KR101545181B1 - Ternary active compound combinations - Google Patents

Abstract

The present invention relates to a pharmaceutical composition comprising (A) 3,4-dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide, (B) imidacloprid and (C) one insecticide or fungicidally active compound Especially fungicides or combinations of the active compounds in insecticidal compositions.
The present invention also relates to a method of curative or prophylactic remediation of phytopathogenic fungi and / or microorganisms and / or pests of plants or crops, the use of the formulations according to the invention for treating plant propagation, seed protection methods and above all Lt; / RTI >

Description

Ternary active compound combinations < RTI ID = 0.0 >

The present invention relates to (A) 3,4-dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide (generic name: isothianil, CasNo 224049-04-1), (B) imidacloprid And (C) a combination of active compounds comprising one insecticidal or fungicidally active compound, especially a combination of said active compounds in fungicides or insecticidal compositions. The present invention also relates to a method of curative or prophylactic remediation of phytopathogenic fungi and / or microorganisms and / or pests of plants or crops, the use of the formulations according to the invention for treating plant propagation, seed protection methods and above all Lt; / RTI >

(A) It is already known that 3,4-dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide has fatigue and insolubility. It has also been found that isothiazolecarboxylic acid derivatives are very suitable for protecting plants from undesirable phytopathogenic fungi and microorganisms (see US-A 5 240 951 and JP-A 06-009 313). The compound (A) according to the present invention is suitable as an antimicrobial agent for mobilizing the defense of plants against unwanted phytopathogenic fungi and microorganisms, and for directly rescuing phytopathogenic fungi and microorganisms. In addition, compound (A) is also active against insects that damage plants (WO 99/24414).

Compound (A) is 3,4-dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide and its preparation is disclosed in WO 99/24414. The activity of this compound is excellent, but it may be unsatisfactory when the application ratio is low.

Compound (B) is imidacloprid, the insecticidal compound described in EP-A 0 192 060. The compound (C) can be prepared by reacting a compound selected from the group consisting of ethioprol (known by DE-A 196 53 417), fipronil (known by EP-A 0 029 117), thiacloprid (by EP A 0 235 725 (S) -3-chloro-N ¹ - {2 (as described in EP-A 0 371 316), thiuramine -methyl-4- [(trifluoromethyl) -1-a 1,2,2,2- tetrafluoro-ethyl] phenyl} -N ² - (1- methyl-2-methylsulfonyl-ethyl) phthalamide (EP -A 1 006 107) and N- [2- (1,3-dimethylbutyl) phenyl] -5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide 0.0 > WO 03/010149). ≪ / RTI >

Binary combinations of one of the compounds (B) and (C) are disclosed in the following references (WO 2005/122796; EP-A 0 871 362; WO 2005/036966; WO 1999/060857; WO 2007 / 101542; WO 2006/114212). It is also known that the combination of isothianyl and neonicotinoids is suitable for the relief of phytopathogenic fungi (WO 2005/009131).

Today's fungicides and pesticides are subject to environmental and economic requirements, for example for action spectrum, toxicity, selectivity, application rate, residue formation and advantageous manufacturability, and also for example resistance to known active compounds It is a constant challenge to develop new fungicides and pesticides that have advantages over their known counterparts in at least some areas.

The present invention provides, in some respects, a formulation / composition of active compounds, at least for the purposes indicated.

Surprisingly, the combination according to the invention not only improves additively the action spectrum against the phytopathogenic fungi and / or microorganisms and / or insects to be rescued, but also the effect of the compounds (A), (B) and It has been found that the synergistic effect can be achieved by providing the working range in the following two ways. First, the application ratio of the compound (A), the compound (B) and the compound (C) is reduced, but the action remains excellent as it is. Second, the combination provides a high degree of relief to plant pathogens even when three individual compounds are not entirely effective in the range of low application rates. Thus, on the one hand, the spectrum of the rescuable plant pathogenic bacteria can be broadened considerably, and on the other hand, the stability can be increased during use.

However, in addition to the substantial synergy with fungicidal and insecticidal activity, the killing-lavage combination according to the invention has, in a broader sense, another surprisingly advantageous property which can also be referred to as synergistic activity. As an example of such advantageous properties, Expansion of phytopathogenic fungi and / or fungus and insecticidal activity spectrum against microorganisms and / or insects, for example resistant bacteria; Reducing the application rate of the active ingredient; Sufficient insect pest control with compositions according to the present invention even at application rates where the individual compounds are not entirely effective; Favorable behavior during or during formulation, e.g., during grinding, sieving, emulsifying, dissolving or running; Increased storage stability; Improved light stability; More favorable degradability; Improvement of toxicological or ecotoxicological behavior; Improved germination, increased crop yield, better roots development, increased tillering, increased plant height, leaflet expansion, reduced root damage, more durable shoots, reduced green leaves, reduced fertilizer requirements, reduced seed requirements , More productive buds, early flowering, early kernel maturation, reduced verse (lodging), improved shoot growth, improved plant vitality and improved germination of useful plants including early germination; Or any other benefit that is well known to those skilled in the art.

The formulations according to the invention may also improve the systemic properties of the active compound used. Indeed, even if some of the fungicidal compounds used have no systemic or systemic unsatisfactory results, these compounds in the compositions according to the invention may exhibit systemic properties.

In a similar manner, the persistence of the fungicidal effect of the active compound used by the combination according to the invention can be increased.

When the compound (A), the compound (B) and the compound (C) are used together or separately at the same time, the single compound (A) : ≪ / RTI > WO 05/009131), the phytopathogenic fungi and / or microorganisms and / or insects are eliminated.

Another advantage of the combination according to the invention is that it can achieve an increase in efficacy.

Therefore,

(A) 3,4-dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide,

(B) imidacloprid and

(C) Ethioprol, fipronil, thiacloprid, spinosad, thifluzamide, (S) -3-chloro-N ¹ - {2-methyl- 4- [1,2,2,2- trifluoro-1- (trifluoromethyl) ethyl] phenyl} -N ² - (1- methyl-2-methylsulfonyl-ethyl) phthalamide, and N- [2- (1,3- dimethylbutyl) phenyl] - Fluoro-1, 3-dimethyl-1H-pyrazole-4-carboxamide, and one further active compound selected from the group of fungicidal and insecticidally active compounds.

Most compounds of compound (B) and group (C) are mentioned in The Pesticide Manual, 13 ^rd edition, 2003. The compound (C) is described by a generic name. If a generic name is not available in the prior application, compound (C) is described by IUPAC-name.

Preferred combinations are as follows:

Compound (A) 3,4-Dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide and Compound (B) Imidacloprid and Compound (C)

Compound (A) 3,4-Dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide and Compound (B) Imidacloprid and Compound (C)

Compound (A) 3,4-Dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide and Compound (B) Imidacloprid and Compound (C) Thiacloprid,

Compound (A) 3,4-Dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide and Compound (B) Imidacloprid and Compound (C) Spinosad,

Compound (A) 3,4-Dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide and Compound (B) Imidacloprid and Compound (C)

, Compound (A) 3,4- dichloro -N- (2- cyano-phenyl) -5-isothiazolyl jolka carboxamide and compound (B) imidacloprid and Compound (C) (S) -3- ^chloro-1 -N - {2-methyl-4- [(trifluoromethyl) 1,2,2,2- tetrafluoro-1-ethyl] phenyl} -N ² - (1- methyl-2-methylsulfonyl-ethyl) phthalimide amides,

Compound (A) 3,4-Dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide and Compound (B) Imidacloprid and Compound (C) N- [2- Dimethylbutyl) phenyl] -5-fluoro-1, 3-dimethyl-1H-pyrazole-4-carboxamide.

The weight ratio of active ingredient compound is selected to provide the desired action, for example synergism. In general, the weight ratio may vary depending on the particular active compound. Generally, the weight ratio between any two compounds is independently from 100: 1 to 1: 100, preferably from 75: 1 to 1:75, more preferably from 50: 1 to 1:50 and most preferably from 25: : 1 to 1: 25. Further weight ratios between any two compounds that can be used in accordance with the present invention are independently from 250: 1 to 1: 250, from 200: 1 to 1: 200, from 150: 1 to 150: 1, It goes up.

Other weight ratios between any two compounds are independently from 90: 1 to 1:90, from 80: 1 to 1:80, from 70: 1 to 1:70, from 60: 1 to 1:60, from 40: : 40, 30: 1 to 1:30, 10: 1 to 1:10, 5: 1 to 1: 5, 4: 1 to 1: 4, 3: 1 to 1: 3, It goes up.

It should be understood that the compounds (A), (B) and (C) may exist as tautomers and, although they are not specifically mentioned in each case, these and the following compounds include the corresponding tautomers which are applicable.

The compound (A), the compound (B) and the compound (C) having at least one basic center can be prepared by reacting a compound of the formula Substituted C ₁ -C ₄ alkanecarboxylic acids such as halo-substituted, such as acetic acid, saturated or unsaturated dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid and phthalic acid, hydroxycarboxylic acids such as ascorbic acid, lactic acid , Strong organic carboxylic acids such as malic acid, tartaric acid and citric acid or benzoic acid, or substituted C ₁ -C ₄ alkane- or aryl-sulfonic acids such as unsubstituted or halo-substituted, such as methane- or p-toluenesulfonic acid Can form acid addition salts with organic sulfonic acids. The compound (A), the compound (B) and the compound (C) having at least one acid group can be converted into a salt with a base, for example, an alkali metal or an alkaline earth metal salt such as sodium, potassium or magnesium salt Such as sodium or potassium or a metal salt such as sodium or potassium or a metal salt such as ammonia or morpholine, piperidine, pyrrolidine, mono-, di- or tri-lower alkylamines such as ethyl-, diethyl-, triethyl- or dimethylpropylamine, Di- or tri-hydroxy-lower alkylamines, such as mono-, di- or tri-ethanolamines. In addition, corresponding internal salts may optionally be formed. In the context of the present invention, agriculturally useful salts are preferred. (A), the compound (B) and the compound (C) or salts thereof (hereinafter referred to as " free compound (A) (A), compound (B) and compound (C), respectively, as the case may be. This equivalence also applies to the tautomers of the compounds (A), (B) and (C) and their salts.

According to the present invention, the expression "formulation" is intended to encompass the form of a combined spray mixture composed of, for example, a single ready-mix form, a separate preparation of single compounds such as a tank mix, (A), compound (B) and compound (C), such as when one component is applied followed by a single active ingredient in combination with appropriate short intervals of several hours or days, do. Preferably, the order of application of compounds (A), (B) and (C) is not critical to the practice of the invention.

According to the present invention, the expression "pathogens" means all organisms that damage plants or any part of the plant.

According to the present invention, the expression "fungus" means all fungi and chromista organisms.

According to the present invention, the expression "phytopathogenic fungi" refers to all fungi and chromista organisms that damage plants or any part of the plant. Examples of the group that is classified as a bacterium is Ascomycetes (Ascomycetes), Basidiomycetes (Basidiomycetes), chytridiomycota (Chytridiomycetes), imperfect fungi (Deuteromycetes), article Romero bacteria (Glomeromyco-ta), micro sports Lydia (Microsporidia), zygomycota Zygomycota and anamor-phic fungi. An example of chromic ester is oomycota .

According to the present invention, the expression "microorganism" means all bacterial and protozoan organisms. Examples are Plasmodiophoromycetes .

According to the present invention, the expression "virus" means any virus that damages a plant or any part of the plant. Examples include DNA, RNA, and DNA and RNA reverse viral as well as subviral agents.

According to the present invention, the expression "insect pest" means all aschellinses and panartropoda organisms which damage plants or any part of the plant. Examples are Nematoda , Arthopoda , Hexapoda , and Arachnida .

The active compounds in the compositions according to the invention have potent antimicrobial, fungicidal and insecticidal activity, for example in the fields of crop protection, material protection, veterinary science and animal husbandry, as well as unwanted phytopathogenic fungi and / or microorganisms and / And can be used as a domestic insecticide.

Within the composition according to the invention, the fungicidal compounds are used in the protection of crops, for example Plasmodiophoromycetes , Oomycetes , Chytri-diomycetes , Zygomycetes , Ascomycetes ), Phytopathogenic fungi such as Basidio-mycetes and Deuteromycetes , and / or microorganisms and / or pests.

In the compositions according to the invention, insecticidal compounds can be used for crop protection, for example for the rescue of plant pathogenic insects.

In the composition according to the invention, the live bacteria compounds in crop protection, such as Pseudomonas mono Ada years old child (Pseudomonoadaceae), Li Jovi Asia (Rhizobiaceae), Enterobacter bacteria years old child (Enterobacteriaceae), Corey four bacteria years old child (Corynebacteriaceae) and And can be used to rescue microorganisms such as Streptomycetaceae .

The fungicidal and insecticidal compounds and / or compositions according to the present invention can be used for the curative or prophylactic remedy of phytopathogenic fungi and / or microorganisms and / or pests of plants or crops. Thus, in accordance with a further aspect of the present invention there is provided the use of the fungicides and pesticide compositions according to the present invention, including seeds, plants, fruits of plants, or applying to soils where the plants grow or where they wish to grow plants There is provided a method of healing and prophylactically remedying phytopathogenic fungi and / or microorganisms and / or pests of plants or crops,

All plant and plant parts can be treated according to the invention. A plant is any plant or plant group, such as wild or unwanted wild plants, cultivars (including naturally occurring cultivars), and cultivars (which may or may not be protected by the plant breeder's or plant breeder's rights). Cultivars and plant cultivars may be supplemented or supplemented in one or more biotechnological ways, including transgenic plants, such as haploid, protoplast fusion, random and directed mutagenesis, using molecules or gene markers Which may be obtained by conventional breeding and breeding methods, or by biotechnological and genetic engineering methods.

Plant parts should be understood to mean all ground and underground parts and organs of a plant such as shoots, leaves, flowers, fruit flowers and roots, for example leaves, needles, stems, branches, Flowers, fruits, fruits, seeds, roots, caliber and rhizomes. Crops and nutrition and reproductive material, such as cuttings, calibers, rhizomes, vines and seeds, also belong to the plant parts.

According to the present invention, the expression "plant propagation material" means any plant material that can be used in a nutrition or reproduction reproduction state of a plant. Examples of plant propagation material include cuttings, calibers, rhizomes, vines, seeds, fruit, grains, pods, fruit, stem and seedlings.

The combination / composition according to the invention for combating plant pathogenic fungi and / or microorganisms and / or insects in crop protection comprises an effective but non-phytotoxic amount of the active compounds according to the invention. An "effective but non-phytotoxic amount" means an amount of a formulation according to the invention which, on the one hand, satisfactorily or completely eliminates the fungal disease of the plant, but which does not carry any significant symptoms of phytotoxicity on the crop. The effective amount can generally vary to a broader extent. This amount will depend on a number of factors such as the fungi to be eradicated, the plant, the climatic conditions and the compounds of the formulations according to the invention.

Plants that can be protected by the method of the present invention include major field crops such as maize, soybean, cotton, rapeseed seeds such as Brassica napus (e.g., canola), Brassica rapa Brassica rapa , Brassica juncea (such as mustard) and Brassica carinata , rice, wheat, sugar beet, sorghum, oats, rye, barley, millet, Such as apricot, cherry almond and peach, as well as various fruits and vegetables of the vine plants and various plant classifications such as Rosaceae sp . (For example, pip fruits such as apples and pears, Ribesioidae sp ., Juglandaceae sp. , Betulaceae sp. , Anacardiaceae sp. , Fagaceae sp., And Fagaceae sp. Are the most common fruit species in Korea . ), Moraceae species (Moraceae sp.), species (Oleaceae sp.) in oleic Asia, The tea will Seah species (Actinidaceae sp.), Lauraceae species (Lauraceae sp.), Musaceae species (Musaceae sp.) (For example banana trees and plantations), Rubiaceae species (Rubiaceae sp.) (For example, coffee) Theaceae sp. , Sterculiceae sp. , Rutaceae sp. (Such as lemon, orange and grapefruit); Solanaceae sp. (For example tomatoes, potatoes, peppers, branches, flatlands), Liliaceae sp. , Compositiae sp . (Eg lettuce, Chalk and chicory - including root chicory, flowering lettuce or common chicory, mountain and species ( Umbelliferae sp .) (Eg carrots, parsley, celery and rooted celery), Cucurbitaceae sp . ) (Including cucumber - pickled cucumber, squash, watermelon, calabash and melon), leek species (Alliaceae ap. ) (Eg onions and leeks) Cruciferae sp. , Such as white cabbage, broccoli, cauliflower, brussel sprout, cyanobacterium, cola, radish, horseradish, cabbage, (Leguminosae sp.) (e.g., peanuts, peas and beans - for example includes vine kidney bean and broad bean), Keno Fordyce Asian species (. Chenopodiaceae sp) (e.g. bit, chard, spinach, beetroot), Asteraceae species (Asteraceae sp (Eg sunflower), cruciferous species ( Brassicaceae sp .) (Eg white cabbage, broccoli, cauliflower, brucellal cabbage, cyanobacteria, cola bean, canola, oilseed rape, mustard, horseradish, , Fabacae sp . (For example peanuts and beans), Papilionaceae sp . (For example soybean), Malvaceae (for example, okra) , Asparagaceae (e.g., asparagus); Horticulture and forest crops; As well as genetically modified homologues of these crops.

The treatment method according to the present invention can be used for the treatment of genetically modified organisms (GMO), for example plants or seeds. Genetically modified plants (or transgenic plants) are plants in which heterologous genes are stably integrated into the genome. The expression "heterologous gene" is inherently expressed outside the plant, assembled and introduced into the nucleus, where the chloroplast or mitochondrial genome expresses the target protein or polypeptide, or downgrades other gene (s) present in the plant Refers to a gene that provides new or improved plant characteristics or other properties to the transformed plant by modulating or silencing (e.g., using antisense technology, co-suppression technology, or RNA interference (RNAi) technology) . The heterologous gene located in the genome is also called a transgene. The transgene genes, defined by their specific location in the plant genome, are referred to as transgenic or transgenic events.

Depending on the plant species or plant cultivars, their location and the growing conditions (soil, climate, growth period, nutrients), the treatment according to the invention may also cause an extraordinary ("synergistic") effect. Thus, for example, there is a need to reduce the application rates of active compounds and compositions that can be used in accordance with the present invention and / or to increase the activity spectrum and / or activity, to increase plant growth, to increase resistance to high or low temperatures, Or higher salt tolerance to soil salt content, increased tolerance to growth, ease of harvesting, promotion of maturity, increased yield, greater fruit, greater plant height, more green leaf color, earlier flowering, increased quality and / Higher sugar content in the fruit, better storage stability and / or processability of the harvest product is possible, which exceeds the actual expected effect.

At certain application rates, the combination of active compounds according to the invention may also have a beneficial effect on the plants. They are therefore also suitable for harvesting plant defense systems against undesirable phytopathogenic fungi and / or attacks by microorganisms and / or viruses. This may, for example, be a factor of enhanced activity against fungi, for example, according to the invention, according to the invention. In this regard, the plant-fortified (tolerance-inducing) substance may be a plant-derived fungus and / or a microorganism and / or a virus and / or a virus when the plant is inoculated with unwanted phytopathogenic fungi and / Or a combination of substances or substances capable of stimulating the defense system of the plant in a manner that exhibits a significant degree of tolerance to insect pests. In this case, unwanted phytopathogenic fungi and / or microorganisms and / or viruses should be understood as meaning unwanted phytopathogenic fungi, bacteria and viruses and / or pests. Thus, the substances according to the invention can be used to protect the plant against attack by the aforementioned pathogens within a certain period of time after treatment. The time at which protection is achieved generally ranges from 1 to 10 days, preferably from 1 to 7 days, after treatment of the plant with the active compound.

Plants and plant cultivars which are preferably treated in accordance with the invention include all plants (obtained by breeding and / or biotechnological means) with genetic material which are particularly advantageous for these plants and confer useful traits.

Plant and plant cultivars which are also preferably treated according to the invention are resistant to one or more biological stresses, i.e. the plants are resistant to animal and microbial insects such as nematodes, insects, mites, phytopathogenic fungi, It is more resistant to bacteria, viruses, and / or viroids.

Plants and plant cultivars that may also be treated according to the present invention are plants resistant to one or more abiotic stresses. Abiotic stress conditions include, for example, drought, exposure to cooling temperatures, thermal exposure, osmotic stress, flood, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients Limited availability of nutrients, and shade avoidance.

Plants and plant cultivars that can also be treated according to the present invention are plants characterized by enhanced harvestability. Increased yields in such plants can be achieved, for example, by improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen utilization, enhanced carbon assimilation, improved photosynthesis, And accelerated maturation. Yields can also be adjusted by controlling the flowering rate, flowering regeneration for hybrid seed production, seedling growth, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or pod count, But is not limited to, improved plant architecture including, but not limited to, seed number per seed, seed volume, enhanced seed filling, seed discontinuity reduction, pod dehiscence reduction and lodging resistance. (Under stress and non-stress conditions). Additional yield characteristics include seed composition, for example, carbohydrate content, protein content, oil content and composition, nutritional value, reduction of anti-nutritional compounds, improved processability and better storage stability.

Examples of plants having the above-mentioned characteristics are exemplified in, but not limited to, the following.

crops characteristic GMO References All crops Water use efficiency Y WO 2000/073475 All crops Nitrogen utilization efficiency Y WO1995 / 009911 All crops Nitrogen utilization efficiency Y WO1997 / 030163 All crops Improve photosynthesis Y WO2003 / 000066 Big head Nematode resistance N WO1995 / 020669 Rapeseed Decrease pod opening Y WO2006 / 009649 Big head Aphid resistance N WO2006 / 125065 Lettuce Aphid resistance N WO1997 / 046080 Rapeseed Sclerotinia resistance N WO2006 / 135717 tomato Botrytis resistance N WO2006 / 046861 Lettuce Bremia immunity N US20070022496 potato Erwinia resistance N WO2004 / 049786 cucumber Closterovirus resistance N WO2002 / 022836 pepper Viral resistance N WO2006 / 038794

Plants that can be treated in accordance with the present invention are generally hybrid plants that have already expressed the characteristics of hybrid stress or hybrid growth that results in higher yields, growth, vitality and resistance to biological and abiotic stressors. These plants are generally produced by crossbreeding an inbred male-sterile parent line (mature parent) with other subordinate male-reproductive parental lines (male parent). Hybrid seeds are generally harvested from male sterile plants and sold to growers. Male sterile plants may sometimes be produced by detachment of male flower buds (ie in maize), ie, by mechanical removal of the male reproductive organs (or male flowers), but more generally male sterility is the genetic determinant in plant genomes Results. In this case and especially when the seed is the desired product to be harvested from a hybrid plant, this is typically useful to ensure complete reproductive recovery in a hybrid plant. This can be achieved by ensuring that the male parent has a suitable reproductive recovery gene that can restore male reproductive performance in a hybrid plant containing genetic determinants involved in male sterility. Male sterile genetic determinants can be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) include, for example, Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 And US 6,229,072). However, male sterility genetic determinants may also be located in the nuclear genome. Male sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396, wherein ribonuclease, e.g., barnase, is selectively expressed in the carpet cells of the surgery, for example, . Reproductive performance can then be restored by expression in rubella cells of ribonuclease inhibitors, e. G. Barstar (e.g. WO 91/02069).

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can be treated in accordance with the present invention may be herbicide tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained by selection of plants that contain genetic transformation, or mutations that confer such herbicide tolerance.

Herbicide-tolerant plants are plants that have been made tolerant to, for example, glyphosate-tolerant plants, i.e. herbicide glyphosate or its salts. Plants can be made resistant to glyphosate through different means. For example, a glyphosate-tolerant plant can be obtained by transforming a plant with the gene encoding the enzyme 5-enolpyruvyl chymate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes include the AroA gene (mutation CT7) of Salmonella typhimurium bacteria (Comai et al., Science (1983), 221, 370-371), the Argobacterium sp. (Shah et al., Science (1986), 233, 478 (1987)), the CP4 gene of the Petunia EPSPS (Barry et al., Curr. Topics Plant Physiol -481), tomato EPSPS (Gasser et al., J. Biol. Chem. (1988), 263, 4280-4289) or Eleusine EPSPS (WO 01/66704). It may also be, for example, a mutant EPSPS as described in EP-A 0837944, WO 00/66746, WO 00/66747 or WO 02/26995. The glyphosate-tolerant plant can also be obtained by expressing a gene encoding the glyphosate oxido-reductase enzyme described in U.S. Patent Nos. 5,776,760 and 5,463,175. The glyphosate-tolerant plant may also contain a gene encoding the glyphosate acetyltransferase enzyme described in, for example, WO 02/36782, WO 03/092360, WO 05/012515 and WO 07/024782 Lt; / RTI > The glyphosate-tolerant plant may also be obtained by selecting plants containing a naturally-occurring mutation of the above-mentioned genes, for example, as described in WO 01/024615 or WO 03/013226.

Another herbicide tolerant plant is a herbicide that inhibits enzyme glutamine synthetase, for example, a plant made to be resistant to bialaphos, phosphinotricin or glucosinide. These plants can be obtained by expressing herbicide-decrypting enzymes or inhibitory mutant glutamine synthase enzymes. One such effective detoxifying enzyme is an enzyme that encodes a phosphinotricin acetyltransferase (e. G. , A bar or pat protein from Streptomyces species ). Plants expressing exogenous phosphinotricin acetyltransferase are described, for example, in U.S. Patent Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.

Additional herbicide-tolerant plants are also plants that are engineered to tolerate herbicides that inhibit the enzyme hydroxyphenylpyruvatedioxygenase (HPPD). Hydroxyphenylpyruvate dioxygenase is an enzyme that catalyzes the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants resistant to HPPD-inhibitors include those encoding a naturally occurring HPPD enzyme or a mutant HPPD enzyme, such as those described in WO 96/38567, WO 99/24585 and WO 99/24586 Can be transformed. Resistance to HPPD-inhibitors can also be obtained by transforming a plant with a gene encoding a specific enzyme that allows homogenisation of the plant, despite inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such plants and genes are described in WO 99/34008 and WO 02/36787. Resistance to plants' HPPD inhibitors can also be achieved by transforming the plants into genes encoding the HPPD-resistant enzyme as well as the enzyme encoding prephenate dehydrogenase as described in WO 2004/024928 .

Other additional herbicide tolerant plants are plants that are made resistant to acetolactate synthase (ALS) inhibitors. Known ALS-inhibitors include, for example, sulfonylureas, imidazolinones, triazolopyrimidines, pyrimidinyloxy (thio) benzoates and / or sulfonylaminocarbonyltriazolinone herbicides. Other mutations in ALS enzymes (also known as AcOH hydroxy synthase, also known as AHAS) are described, for example, in Tranel and Wright Weed Science (2002), 50, 700-712) and U.S. Patents 5,605,011, 5,378,824, 5,141,870 And 5,013,659, which are known to impart resistance to other herbicides and herbicide groups. U.S. Patent No. 5,605,011 for the production of sulfonylurea-resistant plants and imidazolinone-resistant plants; 5,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; And 5,378,824; And International Publication WO 1996/33270. Other imidazolinone-resistant plants are also described in, for example, WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376 , WO 2006/024351 and WO 2006/060634. Additional sulfonylurea- and imidazolinone-resistant plants have also been described, for example, in WO 07/024782.

Other plants resistant to imidazolinone and / or sulfonylurea are described, for example, in US Patent 5,084,082 for soybeans, WO 97/41218 for rice, US 5,773,702 for sugarcane and WO 99 / 057965, US Patent 5,198,599 for lettuce, or WO 01/065922 for sunflower, by induction of mutagenesis, selection in cell culture or mutagenesis in the presence of a herbicide .

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can also be treated in accordance with the present invention are insect-resistant transgenic plants, i. E. Plants resistant to attack by certain target insects. Such plants can be obtained by gene selection or plant selection containing mutations that confer such insect resistance.

As used herein, an "insect-resistant transgenic plant" includes any plant that contains at least one transgene containing a coding sequence that encodes the following 1) to 8):

1) Bacillus thuringiensis- derived insecticidal crystal protein or its insecticidal part, for example as described in Crickmore et al. Microbiology and Molecular Biology Reviews, (1998), 62: 807-813), and the Bacillus thuringiensis toxin nomenclature, online (http://www.lifesci.sussex.ac.uk/Home/Neil_ Crickmore / For example, a protein of the Cry protein class Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Aa or Cry3Bb, or an insecticidal portion thereof, which is updated by Crickmore et al. (2005) ; or,

2) a binary protein comprising a crystal protein or part thereof derived from an insecticidal Bacillus thuringiensis in the presence of a second other crystal protein or part thereof derived from Bacillus thuringiensis, for example a Cry34 and a Cry35 crystal protein (Moellenbeck et al., 2001, Nat. Biotechnol., 19: 668-72, Schnepf et al., 2006, Applied Environm Microbiol., 71, 1765-1774); or,

3) a heterologous insecticidal protein comprising parts of other insecticidal crystal proteins derived from Bacillus thuringiensis, for example the protein hybrid of 1) above, or the protein hybrid of 2), for example the maize event MON98034 Produced Cry1A.105 protein (WO 2007/027777); or,

4) to obtain a high degree of insecticidal activity against the target insect species and / or to increase the range of the target insect species affected, and / or due to the changes introduced into the coding DNA during replication or transformation, Any one of the above 1) to 3) wherein 10 amino acids are replaced by other amino acids, for example Cry3Bb1 protein in maize event MON863 or MON88017, or Cry3A protein in maize event MIR604;

5) Salivatory proteins secreted from Bacillus thuringiensis or Bacillus cereus , or its insecticidal part, for example, http://www.lifesci. vegetable insecticidal (VIP) proteins listed in sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, for example the proteins of the VIP3Aa protein family; or,

6) Bivalent toxin consisting of proteins secreted from insecticidal Bacillus thuringiensis or Bacillus cereus in the presence of a second protein secreted from Bacillus thuringiensis or Bacillus cereus, for example, VIP1A and VIP2A proteins (WO 1994 / 21795); or,

7) a hybridoma protein comprising a Bacillus thuringiensis or a portion of another protein secreted from Bacillus cereus, for example a protein hybrid of 1) above or a protein hybrid of 2); or

8) to obtain a high insecticidal activity against the target insect species and / or to expand the range of target insect species affected and / or to introduce into the coding DNA during replication or transformation (still encoding the insecticidal protein) Any one of the above 1) to 3), for example, the VIPAAa protein in the cotton event COT102, wherein some, in particular 1 to 10 amino acids are replaced by other amino acids.

Of course, the insect-resistant transgenic plants used herein also include any plant comprising a combination of genes encoding any one of the abovementioned groups 1-8. In one embodiment, the insect-resistant plants are used to expand the range of target insect species that are affected when different proteins are used for different target insect species, or to insect- Containing a plurality of transgene genes encoding any one of the above-mentioned classes 1 to 8 to delay the occurrence of insect resistance in plants by using different proteins having different modes of action such as binding to the binding site.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can also be treated in accordance with the present invention are resistant to abiotic stress. Such plants can be obtained by gene selection or plant selection containing mutations that confer such stress tolerance. Examples of particularly useful stress tolerant plants include:

a. (PARP) gene in a plant cell or plant as described in WO 00/004173, EP 04077984.5, or EP 06009836.5, as well as a transgenic plant which is capable of reducing the expression and / or activity of the poly (ADP-ribose) polymerase Plants.

b. A plant containing a stress tolerance enhancer gene capable of reducing the expression and / or activity of PARG encoding a plant or plant cell gene, for example, as described in WO 2004/090140.

c. For example, as described in EP 04077624.7, WO 2006/133827 or PCT / EP07 / 002433, nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyltransferase, nicotinamide adenine A plant containing a stress tolerance enhancer transgene encoding a plant-functional enzyme of the nicotinamide adenine dinucleotide salvage synthesis pathway, including a dinucleotide synthase or nicotinamide phospholibosyltransferase.

Plant or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated in accordance with the present invention may be produced by altering the quantity, quality and / or storage stability of the harvest product and / Lt; RTI ID = 0.0 > of:

1) Modified starch is synthesized and its physico-chemical properties, especially amylose content or amylose / amylopectin ratio, branching degree, average chain length, side chain distribution, viscosity behavior, gelation strength, starch grain size and / Transgenic plants that are more suitable for special applications as they are modified compared to starch synthesized in cells or plants. Such transgenic plants for the synthesis of modified starches are described, for example, in EP 0571427, WO 95/04826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188 WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO 99/58688, WO WO 99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01 / 12826, WO 02/101059, WO 03/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619 , WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP 07090009.7, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98 / 20145, WO 99/12950, WO 99/66050, WO 99/53072, US 6734341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO WO 01/98509, WO 2005/002359, US 5824790, US 6013861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026, WO 97/20936 .

2) Transgenic plants that synthesize non-oligosaccharide polymers, or synthesize non-oligosaccharide polymers with altered properties compared to wild-type plants without genetic modification. Examples include plants which produce inulin and levan-type polyfructose, especially as disclosed in EP 0663956, WO 96/01904, WO 96/21523, WO 98/39460 and WO 99/24593 1, 2, 3, 4 or 5 as disclosed in WO 95/31553, US 2002031826, US 6284479, US 5712107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249 Plants producing glucan, plants producing alpha-1, 6-branched alpha-1,4-glucan as disclosed in WO 00/73422, plants in WO 00/47727, EP 06077301.7, US 5,908,975 and EP 0728213 For example, plants that produce altars such as those described in U.

3) Generate hyaluronan as disclosed, for example, in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006/304779 and WO 2005/012529 Transgenic plants.

Plants or plant cultivars (which may be obtained by plant biotechnology methods such as genetic engineering) that can also be treated according to the present invention are plants such as cotton plants with modified fiber properties. Such plants may be obtained by plant selection, including genetic transformation, or mutations conferring the modified fiber properties, and include the following plants:

a) plants such as cotton plants containing the mutated cellulose synthase gene as disclosed in WO 98/000549,

b) plants such as cotton plants containing mutant rsw2 or rsw3 homologous nucleic acids as disclosed in WO 2004/053219,

c) plants such as cotton plants with increased expression of sucrose phosphate synthase as disclosed in WO 01/017333,

d) plants such as cotton plants with increased expression of sucrose synthase as disclosed in WO 02/45485,

e) cotton plants with a plasmo-desmatal gating period altered on the basis of fibroblasts, for example by down-regulation of the fiber-selective < RTI ID = 0.0 > Such as plants,

f) plants, such as cotton plants, for example as disclosed in WO 2006/136351, wherein the reactivity of the fibers is altered through expression of N-acetylglucosamine transferase genes, including nodC and chitin synthase genes.

Plants or plant cultivars (which may be obtained by plant biotechnology methods, such as genetic engineering), which may also be treated in accordance with the present invention, are plants such as oilseed rape or related rapeseed plants with altered oil profile characteristics. Such plants can be obtained by plant selection, including genetic transformation, or mutations conferring the modified oil properties, and include the following plants:

a) plants such as oilseed rape plants which produce oils having high oleic acid content as disclosed in US 5,969,169, US 5,840,946, US 6,323,392 or US 6,063,947,

b) plants such as oilseed rape plants which produce oils having low linoleic acid content as disclosed in US 6,270,828, US 6,169,190 or US 5,965,755,

c) plants such as oilseed rape plants which produce oils with low saturated fatty acid levels as disclosed in US 5,434,283.

Particularly useful transgenic plants that may be treated in accordance with the present invention are those subject to non-regulated item applications, whether or not applications for non-regulated items are still pending in the US Department of Agriculture (USDA) Animal Husbandry Quarantine (APHIS) A transgenic event or a combination of transgenic events. This information can be obtained at any time at APHIS (4700 River Road Riverdale, MD 20737, USA) or, for example, on his Internet site (URL http://www.aphis.usda.gov/brs/not_reg.html). have. As of this application date, the status of non-regulated item applications pending or approved by APHIS is listed in Table B with the following information:

- Application: Application confirmation number. The technical details of the transferee can be found in the individual application documents available from APHIS, for example on the APHIS website, in relation to this application number. These are incorporated herein by reference.

- Extension of application: Based on existing application for extension.

- Agency: The name of the business that submitted the application.

- Regulatory items: related plant species.

- Transgenic phenotype: The property imparted to a plant by a transgenic event.

- Transition event or line: The name (s) of the event (s) for which the non-regulated item was applied (may be indicated as line (s)).

APHIS Documents: A variety of documents that can be requested by APHIS and published by APHIS in connection with the application.

Additional particularly useful plants containing a single transfection event or a combination of transfection events can be found in, for example, databases of various countries or jurisdictions (see, e.g., http://gmoinfo.jrc.it/gmp_browse.aspx and http : //www.agbios.com/dbase.php).

Other particularly useful transgenic plants include those plants that contain a transgene in a locus that is agriculturally neutral or beneficial as described in any of the patent publications listed in Table C.

Examples of plants with the above-mentioned characteristics are shown in Table A in a non-limiting manner.

Particularly useful plants that may be treated in accordance with the present invention are plants containing a single transgenic event or combination of transgenic events, for example, a database of various countries or jurisdictional agencies (see, e.g., http: //gmoinfo.jrc .it / gmp_browse.aspx and http://www.agbios.com/dbase.php).

Particularly useful transgenic plants that can be treated in accordance with the present invention are the plants listed in Table B with their trade names.

Table B

Other particularly useful transgenic plants include plants containing at least one transgene in the agronomically neutral or beneficial position listed in Table C.

Table C2

In a very particularly preferred embodiment, the seeds, plant propagation material, plant or genetically modified plant (the active ingredient expressed by the genetically modified plant corresponds to the line of Tables A, B or C) A method of treating or preventing phytopathogenic fungi and / or microbes and / or pests of plants or crops, including using combinations of (A) and (B) A method for relieving the disease was described.

In a very particularly preferred embodiment, the seeds, plant propagation material, plant or genetically modified plant (the active ingredient expressed by the genetically modified plant corresponds to a line of any of Tables A, B or C) (S) of plants or crops, including the use of combinations of (A) and (B) or of (A) and (B) A method of relief was described.

In another aspect, there is provided a composition comprising a combination according to the present invention. Preferably, the fungicidal and insecticidal compositions comprise agriculturally acceptable additives, solvents, carriers, surfactants or extenders.

According to the present invention, the term "carrier " means a natural or synthetic organic or inorganic compound combined or associated with an active compound (A), a compound (B) and a compound (C) . Thus, the support should preferably be inert, at least agriculturally acceptable. The support may be solid or liquid.

Suitable solid carriers are, for example, ammonium salts and natural rock powders such as kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth and synthetic rock powders such as highly disperse silicas, aluminum oxides and silicates, oil waxes, Solid fertilizers, water, alcohols, preferably butanol, organic solvents, mineral oils and vegetable oils and derivatives thereof.

Suitable solid carriers for granules include, for example, ground granulated or cracked natural rocks such as calcite, marble, pumice, hemastone and dolomite, or synthetic granules of inorganic and organic powders, and paper, sawdust, coconut shells, corncobs, It is a granule of the same organic material.

Suitable liquefied gas diluents or supports are liquids which are gaseous at ambient temperature and atmospheric pressure, such as halohydrocarbons and aerosol propellants such as butane, propane, nitrogen and carbon dioxide.

Tackifiers such as carboxymethylcellulose and natural phosphates such as gum arabic, polyvinyl alcohol and polyvinyl acetate, polymers in the form of granules or latex, or natural phospholipids such as cephalins and lecithins and synthetic phosphatides, Lt; / RTI > Other additives are optionally modified mineral oils or vegetable oils and waxes.

Examples of suitable extender are water, polar and nonpolar organic chemical liquids such as aromatic and non-aromatic hydrocarbons such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes, alcohols and polyols (optionally substituted, etherified and / Such as acetone, cyclohexanone, esters (including fats and oils) and (poly) ethers, unsubstituted and substituted amines, amides, lactams such as N -alkylpyrrolidone ), And lactones, sulfone, and sulfoxide (e.g., dimethylsulfoxide).

If the extender used is water, for example, an organic solvent may also be used as the co-solvent. Suitable liquid solvents are mainly aromatic compounds such as xylene, toluene or alkylnaphthalene; Chlorinated aromatic and chlorinated aliphatic hydrocarbons such as chlorobenzene, chloroethylene or methylene chloride; Aliphatic hydrocarbons such as cyclohexane or paraffins, such as mineral oil fractions, mineral oils and vegetable oils; Alcohols such as butanol or glycol and their ethers and esters; Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone; A strong polar solvent such as dimethylsulfoxide, and water.

The composition according to the invention may also comprise further components. In particular, the composition may further comprise a surfactant. Surfactants may be ionic or nonionic emulsifiers, dispersants or wetting agents or mixtures of these surfactants. Examples of these surfactants include polyacrylates, lignosulfonates, phenol sulfonates or naphthalenesulfonates, polycondensates of ethylene oxide with fatty alcohols or fatty acids or fatty amines, substituted phenols (especially alkyl phenols or aryl phenols ), Sulfosuccinic acid ester salts, taurine derivatives (especially alkyl taurates), phosphoric esters of polyethoxylated alcohols or phenols, fatty esters of polyols, and derivatives of compounds containing sulfates, sulfonates and phosphate functional groups, Alkylaryl polyglycol ethers, alkyl sulfonates, alkyl sulfates, aryl sulfonates, protein hydrolysates, lignosulfite waste solutions and methylcellulose. The presence of at least one surfactant is essential if the active compound and / or inert support is insoluble in water and the application medium occurs in water. Preferably, the amount of surfactant may be from 5 to 40% by weight of the composition.

Suitable emulsifiers and / or foam formers are, for example, nonionic and anionic emulsifiers such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, suitable dispersing agents include nonionic and / or ionic surfactants, POE and / or POE esters, alkyl-aryl and / or POP or POE ethers, fatty and / or POP-POE adducts, POE and / or POP polyol derivatives, POE and / Or POP / sorbitan or sugar adduct, alkyl or aryl sulfate, sulfonate and phosphate or the corresponding PO ether adduct. Suitable oligomers or polymers are also based on the combination of, for example, vinyl monomers, acrylic acid, EO and / or PO alone or, for example, (poly-) alcohol or (poly) -amine. Lignin and its sulfonic acid derivatives, simple and modified cellulose, aromatic and / or aliphatic sulfonic acids, and adducts of these with formaldehyde. Suitable dispersants are, for example, lignocylite waste and methylcellulose.

Organic pigments, such as iron oxide, manganese, boron, copper, cobalt, molybdenum and zinc, and inorganic pigments such as iron oxide, titanium oxide and ferrocyan blue, and organic pigments such as alizarin dyes, azo dyes and metal phthalocyanine dyes, The same micronutrient can be used.

Optionally, further additional components such as, for example, protective colloids, tackifiers, thickeners, thixotropic substances, penetrants, stabilizers, sequestrants, etc. may also be present. More generally, the active compound may be combined with any solid or liquid additive used according to the general techniques.

In general, the composition according to the invention may contain from 0.05 to 99% by weight, preferably from 1 to 70% by weight, particularly preferably from 10 to 50% by weight, of the active compound.

The formulations or compositions according to the present invention may be used as such, in the form of preparations thereof, or in the use forms prepared therefrom, such as aerosol dispensers, capsule suspensions, cold concentrates, hotmelt concentrates, encapsulated granules, Liquid concentrate, ready-to-use solution, dustable powder, emulsifiable concentrate, oil-in-water emulsion, water-in-oil emulsion, large granule, fine granule, oil dispersible powder, oil Soluble concentrates, oil-miscible liquids, foams, pastes, seeds coated with pesticides, suspended concentrates (flowable concentrates), suspensions - emulsions - concentrates, soluble concentrates, suspensions, soluble powders, granules, water soluble granules Or microencapsulation and ULV-cold and warm-free agents, gases (under pressure), inhalants, water-soluble powders for seed treatment, natural and synthetic materials into which active compounds are injected, seed polymeric materials and jackets, Plant rodlets, dry seed treatment powders, seed treatment solutions, ultra low volume (ULV) liquids, ultra-volumetric suspensions, water-dispersible granules or tablets, for slurry treatment Water-dispersible powder and the like.

These preparations can be prepared by known methods, for example by mixing the active compound or a combination of active compounds with customary additives such as conventional extenders and solvents or diluents, emulsifiers, dispersants and / or binders or fixatives, wetting agents, , Optionally with a drying agent and a UV stabilizer, a colorant, a pigment, a defoamer, an antiseptic, a secondary thickener, a tackifier, gibberellin, water and further processing aids.

These compositions include not only compositions that are applied immediately to plants or seeds using suitable devices such as spraying or dustering devices, but also commercial concentrated compositions that must be diluted prior to application to crops.

The remediation of phytopathogenic fungi and / or microorganisms and / or insects that damage plants after germination is accomplished primarily by treating the soil and plant parts of the plant with a crop protection agent. Efforts have been made to reduce the application of active compounds due to concerns that crop protection agents can damage the environment and human and animal health.

The combination of active compounds according to the invention may be formulated as a mixture with other active compounds such as insecticides, attractants, sterilizing agents, bactericides, acaricides, nematicides, fungicides, growth regulators, herbicides, And may be used in the form of a preparation made from these preparations.

Treatment of plant and plant parts with a combination of active compounds according to the present invention may be carried out by conventional methods, for example by spraying, drip irrigation, spraying, evaporation, spraying, spraying, dusting, In the case of seeds, in the case of seeds, the seeds for processing seeds, the seed treatment solution, the water-soluble powder for seed treatment, the aqueous powder for slurry treatment, the encrusting, the drying treatment, the slurry treatment, Directly or by multiple coatings, or by acting on its environment, habitat or storage space. It is also possible to apply the active compound by a microfluidic method, or to inject the active compound preparation or the active compound itself into the soil.

The rate of application of the combination depends on, for example, the mode of use, the type of crop, the particular active compound in the formulation, the type of plant propagation material (as the case may be) Insect pest control), and can be determined by testing.

The process according to the invention also provides the use of the compounds (A) and (B) simultaneously, separately or in a sequential manner.

The dose / application rate of the active compound usually applied in the process according to the invention is

In the case of leaf treatment, the compound (A) is used in an amount of 0.1 to 10,000 g / ha, preferably 10 to 1,000 g / ha, more preferably 50 to 300 g / ha; 0.1 to 10,000 g / ha of compound (B), preferably 10 to 1,000 g / ha, more preferably 50 to 300 g / ha; The amount of the compound (C) is in the range of 0.1 to 10,000 g / ha, preferably 10 to 1,000 g / ha, more preferably 50 to 300 g / ha (in the case of stationary or spot application, Reduction possible);

In the case of seed treatment, the compound (A) is used in an amount of 2 to 200 g per 100 kg of seed, preferably 3 to 150 g per 100 kg of seed and 2 to 200 g per 100 kg of seed, 3 to 150 grams per 100 kilograms, compound (C) 2 to 200 grams per 100 kilograms of seed, preferably 3 to 150 grams per 100 kilograms of seed;

In the case of soil treatment, 0.1 to 10,000 g / ha, preferably 1 to 5,000 g / ha of compound (A), 0.1 to 10,000 g / ha, preferably 1 to 5,000 g / C) 0.1 to 10,000 g / ha, preferably 1 to 5,000 g / ha.

The dosages presented herein are given to illustrate the method according to the present invention. Those skilled in the art will know in particular how to determine the application amount depending on the plant or crop characteristics to be treated.

The formulations according to the invention can be used to protect plants from pests and / or phytopathogenic fungi and / or microorganisms and / or insects for a certain period of time after treatment. The protection period may range from 1 to 28 days, preferably from 1 to 14 days, or up to 200 days after treatment of the plant propagation material, after the plants have been treated with the combination.

The treatment methods according to the present invention may be useful for the treatment of seeds, seedlings or transplanted seedlings and plants or grafted plants as well as treatment of propagation material such as tubers or rhizomes. The treatment method may also be useful in the treatment of roots. The method of treatment according to the present invention may also be useful for treating surface areas of plants such as the body, stem or sack, leaf, flower and fruit of the relevant plant.

Another aspect of the present invention is the use of a combination of a synergistic effective amount of a compound (A), a compound (B) and a compound (C) in a natural substance of vegetable or animal origin or a processed form thereof taken in the natural life- Is a method for protecting natural substances of the plant or animal origin or a processed form thereof.

A preferred embodiment of the present invention comprises applying a synergistic effective amount of a compound (A), a compound (B) and a compound (C) to a natural substance of plant origin or a processed form thereof taken in the natural life cycle, It is a method of protecting the natural substance of origin or its processed form.

Another preferred embodiment of the present invention is a composition comprising a synergistically effective amount of a compound (A), a compound (B) and a compound (C) in a processed form of fruits, preferably fruits, Quot;), < / RTI > to protect natural materials of the plant origin or their processed forms.

The present invention includes a process for simultaneously treating seed with a compound (A), a compound (B) and a compound (C). The present invention further includes a method of separately treating the seed with the compound (A), the compound (B) and the compound (C).

The present invention also encompasses seed treated with the compound (A), the compound (B) and the compound (C) simultaneously. The present invention also includes seeds treated separately with the compound (A), the compound (B) and the compound (C). In the latter seeds, the active ingredient may be applied as an individual layer. These layers may optionally be separated into additional layers which may or may not contain active ingredients.

The formulations and / or compositions of the present invention are particularly suitable for treating seeds. Most crop damage caused by insect pests and / or phytopathogenic fungi and / or microorganisms and / or insects is triggered during seed storage and after seed sowing, during plant germination and after seed germination. This is particularly important because the roots and buds of growing plants are particularly susceptible and even the entire plant can tolerate some damage. Thus, it is of particular interest to protect seeds and germplasm using appropriate formulations.

It has long been known to treat seeds of plants to relieve pests and / or phytopathogenic fungi and / or microorganisms and / or insects and is an ongoing improvement task. However, the seed treatment has a series of problems that are difficult to solve in a satisfactory manner. It is therefore desirable to develop methods of protecting seeds and germination plants that do not require further application of crop protection agents after sowing or after plant germination. The amount of active compound applied is optimized in such a way as to protect the seed and germination plant from invasion of insect pests and / or phytopathogenic fungi and / or microorganisms and / or pests without the active compound being applied to the plant itself It is also desired. In particular, seed treatment methods should also take into account the fungicides and insecticidal properties of transgenic plants in order to optimally protect seeds and germination plants by minimizing the use of crop protection agents.

Thus, the present invention is also particularly directed to a method for treating seeds and germplasm from insect and / or phytopathogenic fungi and / or microbial and / or insect infestation by treating the seeds with the inventive combination / composition. The present invention also relates to the use of the formulations / compositions of the present invention for treating seeds to protect seeds and germination plants against pests and / or phytopathogenic fungi and / or microorganisms and / or insects. The present invention also relates to seeds treated with the formulations / compositions of the present invention to be protected from insect pests and / or phytopathogenic fungi and / or microorganisms and / or insects.

One advantage of the present invention is that, due to the particular systemicity of the formulations / compositions of the present invention, the treatment of the seeds with these active formulations / compositions can be used not only from the insect and / or phytopathogenic fungi and / or microorganisms and / It also protects plants. Accordingly, it is not necessary to directly treat crops at the time of sowing or immediately thereafter.

A further advantage is that the fungicidal and insecticidal activity of the formulations / compositions of the present invention increases synergistically relative to the individual active compounds, both of which are higher than the sum of the activities of the active compounds applied individually. Thereby, the amount of the active compound applied can be optimized.

It is contemplated that the mixtures of the present invention are particularly useful in transformed seeds so that plants germinated from the seeds can express proteins against pests and / or phytopathogenic fungi and / or microorganisms and / or insects. By treating the seed with the formulation of the present invention, for example, the expression of the insecticide protein can be used to relieve specific insect pests and / or phytopathogenic fungi and / or microorganisms and / or insects and, surprisingly, Lt; RTI ID = 0.0 > synergistic < / RTI >

The formulations of the present invention are suitable for protecting seeds of any plant varieties of any type previously described for use in agriculture, greenhouses, forestry, furrowing, horticulture or vineyards. In particular, it may be used in the production of cereals such as wheat, barley, rye, lime, millet, oats, rice, corn, cotton, soybean, potato, sunflower, ), Peanuts, canola, oilseeds, poppies, olives, coconut, cacao, sorghum or tobacco. The formulations / compositions of the present invention are also suitable for treating seeds of previously described fruit plants and vegetables (e.g., tomatoes, cucumbers, onions and lettuce), grasses, turf and ornamental plants. Seed treatment of wheat, barley, rye, lime, oats, corn, rice, soybeans, cotton, canola and oil seeds is particularly important.

As mentioned above, it is also particularly important to treat the transformed seeds with the formulations / compositions of the present invention. Which is applied to the seed of a plant comprising at least one heterologous gene capable of controlling the expression of a polypeptide having a specific insecticidal activity. In this connection, the heterologous gene in transgenic seed Bacillus (Bacillus), separation tank emptying (Rhizobium), Pseudomonas (Pseudomonas), theta Liao (Serratia), Trichoderma (Tri-choderma), Clavinova bakteo (Clavibacter), glow mousse (Glomus ) Or Glio-cladium . ≪ / RTI > The present invention is particularly suitable for the treatment of transgenic seeds in which at least one heterologous gene is derived from Bacillus sp. And whose gene product exhibits activity against European light moth moths and / or corn root worms. Particularly preferred is a heterologous gene derived from Bacillus thuringiensis .

In the context of the present invention, the formulation / composition of the present invention is applied to the seed, alone or in a suitable formulation. Preferably, the seeds are treated in a state that is sufficiently stable to avoid any damage. Generally, seeds can be processed at any point between harvest and sowing. Usually, the seed used is separated from the plant and does not contain plant spadix, bark, stem, pod, fur or pulp. It is possible to use seeds that have been harvested, washed, or dried to a moisture content of less than 15% by weight. On the other hand, it is also possible to use dried seeds after drying, for example, after treatment with water.

In general, the amount of the formulation / composition of the present invention and / or the amount of the additional additive applied to the seed during seed treatment should be such that the seed germination is not damaged or the resulting plant is selected so as not to be harmed. This should be borne in mind, among other things, when it is an active compound that can have a phytotoxic action at a certain application rate.

The formulations / compositions of the present invention may be applied directly, i.e. without diluting without additional ingredients. In general, it is preferred that the formulation / composition of the present invention is applied to seeds in the form of a suitable preparation. Suitable formulations and seed treatment methods are known to those skilled in the art and are described, for example, in US 4,272,417 A, US 4,245,432 A, US 4,808,430 A, US 5,876,739 A, US 2003/0176428 Al, WO 2002/080675 Al, WO 2002/028186 A2.

Formulations and compositions of active compounds that may be used in accordance with the present invention may be converted into conventional seed dressing formulations and ULV formulations, such as solutions, emulsions, suspensions, powders, foams, slurries or other seed coating materials.

These formulations can be prepared by mixing the active compound or a combination of active compounds with conventional additives such as conventional extenders and solvents or diluents, colorants, wetting agents, dispersants, emulsifiers, defoamers, preservatives, secondary thickeners, tackifiers, And mixed in a known manner.

Suitable colorants that may be present in the seed dressing formulations of the present invention include all colorants customary for this purpose. Both water-soluble pigments and water-soluble dyes can be used. Rhodamine B, C.I. Pigment Red 112 and C.I. Colorants known under the name Solvent Red 1 may be mentioned by way of example.

Suitable wetting agents that may be present in the seed dressing formulations of the present invention include any material that promotes wetting that is conventional in the formulation of the active agent. Alkylnaphthalene-sulfonates such as diisopropyl- or diisobutylnaphthalene-sulfonate may preferably be used.

Suitable dispersing and / or emulsifying agents which may be present in the seed dressing formulations of the present invention include all nonionic, anionic and cationic dispersing agents conventional in the formulation of pesticidal active materials, as described above.

Suitable antifoam agents which may be present in the seed dressing formulations of the present invention include all antifoam agents conventional in the formulation of agrochemical active agents. Silicone defoamer and magnesium stearate may preferably be used.

Suitable preservatives that may be present in the seed dressing formulations of the present invention are all materials that can be used for this purpose in pesticide compositions. Dichlorophenes and benzyl alcohol hemifors may be mentioned by way of example.

Suitable secondary thickeners that may be present in the seed dressing formulations of the present invention are all materials that can be used for this purpose in the pesticide composition. Cellulose derivatives, acrylic acid derivatives, xanthan, modified clays and highly dispersed silicas.

Suitable tackifiers that may be present in the seed dressing formulations of the present invention are all conventional binders that can be used in seed dressing. Polyvinyl pyrrolidone, polyvinyl acetate, polyvinyl alcohol and tiros may be mentioned as preferred examples.

Suitable gibberellins that may be present in the seed dressing formulations of the present invention preferably include gibberellins A1, A3 (= gibberellic acid), A4, and A7, particularly preferably gibberellin A3 (= gibberellic acid). Gibberellins of formula (II) are known, and the name gibberellin is described in R. Wegler "Chemie der Pflanzen-schutz- and Schaedlingsbekaempfungsmittel", Volume 2, Springer Verlag, Berlin-Heidelberg-New York, 1970, pages 401-412.

Suitable seed dressing formulations that can be used in accordance with the present invention, or a mixing apparatus suitable for treating seeds with formulations made by adding water thereto, include any apparatus that can be commonly used for dressing. A specific procedure employed in dressing is to introduce the seeds into the mixer, add the desired amount of seed dressing preparation intact or previously diluted with water, and then perform the mixture until uniformly distributed on the seed . Optionally, a drying process may follow.

The materials of the present invention can be used to protect industrial materials from being infected and destroyed by unwanted fungi and / or microorganisms in protecting materials.

Industrial materials are to be understood as meaning non-living materials manufactured for engineering purposes. Industrial materials which are intended to be protected by the active compounds according to the invention, for example from changes or destruction by microorganisms, can be used as adhesives, glue, paper, cardboard, textile, carpet, leather, wood, paint, plastic products, And other substances that can be infected or destroyed by microorganisms. Included within the scope of the protected material may also be mentioned a part of the production facility, for example a cooling water circuit, which may be adversely affected by the fungi and / or the growth of microorganisms. Industrial materials which may be mentioned as being preferred for the purposes of the present invention are adhesives, glue, paper, cardboard, leather, wood, paint, cold lubricants and heat transfer fluids, particularly preferably wood.

The formulations according to the invention can prevent adverse effects such as decay, corrosion, discoloration, discoloration or mold formation.

The method according to the invention may also be used in the field of protecting stored articles from attack by fungi and microorganisms. According to the present invention, a storage article is to be understood as meaning natural substances of vegetable or animal origin and processing forms thereof, from which long-term protection is desired and taken from the natural life cycle. Such as plants, or plant parts, such as, for example, stems, leaves, tubers, seeds after being harvested, freshly harvested, or (pre) dried, moistened, subdivided, ground, crushed, pressed or roasted , Fruits, and grains can be protected. The storage article also includes finished wood, such as unprocessed wood, such as wood, telephone poles and barriers, or objects made of wood or furniture. Storage items of animal origin include, for example, untreated hide, tanned leather, fur and fur. The combination according to the invention can prevent adverse effects such as decay, discoloration or mold formation. Preferably, the term "storage article" shall be understood to mean fruit and its processed forms, such as natural materials of plant origin and their processed forms, more preferably fruit, nuclease, light fruit and citrus fruit and their processed forms .

In another preferred embodiment of the present invention, "storage article" should be understood as meaning wood. The fungicidal formulations or compositions according to the present invention may also be used in fungal diseases which are susceptible to proliferation on or in the wood. The term "wood" refers to all types of wood, and all architectural processing forms of such wood, such as solid wood, high density wood, glues and plywood. The method of treating wood according to the invention consists primarily of contacting one or more compounds according to the invention or of the composition according to the invention, for example by direct application, spraying, dipping, Other suitable means are included.

The following diseases of plants or crops which may be alleviated by the process according to the invention may be mentioned:

Diseases caused by centromeric pathogens, such as:

For example, Blumeria disease caused by Blumeria graminis ;

For example, grape Podosphaera disease caused by Podosphaera leucotricha ;

For example, Sphaerotheca disease due to Sphaerotheca fuliginea ;

For example, unsi Cronulla Neka Torr unsi Cronulla (Uncinula) due to (Uncinula necator) disease;

Rust, for example:

For example, Gymnosporangium disease due to Gymnosporangium sabinae ;

Hemileia disease due to, for example, Hemileia vastatrix ;

For example Phakopsora disease due to Phakopsora pachyrhizi or Phakopsora meibomiae ;

For example, Puccinia recondita , Puccinia disease due to Puccinia triticina ;

Uromyces disease caused by, for example, Uromyces appendiculatus ;

Oomycete diseases, such as:

For example, Bremia disease due to Bremia lactucae ;

For example, Ferro Ferro North North Fora Fora Fish (Peronospora) diseases caused by the (Peronospora pisi), or Perot North Fora Brassica (Peronospora brassicae);

For example, Phytophthora disease caused by Phytophthora infestans ;

Plasmopara disease due to, for example, Plasmopara viticola ;

For example, Pseudoperonospora disease due to Pseudoperonospora humuli or Pseudoperonospora cubensis ;

For example, Pythium disease caused by Pythium ultimum ;

Spotty, black flea and lamellar fleas, such as:

Alternaria disease due to, for example, Alternaria solani ;

For example, Cercospora disease due to Cercospora beticola ;

For example, Cladiosporium disease caused by Cladiosporium cucumerinum ;

For example, Cochliobolus disease due to Cochliobolus sativus ( Drechslera , homozygous Helminthosporium );

For example, Colletotrichum disease caused by Colletotrichum lindemuthanium ;

For example, Cycloconium disease caused by Cycloconium oleaginum ;

Diaporthe ' s disease caused by Diaporthe citri ;

For example, Elsinoe disease caused by Elsinoe fawcettii ;

For example, Gloeosporium disease caused by Gloeosporium laeticolor ;

For example, Glomerella disease caused by Glomerella cingulata ;

For example, Guignardia disease caused by Guignardia bidwelli ;

Leptosphaeria disease caused by, for example, Leptosphaeria maculans ;

Magnaporthe ' s disease caused by, for example, Magnaporthe grisea ;

For example, Mycosphaerella disease caused by Mycosphaerella graminicola and Mycosphaerella fijiensis ;

For example, Phaeosphaeria disease caused by Phaeosphaeria nodorum ;

For example, Pyrenophora disease caused by Pyrenophora teres ;

For example, Ramularia disease due to Ramularia collo-cygni ;

For example, Rhynchosporium disease due to Rhynchosporium secalis ;

For example, Septoria disease due to Septoria apii ;

For example, Typhula disease caused by Typhula incarnata ;

For example, Venturia disease caused by Venturia inaequalis ;

Root and stem diseases, such as:

Corticium disease due to, for example, Corticium graminearum ;

For example, Fusarium ' s disease caused by Fusarium oxysporum ;

For example, only due to no Mai process gras mini bus (Gaeumannomyces graminis), only gaeum gaeum no Mai access (Gaeumannomyces) disease;

For example, Rhizoctonia disease caused by Rhizoctonia solani ;

For example, an Orculumma culla ( Tafesi ) disease caused by Oculimacula tapesia acuformis ;

For example, Thielaviopsis disease due to Thielaviopsis basicola ;

Ears and cones including corn, and conidia, for example:

Alternaria disease due to, for example, Alternaria spp .;

For example, Aspergillus disease caused by Aspergillus flavus ;

For example, Cladosporium disease caused by Cladosporium Cladosporioides ;

For example, Claviceps disease caused by Claviceps purpurea ;

For example, Fusarium cool morum Fusarium (Fusarium) diseases caused by (Fusarium culmorum);

For example, Gibberella disease caused by Gibberella zeae ;

For example, Monographella disease caused by Monographella nivalis ;

Diffuse bottles and flashed bottles, such as:

For example, Sphacelotheca disease caused by Sphacelotheca reiliana ;

For example, Tilletia disease caused by Tilletia caries ;

For example, Urocystis disease caused by Urocystis occulta ;

For example, Ustilago disease caused by Ustilago nuda ;

Fruit rot and fungal diseases such as:

For example, Aspergillus disease caused by Aspergillus flavus ;

Botrytis disease due to, for example, Botrytis cinerea ;

For example, Penicillium expansum and < RTI ID = 0.0 > Penicillium disease due to Penicillium purpurogenum;

For example, Sclerotinia disease caused by Sclerotinia sclerotiorum ;

For example, Verticilium disease due to the Verticilium alboatrum ;

Seed and soil propagation Corruption, fungi, wilt, rot and melancholia:

For example, Alternaria species due to Alternaria brassicicola ;

For example, Aphanomyces species due to Aphanomyces euteiches ;

For example, Ascochyta species caused by Ascochyta lentis ;

For example, Aspergillus species due to Aspergillus flavus ;

For example, Cladosporium species due to Cladosporium herbarum ;

For example, Cochliobolus species ( Drechslera , Bipolaris isotype: Helminthosporium ) due to Cochliobolus sativus ;

For example, the collation Sat tree dancing (Colletotrichum) species due to Collet sat tree dancing kokko des (Colletotrichum coccodes);

For example, Fusarium (Fusarium) caused by Fusarium species cool morum (Fusarium culmorum);

For example, Gibberella species due to Gibberella zeae ;

For example, a mark or the breech (Macrophomina) species due to the macro and breech Pace olrina (Macropomina phaseolina);

Monographella species due to, for example, Monographella nivalis ;

For example, the petticoat room Solarium (Penicillium) species due to the petticoat room Solarium X pansum (Penicillium expansum);

For example, Phoma species due to Phoma lingam ;

For example, the fabric material's very heavily's fabric (Phomopsis) due to (Phomopsis sojae) species;

For example, a Phytophthora species caused by Phytophthora cactorum ;

For example, Pyrenophora species due to Pyrenophora graminea ;

For example, Pyricularia species due to Pyricularia oryzae ;

For example, Pythium species due to Pythium ultimum ;

For example, Rhizoctonia species due to Rhizoctonia solani ;

Rhizopus species, for example, from Rhizopus oryzae ;

For example, Sclerotium species due to Sclerotium rolfsii ;

For example, the Septoria species due to Septoria nodorum ;

For example, typhula species caused by Typhula incarnata ;

For example, Verticillium species due to Verticillium dahliae ;

Corruption, broomstick and leaf blight, such as:

Nectria disease caused by, for example, Nectria galligena ;

Blight, for example:

For example, Monilinia disease due to Monilinia laxa ;

Leaf curvaceous leaf or leaf curl, including fruit flower and flower varieties, for example:

For example, Taphrina disease due to Taphrina deformans ;

A debilitating bottle of wood plant, for example:

For example, L monitor Ella Cloud Mai doses Fora (Phaemoniella clamydospora), par core Crescent monitor help know Leo pilrum eseuka (Esca) diseases caused by (Phaeoacremonium aleophilum) and breech tipo Ria Mediterraneo Nea (Fomitiporia mediterranea);

Flowers and seed diseases, such as:

Botrytis disease due to Botrytis cinerea ;

Tuberous diseases, such as:

For example, Rhizoctonia disease caused by Rhizoctonia solani .

For example, the Hell Minto Sports Solarium solani (Helminthosporium solani) Hell Minto Sports Leeum (Helminthosporium) diseases caused by.

For example, the following diseases caused by bacterial pathogens:

Xanthomonas Species such as Xanthomonas campestris pv. Duckwood ( Xanthomonas campestris pv. Oryzae ) ;

Pseudomonas (Pseudomonas) Species such as Pseudomonas sp. Pseudomonas syringae pv. Lachrymans and the like;

Erwinia Species such as Erwinia amylovora .

The following soybean diseases can preferably be controlled with the compounds according to the invention:

For example fungal diseases on leaves, upper stems, pods and seeds by:

Atlant tenuissima , anthracnose ( Colletotrichum gloeosporoides dematium var. Truncatum ), Septoria glycines , Cercospora kikuchii , Coleospora leaf blight (Choanephora infundibulifera trispora (Syn.) ), Doc tulrioh Fora leaf blight (Dactuliophora glycines), mildew (Peronospora manshurica), Dre large sled La blight (Drechslera glycini), people bottle leaf spot (Cercospora sojina), rules on repto spa Lena leaf spot (Leptosphaerulina trifolii), Pillows tikka leaf spot (Phyllosticta sojaecola), pod stem blight (Phomopsis sojae), mildew (Microsphaera diffusa), the Pierre noka other leaf spot (Pyrenochaeta glycines), Li Estonian air, leaves, branches Rhizoctonia solani , Phakopsora pachyrhizi , Phakopsora meibomiae , Sphaceloma glycines , Stemphylium botryosum , Cory nespora cassiicola ) etc .;

Fungal diseases on roots and stem bases, for example:

Black Root Rot (Calonectria crotalariae), anthrax (Macrophomina phaseolina), Fusarium wilt or fadeth disease, Root Rot and pod rot and Yun Half bottle (Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti), Miko repto display Coos Root Rot (Mycoleptodiscus terrestris) , Neocosmopspora vasinfecta , Diaporthe phaseolorum , Diaporthe phaseolorum var caulivora , Phytophthora megasperma , Phialophora gregata , Pityrum rot ( Phytophthora spp . Rhizoctonia solani , Sclerotinia sclerotiorum , Sclerotinia rolfsii , Scutellaria spp. , Staphylococcus aureus , Staphylococcus aureus , Staphylococcus aureus , Pythium aphanidermatum , Pythium irregulare , Pythium debaryanum , Pythium myriotylum , Pythium ultimum , Thielaviopsis basicola .

The combinations / compositions of the active compounds according to the invention are useful for the treatment of fungal diseases such as mycosis, skin diseases, pycnidosis and candidiasis or for the treatment of humans or animals from diseases caused by Aspergillus species such as Aspergillus fumigatus It may also be used for the preparation of a medicament for the treatment of an adverse or protective effect.

In addition, the combination / composition of the active compound according to the present invention is excellent in plant tolerance, has toxicity favorable to warm-blooded animals, is excellent in environment-friendliness, protects plants and plant organs, increases yields, And is particularly suitable for rescuing animal pests, especially insects, arachnids, intestinal parasites, nematodes and mollusks, which are encountered in the fields of agriculture, horticulture, animal husbandry, forestry, gardens, leisure facilities, . They may preferably also be used as plant protection agents. They are active for all stages or some stages of normal susceptible and resistant species and development. The above-mentioned pests include the following:

The (Anoplura) neck (Phthiraptera), for example, Tamar Linea species (Damalinia spp.), Under Mato blood Taunus species (Haematopinus spp.), Reno By the tooth species (Linognathus spp.), Phedi cool loose species Pediculus (spp. ) And Trichodectes spp .

Spiders (Arachnida) steel, for example, aka loose Shiro (Acarus siro), ahseriah shell Doni (Aceria sheldoni), ahkul rope's species (Aculops spp.), Ahkul loose species (Aculus spp.), Cancer Bulletin Mama species (Amblyo Bleobia praetiosa , Coriotheops spp. ), Arthas spp ., Boophilus spp ., Brevipalpus spp ., Bryobia praetiosa , Chorioptes spp. , Dermanyssus gallinae , Eotetranychus spp. , Epitrimerus pyri , Eutetranychus spp. , Eriophyces spp. Such as Eriophyes spp. , Hemitarsonemus spp ., Hyalomma spp ., Ixodes spp ., Latrodectus mactans , Metatetra , Metatetranychus spp. , Oligonychus spp ., Ornithodoros s. pp.), par Noni Syracuse species (Panonychus spp.), Philo Coptic doubles Olay Bora (Phyllocoptruta oleivora), poly digging tar Sone moose La Tooth (Polyphagotarsonemus latus), peuso rope test species (Psoroptes spp.), Lippi three Palouse species Such as Rhipicephalus spp ., Rhizoglyphus spp. , Sarcoptes spp ., Scorpio maurus , Stenotarsonemus spp ., Tarsonia spp . Tarsonemus spp ., Tetranychus spp ., And Vasates lycopersici .

The Bivalva River, for example Dreissena spp .

Chilopoda necks, for example Geophilus spp . And Scutigera spec .

Coleoptera sp. , Such as Acanthoscelides obtectus , Adoretus spp ., Agelastica alni , Agriotes spp ., And the like. Amphimallon solstitialis , Anobium punctatum , Anoplophora spp ., Anthonomus spp ., Anthrenus spp ., Apo sp. But are not limited to, Apogonia spp ., Atomaria spp ., Attagenus spp ., Bruchidius obtectus , Bruchus spp . (For example, Ceuthorrhynchus spp .), Cleonus mendicus , Conoderus spp ., Cosmopolites spp ., Costelytra zealandica , ( Curculio spp .), Creptorinkus la party Cryptorhynchus lapathi , Dermestes spp ., Diabrotica spp. , Epilachna spp ., Faustinus cubae , Gibium furosloides ( Gibbium psylloides , Heteronychus arator , Hylamorpha elegans , Hylotrupes bajulus , Hypera postica , Hypothenemus spp, , Lachnosterna consanguinea , Leptinotarsa decemlineata , Lissorhoptus oryzophilus , Lixus spp ., Ricotus spp ., Lactobacillus spp . The present invention relates to a method for the treatment of Lyctus spp ., Meligethes aeneus , Melolontha melolontha , Migdolus spp ., Monochamus spp . Naupactus xa Nryptus hololeucus , Oryctes rhinoceros , Oryzaephilus surinamensis , Otiorrhynchus sulcatus , Oxysetonia , and the like. The present invention relates to a method for the treatment and / or prophylaxis of a disease or condition selected from the group consisting of Oxycetonia jucunda , Phaedon cochleariae , Phyllophaga spp ., Popillia japonica , Premnotrypes spp . For example, Psylliodes chrysocephala , Ptinus spp ., Rhizobius ventralis , Rhizopertha dominica , Sitophilus spp ., Sphenophorus spp . Sphenophorus spp ., Sternechus spp ., Symphyletes spp ., Tenebrio molitor , Tribolium spp ., Trogoderma spp . spp .), Tychius spp ., Xylotrechus spp ., And Zabrus spp .).

Collembola neck, for example Onychiurus armatus .

Dermaptera neck, for example Forficula auricularia .

Millipedes (Diplopoda) tree, for example Blast niul loose obtain Tula tooth (Blaniulus guttulatus).

Diptera spp ., Such as Aedes spp ., Anopheles spp ., Bibio hortulanus , Calliphora erythrocephala , Ceratitiscopy, Tata (Ceratitis capitata), Cri small lost species (Chrysomyia spp.), co-Clo Mia species (Cochliomyia spp.), a via not Trojan myrtle in cor dill (Cordylobia anthropophaga), Culex species (Culex spp.), Pico terephthalate Brassica species (Cuterebra spp.), the Syracuse oleic ah (Dacus oleae), der Mato via hoe varnish (Dermatobia hominis), draw small pillars species (Drosophila spp.), plates California species (Fannia spp.), as Gasthof Peel Such as Gastrophilus spp ., Hylemyia spp ., Hyppobosca spp ., Hypoderma spp ., Liriomyza spp ., Lucilia spp . spp.), museuka species Musca (spp.), four species grow (Nezara spp.), OS Oestrus spp (Truth species) come La frit (Oscinella frit), pego Mia Rio ski amino (Pegomyia hyoscyami), formate via species (Phorbia spp.), Switch Public System species (Stomoxys spp.), Taba Taunus species (Tabanus spp.), Carbon California species (Tannia spp ., Tipula paludosa and Wohlfahrtia spp .

Gas troponin is (Gastropoda) steel, for example, Arion species (Arion spp.), Biom Palazzo Ria species (Biomphalaria spp.), Adversely Taunus species (Bulinus spp.), As having seraseu species (Deroceras spp.), Galvanic species ( Galba spp ., Lymnaea spp ., Oncomelania spp . And Succinea spp .).

Parasitic rivers, such as Ancylostoma duodenale , Ancylostoma ceylanicum , Acylostoma braziliensis , Ancylostoma spp ., Asuka, Ascaris lubricoides , Ascaris spp ., Brugia malayi , Brugia timori , Bunostomum spp ., Chavetia spp ., Aspergillus spp ., Aspergillus spp . For example, Chabertia spp ., Clonorchis spp ., Cooperia spp ., Dicrocoelium spp ., Dictyocaulus filaria , ratum (Diphyllobothrium latum), deuran kunkul loose Medi cis norbornene (Dracunculus medinensis), Versus (Echinococcus granulosus), Kula less (Echinococcus multilocularis) in the multi Kinoko kusu to the Kinoko kusu Gras press, Enterobacter Flavian beomi Kula Li (Enterobius vermicularis), Pacific up species (Faciola spp.), Haemon kusu species (Haemonchus spp.), H. TB kiss species (Heterakis spp.), Hime norep cis Nana (Hymenolepis nana), Rio Strong oyster loose species (Hyostrongulus spp , Loa Loa , Nematodirus spp. , Oesophagostomum spp ., Opisthorchis spp ., Onchocerca volvulus, ), Ostertagia spp ., Paragonimus spp ., Schistosomen spp ., Strongyloides fuelleborni , Strongyloides sterler coral Strongyloides spp ., Strongyloides stercoralis , Stronyloides spp ., Taenia saginata , Taenia solium , Trichinella spiralis , Trichinella sp . other (Trichinella nativa), tree kinel Bree Toby (Trichinella britovi), tree key Nella Ner Sony (Trichinella nelsoni), tree key Nella syudop City Central lease (Trichinella pseudopsiralis), tree courses Tron oysters Ruth species (Trichostrongulus spp.), Tree-ku lease Tree Mystery Ah (Trichuris trichuria ) And Wuchereria bancrofti .

It is also possible to salvage protozoans, for example Eimeria .

For example, Heteroptera spp ., Such as Anasa tristis , Antestiopsis spp ., Blissus spp ., Calocoris spp ., Camphil lomar livi, For example, Campylomma livida , Cavelerius spp. , Cimex spp ., Creontiades dilutus , Dasynus piperis , Dichelops furcatus, ), Diconocoris hewetti , Dysdercus spp ., Euschistus spp ., Eurygaster spp ., Heliopeltis spp. ), Hoshi Asda Nobile Marla Ruth (Horcias nobilellus), repto Cory four kinds (Leptocorisa spp.), as repto article Seuss Philo crispus (Leptoglossus phyllopus), Lee goose species (Lygus spp.), mark Lopez X Cava tooth (Macropes excavatus), (Miridae in the preview), four species grow (Nezara spp.), five To Ruth species (Oebalus spp.), Pen Tommy is on (Pentomidae), PS Do Quad Rata (Piesma quadrata), the piezo doruseu species (Piezodorus spp.), Print salruseu Serie tooth (Psallus seriatus), pseudo-again star flops Seah ( Such as Pseudacysta persea , Rhodnius spp ., Sahlbergella singularis , Scotinophora spp ., Stephanitis nashi , Tibraca spp . Triatoma spp .

Cicadas (Homoptera) Thursday, for example, arc Margarito chiffon species (Acyrthosipon spp.), Four up ah Mia species (Aeneolamia spp.), Diego North Senna species (Agonoscena spp.), Alessio right Death species (Aleurodes spp.) , Aleurolobus barodensis , Aleurothrixus spp ., Amrasca spp ., Anuraphis cardui , Aonidiella spp. Aphis spp ., Arboridia apicalis , Aspidiella spp ., Aspidiotus spp ., Aphis spp ., Aphis spp ., Aphis spp . Atanus spp ., Aulacorthum solani , Bemisia spp ., Brachycaudus helichrysii , Brachycolus spp ., Brevicola spp . Brevicoryne brassicae , Calypso pneumoniae Calligypona marginata , Carneocephala fulgida , Ceratovacuna lanigera , Cercopidae , Ceroplastes spp ., Chaetoshi von Praga, ( Chrysophyceae ), Chrysophyceae , Chrysophyceae, Chrysophyceae , Chrysophyceae, Chrysophyceae , Chrysophyceae, Chrysophyceae , Chrysophyceae, Chrysophyceae , Chaetosiphon fragaefolii , Chionaspis tegalensis , Chlorita tenkii , Chromaphis juglandicola , Chrysomphalus ficus , Cocadulina mbila , Coccomytilus halli , Coccus spp ., Cryptomyzus ribis , Dalbulus spp. , Diaphorina spp ., Diaspis spp ., Doralis spp ., Drosicha spp ., Drosophila spp ., Drosophila spp . Dysaphis spp ., Dysmicoccus spp ., Empoasca spp ., Eriosoma spp ., Erythroneura spp. , Eucelus spp . Such as, for example, Euscelis bilobatus , Geococcus coffeae , Homalodisca coagulata , Hyalopterus arundinis , Icerya spp, Idiocerus spp ., Idioscopus spp ., Laodelphax striatellus , Lecanium spp ., Lepidopsis spp ., Lepidoptera spp ., Lepidoptera spp . Lepidosaphes spp ., Lipaphis erysimi , Macrosiphum spp ., Machanavapim But are not limited to , for example, Mahanarva fimbriolata , Melanaphis sacchari , Metcalfiella spp ., Metopolophium dirhodum , Monellia costalis , But are not limited to, Monelliopsis pecanis , Myzus spp ., Nasonovia ribisnigri , Nephotettix spp ., Nilaparvata lugens , Oncometopia spp ., Orthezia praelonga , Parabemisia myricae , Paratrioza spp ., Parlatoria spp ., Pemphigus spp . Such as Pemphigus spp ., Peregrinus maidis , Phenacoccus spp ., Phloeomyzus passerinii , Phorodon humuli , Species ( Phylloxera spp .), Pina Pinnaspis aspidistrae , Planococcus spp. ), Protopulvinaria pyriformis , Pseudaulacaspis pentagona , Pseudococcus spp. , Psylla spp ., Pteromalus spp . spp.), P GW species (Pyrilla spp.), Quadra speedy ohtuseu species (Quadraspidiotus spp.), Quebec buy exhaust gas (Quesada gigas), last Lokomotiv kusu species (Rastrococcus spp.), with arms sipum species (Rhopalosiphum spp. ), Saissetia spp ., Scaphoides titanus , Schizaphis graminum , Selenaspidus articulatus , Sogata spp ., And the like. ), Sogatella furcifera , Sogatodes spp ., Stictocephala festina , Tenalaphara malayensis , Tinoca saccharia epialae ( Tinocallis caryaefoliae ), Toma 'S piece species (Tomaspis spp.), Flick soap TB species (Toxoptera spp.), Tree Valley right des bar Fora Rio Ram (Trialeurodes vaporarioram), trio character species (Trioza spp.), Tea flow Ciba species (Typhlocyba spp.) , Unaspis spp ., And Viteus vitifolii .

Hymenopera sp ., For example Diprion spp ., Hoplocampa spp ., Lasius spp ., Monomorium pharaonis and Vespa spp . Vespa spp. ).

Isopoda , for example, Armadillidium vulgare , Oniscus asellus and Porcellio scaber .

Isoptera spp ., For example, Reticulitermes spp . And Odontotermes spp .

Lepidoptera species such as, for example, Acronicta major , Aedia leucomelas , Agrotis spp ., Alabama argillacea , Such as Anticarsia spp ., Barathra brassicae , Bucculatrix thurberiella , Bupalus piniarius , Cacoecia podana , Capua reticulana , ( Capua reticulana ), Carpocapsa pomonella , Cheimatobia brumata , Chilo spp ., Choristoneura fumiferana , Clysia ambiguella , Cnaphalocerus spp ., Earias insulana , Ephestia kuehniella , Euproctis chrysorrhoe, a), six children species (Euxoa spp.), pel thiazol species (Feltia spp.), Galleria Mello Nella (Galleria mellonella), helicase Kobe fail-fast species (Helicoverpa spp.), Heliothis species (Heiiothis spp.), Hoffman For example, Hofmannophila Pseudospretella , Homona magnanima , Hyponomeuta padella , Laphygma spp ., Lithocolletis blancardella , Lactobacillus spp . Lithophane antennata , Loxagrotis albicosta , Lymantria spp ., Malacosoma neustria , Mamestra brassicae , Mosesis spp ., Lactobacillus spp . Mocis repanda , Mythirnna separata , Oria spp ., Oulema oryzae , Panolis fla mmea, Pectinopora , Pectinophora gossypie lla ), Phyllocnistis citrella , Pieris spp ., Plutella xylostella , Prodenia spp ., Pseudaletia spp ., Pseudomonas spp . Pseudoplusia includens , Pyrausta nubilalis , Spodoptera spp ., Thermesia gemmatalis , Tinea pellionella , Pseudomonas spp . Tineola bisselliella , Tortrix viridana , and Trichoplusia spp .).

For example, the order Orthoptera , for example Acheta domesticus , Blatta orientalis , Blatella germanica , Gryllotalpa spp. Leucophaea maderae , Locusta spp. , Melanoplus spp., Periplaneta americana , and Schisto-cerca spp. gregaria ).

Siphonaptera , for example, Ceratophyllus spp . And Xenopsylla cheopis .

A neck of Symphyla , for example Scutigerella i mmaculata .

Thrips (Thysanoptera) tree, for example, Bally Haute Lips non formate miss (Baliothrips biformis), the neo-trip spline Bence (Enneothrips flavens), Franc Cleveland you Ella species (Frakliniella spp.), Heliothis TRIPS species (Heliothrips spp , Hercinothrips femoralis , Kakothrips spp ., Rhipiphorothrips cruentatus , Scirtothrips spp ., And the like. Taeniothrips cardamoni and Thrips spp .

Thysanura neck, for example Lepisma saccharina .

Plant propagation nematodes include, for example, Anguina spp ., Aphelenchoides spp ., Belonoaimus spp ., Bursaphelenchus spp . For example, Ditylenchus dipsaci , Globodera spp ., Heliocotylenchus spp ., Heterodera spp ., Longidorus spp ., Melo spp . Such as Meloidogyne spp ., Pratylenchus spp ., Radopholus similis , Rotylenchus spp. , Trichodorus spp ., Tylenol , Colin kusu species (Tylenchorhynchus spp.), butyl renkul loose species (Tylenchulus spp.), butyl renkul loose semi-phenethyl are trans it includes (Tylenchulus semipenetrans) and greater than As nematic species (Xiphinema spp.).

The combination of the active compounds according to the invention is suitable for the treatment of animal parasites (in vitro parasites and body parasites) in the field of veterinary medicine, as well as plant insects, hygiene insects and storage product insects, for example, mites, mites, , Fly (biting and licking), parasitic fly larvae, dandruff, feathers and fleas. These parasites include the following:

The (Anoplurida) tree, for example, Mato blood Taunus species under (Haematopinus spp.), Reno By the tooth species (Linognathus spp.), Phedi cool loose species (Pediculus spp.), Petit loose species (Pthirus spp.) And Soleil Solenopotes spp .

For example, Mallophagida neck and Amblycerina and Ischnocerina subsp ., Such as Trimenopon spp ., Menopon spp ., Trinoton spp . ), Bovicola spp ., Werneckiella spp ., Lepikentron spp ., Damalina spp ., Trichodectes spp . Felicola spp .

Diptera and Nematocerina and Brachycerina subspecies such as Aedes spp ., Anopheles spp ., Culex spp . (For example, Simulium spp ., Eusimulium spp ., Phlebotomus spp ., Lutzomyia spp ., Culicoides spp . Crysops spp ., Hybomitra spp ., Atylotus spp ., Tabanus spp ., Haematopota spp ., Filipomia spp . Such as Staphylococcus spp. , Philipomyia spp. , Braula spp ., Musca spp ., Hydrotaea spp ., Stomoxys spp ., Haematobia spp . , Morelia species (Morellia spp.), plates Chania species (Fannia spp.), Gloucestershire Sinai species (Glossina spp.), Carly Fora species (Calliphora spp.), rusilriah species (Luci Lia spp ., Chrysomyia spp ., Wohlfahrtia spp. , Sarcophaga spp ., Oestrus spp ., Hypoderma spp . , Gasterophilus spp ., Hyppobosca spp ., Lipoptena spp . And Melophagus spp .).

Siphonapterida sp ., For example Pulex spp ., Ctenocephalides spp ., Xenopsylla spp . And Ceratophyllus spp .).

Heteropterida spp ., For example, Cimex spp ., Triatoma spp ., Rhodnius spp . And Panstrongylus spp .).

Blattarida species, for example Blatta orientalis , Periplaneta americana , Blatta germanica , and Supella spp .

Mites (Acaria (Acarida)) subclass and meta- and meso stigmasterol other - (. Ornithodorus spp) (Meta and Mesostigmata) tree, for example, are the gas species (. Argas spp), ornithine Todo loose species, auto Flavian species (Otobius spp.), ikso death species (Ixodes spp.), cancer Bulletin Mama species (Amblyomma spp.), bupil Ruth species (Boophilus spp.), der Do centaur species (Dermancentor spp.), under the village killed lease kinds (Haemaphysalis spp , Hyalomma spp ., Rhipicephalus spp ., Dermanyssus spp ., Raillietia spp ., Pneumonyssus spp ., Pseudomonas spp . ), Sternostoma spp . And Varroa spp .

Actinidia ( Prostigmata ) and Acaridida ( Astigmata ), such as Acarapis spp ., Cheyletiella spp ., And the like. ), Ornithocheyletia spp ., Myobia spp ., Psorergates spp ., Demodex spp ., Trombicula spp . , Listosporus spp ., Acarus spp ., Tyrophagus spp ., Caloglyphus spp ., Hypodectes spp ., And the like. Pterolichus spp. , Psoroptes spp. , Chorioptes spp ., Otodectes spp ., Sarcoptes spp ., Pseudomonas spp . dress species in Noto (Notoedres spp.), shown immense Cope test species (Knemidocoptes spp.), Citrus di test species (Cytodites spp.) and Minoh off test species (Laminosioptes spp.).

Combinations / compositions of active compounds according to the invention may also be used for the production of agricultural productivity livestock such as cattle, sheep, goats, horses, pigs, donkeys, camels, buffalo, rabbits, chickens, turkeys, ducks, , Such as dogs, cats, bird cages and aquarium fish, and so-called laboratory animals, such as hamsters, guinea pigs, rats and mice. Reduction of these arthropods leads to a reduction in mortality and reduced production (in meat, milk, wool, leather, eggs, honey, etc.), so that the use of a combination of active compounds according to the invention makes it possible to economically and easily manage animals Do.

The formulation / composition of active compounds according to the invention may be formulated in the veterinary field, for example by means of tablets, capsules, beverages, potions, granules, pastes, granules, through feed, intramuscularly in the form of suppositories, Parenterally, by injection, by intranasal administration, for example by dipping or bathing, spraying, pouring-on, pouring-on, For example, in the form of spotting-on, washing, dusting, or in the form of a molded article containing the active compound, for example, a necklace, an ear mark, a tail marker, a leg band, Lt; / RTI > is used in a manner known per se by transdermal application.

For use in livestock, poultry, pets, etc., the combination of active compounds may be formulated as a formulation (e.g., emulsion, emulsion, free flowing composition) containing the active compound in an amount of 1 to 80% Or may be used in the form of a chemical bath.

In addition, it has been found that the combination of active compounds according to the invention exhibits a strong insecticidal action against insects which destroy industrial materials.

The following insects may be mentioned as preferred examples, but are not limited to:

Beetles , such as Hylotrupes bajulus , Chlorophorus pilosis , Anobium punctatum , Xestobium rufovillosum , Rhodophyceae , For example, Ptilinus pecticornis , Dendrobium pertinex , Ernobius mollis , Priobium carpini , Lyctus brunneus , Lyctus africanus , Lyctus planicollis , Lyctus linearis , Lyctus pubescens , Trogoxylon aequale , Mintesurugi , and the like. Minthes rugicollis , Xyleborus spp ., Tryptodendron spec ., Apate monachus , Bostrychus capucins , , Heterobostrychus brunnes , Synoxylon spec ., Dinoderus minutus .

Hymenopteran , for example, Sirex jubencus , Urocerus gigas , Urocerus gigas taignus , Urocerus augur, ).

Termites (Termites), for example, a knife Termez flaviviruses Collins (Kalotermes flavicollis), Cryptococcus Termez brevis (Cryptotermes brevis), heteroaryl Termez indicator coke (Heterotermes indicola), retinal Cooley Termez flaviviruses Fes (Reticulitermes flavipes) , Reticulitermes santonensis , Reticulitermes lucifugus , Mastotermes darwiniensis , Zootermopsis nevadensis , Coffea , and the like. Tortelles formosanus ( Coptotermes formosanus ).

Bristletalis , for example, Lepisma saccharina ,

Industrial materials in the present invention should be understood as meaning non-living materials, for example, preferably plastic, adhesives, glue, paper, cardboard, leather, wood, processed wood products and coating compositions.

The ready-to-use composition may, if desired, contain additional pesticides and, if desired, one or more fungicides.

Possible further additives include the above-mentioned insecticides and fungicides.

The formulations / compositions of active compounds according to the invention may also be used to protect objects which are in contact with seawater or saltwater, for example from marine hulls, screens, nets, structures, marine areas and signal transmission systems.

Surprisingly, the combination / composition of active compound according to the invention can be used alone or in combination with other active compounds as an antifouling agent.

The composition / composition of the active compound during the protection of houses, sanitary and storage goods is also suitable for the rescue of animal pests, especially insects, arachnids and mites, appearing in confined spaces such as houses, factory halls, offices, vehicle cabins and the like. They can be used alone or in combination with other active compounds and adjuvants in household pesticide products to relieve these pests. They are effective against susceptible and resistant species and all developmental stages. These pests include:

Scorpion (Scorpionidea) tree, for example tooth portion oxide Kita Taunus (Buthus occitanus).

For example, Acarina neck, such as Argas persicus , Argas reflexus , Bryobia ssp ., Dermanyssus gallinae , For example, Glyciphagus domestigus , Ornithodorus moubat , Rhipicephalus sanguineus , Trombicula alfreddugesi , Neutrombicula ( Neutrombiculae) Autumnalis , Dermatophagoides pteronissimus , Dermatophagoides forinae .

Araneae necks, for example, Aviculariidae , Araneidae ,

Opiliones of the blind, such as Pseudoscorpiones chelifer , Pseudoscorpiones cheiridium , Opiliones phalangium , and the like.

Isopoda necks, such as Oniscus asellus and Porcellio scaber .

Millipedes (Diplopoda) tree, for example Blast niul loose obtain Tula tooth (Blaniulus guttulatus), poly des mousse species (Polydesmus spp.).

Chilopoda neck, for example Geophilus spp .

Zygentoma necks, for example, Ctenolepisma spp. , Lepisma saccharina , Lepismodes inquilinus .

Blattaria necks, such as Blatta orientalis , Blattella germanica , Blattella asahinai , Leucophaea maderae , But are not limited to, Panchlora spp. , Parcoblatta spp ., Periplaneta australasiae , Periplaneta americana , Periplaneta brunnea , Periplaneta fuliginosa , Supella longipalpa .

A species of Saltatoria , for example Acetta domesticus .

Dermaptera neck, for example Forficula auricularia .

Isoptera species, for example, Kalotermes spp. , Reticulitermes spp .

Psocoptera sp. , For example Lepinatus spp. , Liposcelis spp .

Beetles (Coleoptera) Thursday, for example, in the eyes Trail Taunus species (Anthrenus spp.), Oh ridden pandanus species (Attagenus spp.), No scalpel test species (Dermestes spp.), Latte, tea Couscous Duck Party (Latheticus oryzae) , Necrobia spp. , Ptinus spp ., Rhizopertha dominica , Sitophilus granarius , Sitophilus oryzae , Cytophilus oryzae , Sitophilus zeamais , Stegobium paniceum .

Flies (Diptera) tree, for example gipti ah Rhodes O (Aedes aegypti), O Death al bopik tooth (Aedes albopictus), O Death other Ennis Orin kusu (Aedes taeniorhynchus), anopheles species (Anopheles spp.) In the , Carly Fora erythromycin Seppala (Calliphora erythrocephala), Creative tank or plug Ruby Alice (Chrysozona pluvialis), the Culex kwinku par Shia tooth (Culex quinquefasciatus), Culex Phi Enschede (Culex pipiens), Culex tar buy leases (Culex Tarsalis , Drosophila spp. , Fannia canicularis , Musca domestica , Phlebotomus spp. , Sarcophaga spp. carnaria , Simulium spp ., Stomoxys calcitrans , and Tipula paludosa .

For example, Lepidoptera species such as Achroia grisella , Galleria mellonella , Plodia interpunctella , Tinea cloacella , Tinea pelionella , Tinea pellionella , Tineola bisselliella .

For example, the order Siphonaptera , for example, Ctenocephalides canis , Ctenocephalides felis , Pulex irritans , Tunga penetrans , Keephis ( Xenopsylla cheopis ).

For example, Hymenopera species such as Camponotus herculeanus , Lasius fuliginosus , Lasius niger , Lasius umbratus , Mono < ( R ) > Monomorium pharaonis , Paravespula spp. , Tetramorium caespitum .

Anoplura species such as Pediculus humanus capitis , Pediculus humanus corporis , Pemphigus spp ., Philoelavastatrix ( Pseudomonas spp .), Phylloera vastatrix ), Pthirus pubis .

Heteroptera species such as Cimex hemipterus , Cimex lectularius , Rhodnius prolixus , Triatoma infestans , and the like.

In the field of domestic pesticides, they are applied alone or in combination with other suitable active compounds, for example, active compounds selected from the group of phosphate esters, carbamates, pyrethroids, neonitinoids, growth regulators or other known pesticide groups.

These include, but are not limited to, aerosols, pressureless spray products such as pump and atomizer sprays, automatic injection systems, foggers, foams, gels, evaporation tablets made of cellulose or polymer, liquid evaporators, A propellant-operated evaporator, a non-energy or manual evaporation system, a moth paper, a bag and a mos gel, which are used as granules or powders in a bait or manure area for application.

In addition, the formulations and compositions according to the present invention can be used to reduce fungal toxic content in harvested plant material and food and animal feeds made therefrom.

Particularly, in this case, fungal dock includes, for example, Fusarium acuminatum , F. avenaceum , F. crookwellense , Fusarium spp. F. culmorum , F. graminearum ( Gibberella zeae ), F. equiseti , F. fujikoroi , Fusarium musarum Fungi , F. musarum , F. oxysporum , F. proliferatum , F. poae , F. pseudograminearum , F. sambucinum , F. scirpi , F. semitectum , F. solani , F. sporotrichoides ), F. langsethiae , F. subglutinans , fusarium Fungi such as Fusarium sp . , Such as Ficus spp . , F. tricinctum and F. verticillioides , and especially fungi such as Aspergillus spp., Penicillium spp. (DON), nivalenol, 15-Ac-DON, 3- (4-hydroxyphenyl) -3,5-dihydroquinoline, which are caused by the following species: Penicillium spec ., Claviceps purpurea , Stachybotrys spec . Ac-DON, T2- and HT2-toxin, Fumonisines, Zearalenone, Monilifor-mine, Fusarine, Diaceotoxyscirp-nole ; DAS), Beauvericine, Enniatine, Fusaroproliferi-ne, Fusarenole, Ochratoxines, Patuline, Ergot alkaloids Ergot alkaloid, and Aflatoxines may be mentioned, but are not limited thereto.

The excellent fungicidal effect of the formulations and compositions according to the invention is evidenced by the following examples. While the single active compound has a weak fungicidal effect, the combination or composition exhibits a greater effect than the sum of the effects of each compound.

In fungicides, when calculated according to SR Colby, "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds, 1967, 15, 20-22, A synergistic effect is always present if fungicidal activity is greater than the expected activity for a given combination of two or three active compounds.

The Colby formula is a binary mixture of the following Colby formula:

For a three-way mixture, it can be defined as the following Corby formula:

In this formula,

X is effective when the active compound A is applied in a specified capacity of m ppm,

Y is an effect when the active compound B is applied at a specified dose of n ppm,

Z is an effect when the active compound C is applied in a specified capacity of r ppm,

E ₁ is an effect when the active compounds A and B are applied together at a specified dose of m and n ppm,

E ₂ is an effect when the active compounds A and B and C are applied at the indicated doses of m and n and r ppm, respectively.

At this time, the effect is determined in%. 0% is a comparable effect to the control, and a 100% effect means no infection.

If the actual observed effect is greater than the expected effect calculated using the Corvic equation, the effect of the formulation or composition is superadditive, i.e. there is a synergistic effect.

The following examples illustrate the invention.

Example 1

Pyricularia oryzae Test (rice) / Preventive

Solvent: N, N-dimethylformamide 50 parts by weight

Emulsifier: alkylaryl polyglycol ether 1 part by weight

One part by weight of the active compound is mixed with the above-mentioned amount of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration to prepare a suitable preparation of the active compound.

For prophylactic activity, the young plants were sprayed with the active compound preparation at a specified application rate. After spray coating and drying, the plants were sprayed with a suspension of pyriculorite material. The plants were then placed in a greenhouse at 100% relative atmospheric humidity and 25 < 0 > C.

The test was evaluated 10 days after inoculation. 0% means the effect corresponding to the control group, and 100% means no disease was observed at all.

Table 1

Pyricularia oryzae Test (rice) / Preventive

Example 2

Blumeria test (rice) / 5 days prevention

Solvent: N, N-dimethylformamide 50 parts by weight

Emulsifier: alkylaryl polyglycol ether 1 part by weight

1 part by weight of the active compound or combination of active compounds is mixed with the above-mentioned amounts of the solvent and emulsifier, and the concentrate is diluted with water to the desired concentration to prepare a suitable preparation of the active compound.

For prophylactic activity, the young plant is sprayed with the active compound preparation or a combination of active compounds at a specified application rate.

Five days after application of the spray, the plants were sprayed with blue mera granis f. Hormones ( Blumeria graminis f.sp. hordei ) were sprinkled.

The plants were then placed in a greenhouse at a relative atmospheric humidity of about 80% and a temperature of about 20 < 0 > C to promote the development of white pellet pustule.

The test was evaluated 7 days after inoculation. 0% means the effect corresponding to the control group, and 100% means no disease was observed at all.

Table 2

Blumeria test (rice) / 5 days prevention

≪ / RTI > to yield the effect on the combination of the two compounds.

The expected effect on the combination of the two given compounds is calculated as follows (see Colby, SR, "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations ", Weeds 15, pp. 20-22, 1967]:

In this formula,

X is the effect expressed as the insecticidal rate (%) for the untreated control group when the active compound A is applied at a concentration of m ppm or an application rate of m g / ha, respectively,

Y is the effect expressed as the insecticidal rate (%) for the untreated control when the active compound B is applied at a concentration of n ppm or at an application rate of n g / ha,

Z is the effect expressed as the percent of insecticidal activity (%) for the untreated control when the active compound C is applied at a concentration of o ppm or at an application rate of o g / ha,

E is the effect expressed as the percent insecticidal (%) for the untreated control when the mixture of A, B and C is applied at a concentration of m, n and o ppm or at application rates of m, n and o g / ha.

If the insecticidal effect of the observed combination exceeds a value calculated as "E ", the combination of the two compounds is additive, i.e. there is a synergistic effect.

Example 3

Heliothis armigera test

Solvent: Dimethylformamide 7 parts by weight

Emulsifier: alkylaryl polyglycol ether 2 parts by weight

One part by weight of active compound is mixed with the above-mentioned amount of solvent and emulsifier, and the concentrate is diluted with water containing emulsifier to the desired concentration to prepare a suitable preparation of active compound.

Soybean ( Glycine max ) was sprayed with the active compound formulation at the specified application rate and infected with the Heliothis armigera larvae while the leaves were wet.

After a certain period of time, the mortality rate was determined as%. 100% means that all caterpillars have been salvaged; 0% means that none of the caterpillars have been saved.

According to the present application, in this test, for example, the following formulations showed a synergistic effect over the sole compound:

Table 3

Heliothis armigera test

Example 4

Nilaparvata lugens test

Solvent: Dimethylformamide 7 parts by weight

Emulsifier: alkylaryl polyglycol ether 2 parts by weight

One part by weight of active compound is mixed with the above-mentioned amount of solvent and emulsifier, and the concentrate is diluted with water containing emulsifier to the desired concentration to prepare a suitable preparation of active compound.

The rice plant ( Oryza sativa ) was sprayed with the active compound preparation at the specified application rate and infected with the Nilaparvata lugens larvae while the leaves were wet.

After a certain period of time, the mortality rate was determined as%. 100% means that all the broad-leaved larvae have been rescued; 0% means that none of the broad-leaved larvae were rescued.

According to the present application, in this test, for example, the following formulations showed a synergistic effect over the sole compound:

Table 4

Nilaparvata lugens test

Example 5

Phaedon cochleariae - test

Solvent: Dimethylformamide 7 parts by weight

Emulsifier: alkylaryl polyglycol ether 2 parts by weight

One part by weight of active compound is mixed with the above-mentioned amount of solvent and emulsifier, and the concentrate is diluted with water containing emulsifier to the desired concentration to prepare a suitable preparation of active compound.

Cabbage ( Brassica oleracea ) leaves were treated by spraying with the active compound preparation at the desired concentration and infected with mustard worms ( Phaedon cochleariae ) larvae while the leaves were wet.

After a certain period of time, the mortality rate was determined as%. 100% means all mustard insect larvae have been rescued; 0% means that none of the larvae of mustard bugs have been saved.

According to the present application, in this test, for example, the following formulations showed a synergistic effect over the sole compound:

Table 5-1

Phaedon cochleariae - test

Table 5-2

Phaedon cochleariae - test

Example 6

Spodoptera frugiperda test

Solvent: Dimethylformamide 7 parts by weight

Emulsifier: alkylaryl polyglycol ether 2 parts by weight

One part by weight of active compound is mixed with the above-mentioned amount of solvent and emulsifier, and the concentrate is diluted with water containing emulsifier to the desired concentration to prepare a suitable preparation of active compound.

Cabbage ( Brassica oleracea ) leaves were treated by immersion in the active compound preparation at the desired concentration and infected with Spodoptera frugiperda larvae while the leaves were wet.

After a certain period of time, the mortality rate was determined as%. 100% means that all caterpillars have been salvaged; 0% means that none of the caterpillars have been saved.

According to the present application, in this test, for example, the following formulations showed a synergistic effect over the sole compound:

Table D

Spodoptera frugiperda test

Claims (12)

(A) 3,4-dichloro-N- (2-cyanophenyl) -5-isothiazocarboxamide,
(B) imidacloprid and
(C) spinosad and (S) -3-chloro-N1- {2-methyl-4- [1,2,2,2-tetrafluoro-1- (trifluoromethyl) - (1-methyl-2-methylsulfonylethyl) phthalamide. The combination according to claim 1, wherein the weight ratio between any two components of (A), (B) or (C) is independently from 1: 100 to 100: 1. The combination according to claim 1, further comprising an adjuvant, a solvent, a carrier, a surfactant or an extender. Including the application of the combination according to paragraph 1 to seeds, plant propagation material, plants, fruits of plants or to the soil for which the plant is to be grown or to be cultivated,
Of plants or crops
A method for relieving one or more selected from the group consisting of phytopathogenic fungi, bacterial organisms, protozoan organisms, and insects. The method according to claim 4, comprising applying the compounds (A), (B) and (C) of the combination according to claim 1 either simultaneously or sequentially. The method according to claim 4, wherein the amount of the blend according to claim 1 is from 0.1 g / ha to 10 kg / ha for leaf treatment and soil treatment, and from 2 to 200 g per 100 kg seed for seed treatment. A method for treating seed, comprising applying the combination according to claim 1 to the seed. 8. The method of claim 7, wherein the seed is a transgenic seed. A method for protecting sprouts and leaves of plants grown from seeds and / or seeds from insects or fungi, comprising treating seeds not seeded with the combination according to claim 1. The method according to claim 9, wherein the seeds are treated simultaneously with the compounds (A), (B) and (C) of the combination according to claim 1. 11. The method according to claim 10, wherein the seeds are treated separately with the compounds (A), (B) and (C) of the combination according to claim 1. A seed treated with the combination according to claim 1.