tolerant to imidazolinone B-52 KnockOut® Zea mays L. (Corn) SYN-EV176-9 Line: crylA(b) Gene B -53 Mavera@ Zea mays L. (Corn) Highly lysine B-54 NatureGard® Zea mays L. (Corn) crylA〇)) Gene B-55 Roundup Ready® Zea mays L. (Corn) GA21 Gene eight lines, NK603 strain B-56 Roundup Ready® 2 Zea mays L. (maize) e.g. NK603 strain B-57 SmartStax Zea mays L. (maize) of the stack from YieldGard VT Triple Pro, Herculex XTRA, 46 200926984

编号 Example number description of brand name B-58 StarLink® Zea mays L. (Corn) Cry9c gene B-59 STS® Zea mays L. (Corn) Tolerant to Dendrobi urea B-60 YIELD GARD® Zea mays L. ( Corn) MON810 strain, CrylAb B-61 YieldGard Plus Zea mays L. (Corn) Cry lAb + Cry3Bbl (Bt corn stack) B-62 YieldGard Rootworm Zea mays L. i jade) MON863 strain, Cry3Bbl B-63 YieldGard RounduD Zea Mays L. (Jade) MON810 strain + Nk603 strain, CrvlAb B-64 YieldGard VT Pro Zea mays L. Γ玉来) MON89034 strain / Cry 1A.105 +Crv B-65 YieldGard VT Rootworm ----- Zea Mays L. (Corn) MON88017 strain/Cry3Bbl B-66 YieldGard VT Triple Zea mays L. (Corn) MON88017 strain/Cry3Bbl + Mon810 B-67 YieldGard VT Triple Pro Zea mays L. (Corn) MON88017 strain/Cry3Bb+MON89034 /Cry 1A.105 + Cry 2Ab2 B-68 YieldMakerTM — ” Zea mays L. (Corn) Includes Roundup Ready 2 Technology, YieldGard VT, YieldGard Corn Bran, YieldGard Rootworm and YieldGard Plus Rice neutral or favorable position on the agronomic plant meters, as listed in Table (c), containing at least includes a gene transfer colonize plant. 47 200926984 糸 糸 CL121, CL141, CFX5 1 Description IMINTA-1, IMINTA-4 LLRICE06, LLRICE62 LLRICE60 PWC16 g in 1 salivary herbicide, imidazole tolerance, by using methyl sulfonate (EMs) ) induced by chemical mutagenesis of acetaminolate synthase (ALS) enzyme. The tolerance of the herbicide to ~~~~-.~ _____ is derived by chemical mutagenesis of the enzyme using sodium azide. _ ^ The herbicide-tolerant rice herbicide is produced by inserting a gene encoding a modified sylvestre sylvestre transferase (PAT) from the soil of Streptomyces hygroscopicus. ' ------------ = The rice that is tolerant to f herbicide herbicides is transferred to the enzyme by Streptomyces hygroscopicus The coding gene of PAT) is inserted. 1 The tolerance of imazamoxone herbicide to imiprazole was initiated by chemical mutagenesis of acetamyl lactate synthase (Als) enzyme using ethyl formate (EMS). °s In a very specific embodiment 'describes a method for the therapeutic or prophylactic control of phytopathogenic fungi and/or microorganisms and/or pests of plants or crops' including the use of ((A) and (8)) or (( The composition of A) and (B) and (〇) is applied to a seed, a plant propagation material, a plant or a fruit of a genetically modified plant, wherein the activated element system expressed by the genetically modified plant is in phase with the product of Table A, B or C. Corresponding. In a very specific embodiment, a method for the therapeutic or prophylactic control of phytopathogenic fungi and/or microorganisms and/or pests of plants or crops is described, including the use of ((A) and (B)) or (A combination of (A) and (B) and (〇) a seed, plant propagation material, plant or fruit of a genetically modified plant, wherein the activated element expressed by the genetically modified plant is associated with any of Tables A, B or C 48 10 200926984 Composition of the inventive composition. Preferred carrier, interface ===... can be bile organisms, solvents, and thus acceptable. Carriers can also be organic compounds,丄4:;==: organic or no carrier is preferably inert and at least agricultural疋'. Knife Ο 10 15 ❹ 20 Solid or liquid. Suitable solid carriers are as follows: For example 'ammonium salt f natural rock powder, such as kaolin, clay, talc, and its derivatives m, activated clay, montmorillonite or earthworm Algae, and synthetic rock = 歹j such as 冋度刀刀之石石, 氧化铭和石夕酸,油蜡, solid fertilizer, Lai's preferred butanol, organic solvent, mineral oil and vegetable oil * palatable granules Solid carriers for use include, for example, ground and graded natural stone such as calcite, marble, pumice, sepiolite dolomite, and inorganic and organic, granules and particles of organic materials such as paper, wood chips, Coconut shell, corn shaft and tobacco stalk. Liquefied gas diluent or carrier refers to such a gas at normal temperature and pressure, such as aerosol propellant such as from base smoke and butyl, hexazepine, nitrogen And carbon dioxide. Adhesives such as slow methyl cellulose, natural and synthetic powders, estradiol or _ (tetra) compounds such as ala, poly squaring and polyvinyl acetate s Brain and (4) lipid and 49 200926984 Additional additives may be mineral or vegetable oils and signs

10 Suitable extenders are 'for example, water, polar and non-polar organic compounds' such as from aromatic and non-aromatic hydrocarbons (for example, woven ketones 'alkyl naphthalene' benzene), alcohols and many more Alcohols (if appropriate, ς = = substitution, E-bonding and/or S-specification) 'classes (eg, propyl, cyclohexyl), '=: (including fats and oils) and (poly) Ethers 'unsubstituted and substituted amines, =, intrinsic amines (eg, fluorenyl-alkylpyrrolidone) and lactones, terpenoids (eg, disulfoxide). _If the extender used is water, it is also possible to use, for example, an organic agent as an auxiliary solvent. In essence, a suitable liquid solvent is an aromatic system, a scorpion, a thiophene or a sulphuric acid, a chlorinated aromatic or a chlorinated smog, a chlorobenzene, a vinyl chloride or a methylene chloride. , aliphatic hydrocarbons such as 15

Or paraffin waxes such as petroleum distillates, mineral oils and vegetable oils, alcohols such as or ethers of ethylene glycol and the like, and esters, ketone groups such as propyl ketone, chloroethyl ketone, decyl isobutyl ketone or cyclohexyl Ketones, strong polar solvents such as diterpenoids, and water. — 20 Synthetic phospholipids. Modified as needed. Human compositions of the invention may also comprise additional compounds. In particular, the group σ may additionally comprise a surfactant. The surfactant may be an emulsifier, dispersant or wetting agent in ionic or nonionic form or a mixture of such surfactants, such as polyacrylates, lignosulfonates, benzene = 3⁄43⁄4 salts. a polycondensate of a class or a naphthalene sulfonate, an ethylene oxide and a fatty alcohol or a fatty acid or a steroid, a substituted phenol (particularly an alkyl phenol or an aryl hydrazine), a salt of a succinic succinate a class of taurine derivatives (especially taurine 50 200926984 burnt vinegar), polyoxyethyl alcohols or ketones, fatty acid vinegars of polyalcohols and the functions of sulphuric acid, tartaric acid and acid Derivatives of the inventive compounds, such as aryl aryl polyethylene glycol oxime, sulphur sulphur, sucrose vinegar, aryl sulfonate, protein hydrolysate, wood t-sulfite waste liquid. When g/tongue compounds and/or inert carriers are not water soluble, it is generally necessary to have at least one surfactant present. Preferably, the surfactant dose may comprise from 5% to 40% by weight of the composition. Suitable emulsifiers and/or foam formers are, for example, nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, suitable dispersing agents such as, for example, nonionic and/or Ionic materials, for example from alcohol-POE and/or -POP ethers, acid and/or pop p〇E esters, alkylaryl groups and/or POP p-consin, fats and/or p〇pp〇 E adducts 'POE and/or pop polyol derivatives, p〇E and/or pop/sorbitol or sugar adducts, alkyl or aryl sulfates, alkyl or aryl sulfonates and alkanes A aryl or aryl phosphate or an associated p0 ether adduct. Further, suitable oligomers or polymers, for example, oligomers based solely on ethylene monomers, acrylic acid, E fluorene and/or p oximes or, for example, in combination with (poly)alcohols or (poly)amines Object or polymer. It is also possible to use lignin and its sulfonic acid derivative, simple and modified cellulose, aromatic and/or aliphatic sulfonic acid and their addition to formaldehyde. Suitable as a dispersing agent are, for example, lignin sulfite waste liquid and methyl cellulose. Colorants such as inorganic dyes such as iron oxide, dioxins and Prussian blue, and organic pigments such as alizarin dyes, azo dyes and metal titanium cyanine dyes, and trace elements such as iron and manganese may also be used. Salts of boron, copper, cobalt, molybdenum and zinc. 51 200926984 'Alternative compounds' such as protective colloids, adhesives, copper extenders, thixotropic agents, stabilizers, metal masking agents may also be included as needed. More generally, the active compound can be combined with any solid or liquid additive that is compatible with conventional formulation techniques. Generally, the composition of the present invention may contain from 5 to 99% by weight of the active composition, preferably from 1 to 70% by weight, most preferably from 10 to 50% by weight. The compositions or compositions of the present invention may be used in the form of their formulations or as a form of use prepared therefrom, such as sprays, capsule suspensions, cold sprays, thermal sprays, capsule granules, fine granules. , seed treatment aqueous suspension, directly usable solution, powder, emulsion, water-based emulsion, oil-based emulsion, microparticle, oil-dispersible powder, oil suspension, oil-soluble granule, foaming agent, paste, seed coating agent , aqueous suspensions, suspoemulsions, solutions, suspensions, soluble powders, granules, water-soluble granules, seed-treated water-soluble powders, wettable powders, natural or synthetic substances impregnated with active compounds, microcapsules for seed polymerization Substance or wrap and ULV-cold or hot mist formulation (pressurized), gas generating agent, drug swab, dry seed powder, seed treatment solution, ultra low volume (Ulv) liquid, ultra low volume (ULV) A suspending agent, a water-dispersible granule or a tablet, a slurry-treated dispersible powder. These formulations can be used in a known manner by the active compound or active compound with customary additives, such as conventional extenders and solvents or diluents, emulsifiers, dispersants and/or binding or fixing agents, wetting agents, water repellents, If appropriate, drier and UV stabilizers, colorants, colorants, defoamers, preservatives, secondary thickeners, adhesives, gibberellin and water, and other processing aids other than 200926984 The composition is mixed. These compositions include not only compositions which can be immediately applied to the plants or seeds to be treated by suitable means (e.g., spray or dusting means), but also concentrated commercial compositions which must be diluted prior to administration of the crop.

❹ 10 15 ❹ 20 Control of phytopathogenic fungi and/or micro-organisms and/or pests of plants that have been infested by post-emergence by treating the soil and the upper part of the plant with crop protection agents. Due to concerns about possible conflicts with crop protection agents on the soil and human and animal health, efforts are needed to reduce the amount of active compounds used. The active compound compositions of the present invention can be used in their commercial formulations and in the form of use prepared from such formulations, in admixture with other active compounds, such as insecticides, attractants, sterilants, bactericides, mites. Agents, nematicides, fungicides, growth regulators, herbicides, safeners, fertilizers or chemical messages. The treatment of the plant and plant parts with the active compound composition of the present invention may be carried out directly or by treatment in its environment, habitat or storage area, for example by using water washing (immersion), drip irrigation, spraying, Evaporation, = chemical, spreading, dusting, foam formation, diffusion and treatment as a dry seed =, seed treatment solution, seed treatment water-soluble (four), water treatment, or by covering, in the case of reproduction (four), In particular, the case can be carried out by dry treatment, slurry treatment, liquid treatment or one or more layers. Furthermore, it is possible to administer/degenerate the δ substance by an ultra-low amount method, or to inject the active compound preparation or the active compound itself into the soil 攘. 53 200926984 The application rate of the composition, for example, depending on the type of use, the type of crop, the particular active compound in the composition, the type of plant propagation material, if appropriate, but in the composition the active compound is in an amount effective to provide The strengthening effect of owing (such as disease or pest control) can be determined by experimentation. The treatment method of the present invention also provides for the simultaneous, separate, and sequential use of the compound (A). The dosage/administration amount of the active compound which is usually used in the treatment method of the present invention is general and advantageous. - for leaf treatment: from 0.1 to 1 Torr, 〇〇〇g/ha, preferably from 1 〇 to 1 〇〇〇g/ha', more preferably from 50 to 3 〇〇g/ha of compound (B ); from 〇.1 to 10,000 g/ha, preferably from 1 〇 to 1 〇〇〇g/ha, more preferably from 5 〇 to 3 〇 such as /^ of the compound (C), impregnation or drip irrigation In the case of administration, the dose may even be reduced, especially when using inert materials such as rockwool or perlite; • for seed treatment: from 2 to 2 grams per 1 kg of seed, preferably per 100 Kilograms of seeds from 3 to 150 grams of compound (A), from 1 to 200 grams per 1 kilogram of seed, preferably from 3 to 15 grams per 100 kilograms of seed (B) 'per 1 kilogram The seed is from 2 to 2 grams, preferably from 3 to 15 grams per 1 kilogram of seed (〇; for soil treatment. From 〇1 to 1〇, 〇〇〇g/ha, Preferably, the compound (A) from 5 to 10, 11/11 &, from 0.1 to 10,000 g/ha, preferably from 1 to 5,000 g/ha of the compound (B), from hydrazine to (7)^(9) g/ Ha, preferably from 1 to 5,000 g/ha of compound (c). The dosage referred to herein is as the present invention Examples of the method. Those skilled in the art should understand how to adjust the amount of the formulation, especially according to the nature of the plant or crop as desired. / The composition of the invention can be used against phytopathogenic fungi and/or microorganisms And/or protecting the plant within a specific time frame after treatment of the pest. The time frame in which the protective effect is effective is generally extended to one to 28 days, preferably one to 14 days, or in the treatment of plant propagation material after treatment of the plant with the composition. After the last 200 days. The method of the invention can also be used to treat reproductive material such as tubers, roots 10 15 ❹ 20 stems, as well as seeds, seedlings or seedlings and planting or planting. This treatment can also be used to treat roots. The treatment method of the invention can also be applied to the above parts of the plant ground, for example, the trunk, stem or branches, leaves, flowers and fruits of the plants. The other aspect of the invention is to protect the natural source of plants or animals taken from the natural life cycle. A method of treating a substance or a processed form thereof, the method comprising administering a natural substance of the plant or animal origin or a processed form thereof A combination of an effective amount of the compound (A), the compound (B) and the compound (C). A preferred embodiment is a method for protecting a natural substance derived from a plant of natural life or a processed form thereof, The method comprises administering a composition of the natural substance derived from the source or a treated form thereof to a synergistically effective amount of the composition of the compound (A), the compound (B) and the compound (C). Another preferred embodiment In order to protect the fruit from the natural life cycle, preferably a pome fruit, a nut, a berry, a citrus fruit or a treatment thereof, the method comprises administering a natural substance derived from the plant or treating the complex form. Compound (A), Compound (B) and Compound (c) 0 〇 55 200926984 The present invention includes a process in which the seed system is simultaneously treated with the compound (4), the compound (8) and the compound (c). It further includes a method in which the seed is compounded. 4 (A), compound (8), and compound (c) are separately treated. The present invention also encompasses the simultaneous treatment of the compound (A), the compound (8) and the compound 5 (the seed treated with hydrazine. The present invention also includes the separation of the compound (4), the compound (8) and the compound (the seed treated with Q. For the latter seed, the active ingredient can be divided The layers are applied. These layers may be separated by additional or no active ingredient layers as needed. Eucalyptus plant or composition ❹m combined with silk _ sub. By 10 (10) and / New Zealand disease secrets and / money Most of the damage caused by biological and domain money on cultivars occurs during storage or after sowing on the ground and during and after germination of the plants. This stage is particularly important because the roots and shoots of growing plants are particularly sensitive. And even a small amount of damage may cause the whole plant to wither. Therefore, it is of great interest to protect the seed 15 and the plant in the germination by using appropriate agents. By controlling the plant seeds to control pests and/or phytopathogenic fungi and / / Microorganisms and/or pests are known to have a long time and are the goal of continuous improvement. However, there are many problems in the treatment of seeds that cannot be satisfactorily resolved. , Chad develops methods for the protection of seeds and plants in germination, so that no additional plant protection agents need to be applied after sowing 20 species or plants. In addition, the amount of active substances that are optimally applied is not found in the plants themselves. The application of the active compound under injury 'so that the seed and the germinated plant are protected as much as possible against the infection of pests and/or phytopathogenic fungi and/or microorganisms and/or pests. In particular, the method of treating seeds should also consider genes. Transplanting plant 56 200926984 Its own fungicidal and insecticidal properties, in order to achieve the most suitable seed and germination plant protection with the lowest amount of plant protection agent. The present invention therefore relates to the protection of seeds and germinated plants in particular. A method of preventing infection by pests and/or phytopathogenic fungi and/or microorganisms and/or pests, wherein the seed is treated with the composition/composition of the invention. Furthermore, the invention also relates to the composition/composition of the invention for treating seeds Protection of seeds and plants in germination from the use of pests and/or phytopathogenic fungi and/or microorganisms and/or pests. The invention relates to the treatment of the compositions/compositions of the invention for the protection of pests and/or phytopathogenic fungi and/or microorganisms and/or pests. One of the advantages of the invention is that the composition according to the invention /Special system characteristics of the composition, which are treated with these compositions/compositions to protect not only the pests themselves and/or phytopathogenic fungi and/or microorganisms and/or pests, but also plant plants after germination. It is possible to dispense with the direct treatment of the plant at or after sowing. Another advantage is that it synergistically increases the fungicidal and insecticidal activity of the compositions/compositions of the invention compared to the individual active compounds, extending over one The total activity of the individual active compounds administered. This method makes it possible to administer the optimum amount of active compound to be applied. The mixture of the invention can also be used for (in particular) gene transfer of seed, whereby the plant strain from which the seed grows can be expressed Anti-fungal and phytopathogenic fungi and/or proteins of microorganisms and/or pests' are also considered to be advantageous. By treating the seed with a specific agent, 'special pests and/or phytopathogenic fungi and/or microorganisms and/or pests can be affected by the expression of, for example, insecticidal proteins. 57 200926984 f Γ ί Even more shocking (four), the hair (four) agent produced synergistic activity to increase ', and another increase the effectiveness of protection against pest infection. ^Invention_ as already described, suitable for protecting all types of plants

10 15

20 # Θ #子, which can be used in agriculture, greenhouses, forestry, furrow treatment, gardens or vineyards. In particular, this is related to alfalfa - black wheat, millet, oats, rice), corn, cotton, soybeans: horses, 'f bells, sunflowers, beans, coffee, beets (such as sugar beets, Mang sweets) Use sweet rice), peanuts, mustard, rapeseed, sweet millet, olive, coconut, cocoa, sugar cane or terminal grass seeds. The compositions/compositions of the present invention are also suitable for treating seeds of turf, grass and ornamental plants such as fruit plants and vegetables (such as Fan #, gherkin, onion and lettuce). Of particular importance are the seeds of wheat, barley, rye, triticale, millet, oats, corn, rice, soybeans, cotton, mustard, and canola. As already described, it is of particular importance to treat gene-transferred seeds with the compositions/parsates of the invention. This relates to seeds generally containing at least one heterologous gene controlling a plant having a specific insecticidal property. The heterologous gene in the gene-transferred seed can be derived from microorganisms such as bacilli (Wanyan (10)), Rhizobium (Canru), Pseudomonas (10) (10), Serratia (10), Trichoderma (JWch such as mfl), Corynebacterium (10) er), arbuscular bacteria (G/omws) or Gliocladium. The invention is particularly suitable for the treatment of heterologous genes comprising at least one genus of the genus Bacillus and having gene-transgenic seeds resistant to European corn borer and/or western corn rootworm. Particularly preferred of this heterologous gene is derived from Suribacter. ~ In the context of the present invention, the composition/composition of the present invention is administered alone or in a formulation of the combination of 2009 2009. Preferably, the seed is treated in a stable state such that no damage occurs during the treatment. In general, the treatment of the seed can be carried out at any time during the harvest and sowing. Usually the seed is isolated from the plant and has no spikes, husks, branches, inches, hairs, and fruits. The seeds used for the meat are harvested, purified and dried to a water content of less than 15% by weight/weight. In addition, seeds which have been treated with water after drying and then dried again can also be used. In the treatment of seeds, general care is required, and the combined compositions/compositions and additional additives of the present invention which are applied to the seeds are selected so that the seeds are not germinated and the grown plants are not damaged. Please note that all of the above active compounds may exhibit phytotoxic effects when administered in specific amounts. The compositions/compositions of the invention can be applied directly (without additional compounds and without dilution). Generally preferred compositions/compositions are applied to the seed in a suitable formulation. Suitable formulations and methods for seed treatment are known to those skilled in the art and are described, for example, in the following documents: us 4,272,417 A, US 4,245,432 A, US 4,808,43 GA, US ❹ 5,876,739 A, US 2003/0176428 A WO 2002/080675 A, WO 2002/028186 A2. The active compound composition or composition which can be used according to the invention can be converted into conventional soaking formulations, such as solutions, emulsions, suspensions, powders, soaking agents, syrups or other seed coatings, and ULV formulations. . These formulations are known in a known manner by the active compound or active compound composition with conventional additives such as conventional extenders and solvents or diluents, colorants, wetting agents, dispersants, emulsifiers, defoaming agents. Agent, 59 200926984 Preservatives, secondary thickeners, adhesives, Gibberellium and, if necessary, water mixed. Suitable color formers which may be present in the soaking formulations of the present invention include those conventionally used for this purpose. Both water-insoluble or water-soluble dyes can be used. Examples which may be mentioned include the names of rhodamine B, C.I. red pigment 112 and C.I. red solvent 1. G 10 15 适合 Suitable humectants which may be present in the soaking formulations of the present invention include all materials which promote wetting and formulation for active agrochemicals. Preferably, an alkylnaphthalenesulfonate such as diisopropyl or diisobutylnaphthalenesulfonate can be used. Suitable dispersing agents and/or emulsifiers which may be present in the soaking formulations of the present invention include all nonionic, anionic and cationic dispersing agents customary for use in the formulation of active agrochemical materials as described above. Suitable antifoaming agents which may be present in the soaking formulations of the present invention include suds suppressing materials which are customary for use in active agrochemical formulations. It is preferred to use an antifoaming agent and magnesium stearate. Suitable preservatives which may be present in the soaking formulations of the present invention include those which are useful in agrochemical compositions for this purpose. There may be mentioned chlorophenol and benzyl alcohol hemiformal. It is a suitable secondary thickening in the soaking formulation of the present invention, which is a cellulose derivative, an acrylic derivative clay and a highly dispersed stone.物-仙-), 修, may be present in the soaking formulation of the present invention. Comparing agents including household 隹 can be mentioned as polyethyl hydrazine 20 200926984 phenol, polyvinyl acetate, polyvinyl alcohol and hydroxyethyl cellulose (tyl〇se). 5 ❹ 10 15 ❹ 20 Suitable gibberellins which may be present in the soaking formulation of the invention include, preferably gibberellin A1, A3 (=gibberellic acid), A4 and A7, especially gibberellin A3 (=gibberellic acid). The gibberellin of formula (II), the name of gibberellin can be found in the following references (cf. r. Wegler "Chemie der Pflanzenschutz-and Schadlingsbekampfungsmittel", Volume 2, Springer Verlag, Berlin-Heidelberg-New York , 1970, pp. 401-412) Suitable mixing equipment (by adding water) for treating seeds according to the present invention using soaking formulations or preparations prepared therefrom, includes all of the mixing equipment commonly used in the secondary. Specific procedures for seed soaking include placing the seed in a mixer, adding the amount of the desired soaking formulation directly or by pre-dilution with water, and mixing until the formulation is evenly distributed over the seed. Drying is then carried out as needed. In the case of material protection, the materials of the present invention can be used to protect technical materials against unwanted fungal and/or microbial infections and damage. The technical substance 'should be understood' is in the context of the present invention that it has been prepared for engineering. For example, the technical substance is protected by the active substance of the present invention against microbial changes, which are adhesives, glues, paper and cardboard, Fabrics, felts, leather, wood, lacquers and plastics, cooling lubricants and other substances that can be damaged or destroyed by microbes. The nature of the material to be protected can also be adversely affected by the production of parts of the plant, such as cooling cycles, cooling and heating systems, air conditioning and ventilation. In the present invention, the technical material preferably mentioned is adhesive 61 200926984, glue, paper and cardboard, ancient changer liquid, especially wood, wood, paint, cooling lubricant and heat exchange The bismuth composition can prevent, for example, spoilage, fading, discoloration or mildew, and is not conducive to protecting stored articles against fungi and deficiencies: According to the present invention, the term "storage article" is intended to be a plant or animal source material. And its handling ❹ 10 15 ❹ 20 Store items, such as plants; protection is desirable. Fruits of plant origin or parts thereof, such as shoots, leaves, tubers, seeds, stems, may be in their fresh-harvested or processed form, such as pre-defined or baked to protect. Also falling in the storage tower and the grid is (4) fine-grained wood, electric storage items have raw hides, ": wool: with: wooden items. The origin of the animal is left untouched by the mold. It is better to "storage." Oral U solution refers to the natural plant-derived substance f and its treated fruit, which has been treated in the form of pome fruit, nuts, citrus fruits and their treated forms. In the preferred embodiment, "storage items" should know Μ:. The money-killing composition or group secret of this (4) can also be used against fungal diseases that grow on wood or in wood. The term “wood” refers to all types of tree tops and all types of wood, twist wood, sheet wood and plywood. The method of treating wood according to the present invention consists essentially of contacting one or more compounds of the invention 62 200926984 or a composition of the invention; this includes, for example, direct coating, spraying, dipping, injecting or any other suitable method. Among the diseases of plants or crops which can be controlled by the method of the present invention, there may be mentioned: powdery mildew such as: for example, Blumeria disease caused by Blumeria graminis; Ο 10 15 Ο 20 For example, Podosphaera disease caused by P〇d〇Sphaeraleucotricha; for example, monofilament single capsule caused by Sphaerotheca fuliginea Sphaerotheca disease; for example, Uncinula disease caused by Uncinula necator; Phytopathogenic bacteria such as: for example, the bacterium (Gymnosporangium sabinae) caused by the bacterium (Gymnosporangium sabinae) Gymnosporangium); for example, Hemileia caused by coffee | Hemileia vastatrix; for example caused by Phakopsora pachyrhizi and Phakopsora meibomiae Phakopsora disease; for example, Puccinia disease caused by Puccinia recondita; for example, by Phytophthora 63 caused by Uromyces appendiculatus 200926984 Uromyces disease; Oomycete disease, for example: . For example, Bremia disease caused by Bremia lactucae; 5 For example, a downy mildew (per0n0Sp0ra) disease caused by a bowl of Peronospora pisi or p brassicae; for example, a Phytophthora disease caused by Phytophthora infestans; ® For example, Plasmopara disease caused by Plasm〇para viticola; for example, a fake cream emblem caused by Pseudoperonospora humuli or Pseudoperonospora cubensis ( Pseudoperonospora); for example, Pythium disease caused by Pythium ultimum; leaf spot and blight, such as: © for example, chain caused by Alternaria solani Alternaria disease; for example, Cercospora disease caused by Cercospora beticola; for example, Cladosporium fulvum Cladiosporum disease caused by Cladiosporium cucumerinum; for example, Cochliobolus disease caused by Cochliobolus sativus; 64 200926984 [Asexual spore form: inner snail Drechslera, syn: Helminthosporium; for example, Colletotrichum disease caused by Colletotrichum lindemuthanium; 5 For example, Cycloconium oleaginum Cycloconium disease caused by diarrhea; for example, Diaporthe caused by Diaporthe citri; eg, the sac cavity caused by Elsinoefawcettii Ίο菌(Elsinoe) disease; for example, Gloeosporium disease caused by Gloeosporium laeticolor; 'Glomerella caused by, for example, Glomerella cingulata Disease; 15 for example, Guignardia disease caused by Guignardia bidwelli; Leptosphaeria caused by Leptosphaeria maculans; for example, Mycosphaerella caused by Mycosphaerella fijiensis; for example, Phaeosphaeria Phaeosphaeria caused by nodorum; for example, Pyrenophora disease caused by Pyrenophora teres; 65 200926984 For example, by Ramularia collo-cygni Caused by Ramularia disease; for example, Rhynchosporium disease caused by Rhynchosporium secalis; 5 for example caused by Septoria apii Septoria disease; for example, Typhula disease caused by Typhula incarnata; for example, a black spot caused by Venturia inaequalis (Venturia) disease; root and stem diseases, such as: for example, Corticium disease caused by Corticium graminearum; Fusarium disease caused by Fusarium oxysporum; 15 For example, Gaeumannomyces caused by Gaeumannomyces graminis; for example, caused by Rhizoctonia solani Rhizoctonia disease; for example, Oculimacula (Tapesia) disease caused by Oculimacula Tapesia acuformis; for example, roots caused by Thielaviopsis basicola Thielaviopsis disease; ear and inflorescence (including ear of corn) diseases, for example: 66 200926984 For example, Alternaria disease caused by Alternaria spp.; for example, by Aspergillus Aspergillus caused by flavus; 5 for example, Cladosporium caused by Cladosporium spp; for example, ergot caused by Claviceps purpurea (Clavicep) disease; ® such as Fusarium disease caused by Fusarium culmorum; for example by corn Gibberella disease caused by mildew (Gibberella zeae); for example, Monographella disease caused by Monographella nivalis; 15 smut and smut, for example: by corn © Sphacelotiheca (Sphacelotiheca) caused by Sphacelotheca reiliana; for example, Tilletia disease caused by Tilletia caries; 20 Urocystis disease caused by Urocystis occulta; for example, Ustilago disease caused by Ustilago nuda; fruit rot and mildew disease, for example : 67 200926984 For example, Aspergillus disease caused by Aspergillus flavus; for example, Botrytis disease caused by Botrytis cinerea; 5 for example by expanding the green emblem ( Penicillium disease caused by Penicillium expansum; for example, Sclerotinia disease caused by Sclerotiniasclerotiorum; ❹ for example by black Verticilium alboatrum caused by Verticilium disease; seed- and soil-borne decay, mold, wither, rot, and wet and cold rot diseases, such as: for example, Alternaria brassicicola Caused by Alternaria-Arten disease; 15 For example, Aphanomyces-Arten disease caused by Aphanomyces euteiches; ❹ For example, shell II caused by A. sclerotium Ascochyta-Arten disease, for example, Aspergillus-Arten caused by Aspergillus flavus; for example, Cladosporium caused by Cladosporium herbarum -Arten ); for example, Cochliobolus-Arten caused by Cochliobolus sativus; 68 200926984 [Asexual spore form: Drechslera, flat umbilical cord Bipolaris syn: Helminthosporium]. For example, Colletotrichum-Arten caused by Colletotrichum coccodes; 5 cases Fusarium caused by Fusarium culmorum; for example, Gibberella caused by Gibberella zeae; ®, for example, by Macrophomina phaseolin The resulting genus Macrophomina-Arten; for example, Monographella-Arten caused by Monographella nivalis; for example, the blue caused by Penicillium expansum Penicillium-Arten; 15 For example, Phoma-Arten caused by Phoma lingam; ®, for example, the phimosis emblem caused by Phomopsis sojae Phomopsis-Arten; for example, Phytophthora Arten caused by Phytophthora cactorum; for example, Pyrenophora-Arten caused by Pyrenophora graminea For example; Pyricularia-Arten caused by Pyricularia oryzae; 69 200926984, for example, caused by Pythium ultimum Pythium-Arten; For example, Rhizoctonia-Arten caused by Rhizoctonia solani; 5 For example, Rhizopus caused by Rhizopus oryzae (Rhizopus- Arten); for example, Sclerotium-Arten made from Sclerotium rolfsii; ®, for example, the genus of the genus Septoria-made by Septoria nodorum (Septoria- Arten); for example, Typhula-Arten formed by Typhula incarnata; for example, Verticillium-Arten caused by Verticillium dahliae 15 ulcer disease, arbuscular disease and blight disease, such as, for example, Nectria disease caused by Nectria galligena; Fusarium wilt, for example: Sclerotinia sclerotiorum (Monilinialaxa) caused by 2 〇 (Monilinia) disease; atherectomy or leaf deficiencies, including flower and fruit deformation, such as for example caused by Taphrina deformans (Taphrina) Disease; degradation of woody plants Diseases, for example: 70 200926984 For example, Phaemoniella clamydospora, Phaeoacremonium aleophilum and Fomitiporia mediterranea and Isaac (Esca) Diseases; 5 flower and seed diseases, such as: Botrytis disease caused by Botrytis cinerea; stem disease, for example: silk core caused by Rhizoctonia solani Rhizoctonia disease; for example, Helminthosporium caused by Helminthosporium solani; diseases caused by bacteria, such as Xanthomonas, for example Xanthomonas campestris pv. oryzae; Pseudomonas, such as Pseudomonas syringae ργ. lachrymans » Erwinia, such as Erwinia amylovora Erwinia amylovora) ° 20 The compounds of the present invention are preferably used to control the following soybean diseases: leaves, upper stems, pods And fungal diseases of seeds, such as: leaf spot disease [Alternaria spec, atrans tenuissima], anaesthetic disease [Red leaf spurs of the genus Bacillus genus 200926984 (Colletotrichum gloeosporoides Dematium var. truncatum) ' Brown spot disease [Sept〇ria glycines], Cercospora leaf spot and Fusarium wilt [Cercospora kikuchii], Bean leaf spot disease [井徽属二Choanephora infundibulifera trispora 5 (syn·)], Phytophthora leaf spot disease (Dactuliophora glycines), frost plague [Northeastern double bacterium (per〇n〇Sp〇ra manshurica) )], bridged wilt disease [Drechslera glycini], spot disease [Cercospora sojina], bean leaf spot disease [Leptosphaerulina trifolii], leaf ίο Point leaf spot disease [Phyllosticta sojaecola], powdery mildew [Microsphaera diffusa], Phytophthora leaf spot [Pyrenochaeta glycines], silk nucleus Bacteria roots, leaves Net wilt disease [Rhizoctonia solani], recorded disease [Phakopsora pachyrhizi, Phakopsora meibomiae], black star disease [soybean black pox pathogen] (Sphaceloma glycines)], Solanum tuberculosis leaf blight [Stemphylium botryosum], spot disease [Corynespora cassiicola] fungal diseases of the roots and lower stems, for example: 20 black Root rot [Calonectria crotalariae], charcoal rot [Macrophomina phaseolina], Fusarium blight or withering, root rot and pod and neck rot [(Fusarium oxysporum) , Straight "Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti, dark silk spore root 72 200926984 rot [Mycoleptodiscus terrestris], new red shell Bacterial disease [Neocosmospora vasinfecta], pod blight and stem blight [Diaporthe phaseolorum], stem ulcer disease [Diaporthe phaseolorum var. caulivora] )] Phytophthora megasperma, stalk brown rot [Phialophora gregata, Pythium root rot I; Pythium aphanidermatum, abnormal female rot Pythium irregulare, Pythium debaryanum, Pythium myriotylum, pythium ultimum, root rot, stem rot and wet rot Rhizoctonia solani)], sclerotium stalk disease [Sclerotinia sclerotiorum], chalk disease [Sclerotinia rolfsii], Rhizopus oryzae [Thielaviopsisbasicola] The active compound compositions/compositions of the invention may also be used in the preparation of compositions for the treatment of fungal or human fungal diseases, such as fungal diseases, skin diseases, rickets and candidiasis or by sputum A disease caused by a genus such as a smog. The active compound composition/composition of the invention combines good plant tolerance with favorable toxicity to warm-blooded animals and is completely environmentally tolerant, and is suitable for protecting plants and plant organs, increasing harvest rate, and improving harvests. Quality and control of animal pests, especially in agriculture, horticulture, animal husbandry, forestry, gardens and leisure facilities, protection of stocks and materials, hygiene, insects, spiders, worms, nematodes and mollusks. It is preferably used as a plant protection agent at 73 200926984. It is generally resistant to all or some developmental stages of anti-sensitive and resistant species. The above pests include: • From Anoplura (Phthiraptera), such as Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., hair (Trichodectes spp.). From Arachnida, such as Acarus siro, Aceria sheldoni, Aculops spp., Aculus spp., flower bud (Amblyomma spp.), Argas i〇spp., Boophilus spp., Brevipalpus spp., Dermanyssus gallinae, Eotetranychus spp, leaves Epitrimems pyri, Eutetranychus spp., Eriophyes spp., Hemitarsonemus spp., Hyalomma spp., Ixodes spp. ), Latrodectus mactans, Metatetranychus spp., Oligonychus ® spp., Ornithodoros spp., Panonychus spp., Phyllocoptruta Oleivora), Polyphagotarsonemus latus, Psoroptes spp·, Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio Maurus), Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp .), tomato sloping tumor monument (Vasates lycopersici). From the Bivalva, such as Dreissena spp. 74 200926984 From the order of the Chilopoda, for example, Geophilus spp., Scutigera spp. From Coleoptera, such as Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp., Amphimallon solstitialis, furniture thieves ( Anobium punctatum), Anoplophora spp., Anthonomus SPP., Anthrenus spp., Apogonia spp., micro

Q. Atomaria spp., Attagenus spp., Bean ίο (Bruchidius obtectus), Bmchus spp., Ceuthorrynchus spp., Cleonus mendicus, 叩Conoderus spp., Cosmopolites spp., Costelytra spp., Curculio spp., Cryptorhynchus lapathi, Dermestes spp., Diabrotica Spp.), Epilachna spp., Faustinus cubae, Gibbium psylloides, Heteronychus arator, ® Hylamorpha elegans, North American Hylotrupes bajulus, Hypera postica, Hypothenemus spp., Lachnosterna consanguinea, Leptinotarsa decemlineata, Lisorhoptrus Oryzophilus), Lixus spp., Lyctus spp., Meligethes aeneus, Melolontha melolontha, Migdolus spp., Monochamus spp .), symbolic (Naupactus xa rUhographus), yellow spider mites (Niptus 75 200926984 5 ❿ 10 15 ❹ 20 hololeucus), rhinoceros rhinoceros, Oryzaephilus surinamensis, black worm main elephant trunk: & (Otiorrhynchus sulcatus), small Blue-eyed tortoise (Oxycetonia jucunda), Phaedon cochleariae, Phyllophaga spp., Popillia japonica, Premnotrypes spp., Psylliodes chrysocephala, spider Tin (Ptinus spp.), Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sphenophorus spp., Sternechus spp., Symphyletes spp .), Tenebrio molitor, Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrus spp ·). From Collembola: For example, Onychiurus armatus ° comes from the order of Dermaptera: for example, Forficula auricularia. From Diplopoda: for example, Blanciulus guttulatus. From Diptera, such as Aedes spp., Anopheles spp., Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata , Chrysomyia spp., Cochliomyia spp., Cordylobia anthropophaga, Culex spp., Cuterebraspp., Dacusoleae , Dermatobia hominis, Drosophila spp., toilet flies (Fannia 76 200926984 spp.), stomach flies (Gastrophilus spp.), species (Hylemyia spp.), insect flies (Hyppobosca spp.) , Hypoderma spp., Liriomyza spp., Lucilia spp., Musca spp., Nezara spp., Oestrus spp. , Sweden's Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Stomoxys spp., 4t (Tabanus spp.), Tianni spp (Tannia spp· ), Tupula paludosa, Wohlfahrtia spp.

Qi comes from gastropoda, such as Arion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., vertebral snail Galba spp.), Lymnaea spp., Oncomelania spp., Succinea spp. From intestinal helminthes, such as Ancylostoma duodenale, Ancylostoma 15 ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides , Ascaris spp., Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., trematode Clonorchis spp·), Cooperaria 2〇spp·, Dicrocoelium spp, Dictyocaulus filaria, Diphyllobothrium latum, Medina Dracunculus medinensis), Echinococcus granulosus, Echinococcus multilocularis, Enterobius vermicularis, trematode (Faciola 77 200926984 spp.), Haemonchus spp, blind worm (Heterakis spp.), Hymenolepis nana, Hyostrongulus. spp., Loa Loa, Nematodirus spp., Esophageal ostia Oesophagostomum spp., Opisthorchis 5 spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen Spp.), Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp., Taenia saginata, Taenia solium , Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp. Whipworm (1[1^11111^仕1〇11111^), Ban's filarial (\^11.116 to 1^匕&11(;1:0 line 〇. 15 In addition, protozoa can be controlled, such as Eimeria. From Heteroptera, such as Anasa © tristis, Antestiopsis spp., Blissus spp., Calocoris spp, Campylomma livida, long Cavelerius spp., Cimex spp., Creontiades 2〇dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Red bee Dysdercus SPP·), Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., leaf foot margin Leptoglossus phyllopus), blind 78 200926984 Lygus spp., Macropes excavatus, Miridae, ezara spp., Oebalus spp., Pentomidae ), Piesma quadrata, Piezodorus spp., Psallus seriatus, Pseudacysta persea, Rhodnius spp., Sahlbergella singularis, black pelicans

Scotinophora spp.), Stephanitis nashi, Tibraca spp., Triatoma spp. From the homoptera (Homoptera), such as Acyrthosipon spp., from Aeneolamia spp., Agonoscena spp., Aleurodes spp_, Aleurolobus barodensis ), Aleurothrixus spp., Amrasca spp., Anuraphis cardui, Aonidiella spp., Aphanostigma piri, insects Aphis spp.), Arboridia apicalis, Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthum solani, bemisia Spp.), Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Calliz (Calligypona 1113, 0^&), Lihuangtou big leafhopper (€&amp ;1*116006卩11&1&1?111 layer 1 (1&), Ganyan cotton 20 (Ceratovacuna lanigera), Morpho Cercopidae)

Ceroplastes spp.), Chaetosiphon fragaefolii, Indonesian Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus, Leafhopper (Cicadulina mbila), Shield 79 200926984 (Coccomytilus halli), Coccus spp., Cryptomyzus ribis, Dalbulus spp., Dialeurodes spp., Muzi ( Diaphorina spp.), Diaspis spp., Doralis spp., Drosicha spp., Dysaphis 5 spp., Dysmicoccus spp., Empoasca Spp.), Eriosoma spp., Erythroneura spp., Euceleli bilobatus, Geococcus coffeae, Homalodisca coagulata, peach Powder (Hyalopterus 5 arundinis), Iceryaspp., Idiocerusspp·, Idioscopus spp., Laodelphax striatellus, Lecanium spp. ), Lepidosaphes spp., fake vegetables (Lipaphis erysimi), Macrosiphum spp., Mahanarva fimbriolata, Melanaphis sacchari, Metcalfiella spp., Metopolophium 15 dirhodum, yellow walnut Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp., Nilaparvata lugens, Ye Wei Oncometopia spp.), Orthezia praelonga, Parabemisia myricae, Paratrioza spp., pariat〇ria spp., Pemphigus spp. ), corn fly (peregrinus maidis), brocade (卩) 1611 &〇(;0115 8卩卩.), flat-winged cotton money (1>]11〇6〇111}^115卩&3861411丨0, Phorodon humuli, Phylloxera spp. , Pinnaspis aspidistrae, Planococcus spp., 200926984 Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp. , Psylla spp., Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesada gigas, 5 (Rastrococcus spp.), Rhopalosiphum spp., Saissetia spp., Scaphoides titanus, Schizaphis graminum, Selenaspidus articulatus, flying insects (Sogata spp.), Sogatella ® furcifera, Sogatodes spp., Stictocephala 10 festina, Tenalaphara malayensis, Tinocallis caryaefoliae, medlar ( Tomaspis spp.), Toxoptera spp., greenhouse white ^^ (Tria Leurodes vaporariorum), Trioza SPP., Typhlocyba spp., Unaspis spp., Viteus vitifolii. 15 From Hymenoptera, such as the leaf bee (Diprion SPP.), Leaf bee (Hoplocampa spp.), Field ant (Lasius spp.), Xiao Huangjia © Sacrifice (]^1〇11〇111〇1^11111卩11&〇1^8), Vespa (Vespa spp_). From Isopoda, such as Armadillidium vulgare, Oniscus asellus, Porcellio 20 scaber, from Isoptera, such as Reticulitermes spp, Odontotermes spp. ° From Lepidoptera, such as Acronicta major, Aedia leucomelas, and Earth tiger 81 200926984 (Agrotis spp. ), Alabama argiliaceae, Anticarsia, Barathra brassicae, Bucculatrix thurberiella, Bupalus piniarius, Dianthus moth (〇3(;06( ^卩0(1&plus), Noctuidae (€&卩1^代1^111&1^), Ping Carpocapsa pomonella, Cheimatobia brumata, Chilo spp., Choristoneura fumiferana, Clysia ambiguella, Cnaphalocerus spp. Erios insulana, Ephestia ® kuehniella, Euproctis chrysorrhoea, Euxoa 10 spp., Feltia spp., Galleria mellonella , Cotton mites (Helicoverpa spp.), Heliothis spp., Hofmannophila pseudospretella, Homona magnanima, Hyponomeuta padella, Laphygma spp., fine Lithocolletis blancardella, Lithhophane antennata, Loxaltis albicosta, Lymantria spp., Malacosoma neustria, Mamestra brassicae, Noctuidae Mocis repanda), Mythimna separata, Oria spp., Oulema oryzae, Panolis flammea, Pectinophora 2〇gossypiella , Phyllocnistis citrella, Pieris spp., Plutella xylostella, Prodenia spp., Musca domestica (卩3611<1316also 3卩卩.), soybean night moth(? 3611(!〇卩11^3 111〇111(16113), corn mold (Pyrausta nubilalis), night moth (Spodoptera spp.), Lido noctuidae (11^1:11^5丨&§611111^3 he ), the shelled moth (^1^&卩6111〇1^11&), clothing 82 200926984 moth (Tineola bisselliella), Tortrix viridana, and the genus Trichoplusia spp. Orthoptera, such as Acheta domesticus, Blata orientalis, Blattella 5 germanica, Gryllotalpa spp., Leucophaea maderae, Locusta spp. , Melanoplus spp., Periplaneta americana, Schistocerca gregaria ° ® from Siphonaptera, such as Ceratophyllus 10 spp·, Indian groin Xenopsylla cheopis). From Synphyla, such as Scutigerella immaculata. From Thysanoptera, such as Baliothrips biformis, Enneothrips flavens, and Floriniella 15 Spp.), Lima (Heliothri Ps spp·), Hercinortirips femoralis, Kakothrips spp·, Rhipiphorothrips cruentatus, Scirtothrips spp·, Taeniothrips cardamoni, Thrips spp .) From the genus Thysanura, such as Lepisma 2〇saccharina ° Plant parasitic lines: & For example, including Anguina spp., Aphelenchoides spp., Nematodes (Belonoaimus) Spp_), Bursaphelenchus spp., Ditylenchus dipsaci, Globodera spp., Helicoverpa armigere 83 200926984 5 Ο 10 15 〇20 (Heliocotylenchus spp.), cystic nematode (Heterodera) Spp.), Longidorus spp., Meloidogyne spp., Pratylenchus spp., Radoclonus similis, Rotylenchus spp., Trichodorus spp .), Dylenchorhynchus spp., Tylenchulus SPP., Tylenchulus semipenetrans, Xiphinema spp. The active compound composition of the invention is not only used as a pest against plant products, sanitary products and storage products, but also used in the field of veterinary medicine against animal parasites (in vitro or in vivo parasites), such as hard palate, cockroach, leafhopper , flies (skull or bite), parasitic fly larvae, head lice, feathers and fleas. These parasites include: From Anoplurida, such as Haematopinus spp., Linognathus spp., Pediculus spp., Phtirus spp., Solenopotes spp. ). From Mallophagida and Amblycerina and Ischnocerina, such as Trimenopon spp., Menopon spp., Trinoton spp., Maz Bovicola spp .), biter insect (Werneckiella spp.), Lepikentron spp., Damalina spp., Trichodectes spp., Felicola spp. From Diptera (Nematocerina) and Brachycerina, such as Aedes spp., Anopheles spp., Culex spp., spinning (Simulium spp.), Eusimulium spp., Phlebotomus spp., Lutzomyia spp., Culicoides spp., Chrysops 84 200926984 spp., tumor it (Hybomitra spp.), yellow it (Atylotus spp.), Tabanus spp., Haematopota spp., it (Philipomyia spp.), bee worm (Braula spp.), family rope (Musca spp. ), tooth rope (Hydrotaea spp.), Stomoxys spp., Haematobia 5 spp., Morellia spp., Fannia spp., Glossina spp. ), Calliphora spp., Lucilia spp., Chrysomyia spp., Wohlfahrtia spp., Sarcophaga spp., Oestrus spp. Hypoderma spp., Gasterophilus spp., Hippotosca spp., Lipoptena spp., Melophagus spp. ° from Siphonapterida For example fleas (Pulex spp.), Angular leaf fleas (Ceratophyllus spp ·), the rat flea (Xenopsylla cheopis). From Heteropterida, such as bed bug (Cimex spp.), Triatoma spp., Rhodnius spp., Panstrongylus spp. ° From the cockroach (Blattarida) ), for example, Blatta © orientalis, Periplaneta americana, Blattela germanica, Supella spp. From Acari (Acarina) and Meta- and 2-Mesostigmata, such as Argas spp., Ornithodoros spp., Otobius spp .), Ixodes spp., Amblyomma spp., Boophilus spp., Dermacentor spp., Haemophysalis spp., Hyalomama spp. ), Rhipicephalus spp., larvae 85 200926984 (Dermanyssus spp.), Raillietia spp., Pneumonyssus spp, Steraostoma spp. Varroa spp.). From Actinedida [Prostigmata] and Acaridida [Astigmata], such as Acarapis spp., Cheyletiella spp. , Parasitic worm (Ornithocheyletia spp.), Myobia spp., Psorergates spp., Demodex spp., Trombula spp., Listrophorus spp. , Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes SPP. Choriopteres spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp., membrane Laminosioptes spp ° The compound composition/composition of the present invention is also suitable for controlling infected agricultural production of livestock such as cattle, sheep, goats, horses, pigs, donkeys, road sharps, buffalo, rabbits, chickens, turkeys, ducks Goose and bees, other pets such as dogs, cartons, cage birds and aquarium fish, and so-called trials Animals such as hamsters, guinea pigs, rats and mouse arthropods. By controlling these arthropods, it is possible to reduce the death and productivity (degradation of meat, milk, hair, leather, eggs, honey, etc.) and to make animal husbandry more economical and more efficient by using the active compound composition of the present invention. easily. The active compound composition/composition of the present invention can be used in the veterinary field, by enteral administration in a known manner, for example, by spinner, knee, agent, syrup, granule, _, group Block, feedthrough and test form 'straw' is administered parenterally, for example by injection (intramuscular, intravenous, intraperitoneal, and the like), implantation, by intranasal administration, by skin For example, in the form of dripping, bathing, spraying, pouring, spotting, rinsing, powdering, and molding products containing active compounds, such as collars, ear rods, tails, foot straps, reins, printing devices and the like Assistance with analogues. τ ❹ 10 15

20 When used in cattle, poultry, pets, etc., the active compound composition can be used as a formulation (for example, a powder, an emulsion, a flowable composition) comprising an amount of the active compound in a weight ratio of 1 to 8 G% directly or diluted. _• Use after double, or it can be used as a chemical bath. Furthermore, it has been found that the active compound compositions of the present invention also have insecticidal action against insects which are highly resistant to industrial materials. The following insects may be mentioned as examples and are preferred _ but not limited to: locusts such as Hylotrupes bajulus, snails (〇11〇1:0卩1101:118卩11〇318) ), furniture burglary (eight 11 (^11111 卩 melon 1 gamma; 11111), red thief (Xestobium rufovillosum), Ptilinus pecticornis, (Dendrobium pertinex), pink thieves (Ernobius Mollis), Priobium carpini, Lyctus brunneus, Lyctus africanus, Lyctus planicollis, Lyctus linearis, Lyctus pubescens , Trogoxylon aequale, Minthes rugicollis, Xyleborus spec., Tryptodendron spec., Apate monachus, (Bostrychus capucins), 87 200926984 Heterobostrychus brunneus, Sinoxylon spec., Dinoderus minutus, Hymenoptera, such as Sirex juvencus, Urocerus gigas, Thai Increase tree bee (Urocerus gigas taignus), saw 5 Bee (Urocerus augur); termites, such as Kalotermes flavicollis, Cryptotermes brevis, Heterotermes indicola, Reticulitermes flavipes, Sant's white ants (Reticulitermes santonensis), Southern European Reticulitermes lucifugus, Mastotermes darwiniensis, Zootermopsis nevadensis, Coptotermes formosanus, Bristletails, For example, Lepisma saccharina. For this item, industrial materials should be understood to mean inanimate substances, for example, 15 preferably plastics, adhesives, sizes, paper and board, leather, wood and processed wood products and film coating compositions. ❹ A ready-to-use composition, if appropriate, may additionally comprise an insecticide and, if appropriate, one or more fungicides. With regard to possible additional additives, it is preferred to use the above-mentioned insecticides and bactericidal agents. The active compound compositions/compositions of the present invention are equally useful for protecting articles that are in contact with seawater or salt water, such as skins, screens, nets, buildings, bows, and messaging systems. Further, the active compound composition/composition of the present invention may be used alone or in combination with other active compounds of 88 200926984 as an antifouling agent. In the protection of household, sanitary and storage products, the activated eight composition / composition is also suitable for controlling animal pests, especially in the case of closed hunger, such as::: factory: office, car temple, etc.) See worms, arthropods, and, can be supplemented or combined with other active bismuth and gamma synthetic household killing products 'to control this (4) 4 . It also has the activity of surface-sensing and anti-sex species, as well as the activity of the anti-funding section. These pests include:

10 15

20 From Scorpionidea, for example, Buthus occitanus ° From Acarina ', such as Argas persicus, Argas reflexus, Bryobia Ssp.), Dermanyssus gallinae, Glyciphagus domesticus, Omithodorus moubat, Rhipicephalus sanguineus, Trombula alfreddugesi, Neutrombicula autumnalis ), European worm (Dermatophagoides pteronissimus), American worm (Dermatophagoides forinae). From Araneae, for example, Aviculariidae, Araneidae. From the oppilione 'Pseudoscorpiones chelifer, Pseudoscorpiones cheiridium, Opileons phalangium 0 from Isopoda' such as wall worm (〇niscus asel us), 89 200926984 Ball cello (Porcellio scaber). From the genus Diplopoda, such as the Blancois guttulatus, Polydesmus spp. From the order of the Chilopoda, such as Geophilus spp. 5 From Zygentoma, such as Ctenolepisma spp·, Lepisma saccharina, Lepismodes inquilinus, from Blattaria, such as Blatta ❹ orientalis, German 蟑螂 (Blattela germanica), Asian 蟑螂ίο (Blattella asahinai), Florida 蟑螂 (Leucophaea maderae), chlor (Panchlora spp.), 蠊 (Parcoblatta spp.), 蟑螂 (Periplaneta australasiae), American 蟑螂 (Periplaneta americana) , Periplaneta brunnea, Periplaneta fuliginosa, Supella longipalpa. 15 From the Saltatoria, such as the Acheta domesticus ° 〇 From the Dermaptera, for example, Forficula auricularia ° From the Isoptera, such as the wood termite (Kalotermes spp· ), 20 Termites (Reticulitermes spp.). From the order of Psocoptera, for example (Lepinatus spp.), Liposcelis spp. From Coleoptera, for example, Anthrenus spp., Attagenus spp., Dermestes spp., Long-headed foxes 200926984 (Latheticus oryzae), Necrobia spp. Ptinus spp, Rhizopertha dominica, Sitophilus granaries, Sitophilus oryzae, Sitophilus zeamais, Stegobium paniceum. 5 Ο 10 15 ❹ From Diptera, such as Aedes aegypti, Aedes albopictus, Aedes taeniorhynchus, Anopheles spp., red-headed rope (Calliphora erythrocephala), Chrysozona pluvialis, Culex quinquefasciatus, Culex pipiens, Culex tarsalis, Drosophila spp., Summer rope ( Fannia canicularis), Musca domestica, Phlebotomus spp., Sarcophaga carnaria, Simulium spp., Stomoxys calcitrans, Tipula paludosa Lepidoptera, such as Achroia grisella, Galleria mellonella, Plodia interpunctella, Tinea cloacella, Tinea pellionella, Tineolabisselliella 〇 From Siphonaptera, such as Ctenocephalides canis, Ctenocephalides felis, Pulex irritans, Tunga penetrans Xenopsylla cheopis ° From Hymenoptera, such as Camponotus herculeanus, Lasius fuliginosus, black 20 200926984 ant (Lasius niger), shade ant (Lasius umbratus) ), Monomium pharaonis, Paraspula spp., gray-black wrinkled ants (Ding 6 hit & 1110 ^ 111110868 harassment 11111). From Anoplura, for example, Pediculus humanus 5 capitis, Pediculus humanus corporis, Pemphigus spp., Phylloera vastatrix, Phthirus pubis Heteroptera, such as Cimex © hemipterus, Cimex lectularius, Rhodimis prolixus, Triatoma infestans, in the field of household insecticides, either alone or in combination with others Suitable active compounds, for example phospholipids, amidoxime esters, pyrethroids, neonicotinoids, growth regulators or active compounds from other classes of insecticides, are used in combination. It can be used in aerosol, non-pressure spray products such as pumps and atomizers 15 sprays, automatic spray systems, fog machines, foams, gels, steam ingots made of cellulose or polymers. Evaporator products, liquid evaporators, gel cartridges and membrane evaporators, propeller evaporators, energy-free or passive evaporation systems, moth paper, moth bags and moth glue, used as granules or powders to spread bait or for bait station. Further, the compositions and compositions of the present invention can also be used to reduce the amount of mycotoxin in plants and harvested plant material, and thereby reduce the amount of mycotoxins from the food and animal feed therefrom. Special (but not absolute) can be noted for the following mycotoxins: Deoxynivalenole (DON), Snow Rouge 92 200926984 Nivalenole, 15-Ac-DON, 3-Ac- DON, T2- and HT2-toxin, Fumonisines, Zeallenone, Moniliformine, Fusarine, Fusarium oxysporum Enaceotoxyscirpenole (DAS), Beauvericine, Enniatine, Fusaroproliferine, Fusarenole, Ochratoxines, Patuline, ergot-like bioassay, and Aflatoxine, which are caused by, for example, the following fungal diseases: Fwsar/wm, 10 such as Fusarium oxysporum (FMSflrzww, F. avenaceum, F. crookwellense, Fusarium oxysporum (F. cw/morwm), Fusarium graminearum (F· not #气), Fusarium oxysporum (F., Fujikura sickle) Bacteria (K / «力如(10)·), Fusarium oxysporum (i7· mwsarwm), (K, re-education Phytophthora (F. 15 , Fusarium oxysporum (F., Fusarium graminearum (F., Fusarium oxysporum (10), (10), Fusarium oxysporum (10), Fusarium oxysporum (F·sewnYeciwm), solanosis sickle brine (_F. so/owz·), Rhizoctonia sphaeroides (F. also 5), powdered F. langsethiae, and sputum X) F. subglutinans), Fusarium oxysporum (F. sylvestris), Fusarium oxysporum (f. ve(9)·c/z/zWi/e*?), and others 4麴ergz7/ Mly), Penicillium 5/7%.), C. avceps pwrpwrea, S. cerevisiae spec. and other bacteria. Very good fungicidal effect of the composition or composition of the present invention. Line 93 200926984 is shown in the following example. When a single active compound exhibits a weak killing time, the composition or composition shows greater than a single compound effect: phase two effect ι> >

Ο 10 15

20 According to Kobe (S_R. Colby) ("Computation of synergistic and anti-reaction reactions of herbage-age compounds", Weeds 1967, 15, 20-22), if the fungicidal efficacy of the novels of the present invention is greater than two or three The synergistic effect of the fungicide is really present when the active compound is used. The calculation is as follows: If x is the potency observed for the compound (A) at the defined dose (mppm), γ is The potency observed for compound (B) at a defined dose (n ppm), Z is the potency observed for compound (A) at a defined dose (rppm), and E1 is the compound (A) and compound (B) Efficacy observed for defined m and n ppm doses, E2 is the potency observed for compound (A) and compound (B) and compound (combined at defined m, n and rppm doses, for binary mixtures) The Colby equation can be defined as follows:

X · Y E1=X+Y-- 100 and for the ternary mixture: Ε2=Χ+γ+ζ_ (X · Υ+Χ · Ζ+Υ · Ζ) (X · Υ · Ζ) 10000 94 100 25 200926984 The degree of effectiveness of Shizhili is expressed in %. 0% means one with the control group and 100% means that no disease is observed. Calculated Observed 5 If the actual observed fungicidal activity is greater than the expected efficacy using the Kobe equation, the composition or composition is superadditive, i.e., synergistic. The invention is illustrated by the following examples. [Examples] © Example 1 10 Magnaporthe oryzae test (rice > / preventive solvent: 50 parts by weight of hydrazine, hydrazine-dimethyl decyl amide emulsifier · 1 part by weight of alkyl aryl polyethylene glycol Ether 1 part by weight of the active compound is mixed with the amount of solvent and emulsifier to produce a suitable preparation of the active compound and the concentrate is diluted with water to the desired concentration. The dose of the active compound preparation is sprayed and tested for prophylactic activity. When the spray coating is dried, the plant is sprayed with a suspension of the sphagnum sinensis/spindle. The plant is then placed in a set. The atmosphere was measured in a greenhouse of 2 Torr and 250 C. This test was evaluated 10 days after inoculation. 〇% means the efficacy consistent with the control group, and 100% of the efficacy means no disease observed. 95 200926984 Table 1 Rice Phytophthora test (m) / prophylactically active compound is known: The amount of active compound administered is expressed in ppm. Efficacy is expressed in %. Isotaxil N\S Γι °1rVNO 25 57 Idamine 0 0 25 0 25 0 96 200926984 Known compound composition: mixed The proportion of active compound administered in ppm is expressed in ppm. The actual potency is expressed in %. The expected value calculated using the Kobe equation is Isosoni + EDTA} 1:1 25+25 } 71 57 Issotelny + } 1:1 25+25 } 71 57 EDTA + 诺诺杀} 1:1 25+25 } 57 0 Known compound composition: The actual potency of the active compound of the mixture uses the Kobe equation

The proportional dose is expressed in ppm. The period is expressed in ppm. 25 Isoprofenil} 1 : 1:1 25 } 93 57 + + Nisko 25 97 200926984 Example 2 B. powdery mildew Test (barley)/5 days prevention solvent: 50 parts by weight of η, η-dimethylhydrazine emulsifier: 1 part by weight of alkyl aryl polyglycol ether 1 part by weight of active compound or active compound The composition is combined with the amount of solvent and emulsifier to produce a suitable preparation of the active compound' and the concentrate is diluted with water to the desired concentration. The test for the prophylactic activity of the young plant is carried out by spraying the active compound preparation or the active compound and the hydrazine compound in the stated amount. Five days after the spraying, the plants were sprinkled with spores of Blumeria graminis f.sp. hordei. The plants are placed at a temperature of about 2 Torr. (: and the relative atmospheric humidity of about 8〇% in the greenhouse to accelerate the development of mold cues. This test was evaluated 7 days after vaccination. q% Hao consistent with the control group's efficacy' and the effect means no observed disease 98 200926984 Table 2 B. powdery mildew (barley) / 5 days prevention

Active Compounds Known: The amount of active compound administered is expressed in ppm. The potency is expressed in %. N Isoxanil 丨丨 c1rVNt) 100 0 达达胺〇0 丨100 0 (S)-3-chloro-Nl-{2-对 to palmyl-4-[1,2,2,2-tetrafluoroindole 1 I g -1-(trifluoromethyl)ethyl]phenyl} -N2-(1-methyl_2-fluorenyl醯 醯 乙基 ethyl) decylamine 100 0 99 200926984

Known compound composition: mixed compound ratio active compound practical effect using Kobe equation pre-quantity in ppm expressed in % expressed as the period of time expressed as Isosolny + } Yidaamine 1:1 100+100 } 71 57 Isoxilil + (S)-3-chloro-Nl-{2-mercapto-4-[l,2,2,2-tetrafluoro}-1-(trifluoromethyl)ethyl]benzene }}-Ν2-(1-methyl-2-mercaptosulfonylethyl) urethane 1:1 100+100 } 29 57 EDTA + (S)-3-chloro-Nl-{2- Methyl-4-[1,2,2,2-tetrafluoro} 4-(trifluoromethyl)ethyl]phenyl}-indole 2-(1-indolyl-2-methylsulfonylethyl) EA: 1:1 100+100 } 29 0 Isoxanil + EDTA 100 + + (S)-3-chloro-Nl-{2-methyl} 1:1: 1 100 } 86 0 -4 -[l,2,2,2-tetrafluoro+-1-(trifluoromethyl)ethyl]phenyl}-indole 2-(1-mercapto-2-indolylsulfonylethyl) decylamine 100 100 200926984 The expected enthalpy of the composition of the two compounds administered as a formula for the composition of a compound is calculated as follows (see S. R. Colby, "Synthesis of the synergistic and antagonistic reaction of the herbicidal composition," Weeds 15, 20-22 pages 1967): •5 If X is test compound A at each mppm concentration is tan g/ha, with untreated control ❶/. The effect of mortality is 'Y is the test compound Β at !ippm concentration individual iig/ha, The efficacy expressed as % mortality of the untreated sputum control group, ίο Z is the efficacy of test compound C at appm concentration of gg/ha, expressed as % mortality of the untreated control group, and E is the use of test compounds A, B. And the mixture of C at m, η, and 〇ppm were Ώΐ n and 〇g/ha 'the efficacy of % mortality in the untreated control group, 15

XY+YZ+XZ XYZ E=X+Y+Z------ ❹ 100 10000 If the observed insecticidal efficacy of the composition is higher than the calculated "E", then the composition of the two compounds is high. "Effects on the addition of the union" is also synergistic. 101 200926984 Example 1 Cotton worm (Heliothis armigera) test solvent: 7 parts by weight of dimethylformamide emulsifier: 2 parts by weight of alkyl aryl polyglycol ether 1 part by weight of active compound and said The amount of solvent and emulsifier are combined to produce a suitable preparation of the active compound, and the concentrate is diluted to the desired concentration with water containing the emulsifier. The soybean leaves max) are sprayed with a preparation of the active compound of the desired concentration and infected with the larvae of cotton aphids while the leaves are still moist. '^ After a specific period of time, the mortality expressed in % is determined.丨 (10)% means that all caterpillars are killed; 0% means that no caterpillars are killed. According to the application of this test, for example, the following composition, exhibits synergistic effect compared to a single compound: 102 200926984 Table 3: Helicoverpa armigera (Heliothis armigera) test active ingredient concentration expressed in ppm, efficacy after 4 days represents Sothoni 200 0 EDTA 4 0 Fenpney 4 70 Isoxanil + EDTA + Fenpney (50 : 1 : 1) According to the invention 200 + 4 + 4 obs1 cal. 2 100 70

103 1 obs.=Measured insecticidal efficacy 2 * 1cal.=Effect calculated by Kobe equation 200926984 Example 4 Nilaparvata lugens - Test solvent: 7 parts by weight of dimethyl decylamine emulsifier: 2 Parts by weight of leucoaryl polyglycol ether 1 part by weight of the active compound are mixed with the amount of solvent and emulsifier to produce a suitable preparation of the active compound, and the concentrate is diluted with water containing an emulsifier The desired concentration. The rice plant is treated with "like" sprayed with the preparation of the active compound of the desired concentration and infected with the larvae of the brown flies (Nilaparvata / wgew??) while the leaves are still wet. After a certain period of time, the mortality in % is determined. 1〇〇% is that all the larvae of the planthopper are killed; 0% means that no larvae are killed. According to the application of this test, for example, the following compositions, compared to a single compound, synergistic effect: , 104 200926984 Table 4: Nilaparvatalugens - test active ingredient concentration expressed in ppm, expressed in 4 days after % Sothani 200 0 EDTA 4 20 Ethionine 0,16 0 Isoxanil + EDTA + Ethylamidine (1250 : 25 : 1) According to the invention 200+4+0,16 obs1 cal.2 45 20

105 1 obs.=Measured insecticidal efficacy 2 cal.=Effect calculated by Kobe equation 200926984 Example 5 Phaedon cochleariae - Test solvent: 7 parts by weight of dimethylformamide Emulsifier: 2 weight Alkylaryl Polyglycol Ether A 1 part by weight of the active compound is mixed with the amount of solvent and emulsifier to yield a suitable preparation of the active compound, and the concentrate is emulsified Dilute to the desired concentration. The cabbage leaf racea) is sprayed with a preparation of the active compound of the desired concentration, and the leaf beetle {Phaedon cochleariae, the oily insect, is used when the leaves are still wet. After a certain period of time, the mortality in % is determined. 1〇〇 〇/〇 means that all beetle larvae are killed; 0% means that larvae without any beetles are killed. According to the application of this test, for example, the following compositions exhibit synergistic effects compared to a single compound: 106 200926984 Table 5-1 · Phaedon cochleariae - Test active ingredient concentration Expressed in ppm, after 4 days % Indicates that Isotaxil 200 0 etalide 4 0 N-[2-(l,3-dimethylbutyl)phenyl]-5-fluoro-1,3-didecyl-1H-° than 唆- 4-carboxylic acid amine 200 0 Isoxanil + EDTA + Ν-[2-(1,3-dimercaptobutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyridyl Oxazol-4-carboxamide (50: 1 : 50) according to the invention 200+4+200 obs1 cal.** 25 0 *obs.=measured insecticidal efficacy 107 1 1cal.=effectiveness calculated by Kobe equation 200926984 Table 5-2: Phaedon cochleariae - Trial

The active ingredient concentration is expressed in ppm and the potency is expressed in ppm after 4 days. Isotaxil 200 0 etalide 20 35 4 5 Metominostrobin 200 0 Isoxanil + EDTA + phenoxystrobin (10 : 1 : 10) According to the invention 200+20+200 obs1 cal.2 90 34,65 诺诺杀0,8 10 Isoxil + ideamine + chlorhexidine (250 : 5 : 1) according to the invention 200+4+0,8 obs1 cal.2 80 14,5 108 1 obs.=Measured insecticidal efficacy 2 cal.=Effect calculated by Kobe equation 200926984 Example 6 Spodoptera frugiperda Test solvent: 7 Parts by weight of dimethylformamide emulsifier: 2 parts by weight of alkylaryl polyglycol ether 5 Mix 1 part by weight of active compound with the amount of solvent and emulsifier' to produce suitable active compound The preparation is prepared and diluted to a desired concentration with water containing an emulsifier. The cabbage leaves (5r like a heart) are immersed in the preparation of the active compound of the desired concentration and are infected with the larvae of the autumn worm (Spodopterafrugiperda) while the leaves are still wet. After a certain period of time, the mortality in % is determined. 1〇〇% means that all caterpillars are killed; 0% means that no caterpillars are killed. According to the application of this test, for example, the following composition showed synergistic effect compared to a single 15 compound: ❹ 109 200926984 Table D: Spodopterafrugiperda test active ingredient concentration expressed in ppm, efficacy after 6 days, Aesop Tony 200 10 idacamin 0,8 0 (S)-3-chloro-Nl-{2-methyl-4-[l,2,2,2-tetrafluoro-1-(trifluoromethyl) Benzene*}-Ν2-(1-mercapto-2-methylsulfonylethyl) decylamine 0,16 55 Isoxanil + EDTA+(S)-3-Gas-Nl- {2-Methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}-indole 2-(1-indolyl-2-methyl hydrazino Ethyl) decylamine (1250: 5: 1) according to the invention 200+0,8+0,16 obs* cal.1 100 59,5 *obs.=measured insecticidal efficacy 110 1 cal.=Kobe The effect calculated by the equation

Claims (1)

200926984 VII. Scope of application: i A composition comprising: (A) 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolylcarbamide, and (B) edetamine (imidacloprid), and 〇10 * « 2. ❹ (C) The additional active compound is selected from the group consisting of the following fungicidal and insecticidal active compounds: ethiprole, fipronil, Thiacloprid, spinosad, thifluzamide, (S)-3, chloro-Nl-{2-mercapto-4-[l,2,2,2-tetrafluoro -1-(trifluoromethyl)ethyl]phenyl}-indole 2-(1-mercapto-2-indenylethyl)-decylamine, N-[2-(l,3-diindole) Butyl)phenyl]-5-fluoro-1,3-dimercapto-1H-. Than "sit-4-amine. The composition of claim 1, wherein the weight ratio of the two components (A), (B) or (C) is independently 1: 1 〇〇 to 1 〇〇: 1 ° A composition comprising the composition of claim 1 or 2 of the patent application. 4. The composition of claim 1 or 3, further comprising an adjuvant, a solvent, a carrier, a surfactant or a extender. 5. A method for the therapeutic or prophylactic control of phytopathogenic fungi and/or microorganisms and/or pests of plants or crops, comprising the use of a fungicide and/or insecticide composition as claimed in claim 4, Planting 111 200926984 Sub-plant, plant-propagating material, plant or plant fruit or plant growth or soil for growth of humans. 0 6. The method of claim 5, including simultaneous or sequential application of compound (A), ( B) and (〇. ❹ 10 15 20 7. The method of claim 5, wherein the amount of the composition/composition of the patent application range 1 to 3 is from 0.1 g/ha to i〇kg for leaves and soil. /ha, the seed is treated from 2 to 2 grams / 100 kg. 8. Use of a composition as claimed in claim 1 for the treatment of seeds. 9. For the purpose of applying for the scope of patent application, it is used for the treatment of genetically modified seeds. 10. A method for protecting seeds and/or buds and leaves of plants grown from seeds from pest or fungus damage, the method comprising treating unseeded seeds with a composition as in claim 1 of the patent application. U. The method of claim 10, wherein the seed is simultaneously treated with the compounds (A), (B) and (C). 12. The method of claim 11, wherein the seed is treated separately with the compounds (A), (B) and (C). 13. Seeds treated with a composition as claimed in claim 1 of the patent application. 112 200926984 IV. Designation of representative drawings: (1) The representative representative of the case is: (No). (2) A brief description of the symbol of the representative figure: M. 〇 10 5. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: None • 15 200926984 website. These descriptions are based on the extension of the application - the extension of the previous application request. - Institution: The name of the entity making the application. - Controls: The species of plants involved. - Gene to lean phenotype: the characteristics conferred by plants by genetic transformation. - Transformed lines or strains: Names of objects without regulatory requirements (sometimes referred to as plants) APHIS documents: Documents issued by APHIS relating to the application and available to APHIS.